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https://www.readbyqxmd.com/read/29132294/artificial-selection-for-odor-guided-behavior-in-drosophila-reveals-changes-in-food-consumption
#1
Elizabeth B Brown, Cody Patterson, Rayanne Pancoast, Stephanie M Rollmann
BACKGROUND: The olfactory system enables organisms to detect chemical cues in the environment and can signal the availability of food or the presence of a predator. Appropriate behavioral responses to these chemical cues are therefore important for organismal survival and can influence traits such as organismal life span and food consumption. However, understanding the genetic mechanisms underlying odor-guided behavior, correlated responses in other traits, and how these constrain or promote their evolution, remain an important challenge...
November 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28913160/pancoast-tumor-approach-through-oesophagus
#2
Eritjan Tashi, Perlat Kapisyzi, Daniela Xhemalaj, Alma Andoni, Ilir Peposhi
Patient with Pancoast Tumor usually present in advanced stage of the disease which requires chemotherapy and radiotherapy as options of treatment. Histologic confirmation is a key for further treatment of these patients. Normally in bronchoscopy the lesion can't be visualised and in result making biopsy difficult to perform. Transthoracic biopsy through computed tomography poses anatomic difficulties and not always the pulmonary lesion can be reached. We report a case of pancoast tumor in a 68 year old male who presented with left arm pain and upper lobe increased density mass in chest x ray...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28874358/soluble-interleukin-13r%C3%AE-1-a-circulating-regulator-of-glucose
#3
Inbal Rachmin, Caitlin C O'Meara, Elisabeth M Ricci-Blair, Yilin Feng, Emily M Christensen, Jeanne F Duffy, Kirsi M Zitting, Charles A Czeisler, James R Pancoast, Christopher P Cannon, Michelle L O'Donoghue, David A Morrow, Richard T Lee
Soluble IL-13 receptor alpha 1, or sIL13rα1, is a soluble protein that binds to Interleukin 13 (IL-13) and that has been previously described in mice. The function of sIL13rα1 remains unclear, but it has been hypothesized to act as a decoy receptor for IL-13. Recent studies have identified a role for IL-13 in glucose metabolism, suggesting that a decoy receptor for IL-13 might increase circulating glucose levels. Here we report that delivery of sIL13rα1 to mice by either gene transfer or recombinant protein decreases blood glucose levels...
September 5, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28684005/assessment-of-contemporary-aggressive-surgical-resection-for-superior-sulcus-and-pancoast-lung-tumors
#4
EDITORIAL
P Michael McFadden, Luke M Wiggins
No abstract text is available yet for this article.
2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28684003/surgical-treatment-of-superior-sulcus-tumors-a-15-year-single-center-experience
#5
Piergiorgio Solli, Monica Casiraghi, Daniela Brambilla, Patrick Maisonneuve, Lorenzo Spaggiari
This paper reports on the characteristics, treatment modalities, and outcomes of patients with superior sulcus tumors who underwent surgery over a period of 15 years in 1 institution. Clinical records of 94 consecutive patients operated on by the same surgical team for non-small cell lung cancer between July 1998 and December 2013 were retrospectively reviewed. All patients received lung and chest wall en bloc resection. Forty-eight (51%) received induction treatments. Surgery was an anterior approach in 46 patients (48...
April 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28648878/an-effective-and-safe-surgical-approach-for-a-superior-sulcus-tumor-a-case-report
#6
Soichi Oka, Kenichi Kobayashi, Hiroki Matsumiya, Masatoshi Kanayama, Shuichi Shinohara, Shinji Shinohara, Akihiro Taira, Taiji Kuwata, Masaru Takenaka, Yasuhiro Chikaishi, Ayako Hirai, Yuko Tashima, Naoko Imanishi, Koji Kuroda, Yoshinobu Ichiki, Fumihiro Tanaka
INTRODUCTION: Superior sulcus tumors, frequently referred to as Pancoast tumors, are a wide range of tumors invading a section of the apical chest wall called the thoracic inlet. For this reason, a surgical approach and complete resection may be difficult to accomplish. We experienced a locally advanced superior sulcus tumor (SST) located from the anterior to posterior apex thoracic inlet and performed complete resection after definitive chemoradiation. PRESENTATION OF CASE: A 71-year-old Japanese male presented at our hospital due to left back pain and an abnormal chest computed tomography (CT) scan showing 80×70×60-mm tumor located in the left middle apex thoracic inlet...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28596442/an-unusual-but-classic-cause-of-hand-numbness-pancoast-tumour
#7
Elena Thampy, Sujith V Cherian
No abstract text is available yet for this article.
June 8, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28484150/less-invasive-approach-to-pancoast-tumor-in-a-partitioned-incision
#8
Norikazu Kawai, Takeshi Kawaguchi, Motoaki Yasukawa, Takashi Watanabe, Takashi Tojo
We describe our approach to resect a Pancoast tumor with thoracoscopic assistance in a partitioned incision. We used the LigaSure vessel-sealing system under thoracoscopy in chest wall resection for Pancoast tumor. This approach is of great utility: easy-to use and less invasive for Pancoast tumor resection.
June 20, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28407246/trimodality-therapy-for-pancoast-tumors-t4-is-not-a-contraindication-to-radical-surgery
#9
Ryuichi Waseda, Thomas Klikovits, Mir Alireza Hoda, Konrad Hoetzenecker, Pietro Bertoglio, Karin Dieckmann, Sabine Zöchbauer-Müller, Robert Pirker, Helmut Prosch, Balazs Döme, Walter Klepetko
OBJECTIVE: This study aims to evaluate the impact of T stage and extended surgery on the outcome of patients with Pancoast tumors after induction chemoradiation therapy. METHODS: Forty-six consecutive patients who underwent chemoradiation therapy (platin-based, 45-66 Gy) followed by surgery between 1998 and 2013 were retrospectively reviewed and analyzed. RESULTS: In 28 (61%) patients with T4 tumors, extended procedures (more than rib resection) were performed...
August 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28363369/management-of-lung-cancer-invading-the-superior-sulcus
#10
REVIEW
Johannes R Kratz, Gavitt Woodard, David M Jablons
Superior sulcus tumors have posed a formidable therapeutic challenge since their original description by Pancoast and Tobias in the early twentieth century. Initial therapeutic efforts with radiotherapy were associated with high rates of relapse and mortality. Bimodality therapy with complete surgical resection in the 1960s paved the way for trimodality therapy as the current standard of care in the treatment of superior sulcus tumors. The evolution of treatment approaches over time has provided outcomes that come increasingly closer to rivaling those of similarly staged nonapical lung cancer...
May 2017: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/28343156/ectopic-acth-producing-large-cell-neuroendocrine-pancoast-tumour-presenting-as-horner-syndrome
#11
Rajanshu Verma, Alexandra Lambert, Harold H Katz, Scott J Benson
We present an interesting case where a patient is presented with a droopy left eyelid (as part of Horner syndrome) and Cushingoid features which were a result of a Pancoast tumour (apical lung tumour in superior pulmonary sulcus) involving the left lung. This tumour was secreting ectopic adrenocorticotropic hormone (ACTH), a paraneoplastic endocrine phenomenon, which resulted in Cushing syndrome symptomatology. Though most ectopic ACTH-producing lung cancers are either small cell or carcinoid tumours, this was in fact a large cell neuroendocrine cancer (LCNEC)...
March 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28264709/a-rare-presentation-of-myxofibrosarcoma-as-a-pancoast-tumor-a-case-report
#12
Vasa Jevremovic, Adnan Yousuf, Zulfiqar Hussain, Amer Abboud, Edgar G Chedrawy
BACKGROUND: Myxofibrosarcoma is an aggressive soft tissue neoplasm, classified as a variant of malignant fibrous histiocytoma. Most often, it occurs in middle to late adult life peaking in the seventh decade and involving the lower extremities (77%), trunk (12%), and retroperitoneum or mediastinum (8%). We report the first case of thoracic myxofibrosarcoma presenting as a Pancoast tumor. CASE PRESENTATION: A 48-year-old non-tobacco smoking African-American man presented with a slow-growing mass in his neck along with 11 kg weight loss over 9 months...
March 7, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27994780/single-posterior-approach-for-en-bloc-resection-and-stabilization-for-locally-advanced-pancoast-tumors-involving-the-spine-single-centre-experience
#13
Fahed Zairi, Tarek Sunna, Moishe Liberman, Ghassan Boubez, Zhi Wang, Daniel Shedid
STUDY DESIGN: Monocentric prospective study. PURPOSE: To assess the safety and effectiveness of the posterior approach for resection of advanced Pancoast tumors. OVERVIEW OF LITERATURE: In patients with advanced Pancoast tumors invading the spine, most surgical teams consider the combined approach to be necessary for "en-bloc" resection to control visceral, vascular, and neurological structures. We report our preliminary experience with a single-stage posterior approach...
December 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27786592/diagnosing-and-treating-pancoast-tumors
#14
REVIEW
Konstantinos Zarogoulidis, Konstantinos Porpodis, Kelly Domvri, Ellada Eleftheriadou, Despoina Ioannidou, Paul Zarogoulidis
According to the American College of Chest Physician definition, a Pancoast tumor is a tumor which invades any of the structures of the apex of the chest including the first thoracic ribs or periosteum, the lower nerve roots of the bronchial plexus, the sympathetic chain and stellate gaglion near the apex of the chest or the subclavian vessels. Pancoast tumors account for less than 3-5 % of lung tumors. Areas covered: We searched the libraries scopus and pub med and found 124 related manuscripts. From those we chose 18 to include in our short commentary based on the most up-date information included...
December 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27595391/-malignant-rhabdoid-tumor-of-the-lung
#15
M Zysman, C Clement-Duchene, C Bastien, P Vaillant, Y Martinet
INTRODUCTION: Rhabdoid tumours usually develop in brain and spinal cord or kidney; they are highly malignant neoplasms that typically arise in infancy and early childhood. However, rare cases of pulmonary localization have been described, particularly among young adults. CASE REPORT: A 26-year-old man, smoker, had a right apical lung mass associated with a Pancoast syndrome leading to haemoptysis. There was also a tumour of the left thigh and scalp. Histological samples taken at these three locations were in favour of an undifferentiated carcinoma...
November 2016: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/27594957/an-unusual-cause-of-acute-headache-subarachnoid-free-air-secondary-to-spontaneous-bronchopleurodurosubarachnoid-fistula-from-a-pancoast-tumor
#16
Dmitriy N Kazimirko, Ellen E Parker, David A Joyner, Teddi H Berry, Charlotte S Taylor, Todd A Nichols, Majid A Khan
Pneumocephalus and pneumorrhachis are related to transgression of the barriers to the central nervous system. We present a patient with a Pancoast tumor treated with palliative chemoradiation who developed symptomatic spinal and intracranial air caused by spontaneous bronchopleurodurosubarachnoid fistula secondary to direct tumor invasion into the thecal sac.
September 2016: Radiology case reports
https://www.readbyqxmd.com/read/27556670/resection-of-the-first-rib-with-preservation-of-the-t1-nerve-root-in-pancoast-tumors-of-the-lung
#17
Andreas K Filis, Lary A Robinson, Frank D Vrionis
BACKGROUND: Surgical outcomes for Pancoast (superior sulcus) tumors of the lung have significantly changed during the last few decades and have improved with use of curative-intent surgery by utilizing en bloc complete resections. METHODS: A retrospective analysis was conducted of 11 selected patients treated at Moffitt Cancer Center from 2007 to 2016. Data from patient records were collected and analyzed. RESULTS: All 11 patients with a Pancoast tumor involving the first rib had their T1 root preserved at surgery...
July 2016: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/27504558/spindle-cell-sarcoma-presenting-as-pancoast-syndrome
#18
Aliena Badshah, Salman Khan, Usman Saeed
This report describes a patient who presented with pancoast syndrome, secondary to spindle cell sarcoma of the lung. A 56-year man presented with dyspnea, engorged neck veins and bilateral upper limb pitting edema. The patient also had ptosis and miosis in the right eye. Right ulnar nerve palsy with atrophy of hand muscles was seen. His chest X-ray showed bilateral pleural effusion with an opacity involving the apex of the right lung along with mediastinal widening. Echocardiography revealed a pericardial effusion which was drained...
July 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27477204/the-pennsylvania-anatomy-act-of-1883-weighing-the-roles-of-professor-william-smith-forbes-and-senator-william-james-mcknight
#19
James R Wright
Effective Anatomical Acts transformed medical education and curtailed grave-robbing. William S. Forbes, Demonstrator of Anatomy at Jefferson Medical College in Philadelphia, authored the Pennsylvania Anatomy Act of 1867, but it was ineffective. In December of 1882, Forbes and accomplices were charged with grave-robbing. Forbes was acquitted in early 1883, but his accomplices were all convicted; nevertheless, these events precipitated a strengthened Anatomy Act in 1883. Forbes was crowned the Father of the Pennsylvania Anatomy Act and was revered by the Philadelphia medical community for his personal sacrifices for medical education; they even paid his legal fees...
October 2016: Journal of the History of Medicine and Allied Sciences
https://www.readbyqxmd.com/read/27453409/the-presentation-of-plastic-surgery-visual-data-from-1816-to-1916-the-evolution-of-reproducible-results
#20
REVIEW
M Felix Freshwater
All scientific data should be presented with sufficient accuracy and precision so that they can be both analyzed properly and reproduced. Visual data are the foundation upon which plastic surgeons advance knowledge. We use visual data to achieve reproducible results by discerning details of procedures and differences between pre- and post-surgery images. This review highlights how the presentation of visual data evolved from 1816, when Joseph Carpue published his book on nasal reconstruction to 1916, when Captain Harold Gillies began to treat over 2000 casualties from the Battle of the Somme...
September 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
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