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https://www.readbyqxmd.com/read/28077319/role-of-insulin-like-growth-factor-axis-in-the-bleomycin-induced-lung-injury-in-rats
#1
Lakshmi Kanth Kotarkonda, Ritu Kulshrestha, Krishnan Ravi
BACKGROUND: Alveolar epithelial cell injury has been proposed as a causative factor for the onset and progression of pulmonary fibrosis. However, the role of type II alveolar epithelial cells (AECs) in the epithelial mesenchymal transition (EMT) is controversial. AIMS: The present study performed in rats instilled with bleomycin investigated a) the expressions of the insulin growth factor (IGF-1) and insulin growth factor binding protein 5 (IGFBP-5) and transforming growth factor (TGF-β1) in the type II AECs, b) the role of type II AECs in EMT and extracellular matrix (ECM) formation and, c) the effect of pioglitazone on all the above parameters...
January 7, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28071888/synthesis-and-supercapacitor-application-of-alkynyl-carbon-materials-derived-from-cac2-and-polyhalogenated-hydrocarbons-by-interfacial-mechanochemical-reactions
#2
Yingjie Li, Qingnan Liu, Wenfeng Li, Hong Meng, Yingzhou Lu, Chunxi Li
The discovery of new carbon materials and the reactive activation of CaC2 are challenging subjects. In this study, a series of alkynyl carbon materials (ACMs) were synthesized by the interfacial mechanochemical reaction of CaC2 with four typical polyhalogenated hydrocarbons. Their properties and structures were characterized, and their electrochemical performances were examined. The reaction was rapid and efficient arising from the intense mechanical activation of CaC2. The ACMs are micro-mesoporous materials with distinct layered structure, specific graphitization degree, and clear existence of sp-C...
January 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28070109/apoptosis-and-surfactant-protein-c-expression-inhibition-induced-by-lipopolysaccharide-in-aec-ii-cell-may-associate-with-nf-%C3%AE%C2%BAb-pathway
#3
Jinle Lin, Jun Tian, Li Wang, Weigang Wu, Huaying Li, Xueyan Wang, Xiaobin Zeng, Wenwu Zhang
Lipopolysaccharide (LPS), a Gram-negative bacterial outer membrane component, is one of the major causes of septic shock. Herein we investigate LPS-induced apoptosis of rat alveolar epithelial type II cells (AEC II) and the effects of LPS on surfactant protein-C (SP-C) expression in AEC II, along with the possible molecular mechanisms. LPS exposure impaired cell viability and increased apoptosis of AEC II significantly in concentration-dependent manner embodied in increased caspase-3 expression and the activity of caspase-3...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28062213/anti-fibrotic-effects-of-bone-morphogenetic-protein-7-modified-bone-marrow-mesenchymal-stem-cells-on-silica-induced-pulmonary-fibrosis
#4
Xiaoli Li, Guoliang An, Yan Wang, Di Liang, Zhonghui Zhu, Ximeng Lian, Piye Niu, Caixia Guo, Lin Tian
Silicosis is an occupational lung disease caused by exposure to small particles of crystalline silica, which ultimately results in diffuse pulmonary fibrosis. Evidence indicates an anti-fibrotic role of bone morphogenetic protein-7 (BMP-7) and bone marrow mesenchymal stem cells (BMSCs) in lung diseases. Therefore, strategies incorporating genetic engineering and stem cell biology might have a tremendous potential to treat critical injuries and diseases. Therefore, we modified BMSCs to overexpress the BMP-7 gene (BMP-7-BMSCs) by lentivirus transduction, and then evaluated whether fibrotic processes were inhibited by these cells in vivo...
January 4, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28042067/a-cross-sectional-study-on-the-symptom-burden-of-patients-with-spinal-tumor-validation-of-the-chinese-version-of-the-md-anderson-symptom-inventory-spine-tumor-module-mdasi-sp
#5
Nanfang Xu, Zhehuang Li, Xiaoguang Liu, Liang Jiang, Na Meng, Ping Jiang, Miao Yu, Fengliang Wu, Lei Dang, Hua Zhou, Yan Li, Feng Wei, Zhongjun Liu
CONTEXT: Tumors involving the spine are associated with unique symptoms affecting both patient survival and health-related quality of life (HRQoL). Currently, there is no disease-specific instrument in Chinese to assess the symptom burden of these patients. OBJECTIVES: To translate and validate a Chinese version of the MD Anderson Symptom Inventory - Spine Tumor Module (MDASI-SP-C) in order to assess the symptom burden of Chinese-speaking patients with spinal tumors...
December 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27988781/five-new-species-of-the-i-clubiona-i-i-corticalis-i-species-group-araneae-clubionidae-from-china
#6
Ping Liu, Xianjin Peng, Hengmei Yan
Five new species of the genus Clubiona collected in Mt. Gaoligong, Yunnan Province, China are described: C. biforamina n. sp., C. dactylina n. sp., C. falciforma n. sp., C. multidentata n. sp. and C. tangi n. sp., all belonging to the corticalis species group and known from both males and females.
November 7, 2016: Zootaxa
https://www.readbyqxmd.com/read/27973472/in-vitro-and-in-vivo-comparison-between-poractant-alfa-and-the-new-generation-synthetic-surfactant-chf5633
#7
Francesca Ricci, Xabier Murgia, Roberta Razzetti, Nicola Pelizzi, Fabrizio Salomone
BACKGROUND: CHF5633 is a new generation synthetic surfactant containing both SP-B and SP-C analogues developed for the treatment of respiratory distress syndrome. Here, the optimal dose and its performance in comparison to the animal-derived surfactant poractant alfa were investigated. METHODS: In vitro surfactant activity was determined by means of the Wilhelmy balance and the capillary surfactometer. The dose-finding study was performed in preterm rabbits with severe surfactant deficiency...
December 14, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27967234/alternative-progenitor-lineages-regenerate-the-adult-lung-depleted-of-type-ii-cells
#8
Min Yee, William Domm, Robert Gelein, Karen L de Mesy Bentley, R Matthew Kottmann, Patricia J Sime, B Paige Lawrence, Michael A O'Reilly
An aberrant oxygen environment at birth increases the severity of respiratory viral infections later in life through poorly understood mechanisms. Here we show that alveolar epithelial type II (AEC2) cells, a progenitor for AEC1 cells are depleted in adult mice exposed to neonatal hypoxia or hyperoxia. Airway cells expressing SP-C and ABCA3, alveolar pod cells expressing KRT5, and pulmonary fibrosis was observed when these mice were infected with a sublethal dose of HKx31, H3N2 influenza A virus (IAV). This was not seen in infected siblings birthed into room air...
December 14, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27951703/modeling-the-hydrophobicity-of-nanoparticles-and-their-interaction-with-lipids-and-proteins
#9
Ali Ramazani, Taraknath Mandal, Ronald G Larson
We present a method of modeling nanoparticle (NP) hydrophobicity using coarse-grained molecular dynamics (CG MD) simulations, and apply this to the interaction of lipids with nanoparticles. To model at a coarse-grained level the wettability or hydrophobicity of a given material, we choose the MARTINI coarse-grained force field, and determine through simulation the contact angles of MARTINI water droplets residing on flat regular surfaces composed of various MARTINI bead types (C1, C2, etc.). Each surface is composed of a single bead type in each of three crystallographic symmetries (FCC, BCC, and HCP)...
December 13, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27886969/a-pilot-study-to-gauge-effectiveness-of-standardized-patient-scenarios-in-assessing-general-surgery-milestones
#10
REVIEW
Denise W Gee, Roy Phitayakorn, Avni Khatri, Kathryn Butler, John T Mullen, Emil R Petrusa
PURPOSE: Some General Surgery Milestones can be difficult to assess in traditional clinical settings and especially difficult to assess in junior residents. The purpose of this pilot study was to METHODS: A total of 9 categorical interns participated in a comprehensive, 4-module, SP scenario designed to evaluate and manage right upper quadrant pain. SP checklist scores (SP%) were converted to Milestone-equivalent scores for direct comparison (SP-C). Milestone scores were analyzed from 3 different sources: SP, faculty (FAC), and CCC...
November 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27884070/association-of-sp-c-gene-codon-186-polymorphism-rs1124-and-risk-of-rds
#11
Neda Fatahi, Hosein Dalili, Majid Kalani, Nikoo Niknafs, Mamak Shariat, Javad Tavakkoly-Bazzaz, Elaheh Amini, Tahereh Esmaeilnia Shirvani, Amir Kamal Hardani, Roya Taheritafti, Nasrin Ghasemi-Fakhr, Mohsen Ghadami, Fatemeh Nayeri, Ali Rashidi-Nezhad
BACKGROUND: Respiratory distress syndrome (RDS) is a severe pulmonary disease that mainly affects preterm neonates. Surfactant-protein genes' polymorphisms have been mostly evaluated as the candidate contributors in genetics of RDS. However, the results are diverse in different populations. We aimed at investigating the association of rs1124 with RDS development. METHOD: Three hundred and thirty five preterm neonates were enrolled in a multicenter case-control study...
November 24, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27868423/startle-potentiation-to-uncertain-threat-as-a-psychophysiological-indicator-of-fear-based-psychopathology-an-examination-across-multiple-internalizing-disorders
#12
Stephanie M Gorka, Lynne Lieberman, Stewart A Shankman, K Luan Phan
Heightened reactivity to uncertain threat (U-threat) is an important individual difference factor that may characterize fear-based internalizing psychopathologies (IPs) and distinguish them from distress/misery IPs. To date, however, the majority of existing research examining reactivity to U-threat has been within individuals with panic disorder and major depressive disorder (MDD) and no prior study has directly tested this hypothesis across multiple IPs. The current study therefore explored whether heightened reactivity to U-threat is a psychophysiological indicator of fear-based psychopathology across 5 groups: current (a) social anxiety disorder (SAD); (b) specific phobia (SP); (c) generalized anxiety disorder (GAD); (d) MDD; and (c) individuals with no history of psychopathology (controls)...
January 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27812430/synthetic-lung-surfactants-containing-sp-b-and-sp-c-peptides-plus-novel-phospholipase-resistant-lipids-or-glycerophospholipids
#13
Robert H Notter, Rohun Gupta, Adrian L Schwan, Zhengdong Wang, Mohanad Gh Shkoor, Frans J Walther
BACKGROUND: This study examines the biophysical and preclinical pulmonary activity of synthetic lung surfactants containing novel phospholipase-resistant phosphonolipids or synthetic glycerophospholipids combined with Super Mini-B (S-MB) DATK and/or SP-Css ion-lock 1 peptides that replicate the functional biophysics of surfactant proteins (SP)-B and SP-C. Phospholipase-resistant phosphonolipids used in synthetic surfactants are DEPN-8 and PG-1, molecular analogs of dipalmitoyl phosphatidylcholine (DPPC) and palmitoyl-oleoyl phosphatidylglycerol (POPG), while glycerophospholipids used are active lipid components of native surfactant (DPPC:POPC:POPG 5:3:2 by weight)...
2016: PeerJ
https://www.readbyqxmd.com/read/27760357/effect-of-lung-surfactant-protein-sp-c-and-sp-c-promoted-membrane-fragmentation-on-cholesterol-dynamics
#14
Nuria Roldan, Thomas K M Nyholm, J Peter Slotte, Jesús Pérez-Gil, Begoña García-Álvarez
To allow breathing and prevent alveolar collapse, lung surfactant (LS) develops a complex membranous system at the respiratory surface. LS is defined by a specific protein and lipid composition, including saturated and unsaturated phospholipid species and cholesterol. Surfactant protein C (SP-C) has been suggested to be an essential element for sustaining the presence of cholesterol in surfactant without functional impairment. In this work, we used a fluorescent sterol-partitioning assay to assess the effect of the surfactant proteins SP-B and SP-C on cholesterol distribution in membranes...
October 18, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27703122/cocrystals-of-1-4-diethynylbenzene-with-1-3-diacetylbenzene-and-benzene-1-4-dicarbaldehyde-exhibiting-strong-nonconventional-alkyne-carbonyl-c-h-o-hydrogen-bonds-between-the-components
#15
Eric Bosch
Weak interactions between organic molecules are important in solid-state structures where the sum of the weaker interactions support the overall three-dimensional crystal structure. The sp-C-H...N hydrogen-bonding interaction is strong enough to promote the deliberate cocrystallization of a series of diynes with a series of dipyridines. It is also possible that a similar series of cocrystals could be formed between molecules containing a terminal alkyne and molecules which contain carbonyl O atoms as the potential hydrogen-bond acceptor...
October 1, 2016: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/27699176/effects-of-bufei-yishen-granules-combined-with-acupoint-sticking-therapy-on-pulmonary-surfactant-proteins-in-chronic-obstructive-pulmonary-disease-rats
#16
Yange Tian, Jiansheng Li, Ya Li, Yuqiong Dong, Fengjia Yao, Jing Mao, Linlin Li, Lili Wang, Shan Luo, Minghang Wang
Our previous studies have demonstrated the beneficial effects of Bufei Yishen granules combined with acupoint sticking therapy (the integrated therapy) in chronic obstructive pulmonary disease (COPD), but the underlying mechanism remains unclear. Dysfunction of pulmonary surfactant proteins (SPs, including SP-A, SP-B, SP-C, and SP-D) may be included in pathophysiology of COPD. This study aimed to explore the mechanism of the integrated therapy on SPs. COPD rat models were established. The treatment groups received Bufei Yishen granules or acupoint sticking or their combination...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27693601/lung-surfactant-function-and-composition-in-the-context-of-development-and-respiratory-physiology
#17
REVIEW
Wolfgang Bernhard
Lung surfactant is a complex with a unique phospholipid and protein composition. Its specific function is to reduce surface tension at the pulmonary air-liquid interface. The underlying Young-Laplace equation, applying to the surface of any geometrical structure, is the more important the smaller its radii are. It therefore applies to the alveoli and bronchioli of mature lungs, as well as to the tubules and saccules of immature lungs. Surfactant comprises 80% phosphatidylcholine (PC), of which dipalmitoyl-PC, palmitoyl-myristoyl-PC and palmitoyl-palmitoleoyl-PC together are 75%...
November 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27670912/fatal-respiratory-disease-due-to-a-homozygous-intronic-abca3-mutation-a-case-report
#18
Harry Pachajoa, Felipe Ruiz-Botero, Luis Enrique Meza-Escobar, Vania Alexandra Villota-Delgado, Adriana Ballesteros, Ivan Padilla, Diana Duarte
BACKGROUND: Pulmonary surfactant is a complex mixture of lipids and proteins. Mutations in surfactant protein-C, surfactant protein-D, and adenosine triphosphate-binding cassette subfamily A member 3 have been related to surfactant dysfunction and neonatal respiratory failure in full-term babies. Adenosine triphosphate-binding cassette subfamily A member 3 facilitates the transfer of lipids to lamellar bodies. We report the case of patient with a homozygous intronic ABCA3 mutation. CASE PRESENTATION: We describe a newborn full-term Colombian baby boy who was the son of non-consanguineous parents of mixed race ancestry (Mestizo), who was delivered with severe respiratory depression...
September 26, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27638906/the-unfolded-protein-response-controls-er-stress-induced-apoptosis-of-lung-epithelial-cells-through-angiotensin-generation
#19
Hang Nguyen, Bruce D Uhal
Recent work from this laboratory showed that endoplasmic reticulum (ER) stress-induced apoptosis of alveolar epithelial cells (AECs) is regulated by the autocrine angiotensin (ANG)II/ANG1-7 system. The proteasome inhibitor MG132 or surfactant protein C (SP-C) BRICHOS domain mutation G100S induced apoptosis in human AECs by activating the proapoptotic cathepsin D and reducing antiapoptotic angiotensin converting enzyme-2 (ACE-2). This study tested the hypothesis that ER stress-induced apoptosis of human AECs might be mediated by influence of the unfolded protein response (UPR) on the autocrine ANGII/ANG1-7 system...
November 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27596810/lung-epithelium-is-the-major-source-of-il-33-and-is-regulated-by-il-33-dependent-and-il-33-independent-mechanisms-in-pulmonary-cryptococcosis
#20
Laura Heyen, Uwe Müller, Sabine Siegemund, Bianca Schulze, Martina Protschka, Gottfried Alber, Daniel Piehler
Inhalation of the fungus Cryptococcus neoformans (C. neoformans) results in pulmonary cryptococcosis associated with IL-33-dependent type 2 immunity. Lung epithelium represents the initial contact site of infection. The role of IL-33 in type 2 immunity has been analyzed, but the source of this cytokine and its effect on lung epithelial cell function in pulmonary cryptococcosis remained unclear. In mice infected with C. neoformans, we identified alveolar type 2 epithelial cells as major source of IL-33. On both, IL-33-positive and IL-33-negative epithelial cells, IL-33 receptor expression was detectable...
September 4, 2016: Pathogens and Disease
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