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https://www.readbyqxmd.com/read/28834721/divide-conquer-surfactant-protein-sp-c-and-cholesterol-modulate-phase-segregation-in-lung-surfactant
#1
Nuria Roldan, Jesús Pérez-Gil, Michael R Morrow, Begoña García-Álvarez
Lung surfactant (LS) is an essential system supporting the respiratory function. Cholesterol can be deleterious for LS function, a condition that is reversed by the presence of the lipopeptide SP-C. In this work, the structure of LS-mimicking membranes has been analyzed under the combined effect of SP-C and cholesterol by deuterium NMR and phosphorus NMR and by electron spin resonance. Our results show that SP-C induces phase segregation at 37°C, resulting in an ordered phase with spectral features resembling an interdigitated state enriched in dipalmitoylphosphatidylcholine, a liquid-crystalline bilayer phase, and an extremely mobile phase consistent with small vesicles or micelles...
August 22, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28749493/sulfur-directed-carbon-sulfur-bond-cleavage-for-rh-catalyzed-regioselective-alkynylthiolation-of-alkynes
#2
Takanori Shibata, Akihito Mitake, Yosuke Akiyama, Kyalo Stephen Kanyiva
Sulfur-directed sp C-S bond cleavage along with a regioselective reaction with alkynes proceeded to give (Z)-enyne sulfides in high to excellent yields. Mechanistic studies were conducted, including characterization of an intermediate. An intramolecular variant realized the construction of a dibenzodithiepin skeleton, which is a seven-membered ring with two sulfur atoms.
August 8, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28746823/irx1-regulates-dental-outer-enamel-epithelial-and-lung-alveolar-type-ii-epithelial-differentiation
#3
Wenjie Yu, Xiao Li, Steven Eliason, Miguel Romero-Bustillos, Ryan J Ries, Huojun Cao, Brad A Amendt
The Iroquois genes (Irx) appear to regulate fundamental processes that lead to cell proliferation, differentiation, and maturation during development. In this report, the Iroquois homeobox 1 (Irx1) transcription factor was functionally disrupted using a LacZ insert and LacZ expression demonstrated stage-specific expression during embryogenesis. Irx1 is highly expressed in the brain, lung, digits, kidney, testis and developing teeth. Irx1 null mice are neonatal lethal and this lethality it due to pulmonary immaturity...
September 1, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28733146/resveratrol-efficiently-improves-pulmonary-function-via-stabilizing-mast-cells-in-a-rat-intestinal-injury-model
#4
Xiaolei Huang, Weicheng Zhao, Dan Hu, Xue Han, Hanbin Wang, Jianyu Yang, Yang Xu, Yuantao Li, Weifeng Yao, Chaojin Chen
BACKGROUND: Intestinal ischemia/reperfusion (IIR) leads to acute lung injury (ALI) distally by aggravating pulmonary oxidative stress. Resveratrol is effective in attenuating ALI through its antioxidant capacity. This study aimed to determine the effects of resveratrol on IIR-induced ALI and to explore the role of mast cells (MCs) activation in a rat model of IIR. METHODS: Adult Sprague-Dawley rats were subjected to IIR by occluding the superior mesenteric artery for 60min followed by 4-hour reperfusion...
September 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28725012/phycocyanin-attenuates-pulmonary-fibrosis-via-the-tlr2-myd88-nf-%C3%AE%C2%BAb-signaling-pathway
#5
Chengcheng Li, Yan Yu, Wenjun Li, Bo Liu, Xudong Jiao, Xinyu Song, Changjun Lv, Song Qin
Our aim was to investigate the effects of phycocyanin (PC) on bleomycin (BLM)-induced pulmonary fibrosis (PF). In this study, C57 BL/6 wild-type (WT) mice and toll-like receptor (TLR) 2 deficient mice were treated with PC for 28 days following BLM exposure. Serum and lung tissues were collected on days 3, 7 and 28. Data shows PC significantly decreased the levels of hydroxyproline (HYP), vimentin, surfactant-associated protein C (SP-C), fibroblast specific protein-1 (S100A4) and α-smooth muscle actin (α-SMA) but dramatically increased E-cadherin and podoplanin (PDPN) expression on day 28...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704044/new-scandium-borylimido-chemistry-synthesis-bonding-and-reactivity
#6
Benjamin A Clough, Simona Mellino, Eric Clot, Philip Mountford
We report a combined synthetic, mechanistic, and theoretical study of the first borylimido complex of a rare earth metal, (NacNac(NMe2))Sc{NB(NAr'CH)2} (25, Ar' = 2,6-C6H3(i)Pr2, NacNac(NMe2) = Ar'NC(Me)CHC(Me)NCH2CH2NMe2). Thermolysis of the methyl-borylamide (NacNac(NMe2))Sc(Me){NHB(NAr'CH)2} (18) generated transient imide 25 via rate-determining, first-order methane elimination (KIE ≈ 8.7). In the absence of external substrate, 25 underwent a reversible cyclometalation reaction (sp(3) C-H bond addition to Sc═Nimide) with a methyl group of the NacNac(NMe2) ligand forming {MeC(NC6H3(i)PrCH(Me)CH2)CHC(Me)NCH2CH2NMe2}Sc{NHB(NAr'CH)2} (21)...
August 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28661583/mno2-promoted-oxidative-radical-sulfonylation-of-haloalkynes-with-sulfonyl-hydrazides-c-sp-s-bond-formation-towards-alkynyl-sulfones
#7
Pengquan Chen, Chuanle Zhu, Rui Zhu, Wanqing Wu, Huanfeng Jiang
A catalyst-free oxidative radical sulfonylation of haloalkynes with sulfonyl hydrazides is reported. It represents an example of C(sp)-S bond formation using sulfonyl hydrazides as sulfonyl radical sources. Various alkynyl sulfones were synthesized in moderate to good yields. Having MnO2 as the oxidant is very critical for this transformation. Remarkably, the self-coupling reaction of haloalkynes through C(sp)-C(sp) bond formation is significantly inhibited under the standard reaction conditions.
June 29, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28657099/exploiting-the-dual-role-of-ethynylbenziodoxolones-in-gold-catalyzed-c-sp-c-sp-cross-coupling-reactions
#8
Somsuvra Banerjee, Nitin T Patil
Reported herein is the gold-catalyzed alkynylation of terminal alkynes using ethynylbenziodoxolones (EBXs), where EBXs serve a dual role as oxidants as well as alkyne transfer agents to access unsymmetrical 1,3-diynes. Hence, the catalytic system requires no external oxidants and is compatible with a broad range of substrates, including those with polar functional groups such as NH, OH and B(OH)2.
June 28, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28615099/-hyperoxia-modulates-the-expressions-of-c-ebp%C3%AE-and-pulmonary-surfactant-proteins-in-aecii-of-premature-rats
#9
Yanmin Lu, Hongyan Lu, Jiangyan Liu, Ming Chang, Qiuxia Wang, Wei Tang
Objective To explore the effect of hyperoxia on the expressions of CCAAT enhancer binding protein α (C/EBPα) and pulmonary surfactant proteins (SP-A, SP-B, SP-C, SP-D) and their correlations in primary type II alveolar epithelial cells (AECIIs) from premature rats. Methods AECIIs were divided into an air control group and a hyperoxia model group. The cells of the two groups were respectively exposed toair and 950 mL/L O2. The cells were harvested at 24, 48, and 72 hours after exposure. Inverted phase-contrast microscope was used to observe morphological changes of the cells...
June 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28610019/four-new-species-of-i-callibaetis-i-eaton-ephemeroptera-baetidae-nymphal-description-of-i-callibaetis-i-i-abaetetuba-i-fasciatus-pictet-and-keys-for-south-american-species-of-i-callibaetis-i
#10
Paulo Vilela Cruz, Frederico Falcão Salles, Neusa Hamada
The first phylogenetic study of Callibaetis Eaton indicated an unrevealed diversity in this genus, including four new species named as Callibaetis sp. A, B, C and D, and the undescribed nymph of Callibaetis (Abaetetuba) fasciatus (Pictet). Given that neither the nymph of C. (Ab.) fasciatus nor the four new species received a proper description, the objective of this study is to describe them. The nymph of C. (Ab.) fasciatus differs from the others species in the subgenus by the presence of one row of setae on basal part of inner-dorsal row of maxilla and metanotum without spines; Callibaetis sp...
April 5, 2017: Zootaxa
https://www.readbyqxmd.com/read/28587394/mir-206-inhibits-fn1-expression-and-proliferation-and-promotes-apoptosis-of-rat-type-ii-alveolar-epithelial-cells
#11
Jun Duan, Xiaoying Zhang, Sheng Zhang, Shaodong Hua, Zhichun Feng
Bronchopulmonary dysplasia (BPD) is a syndrome of respiratory distress caused by chronic lung injury, primarily in preterm infants. miR-206 and fibronectin 1 (FN1) are associated with the development of BPD. The present study used rat type II alveolar epithelial cells (AECII) to investigate the underlying mechanisms of BPD. AECII were isolated using a primary cell culture prior to alkaline phosphatase staining and immunofluorescence of surfactant protein C (SP-C). These were used to verify the presence of AECII...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28552795/rhukgf-ameliorates-protease-anti-protease-imbalance-in-emphysematous-mice
#12
Sudhir Kotnala, Amit Tyagi, Jai Prakash Muyal
We attempted to elucidate the beneficial role of rHuKGF supplementation in the amelioration of protease/antiprotease imbalance and TGF-β1 signaling pathway leading to alveolar tissue maintenance in elastase induced emphysematous mice. Thirty two male C57BL mice were divided into four groups i.e. control, emphysema, therapy and rHuKGF only and were oropharyngeally instilled with saline/porcine pancreatic elastase/rHuKGF. Subsequently, lungs from mice were collected for histopathology and molecular biology studies...
August 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28544742/gold-catalyzed-cadiot-chodkiewicz-type-cross-coupling-of-terminal-alkynes-with-alkynyl-hypervalent-iodine-reagents-highly-selective-synthesis-of-unsymmetrical-1-3-diynes
#13
Xiangdong Li, Xin Xie, Ning Sun, Yuanhong Liu
A new and efficient method for the synthesis of unsymmetrical 1,3-butadiynes by gold-catalyzed C(sp)-C(sp) cross-coupling of terminal alkynes with alkynyl hypervalent iodine(III) reagents has been developed. The reaction features high selectivity and efficiency, mild reaction conditions, wide substrate scope, and functional-group compatibility, and is a highly attractive complement to existing methods. Mechanistic studies reveal that formation of a phenanthrolinyl-ligated gold(I) complex is crucial for the efficiency and selectivity of the target transformation...
May 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28541666/unveiling-the-molecular-structure-of-pulmonary-surfactant-corona-on-nanoparticles
#14
Qinglin Hu, Xuan Bai, Guoqing Hu, Yi Y Zuo
The growing risk of human exposure to airborne nanoparticles (NPs) causes a general concern on the biosafety of nanotechnology. Inhaled NPs can deposit in the deep lung at which they interact with the pulmonary surfactant (PS). Despite the increasing study of nano-bio interactions, detailed molecular mechanisms by which inhaled NPs interact with the natural PS system remain unclear. Using coarse-grained molecular dynamics simulation, we studied the interaction between NPs and the PS system in the alveolar fluid...
July 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28540997/a-combination-of-short-and-simple-surfactant-protein-b-and-c-analogues-as-a-new-synthetic-surfactant-in-vitro-and-animal-experiments
#15
Yong Sung Choi, Sung Hoon Chung, Chong Woo Bae
PURPOSE: Pulmonary surfactants for preterm infants contain mostly animal-derived surfactant proteins (SPs), which are essential for lowering surface tension. We prepared artificial pulmonary surfactants using synthetic human SP analogs and performed in vitro and in vivo experiments. MATERIALS AND METHODS: We synthesized peptide analogues that resemble human SP-B (RMLPQLVCRLVLRCSMD) and SP-C (CPVHLKRLLLLLLLLLLLLLLLL). Dipalmitoylphosphatidylcholine (DPPC), phosphatidylglycerol (PG), and palmitic acid (PA) were added and mixed in lyophilized to render powdered surfactant...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28513734/strained-alkynes-derived-from-2-2-dihydroxy-1-1-biaryls-synthesis-and-copper-free-cycloaddition-with-azides
#16
Alessandro Del Grosso, Lavrentis-Dimitrios Galanopoulos, Cookson K C Chiu, Guy J Clarkson, Peter B O Connor, Martin Wills
A series of strained alkynes were prepared from 2,2'-dihydroxy-biaryls. Several were characterised by X-ray crystallography, revealing strained C(sp)-C(sp)-C(sp(3)) bond angles in the range of 163-167°. Their cycloadditions with azides proceed without a catalyst. Functionalised versions of these reagents have potential applications to materials synthesis and bioconjugations.
May 31, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28465315/a-first-in-human-clinical-study-of-a-new-sp-b-and-sp-c-enriched-synthetic-surfactant-chf5633-in-preterm-babies-with-respiratory-distress-syndrome
#17
David G Sweet, Mark A Turner, Zbyněk Straňák, Richard Plavka, Paul Clarke, Ben J Stenson, Dominique Singer, Rangmar Goelz, Laura Fabbri, Guido Varoli, Annalisa Piccinno, Debora Santoro, Christian P Speer
OBJECTIVE: CHF5633 (Chiesi Farmaceutici S.p.A., Parma, Italy) is the first fully synthetic surfactant enriched by peptide analogues of two human surfactant proteins. We planned to assess safety and tolerability of CHF5633 and explore preliminary efficacy. DESIGN: Multicentre cohort study. PATIENTS: Forty infants from 27(+0) to 33(+6) weeks gestation with respiratory distress syndrome requiring fraction of inspired oxygen (FiO2) ≥0.35 were treated with a single dose of CHF5633 within 48 hours after birth...
May 2, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28458456/immunohistochemical-characterization-of-urethane-induced-lung-tumors-in-cb6f1-tg-rash2-mice
#18
Tomoya Sano, Takeshi Watanabe, Yoshimasa Ishimura, Hisashi Anayama
The purpose of this study was to define the histopathological characteristics of pulmonary neoplastic lesions, especially focusing on the origin of tumor cells, in urethane-treated Tg rasH2 mice. Bronchiolar-alveolar adenomas/adenocarcinomas were observed in the lungs from all of the urethane-treated animals. Immunohistochemically, these tumors showed an alveolar epithelial type II (AE2) cell phenotype demonstrating positive staining of surfactant protein C (SP-C). Cells expressing Clara cell 10 (CC10), a Clara cell marker, were also observed in a scattered manner in some tumors...
April 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28458453/suppressive-effects-of-the-expectorant-drug-ambroxol-hydrochloride-on-quartz-induced-lung-inflammation-in-f344-rats
#19
Shohei Kanie, Masanao Yokohira, Keiko Yamakawa, Yuko Nakano-Narusawa, Shota Yoshida, Nozomi Hashimoto, Katsumi Imaida
Surfactant proteins (SPs) are essential to respiratory structure and function. The expectorant drug ambroxol hydrochloride is clinically prescribed to stimulate pulmonary surfactant and airway serous secretion. Therefore, ambroxol hydrochloride may affect SP production and pulmonary inflammation. Lung toxicity of fine particles of various materials has been examined previously in our in vivo bioassay using the intratracheal (i.t.) instillation approach. In the present study, we evaluated modulatory effects of ambroxol hydrochloride on quartz-induced lung inflammation in F344 rats...
April 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28436053/measuring-family-centred-practices-of-professionals-in-early-intervention-services-in-taiwan
#20
L-J Kang, R J Palisano, R J Simeonsson, A-W Hwang
BACKGROUND: Family-centred practices emphasize professional supports for forming partnerships with families in early intervention. The Measure of Processes of Care for Service Providers (MPOC-SP) measures the perceptions of paediatric service providers in supporting children and families. This study aimed to establish reliability of the Chinese version of the MPOC-SP (C-MPOC-SP) and to examine professional perceptions of family-centred practices in relation to professional discipline and years of experience...
September 2017: Child: Care, Health and Development
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