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https://www.readbyqxmd.com/read/27919433/sodc-modulates-ras-and-pkb-signaling-in-dictyostelium
#1
Boris Castillo, Seon-Hee Kim, Mujataba Sharief, Tong Sun, Lou W Kim
We have previously reported that the basal RasG activity is aberrantly high in cells lacking Superoxide dismutase C (SodC). Here we report that other Ras proteins such as RasC and RasD activities are not affected in sodC(-) cells and mutagenesis studies showed that the presence of the Cys(118) in the Ras proteins is essential for the superoxide-mediated activation of Ras proteins in Dictyostelium. In addition to the loss of SodC, lack of extracellular magnesium ions increased the level of intracellular superoxide and active RasG proteins...
November 30, 2016: European Journal of Cell Biology
https://www.readbyqxmd.com/read/26788709/impact-of-renal-sympathetic-denervation-on-cardiac-sympathetic-nerve-activity-evaluated-by-cardiac-mibg-imaging
#2
Andrius Berukstis, Donatas Vajauskas, Urte Gargalskaite, Nerijus Misonis, Greta Burneikaite, Diana Zakarkaite, Marius Miglinas, Aleksandras Laucevicius
AIMS: The objective of the present study was to investigate an effect of renal artery sympathetic denervation (RASD) on patients with resistant hypertension and RASD effect on cardiac sympathetic nerve activity. It is known that an abnormally activated sympathetic tone is associated with progression of heart failure (HF). METHODS AND RESULTS: We investigated 16 patients with resistant arterial hypertension (mean age 54.88±7.89 years, mean 24-hr ambulatory blood pressure [BP] systolic 161...
January 22, 2016: EuroIntervention
https://www.readbyqxmd.com/read/26424797/pp2a-b56-and-gsk3-ras-suppress-pkb-activity-during-dictyostelium-chemotaxis
#3
Marbelys Rodriguez Pino, Boris Castillo, Bohye Kim, Lou W Kim
We have previously shown that the Dictyostelium protein phosphatase 2A regulatory subunit B56, encoded by psrA, modulates Dictyostelium cell differentiation through negatively affecting glycogen synthase kinase 3 (GSK3) function. Our follow-up research uncovered that B56 preferentially associated with GDP forms of RasC and RasD, but not with RasG in vitro, and psrA(-) cells displayed inefficient activation of multiple Ras species, decreased random motility, and inefficient chemotaxis toward cAMP and folic acid gradient...
December 1, 2015: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/25938579/ultrafast-2d-ir-and-simulation-investigations-of-preferential-solvation-and-cosolvent-exchange-dynamics
#4
Josef A Dunbar, Evan J Arthur, Aaron M White, Kevin J Kubarych
Using a derivative of the vitamin biotin labeled with a transition-metal carbonyl vibrational probe in a series of aqueous N,N-dimethylformamide (DMF) solutions, we observe a striking slowdown in spectral diffusion dynamics with decreased DMF concentration. Equilibrium solvation dynamics, measured with the rapidly acquired spectral diffusion (RASD) technique, a variant of heterodyne-detected photon-echo peak shift experiments, range from 1 ps in neat DMF to ∼3 ps in 0.07 mole fraction DMF/water solution. Molecular dynamics simulations of the biotin-metal carbonyl solute in explicit aqueous DMF solutions show marked preferential solvation by DMF, which becomes more pronounced at lower DMF concentrations...
May 21, 2015: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/25937293/complication-rates-are-reduced-for-revision-adult-spine-deformity-surgery-among-high-volume-hospitals-and-surgeons
#5
Justin C Paul, Baron S Lonner, Vadim Goz, Jeffery Weinreb, Raj Karia, Courtney S Toombs, Thomas J Errico
BACKGROUND CONTEXT: Revision adult spinal deformity surgery (RASDS) is a particularly high-risk intervention. PURPOSE: The aim was to assess complication rates in RASDS by surgeon and hospital operative volume. STUDY DESIGN/SETTING: This was a retrospective analysis of prospectively collected data. PATIENT SAMPLE: Based on a Nationwide Inpatient Sample (NIS) database (2001-2010), patients aged older than 21 years (International Classification of Diseases, Ninth Revision, Clinical Modification) with spine arthrodesis for scoliosis were included...
September 1, 2015: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/24282234/developmental-lineage-priming-in-dictyostelium-by-heterogeneous-ras-activation
#6
Alex Chattwood, Koki Nagayama, Parvin Bolourani, Lauren Harkin, Marzieh Kamjoo, Gerald Weeks, Christopher R L Thompson
In cell culture, genetically identical cells often exhibit heterogeneous behavior, with only 'lineage primed' cells responding to differentiation inducing signals. It has recently been proposed that such heterogeneity exists during normal embryonic development to allow position independent patterning based on 'salt and pepper' differentiation and sorting out. However, the molecular basis of lineage priming and how it leads to reproducible cell type proportioning are poorly understood. To address this, we employed a novel forward genetic approach in the model organism Dictyostelium discoideum...
November 26, 2013: ELife
https://www.readbyqxmd.com/read/23651324/reticulated-acanthoma-with-sebaceous-differentiation-another-sebaceous-neoplasm-associated-with-muir-torre-syndrome
#7
Wonwoo Shon, Michael M Wolz, Catherine C Newman, Alina G Bridges
Reticulated acanthoma with sebaceous differentiation (RASD) represents a rare benign cutaneous epithelial neoplasm with sebaceous differentiation. There has been much speculation about the relationship between RASD and Muir-Torre syndrome (MTS). We report a 53 year-old man who presented with RASD in addition to a prior history of sebaceous adenomas. Immunohistochemically, the tumour cells in the RASD and sebaceous adenomas showed a significantly reduced MSH6 protein expression, whereas there was no loss of MLH1, MSH2 and PMS2...
November 2014: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/23231628/rapid-and-accurate-measurement-of-the-frequency-frequency-correlation-function
#8
Derek G Osborne, Kevin J Kubarych
Using an implementation of heterodyne-detected vibrational echo spectroscopy, we show that equilibrium spectral diffusion caused by solvation dynamics can be measured in a fraction of the time required using traditional two-dimensional infrared spectroscopy. Spectrally resolved, heterodyne-detected rephasing and nonrephasing signals, recorded at a single delay between the first two pulses in a photon echo sequence, can be used to measure the full waiting time dependent spectral dynamics that are typically extracted from a series of 2D-IR spectra...
July 25, 2013: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/22683505/striatum-specific-protein-rhes-regulates-akt-pathway
#9
Sookhee Bang, Catherine Steenstra, Sangwon F Kim
The Rhes/RASD2 GTPase complex is involved in dopamine D1/D2 receptor-mediated signaling and behavior. This GTP binding protein belongs to the RAS superfamily, along with Dexras1/RASD1, and is primarily expressed in the striatum. RASDs differ from typical small GTPases as they have an extended C-terminal tail of roughly 7 kDa. Previously, it has been shown that dopamine depletion reduces Rhes mRNA expression in the brain. Here we show that Rhes interacts with p85, the regulatory subunit of PI3K. Specifically, the C-terminal unique tail region of Rhes is responsible for this interaction...
July 19, 2012: Neuroscience Letters
https://www.readbyqxmd.com/read/20833893/ras-proteins-have-multiple-functions-in-vegetative-cells-of-dictyostelium
#10
Parvin Bolourani, George Spiegelman, Gerald Weeks
During the aggregation of Dictyostelium cells, signaling through RasG is more important in regulating cyclic AMP (cAMP) chemotaxis, whereas signaling through RasC is more important in regulating the cAMP relay. However, RasC is capable of substituting for RasG for chemotaxis, since rasG⁻ cells are only partially deficient in chemotaxis, whereas rasC⁻/rasG⁻ cells are totally incapable of chemotaxis. In this study we have examined the possible functional overlap between RasG and RasC in vegetative cells by comparing the vegetative cell properties of rasG⁻, rasC⁻, and rasC⁻/rasG⁻ cells...
November 2010: Eukaryotic Cell
https://www.readbyqxmd.com/read/20677347/right-anterior-segmental-hepatic-duct-emptying-directly-into-the-cystic-duct-in-a-living-donor
#11
Yasunao Ishiguro, Masanobu Hyodo, Takehito Fujiwara, Yasunaru Sakuma, Nobuyuki Hojo, Koichi Mizuta, Hideo Kawarasaki, Alan T Lefor, Yoshikazu Yasuda
A 35-year-old mother was scheduled to be the living donor for liver transplantation to her second son, who suffered from biliary atresia complicated with biliary cirrhosis at the age of 2 years. The operative plan was to recover the left lateral segment of the mother's liver for living donor transplantation. With the use of cholangiography at the time of surgery, we found the right anterior segmental duct (RASD) emptying directly into the cystic duct, and the catheter passed into the RASD. After repairing the incision in the cystic duct, transplantation was successfully performed...
August 7, 2010: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/20056453/reversed-arthroscopic-subacromial-decompression-for-symptomatic-irreparable-rotator-cuff-tears-mid-term-follow-up-results-in-34-shoulders
#12
COMPARATIVE STUDY
Luk Verhelst, Pieter-Jan Vandekerckhove, Gregory Sergeant, Koen Liekens, Petrus Van Hoonacker, Bart Berghs
BACKGROUND: In the elderly, there is no guideline for the treatment of irreparable rotator cuff lesions. The results of open or arthroscopic repair are variable. We hypothesized that the use of a reversed arthroscopic subacromial decompression (RASD) would yield comparable results. MATERIAL AND METHODS: Between January 2004 and December 2006, thirty-eight patients underwent a RASD for irreparable cuff tears in 39 shoulders. The surgical procedure consisted of a tenotomy of the long head of the biceps tendon, a debridement of the torn rotator cuff and a tuberoplasty, without violation of the coracoacromial arch and the acromion...
June 2010: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/19461247/reticulated-acanthoma-with-sebaceous-differentiation-lack-of-association-with-muir-torre-syndrome
#13
Dana L Haake, John P Minni, Michael Nowak, Pascual Abenoza, Carlos H Nousari
We hereby report a case of a reticulated acanthoma with sebaceous differentiation (RASD), a rare and often mislabeled benign lesion that is characterized by epidermal acanthosis and clusters of sebocytes in a reticulated seborrheic keratosis-like pattern. The presence of multiple sebaceous tumors, most notably cystic sebaceous adenomas and keratoacanthomas, has been associated with Muir-Torre syndrome (MTS). Although very rare, cases of RASD have been reported with MTS, which potentially offers profound clinical significance to this neoplasm...
June 2009: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/18700937/anatomic-variations-in-intrahepatic-bile-ducts-in-a-north-indian-population
#14
Vijay Sharma, Vivek Anand Saraswat, Sanjay Saran Baijal, Gourdas Choudhuri
BACKGROUND AND AIM: In the present study, we described the anatomical variations in the branching patterns of intrahepatic bile ducts (IHD) and determined the frequency of each variation in north Indian patients. There are no data from India. METHODS: The study group consisted of 253 consecutive patients (131 women) undergoing endoscopic retrograde cholangiograms for different indications. Anatomical variations in IHD were classified according to the branching pattern of the right anterior segmental duct (RASD) and the right posterior segmental duct (RPSD), presence or absence of first-order branch of left hepatic duct (LHD) and of an accessory hepatic duct...
July 2008: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/16735078/a-phototaxis-signalling-complex-in-dictyostelium-discoideum
#15
Esther Bandala-Sanchez, Sarah J Annesley, Paul R Fisher
Phototaxis has been studied in a variety of organisms belonging to all three major taxonomic domains - the bacteria, the archaea and the eukarya. Dictyostelium discoideum is one of a small number of eukaryotic organisms which are amenable to studying the signalling pathways involved in phototaxis. In this study we provide evidence based on protein coimmunoprecipitation for a phototaxis signalling complex in Dictyostelium that includes the proteins RasD, filamin, ErkB, GRP125 and PKB.
September 2006: European Journal of Cell Biology
https://www.readbyqxmd.com/read/16625081/reticulated-acanthoma-with-sebaceous-differentiation
#16
Kazuyoshi Fukai, Junko Sowa, Masamitsu Ishii
Reticulated acanthoma with sebaceous differentiation (RASD) is characterized by the reticulated proliferation of spinous cells with aggregates of mature sebocytes in the bases of the strands of the keratinocytes, often linking rete ridges. Here, we report the first case reported as RASD. A 55-year-old woman presented with a 15-year history of a slightly pruritic patch on the upper back, and the histology was typical for RASD. She had been bothered by a yellow discharge from the tumor. Skin tumors with sebaceous differentiation are occasionally associated with Muir-Torre syndrome...
April 2006: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/12845303/anatomic-variation-in-intrahepatic-bile-ducts-an-analysis-of-intraoperative-cholangiograms-in-300-consecutive-donors-for-living-donor-liver-transplantation
#17
Jin Woo Choi, Tae Kyoung Kim, Kyoung Won Kim, Ah Young Kim, Pyo Nyun Kim, Hyun Kwon Ha, Moon-Gyu Lee
OBJECTIVE: To describe the anatomical variation occurring in intrahepatic bile ducts (IHDs) in terms of their branching patterns, and to determine the frequency of each variation. MATERIALS AND METHODS: The study group consisted of 300 consecutive donors for liver transplantation who underwent intraoperative cholangiography. Anatomical variation in IHDs was classified according to the branching pattern of the right anterior and right posterior segmental duct (RASD and RPSD, respectively), and the presence or absence of the first-order branch of the left hepatic duct (LHD), and of an accessory hepatic duct...
April 2003: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/11222145/expression-of-activated-ras-during-dictyostelium-development-alters-cell-localization-and-changes-cell-fate
#18
Z M Jaffer, M Khosla, G B Spiegelman, G Weeks
There is now a body of evidence to indicate that Ras proteins play important roles in development. Dictyostelium expresses several ras genes and each appears to perform a distinct function. Previous data had indicated that the overexpression of an activated form of the major developmentally regulated gene, rasD, caused a major aberration in morphogenesis and cell type determination. We now show that the developmental expression of an activated rasG gene under the control of the rasD promoter causes a similar defect...
March 2001: Development
https://www.readbyqxmd.com/read/10837033/dictyostelium-rasd-is-required-for-normal-phototaxis-but-not-differentiation
#19
A Wilkins, M Khosla, D J Fraser, G B Spiegelman, P R Fisher, G Weeks, R H Insall
RasD, a Dictyostelium homolog of mammalian Ras, is maximally expressed during the multicellular stage of development. Normal Dictyostelium aggregates are phototactic and thermotactic, moving towards sources of light and heat with great sensitivity. We show that disruption of the gene for rasD causes a near-total loss of phototaxis and thermotaxis in mutant aggregates, without obvious effects on undirected movement. Previous experiments had suggested important roles for RasD in development and cell-type determination...
June 1, 2000: Genes & Development
https://www.readbyqxmd.com/read/10725225/functional-overlap-of-the-dictyostelium-rasg-rasd-and-rasb-proteins
#20
M Khosla, G B Spiegelman, R Insall, G Weeks
Disruption of the rasG gene in Dictyostelium discoideum results in several distinct phenotypes: a defect in cytokinesis, reduced motility and reduced growth. Reintroduction of the rasG gene restores all of the properties of the rasG(-) cells to those of the wild type. To determine whether the defects are due to impaired interactions with a single or multiple downstream effectors, we tested the ability of the highly related but non identical Dictyostelium ras genes, rasD and rasB, to rescue the defects. Introduction of the rasD gene under the control of the rasG promoter into rasG null (rasG(-)) cells corrected all phenotypes except the motility defect, suggesting that motility is regulated by a RasG mediated pathway that is different to those regulating growth or cytokinesis...
April 2000: Journal of Cell Science
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