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https://www.readbyqxmd.com/read/28454242/association-of-elevated-risk-of-pancreatic-cancer-in-diabetic-patients-a-systematic-review-and-meta-analysis
#1
Jiaxin Tan, Yu You, Fei Guo, Jianhua Xu, Haisu Dai, Ping Bie
Pancreatic cancer has a five-year overall survival rate <5%, a situation that has not improved since for 40 years. Diabetes mellitus including type 2 diabetes mellitus (T2D) is a suspected risk factor for the development of pancreatic cancer and nearly 45% of the pancreatic cancer cases are likely to present as new onset diabetes cases; however, the nature of association between T2D and pancreatic cancer is still controversial. In this meta-analysis, we examined the association specifically of T2D with pancreatic cancer and the influence of insulin therapy...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454089/p-akt-as-a-potential-poor-prognostic-factor-for-gastric-cancer-a-systematic-review-and-meta-analysis
#2
REVIEW
Fang Cao, Cong Zhang, Wei Han, Xiao-Jiao Gao, Jun Ma, Yong-Wei Hu, Xing Gu, Hou-Zhong Ding, Li-Xia Zhu, Qin Liu
To understand the relationship between p-Akt expression and the prognosis of patients with gastric cancer, we searched six databases, Pubmed, EMBASE, Cochrane Library, CNKI, Wanfang and CBM for relevant articles in order to conduct this metaanalysis. The pooled hazard ratios and corresponding 95%CI of overall survival were calculated to evaluate the prognostic value of p-Akt expression in patients with gastric cancer. With 2261 patients combined from 13 available studies, the pooled HR showed a poor prognosis in patients with gastric cancer in the univariate analysis (HR=1...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454050/forensic-genetic-analyses-in-isolated-populations-with-examples-of-central-european-valachs-and-roma
#3
REVIEW
Edvard Ehler, Daniel Vanek
Isolated populations present a constant threat to the correctness of forensic genetic casework. In this review article we present several examples of how analyzing samples from isolated populations can bias the results of the forensic statistics and analyses. We select our examples from isolated populations from central and southeastern Europe, namely the Valachs and the European Roma. We also provide the reader with general strategies and principles to improve the laboratory practice (best practice) and reporting of samples from supposedly isolated populations...
April 13, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28454042/cortical-plasticity-and-levodopa-induced-dyskinesias-in-parkinson-s-disease-connecting-the-dots-in-a-multicomponent-network
#4
REVIEW
Roopa Rajan, Traian Popa, Angelo Quartarone, Maria Felice Ghilardi, Asha Kishore
Levodopa-induced dyskinesias are motor complications following long term dopaminergic therapy in Parkinson's disease (PD). Impaired brain plasticity resulting in the creation of aberrant motor maps intended to encode normal voluntary movement is proposed to result in the development of dyskinesias. Traditionally, the various nodes in the motor network like the striato-cortical and the cerebello-thalamic loops were thought to function independent of each other with little communication among them. Anatomical evidence from primates revealed the existence of reciprocal loops between the basal ganglia and the cerebellum providing an anatomical basis for communication between the motor network loops...
April 10, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28454007/groundwater-remediation-from-the-past-to-the-future-a-bibliometric-analysis
#5
Shu Zhang, Guozhu Mao, John Crittenden, Xi Liu, Huibin Du
Groundwater is an important component of terrestrial ecosystems and plays a role in geochemical cycling. Groundwater is also used for agricultural irrigation and for the domestic supply of drinking water in most nations. However, groundwater contamination has led to many research efforts on groundwater remediation technologies and strategies. This study evaluated a total of 5486 groundwater remediation-related publications from 1995 to 2015 using bibliometric technology and social network analysis, to provide a quantitative analysis and a global view on the current research trend and future research directions...
January 19, 2017: Water Research
https://www.readbyqxmd.com/read/28453946/a-dermatologist-s-approach-to-genitourinary-syndrome-of-menopause
#6
Matthew Hum, Marlene Dytoc
BACKGROUND: Genitourinary syndrome of menopause (GSM) is a debilitating condition caused by hypoestrogenism that presents with vaginal dryness and dyspareunia as well as other genital, sexual, and urinary symptoms. Previously known as atrophic vaginitis, the term GSM is now used. OBJECTIVE: To help familiarise dermatologists with diagnosing and managing GSM. METHODS: In total, 218 articles were identified and reviewed by 2 independent authors using PubMed...
April 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28453908/sexual-dysfunction-in-subjects-treated-with-inhibitors-of-5%C3%AE-reductase-for-benign-prostatic-hyperplasia-a-comprehensive-review-and-meta-analysis
#7
REVIEW
G Corona, G Tirabassi, D Santi, E Maseroli, M Gacci, M Dicuio, A Sforza, E Mannucci, M Maggi
Despite their efficacy in the treatment of benign prostatic hyperplasia, the popularity of inhibitors of 5α-reductase (5ARIs) is limited by their association with adverse sexual side effects. The aim of this study was to review and meta-analyze currently available randomized clinical trials evaluating the rate of sexual side effects in men treated with 5ARIs. An extensive Medline Embase and Cochrane search was performed including the following words: 'finasteride', 'dutasteride', 'benign prostatic hyperplasia'...
April 28, 2017: Andrology
https://www.readbyqxmd.com/read/28453903/perfusion-monitoring-and-intraventricular-hemorrhage-in-preterm-infants
#8
Akio Ishiguro
Cardiovascular instability in preterm infants during the early postnatal period correlates with the development of intraventricular hemorrhage (IVH). Due to the correlation between hypotension and fluctuation of blood pressure, treatment especially aimed at hypotension has been attempted to prevent IVH. However, these attempts have seemed to result in failure. Recently, several novel perfusion markers have been found to be correlated with the development of IVH, and they are of current interest in cardiovascular management...
April 28, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28453761/the-prevalence-and-incidence-of-axial-and-peripheral-spondyloarthritis-in-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#9
Maren C Karreman, Jolanda J Luime, Johanna M W Hazes, Angelique E A M Weel
Background and Aims: Inflammatory bowel disease [IBD] is a chronic disease which affects up to 0.5% of the population. Various extraintestinal manifestations occur, among which are rheumatic manifestations, grouped together under the name spondyloarthritis. The objective of this systematic review and meta-analysis was to give a systematic overview of the prevalence and incidence of spondyloarthritis in patients with inflammatory bowel disease. Methods: We systematically searched Embase, Pubmed, OvidSP, Scopus, and Web-of-Science databases from inception to August 2016...
May 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28453714/evaluating-the-effect-of-integrated-microfinance-and-health-interventions-an-updated-review-of-the-evidence
#10
Lara M J Lorenzetti, Sheila Leatherman, Valerie L Flax
Background: Solutions delivered within firm sectoral boundaries are inadequate in achieving income security and better health for poor populations. Integrated microfinance and health interventions leverage networks of women to promote financial inclusion, build livelihoods, and safeguard against high cost illnesses. Our understanding of the effect of integrated interventions has been limited by variability in intervention, outcome, design, and methodological rigour. This systematic review synthesises the literature through 2015 to understand the effect of integrated microfinance and health programs...
June 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28453648/recent-advances-in-sequence-assembly-principles-and-applications
#11
Qingfeng Chen, Chaowang Lan, Liang Zhao, Jianxin Wang, Baoshan Chen, Yi-Ping Phoebe Chen
The application of advanced sequencing technologies and the rapid growth of various sequence data have led to increasing interest in DNA sequence assembly. However, repeats and polymorphism occur frequently in genomes, and each of these has different impacts on assembly. Further, many new applications for sequencing, such as metagenomics regarding multiple species, have emerged in recent years. These not only give rise to higher complexity but also prevent short-read assembly in an efficient way. This article reviews the theoretical foundations that underlie current mapping-based assembly and de novo-based assembly, and highlights the key issues and feasible solutions that need to be considered...
April 26, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/28453636/vitamin-d-status-and-all-cause-mortality-in-patients-with-chronic-kidney-disease-a-systematic-review-and-dose-response-meta-analysis
#12
Ahmad Jayedi, Sepideh Soltani, Sakineh Shab-Bidar
Context: Prevalence of vitamin D deficiency is high in patients with chronic kidney disease. Less attention has been paid to measurement and correction of serum level of 25(OH)D in these patients. Objective: We examined the association between different levels of serum 25(OH)D and risk of all-cause mortality in patients with chronic kidney disease. Data sources: Systematic search were done using MedLine and EMBASE from inception up to November 2016...
April 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28453627/patient-reported-physical-function-measures-in-cancer-clinical-trials
#13
Thomas M Atkinson, Angela M Stover, Daniel F Storfer, Rebecca M Saracino, Thomas A D'Agostino, Denise Pergolizzi, Konstantina Matsoukas, Yuelin Li, Ethan Basch
Patient-reported outcomes (PROs) are increasingly used to monitor treatment-related symptoms and physical function decrements in cancer clinical trials. As more patients enter survivorship, it is important to capture PRO physical function throughout trials to help restore pretreatment levels of function. We completed a systematic review of PRO physical function measures used in cancer clinical trials and evaluated their psychometric properties on the basis of guidelines from the US Food and Drug Administration...
April 27, 2017: Epidemiologic Reviews
https://www.readbyqxmd.com/read/28453547/a-systematic-review-of-hybrid-brain-computer-interfaces-taxonomy-and-usability-perspectives
#14
Inchul Choi, Ilsun Rhiu, Yushin Lee, Myung Hwan Yun, Chang S Nam
A new Brain-Computer Interface (BCI) technique, which is called a hybrid BCI, has recently been proposed to address the limitations of conventional single BCI system. Although some hybrid BCI studies have shown promising results, the field of hybrid BCI is still in its infancy and there is much to be done. Especially, since the hybrid BCI systems are so complicated and complex, it is difficult to understand the constituent and role of a hybrid BCI system at a glance. Also, the complicated and complex systems make it difficult to evaluate the usability of the systems...
2017: PloS One
https://www.readbyqxmd.com/read/28453534/vitamin-and-mineral-status-in-chronic-fatigue-syndrome-and-fibromyalgia-syndrome-a-systematic-review-and-meta-analysis
#15
Monica L Joustra, Isidor Minovic, Karin A M Janssens, Stephan J L Bakker, Judith G M Rosmalen
BACKGROUND: Many chronic fatigue syndrome (CFS) and fibromyalgia syndrome (FMS) patients (35-68%) use nutritional supplements, while it is unclear whether deficiencies in vitamins and minerals contribute to symptoms in these patients. Objectives were (1) to determine vitamin and mineral status in CFS and FMS patients as compared to healthy controls; (2) to investigate the association between vitamin and mineral status and clinical parameters, including symptom severity and quality of life; and (3) to determine the effect of supplementation on clinical parameters...
2017: PloS One
https://www.readbyqxmd.com/read/28453506/general-overview-and-treatment-recommendations-for-young-women-with-breast-cancer
#16
Domen Ribnikar, Ivica Ratoša, Andraž Perhavec, Eitan Amir
Breast cancer in young women is a complex disease to manage due to its biological heterogeneity and special issues related to toxicity of different treatment strategies. Defining a cut-off for young age has been challenging since it is not clear whether the prognostic effect of age is continuously variable or whether there are certain thresholds at which the prognosis changes (e.g. those < 50 years of age or ≤ 35 years of age). In this review article, we define young patients as those being premenopausal...
March 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28453448/cumulative-trauma-disorders-a-review
#17
Zaheen A Iqbal, Ahmad H Alghadir
BACKGROUND: Cumulative trauma disorder (CTD) is a term for various injuries of the musculoskeletal and nervous systems that are caused by repetitive tasks, forceful exertions, vibrations, mechanical compression or sustained postures. Although there are many studies citing incidence of CTDs, there are fewer articles about its etiology, pathology and management. OBJECTIVE: The aim of our study was to discuss the etiology, pathogenesis, prevention and management of CTDs...
April 21, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28453433/diagnostic-accuracy-of-selective-3-t-mr-neurography-guided-retroperitoneal-genitofemoral-nerve-blocks-for-the-diagnosis-of-genitofemoral-neuralgia
#18
Jan Fritz, A Lee Dellon, Eric H Williams, Gedge D Rosson, Allan J Belzberg, Frederick E Eckhauser
Purpose To determine if 3-T magnetic resonance (MR) neurography-guided retroperitoneal genitofemoral nerve (GFN) blocks are safe and effective for the diagnosis of genitofemoral neuralgia. Materials and Methods Following institutional review board approval and informed consent, 26 subjects (16 men, 10 women; mean age, 42 years [range, 24-78 years]; mean body mass index, 28 kg/m(2) [range, 20-35 kg/m(2)]) with intractable groin pain were included. By using a 3-T MR imaging system, intermediate-weighted turbo spin-echo pulse sequences, and MR-conditional needles, diagnostic MR neurography-guided GFN blocks were performed in the retroperitoneum...
April 28, 2017: Radiology
https://www.readbyqxmd.com/read/28453431/safety-and-efficacy-of-irreversible-electroporation-for-the-treatment-of-hepatocellular-carcinoma-not-amenable-to-thermal-ablation-techniques-a-retrospective-single-center-case-series
#19
Olivier Sutter, Joyce Calvo, Gisèle N'Kontchou, Jean-Charles Nault, Raffik Ourabia, Pierre Nahon, Nathalie Ganne-Carrié, Valérie Bourcier, Nora Zentar, Fatna Bouhafs, Nicolas Sellier, Abou Diallo, Olivier Seror
Purpose To assess the safety and efficacy of irreversible electroporation (IRE) in the treatment of patients with inoperable hepatocellular carcinoma (HCC) who are ineligible for thermal ablative techniques. Materials and Methods This retrospective study was approved by an ethics review board, and the requirement to obtain informed written consent was waived. From March 2012 to June 2015, 58 patients (median age, 65.4 years; range 41.6-90 years) with cirrhosis received IRE for the treatment of 75 HCC tumors...
April 28, 2017: Radiology
https://www.readbyqxmd.com/read/28453405/a-meta-analysis-of-antimicrobial-susceptibility-profiles-for-pneumococcal-pneumonia-in-sub-saharan-africa
#20
Pui-Ying Iroh Tam, Ayebo E Sadoh, Stephen K Obaro
BACKGROUND: Pneumonia causes an enormous burden of childhood disease globally, particularly in low- and middle-income countries. Pneumococcus is the most common bacterial aetiology of pneumonia; however, antimicrobials are limited and may not adequately address the local epidemiology of the region. AIM: To undertake a review and meta-analysis of pneumonia studies in sub-Saharan Africa to evaluate antimicrobial susceptibility patterns in childhood pneumonia. METHODS: Articles published in PubMed and Google between 2006 and 2016 which evaluated antimicrobial susceptibility profiles of pneumococcal pneumonia in children in sub-Saharan Africa were identified...
April 28, 2017: Paediatrics and International Child Health
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