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https://www.readbyqxmd.com/read/29908526/case-reports-of-five-cancer-patients-with-unusual-course
#1
Dietmar Payrhuber, Karin Thieves, Piero Sangaletti, Josef Muehlmann, Michael Frass
INTRODUCTION:  The analysis of the periodic table of elements by Jan Scholten opened the way for a new kind of classification and repertorisation of homeopathic remedies. Thereby, group analysis (resorting to series and stages) makes precise prescriptions possible. This approach appears to yield striking results, even in severe cases. Whereas Hahnemann stressed the emotional state ('Gemüthssymptome', Organon § 210) when choosing a remedy, Scholten 200 years later investigated the mental picture that represents a life conflict or even a life theme that may maintain the disease process...
June 16, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29908444/synthesis-and-biological-evaluation-of-novel-2-oxo-1-2-dihydroquinoline-4-carboxamide-derivatives-for-the-treatment-of-esophageal-squamous-cell-carcinoma
#2
Mai I Shahin, Joyeeta Roy, Maha Hanafi, Dongyao Wang, Urarika Luesakul, Yifeng Chai, Nongnuj Muangsin, Deena S Lasheen, Dalal A Abou El Ella, Khaled A Abouzid, Nouri Neamati
No new and effective treatments have been approved for the treatment of esophageal squamous cell carcinoma (ESCC) in the past decade. Cisplatin and 5-fluoruracil are the most commonly used drugs for this disease. In order to develop a new class of drugs effective in our ESCC phenotypic screens, we began a systematic approach to generate novel compounds based on the 2-oxo-1,2-dihydroquinoline-4-carboxamide fragment. Herein, we report on the synthesis and initial assessment of 55 new analogues in two ESCC cell lines...
May 29, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29908368/tag-synthesis-and-storage-under-osmotic-stress-a-requirement-for-preserving-membrane-homeostasis-in-renal-cells
#3
Karen Weber, Cecilia Casali, Virginia Gaveglio, Susana Pasquaré, Emanuel Morel Gómez, Leandro Parra, Luciana Erjavec, Cecilia Perazzo, María C Fernández Tome
Hyperosmolarity is a controversial signal for renal cells. It can induce cell stress or differentiation and both require an active lipid metabolism. We showed that hyperosmolarity upregulates phospholipid (PL) de novo synthesis in renal cells. PL synthesis requires fatty acids (FA), usually stored as triglycerides (TAG). PL and TAG de novo synthesis utilize the same initial biosynthetic route: sn-glycerol 3P (G3P) → phosphatidic acid (PA) → diacylglycerol (DAG). In the present work, we evaluate how such pathway contributes to PL and TAG synthesis in renal cells subjected to hyperosmolarity...
June 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29908210/the-tgf%C3%AE-induced-lncrna-tbila-promotes-non-small-cell-lung-cancer-progression-in-vitro-and-in-vivo-via-cis-regulating-hgal-and-activating-s100a7-jab1-signaling
#4
Zhiliang Lu, Yuan Li, Yun Che, Jianbing Huang, Shouguo Sun, Shuangshuang Mao, Yuanyuan Lei, Ning Li, Nan Sun, Jie He
Long non-coding RNAs (lncRNAs) play critical roles in multiple cellular processes in non-small cell lung cancer (NSCLC); however, the involvement of lncRNAs in the transforming growth factor-beta (TGFβ) signaling pathway, the critical tumor cell epithelial-mesenchymal transition (EMT) and metastasis pathway, remains poorly understood. To address this issue, we compared the lncRNAs expression patterns of NSCLC cells treated with and without TGFβ1 treatment. We observed that one of the most prominent hits, TGFβ-induced lncRNA (TBILA), promoted NSCLC progression and was upregulated in tumor tissues...
June 13, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29908209/the-second-generation-thiazolide-haloxanide-is-a-potent-inhibitor-of-avian-influenza-virus-replication
#5
Simone La Frazia, Sara Piacentini, Anna Riccio, Jean Francois Rossignol, M Gabriella Santoro
The emergence of new avian influenza virus (AIV) strains able to infect humans represents a serious threat to global human health. In addition to surveillance and vaccine development, antiviral therapy remains crucial for AIV control; however, the increase in drug-resistant AIV strains underscores the need for novel approaches to anti-influenza chemotherapy. We have previously shown that the thiazolide anti-infective nitazoxanide (NTZ) inhibits influenza A/PuertoRico/8/1934(H1N1) virus replication, and this effect was associated with inhibition of viral hemagglutinin (HA) maturation...
June 13, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29908123/cold-atmospheric-plasma-treatment-inhibits-growth-in-colorectal-cancer-cells
#6
Christin Schneider, Stephanie Arndt, Julia L Zimmermann, Yangfang Li, Sigrid Karrer, Anja-Katrin Bosserhoff
Plasma oncology is a relatively new field of research. Recent developments have indicated that cold atmospheric plasma (CAP) technology is an interesting new therapeutic approach to cancer treatment. In this study, p53 wildtype (LoVo) and human p53 mutated (HT29 and SW480) colorectal cancer cells were treated with the miniFlatPlaSter - a device particularly developed for the treatment of tumor cells - that uses the Surface Micro Discharge (SMD) technology for plasma production in air. The present study analyzed the effects of plasma on colorectal cancer cells in vitro and on normal colon tissue ex vivo...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29908121/pathological-manifestations-of-farber-disease-in-a-new-mouse-model
#7
Nadine Beckmann, Stephanie Kadow, Fabian Schumacher, Joachim R Göthert, Stefanie Kesper, Annette Draeger, Walter J Schulz-Schaeffer, Jiang Wang, Jan U Becker, Melanie Kramer, Claudine Kühn, Burkhard Kleuser, Katrin Anne Becker, Erich Gulbins
Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments are clinically available and affected patients have a severely shortened lifespan. Due to the low incidence, the pathogenesis of Farber Disease is still poorly understood. Here, we report a novel acid ceramidase mutant mouse model that enables the study of pathogenic mechanisms of Farber Disease and ceramide accumulation. Asah1tmEx1 mice were generated by deletion of the acid ceramidase signal peptide sequence...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29908036/acquired-von-willebrand-syndrome-in-congenital-heart-disease-surgery-results-from-an-observational-case-series
#8
Vanya Icheva, Martina Nowak-Machen, Ulrich Budde, Karl Jaschonek, Felix Neunhoeffer, Matthias Kumpf, Michael Hofbeck, Christian Schlensak, Gesa Wiegand
BACKGROUND: Cardiac surgery of the newborn and infant with complex congenital heart disease (CHD) is associated with a high rate of intraoperative bleeding complications. CHD-related anatomic features such as valve stenoses or patent arterial ducts can lead to enhanced shear stress in blood stream and thus cause acquired von Willebrand syndrome (aVWS). OBJECTIVE: To evaluate the intraoperative incidence and impact of aVWS after cardiopulmonary bypass (CPB) in neonates and infants with complex CHD...
June 16, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29907977/melatonin-induces-mechanisms-of-brain-resilience-against-neurodegeneration
#9
Rubén Corpas, Christian Griñán-Ferré, Verónica Palomera-Ávalos, David Porquet, Pablo García de Frutos, Silvia M Franciscato Cozzolino, Eduard Rodríguez-Farré, Mercè Pallàs, Coral Sanfeliu, Bárbara R Cardoso
Melatonin is an endogenous pleiotropic molecule which orchestrates regulatory functions and protective capacity against age-related ailments. The increase in circulating levels of melatonin through dietary supplements intensifies its health benefits. Investigations in animal models have shown that melatonin protects against Alzheimer's disease (AD)-like pathology, although clinical studies have not been conclusive. We hypothesized that melatonin induces changes in the brain that prevent or attenuate AD by increasing resilience...
June 15, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29907940/infection-and-recurrence-rates-of-the-c-qur-v-patch-%C3%A2-in-ventral-hernia-repairs
#10
D Cheng, L Bonato, C Leinkram
PURPOSE: Ventral hernias are a common surgical issue and a myriad of surgical mesh designs has been developed for their treatment. Many of these new mesh designs have not been extensively tested and their complications rates are largely unknown. The C-QUR V-Patch Mesh™ combines a unique knit construction polypropylene mesh with an omega-3 fatty acid coating. There has only previously been one reported study investigating this mesh. METHODS: A multicentre cohort study, with a single surgeon, of 168 consecutive patients with ventral hernias underwent repair using a standardized open pre-peritoneal approach with the novel C-QUR V-Patch Mesh™ between January 2013 and June 2015...
June 15, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29907893/semaglutide-s-c-once-weekly-in-type-2-diabetes-a-population-pharmacokinetic-analysis
#11
Kristin Cecilie Carlsson Petri, Steen Hvass Ingwersen, Anne Flint, Jeppe Zacho, Rune Viig Overgaard
INTRODUCTION: Semaglutide, a new treatment option approved for the treatment of patients with type 2 diabetes mellitus, is a glucagon-like peptide-1 receptor agonist to be injected subcutaneously once weekly. This analysis used a population pharmacokinetic model of semaglutide to identify clinically relevant covariates for exposure. METHODS: A total of 1612 patients with up to seven pharmacokinetic observations each were included in the analysis. All subjects had type 2 diabetes mellitus and were enrolled in one of five trials in the phase III development program for subcutaneous semaglutide once weekly (the SUSTAIN program)...
June 15, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29907890/impact-of-mast-cells-in-depression-disorder-inhibitory-effect-of-il-37-new-frontiers
#12
REVIEW
Pio Conti, Alessandro Caraffa, Gianpaolo Ronconi, Chiara M Conti, Spiros K Kritas, Filiberto Mastrangelo, Lucia Tettamanti, Theoharis C Theoharides
The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and thoughts is a major risk factor for several metabolic diseases and may influence the physiology of the body leading to depression. Depression, present in mastocytosis, is an important endogenous process that promotes the activation of meningeal cell receptors through a low-grade neurogenic chronic inflammation, and MCs...
June 16, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29907884/availability-and-affordability-of-essential-medicines-implications-for-global-diabetes-treatment
#13
REVIEW
David Beran, Margaret Ewen, Kasia Lipska, Irl B Hirsch, John S Yudkin
PURPOSE OF REVIEW: The purpose of this review is to highlight the key issues with regard to the value, affordability, and availability of diabetes treatments. RECENT FINDINGS: Many of the medicines needed to manage diabetes are available as generics and, if purchased appropriately, can be made affordable to many individuals and systems. With new treatments for diabetes, additional costs to individuals and systems need to be assessed in terms of added clinical benefit and financial impact...
June 16, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29907872/the-current-state-of-the-art-for-biological-therapies-and-new-small-molecules-in-inflammatory-bowel-disease
#14
REVIEW
Sudarshan Paramsothy, Adam K Rosenstein, Saurabh Mehandru, Jean-Frederic Colombel
The emergence of biologic therapies is arguably the greatest therapeutic advance in the care of inflammatory bowel disease (IBD) to date, allowing directed treatments targeted at highly specific molecules shown to play critical roles in disease pathogenesis, with advantages in potency and selectivity. Furthermore, a large number of new biologic and small-molecule therapies in IBD targeting a variety of pathways are at various stages of development that should soon lead to a dramatic expansion in our therapeutic armamentarium...
June 15, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29907737/paradoxical-reaction-in-a-patient-with-co-occurring-tuberculous-meningitis-and-pott-s-disease
#15
Talia Robledo-Gil, Kaoru Harada, Ichiro Ikuta, Merceditas Villanueva
BACKGROUND Paradoxical reactions to tuberculosis (TB) are clinical or radiological worsening of prior tuberculous lesions or the development of new lesions upon treatment with appropriate anti-tuberculosis therapy (ATT). This phenomenon has been described in both HIV-seropositive and HIV-seronegative patients. Although historically estimated to occur in 6-30% of HIV-seronegative patients with TB, the phenomenon is often under-recognized in the current era, particularly in countries of low TB prevalence. We describe a case of a TB paradoxical reaction affecting the CNS and spine in an HIV-seronegative individual who received clinical care in the U...
June 16, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29907549/real-world-evidence-in-safety-assessment-of-new-treatments
#16
Karin E Smedby, Sandra Eloranta
No abstract text is available yet for this article.
June 12, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29907544/impact-of-flt3-receptor-cd135-detection-by-flow-cytometry-on-clinical-outcome-of-adult-acute-myeloid-leukemia-patients
#17
Eman Z Kandeel, Ghada El Sayed, Nahla Elsharkawy, Dalia Negm Eldin, Hanan R Nassar, Dalia Ibrahiem, Randa Amin, Marwa Hanafi, Mohamed Khalil, Azza Kamel
BACKGROUND: The significance of FMS-like tyrosine kinase 3 (FLT3)-ITD mutation in acute myeloid leukemia (AML) prognosis has been well established. The aims of this study were to investigate the prognostic impact of the FLT3 protein (CD135) expression and its association with FLT3-ITD mutation, and to identify its role in minimal residual disease. PATIENTS AND METHODS: CD135 was measured by flow cytometry on leukemic blasts of 257 adults with de novo AML. High expression of CD135 ≥ 20% was correlated with clinical, laboratory, and other prognostic factors that influenced treatment outcome...
May 26, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29907456/state-of-the-art-analgesia-recent-developments-in-pharmacological-approaches-to-acute-pain-management-in-dogs-and-cats-part-1
#18
REVIEW
C A Bradbrook, L Clark
There has been considerable interest in acute pain management over recent years, focusing on pain assessment, pharmacological and non-pharmacological interventions. The evidence base for our clinical decision making and treatment of patients is increasing and becoming more robust. There is still a tendency to base some aspects of pain management on poor quality evidence and this requires further input in years to come. With new literature come new ideas and this review will detail the current knowledge base behind pharmacological management of acute pain in dogs and cats...
June 6, 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29907450/altered-maternal-and-placental-lipid-metabolism-and-fetal-fat-development-in-obesity-current-knowledge-and-advances-in-non-invasive-assessment
#19
Flavien Delhaes, Stephanie A Giza, Tianna Koreman, Genevieve Eastabrook, Charles A McKenzie, Samantha Bedell, Timothy R H Regnault, Barbra de Vrijer
Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The metabolic changes associated with maternal obesity and/or the consumption of a high-fat diet effecting maternal lipid profiles and metabolism have also been documented to specifically affect placental function and may underlie changes in fetal development and life course disease risk...
May 26, 2018: Placenta
https://www.readbyqxmd.com/read/29907425/repurposing-steroidogenesis-inhibitors-for-the-therapy-of-neuropsychiatric-disorders-promises-and-caveats
#20
REVIEW
Roberto Frau, Marco Bortolato
Steroids exert a profound influence on behavioral reactivity, by modulating the functions of most neurotransmitters and shaping the impact of stress and sex-related variables on neural processes. This background - as well as the observation that most neuroactive steroids (including sex hormones, glucocorticoids and neurosteroids) are synthetized and metabolized by overlapping enzymatic machineries - points to steroidogenic pathways as a powerful source of targets for neuropsychiatric disorders. Inhibitors of steroidogenic enzymes have been developed and approved for a broad range of genitourinary and endocrine dysfunctions, opening to new opportunities to repurpose these drugs for the treatment of mental problems...
May 11, 2018: Neuropharmacology
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