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https://www.readbyqxmd.com/read/28107780/myb12-and-myb22-play-essential-roles-in-proanthocyanidin-and-flavonol-synthesis-in-red-fleshed-apple-malus-sieversii-f-niedzwetzkyana
#1
Nan Wang, Haifeng Xu, Shenghui Jiang, Zongying Zhang, Ninglin Lu, Huarong Qiu, Changzhi Qu, Yicheng Wang, Shujing Wu, Xuesen Chen
Flavonoids are major polyphenol compounds in plant secondary metabolism. Compared with cultivated apples, wild red-fleshed apples (Malus sieversii f. niedzwetzkyana) are excellent resources because of their high flavonoid content. In this work, R6R6, R6R1 and R1R1 genotypes were identified in an F1 segregating population of M. sieversii f. niedzwetzkyana. Significant differences in flavonoid compositions and contents were detected among the three genotypes by UPLC-ESI-TOF/MS analysis. Furthermore, two putative flavonoid-related genes encoding R2R3-MYB transcription factors, designated MYB12 and MYB22, were cloned and characterized...
January 20, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28107698/the-natural-flavonoid-apigenin-sensitizes-human-cd44-prostate-cancer-stem-cells-to-cisplatin-therapy
#2
Suat Erdogan, Kader Turkekul, Rıza Serttas, Zeynep Erdogan
Prostate cancer (PCa) is the second most common type of cancer and the fifth leading cause of cancer-related death among men. Development of chemoresistance, tumor relapse and metastasis remain major barriers to effective treatment and all been identified to be associated with cancer stem cells (CSCs). Natural flavonoids such as apigenin have been shown to have the ability to improve the therapeutic efficacy of common chemotherapy agents through CSCs sensitization. Thus, the aim of this study was to evaluate the combination of apigenin with cisplatin on CD44(+) PCa stem cell growth and migration...
January 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28106756/inhibitory-effects-of-constituents-from-the-aerial-parts-of-rosmarinus-officinalis-l-on-triglyceride-accumulation
#3
Jian Li, Tiwalade Adegoke Adelakun, Sijian Wang, Jingya Ruan, Shengcai Yang, Xiaoxia Li, Yi Zhang, Tao Wang
Sixteen flavonoids (1-16) including two new ones, named officinoflavonosides A (1) and B (2) were obtained from the aerial parts of Rosmarinus officinalis. Among the known ones, 6, 10, and 13 were isolated from the rosmarinus genus for the first time. Their structures were elucidated by chemical and spectroscopic methods. Moreover, the effects on sodium oleate-induced triglyceride accumulation (TG) in HepG2 cells of the above-mentioned compounds and 16 other isolates (17-32) reported previously to have been obtained in the plant were analyzed...
January 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28106710/banana-passion-fruit-passiflora-mollissima-kunth-l-h-bailey-microencapsulation-phytochemical-composition-and-antioxidant-capacity
#4
Almudena García-Ruiz, Amadeo Girones-Vilaplana, Paola León, Diego A Moreno, Carla M Stinco, Antonio J Meléndez-Martínez, Jenny Ruales
Passiflora mollissima (Kunth) L.H. Bailey is an exotic fruit native to South America, known as taxo in Ecuador. This paper characterizes its flavonoid and carotenoid composition and antioxidant capacity and evaluates the effect of the spray-drying process on its phytochemical composition and antioxidant capacity. A total of 18 flavonoid compounds, nine proanthocyanidins and nine flavan-3-ol monomers, were identified and quantified. Glycosides of (epi)-afzelechin stood out as the most abundant flavonoid. Three carotenoids were identified, with β-carotene having the highest concentration...
January 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28106344/fast-separation-of-flavonoids-by-supercritical-fluid-chromatography-using-a-column-packed-with-a-sub-2%C3%A2-%C3%AE-m-particle-stationary-phase
#5
Bo Wang, Xiao-Hua Liu, Wei Zhou, Yan Hong, Shi-Lan Feng
The purpose of this study was to compare the effects of different chromatographic columns for the separation of seven flavonoids. Four different stationary phases are available, including BEH, BEH 2-EP, CSH fluorophenyl and HSS C18 SB. The analytes included calycosin, genistein, medicarpin, calycosin-7-O-β-d-glucoside, formononetin, formononetin-7-O-β-d-glucoside and liquiritigenin. The CSH fluorophenyl column was determined to be the most suitable and provided the fastest separation within 17 min using gradient elution with carbon dioxide as the mobile phase and methanol as the co-solvent...
January 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28105652/lsp1-a-responsive-protein-from-meyerozyma-guilliermondii-elicits-defence-response-and-improves-glycyrrhizic-acid-biosynthesis-in-glycyrrhiza-uralensis-fisch-adventitious-roots
#6
Juan Wang, Jianli Li, Jing Li, Jinxin Li, Shujie Liu, Wenyuan Gao
This research explored the effects of protein and polysaccharide in Meyerozyma guilliermondii on active compounds in Glycyrrhiza uralensis Fisch adventitious roots. In this study, a responsive protein LSP1 was purified from the Meyerozyma guilliermondii since the excellent induction. The contents of total flavonoids (3.46 mg · g(-1) ), glycyrrhizic acid (0.41 mg · g(-1) ), glycyrrhetinic acid (0.41 mg · g(-1) ) and polysaccharide (94.49 mg · g(-1) ) in adventitious root peaked at LSP1 group, which were 1...
January 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28105507/worldwide-poly-phenol-intake-assessment-methods-and-identified-gaps
#7
REVIEW
Paula Pinto, Cláudia N Santos
INTRODUCTION: (Poly)phenols (PPs) are plant secondary metabolites widely distributed in dietary sources, and several evidences show that consumption of PP has a positive impact in human health. However, the correct estimation of food intake and the estimation of PP content of foods are essential to associate PPs intake with health effects. PURPOSE: This review aimed to gather information from several studies on PP intake in different countries, compare methods used for both assessment of food intake and PP quantification and highlight existing gaps and future directions...
January 19, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28105237/xanthohumol-inhibits-proliferation-of-laryngeal-squamous-cell-carcinoma
#8
Yan Li, Kai Wang, Shankai Yin, Hongliang Zheng, Daliu Min
Xanthohumol is a flavonoid compound that exhibits antioxidant and anticancer effects, and is used to treat atherosclerosis. The aim of the present study was to investigate the effect of xanthohumol on the cell proliferation of laryngeal squamous cell carcinoma and to understand the mechanism of its action. The effects of xanthohumol on the cell viability and apoptosis rate of laryngeal squamous cell carcinoma SCC4 cells were assessed by Annexin V-fluorescein isothiocyanate/propidium iodide staining. In addition, the expression levels of pro-apoptotic proteins, caspase-3, caspase-8, caspase-9, poly ADP ribose polymerase (PARP) p53 and apoptosis-inducing factor (AIF), as well as anti-apoptotic markers, B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia 1 (Mcl-1), were analyzed by western blotting...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105204/combining-fisetin-and-ionizing-radiation-suppresses-the-growth-of-mammalian-colorectal-cancers-in-xenograft-tumor-models
#9
Jyh-Der Leu, Bo-Shen Wang, Shu-Jun Chiu, Chun-Yuan Chang, Chien-Chih Chen, Fu-Du Chen, Shiirevnyamba Avirmed, Yi-Jang Lee
Fisetin (3,7,3',4'-tetrahydroxyflavone), which belongs to the flavonoid group of polyphenols and is found in a wide range of plants, has been reported to exhibit a number of biological activities in human cancer cells, including antioxidant, anti-inflammatory, antiangiogenic, anti-invasive and antiproliferative effects. Although previous in vitro studies have shown that fisetin treatment increases the apoptotic rate and enhances the radiosensitivity of human colorectal cancer cells, the in vivo effects of fisetin on tumor growth remain unclear...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105189/chrysin-induces-cell-apoptosis-in-human-uveal-melanoma-cells-via-intrinsic-apoptosis
#10
Chunyan Xue, Yueqin Chen, Dan-Ning Hu, Codrin Iacob, Chengwei Lu, Zhenping Huang
Uveal melanoma is the most common intraocular malignant tumor in adults. Chrysin is a flavonoid present in honey, propolis, various plants and herbs. In the present study, the cytotoxic effects of chrysin were investigated on human uveal melanoma cell lines (M17 and SP6.5) and associated signaling pathways, and a comparison to the effects on normal ocular cells [scleral fibroblasts and retinal pigment epithelial (RPE) cells] was performed. The effects of chrysin on cell viability were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104366/effects-of-acute-and-chronic-quercetin-administration-on-methylphenidate-induced-hyperlocomotion-and-oxidative-stress
#11
Luiz K S Kanazawa, Débora D Vecchia, Etiéli M Wendler, Palloma de A S Hocayen, Paulo S Berão, Manuela L de Mélo, Francislaine A Dos Reis Lívero, Claudia Rita Corso, Maria Carolina Stipp, Alexandra Acco, Roberto Andreatini
AIMS: Increases in protein kinase C (PKC) and oxidative stress have been related to mania. Drugs with antioxidant effects or inhibitory actions on PKC may have antimanic effects. The flavonoid quercetin has antioxidant and PKC-inhibiting effects that resemble those of lithium, the first-line treatment for mania in bipolar disorder. We hypothesized that quercetin may have antimanic-like effects in an animal model. MAIN METHODS: In the present study, we investigated the effects of acute and chronic treatment with quercetin (2...
January 16, 2017: Life Sciences
https://www.readbyqxmd.com/read/28103873/masquelier-s-grape-seed-extract-from-basic-flavonoid-research-to-a-well-characterized-food-supplement-with-health-benefits
#12
REVIEW
Antje R Weseler, Aalt Bast
Careful characterization and standardization of the composition of plant-derived food supplements is essential to establish a cause-effect relationship between the intake of that product and its health effect. In this review we follow a specific grape seed extract containing monomeric and oligomeric flavan-3-ols from its creation by Jack Masquelier in 1947 towards a botanical remedy and nutraceutical with proven health benefits. The preparation's research history parallels the advancing insights in the fields of molecular biology, medicine, plant and nutritional sciences during the last 70 years...
January 19, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28103863/pharmacological-profile-of-the-aerial-parts-of-rubus-ulmifolius-schott
#13
Niaz Ali, Mohammad Shaoib, Syed Wadood Ali Shah, Ismail Shah, Muhammad Shuaib
BACKGROUND: As aerial parts of Rubus ulmifolius contains phytochemicals like flavonoids and tannins. And whereas flavonoids and tannins have antioxidant and antipyretic activity, hence, current work is carried out to screen crude methanolic extract of aerial parts of Rubus ulmifolius (Ru.Cr) and crude flavonoids rich extract of Rubus ulmifolius (Ru.F) for possible antioxidant and antipyretic activity. Ru.Cr and Ru.F are also tested for brine shrimps lethality bioassay. Ru.F is tested for the first time for possible antioxidant and antipyretic activity...
January 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28103857/ameliorative-potential-of-alstonia-scholaris-linn-r-br-against-chronic-constriction-injury-induced-neuropathic-pain-in-rats
#14
Hasandeep Singh, Rohit Arora, Saroj Arora, Balbir Singh
BACKGROUND: Alstonia scholaris commonly known as 'Saptaparni' is an Indian traditional medicinal plant used in Ayurveda. It is commonly used to treat various disorders like asthma, bronchitis, diarrhea, dysentery and malaria. In folklore medicine the milky juice of the plant is applied on wounds and ulcers to treat pain, ear ache and also in rheumatic pains. AIM: The present study was designed to investigate the potential of A. scholaris R. Br. in chronic constriction injury of sciatic nerve (CCI) induced neuropathic pain in rats...
January 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28102295/bioactive-compounds-and-antioxidant-activity-of-wolfberry-infusion
#15
Yujing Sun, Japaer Rukeya, Wenyang Tao, Peilong Sun, Xingqian Ye
An infusion of the wolfberry (Lycium barbarum L.) is a traditional Asian herbal tea. This is the most commonly consumed form of dried wolfberry worldwide, yet little scientific information on wolfberry infusions is available. We investigated the effects of making infusions with hot water on the color, the content of bioactive compounds (polysaccharides, polyphenols, flavonoids and carotenoids) and the antioxidant ability of wolfberry infusions. The contents of bioactive compounds and the antioxidant activity of a wolfberry infusion increased with increased infusion temperature and time...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102022/the-flavonoid-7-4-dihydroxyflavone-prevents-dexamethasone-paradoxical-adverse-effect-on-eotaxin-production-by-human-fibroblasts
#16
Changda Liu, Nan Yang, Xiaoke Chen, Jody Tversky, Jixun Zhan, Mirna Chehade, Rachel L Miller, Xiu-Min Li
Eotaxin/CCL-11 is a major chemoattractant that contributes to eosinophilic inflammation in asthma. Glucocorticoids inhibit inflammation, but long-time exposure may cause paradoxical adverse effects by augmenting eotaxin/CCL-11production. The aim of this study was to determine if 7,4'-dihydroxyflavone (7,4'-DHF), the eotaxin/CCL11 inhibitor isolated from Glycyrrhiza uralensis, reduces in vitro eotaxin production induced by long-time dexamethasone (Dex) exposure, and if so, to elucidate the mechanisms of this inhibition...
January 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28101823/biological-activities-of-asteraceae-achillea-millefolium-and-calendula-officinalis-and-lamiaceae-melissa-officinalis-and-origanum-majorana-plant-extracts
#17
Mónica R García-Risco, Lamia Mouhid, Lilia Salas-Pérez, Alexis López-Padilla, Susana Santoyo, Laura Jaime, Ana Ramírez de Molina, Guillermo Reglero, Tiziana Fornari
Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) extracts were obtained by applying two sequential extraction processes: supercritical fluid extraction with carbon dioxide, followed by ultrasonic assisted extraction using green solvents (ethanol and ethanol:water 50:50). The extracts were analyzed in terms of the total content of phenolic compounds and the content of flavonoids; the volatile oil composition of supercritical extracts was analyzed by gas chromatography and the antioxidant capacity and cell toxicity was determined...
January 18, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28101737/spatholobus-suberectus-dunn-constituents-inhibit-sortase-a-and-staphylococcus-aureus-cell-clumping-to-fibrinogen
#18
Hyunjoo Cho, Beomkoo Chung, Chang-Kwon Kim, Dong-Chan Oh, Ki-Bong Oh, Jongheon Shin
Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. In Staphylococcus aureus (S. aureus), deletion of sortase isoform results in a significant reduction in virulence and infection potential. Twenty flavonoids were isolated from the stem of the folk medicinal plant Spatholobus suberectus Dunn. These compounds were tested against S. aureus-derived sortase A (SrtA), a key transpeptidase for bacterial virulence...
January 18, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28101238/diosmetin-triggers-cell-apoptosis-by-activation-of-the-p53-bcl-2-pathway-and-inactivation-of-the-notch3-nf-%C3%AE%C2%BAb-pathway-in-hepg2-cells
#19
Jie Qiao, Jie Liu, Kaiqiao Jia, Ning Li, Bin Liu, Qingyu Zhang, Runzhi Zhu
Diosmetin (DIOS), a flavonoid compound, is abundant in Citrus limon. Emerging studies have shown that DIOS is an effective compound implicated in multiple types of cancer. However, whether DIOS serves a role in hepatocellular carcinoma (HCC) is still obscure. HepG2 cells were used in the present study, and it was observed that DIOS exhibited antitumor activity against liver cancer cells. Western blotting was performed to evaluate cell apoptosis and survival-associated proteins, and the results demonstrated that DIOS treatment resulted in the activation of the p53-dependent apoptosis pathway...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28101184/anti-inflammatory-effects-of-luteolin-on-experimental-autoimmune-thyroiditis-in-mice
#20
Nan Xia, Gang Chen, Min Liu, Xiaozhen Ye, Yahui Pan, Jiuyu Ge, Yanting Mao, Hongwei Wang, Jian Wang, Sijing Xie
Hashimoto's thyroiditis (HT) is the most common organ-specific autoimmune disease and is believed to be a predominately T cell-mediated autoimmunity. Signal transducer and activator of transcription (STAT)3 is a crucial transcription factor of T cell-mediated immunity, with key roles in the proliferation and migration of T helper (Th) cells, differentiation of Th cells into Th17 cells, and the balance between Treg cells and Th17 cells. Flavonoid luteolin has been shown to markedly inhibit Tyr705 activation/phosphorylation of STAT3 and exert anti-inflammatory effects in multiple sclerosis...
December 2016: Experimental and Therapeutic Medicine
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