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https://www.readbyqxmd.com/read/28238891/appetite-suppressing-effect-of-spinacia-oleracea-in-rats-involvement-of-the-short-term-satiety-signal-cholecystokinin
#1
Vandana Panda, Priyanka Shinde
Spinacia oleracea (spinach) is a green leafy vegetable rich in antioxidant phyto-constituents such as flavonoids, polyphenols, carotenoids and vitamins. Fruits and vegetables rich in flavonoids are known to prevent weight gain by inducing satiety. The present study evaluates the appetite suppressing effect of a flavonoid rich extract of the spinach leaf (SOE) in rats. HPTLC of SOE was performed for detecting flavonoids. Rats were administered SOE (200 mg/kg and 400 mg/kg, p. o) and fluoxetine (6 mg/kg i...
February 23, 2017: Appetite
https://www.readbyqxmd.com/read/28238827/rhizoma-smilacis-glabrae-inhibits-pathogen-induced-upper-genital-tract-inflammation-in-rats-through-suppression-of-nf-%C3%AE%C2%BAb-pathway
#2
Wei Zou, Hougang Zhou, Jian Hu, Li Zhang, Qiue Tang, Xiaoke Wen, Zuoqi Xiao, Wei Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Rhizoma Smilacis Glabrae (RSG) is traditionally used to treat gynecological disease, which is simply recorded in Chinese Pharmacopoeia. However, whether it has effect on upper genital tract inflammation (UGTI) is unclear. AIM OF THE STUDY: To evaluate the pharmacological effect of RSG on UGTI in rats and analyze its phytochemistry characteristics. MATERIALS AND METHODS: The substances in RSG extract was qualified by LC-Q-TOF-MS method, and 11 substances were further quantified...
February 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28237914/apigenin-attenuates-hippocampal-oxidative-events-inflammation-and-pathological-alterations-in-rats-fed-high-fat-fructose-diet
#3
Jagan Kalivarathan, Sathiya Priya Chandrasekaran, Kalpana Kalaivanan, Vidhya Ramachandran, Anuradha Carani Venkatraman
High calorie diet promotes oxidative stress and chronic low grade inflammation that predispose to brain dysfunction and neurodegeneration. Hippocampus region of the brain has been shown to be particularly sensitive to high calorie diet. We hypothesize that apigenin (API), a flavonoid could attenuate hippocampal derangements induced by high fat-high fructose diet (HFFD). In this study, we investigated the effects of API on oxidative stress and inflammation in the hippocampus, and compared with those of sitagliptin (STG), a standard drug with neuroprotective properties...
February 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28237856/wogonin-a-plant-derived-small-molecule-exerts-potent-anti-inflammatory-and-chondroprotective-effects-through-the-activation-of-ros-erk-nrf2-signaling-pathways-in-human-osteoarthritis-chondrocytes
#4
Nazir M Khan, Abdul Haseeb, Mohammad Y Ansari, Pratap Devarapalli, Sara Haynie, Tariq M Haqqi
Osteoarthritis (OA), characterized by progressive destruction of articular cartilage, is the most common form of human arthritis. Here, we evaluated the potential chondroprotective and anti-inflammatory effects of Wogonin, a naturally occurring flavonoid, in IL-1β-stimulated human OA chondrocytes and cartilage explants. Wogonin completely suppressed the expression and production of inflammatory mediators including IL-6, COX-2, PGE2, iNOS and NO in IL-1β-stimulated OA chondrocytes. Further, Wogonin exhibits potent chondroprotective potential by switching the signaling axis of matrix degradation from catabolic towards anabolic ends and inhibited the expression, production and activities of matrix degrading proteases including MMP-13, MMP-3, MMP-9, and ADAMTS-4 in OA chondrocytes, and blocked the release of s-GAG and COL2A1 in IL-1β-stimulated OA cartilage explants...
February 22, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28237818/quercetin-inhibits-acid-sensing-ion-channels-through-a-putative-binding-site-in-the-central-vestibular-region
#5
Mohona Mukhopadhyay, Anurag Singh, S Sachchidanand, Amal Kanti Bera
Acid-sensing ion channels (ASICs) are associated with many pathophysiological processes, such as neuronal death during ischemic stroke, epileptic seizure and nociception. However, there is a dearth of ASIC-specific therapeutic blockers. Here we report that quercetin, a plant flavonoid, which is known for its neuroprotective effect, reversibly inhibits homomeric rat ASIC1a, ASIC2a and ASIC3 with an IC50 of about 2 µM. Also, quercetin prevents low pH-induced intracellular calcium rise and cell death in HEK-293 cells, which have endogenous expression of ASIC1a and 2a...
February 22, 2017: Neuroscience
https://www.readbyqxmd.com/read/28237473/phytochemical-and-ethnopharmacological-review-of-elephantorrhiza-goetzei-harms-harms
#6
REVIEW
Alfred Maroyi
Elephantorrhiza goetzei (E. goetzei) commonly known as Goetze's elephantorrhiza, is traditionally used as a decoction in the treatment of a variety of conditions such as pain, sores, sexually transmitted infections (STIs), gastro-intestinal disorders, microbial infections and genito-urinary system disorders. On the basis of its wide distribution in south central Africa, E. goetzei has a long history of applications among the different ethnic groups. A total of 23 ethnomedicinal uses of E. goetzei are documented in this study from 62...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28236787/apigenin-7-o-glucoside-oxidation-catalyzed-by-p450-bioinspired-systems
#7
Lucas B Bolzon, Joicy S Dos Santos, Denise B Silva, Eduardo J Crevelin, Luiz A B Moraes, Norberto P Lopes, Marilda D Assis
Apigenin-7-O-glucoside (A7G) is the main flavonoid of Bidens gardneri Bak., a Brazilian plant with wide application in folk medicine. Despite the popular use of this plant, its biological effects are not completely known. This work tested the 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin iron(III) and manganese(III) chloride (Fe(TFPP)Cl and Mn(TFPP)Cl), and Jacobsen's catalyst as P450-bioinspired catalysts for A7G oxidation by different oxidants (PhIO, H2O2, m-CPBA, and t-BuOOH). Up to nine different products were detected by HPLC analysis; Reactions with metalloporphyrin/PhIO systems afforded high catalytic conversions (58-89%)...
February 20, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28236705/protective-effects-of-total-flavonoids-in-caragana-against-hypoxia-reoxygenation-induced-injury-in-human-brain-microvascular-endothelial-cells
#8
Qian-Song He, Li Zhang, Zi-Yuan Fan, Guo Feng, Fu-Jiang Wang, Zheng-Qi Liu, Ting Tang, Shi-Xiang Kuang
This study aimed to explore the protective effect of total flavonoids in Caragana against hypoxia/reoxygenation (H/R)-induced injury in human brain microvascular endothelial cells (BMECs). Human BMECs were selected and assigned into control, H/R, H/R+NMP, H/R+Low dose, H/R+Moderate dose, H/R+High dose groups. MTT and Transwell assays were used to detect cell viability and migration, respectively. Cell adhesion rate and tube formation were also detected. Real-time polymerase chain reaction (RT-PCR) and Western blotting were performed to test HIF-1α, VEGF and Notch1 mRNA and protein expressions...
February 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28236591/chemical-constituents-from-sophora-tonkinensis-and-their-glucose-transporter-4-translocation-activities
#9
Xinzhou Yang, Shihao Deng, Mi Huang, Jialin Wang, Li Chen, Mingrui Xiong, Jie Yang, Sijiang Zheng, Xinhua Ma, Ping Zhao, Yunjiang Feng
Bioassay-guided phytochemical investigation of the EtOAc fraction (ST-EtOAc) from the roots of Sophora tonkinensis resulted in the isolation of a new compound 6aR,11aR-1-hydroxy-4-isoprenyl-maackiain (1), along with 12 known compounds (2-13). The structure of the new compound was established by 1D and 2D NMR, MS data and circular dichroism analysis. Polyprenylated flavonoids 6-9 and 11-13 increased GLUT-4 translocation by the range of 1.35-2.75 folds. Sophoranone (8) exerted the strongest activity with 2.75 folds GLUT-4 translocation enhancement at the concentration of 10μM...
January 30, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28236460/phenolic-profiling-of-rooibos-using-off-line-comprehensive-normal-phase-countercurrent-chromatography%C3%A3-reversed-phase-liquid-chromatography
#10
Nico A Walters, André de Villiers, Elizabeth Joubert, Dalene de Beer
Limited performance of one dimensional chromatographic methods provides the incentive for the development of multidimensional chromatographic techniques for the analysis of complex mixtures. Rooibos (Aspalathus linearis) represents such a complex sample, containing a range of phenolic compounds that cannot be separated and identified using a single chromatographic technique within a reasonable run time. By implementing NP high performance countercurrent chromatography (NP-HPCCC) in the first dimension ((1)D) and RP ultra-high pressure LC (RP-UHPLC) in the second dimension ((2)D), a highly orthogonal (∼80%) off-line comprehensive two-dimensional separation of rooibos phenolic compounds was achieved in a total analysis time of 17h...
February 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28235721/characterization-and-structure-activity-relationship-of-natural-flavonoids-as-herg-k-channel-modulators
#11
Xiaorun Sun, Bingyuan Xu, Yucong Xue, Honglin Li, Huiran Zhang, Yuanyuan Zhang, Liying Kang, Xiaolu Zhang, Jianping Zhang, Zhanfeng Jia, Xuan Zhang
OBJECTIVES: Flavonoids are present in varying concentrations in plant foods and have been reported to have numerous pharmacological activities, such as anti-cancer, antioxidant, anti-inflammatory, hepatoprotective, and vasodilator effects. We found that quercetin, fisetin, and some related flavonoid derivatives could inhibit human ether-à-go-go-related gene (hERG) K(+) channels. KEY FINDINGS: In this study, we tested the effects of a series of flavonoids on the hERG K(+) channel expressed in HEK293 cells...
February 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28235660/targeting-the-tlr4-signaling-pathway-by-polyphenol-a-novel-therapeutic-strategy-for-neuroinflammation
#12
REVIEW
Mahban Rahimifard, Faheem Maqbool, Shermineh Moeini-Nodeh, Kamal Niaz, Mohammad Abdollahi, Nady Braidy, Seyed Mohammad Nabavi, Seyed Fazel Nabavi
A wide array of cell signaling mediators and their interactions play vital roles in neuroinflammation associated with ischemia, brain trauma, developmental disorders and age-related neurodegeneration. Along with neurons, microglia and astrocytes are also affected by the inflammatory cascade by releasing pro-inflammatory cytokines, chemokines and reactive oxygen species. The release of pro-inflammatory mediators in response to neural dysfunction may be helpful, neutral or even deleterious to normal cellular survival...
February 21, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28231543/date-seed-extract-ameliorates-%C3%AE-amyloid-induced-impairments-in-hippocampus-of-male-rats
#13
Farzaneh Dehghanian, Taj Pari Kalantaripour, Khadijeh Esmaeilpour, Leila Elyasi, Hakime Oloumi, Fatmeh Mehdi Pour, Majid Asadi-Shekaari
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder among the elderly. Because the existing treatments for Alzheimer's disease only offer limited symptomatic alleviation, more efficient therapeutic agents are urgently needed. Date seed is a hepatoprotective and neuroprotective agent. Date seed extract (DSE) has bioactive components like phenolics, flavonoids, and vitamins. In view of the ameliorative effects of DSE against an oxidative injury, the current study was designed to reveal whether DSE has a neuroprotective resource in the rat model of Alzheimer's disease...
February 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28231393/effects-of-tissue-culture-and-mycorrhiza-applications-in-organic-farming-on-concentrations-of-phytochemicals-and-antioxidant-capacities-in-ginger-zingiber-officinale-roscoe-rhizomes-and-leaves
#14
Byungrok R Min, Lurline E Marsh, Keegan Brathwaite, Adebola O Daramola
Tissue culture and mycorrhiza applications can provide disease-free seedlings and enhanced nutrient absorption, respectively, for organic farming. Ginger (Zingiber officinale Roscoe) is rich in phytochemicals and has various health-protective potentials. This study was aimed at determining effects of tissue culture and mycorrhiza applications alone or in combinations in organic farming on phytochemical contents (total phenolics and flavonoids [TP and TF, respectively], gingerol and shogaol homologues, phenolic acids, and carotenoids) and antioxidant capacities (DPPH [2,2-diphenyl-1-picrylhydrazyl] radical scavenging, oxygen radical absorbance (ORAC), and iron-chelating capacities [ICC]) in solvent-extractable (Free) and cell-wall-matrix-bound (Bound) fractions of ginger rhizome and Free fraction of the leaves in comparison with non-organics...
February 23, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28231262/oleanolic-acid-induces-migration-in-mv1lu-and-mda-mb-231-epithelial-cells-involving-egf-receptor-and-map-kinases-activation
#15
Ángel Bernabé-García, David Armero-Barranco, Sergio Liarte, María Ruzafa-Martínez, Antonio Jesús Ramos-Morcillo, Francisco José Nicolás
During wound healing, skin function is restored by the action of several cell types that undergo differentiation, migration, proliferation and/or apoptosis. These dynamics are tightly regulated by the evolution of the extra cellular matrix (ECM) contents along the process. Pharmacologically active flavonoids have shown to exhibit useful physiological properties interesting in pathological states. Among them, oleanolic acid (OA), a pentacyclic triterpene, shows promising properties over wound healing, as increased cell migration in vitro and improved wound resolution in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28231170/fermentation-assisted-extraction-of-isothiocyanates-from-brassica-vegetable-using-box-behnken-experimental-design
#16
Amit K Jaiswal, Nissreen Abu-Ghannam
Recent studies showed that Brassica vegetables are rich in numerous health-promoting compounds such as carotenoids, polyphenols, flavonoids, and glucosinolates (GLS), as well as isothiocyanates (ITCs) and are involved in health promotion upon consumption. ITCs are breakdown products of GLS, and typically used in the food industry as a food preservative and colouring agent. They are also used in the pharmaceutical industry due to their several pharmacological properties such as antibacterial, antifungal, antiprotozoal, anti-inflammatory, and chemoprotective effects, etc...
November 4, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231150/enhancing-the-total-phenolic-content-and-antioxidants-of-lemon-pomace-aqueous-extracts-by-applying-uv-c-irradiation-to-the-dried-powder
#17
Konstantinos Papoutsis, Quan V Vuong, Penta Pristijono, John B Golding, Michael C Bowyer, Christopher J Scarlett, Costas E Stathopoulos
Several studies have shown that UV-C (ultraviolet C) irradiation promotes the bioactive compounds and antioxidants of fresh fruits and vegetables. The aim of this study was to apply UV irradiation in dried lemon pomace powder for enhancing its phenolic content and antioxidant properties, thus more bioactive compounds should be available for extraction and utilization. Lemon pomace dried powder was placed under a UV lamp and treated with dosages of 4, 19, 80 and 185 kJ·m(-2), while untreated powder was used as a control...
August 23, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231132/preparation-of-a-breadfruit-flour-bar
#18
Carmen L Nochera, Diane Ragone
Breadfruit is a nutritious, high energy food with a low quantity of protein but excellent protein quality. It has the potential to be developed into desired products which will help increase its utilization and add value to the crop. The overall purposes of this investigation were to develop a portable, nutritious, ready-to-eat breadfruit product (bar), test the sensory qualities of the product, and evaluate the nutritional properties of the product. Flour made from the Micronesian variety, Meinpadahk (Artocarpus altilis × Artocarpus mariannensis), was utilized for the development of the breadfruit bar...
May 20, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231051/short-communication-challenges-relating-to-comparison-of-flavonoid-glycosides-dissolution-profiles-from-sutherlandia-frutescens-products
#19
Oluchi N Mbamalu, James Syce, Halima Samsodien
Unlike the case of conventional drug formulations, dissolution tests have hitherto not been required for herbal medicinal products commercially available in South Africa. This study investigated dissolution of the South African Sutherlandia frutescens using selected flavonoid glycosides as marker compounds. Dissolution of markers was assessed in three dissolution media at pH 1.2, 4.5 and 6.8, and samples were analysed using a validated HPLC method. The dissolution profile of each marker varied for the different materials investigated...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28230797/zyz-772-prevents-cardiomyocyte-injury-by-suppressing-nox4-derived-ros-production-and-apoptosis
#20
Ying Wang, Liangjie Zhong, Xinhua Liu, Yi Zhun Zhu
Nox-dependent signaling plays critical roles in the development of heart failure, cardiac hypertrophy, and myocardial infarction. NADPH oxidase 4 (Nox4) as a major source of oxidative stress in the heart offers a new therapeutic target in cardiovascular disease. In the present work, a novel flavonoid was isolated from Zanthoxylum bungeanum. Its structure was elucidated as Quercetin-3-O-(6''-O-α-l-rhamnopyransoyl)-β-d-glucopyranoside-7-O-β-d-glucopyranoside (ZYZ-772) for the first time. ZYZ-772 exhibited significant cardio-protective property against CoCl₂ induced H9c2 cardiomyocyte cells injury...
February 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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