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https://www.readbyqxmd.com/read/29031211/cyanidin-3-o-glucoside-inhibits-the-uvb-induced-ros-cox-2-pathway-in-hacat-cells
#1
Yong He, Yunfeng Hu, Xinwei Jiang, Tianfeng Chen, Yuetang Ma, Shi Wu, Jianxia Sun, Rui Jiao, Xiaoling Li, Liehua Deng, Weibin Bai
Ultraviolet (UV) radiation from sunlight, especially UVB (290-320nm), is one of the most important environmental factors that destroys the integrity of the skin and causes epidermal cell apoptosis, potentially even leading to skin cancer. UVB irradiation can cause skin damage by stimulating inflammatory and apoptotic pathways. Anthocyanins are flavonoids that are common in many vegetable foods, and have also demonstrated chemopreventive effects. Cyanidin-3-O-glucoside, as a typical anthocyanin, exhibits anti-inflammatory and anti-oxidant effects...
October 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29028587/chemical-constituents-and-medical-benefits-of-plantago-major
#2
REVIEW
Muhammad Bahrain Adom, Muhammad Taher, Muhammad Fathiy Mutalabisin, Mohamad Shahreen Amri, Muhammad Badri Abdul Kudos, Mohd Wan Azizi Wan Sulaiman, Pinaki Sengupta, Deny Susanti
The medicinal benefits of Plantago major have been acknowledged around the world for hundreds of years. This plant contains a number of effective chemical constituents including flavonoids, alkaloids, terpenoids, phenolic acid derivatives, iridoid glycosides, fatty acids, polysaccharides and vitamins which contribute to its exerting specific therapeutic effects. Correspondingly, studies have found that Plantago major is effective as a wound healer, as well as an antiulcerative, antidiabetic, antidiarrhoeal, anti-inflammatory, antinociceptive, antibacterial, and antiviral agent...
October 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29028495/non-cytotoxic-effect-of-green-synthesized-silver-nanoparticles-and-its-antibacterial-activity
#3
B Senthil, T Devasena, B Prakash, A Rajasekar
Silver nanoparticles (AgNPs) were green synthesized using ethanolic extract of fenugreek leaves and characterized using UV-Vis spectroscopy, Fourier transform infra-red spectroscopy (FTIR), X-ray diffraction (XRD), high resolution transmission electron microscopy HRTEM and energy dispersive X-ray analysis (EDX) techniques. The HRTEM results revealed the formation of highly stable, mono dispersed, spherical shaped AgNPs with the size ranging from 20 to 30nm. The presence of flavonoids and their interaction with the AgNPs were confirmed using FTIR...
October 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29027933/dpph-radical-scavenging-and-postprandial-hyperglycemia-inhibition-activities-and-flavonoid-composition-analysis-of-hawk-tea-by-uplc-dad-and-uplc-q-tof-ms-e
#4
Xuan Xiao, Lijia Xu, Huagang Hu, Yinjun Yang, Xinyao Zhang, Yong Peng, Peigen Xiao
Hawk tea (Litsea coreana Lévl. var. Lanuginosa (Migo) Yen C. Yang & P.H. Huang), a very popular herbal tea material, has attracted more and more attention due to its high antioxidant properties and possible therapeutic effect on type II diabetes mellitus. The raw materials of Hawk tea are usually divided into three kinds: bud tea (BT), primary leaf tea (PLT) and mature leaf tea (MLT). In this study, the DPPH radical scavenging activity and the antimicrobial properties of these three kinds of Hawk tea from different regions were comparatively investigated, and a ultra-high performance liquid chromatographic coupled with a photodiode array detector (UPLC-DAD) method was employed for comparison of the three major flavonoid constituents, including hyperoside, isoquercitrin and astragalin, in different samples of Hawk tea...
October 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29027704/effect-of-royal-jelly-on-behavioural-patterns-feather-quality-egg-quality-and-some-haematological-parameters-in-laying-hens-at-the-late-stage-of-production
#5
M S El-Tarabany
The aim was to elucidate the impact of Royal Jelly (RJ) on behavioural patterns, feather cover, egg quality and some blood haematological indices in laying hens (58-64 weeks of age). A total of 108 Tetra Brown laying hens were used in the current trial. The birds were divided into three equal groups (36 birds each). The pure RJ was prepared for immediate injection subcutaneously, as follows: the first treated group (RJ1 :100 mg/kg); the second treated group (RJ2 :200 mg/kg); the control group. The eating and drinking activities in the RJ2 group were significantly (p = ...
October 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29027430/-virtual-screening-of-anti-angiogenesis-flavonoids-from-sophora-flavescens
#6
Xi-Xin Chen, Yi Liu, Rong Huang, Lin-Lin Zhao, Lei Chen, Shu-Mei Wang
Angiogenesis is a dynamic, multi-step process. It is known that about 70 diseases are related to angiogenesis. Both the experimental and the literature reports showed that Sophora flavescens inhibit angiogenesis significantly, but the material basis and the mechanism of action have not been clear. In this study, molecular docking was used for screening of anti-angiogenesis flavonoids from the roots of S. flavescens. One handred and twenty-six flavonoids selected from S. flavescens were screened in the docking ligand database with six targets(VEGF-a,TEK,KDR,Flt1,FGFR1 and FGFR2) as the receptors...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29026903/the-effect-of-cognitive-demand-on-performance-of-an-executive-function-task-following-wild-blueberry-supplementation-in-7-to-10-years-old-children
#7
A R Whyte, G Schafer, C M Williams
The cognitive benefits of acute flavonoid interventions have been well documented, however, research to date has found that, depending on developmental stage, these benefits manifest themselves in different cognitive domains. It is argued that the lack of global cognitive effects following flavonoid intervention may be a result of insufficient task sensitivity for those domains where no benefits are found. In children, executive function is a cognitive domain which has shown little apparent benefit following flavonoid intervention...
October 13, 2017: Food & Function
https://www.readbyqxmd.com/read/29025433/the-role-of-the-glycosyl-moiety-of-myricetin-derivatives-in-anti-hiv-1-activity-in-vitro
#8
Joseph T Ortega, Alirica I Suárez, Maria L Serrano, Jani Baptista, Flor H Pujol, Hector R Rangel
BACKGROUND: Plant extracts are sources of valuable compounds with biological activity, especially for the anti-proliferative activity against pathogens or tumor cells. Myricetin is a flavonoid found in several plants that has been described as an inhibitor of Human immunodeficiency virus type 1 (HIV-1) through its action against the HIV reverse transcriptase, but myricetin derivatives have not been fully studied. The aim of this study was to evaluate the anti-HIV-1 activity of glycosylated metabolites obtained from Marcetia taxifolia and derived from myricetin: myricetin rhamnoside and myricetin 3-(6-rhamnosylgalactoside)...
October 12, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/29025321/rutin-ameliorates-oxidative-stress-and-preserves-hepatic-and-renal-functions-following-exposure-to-cadmium-and-ethanol
#9
Sunny O Abarikwu, Rex-Clovis Njoku, Chiamaka J Lawrence, Iniobong A Charles, Jude C Ikewuchi
CONTEXT: Rutin (RUT) is an antioxidant flavonoid with well-known metal chelating potentials. OBJECTIVE: This study was designed to evaluate the protective effects of RUT against cadmium (Cd) + ethanol (EtOH)-induced hepatic and renal toxicity in rats. MATERIALS AND METHODS: Wistar rats were treated with Cd (50 mg/kg) alone or in combination with EtOH (5 mg/kg) and RUT (25, 50 and 100 mg/kg) for 15 days. After treatment, the liver, kidney and serum were removed for biochemical assays by spectrophotometric methods...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29024631/luteoloside-induces-g0-g1-arrest-and-pro-death-autophagy-through-the-ros-mediated-akt-mtor-p70s6k-signalling-pathway-in-human-non-small-cell-lung-cancer-cell-lines
#10
Menglu Zhou, Shuying Shen, Xin Zhao, Xingguo Gong
Autophagy has attracted a great deal of interest in tumour therapy research in recent years. However, the anticancer effect of luteoloside, a naturally occurring flavonoid isolated from the medicinal plant Gentiana macrophylla, on autophagy remains poorly understood in human lung cells. In the present study, we have investigated the anticancer effects of luteoloside on non-small cell lung cancer (NSCLC) cells and demonstrated that luteoloside effectively inhibited cancer cell proliferation, inducing G0/G1phase arrest associated with reduced expression of CyclinE, CyclinD1 and CDK4; we further found that treatment with luteoloside did not strongly result in apoptotic cell death in NSCLC (A549 and H292) cells...
October 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29023845/aqueous-extract-of-gynura-bicolor-attenuated-hepatic-steatosis-glycative-oxidative-and-inflammatory-injury-induced-by-chronic-ethanol-consumption-in-mice
#11
Mei-Chin Yin, Zhi-Hong Wang, Wen-Hu Liu, Mei-Chin Mong
Gynura bicolor leaf aqueous extract (GAE) is rich in phytochemicals including phenolic acids, flavonoids, carotenoids, and anthocyanins. Effects of GAE upon hepatic injury in mice with chronic ethanol intake were examined. Lieber-DeCarli liquid diet with ethanol was used to induce hepatic lipid accumulation, oxidative, glycative, and inflammatory injury. GAE at 0.25% or 0.5% was added in feeds, and supplied to mice consumed Lieber-DeCarli liquid diet with ethanol for 6 wk. Blood and liver were collected for analyses...
October 12, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29023716/production-of-cornstarch-granules-enriched-with-quercetin-liposomes-by-aggregation-of-particulate-binary-mixtures-using-high-shear-process
#12
Taíse Toniazzo, Helena Galeskas, Gustavo C Dacanal, Samantha C Pinho
Liposomes are colloidal structures capable of encapsulating, protecting, and releasing hydrophobic bioctives, as flavonoids. Quercetin is a flavonoid with high antioxidant activity that provides benefits to health. The wet-agglomeration processes in high-shear equipment are useful to produce granules from binary mixtures, obtaining a powder with homogeneous composition and without segregation or elutriation of fine particles. In this study, the binary mixtures containing microparticles of native cornstarch and nanoparticles of quercetin liposomes were aggregated in high-shear batches, using maltodextrin solution as binder agent...
October 12, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29023401/effects-of-sorghum-malting-on-colour-major-classes-of-phenolics-and-individual-anthocyanins
#13
Ali Khoddami, Mohammad Mohammadrezaei, Thomas H Roberts
Sorghum (Sorghum bicolor) grain contains many health-promoting phytochemicals, including a broad range of phenolic compounds. Malting of cereal grains is known to increase the bioavailability of macro- and micronutrients. However, the detailed effects of malting on sorghum grain anthocyanins, a major class of phenolics that influence the taste and colour of sorghum-based foods, requires further investigation. Eight commercial sorghum hybrids harvested from three regions in eastern Australia were malted and analysed for colour, tannin content, total phenolic content (TPC), flavan-4-ols, total flavonoids, total anthocyanins and 3-deoxyanthocyanins...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29023372/parp-inhibition-by-flavonoids-induced-selective-cell-killing-to-brca2-deficient-cells
#14
Cathy Su, Alexis H Haskins, Chisato Omata, Yasushi Aizawa, Takamitsu A Kato
High consumption of dietary flavonoids might contribute to a reduction of cancer risks. Quercetin and its glycosides have PARP inhibitory effects and can induce selective cytotoxicity in BRCA2-deficient cells by synthetic lethality. We hypothesized that common flavonoids in diet naringenin, hesperetin and their glycosides have a similar structure to quercetin, which might have comparable PARP inhibitory effects, and can induce selective cytotoxicity in BRCA2-deficient cells. We utilized Chinese hamster V79 wild type, V-C8 BRCA2-deficient and its gene-complemented cells...
October 12, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29023367/effect-of-cadmium-and-copper-exposure-on-growth-secondary-metabolites-and-antioxidant-activity-in-the-medicinal-plant-sambung-nyawa-gynura-procumbens-lour-merr
#15
Mohd Hafiz Ibrahim, Yap Chee Kong, Nurul Amalina Mohd Zain
A randomized complete block (RCBD) study was designed to investigate the effects of cadmium (Cd) and copper (Cu) on the growth, bioaccumulation of the two heavy metals, metabolite content and antibacterial activities in Gyanura procumbens (Lour.) Merr. Nine treatments including (1) control (no Cd and Cu); (2) Cd 2 = cadmium 2 mg/L; (3) Cd 4 = cadmium 4 mg/L; (4) Cu 70 = copper 70 mg/L; (5) Cu 140 = copper 140 mg/L); (6) Cd 2 + Cu 70 = cadmium 2 mg/L + copper 70 mg/L); (7) Cd 2 + Cu 140 = cadmium 2 mg/L + copper 70 mg/L); (8) Cd 4 + Cu 70 = cadmium 4 mg/L+ copper 70 mg/L and (9) Cd 4 + Cu 140 = cadmium 4 mg/L + copper 140 mg/L) were evaluated in this experiment...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29023076/flavonoid-production-growth-and-differentiation-of-stelechocarpus-burahol-bl-hook-f-and-th-cell-suspension-culture
#16
Noor Aini Habibah, Sukarti Moeljopawiro, Kumala Dewi, Ari Indrianto
BACKGROUND AND OBJECTIVE: Stelechocarpus burahol is a plant containing flavonoid compounds that have the potential for use as an antihyperuricemic for gout medication. This study was performed to assess flavonoid production, growth and cell differentiation of S. burahol in cell suspension culture. METHODOLOGY: Mesocarp was planted in Murashige and Skoog (MS) medium supplemented with 7.5 mg L-1 picloram for the induction of callus. Non-embryonic callus obtained was used in the formation of cell suspension cultures...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29023064/impact-of-zeatin-and-thidiazuron-on-phenols-and-flavonoids-accumulation-in-callus-cultures-of-gardenia-gardenia-jasminoides
#17
Ahmed Mohamed Magdy Gabr, Nermeen Mohamed Arafa, Amal Abd El-Latif El-Ashry, Mohamed Kamal El-Bahr
BACKGROUND AND OBJECTIVE: Gardenia (Gardenia jasminoides) has many pharmacological actions such as anti-inflammatory, antioxidant and fibrolytic activities and cytotoxic effects, etc. This study was conducted to recognize the effect of zeatin and thidiazuron (TDZ) on callus proliferation, total phenolic content, total flavonoids and DPPH scavenging activity of gardenia callus cultures. MATERIALS AND METHODS: Calli were cultured on Murashige and Skoog (MS) medium supplement with different concentrations (2, 4 or 6 mg L-1) of zeatin or TDZ individually as well as combination of 2 mg L-1 zeatin+4 mg L-1 TDZ...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022496/antitumor-and-radiosensitizing-synergistic-effects-of-apigenin-and-cryptotanshinone-against-solid-ehrlich-carcinoma-in-female-mice
#18
Amina M Medhat, Khaled Sh Azab, Mahmoud M Said, Neama M El Fatih, Nermeen M El Bakary
Considerable attention has been paid to the introduction of novel naturally occurring plant-derived radiosensitizer compounds in order to augment the radiation efficacy and improve the treatment outcome of different tumors. This study was therefore undertaken to evaluate the antitumor, antiangiogeneic, and synergistic radiosensitizing effects of apigenin, a dietary flavonoid, and/or cryptotanshinone, a terpenoid isolated from the roots of Salvia miltiorrhiza, against the growth of solid Ehrlich carcinoma in female mice...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29022361/interactions-of-quercetin-with-receptor-tyrosine-kinases-associated-with-human-lung-carcinoma
#19
Bincy Baby, Priya Antony, Ranjit Vijayan
Lung cancer is a deadly form of cancer with high morbidity and mortality rates. Deregulated receptor tyrosine kinases (RTKs) are frequently associated with the formation and development of lung carcinoma. Quercetin is a major dietary flavonoid that has been shown to induce cell growth inhibition and apoptosis in human lung cancer cell lines. In the current study, four major overexpressed RTKs - EGFR, FGFR1, IGF1R and c-Met - involved in human lung cancer were investigated. Molecular docking was employed to identify the binding orientation and inhibitory potential of quercetin in these RTKs...
October 12, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29021760/saponins-and-flavonoids-from-adzuki-bean-vigna-angularis-l-ameliorate-high-fat-diet-induced-obesity-in-icr-mice
#20
Rui Liu, Yinan Zheng, Zongwei Cai, Baojun Xu
Background and purpose: As an herbal medicine, adzuki bean has been practiced since the Tang Dynasty of China to maintain health and control weight; this practice is still very popular in China nowadays. However, it is still lack of sufficient scientific basis to explain scientific principle of this popular civil practice in weight control using adzuki bean. The purpose of this study was to verify and explain the anti-obesity effects of adzuki bean through in vitro enzymatic assays, in vitro lipolysis and in vivo study of obese mice model...
2017: Frontiers in Pharmacology
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