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https://www.readbyqxmd.com/read/27935362/dramatic-radiographic-response-resulting-in-cerebrospinal-fluid-rhinorrhea-associated-with-sunitinib-therapy-in-recurrent-atypical-meningioma-case-report
#1
Amol Raheja, Howard Colman, Cheryl A Palmer, William T Couldwell
Sunitinib is a multiple tyrosine kinase inhibitor with antiangiogenic, cytostatic, and antimigratory activity for meningiomas. A recent clinical trial of sunitinib for treatment of recurrent Grade II and III meningiomas suggested potential efficacy in this population, but only 2 patients exhibited significant radiographic response with tumor volume reduction. The authors illustrate another such case and discuss a complication related to this dramatic tumor volume reduction in aggressive skull base meningiomas...
December 9, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27932168/spindle-cell-lipoma-in-an-end-stage-renal-allograft-case-report
#2
Z Zhao, S Selvarajan, A L S Tiong, T H Lim, L Y Khor
BACKGROUND: Spindle cell lipoma is an uncommon variant of lipoma and usually occurs as a solitary, subcutaneous, and well circumscribed lesion in the posterior neck, shoulders, and back of older men. Primary renal lipomas are rarely reported. Spindle cell lipoma in the kidney has not been previously described in the literature. CASE REPORT: A 60-year-old Chinese man suffered graft failure 10 years after living related donor kidney transplantation. During cancer surveillance, he was found to have a mass in the renal allograft, which increased in size and was suspicious for renal cell carcinoma on computerized tomographic scan...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27927612/assessment-of-the-cancer-risk-of-the-fat-grafted-breast-in-a-murine-model
#3
Francisco Claro, Luciana R Moreira, Joseane Morari, Luis O Z Sarian, Glauce A Pinto, Licio A Velloso, Aarão M Pinto-Neto
BACKGROUND: The results of experimental studies indicate that grafting of autologous adipose tissue may induce tumorigenesis at the recipient site, but clinical results do not support a carcinogenic effect of fat grafting to the breast. OBJECTIVES: The authors assessed cancer risk following transplantation of autologous fat into murine mammary tissue. METHODS: In this animal study, mammary tissues from 54 breasts of 9 female rats were either grafted with autologous subcutaneous fat, grafted with autologous omental fat, or unmanipulated...
December 7, 2016: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/27924172/hyaluronic-acid-fat-graft-myringoplasty-versus-autologous-platelet-rich-plasma
#4
Salman F Alhabib, Issam Saliba
BACKGROUND: Hyaluronic acid fat graft myringoplasty (HAFGM) is an office-based technique for tympanic membrane perforation (TMP) treatment. It is simple, inexpensive, and performed under local anesthesia at the outpatient office department. We aimed to compare HAFGM technique to a recently described topical use of autologous platelet rich plasma myringoplasty (PRPM) in the repair of TMP. We also aimed to assess the hearing level improvement postoperatively. METHODS: We conducted a prospective study in an adult tertiary care center between January 2015 and January 2016...
January 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27922487/breast-augmentation-combining-fat-injection-and-breast-implants-in-patients-with-atrophied-breasts
#5
Burhan Özalp, Mustafa Aydinol
Breast augmentation is a challenging issue in atrophied breasts related to breastfeeding. Here, we describe a modification combining breast implants and fat grafting to obtain a successful outcome without implant edge visibility and palpability.Thirty-four women with atrophied breasts underwent breast augmentation over a 6-year period. The breast implants were placed in the subglandular plane to obtain optimal filling and expansion of atrophied breast tissue. Autologous fat grafting was performed above the inframammary sulcus to prevent implant visibility and palpability due to insufficient soft tissue coverage...
December 2, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27921032/the-collection-of-adipose-derived-stem-cells-using-water-jet-assisted-lipoplasty-for-their-use-in-plastic-and-reconstructive-surgery-a-preliminary-study
#6
Valeria Purpura, Elena Bondioli, Davide Melandri, Pier C Parodi, Luca Valenti, Michele Riccio
The graft of autologous fat for the augmentation of soft tissue is a common practice frequently used in the field of plastic and reconstructive surgery. In addition, the presence of adipose derived stem cells (ASCs) in adipose tissue stimulates the regeneration of tissue in which it is applied after the autologous fat grafting improving the final clinical results. Due to these characteristics, there is an increasing interest in the use of ASCs for the treatment of several clinical conditions. As a consequence, the use of clean room environment is required for the production of cell-based therapies...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27919352/impact-of-a-1-year-lifestyle-modification-program-on-plasma-lipoprotein-and-pcsk9-concentrations-in-patients-with-coronary-artery-disease
#7
Marjorie Boyer, Valérie Lévesque, Paul Poirier, André Marette, Patrick Mathieu, Jean-Pierre Després, Éric Larose, Benoit J Arsenault
BACKGROUND: Patients with coronary artery disease (CAD) are characterized by an impaired cardiometabolic risk profile including high levels of atherogenic apolipoprotein (apo) B-containing lipoprotein levels. Genetic studies have highlighted a critical role for proprotein convertase subtilisin/kexin type 9 (PCSK9) in lipoprotein metabolism and CAD risk. OBJECTIVE: To determine whether improving dietary quality and increasing physical activity levels improve parameters of the cardiometabolic risk profile such as plasma apoB and PCSK9 levels in patients with CAD...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27916399/fat-grafting-is-a-feasible-technique-for-the-sequelae-of-head-and-neck-cancer-treatment
#8
J Gutiérrez Santamaría, J Masiá Gridilla, J Pamias Romero, J Giralt López-de-Sagredo, M S Bescós Atín
OBJECTIVE: The fatty tissue regenerative properties have already been used to correct secondary scars (mastectomy, HIV lipodystrophy), resulting in improved elasticity and tissue quality. However there has been limited experience in treating the sequela of head and neck cancer treatment using fat tissue grafting. The objective of this study was to perform a preliminary evaluation of the injection of autologous fat (IAF) technique, for the sequelae treatment in head and neck cancer patients...
November 1, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27915440/liver-steatosis-in-pre-transplant-liver-biopsies-can-be-quantified-rapidly-and-accurately-by-nuclear-magnetic-resonance-analysis
#9
Stefanie Bertram, Cathrin Myland, Sandra Swoboda, Anja Gallinat, Thomas Minor, Nils Lehmann, Michael Thie, Julia Kälsch, Leona Pott, Ali Canbay, Thomas Bajanowski, Henning Reis, Andreas Paul, Hideo A Baba
Donor livers marginally acceptable or acceptable according to extended criteria are more frequently transplanted due to the growing discrepancy between demand and availability of donor organs. One type of marginally acceptable graft is a steatotic donor liver, because it is more sensitive to ischemia-reperfusion injury. Thus, quantitative assessment of steatosis is crucial prior to liver transplantation. Extent of steatosis of 49 pre-reperfusion liver biopsies from patients who received orthotopic liver transplantation was assessed by three techniques: semi-quantitative histological evaluation, computerized histomorphometry, and NMR-based estimation of fat content...
December 3, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27914123/extending-the-indications-for-autologous-breast-reconstruction-using-a-two-stage-modified-goldilocks-procedure-a-case-report
#10
Jean-Claude D Schwartz, Piotr P Skowronksi
Post-mastectomy reconstruction is performed using implant-based or autologous techniques. Many women refuse or are poor candidates for implant-based reconstruction. We previously described a single-stage autologous technique that was most applicable in obese women with significant ptosis that made use of the mastectomy skin flap and subcutaneous tissue to reconstruct a breast mound. Here, we extend this technique to smaller breasted women by incorporating a second stage of skin tailoring and fat grafting. This technique does not require donor site surgery nor extended operative and recovery times...
December 3, 2016: Breast Journal
https://www.readbyqxmd.com/read/27896423/long-term-outcomes-following%C3%A2-h-type-tracheoesophageal-fistula%C3%A2-repair-in-infants
#11
Augusto Zani, Luai Jamal, Giovanni Cobellis, Justyna M Wolinska, Samuel Fung, Evan J Propst, Priscilla P L Chiu, Agostino Pierro
PURPOSE: To evaluate outcomes following repair of H-type tracheoesophageal fistula (TEF). METHODS: Retrospective chart review of infants with H-type TEF treated at our institution between 2000 and 2014. Patient demographics, surgical management, and postoperative function were evaluated. RESULTS: Of the 268 patients with esophageal atresia/TEF treated at our center, 16 (6%) had an H-type TEF (10 males). Thirteen (81%) had associated anomalies...
November 28, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27894610/-reconstruction-of-proximal-nasal-defect-after-deep-carcinological-resection-interest-to-combine-titane-mesh-with-fat-grafting
#12
R Aimard, C Lalloué, C Ho Quoc, D Girodet, P Zrounba, E Delay
INTRODUCTION: The mucosal cylindroma or adenoid cystic carcinoma is the second sinonasal non-epithelial malignant tumor frequency argument. Due to the achievement of the nasal mucosa and a late diagnosis reconstructions are often complex. We report the case of a mucous cylindroma recurrence of nasal septum requiring a wide and deep excision of the root of the nose with nasal reconstruction. CASE REPORT: A patient aged 66 years whose history resection two years ago with a mucous adenoid cystic carcinoma of the right side of the nasal septum, had a local recurrence T2NOM0 imposing a wide excision with amputation nasal septum own bones of nose, the anterior portion of the triangular cartilages...
November 25, 2016: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/27893636/facial-contouring-by-targeted-restoration-of-facial-fat-compartment-volume-the-mid-face
#13
Wenjin Wang, Yun Xie, Ru-Lin Huang, Jia Zhou, Herrler Tanja, Peijuan Zhao, Chen Cheng, Sizheng Zhou, Lee L Q Pu, Qingfeng Li
BACKGROUND: Recent anatomical findings have suggested that facial fat distribution is complex and changes with age. Here, we developed a grafting technique based on the physiological distribution and volume changes of facial fat compartments to achieve a youthful and natural-looking face. METHODS: Forty cadaveric hemifaces were used for the dissection of fat compartments and neurovascular structures in the mid-face area. Seventy-eight patients were treated for cheek atrophy using our targeted restoration of mid-face fat compartment volume...
November 21, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27893630/a-comprehensive-in-vitro-comparison-of-preparation-techniques-for-fat-grafting
#14
Libor Streit, Josef Jaros, Veronika Sedlakova, Miroslava Sedlackova, Lubos Drazan, Michal Svoboda, Jakub Pospisil, Tomas Vyska, Jiri Vesely, Ales Hampl
BACKGROUND: Lipomodelling is a technique that uses patient's own fat for tissue regeneration and augmentation. The extent of regenerative effect is reported to be determined by the numbers of adipose tissue-derived stem cells (ASCs) and the viability of cells in processed adipose tissue, which, together with other factors, influence the degree of graft retention. This study addresses whether differences exist in properties of fat graft obtained by three commonly used techniques. METHODS: Adipose tissue harvested from the hypo-gastric regions of 14 patients was processed by decantation, centrifugation, and membrane-based tissue filtration...
November 21, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27893580/the-effects-of-adipose-derived-stem-cell-differentiated-adipocytes-on-skin-burn-wound-healing-in-rats
#15
Yu-Wen Chen, Tabita Timeea Scutaru, Nicolae Ghetu, Eugen Carasevici, Cristian Dumitru Lupascu, Dan Ferariu, Dragos Pieptu, Corneliu-George Coman, Mihai Danciu
Both adipose-derived stem cells (ADSCs) and fat grafting promote burn wound healing, but whether adipogen-derived cells using various inducers such as 3-isobutyl-1-methylxanthine (IBMX) and insulin affect wound healing is unknown. Herein, ADSC-differentiated adipogenic lineages were used in rat burn wounds to evaluate wound healing potential. ADSCs were cultivated using six different adipogenic differentiation conditions (IBMX ± insulin, IBMX for 5 days, high and low Dulbecco's modified Eagle's medium) and in vitro morphological changes and cell proliferations during adipogenic differentiation were recorded...
November 11, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27887867/evaluation-of-function-and-recovery-of-adipose-derived-stem-cells-after-exposure-to-paclitaxel
#16
William M Harris, Ping Zhang, Michael Plastini, Telisha Ortiz, Nikolas Kappy, Jefferson Benites, Edward Alexeev, Shaohua Chang, Ross Brockunier, Jeffrey P Carpenter, Spencer A Brown
BACKGROUND AIMS: Adipose-derived stem cells (ASCs) are considered to play a positive role in wound healing as evidenced by their increasing use in breast reconstructive procedures. After chemotherapy for breast cancer, poor soft tissue wound healing is a major problem. In the present study, the functional capabilities and recovery of ASCs after exposure to chemotherapeutic agent paclitaxel (PTX) using in vitro and ex vivo models were demonstrated. METHODS: Human ASCs were isolated from periumbilical fat tissue and treated with PTX at various concentrations...
November 22, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27883321/body-size-and-outcomes-in-dialysis-and-transplant-patients-does-it-matter
#17
Mehmet Sukru Sever
The terminologies of "body size", "body mass index (BMI)", "body weight", "large BMI" and "obesity" are controversial for defining the effects of "adiposity" or "fat excess" on the outcomes of dialysis and transplant patients. However, probably these terminologies will be continued to be used in the future as well, because of being older and simpler terminologies. In the general population obesity is a powerful risk factor for cardiovascular morbidity and mortality, while, it conferred a survival advantage to dialysis patients...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27872327/relation-between-cardiovascular-disease-risk-factors-and-epicardial-adipose-tissue-density-on-cardiac-computed-tomography-in-patients-at-high-risk-of-cardiovascular-events
#18
Bas T Franssens, Hendrik M Nathoe, Tim Leiner, Yolanda van der Graaf, Frank Lj Visseren
BACKGROUND: The radiodensity of epicardial adipose tissue may provide information on cardiovascular risk in addition to epicardial adipose tissue volume. The aim of this study was to quantify the relation between cardiovascular risk factors and the radiodensity of epicardial adipose tissue in patients at high risk of cardiovascular disease. DESIGN: This was a cross-sectional study in 140 patients at high risk of cardiovascular disease. METHODS: Patients from the Secondary Manifestations of ARTerial disease (SMART) cohort study were invited to undergo cardiac computed tomography angiography...
November 21, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27860296/impact-of-subnormothermic-machine-perfusion-preservation-in-severely-steatotic-rat-livers-a-detailed-assessment-in-an-isolated-setting
#19
Y Okamura, K Hata, H Tanaka, H Hirao, T Kubota, O Inamoto, S Kageyama, I Tamaki, N Yermek, J Yoshikawa, S Uemoto
Current drastic shortage of donor organs has led to acceptance of extended-criteria donors for transplantation, despite higher risk of primary non-function. Here, we report the impact of subnormothermic machine perfusion (SMP) preservation on the protection of >50% macro-steatotic livers. Dietary hepatic steatosis was induced in Wistar rats via 2-day fasting and subsequent 3-day re-feeding with a fat-free, carbohydrate-rich diet. This protocol induces 50-60% macrovesicular steatosis, which should be discarded when preserved via cold storage (CS)...
November 10, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27853678/rejuvenation-of-facial-skin-and-improvement-in-the-dermal-architecture-by-transplantation-of-autologous-stromal-vascular-fraction-a-clinical-study
#20
Mohammad Amir Amirkhani, Alireza Shoae-Hassani, Masoud Soleimani, Somayeh Hejazi, Leila Ghalichi, Mohammad Ali Nilforoushzadeh
Introduction: The rejuvenation characteristics of fat tissue grafting has been established for many years. Recently it has been shown that stromal vascular fraction (SVF) of fat tissue contributes to its rejuvenation properties. As the SVF is a minimal processed cell population (based on FDA guidance), therefore it is a suitable cell therapy for skin rejuvenation. This clinical trial was aimed to evaluate the ultrastructural improvement of aging skin in the facial nasolabial region after transplantation of autologous SVF...
2016: BioImpacts: BI
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