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https://www.readbyqxmd.com/read/28102614/expression-of-cd4-cd28-null-t-lymphocytes-in-children-and-adolescents-with-type-1-diabetes-mellitus-relation-to-microvascular-complications-aortic-elastic-properties-and-carotid-intima-media-thickness
#1
Mona H El-Samahy, Azza A G Tantawy, Amira A M Adly, Nevin M Habeeb, Eman A R Ismail, Gehan M Hamed, Rasha Eladawy
BACKGROUND: Cardiovascular risk in type 1 diabetes mellitus (T1DM) is associated with endothelial dysfunction, inflammation, and altered immunity. CD4(+) CD28(null) T-cells are a subset of long-lived cytotoxic CD4(+) T-lymphocytes with proatherogenic and plaque-destabilizing properties. We hypothesized that the frequency of CD4(+) CD28(null) T-cells may be altered in T1DM and related to vascular complications. AIM: To assess the percentage of CD4(+) CD28(null) T-lymphocytes in children and adolescents with T1DM and their relation to vascular structure and glycemic control...
January 19, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28101819/high-central-aortic-rather-than-brachial-blood-pressure-is-associated-with-carotid-wall-remodeling-and-increased-arterial-stiffness-in-childhood
#2
Gonzalo Peluso, Victoria García-Espinosa, Santiago Curcio, Marco Marota, Juan Castro, Pedro Chiesa, Gustavo Giachetto, Daniel Bia, Yanina Zócalo
INTRODUCTION: In adults, central blood pressure (cBP) is reported to associate target organ damages (TODs) rather than peripheral blood pressure (pBP). However, data regarding the association of pre-clinical TODs with cBP and pBP in pediatric populations are scarce. AIM: To evaluate in children and adolescents the importance of cBP and pBP levels, in terms of their association with hemodynamic and vascular changes. METHODS: 315 subjects [age (mean/range) 12/8-18 years] were included...
January 19, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28099971/warfarin-associated-nonuremic-calciphylaxis
#3
Wesley Yung-Hsu Yu, Tina Bhutani, Rachel Kornik, Laura B Pincus, Theodora Mauro, Michael D Rosenblum, Lindy P Fox
Importance: Classic calciphylaxis associated with renal failure is a life-threatening disease. Warfarin-associated calciphylaxis without renal injury has been described, but whether it is a subset of classic calciphylaxis or a different entity remains unknown. We describe 1 case of warfarin-associated calciphylaxis, present data from 2 others from our institution, and review all cases of warfarin-associated calciphylaxis available in the literature. Our review indicates that warfarin-associated calciphylaxis is clinically and pathophysiologically distinct from classic calciphylaxis...
January 11, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28095749/obese-adolescents-with-polycystic-ovarian-syndrome-have-elevated-cardiovascular-disease-risk-markers
#4
Sonali S Patel, Uyen Truong, Martina King, Annie Ferland, Kerrie L Moreau, Jennifer Dorosz, John E Hokanson, Hong Wang, Gregory L Kinney, David M Maahs, Robert H Eckel, Kristen J Nadeau, Melanie Cree-Green
Women with polycystic ovarian syndrome (PCOS) have evidence of subclinical cardiovascular disease (CVD). However, insulin resistance, an important factor in the development of CVD in adults, is common in adolescents with PCOS, yet data in adolescents are limited. Therefore, we sought to measure insulin resistance and CVD markers in obese youth with and without PCOS. Thirty-six PCOS and 17 non-PCOS adolescent girls who were obese, sedentary, and non-hypertensive were recruited from clinics located within the Children's Hospital Colorado...
January 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28093467/blood-pressure-trajectories-from-childhood-to-young-adulthood-associated-with-cardiovascular-risk-results-from-the-23-year-longitudinal-georgia-stress-and-heart-study
#5
Guang Hao, Xiaoling Wang, Frank A Treiber, Gregory Harshfield, Gaston Kapuku, Shaoyong Su
The purpose of this study is to identify subgroups of individuals with similar trajectories in blood pressure (BP) from childhood to young adulthood and to determine the relationship of BP trajectories with carotid intima-media thickness (IMT) and left ventricular mass index (LVMI). BP was measured ≤16 times during a 23-year period in 683 participants from childhood to young adulthood. IMT and LVMI were measured in 551 participants and 546 participants, respectively. Using latent class models, 3 trajectory groups in BP from childhood to young adulthood were identified, including high-increasing, moderate-increasing, and low-increasing groups...
January 16, 2017: Hypertension
https://www.readbyqxmd.com/read/28092462/adolescent-cardiovascular-functional-and-structural-outcomes-of-growth-trajectories-from-infancy-prospective-community-based-study
#6
Alanna N Hanvey, Fiona K Mensah, Susan A Clifford, Melissa Wake
BACKGROUND: Adult BMI trajectories outperform single BMI measurements as predictors of cardiovascular mortality; however, it is unknown whether this also holds in childhood. We aimed to identify BMI trajectory categories from birth to adolescence, and examine their associations with adolescent cardiovascular function and structure. METHODS: Adolescents from a community-based prospective birth cohort completed 11-16 BMI measurements between birth and adolescence...
January 16, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28079791/a-possible-new-approach-in-the-prediction-of-late-gestational-hypertension-the-role-of-the-fetal-aortic-intima-media-thickness
#7
Silvia Visentin, Ambrogio P Londero, Martina Camerin, Enrico Grisan, Erich Cosmi
The aim was to determine the predictive role of combined screening for late-onset gestational hypertension by fetal ultrasound measurements, third trimester uterine arteries (UtAs) Doppler imaging, and maternal history. This prospective study on singleton pregnancies was conducted at the tertiary center of Maternal and Fetal Medicine of the University of Padua during the period between January 2012 and December 2014. Ultrasound examination (fetal biometry, fetal wellbeing, maternal Doppler study, fetal abdominal aorta intima-media thickness [aIMT], and fetal kidney volumes), clinical data (mother age, prepregnancy body mass index [BMI], and parity), and pregnancy outcomes were collected...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28078820/improvement-of-the-in-vivo-cellular-repopulation-of-decellularized-cardiovascular-tissues-by-a-detergent-free-non-proteolytic-actin-disassembling-regimen
#8
Alexander Assmann, Marc Struß, Franziska Schiffer, Friederike Heidelberg, Hiroshi Munakata, Elena V Timchenko, Pavel E Timchenko, Tim Kaufmann, Khon Huynh, Yukiharu Sugimura, Quentin Leidl, Antonio Pinto, Volker R Stoldt, Artur Lichtenberg, Payam Akhyari
Low immunogenicity and high repopulation capacity are crucial determinants for the functional and structural performance of acellular cardiovascular implants. The present study evaluates a detergent-free, non-proteolytic, actin-disassembling regimen (BIO) for decellularization of heart valve and vessel grafts, particularly focusing on their bio-functionality. Rat aortic conduits (rAoC; n = 89) and porcine aortic valve samples (n = 106) are decellularized using detergents (group DET) or the BIO regimen...
January 11, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28074304/evaluation-of-endothelial-dysfunction-in-patients-with-familial-mediterranean-fever-the-relationship-between-the-levels-of-asymmetric-dimethylarginine-and-endocan-with-carotid-intima-media-thickness-and-endothelium-dependent-vasodilation
#9
Veysel Ozalper, Muammer Kara, Alpaslan Tanoglu, Ibrahim Cetındaglı, Coskun Ozturker, Yusuf Hancerlı, Serdar Hıra, Kemal Kara, Yavuz Beyazıt, Yusuf Yazgan
It has been suggested that there is an ongoing subclinical inflammation in familial Mediterranean fever (FMF) patients also in attack-free periods as well. Due to this ongoing inflammation, endothelial dysfunction (ED) may develop. Previously, ED has been suggested to increase the risk of the atherosclerosis and cardiovascular disease (CVD). Endocan is recognized as a specific molecule of the endothelium and has been shown to increase in some cases associated with inflammation. However, there is not sufficient data whether those with FMF could develop ED in the early period of life...
January 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28074153/effects-of-metabolic-syndrome-on-aortic-pulse-wave-velocity
#10
Dong-Hyeon Lee, Ho-Joong Youn, Woo-Baek Chung, Yun-Seok Choi, Jong-Min Lee, Chul-Soo Park, Hae-Ok Jung, Hui-Kyung Jeon, Man-Young Lee
BACKGROUND: The purpose of this study was to compare the value and evaluate the validity of non-invasive methods for the detection of vascular stiffness in never-treated individuals with metabolic syndrome (MetS). METHODS: A total of 59 subjects (mean age, 60 ± 12 years; male:female = 35:24) were enrolled in the study and were categorized into the positive MetS (MetS[+]: N = 32) and negative group (MetS[-]: N = 27), according to the parameters set by the National Cholesterol Education Program's Adult Treatment Panel III...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28072557/expression-and-localization-of-the-at1-and-at2-angiotensin-ii-receptors-and-%C3%AE-1a-and-%C3%AE-1d-adrenergic-receptors-in-aorta-of-hypertensive-and-diabetic-rats
#11
Jessica Edith Rodríguez, Rodrigo Romero-Nava, Aldo Arturo Reséndiz-Albor, Erika Rosales-Cruz, Enrique Hong, Fengyang Huang, Santiago Villafaña
Hypertension and diabetes are multifactorial diseases that frequently coexist and exacerbate each another. During the development of diabetes, the impairment of noradrenergic and renin-angiotensin systems has been reported in the response mediated by α1-AR and AT1 receptors. Although their participation in the development of cardiovascular complications is still controversial, some studies have found increased or diminished response to the vasoconstrictive effect of noradrenaline or angiotensin II in a time-dependent manner of diabetes...
January 10, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28068655/carotid-intima-media-thickness-in-children-treated-with-growth-hormone-a-follow-up-study-over-three-years
#12
Juliane Rothermel, Caroline Knop, Nina Lass, Christina Toschke, Rainer Wunsch, Thomas Reinehr
BACKGROUND: There is an ongoing discussion whether high doses of growth hormone (GH) may lead to cardiovascular diseases. Therefore, we studied the longitudinal relationships between GH treatment and carotid intima-media thickness (cIMT), which is predictive of the development of atherosclerosis. METHODS: We measured blood pressure, lipids, hemoglobin HbA1c, IGF-1, IGFBP-3, and cIMT in 28 children treated with supraphysiological doses of GH (mean age 9.8 ± 2.2 years, 39% males) and 36 children suffering from GH deficiency (GHD) and treated with physiological doses of GH (mean age 9...
January 10, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28068636/citrus-leaf-extract-reduces-blood-pressure-and-vascular-damage-in-repeatedly-heated-palm-oil-diet-induced-hypertensive-rats
#13
Hawa Nordin Siti, Yusof Kamisah, Mohd Ishak Nur Iliyani, Suhaila Mohamed, Kamsiah Jaarin
Prolonged consumption of repeatedly heated vegetable oil increases blood pressure. This study aimed to determine the effects of Citrus leaf extract, (CLE) on blood pressure, blood pressure-regulating enzymes and mediators, as well as aortic histomorphometry in heated palm oil induced-hypertension. Male Sprague Dawley rats (n=56) were divided into seven groups; control group was given normal diet and the other groups were fed with palm oil-enriched diet (15% w/w) either fresh (FPO), five-time-heated (5HPO) or ten-time-heated (10HPO) with or without CLE (0...
January 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28068512/modulation-of-intersectin-1s-lung-expression-induces-obliterative-remodeling-and-severe-plexiform-arteriopathy-in-the-murine-pulmonary-vascular-bed
#14
Monal Patel, Dan Predescu, Cristina Bardita, Jiwang Chen, Niranjan Jeganathan, Melanie Pritchard, Salvatore DiBartolo, Roberto Machado, Sanda Predescu
Murine models of pulmonary arterial hypertension (PAH) that recapitulate the plexiform and obliterative arteriopathy seen in PAH patients and help in defining the molecular mechanisms involved are missing. Herein, we investigated whether intersectin-1s (ITSN) deficiency and prolonged lung expression of an ITSN fragment with endothelial cell (EC) proliferative potential (EHITSN), present in the lungs of PAH animal models and human patients, induce formation of plexiform/obliterative lesions and defined the molecular mechanisms involved...
January 6, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28067869/clinical-and-biological-markers-of-premature-aging-after-autologous-sct-in-childhood-cancer
#15
A Vatanen, M Hou, T Huang, O Söder, T Jahnukainen, M Kurimo, T H Ojala, T Sarkola, M Turanlahti, U M Saarinen-Pihkala, K Jahnukainen
The aim of this study was to analyze the prevalence of frailty and physical health limitations among long-term survivors of high-risk neuroblastoma (HR NBL) and to investigate whether frail health is associated with variables of cardiovascular function, markers of inflammation and telomere length. A national study cohort of 19 (median age 22, range 16-30 years) long-term (>10 years) HR NBL survivors was studied and the findings were compared with 20 age- and sex-matched controls. Frailty was defined as ⩾3 of the following conditions: low muscle mass, low energy expenditure, slow running and weakness...
January 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28067320/relationship-between-frequency-of-hypoglycemic-episodes-and-changes-in-carotid-atherosclerosis-in-insulin-treated-patients-with-type-2-diabetes-mellitus
#16
Tomoya Mita, Naoto Katakami, Toshihiko Shiraiwa, Hidenori Yoshii, Nobuichi Kuribayashi, Takeshi Osonoi, Hideaki Kaneto, Keisuke Kosugi, Yutaka Umayahara, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada
The effect of hypoglycemia on the progression of atherosclerosis in patients with type 2 diabetes mellitus (T2DM) remains largely unknown. This is a post hoc analysis of a randomized trial to investigate the relationship between hypoglycemic episodes and changes in carotid intima-media thickness (IMT). Among 274 study subjects, 104 patients experienced hypoglycemic episodes. Increases in the mean IMT and left maximum IMT of the common carotid arteries (CCA) were significantly greater in patients with hypoglycemia compared to those without hypoglycemia...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28066586/nanoparticle-mediated-arresten-gene-inhibits-neointimal-formation-of-vein-grafts-an-experimental-research
#17
Rong-Fei Wang, Qing-Yi Meng
BACKGROUND: Recently, we established a new rat model of venous arterialization by grafting the jugular vein into carotid arteries. In many respects, the morphological features of this murine vascular graft model resemble those of human venous bypass graft diseases. Using this model, we studied nanoparticles that mediated the arresten gene to inhibit the neointimal formation of vein grafts. METHODS: Thirty healthy Wistar female rats were randomly divided into three groups...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28064231/effects-of-therapy-with-maraviroc-on-the-carotid-intima-media-thickness-in-hiv-1-hcv-co-infected-patients
#18
Paolo Maggi, Giuseppe Bruno, Francesco Perilli, Annalisa Saracino, Anna Volpe, Carmen Santoro, Nicoletta Ladisa, Gioacchino Angarano
AIM: To evaluate, in human immunodeficiency virus-hepatitis C virus co-infected patients, the impact of C-C chemokine receptor type 5 (CCR5) antagonist maraviroc-based antiretroviral therapy on the carotid intima media thickness and on atheromasic plaques. PATIENTS AND METHODS: In this pilot prospective study, 12 HIV-HCV co-infected patients underwent color-Doppler ultrasonography before and 48 weeks after switching to a dual therapy based on maraviroc plus protease inhibitors boosted with ritonavir...
January 2017: In Vivo
https://www.readbyqxmd.com/read/28063931/long-noncoding-rna-h19-derived-mir-675-aggravates-restenosis-by-targeting-pten
#19
Junyuan Lv, Lei Wang, Jin Zhang, Ruoran Lin, Lun Wang, Weifeng Sun, Huize Wu, Shijie Xin
Restenosis is mainly attributed to excessive proliferation of vascular smooth muscle cells (VSMCs). Noncoding RNAs have been identified as key regulators of diverse pathological processes. We reported that the long noncoding RNA H19 (LncRNA H19) and LncRNA H19-derived microRNA (miR-675) are overexpressed in neointima of balloon-injured artery. Thus, the present study aims to evaluate the role of LncRNA H19 on VSMCs proliferation. To determine the changes of LncRNA H19 and miR-675 expression in the injured arterial wall, the standard rat carotid artery balloon injury model was used...
January 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28062999/relationship-between-increased-carotid-artery-stiffness-and-idiopathic-subjective-tinnitus
#20
C Bayraktar, S Taşolar
Tinnitus is defined as perception of sound with no external stimulus, and can separate into pulsatile and non-pulsatile types. Arterial stiffness is a parameter that can predict the cardiovascular event and associated with incidence of stroke. It has been shown that increased arterial stiffness may lead to microvascular damage in brain. Our aim was to assess the arterial stiffness of the carotid system in the development and severity of idiopathic subjective tinnitus. Forty subjective tinnitus patients and 40 age- and sex-matched controls were enrolled in the study...
January 6, 2017: European Archives of Oto-rhino-laryngology
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