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Heterotopic ossification

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https://www.readbyqxmd.com/read/29451051/influence-of-surgical-approach-on-complication-risk-in-primary-total-hip-arthroplasty
#1
Larry E Miller, Joseph S Gondusky, Atul F Kamath, Friedrich Boettner, John Wright, Samir Bhattacharyya
Background and purpose - Systematic comparisons of anterior approach (A) versus posterior approach (P) in primary total hip arthroplasty (THA) have largely focused on perioperative outcomes. In this systematic review with meta-analysis, we compared complication risk of A versus P in studies of primary THA with at least 1-year mean follow-up. Patients and methods - We performed a systematic review of prospective and retrospective studies with at least 1-year mean follow-up that reported complications of A and P primary THA...
February 16, 2018: Acta Orthopaedica
https://www.readbyqxmd.com/read/29451004/simulating-localised-cellular-inflammation-and-substrate-properties-in-a-strain-energy-density-based-bone-remodelling-algorithm-for-use-in-modelling-trauma
#2
Naomi Rosenberg, Anthony M J Bull
Bone responds to mechanical stimulus and a range of pre-existing finite element models have been suggested to reproduce the internal physiological structure of bone. Inflammation effects are not included in these models, yet inflammation is a key component of bone repair in trauma. Therefore, a model is proposed and tested here that extends these methods to include parameters that could be considered to represent the behaviour of bone remodelling when influenced by inflammation. The proposed model regulates remodelling based on findings from recent studies into the nature of heterotopic ossification, the formation of heterotopic bone, which have revealed information about the nature of bone after high levels of trauma...
February 16, 2018: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29447305/pseudo-pedicle-heterotopic-ossification-from-use-of-recombinant-human-bone-morphogenetic-protein-2-rhbmp-2-in-transforaminal-lumbar-interbody-fusion-cages
#3
Charles D Rosen, P Douglas Kiester, Thay Q Lee
We conducted a study to determine the common characteristics of patients who developed radiculopathy symptoms and corresponding heterotopic ossification (HO) from transforaminal lumbar interbody fusions (TLIF) using recombinant human bone morphogenetic protein 2 (rhBMP-2). HO can arise from a disk space with rhBMP-2 use in TLIF. Formation of bone around nerve roots or the thecal sac can cause a radiculopathy with a consistent pattern of symptoms. We identified 38 patients (26 males, 12 females) with a mean (SD) age of 50...
January 2018: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29445932/fibrodysplasia-ossificans-progressiva-a-current-review-of-imaging-findings
#4
REVIEW
Adam H Bauer, Jeff Bonham, Luis Gutierrez, Edward C Hsiao, Daria Motamedi
OBJECTIVE: Fibrodysplasia ossificans progressiva is a rare genetic disorder characterized by congenital skeletal deformities and soft tissue masses that progress to heterotopic ossification. Deformities of the great toes are distinctive, and heterotopic ossification in the soft tissues follows an expected anatomic and temporal pattern. In addition to heterotopic ossification, osteochondromata, middle ear ossification, demyelination, lymphedema, and venous thrombosis are characteristic...
February 14, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29439770/heterotopic-ossification-in-a-dialysis-patient
#5
Igor Alexander Harsch
No abstract text is available yet for this article.
February 2, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29433643/prevalence-and-clinical-outcomes-of-heterotopic-ossification-after-ulnar-collateral-ligament-reconstruction
#6
Jin-Young Park, Beom Ho Seo, Kyung-Ho Hong, Jae-Hyung Lee, Kyung-Soo Oh, Seok Won Chung, Young-Min Noh
BACKGROUND: Ulnar collateral ligament (UCL) reconstruction has become increasingly popular in elite athletes. However, the prevalence of heterotopic ossification (HO) formation after UCL reconstruction has not yet been reported. We sought to determine the prevalence of HO formation after UCL reconstruction and the clinical outcomes following HO treatment. MATERIALS AND METHODS: From October 2005 to April 2014, 179 patients underwent primary UCL reconstruction. Of the 179 patients, 161 with a minimum of 2 years of follow-up were retrospectively reviewed to evaluate HO formation and clinical outcomes...
March 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29432987/3d-printed-microchannel-networks-to-direct-vascularisation-during-endochondral-bone-repair
#7
Andrew C Daly, Pierluca Pitacco, Jessica Nulty, Gráinne M Cunniffe, Daniel J Kelly
Bone tissue engineering strategies that recapitulate the developmental process of endochondral ossification offer a promising route to bone repair. Clinical translation of such endochondral tissue engineering strategies will require overcoming a number of challenges, including the engineering of large and often anatomically complex cartilage grafts, as well as the persistence of core regions of avascular cartilage following their implantation into large bone defects. Here 3D printing technology is utilized to develop a versatile and scalable approach to guide vascularisation during endochondral bone repair...
February 1, 2018: Biomaterials
https://www.readbyqxmd.com/read/29427092/treatment-of-tibial-nonunion-with-bone-defect-using-a-heterotopic-ossification-as-autologous-bone-graft-literature-overview-and-case-report
#8
REVIEW
Michael Schlumberger, Raul Mayr, Christian Koidl, Martin Eichinger, Tobias Roth
INTRODUCTION: Nonunion after open fracture of the lower leg is a frequent complication with a prevalence of up to 40%. In cases with major bone defects, revision of the osteosynthesis with bone grafting is commonly performed. Until today, there is no report on treatment of a tibial nonunion with transplantation of a heterotopic ossification. PRESENTATION OF CASE: We present a case of a 27-year-old male patient, who suffered from a paragliding accident with major injuries...
February 9, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29424159/-minimally-invasive-internal-fixation-of-pelvic-ring-for-type-c-pelvic-fracture
#9
Chun-Hui Tang, Gao-Wen Yao, Lin Wang, Hong-Liang Tu, Wei Luo
OBJECTIVE: To evaluate the feasibility of minimally invasive internal fixation of pelvic anterior and posterior ring for the treatment of type C pelvic fracture, and to explore its operative techniques and therapeutic efficacy. METHODS: From December 2010 to December 2015, 18 patients with type C pelvic fracture were treated by reconstructive plates fixation through minimally invasive ilioinguinal approach for pelvic anterior ring injuries, and by invasive percutaneous sacroiliac joint screw fixation for pelvic posterior ring injuries...
July 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29424152/-application-of-the-computer-assisted-virtual-reduction-combined-with-3d-printing-technique-in-acetabular-fractures
#10
Yu-Chen Wang, Yong Ma, Wei-Zhong Yu, Yun-Feng Li, Yan-Hui Liu
OBJECTIVE: To investigate the computer-assisted virtual reduction combined with 3D printing technique as preoperative planning and assess their therapeutic effects. METHODS: Thirty-five cases of acetabular fracture treated by internal fixation from March 2011 and March 2014 were retrospectively analyzed. All patients underwent operations with internal fixations implanted. The patients were divided into 2 groups according whether they used the computer-assisted virtual reduction combined with 3D printing technology...
July 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29424150/-treatment-of-pipkin-type-i-and-ii-femoral-head-fractures-through-modified-smith-peterson-approach-and-modified-hardinge-approach-a-case-control-studies
#11
Yu-Qing Jiang, Jian Huang, Wei-Kang Guo, Bing Lai, Jun Wang, Chuan-Xing Liang, Song-Lang Liu, Wei-Ming Lin
OBJECTIVE: To compare clinical results of treatment of Pipkin type I and II femoral head fractures through modified Smith-Peterson(S-P) approach and modified Hardinge approach. METHODS: From July 2005 to July 2014, 42 patients with Pipkin type I and II femoral head fractures were treated with operation. A total of 23 patients in anterior group was treated with modified S-P approach including 17 males and 6 females with an average age of (29.3±9.4) years old, 5 cases of type I by excision of the fragement, 3 cases of type I and 15 cases of type II cases by fixation of the fragement...
July 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29423245/refractory-pain-following-hip-arthroscopy-evaluation-and-management
#12
REVIEW
Jason J Shin, Darren L de Sa, Jeremy M Burnham, Craig S Mauro
With increased knowledge and understanding of hip pathology, hip arthroscopy is rapidly becoming a popular treatment option for young patients with hip pain. Despite improved clinical and radiographic outcomes with arthroscopic treatment, some patients may have ongoing pain and less than satisfactory outcomes. While the reasons leading to failed hip arthroscopy are multifactorial, patient selection, surgical technique and rehabilitation all play a role. Patients with failed hip arthroscopy should undergo a thorough history and physical examination, as well as indicated imaging...
January 2018: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/29416028/inhibition-of-overactive-tgf-%C3%AE-attenuates-progression-of-heterotopic-ossification-in-mice
#13
Xiao Wang, Fengfeng Li, Liang Xie, Janet Crane, Gehua Zhen, Yuji Mishina, Ruoxian Deng, Bo Gao, Hao Chen, Shen Liu, Ping Yang, Manman Gao, Manli Tu, Yiguo Wang, Mei Wan, Cunyi Fan, Xu Cao
Acquired heterotopic ossification (HO) is a painful and debilitating disease characterized by extraskeletal bone formation after injury. The exact pathogenesis of HO remains unknown. Here we show that TGF-β initiates and promotes HO in mice. We find that calcified cartilage and newly formed bone resorb osteoclasts after onset of HO, which leads to high levels of active TGF-β that recruit mesenchymal stromal/progenitor cells (MSPCs) in the HO microenvironment. Transgenic expression of active TGF-β in tendon induces spontaneous HO, whereas systemic injection of a TGF-β neutralizing antibody attenuates ectopic bone formation in traumatic and BMP-induced mouse HO models, and in a fibrodysplasia ossificans progressive mouse model...
February 7, 2018: Nature Communications
https://www.readbyqxmd.com/read/29412179/high-frequency-spectral-ultrasound-imaging-susi-visualizes-early-post-traumatic-heterotopic-ossification-ho-in-a-mouse-model
#14
Kavitha Ranganathan, Xiaowei Hong, David Cholok, Joe Habbouche, Caitlin Priest, Christopher Breuler, Michael Chung, John Li, Arminder Kaura, Hsiao Hsin Sung Hsieh, Jonathan Butts, Serra Ucer, Ean Schwartz, Steven R Buchman, Jan P Stegemann, Cheri X Deng, Benjamin Levi
PURPOSE: Early treatment of heterotopic ossification (HO) is currently limited by delayed diagnosis due to limited visualization at early time points. In this study, we validate the use of spectral ultrasound imaging (SUSI) in an animal model to detect HO as early as one week after burn tenotomy. METHODS: Concurrent SUSI, micro CT, and histology at 1, 2, 4, and 9weeks post-injury were used to follow the progression of HO after an Achilles tenotomy and 30% total body surface area burn (n=3-5 limbs per time point)...
February 6, 2018: Bone
https://www.readbyqxmd.com/read/29409971/stem-cells-and-heterotopic-ossification-lessons-from-animal-models
#15
REVIEW
John B Lees-Shepard, David J Goldhamer
Put most simply, heterotopic ossification (HO) is the abnormal formation of bone at extraskeletal sites. HO can be classified into two main subtypes, genetic and acquired. Acquired HO is a common complication of major connective tissue injury, traumatic central nervous system injury, and surgical interventions, where it can cause significant pain and postoperative disability. A particularly devastating form of HO is manifested in the rare genetic disorder, fibrodysplasia ossificans progressiva (FOP), in which progressive heterotopic bone formation occurs throughout life, resulting in painful and disabling cumulative immobility...
January 30, 2018: Bone
https://www.readbyqxmd.com/read/29408574/clinical-and-radiological-features-of-three-reconstructive-procedures-for-the-surgical-management-of-patients-with-bi-level-cervical-degenerative-disc-disease-at-a-minimum-follow-up-period-of-five-years-a-comparative-study
#16
Kai-Feng Wang, Shuo Duan, Zhen-Qi Zhu, Hai-Ying Liu, Chen-Jun Liu, Shuai Xu
OBJECTIVE: To assess the mid-long-term follow-up of the safety and efficacy of anterior cervical discectomy and fusion (ACDF), cervical artificial disc replacement (CADR) and hybrid surgery (HS) for bi-level cervical degenerative disc disease (cDDD). METHODS: 77 patients who underwent ACDF, HS and CADR were retrospectively reviewed. Clinical effects were evaluated based on NDI, VAS and JOA scores, and the Odom criteria. Radiographic outcomes were evaluated, including cervical range of motion(ROM), operative and adjacent segments ROM, incidence of adjacent segments degeneration(ASD) and heterotopic ossification(HO)...
January 30, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29402719/intramedullary-devices-in-the-management-of-judet-iii-and-iv-paediatric-radial-neck-fractures
#17
Manish Kiran, Colin Bruce, Harvey George, Neeraj Garg, Roger Walton
PURPOSE: The aim of this study is to discuss the results of different intramedullary devices used in the management of paediatric radial neck fractures and to suggest methods to avoid the pitfalls of the technique. METHODS: Thirty patients with isolated Judet III and IV fractures were included in this prospective study. Judet I and II fractures and radial neck fractures associated with other injuries were excluded. The final results were graded using the Metaizeau functional scoring system and Oxford Elbow Score...
December 9, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29397526/heterotopic-ossifications-role-of-radiotherapy-as-prophylactic-treatment
#18
Maria Grazia Ruo Redda, Chiara De Colle, Lavinia Bianco, Andrea Ruggieri, Daniela Nassisi, Annalisa Rossi, Eva Gino, Claudia Airaldi
BACKGROUND: Heterotopic ossification (HO) is abnormal formation of lamellar bone in soft tissue; the most frequent causes are total hip arthroplasty and trauma. Severe cases can lead to ankilosis with important impact on quality of life. Surgery is the elective treatment, but, especially in high-risk patients, it is important to prevent the re-formation of HO and, in these cases, radiotherapy (RT) can play an important role. MATERIALS AND METHODS: we retrospectively analyzed a mono-institutional casistic of 30 patients (31 sites) at high risk for HO development, treated with surgery and pre- or postoperative RT...
February 3, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29396429/activin-dependent-signaling-in-fibro-adipogenic-progenitors-causes-fibrodysplasia-ossificans-progressiva
#19
John B Lees-Shepard, Masakazu Yamamoto, Arpita A Biswas, Sean J Stoessel, Sarah-Anne E Nicholas, Cathy A Cogswell, Parvathi M Devarakonda, Michael J Schneider, Samantha M Cummins, Nicholas P Legendre, Shoko Yamamoto, Vesa Kaartinen, Jeffrey W Hunter, David J Goldhamer
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disorder characterized by progressive and profoundly disabling heterotopic ossification (HO). Here we show that fibro/adipogenic progenitors (FAPs) are a major cell-of-origin of HO in an accurate genetic mouse model of FOP (Acvr1 tnR206H ). Targeted expression of the disease-causing type I bone morphogenetic protein (BMP) receptor, ACVR1(R206H), to FAPs recapitulates the full spectrum of HO observed in FOP patients. ACVR1(R206H)-expressing FAPs, but not wild-type FAPs, activate osteogenic signaling in response to activin ligands...
February 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29393031/-heterotopic-ossification-in-a-midline-incision
#20
Camilla Ibsen Hauge, Jacob Kvist Poulsen
Heterotopic ossification (HO) is the formation of bone outside the skeletal system. It is a well-known complication in orthopaedic surgery but is infrequently reported in abdominal surgery. HO can be asymptomatic or cause chronic pain but can also cause complications during later surgery. In this case report we present a 54-year-old male with an HO in a midline incision following surgery 20 years earlier.
January 22, 2018: Ugeskrift for Laeger
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