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Heterotopic ossification

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https://www.readbyqxmd.com/read/29054353/the-rate-of-radial-head-prosthesis-removal-or-revision-a-systematic-review-and-meta-analysis
#1
Amir R Kachooei, Aslan Baradaran, Mohammad H Ebrahimzadeh, C Niek van Dijk, Neal Chen
PURPOSE: We conducted a meta-analysis and systematic review with the primary objective to determine the overall incidence of radial head prosthesis removal or revision. Our secondary objectives addressed the incidence of removal or revision based on the type of prosthesis fixation (cemented, uncemented smooth stem, uncemented press-fit), material (metal, Vitallium, titanium, pyrocarbon), and design (short vs long stem and monopolar vs bipolar), and the reasons for prosthetic removal or revision...
October 18, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29033382/clinical-pathological-correlations-in-three-patients-with-fibrodysplasia-ossificans-progressiva
#2
Kelly L Wentworth, Katherine Bigay, Tea V Chan, Jennifer P Ho, Blanca M Morales, Joseph Connor, Erin Brooks, M Shahriar Salamat, Henry Charles Sanchez, Geoffrey Wool, Robert J Pignolo, Frederick S Kaplan, Edward C Hsiao
OBJECTIVE: Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder in which heterotopic bone forms in the soft tissues. This often occurs in response to injury or inflammation, leading to joint immobilization and significant disability. There are currently no definitive treatment options for this devastating disease. Although the most dramatic phenotype in FOP is the episodic and progressive heterotopic ossification, patients report a number of symptoms that affect other organ systems...
October 12, 2017: Bone
https://www.readbyqxmd.com/read/29029772/inhibition-of-mammalian-target-of-rapamycin-signaling-with-rapamycin-prevents-trauma-induced-heterotopic-ossification
#3
Ammar T Qureshi, Devaveena Dey, Erin M Sanders, Jonathan G Seavey, Allison M Tomasino, Kaitlyn Moss, Benjamin Wheatley, David Cholok, Shawn Loder, John Li, Benjamin Levi, Thomas A Davis
A pressing clinical need exists for 63% to 65% of combat-wounded service members and 11% to 20% of civilians who develop heterotopic ossification (HO) after blast-related extremity injury and traumatic injuries, respectively. The mammalian target of rapamycin pathway is a central cellular sensor of injury. We evaluated the prophylactic effects of rapamycin, a selective inhibitor of mammalian target of rapamycin signaling, on HO formation in a rat model of blast-related, polytraumatic extremity injury. Rapamycin was administered intraperitoneally daily for 14 days at 0...
October 5, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29027640/the-utility-of-botulinum-toxin-a-in-the-repair-of-distal-biceps-tendon-ruptures
#4
L S Khalil, R A Keller, N Mehran, N E Marshall, K Okoroha, N B Frisch, S P DeSilva
PURPOSE: The purpose of our study is to report the outcomes and complications in patients who underwent distal biceps tendon repair with the use of Botulinum toxin A (BoNT-A) as an adjunct to surgery. METHODS: A retrospective review of 14 patients who underwent 15 distal biceps tendon repairs was performed. All repaired tendons had their correlating muscle bellies injected intraoperatively with a mixture of 100U of BoNT-A and 10 ml of normal saline. Each patient was evaluated for surgical and post-operative complications and followed with Disabilities of the Arm, Shoulder and Hand (DASH) Disability Scores...
October 13, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29027187/midterm-results-of-trochanteric-flip-osteotomy-technique-for-management-of-fractures-around-the-hip
#5
Vivek Trikha, Saubhik Das, Arkesh Madegowda, Prabhat Agrawal
INTRODUCTION: In this study, we aimed to investigate safety and efficacy of the trochanteric flip osteotomy with surgical hip dislocation technique in selected displaced acetabular and femoral head fractures with clinico-radiological outcome and potential complications. MATERIALS AND METHODS: We retrospectively reviewed 32 patients from January 2009 to June 2014. Selected displaced acetabular fractures with comminution and/or cranial extension of posterior wall, marginal impaction, intraarticular fragment, femoral head fractures and hip fracture-dislocations were operated by this modified approach of trochanteric flip osteotomy and surgical hip dislocation...
October 9, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29020815/-bony-cubital-tunnel-syndrome-caused-by-heterotopic-ossification
#6
Yuxuan Wu, Meng Liu, Wei Qu
We reported a rare case of cubital tunnel syndrome caused by heterotopic ossification after burns. The ulnar nerve was encircled by bony tunnel structure which cause nerve compression, resulting in ulnar nerve lesion. Our case sheds light on possible etiological association which may help clinical management.
October 11, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28993981/surgical-treatment-of-marginal-osteochondral-impaction-in-acetabular-fractures
#7
Y M Khira, S El-Aidy
PURPOSE: Clinical and radiological evaluation of the results of the technique of elevation and grafting of osteochondral marginal impaction fragment of posterior wall acetabular fractures. METHODS: Twenty patients available for this study had fracture acetabulum with marginal impaction fragment. Elevation, reduction and bone graft impaction of the defect were the technique in all cases. Follow-up was at least for 1 year. Evaluation of patient was done clinically by modified Merle d'Aubigné and Postel score and radiologically by Matta's criteria of reduction quality and that of radiological hip evaluation...
October 9, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28993082/noncemented-total-hip-arthroplasty-in-sickle-cell-disease-long-term-results
#8
Imran Ilyas, Husam A Alrumaih, Samar Rabbani
BACKGROUND: Avascular necrosis of the femoral head is a well-known sequela of sickle-cell disease (SCD) requiring a surgical intervention that comes with technical challenges. METHODS: Uncemented hip arthroplasty for avascular necrosis of the femoral head due to SCD was carried out for 101 patients (133 hips) between 2000 and 2012. The duration of follow-up ranged from 5 to 17 years (mean, 14.59 years). All patients received a noncemented femoral stem and a noncemented acetabular shell...
September 14, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28987285/heterotopic-ossification-and-the-elucidation-of-pathologic-differentiation
#9
David Cholok, Michael T Chung, Kavitha Ranganathan, Serra Ucer, Devaveena Day, Thomas A Davis, Yuji Mishina, Benjamin Levi
Tissue regeneration following acute or persistent inflammation can manifest a spectrum of phenotypes ranging from the adaptive to the pathologic. Heterotopic Ossification (HO), the endochondral formation of bone within soft-tissue structures following severe injury serves as a prominent example of pathologic differentiation; and remains a persistent clinical issue incurring significant patient morbidity and expense to adequately diagnose and treat. The pathogenesis of HO provides an intriguing opportunity to better characterize the cellular and cell-signaling contributors to aberrant differentiation...
October 4, 2017: Bone
https://www.readbyqxmd.com/read/28986986/depletion-of-mast-cells-and-macrophages-impairs-heterotopic-ossification-in-an-acvr1-r206h-mouse-model-of-fibrodysplasia-ossificans-progressiva
#10
Michael R Convente, Salin A Chakkalakal, EnJun Yang, Robert J Caron, Deyu Zhang, Taku Kambayashi, Frederick S Kaplan, Eileen M Shore
Heterotopic ossification (HO) is a clinical condition that often reduces mobility and diminishes quality of life for affected individuals. The most severe form of progressive HO occurs in those with fibrodysplasia ossificans progressiva (FOP; OMIM #135100), a genetic disorder caused by a recurrent heterozygous gain-of-function mutation (R206H) in the bone morphogenetic protein (BMP) type I receptor ACVR1/ALK2. In individuals with FOP, episodes of HO frequently follow injury. The first sign of active disease is commonly an inflammatory "flare-up" that precedes connective tissue degradation, progenitor cell recruitment, and endochondral HO...
October 7, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28985649/peripheral-blood-mononuclear-cell-immunophenotyping-in-fibrodysplasia-ossificans-progressiva-patients-evidence-for-monocyte-dnam1-up-regulation
#11
Genny Del Zotto, Francesca Antonini, Irma Azzari, Claudio Ortolani, Gino Tripodi, Francesca Giacopelli, Serena Cappato, Lorenzo Moretta, Roberto Ravazzolo, Renata Bocciardi
Background Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disorder caused by sporadic heterozygous mutations in ACVR1 gene which progressively leads to severe heterotopic ossification. FOP is characterized by episodic flare-ups triggered by different factors such as viral infections, tissue injuries, vaccinations or occurring without a recognizable cause. The sporadic course of the disease, the documented presence of an important inflammatory reaction in early lesions and the partial response to corticosteroids support the idea that the immune system, and in particular the innate component, may play a role in FOP pathogenesis...
October 6, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28973309/nunec%C3%A2-cervical-disc-arthroplasty-improves-quality-of-life-in-cervical-radiculopathy-and-myelopathy-a-2-yr-follow-up
#12
Isobel Turner, David Choi
BACKGROUND: Anterior cervical disc replacement is an alternative to fusion for the treatment of selected cases of radiculopathy and myelopathy. We report clinical and radiological outcomes after disc replacement with the NuNec™ artificial cervical disc (Pioneer® Surgical Technology, Marquette, Michigan) with subgroup analysis. OBJECTIVE: To review clinical and radiological outcomes after anterior cervical disc replacement with the NuNec™ artificial cervical disc...
August 3, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28972793/potential-discrepancy-between-plain-films-and-ct-scans-in-brooker-classification-of-heterotopic-ossification
#13
Mary Jiayi Tao, Linda Probyn, Michael Poon, Hans Kreader, Markku Nousiainen, Richard Jenkinson, Bo Angela Wan, Tsao May, Barnes Elizabeth, Edward Chow
OBJECTIVE: The Brooker Classification is a commonly used tool to characterize the extent of heterotopic ossification (HTO), which is the dystrophic formation of mature lamellar bone in non-osseous tissues such as muscles, connective tissue, or nerves. We aim to provide illustrative cases to describe the limitations and challenges of this system. METHODS: A retrospective review was conducted in all patients who had retrieved hip and/or pelvic radiotherapy for HTO prophylaxis at our institution between July 1998 and August 2016...
October 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28971082/open-versus-arthroscopic-approach-in-the-treatment-of-femoroacetabular-impingement-a-case-control-study-with-two-years-follow-up
#14
Bruno Dutra Roos, Milton Valdomiro Roos, Antero Camisa Júnior, Ezequiel Moreno Ungaretti Lima, Maurício Domingos Betto
OBJECTIVE: To compare clinical and imaging results and complications between patients treated for femoroacetabular impingement (FAI) who underwent either anterior open surgery or an arthroscopic approach, with a minimum follow-up of two years. METHODS: This retrospective case-control study included patients submitted to FAI surgical treatment between November 2007 and March 2012. Patients treated with open surgery were compared with those treated with arthroscopy...
2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28965449/letter-to-the-editor-segmental-mobility-and-heterotopic-ossification-after-cervical-arthroplasty
#15
Junfeng Zeng, Hao Liu, Yi Yang
No abstract text is available yet for this article.
October 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28963665/locking-plate-and-fibular-strut-graft-augmentation-in-the-reconstruction-of-unicameral-bone-cyst-of-proximal-femur-in-the-paediatric-population
#16
Khodamorad Jamshidi, Masoud Mirkazemi, Azra Izanloo, Alireza Mirzaei
PURPOSE: Several therapeutic strategies have been used for managing unicameral bone cyst (UBC) of the proximal femur. However, there is insufficient evidence to support one treatment over another, and the optimal treatment is controversial. This study aims at describing our experience with surgical reconstruction of paediatric UBCs of the proximal femur using a proximal locking plate and fibular strut allograft. METHODS: In total, 14 consecutive paediatric patients with Dormans types IB (four cases) and IIB (10 cases) UBC were assessed...
September 30, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28963163/cemented-total-hip-arthroplasty-following-acetabular-fracture
#17
C E H Scott, D MacDonald, M Moran, T O White, J T Patton, J F Keating
AIMS: To evaluate the outcomes of cemented total hip arthroplasty (THA) following a fracture of the acetabulum, with evaluation of risk factors and comparison with a patient group with no history of fracture. PATIENTS AND METHODS: Between 1992 and 2016, 49 patients (33 male) with mean age of 57 years (25 to 87) underwent cemented THA at a mean of 6.5 years (0.1 to 25) following acetabular fracture. A total of 38 had undergone surgical fixation and 11 had been treated non-operatively; 13 patients died at a mean of 10...
October 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28963080/cartilage-derived-retinoic-acid-sensitive-protein-cd-rap-a-stage-specific-biomarker-of-heterotopic-endochondral-ossification-heo-in-fibrodysplasia-ossificans-progressiva-fop
#18
Carter M Lindborg, Tracy A Brennan, Haitao Wang, Frederick S Kaplan, Robert J Pignolo
BACKGROUND: Genesis of a cartilaginous scaffold is an obligate precursor to bone formation in heterotopic endochondral ossification (HEO). We tested the hypothesis that cartilage-derived retinoic acid-sensitive protein (CD-RAP) can serve as a plasma biomarker for the pre-osseous cartilaginous stage of HEO. Palovarotene, a retinoic acid receptor-gamma (RARγ) agonist, has been proposed as a possible treatment for fibrodysplasia ossificans progressiva (FOP) and is a potent inhibitor of HEO in mouse models...
September 28, 2017: Bone
https://www.readbyqxmd.com/read/28960501/palovarotene-inhibits-connective-tissue-progenitor-cell-proliferation-in-a-rat-model-of-combat-related-heterotopic-ossification
#19
Benjamin M Wheatley, Katherine E Cilwa, Devaveena Dey, Ammar T Qureshi, Jonathan G Seavey, Allison M Tomasino, Erin M Sanders, Wesley Bova, Cynthia A Boehm, Masahiro Iwamoto, Benjamin K Potter, Jonathan A Forsberg, George F Muschler, Thomas A Davis
Heterotopic ossification (HO) develops in the extremities of wounded service members and is common in the setting of high-energy penetrating injuries and blast-related amputations. No safe and effective prophylaxis modality has been identified for this patient population. Palovarotene has been shown to reduce bone formation in traumatic and genetic models of HO. The purpose of this study was to determine the effects of Palovarotene on inflammation, progenitor cell proliferation and gene expression following a blast-related amputation in a rodent model (n = 72 animals), as well as the ability of Raman spectroscopy to detect early HO before radiographic changes are present...
September 28, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28958658/a-minimum-ten-years-of-follow-up-of-alumina-head-on-delta-liner-total-hip-arthroplasty
#20
Won-Sik Choy, Yong-Han Cha, Chung-Youb Jeon, Kyu-Sang Lee, Ha-Yong Kim
BACKGROUND: In the early days when delta ceramics were developed, there was a period of using delta ceramic liner and alumina ceramic head. Therefore, the purpose of this study is to investigate the clinical and radiological outcomes of total hip arthroplasty using delta ceramic liner on alumina ceramic head after a minimum of 10 years of follow-up and to evaluate problems of early delta ceramic liner. METHODS: Alumina on delta cementless total hip arthroplasty was performed in 92 hips (85 patients) from August 2005 to March 2007 at our hospital...
September 7, 2017: Journal of Arthroplasty
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