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Heterotopic ossification

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https://www.readbyqxmd.com/read/29678845/the-use-of-type-i-collagen-cross-linked-c-telopeptide-ctx-1-as-a-biomarker-associated-with-the-formation-of-periprosthetic-ossifications-following-total-hip-joint-arthroplasty
#1
Paweł Łęgosz, Łukasz Pulik, Piotr Stępiński, Jakub Janowicz, Agnieszka Wirkowska, Andrzej Kotela, Sylwia Sarzyńska, Paweł Małdyk
The aim of this study was to determine the co-occurrence of heterotopic ossifications (HO) and elevated bone biomarkers level (urine type I collagen cross-linked C-telopeptide - CTX-1, serum alkaline phosphatase - ALP) and assess the effectiveness of pharmacological prophylaxis of HO. The study group consisted of (N=54) patients qualified for total hip arthroplasty. In N=19 (35%) patients new HO were formed (48th week vs to baseline). On baseline, the mean CTX-1 value in the HO (-) patients was 8.60+/-5.37 ug/mmol vs HO (+) 11...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29668642/operative-treatment-of-terrible-triad-of-the-elbow-with-a-modified-pugh-standard-protocol-retrospective-analysis-of-a-prospective-cohort
#2
Guanyi Liu, Weihu Ma, Ming Li, Jianxiang Feng, Rongming Xu, Zhijun Pan
The aim of the present study was to investigate the efficacy of the surgical treatment of terrible triad injuries of the elbow using a modified standard surgical approach, and treatment determined by the mode and mechanism of injury, and intraoperative findings.The study was a retrospective analysis of a prospective cohort of patients presenting with terrible triad injuries of the elbow, who underwent surgical treatment between July 2009 and January 2014. All patients were treated surgically according to a modified Pugh standard protocol...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29662775/relationship-between-heterotopic-ossification-and-traumatic-brain-injury-why-severe-traumatic-brain-injury-increases-the-risk-of-heterotopic-ossification
#3
REVIEW
Huan Huang, Wen-Xiang Cheng, Yi-Ping Hu, Jian-Hai Chen, Zheng-Tan Zheng, Peng Zhang
Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone forms in soft tissues. HO involves many predisposing factors, including congenital and postnatal factors. Postnatal HO is usually induced by fracture, burn, neurological damage (brain injury and spinal cord injury) and joint replacement. Recent studies have found that patients who suffered from bone fracture combined with severe traumatic brain injury (S-TBI) are at a significantly increased risk for HO occurrence. Thus, considerable research focused on the influence of S-TBI on fracture healing and bone formation, as well as on the changes in various osteogenic factors with S-TBI occurrence...
January 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662744/postoperative-complications-associated-with-rhbmp2-use-in-posterior-posterolateral-lumbar-fusion
#4
Nabil Esmail, Zorica Buser, Jeremiah R Cohen, Darrel S Brodke, Hans-Joerg Meisel, Jong-Beom Park, Jim A Youssef, Jeffrey C Wang, S Tim Yoon
Study Design: Retrospective database review. Objective: Posterior/posterolateral lumbar fusion (PLF) is an effective treatment for a variety of spinal disorders; however, variations in surgical technique have different complication profiles. The aim of our study was to quantify the frequency of various complications in patients undergoing PLF with and without human recombinant bone morphogenetic protein 2 (rhBMP2). Methods: We queried the orthopedic subset of the Medicare database (PearlDiver) between 2005 and 2011 for patients undergoing PLF procedures with and without rhBMP2...
April 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29655901/in-vivo-heterotopic-culturing-of-prefabricated-tendon-grafts-with-mechanical-stimulation-in-a-sheep-model
#5
M Petri, P Lu, M Omar, M Ettinger, C Krettek, C Neunaber, M Jagodzinski
BACKGROUND: The goal of this study is to investigate the biomechanical and histological properties of in vivo heterotopically prefabricated cruciate ligament replacement grafts with and without mechanical stimulation. The clinical goal is to heterotopically prefabricate a bone-tendon-bone graft for anterior cruciate ligament reconstruction, which allows rapid ingrowth and early full weight bearing. METHODS: In a sheep model, eight quadriceps tendon grafts were harvested and introduced into culture chambers at their proximal and distal ends...
April 11, 2018: Knee
https://www.readbyqxmd.com/read/29652785/clinical-prediction-rule-for-heterotopic-ossification-of-the-hip-in-patients-with-spinal-cord-injury
#6
Eduardo M Suero, Mustafa Citak
STUDY DESIGN: Case-control study; clinical prediction rule. OBJECTIVE: To construct and internally validate a clinical prediction rule to identify patients at high risk of developing heterotopic ossification (HO) after spinal cord injury (SCI). SUMMARY OF BACKGROUND DATA: HO after SCI can lead to loss of joint mobility, loss of function, peripheral nerve entrapment, and pressure sores. HO is usually diagnosed based on clinical symptoms, as no laboratory tests are yet available to identify patients with early HO formation...
April 12, 2018: Spine
https://www.readbyqxmd.com/read/29626545/hypoxia-selective-allosteric-destabilization-of-activin-receptor-like-kinases-a-potential-therapeutic-avenue-for-prophylaxis-of-heterotopic-ossification
#7
Guorong Lu, Mary R Tandang-Silvas, Alyssa C Dawson, Trenton J Dawson, Jay C Groppe
Heterotopic ossification (HO), the pathological extraskeletal formation of bone, can arise from blast injuries, severe burns, orthopedic procedures and gain-of-function mutations in a component of the bone morphogenetic protein (BMP) signaling pathway, the ACVR1/ALK2 receptor serine-threonine (protein) kinase, causative of Fibrodysplasia Ossificans Progressiva (FOP). All three ALKs (-2, -3, -6) that play roles in bone morphogenesis contribute to trauma-induced HO, hence are well-validated pharmacological targets...
April 4, 2018: Bone
https://www.readbyqxmd.com/read/29625813/sidus-stem-free-shoulder-system-for-primary-osteoarthritis-short-term-results-of-a-multicenter-study
#8
Anna Krukenberg, Julie McBirnie, Stefan Bartsch, Nikolaus Böhler, Ernst Wiedemann, Bernhard Jost, Pierre Mansat, Pierre Bellon-Champel, Renzo Angeloni, Markus Scheibel
BACKGROUND: The aim of this prospective multicenter study was to evaluate clinical and radiologic results of a new metaphyseal anchored system. This system features a different anchor geometry that potentially leads to better bony integration and less loosening. METHODS: From November 2012 until December 2015, 148 patients (151 shoulders) were treated with the Sidus Stem-Free Shoulder System at 9 centers in Europe. The main indication was primary osteoarthritis (80...
April 3, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29618652/the-metalloproteinase-proteoglycans-adamts7-and-adamts12-provide-an-innate-tendon-specific-protective-mechanism-against-heterotopic-ossification
#9
Timothy J Mead, Daniel R McCulloch, Jason C Ho, Yaoyao Du, Sheila M Adams, David E Birk, Suneel S Apte
Heterotopic ossification (HO) is a significant clinical problem with incompletely resolved mechanisms. Here, the secreted metalloproteinases ADAMTS7 and ADAMTS12 are shown to comprise a unique proteoglycan class that protects against a tendency toward HO in mouse hindlimb tendons, menisci, and ligaments. Adamts7 and Adamts12 mRNAs were sparsely expressed in murine forelimbs but strongly coexpressed in hindlimb tendons, skeletal muscle, ligaments, and meniscal fibrocartilage. Adamts7-/- Adamts12-/- mice, but not corresponding single-gene mutants, which demonstrated compensatory upregulation of the intact homolog mRNA, developed progressive HO in these tissues after 4 months of age...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29615017/clinical-and-radiographic-outcome-of-dynamic-cervical-implant-dci-arthroplasty-for-degenerative-cervical-disc-disease-a-minimal-five-year-follow-up
#10
Lin-Nan Wang, Bo-Wen Hu, Lei Wang, Yue-Ming Song, Xi Yang, Li-Min Liu, Hao Liu
BACKGROUND: To evaluate the mid- to long-term clinical and radiographic outcomes of anterior cervical discectomy and dynamic cervical implant (DCI) arthroplasty for degenerative cervical disc disease. METHODS: From April 2010 to October 2010, 38 patients with single- or double-level cervical disc herniation underwent anterior cervical discectomy and DCI arthroplasty. The clinical results and radiographic outcomes of these 38 patients (42 levels) were retrospectively evaluated...
April 4, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29614433/acquired-and-congenital-forms-of-heterotopic-ossification-new-pathogenic-insights-and-therapeutic-opportunities
#11
REVIEW
Maurizio Pacifici
Heterotopic ossification (HO) involves the formation and accumulation of extraskeletal bone tissue at the expense of local tissues including muscles and connective tissues. There are common forms of HO that are triggered by extensive trauma, burns and other bodily insults, and there are also rare congenital severe forms of HO that occur in children with Fibrodysplasia Ossificans Progressiva or Progressive Osseous Heteroplasia. Given that HO is often preceded by inflammation, current treatments usually involve anti-inflammatory drugs alone or in combination with local irradiation, but are not very effective...
March 31, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29609970/modified-stoppa-approach-for-operative-treatment-of-acetabular-fractures-10-year-experience-and-mid-term-follow-up
#12
Diederik O Verbeek, Kornelis J Ponsen, Mark van Heijl, J Carel Goslings
INTRODUCTION: The (modified) Stoppa approach for acetabular fracture surgery has gained significant popularity and early results have been encouraging but clinical outcome at extensive follow-up is scarce. The purpose of this study is to provide an update on our experience with this approach for operative treatment of acetabular fractures and to assess clinical outcome at mid-term follow-up. METHODS: In this retrospective study, all patients treated operatively for an acetabular fracture using the Stoppa approach over a 10-year period were included...
March 27, 2018: Injury
https://www.readbyqxmd.com/read/29607763/heterotopic-ossification-following-hip-arthroscopy
#13
Matt Barth, Gilbert M Willett, Kimberly Oliphant
A 21-year-old woman initiated physical therapy 4 days following hip arthroscopic labrum debridement and osteochondroplasty. During postoperative rehabilitation, the patient's status regressed. With persistent symptoms, at 10 weeks postsurgery a computed tomography scan revealed, as confirmed by radiographs, heterotopic ossification development. J Orthop Sports Phys Ther 2018;48(4):344. doi:10.2519/jospt.2018.7420.
April 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29595630/clinical-and-radiographic-outcomes-of-treatment-of-comminuted-mason-type-ii-radial-head-fractures-with-a-new-implant
#14
Yan Shi, Gao-Feng Wang, Kai Mei, Jie Zhang, Chang-Jun Yun, Chen Qian, Jun-Ying Sun
This study aims to evaluate the clinical and radiographic treatment outcomes of comminuted Mason type II radial head fractures, which underwent open reduction and internal fixation (ORIF) using a new implant (mother-child screw, MCS).This study included 16 patients (7 male and 9 female patients; mean age: 40.9 years, age range: 19-68 years), who were treated with ORIF, followed by MCS fixation for comminuted type II radial head fractures. The clinical results were evaluated using the Mayo Elbow Performance Score (MEPS)...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29567209/heterotopic-ossification-the-keys-to-the-kingdom
#15
EDITORIAL
Frederick S Kaplan, Robert J Pignolo, Eileen M Shore
No abstract text is available yet for this article.
April 2018: Bone
https://www.readbyqxmd.com/read/29564614/the-effect-of-late-radiotherapy-on-the-progression-of-heterotopic-ossification-following-total-hip-arthroplasty
#16
Mina Morcos, Karen Smith, Michael Tanzer
INTRODUCTION: Heterotopic ossification (HO) is a known complication after total hip arthroplasty (THA). Radiotherapy is an effective prophylactic treatment for high-risk patients. However, there is no treatment for patients who did not receive prophylactic treatment and subsequently develop HO postoperatively. This study was to determine whether late radiotherapy treatment can prevent the progression of HO following THA. METHODS: A chart review was performed to identify patients who developed HO following THA and were treated with late radiotherapy...
March 21, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29560038/interobserver-reliability-of-radiographic-assessment-after-radial-head-arthroplasty
#17
Rens Bexkens, Femke M A P Claessen, Izaäk F Kodde, Luke S Oh, Denise Eygendaal, Michel P J van den Bekerom
Background: Radiographs are part of routine clinical care after radial head arthroplasty (RHA). Therefore, the aim of this diagnostic study was to assess the interobserver reliability of radiographic assessment following RHA. Methods: Anteroposterior (AP) and lateral radiographs of 24 consecutive patients who underwent press-fit bipolar RHA were evaluated with respect to 14 parameters by 14 orthopaedic surgeons specializing in the elbow: shaft loosening (AP, lateral), subcollar bone resorption, nonbridging heterotopic ossification, capitellar erosion, capitellar osteopenia, implant size, ulnohumeral joint gapping, ulnohumeral joint degeneration, proximal radio-ulnar joint congruency, stem size, stem positioning (AP, lateral) and component dissociation or polyethylene wear of the head with increased angulation...
April 2018: Shoulder & Elbow
https://www.readbyqxmd.com/read/29556212/long-term-consequences-of-traumatic-brain-injury-in-bone-metabolism
#18
REVIEW
Nikita M Bajwa, Chandrasekhar Kesavan, Subburaman Mohan
Traumatic brain injury (TBI) leads to long-term cognitive, behavioral, affective deficits, and increase neurodegenerative diseases. It is only in recent years that there is growing awareness that TBI even in its milder form poses long-term health consequences to not only the brain but to other organ systems. Also, the concept that hormonal signals and neural circuits that originate in the hypothalamus play key roles in regulating skeletal system is gaining recognition based on recent mouse genetic studies. Accordingly, many TBI patients have also presented with hormonal dysfunction, increased skeletal fragility, and increased risk of skeletal diseases...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29554845/sonographic-study-of-repair-gapping-and-tendon-bowstringing-after-primary-flexor-digitorum-profundus-repair-in-zone-2
#19
Lisa Reissner, Nadja Zechmann-Mueller, Holger Jan Klein, Maurizio Calcagni, Thomas Giesen
We report sonographic findings with clinical outcomes after zone 2 flexor digitorum profundus tendon repairs in ten fingers. The tendons underwent a six-strand M-Tang core repair, no circumferential suture, and partial or complete division of the pulleys. Over 12 months after surgery and using ultrasound, we found no gapping at the repair site during finger motion. When the pulleys were divided, there was sonographic evidence of tendon bowstringing, but the bowstringing was minimal. Clinically, we did not find any fingers that displayed tendon bowstringing or had functional loss...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29552484/anatomic-single-incision-repair-of-distal-biceps-tendon-ruptures-using-flexible-reamers
#20
Jimmy Tat, Adam Hart, Adam Cota, Khalid Alsheikh, Dominique Behrends, Paul A Martineau
Distal biceps tendon ruptures are treated operatively in active healthy individuals. Treatment consists of either single- or double-incision techniques, each with its own set of advantages and complications. The double incision was traditionally preferred for a more anatomic reattachment of the distal biceps tendon, but there has been renewed interest in the single-incision anterior approach given its lower risk for heterotopic ossification. However, current single-incision techniques cannot achieve anatomic reconstruction of the distal biceps because of a restricted operational angle with standard rigid instruments...
February 2018: Arthroscopy Techniques
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