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Heterotopic ossification

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https://www.readbyqxmd.com/read/29240012/surgical-treatment-of-chronic-elbow-dislocation-allowing-early-range-of-motion-operative-technique-and-clinical-results
#1
Duane R Anderson, Justin M Haller, Lucas A Anderson, Samuel Hailu, Abebe Chala, Shawn W O'Driscoll
OBJECTIVES: Describe the surgical treatment and patient outcomes of chronic elbow dislocations. DESIGN: Retrospective review SETTING:: Two tertiary referral centers. PATIENTS/PARTICIPANTS: All patients with surgically treated chronic elbow dislocation with no associated articular fracture from January 2009 - January 2015. INTERVENTION: Review of patient demographics, injury chronicity, surgical technique, and patient outcomes...
December 6, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29234663/reconstruction-with-iliac-pedestal-cup-and-proximal-femur-tumor-prosthesis-after-wide-resection-of-chondrosarcoma-10-year-follow-up-results
#2
Diogo Lino Moura, Rúben Fonseca, João Freitas, António Figueiredo, José Casanova
Chondrosarcoma is a malignant cartilage-forming neoplasm. It is difficult to treat because of resistance to both chemotherapy and radiation, making wide local excision the only treatment. This report presents an active, 43 year-old man who was diagnosed with recurrent clear cell chondrosarcoma of the proximal left femur, previously reconstructed with a total hip prosthesis, extending to the weight-bearing dome of the acetabulum. Cancer staging study revealed no signs of tumor dissemination at distance. Given the excellent functional status of the patient, the authors performed a Enneking-Dunham type periacetabular pelvic resection and resected en bloc, with the total hip prosthesis including 22 cm of the femur and a portion of the hip abductor apparatus...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29230632/ghrelin-accelerates-the-cartilagic-differentiation-of-rabbit-mesenchymal-stem-cells-through-the-erk1-2-pathway
#3
Nan Ye, Lin Wang, Zhe Dou, Jian Huang
Mesenchymal stem cells (MSCs) can differentiate into chondroblasts, adipocytes, or cartilage under appropriate stimulation. Identifying a mechanism triggering the differentiation of MSCs into cartilage may help develop novel therapeutic approaches for treating heterotopic ossification, the pathological formation of lamellar bone in soft tissue outside the skeleton that can lead to debilitating immobility. Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, stimulates growth hormone secretion, and has both orexigenic and adipogenic effects...
December 12, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29229348/bone-morphogenetic-proteins-usage-in-anterior-lumbar-inter-body-fusion-what-else-can-go-wrong
#4
Elias Elias, Zeina Nasser, Lona Winegan, Terence Verla, Ibrahim Omeis
BACKGROUND: Bone Morphogenetic Protein (BMP) graft showed promising outcome during early phases of its use. However unreported adverse events and off label use shattered its safe profile and raised concerns regarding its indication. In 2008, the Food and Drug Administration (FDA) prohibited its use in anterior cervical spine procedures due to possibility of edema, hematoma and need of intubation. At the molecular level, BMP act as multifactorial growth factors playing a role in cartilage, heart, and bone formation...
December 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29227562/crosstalk-between-substance-p-and-calcitonin-gene-related-peptide-during-heterotopic-ossification-in-murine-achilles-tendon
#5
Ceren Tuzmen, Kostas Verdelis, Lee Weiss, Phil Campbell
Heterotopic ossification (HO) is abnormal bone formation within soft tissue, usually predisposed by neurogenic or musculoskeletal trauma. Inflammation resulting from trauma is considered to be the main trigger for HO by eliciting changes within the injury site, including elevation of bone morphogenetic proteins (BMPs). Recent research, however, has also associated changes in sensory neuropeptide expression with HO. Substance P (SP) and calcitonin gene-related peptide (CGRP) are two of those neuropeptides that have been implicated with various aspects of HO, including regulation of inflammation and BMP signaling...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29225159/histopathology-of-periarticular-non-hereditary-heterotopic-ossification
#6
REVIEW
Kristin L Foley, Nader Hebela, Mary Ann Keenan, Robert J Pignolo
In the mature adult skeleton, new bone formation is normally restricted to regeneration of osseous tissue at sites of fracture. However, heterotopic ossification, or the formation of bone outside the normal skeleton, can occur within muscle, adipose, or fibrous connective tissue. Periarticular non-hereditary heterotopic ossification (NHHO) may occur after musculoskeletal trauma, following CNS injury, with certain arthropathies, or following injury or surgery that is often sustained in the context of age-related pathology...
December 7, 2017: Bone
https://www.readbyqxmd.com/read/29220729/comparison-of-dynamic-cervical-implant-versus-anterior-cervical-discectomy-and-fusion-for-the-treatment-of-single-level-cervical-degenerative-disc-disease-a-five-year-follow-up
#7
Ce Zhu, Xi Yang, Lei Wang, Bo-Wen Hu, Li-Min Liu, Lin-Nan Wang, Hao Liu, Yue-Ming Song
OBJECTIVE: To compare clinical and radiographic outcomes of dynamic cervical implant(DCI) with anterior cervical discectomy and fusion(ACDF) in the treatment of single-level cervical degenerative disc disease (CDDD) 5 years after surgery. PATIENTS AND METHODS: Forty-three patients with DCI were matched one-to-one with patients with ACDF based on age, gender, and operative segment in this retrospective study. All patients had been followed up for more than 5 years...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29216503/clinical-and-radiographic-comparison-of-cervical-disc-arthroplasty-with-prestige-lp-disc-and-anterior-cervical-fusion-a-minimum-6-year-follow-up-study
#8
Junfeng Zeng, Hao Liu, Beiyu Wang, Yuxiao Deng, Chen Ding, Hua Chen, Yi Yang, Ying Hong, Ning Ning
OBJECTIVES: To retrospectively compare the long-term clinical and radiographic outcomes of cervical disc arthroplasty (CDA) with Prestige-LP Disc and anterior cervical discectomy and fusion (ACDF) for single-level cervical degenerative disc disease. PATIENTS AND METHODS: Ninety-eight patients (45 CDA and 53 ACDF) with a minimum 6-year follow-up were included. Clinical evaluations included Japanese Orthopedic Association (JOA), visual analogue scale (VAS), and Neck Disability Index (NDI) scores...
December 4, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29200484/treatment-of-femoroacetabular-impingement-with-a-mini-open-direct-anterior-approach
#9
Paweł Skowronek, Marek Synder, Michał Polguj, Dariusz Marczak, Marcin Sibiński
Background: The opinion about best methods of femoroacetabular impingement (FAI) treatment are not consistent. Operative treatment of this condition may be arthroscopic, but open procedures with osteotomy of the greater trochanter and hip dislocation has been used. The present study evaluates the benefits of the mini-open direct anterior approach (DAA) in treating patients with FAI, with is a procedure available for most orthopedic surgeons. Materials and Methods: 39 patients treated for FAI (25 men and 14 women) at an average age of 29...
November 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29195898/outcomes-of-displaced-olecranon-fractures-treated-with-the-olecranon-sled
#10
Andrew J Lovy, Isaiah Levy, Aakash Keswani, Todd Rubin, Michael R Hausman
BACKGROUND: Tension-band wiring is largely considered the gold standard for fixation of displaced olecranon fractures despite high rates of hardware complications. The purpose of this study was to report the outcomes of displaced olecranon fractures treated with the Olecranon Sled. METHODS: We retrospectively reviewed all displaced olecranon fractures from 2011-2015 treated with the Olecranon Sled. Inclusion was limited to functionally independent patients with Mayo type II fractures and minimum 12-month follow-up...
November 28, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29195812/effects-of-a-single-condylar-neck-fracture-without-condylar-cartilage-injury-on-traumatic-heterotopic-ossification-around-the-temporomandibular-joint-in-mice
#11
Ningjuan Ouyang, Xiaofang Zhu, Hongliang Li, Yuheng Lin, Jun Shi, Jiewen Dai, Guofang Shen
OBJECTIVES: In this study, we tried to explore the effects of a single condylar neck fracture without condylar cartilage injury during the pathogenesis process of traumatic heterotopic ossification around the temporomandibular joint (THO-TMJ). STUDY DESIGN: One-month-old C57 BL/6 J male mice were divided into 2 groups. In group 1, condylar cartilage was partially removed in the right joint to induce THO. In group 2, a single fracture on the condylar neck was created using small scissors...
November 6, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29193256/post-traumatic-heterotopic-ossification-an-old-problem-in-need-of-new-solutions
#12
REVIEW
Neil Eisenstein, Sarah Stapley, Liam Grover
Heterotopic ossification (HO) is the formation of pathological bone in ectopic sites and it can have serious consequences for functional outcomes. For many years, its main clinical relevance was as a rare complication of elective joint arthroplasty or CNS injury and a number of prophylaxes were developed to mitigate against it in these settings. As a consequence of changes in patterns of wounding and survival in conflicts since the turn of the century, post-traumatic HO has become much more common and case severity has increased...
November 29, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29192736/operative-findings-and-complications-associated-with-adjunctive-hip-arthroscopy-in-95-hips-undergoing-periacetabular-osteotomy
#13
Gregory Maxwell Gosey, Michael P Muldoon, Robert M Healey, Richard F Santore
PURPOSE: to report our initial experience with adjunctive hip arthroscopy and periacetabular osteotomy (PAO). METHODS: Retrospective review of patients who underwent PAO and ipsilateral hip arthroscopy between 2003 and 2013. Indications for arthroscopy were mechanical symptoms and/or positive magnetic resonance imaging to suggest intra-articular pathology including chondrolabral lesions, ligamentum teres tears and hypertrophy, and synovitis. Preoperative Tönnis arthritis grades, age, sex, operative findings and treatment, complications, and, if available, hip survival were recorded...
December 1, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29191669/incidence-and-factors-associated-with-development-of-heterotopic-ossification-after-damage-control-laparotomy
#14
Yifan Wang, Agatha Stanek, Jeremy Grushka, Paola Fata, Andrew Beckett, Kosar Khwaja, Tarek Razek, Dan L Deckelbaum
INTRODUCTION: The incidence of heterotopic ossification (HO) following damage control laparotomy (DCL) is unknown. Abdominal wall reconstruction may prove more challenging in patients with HO. This study examines the incidence and factors associated with HO in patients with an open abdomen following DCL. METHODS: A retrospective review of all patients with an open abdomen after DCL at a level 1 trauma centre from 2009 to 2015 was conducted. Demographics and peri-operative outcomes of patients with and without HO were compared...
November 26, 2017: Injury
https://www.readbyqxmd.com/read/29187475/reliable-radiation-technique-to-minimize-ovarian-dose-during-radiation-prophylaxis-of-heterotopic-ossification
#15
Waleed F Mourad, Satyaseelan Packianathan, Weisi Yan, Mahboubeh Pishgou, John K Ma, Sherif G Shaaban, Edward M Marchan, Rui He, Paul N Mobit, Chunli Claus Yang, Srinivasan Vijayakumar
BACKGROUND/AIM: Scattered radiation during radiotherapy (RT) directed at the hip joint poses concerns about ovarian function in patients of reproductive age. Here, we report the impact of using a split-beam technique (SBT) and different photon energies on the total ovary dose during radiation prophylaxis of heterotopic ossification (HO). PATIENTS AND METHODS: This was a single-institution, retrospective study of 32-patients with traumatic acetabular fractures (TAF)...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29175272/fibrodysplasia-ossificans-progressiva-in-china
#16
REVIEW
Dunmin She, Keqin Zhang
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare and devastating disorder characterized by cumulative episodes of progressive heterotopic ossification. It is estimated that there exist 600-700 patients in Mainland China. Nevertheless, due to the rarity, many FOP patients were initially misdiagnosed. Until now fewer than 150 patients have been identified in Mainland China. This review summarizes the epidemiology and clinical features of FOP patients, the progress of clinical and basic research in China, and the future of FOP care in China...
November 21, 2017: Bone
https://www.readbyqxmd.com/read/29174871/resection-of-neurogenic-heterotopic-ossification-nho-of-the-hip
#17
REVIEW
P Denormandie, N de l'Escalopier, L Gatin, A Grelier, F Genêt
Neurogenic heterotopic ossification of the hip is secondary to neurologic lesions such as cranial trauma, stroke, medullary injury or cerebral anoxia. We shall not deal here with the other etiologies of heterotopic ossification. There are numerous locations within the hip, depending on etiology, and relations with adjacent neurovascular structures are sometimes close. Preoperative work-up should include contrast-enhanced CT; scintigraphy is non-contributive. Indications for surgery are decided in a multidisciplinary team meeting, with a contract laying out expected functional gain...
November 22, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29170109/activin-a-amplifies-dysregulated-bmp-signaling-and-induces-chondro-osseous-differentiation-of-primary-connective-tissue-progenitor-cells-in-patients-with-fibrodysplasia-ossificans-progressiva-fop
#18
REVIEW
Haitao Wang, Eileen M Shore, Robert J Pignolo, Frederick S Kaplan
BACKGROUND: Fibrodysplasia ossificans progressiva (FOP), is caused by mutations in the type I BMP receptor ACVR1 that lead to increased activation of the BMP-pSmad1/5/8 signaling pathway. Recent findings suggest that Activin A (Act A) promiscuously stimulates the bone morphogenetic protein (BMP) signaling pathway in vitro and mediates heterotopic ossification (HO) in mouse models of FOP, but primary data from FOP patient cells are lacking. OBJECTIVE: To examine BMP-pSmad1/5/8 pathway signaling and chondro-osseous differentiation in response to endogenous and exogenous Act A in primary connective tissue progenitor cells [CTPCs; also known as stem cells from human exfoliated deciduous teeth (SHED) cells] from patients with FOP...
November 20, 2017: Bone
https://www.readbyqxmd.com/read/29162246/floating-hip-and-associated-injuries
#19
Plácido Zamora-Navas, Francisco Javier Estades-Rubio, Juan Ramón Cano, Enrique Guerado
AIM: To describe our experience in treating patients diagnosed with floating hip injury and to communicate the outcomes achieved and the rate of complications. A secondary aim is to compare the results of this group in terms of quality of life with those of patients presenting with a fracture either of the pelvis or of the acetabulum, but in which the femoral segment is not involved. PATIENTS AND METHODS: This is a descriptive study of the patients diagnosed with floating hip injury (25 patients) who were treated at our hospital between 2004 and 2007, with a minimum follow-up of seven years...
November 2017: Injury
https://www.readbyqxmd.com/read/29156902/symptomatic-palliation-with-radiotherapy-in-extensive-heterotopic-ossifications
#20
Mary Jiayi Tao, Linda Probyn, Michael Poon, Hans Kreder, Bo Angela Wan, Patrick Diaz, Edward Chow
Heterotopic ossification (HTO) is the dystrophic formation of mature lamellar bone outside the confines of normal osseous tissues. It is frequently a complication which occurs following traumatic insult, both iatrogenic and non-iatrogenic, and neurological compromise. While mild degree of disease is often asymptomatic, significant pain and mobility limitations may result in reduced quality of life in advanced cases. Currently, the commonly accepted management for patients experiencing significant symptomatic HTOs is a combination therapy of surgical excision with prophylactic radiotherapy in the immediate perioperative period...
September 12, 2017: Annals of Palliative Medicine
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