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Heterotopic ossification

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https://www.readbyqxmd.com/read/28526267/neurological-heterotopic-ossification-current-understanding-and-future-directions
#1
Rhys D Brady, Sandy R Shultz, Stuart J McDonald, Terence J O'Brien
Neurological heterotopic ossification (NHO) involves the formation of bone in soft tissue following a neurological condition, of which the most common are brain and spinal cord injuries. NHO often forms around the hip, knee and shoulder joints, causing severe pain and joint deformation which is associated with significant morbidity and reduced quality of life. The cellular and molecular events that initiate NHO have been the focus of an increasing number of human and animal studies over the past decade, with this work largely driven by the need to unearth potential therapeutic interventions to prevent the formation of NHO...
May 16, 2017: Bone
https://www.readbyqxmd.com/read/28525482/artificial-cervical-disk-replacement-for-the-treatment-of-adjacent-segment-disease-after-anterior-cervical-decompression-and-fusion
#2
Sheng Bin, Huang Xiangwang, Xiao Sheng, Xiang Tiecheng, Liu Xiangyang, Zhang Yi, Liu Bin
STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate the outcome of artificial cervical disk replacement (ACDR) for the treatment of adjacent segment disease (ASD) after anterior cervical decompression and fusion (ACDF). SUMMARY OF BACKGROUND DATA: ACDF is the useful procedure for degenerative cervical diseases. However, studies have reported accelerated degeneration of functional spinal units adjacent to the fusion site after ACDF. MATERIALS AND METHODS: Between January 2004 and January 2011, 32 inpatients (18 male, 14 female; age, 38-61 y; mean, 48 y) underwent ACDR for the treatment of ASD after previous ACDF (single-level: n=12; 2-level: n=15; 3-level: n=5)...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28507884/a-retrospective-analysis-of-complications-associated-with-bone-morphogenetic-protein-2-in-anterior-lumbar-interbody-fusion
#3
Kevork Hindoyan, Justin Tilan, Zorica Buser, Jeremiah R Cohen, Darrel S Brodke, Jim A Youssef, Jong-Beom Park, S Tim Yoon, Hans-Joerg Meisel, Jeffrey C Wang
STUDY DESIGN: Retrospective review. OBJECTIVE: The aim of our study was to quantify the frequency of complications associated with recombinant human bone morphogenetic protein 2 (rhBMP-2) use in anterior lumbar interbody fusion (ALIF). METHODS: The orthopedic subset of the Medicare database (PearlDiver) was queried for this retrospective cohort study using International Statistical Classification of Diseases 9 (ICD-9) and Current Procedure Terminology (CPT) codes for ALIF procedures with and without rhBMP-2 between 2005 and 2010...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28506299/developmental-hip-dysplasia-treated-by-total-hip-arthroplasty-using-a-cementless-wagner-cone-stem-in-young-adult-patients-with-a-small-physique
#4
Ping Zhen, Jun Liu, Hao Lu, Hui Chen, Xusheng Li, Shenghu Zhou
BACKGROUND: Developmental hip dysplasia (DDH) may lead to severe acetabular and femoral abnormalities that can render total hip arthroplasty (THA) challenging, especially in DDH patients with a small physique. Most conventional cemented or cementless femoral components are often difficult to implant in the narrow femoral canal and require slight version correction during surgery. The aim of this study was to present the mid-term results of THA in the treatment of DDH patients with a small physique using a cementless Wagner cone prosthesis (Zimmer®, US)...
May 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28500495/causes-for-early-and-late-surgical-re-intervention-after-radial-head-arthroplasty
#5
Pierre Laumonerie, David Ancelin, Nicolas Reina, Meagan E Tibbo, Panagiotis Kerezoudis, Stephanie Delclaux, Nicolas Bonnevialle, Pierre Mansat
PURPOSE: The primary objective was to describe the reasons for surgical re-intervention after radial head arthroplasty. The secondary objective was to analyze the radiographic and clinical outcomes after surgical re-intervention at the elbow with implant conservation. METHODS: Among the 70 radial head arthroplasties with bipolar radial head implant performed between 2002 and 2014, 29 required surgical re-interventions. Reasons for surgical re-intervention were gathered from operative notes and follow-up documentation...
May 12, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28500436/the-efficacy-of-a-multimodal-analgesia-protocol-in-preventing-heterotopic-ossification-after-acetabular-fractures-surgery
#6
Liang Cheng, Hai-Tao Long, Bu-Hua Sun, Shu-Shan Zhao, Yong Zhu
Background Heterotopic ossification (HO) after joint surgery is always a disturbing problem for patients and surgeons. Prophylaxis is the most effective therapy. Objective To assess the efficacy and safety of a multimodal analgesia protocol that included parecoxib and celecoxib in preventing HO after acetabular fracture surgery. Setting Selecting patients from trauma registry of our hospital. Method We identified 259 patients who had acetabular fracture surgery between January 2008 and December 2014. Hundredsixty-three patients received parecoxib and celecoxib (Group A) and 96 patients received no prophylaxis (Group B)...
May 12, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28484423/evaluation-of-salivary-cytokines-for-diagnosis-of-both-trauma-induced-and-genetic-heterotopic-ossification
#7
Hsiao Hsin Sung Hsieh, Michael T Chung, Ronald M Allen, Kavitha Ranganathan, Joe Habbouche, David Cholok, Jonathan Butts, Arminder Kaura, Ramkumar Tiruvannamalai-Annamalai, Chris Breuler, Caitlin Priest, Shawn J Loder, John Li, Shuli Li, Jan Stegemann, Steven L Kunkel, Benjamin Levi
PURPOSE: Heterotopic ossification (HO) occurs in the setting of persistent systemic inflammation. The identification of reliable biomarkers can serve as an early diagnostic tool for HO, especially given the current lack of effective treatment strategies. Although serum biomarkers have great utility, they can be inappropriate or ineffective in traumatic acute injuries and in patients with fibrodysplasia ossificans progressiva (FOP). Therefore, the goal of this study is to profile the cytokines associated with HO using a different non-invasive source of biomarkers...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28481386/early-versus-late-weight-bearing-protocols-for-surgically-managed-posterior-wall-acetabular-fractures
#8
Austin Heare, Nicholas Kramer, Christopher Salib, Cyril Mauffrey
Despite overall improved outcomes with open reduction and internal fixation of acetabular fractures, posterior wall fractures show disproportionately poor results. The effect of weight bearing on outcomes of fracture management has been investigated in many lower extremity fractures, but evidence-based recommendations in posterior wall acetabular fractures are lacking. The authors systematically reviewed the current literature to determine if a difference in outcome exists between early and late postoperative weight-bearing protocols for surgically managed posterior wall acetabular fractures...
May 8, 2017: Orthopedics
https://www.readbyqxmd.com/read/28472996/a-survey-of-proteomic-biomarkers-for-heterotopic-ossification-in-blood-serum
#9
Laura E Edsberg, Erin L Crowgey, Patrick M Osborn, Jennifer T Wyffels
BACKGROUND: Heterotopic ossification (HO) is a significant problem for wounded warriors surviving high-energy blast injuries; however, currently, there is no biomarker panel capable of globally characterizing, diagnosing, and monitoring HO progression. The aim of this study was to identify biomarkers for HO using proteomic techniques and blood serum. METHODS: Isobaric tags for relative and absolute quantitation (iTRAQ) was used to generate a semi-quantitative global proteomics survey of serum from patients with and without heterotopic ossification...
May 4, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28466104/imaging-evaluation-of-the-hip-after-arthroscopic-surgery-for-femoroacetabular-impingement
#10
REVIEW
Julia Crim
Arthroscopic surgery for femoroacetabular impingement (FAI) is increasingly frequently performed. Initial reports were that complications were very low, but as experience has increased, a number of long-term complications, in addition to factors related to poor clinical outcomes, have been identified. This review describes the normal and abnormal postoperative imaging appearance of the hip after arthroscopy for FAI. Abnormalities discussed include incomplete resection or over-resection of the impingement lesion, heterotopic ossification, cartilage damage, chondrolysis, instability and dislocation, recurrent labral tear, adhesions, psoas atrophy, infection, and avascular necrosis...
May 2, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28465250/a-cumulative-analogue-joint-involvement-scale-cajis-for-fibrodysplasia-ossificans-progressiva-fop
#11
Frederick S Kaplan, Mona Al Mukaddam, Robert J Pignolo
BACKGROUND: Fibrodysplasia ossificans progressiva (FOP) is a catastrophic genetic disorder of progressive heterotopic ossification (HO). Assessment of functional mobility in FOP will be essential to support clinical trials of investigational agents. RESULTS: Of necessity, we developed a simple, rapidly-administered, cumulative analogue joint involvement scale (CAJIS) for FOP based on assessments in 144 individuals worldwide with classic FOP. CONCLUSIONS: CAJIS scores correlated with patient age, activities of daily living, and ambulatory function with excellent inter-rater variability...
April 29, 2017: Bone
https://www.readbyqxmd.com/read/28461963/distal-biceps-tendon-injuries-a-clinically-relevant-current-concepts-review
#12
Eduard Alentorn-Geli, Andrew T Assenmacher, Joaquín Sánchez-Sotelo
Distal biceps tendon (DBT) conditions comprise a spectrum of disorders including bicipitoradial bursitis, partial tears, acute and chronic complete tears.In low-demand patients with complete DBT tears, non-operative treatment may be entertained provided the patient understands the potential for residual weakness, particularly in forearm supination.Most acute tears are best treated by primary repair using either single-incision or double-incision techniques with good clinical outcomes.Single-incision techniques may carry a higher risk of nerve-related complications, whereas double-incision techniques have historically been considered to carry a higher risk of heterotopic ossification, particularly if the ulna is exposed...
September 2016: EFORT Open Rev
https://www.readbyqxmd.com/read/28460412/mir-615-3p-inhibits-the-osteogenic-differentiation-of-human-lumbar-ligamentum-flavum-cells-via-suppression-of-osteogenic-regulators-gdf5-and-foxo1
#13
Jichao Yin, Guihua Zhuang, Yi Zhu, Xinglv Hu, Hongmou Zhao, Rongqiang Zhang, Hao Guo, Xiaochen Fan, Yi Cao
Ossification of the ligamentum flavum (OLF) is a disease of heterotopic ossification in spinal ligaments. The key of the OLF pathogenesis is the differentiation of fibroblasts into osteoblasts. In this study, we explored the role of miR-615-3p in the osteogenic differentiation of human LF cells. The expression of miR-615-3p was detected during the osteogenic differentiation of hFOB1.19 human osteoblasts, human BMSCs and human LF cells. The qPCR results showed that miR-615-3p was being decreased during the osteogenic differentiation of these cell lineages...
April 29, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28456672/muscle-localization-of-heterotopic-ossification-following-spinal-cord-injury
#14
Malte Ohlmeier, Eduardo M Suero, Mirko Aach, Renate Meindl, Thomas A Schildhauer, Mustafa Citak
BACKGROUND: Heterotopic Ossification (HO) is a known complication especially in people suffering traumatic spinal cord injury (SCI). Though some risk factors have already been described, the pathophysiology of HO is still unknown. The pelvis is the most common region for HO occurrence. However, the prevalence of HO by muscle groups about the hip is not well described. PURPOSE: To analyze the prevalence of early HO in muscle groups about the hip in 267 patients with SCI...
April 26, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28455214/conserved-signaling-pathways-underlying-heterotopic-ossification
#15
Chen Kan, Lijun Chen, Yangyang Hu, Na Ding, Haimei Lu, Yuyun Li, John A Kessler, Lixin Kan
Heterotopic ossification (HO), a serious disorder of extra-skeletal bone formation, occurs as a common complication of trauma or in rare genetic disorders. Many conserved signaling pathways have been implicated in HO; however, the exact underlying molecular mechanisms for many forms of HO are still unclear. The emerging picture is that dysregulation of bone morphogenetic protein (BMP) signaling plays a central role in the process, but that other conserved signaling pathways, such as Hedgehog (HH), Wnt/β-catenin and Fibroblast growth factors (FGF), are also involved, either through cross-talk with BMP signaling or through other independent mechanisms...
April 25, 2017: Bone
https://www.readbyqxmd.com/read/28453354/heterotopic-ossification-after-the-arthroscopic-treatment-of-lateral-epicondylitis
#16
Mihir J Desai, Hari Ramalingam, David S Ruch
BACKGROUND: Heterotopic ossification (HO) is a well-known complication following the surgical treatment of fractures and dislocations about the elbow but it is not commonly discussed as a complication following arthroscopy. We present a case of a young athlete who developed HO after the arthroscopic treatment of lateral epicondylitis. METHODS: This is a case report chart review of a 24 year old male with lateral epicondylitis. After failing conservative measures, arthroscopic debridement of the extensor carpi radialis brevis (ECRB) origin ensued...
May 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28451497/evaluation-of-adverse-events-in-total-disc-replacement-a-meta-analysis-of-fda-summary-of-safety-and-effectiveness-data
#17
Paul A Anderson, Ahmad Nassr, Bradford L Currier, Arjun S Sebastian, Paul M Arnold, Michael G Fehlings, Thomas E Mroz, K Daniel Riew
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVES: The safety of new technology such as cervical total disc replacement (TDR) is of paramount importance and is best evaluated in randomized clinical trials (RCT). We compared complication risks of TDR to fusion using data from Investigational Device Exemptions. METHODS: A systematic review of FDA Summary of Safety and Effectiveness reports of the 8 approved cervical TDRs was performed...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28446184/results-of-167-consecutive-cases-of-acetabular-fractures-using-the-kocher-langenbeck-approach-a-case-series
#18
Lukas L Negrin, David Seligson
BACKGROUND: Acetabular fractures are quite challenging injuries for the orthopedic surgeon because of their low incidence and their deep and complex anatomy. The objective of this study was to evaluate surgeon-independent parameters that might influence radiographic outcome and early complication rates of high-energy acetabular fractures treated by open reduction and internal fixation via the Kocher-Langenbeck approach, the golden standard for posterior access. METHODS: One hundred sixty-seven consecutive patients (111 males and 56 females) with a mean age of 41...
April 26, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28444541/reverse-shoulder-arthroplasty-for-massive-irreparable-rotator-cuff-tears-and-cuff-tear-arthropathy-a-systematic-review
#19
REVIEW
S Petrillo, U G Longo, R Papalia, V Denaro
PURPOSE: To report the outcomes and complications of reverse shoulder arthroplasty (RSA) in massive irreparable rotator cuff tears (MIRCT) and cuff tear arthropathy (CTA). METHODS: A systematic review of the literature contained in Medline, Cochrane, EMBASE, Google Scholar and Ovid databases was conducted on May 1, 2016, according to PRISMA guidelines. The key words "reverse total shoulder arthroplasty" or "reverse total shoulder prostheses" with "rotator cuff tears"; "failed rotator cuff surgery"; "massive rotator cuff tears"; "irreparable rotator cuff tears"; "cuff tear arthropathy"; "outcomes"; "complications" were matched...
April 25, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28438880/testicular-dose-during-prophylaxis-of-heterotopic-ossification-with-radiation-therapy
#20
Waleed F Mourad, John K Ma, Satyaseelan Packianathan, Weisi Yan, Sherif G Shaaban, Edward M Marchan, Lamiaa E Abdallah, Rei He, Paul N Mobit, Chunli Claus Yang, Srinivasan Vijayakumar
AIM: A single-institution, retrospective study was performed to investigate potential techniques to minimize radiation exposure to the testicles during heterotopic ossification (HO) prophylaxis. We report the impact of split-beam technique (SBT) and different photon energies on the total dose of radiation received by the testicles during prophylaxis of HO. MATERIALS AND METHODS: Between 2008 and 2010, we identified 64 patients with traumatic acetabular fractures who underwent surgery followed by radiation therapy (RT) without testicular shielding...
May 2017: In Vivo
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