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https://www.readbyqxmd.com/read/29684181/efficacy-and-safety-of-surgery-for-mild-degenerative-cervical-myelopathy-results-of-the-aospine-north-america-and-international-prospective-multicenter-studies
#1
Jetan H Badhiwala, Christopher D Witiw, Farshad Nassiri, Muhammad A Akbar, Alireza Mansouri, Jefferson R Wilson, Michael G Fehlings
BACKGROUND: There is controversy over the optimal treatment strategy for patients with mild degenerative cervical myelopathy (DCM). OBJECTIVE: To evaluate the degree of impairment in baseline quality of life as compared to population norms, as well as functional, disability, and quality of life outcomes following surgery in a prospective cohort of mild DCM patients undergoing surgical decompression. METHODS: We identified patients with mild DCM (modified Japanese Orthopaedic Association [mJOA] 15 to 17) enrolled in the prospective, multicenter AOSpine CSM-NA or CSM-I trials...
April 19, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29684103/common-mental-disorders-and-work
#2
Paul J Nicholson
Background: Governments and employers' organizations have sustained focus on common mental disorders (CMD), how they impact a person's ability to gain or continue work, the costs of sickness absence, presenteeism and job loss, and the positive impact of work on wellbeing. Sources of data: Scientific literature, mainly systematic reviews and grey literature, i.e. publications not accessible through medical databases. Areas of agreement: CMD are a major cause of disability, unemployment and dependency on welfare benefits...
April 19, 2018: British Medical Bulletin
https://www.readbyqxmd.com/read/29682005/global-burden-of-mental-disorders-among-children-aged-5-14-years
#3
Marie Laure Baranne, Bruno Falissard
Background: The global burden of disease (GBD) study provides information about fatal and non-fatal health outcomes around the world. Methods: The objective of this work is to describe the burden of mental disorders among children aged 5-14 years in each of the six regions of the World Health Organisation. Data come from the GBD 2015 study. Outcomes: disability-adjusted life-years (DALYs) are the main indicator of GBD studies and are built from years of life lost (YLLs) and years of life lived with disability (YLDs)...
2018: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/29681082/worries-and-needs-of-adults-and-parents-of-adults-with-neurofibromatosis-type-1
#4
Andre B Rietman, Hanneke van Helden, Pauline H Both, Walter Taal, Jeroen S Legerstee, AnneLoes van Staa, Henriette A Moll, Rianne Oostenbrink, Agnies M van Eeghen
Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder associated with lifelong tumor growth propensity and neurocognitive impairments. Although follow-up of adults with NF1 often focuses on tumor growth, follow-up of cognitive or social problems and other NF1-related comorbidity is often not a part of standardized care. In order to provide optimal care services for these patients, we explored the care needs of adults with NF1. A qualitative study was performed using semi-structured group interviews, exploring worries and care needs in medical, psychological, and socioeconomic domains, also focusing on the transition from pediatric to adult care...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29680774/targeting-hypothalamic-pituitary-adrenal-axis-hormones-and-sex-steroids-for-improving-cognition-in-major-mood-disorders-and-schizophrenia-a-systematic-review-and-narrative-synthesis
#5
REVIEW
Virginia Soria, Alexandre González-Rodríguez, Elena Huerta-Ramos, Judith Usall, Jesús Cobo, Miquel Bioque, Juan David Barbero, Clemente García-Rizo, Meritxell Tost, José Antonio Monreal, Javier Labad
Cognitive deficits are a core feature of serious mental illnesses such as schizophrenia, major depressive disorder (MDD) and bipolar disorder (BD) and are a common cause of functional disability. There is limited efficacy of pharmacological interventions for improving the cognitive deficits in these disorders. As pro-cognitive pharmacological treatments are lacking, hormones or drugs that target the endocrine system may become potential candidates for 'repurposing' trials aiming to improve cognition. We aimed to study whether treatment with drugs targeting the hypothalamic-pituitary-adrenal (HPA) axis and sex steroids can improve cognition in patients with schizophrenia, MDD or BD...
April 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29680191/-cost-of-hypertrophy-due-to-intrauterine-growth-restriction-attributable-to-air-pollution-in-france
#6
C Rafenberg, I Annesi-Maesano
Exposure of pregnant women to fine particulate matter<2.5μm in diameter (PM2.5 ) is responsible for low birthweight (LBW) and intellectual disabilities, as expressed by a lower intelligence quotient (IQ). We estimated the attributable cost due to PM2.5 of healthcare at birth and cognitive retardation of children with LBW in metropolitan France in 2012. The cost of specific care of the 8300 (range, 3100-13,300) children born every year in France with a LBW attributable to PM2.5 exposure is estimated at €25 million (range, € 9...
April 18, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29678183/a-randomized-controlled-cross-over-trial-investigating-the-effect-of-anti-inflammatory-diet-on-disease-activity-and-quality-of-life-in-rheumatoid-arthritis-the-anti-inflammatory-diet-in-rheumatoid-arthritis-adira-study-protocol
#7
Anna Winkvist, Linnea Bärebring, Inger Gjertsson, Lars Ellegård, Helen M Lindqvist
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects 0.5-1.0% of the population, and where many patients in spite of modern pharmacological treatment fail to reach remission. This affects physical as well as mental wellbeing and leads to severely reduced quality of life and reduced work capacity, thus yielding high individual as well as societal costs. As a complement to modern pharmacological treatment, lifestyle intervention should be evaluated as a treatment option...
April 20, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29678126/associations-of-depression-anxiety-and-ptsd-with-neurological-disability-and-cognitive-impairment-in-survivors-of-moyamoya-disease
#8
Chanchan Liu, Xiyan Yi, Ting Li, Lei Xu, Mei Hu, Suming Zhang, Rifeng Jiang
Depression, anxiety and posttraumatic stress disorder (PTSD) are common complications of cerebrovascular diseases. However, they were seldom explored in Moyamoya Disease (MMD) survivors. In this study, we measured the prevalence of depression, anxiety and PTSD in MMD survivors. We evaluated the association of mental disorders with neurological disability and cognitive impairment, and further find out the independent protective and risk factors of neurological disability and cognitive impairment. In MMD survivors, the prevalence of these three mental disorders is high, 46...
April 20, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29674367/trends-in-diagnosis-specific-work-disability-before-and-after-ischaemic-heart-disease-a-nationwide-population-based-cohort-study-in-sweden
#9
Jenni Ervasti, Marianna Virtanen, Tea Lallukka, Emilie Friberg, Ellenor Mittendorfer-Rutz, Erik Lundström, Kristina Alexanderson
OBJECTIVES: We examined trends of diagnosis-specific work disability before and after ischaemic heart disease (IHD). DESIGN: Participants were followed 4 years before and 4 years after an IHD event for diagnosis-specific work disability (sickness absence and disability pension). SETTING AND PARTICIPANTS: A Swedish population-based cohort study using register data on all individuals aged 25-60 years, living in Sweden, and who suffered their first IHD event in 2006-2008 (n=23 971) was conducted...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29674240/the-impact-of-antipsychotics-as-a-risk-factor-for-thromboembolism
#10
REVIEW
Ewa A Ogłodek, Marek J Just, Anna D Grzesińska, Aleksander Araszkiewicz, Adam R Szromek
Patients with schizophrenia are predisposed toward developing cardiovascular disease. Although neuroleptics affect the cardiovascular system, it is also important to consider the consequences of the disease itself such as lower physical activity due to living on disability pension, inadequate nutrition, and/or nicotine addiction, being more common among patients with schizophrenia versus the general population. All these factors combined lead to an increased risk of death caused by cardiovascular conditions in schizophrenic patients...
December 15, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29673269/dual-diagnosis-a-problematic-construct-when-applied-to-persons-with-intellectual-disabilities
#11
John D McLennan
The term dual diagnosis can refer to the co-occurrence of an intellectual disability and a mental disorder. While such a term may have some advocacy rationale aimed at facilitating improved mental health care for those with intellectual disabilities, it is proposed that the construct has flawed underpinnings, and its application may problematize mental health service delivery. A core concern is the promotion of categorical diagnostic models, whereas dimensional models may more accurately reflect underlying continuums for both cognitive and mental health challenges...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29673231/mapping-european-welfare-models-state-of-the-art-of-strategies-for-professional-integration-and-reintegration-of-persons-with-chronic-diseases
#12
Chiara Scaratti, Matilde Leonardi, Fabiola Silvaggi, Carolina C Ávila, Amalia Muñoz-Murillo, Panayiota Stavroussi, Olga Roka, Helena Burger, Klemens Fheodoroff, Beata Tobiasz-Adamczyk, Carla Sabariego, Eva Esteban, Sonja Gruber, Olga Svestkova, Rune Halvorsen, Asel Kadyrbaeva, Sabrina Ferraina
Background: Persons with chronic diseases (PwCDs) often experience work-related problems, and innovative actions to improve their participation in the labor market are needed. In the frame of the European (EU) Pathways Project, the aim of the study is to compare existing strategies (policies, systems, and services) for professional (re-)integration of PwCDs and mental health conditions available at both European and national level between different European welfare models: Scandinavian, Continental, Anglo-Saxon, Mediterranean, and &ldquo;Post-Communist&rdquo;...
April 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29672990/screen-time-exposure-and-sleep-among-children-with-developmental-disabilities
#13
Ramkumar Aishworiya, Jennifer Sh Kiing, Yiong Huak Chan, Serena Sw Tung, Evelyn Law
AIM: Children with developmental disabilities are at risk of excessive screen time and are more vulnerable to sleep problems. The aim of this study was to determine the extent of screen time use in children with developmental disabilities and its relationship with sleep duration. METHODS: Consecutive children aged 6-15 years diagnosed with Diagnostic and Statistical Manual of Mental Disorders, Fourth or Fifth Edition (DSM-IV or DSM-5) developmental disabilities were recruited for this study from December 2014 to April 2015...
April 19, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29672931/x-linked-ichthyosis-clinical-and-molecular-findings-in-35-italian-patients
#14
Andrea Diociaiuti, Adriano Angioni, Elisa Pisaneschi, Viola Alesi, Giovanna Zambruno, Antonio Novelli, May El Hachem
Recessive X-linked ichthyosis (XLI), the second most common ichthyosis, is caused by mutations in the STS gene encoding the steroid sulfatase enzyme. A complete deletion of the STS gene is found in 85-90% of cases. Rarely, larger deletions involving contiguous genes are detected in syndromic patients. We report the clinical and molecular genetic findings in a series of 35 consecutive Italian male patients. All patients underwent molecular testing by MLPA or aCGH, followed, in case of negative results, by next generation sequencing analysis...
April 19, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29671691/committed-action-disability-and-perceived-health-in-individuals-with-fibromyalgia
#15
Santiago Galán, Rubén Roy, Ester Solé, Mélanie Racine, Rocío de la Vega, Mark P Jensen, Jordi Miró
Committed action, one of the components of psychological flexibility, has been shown to be related with measures of pain-relevant function domains in patients with chronic pain. However, the associations between measures of committed action and of physical health and function in individuals with fibromyalgia (FM) have not yet been examined. The aim of the present cross-sectional study was to better understand the role that committed action plays in (1) pain-related disability and (2) mental and physical health in individuals with FM...
April 19, 2018: Behavioral Medicine
https://www.readbyqxmd.com/read/29670509/altered-gene-regulatory-function-of-kdm5c-by-a-novel-mutation-associated-with-autism-and-intellectual-disability
#16
Christina N Vallianatos, Clara Farrehi, Michael J Friez, Margit Burmeister, Catherine E Keegan, Shigeki Iwase
Intellectual disability (ID) affects up to 2% of the population world-wide and often coincides with other neurological conditions such as autism spectrum disorders. Mutations in KDM5C cause Mental Retardation, X-linked, Syndromic, Claes-Jensen type (MRXSCJ, OMIM #300534) and are one of the most common causes of X-linked ID. KDM5C encodes a histone demethylase for di- and tri-methylated histone H3 lysine 4 (H3K4me2/3), which are enriched in transcriptionally engaged promoter regions. KDM5C regulates gene transcription; however, it remains unknown whether removal of H3K4me is fully responsible for KDM5C-mediated gene regulation...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29668986/hits-clip-in-various-brain-areas-reveals-new-targets-and-new-modalities-of-rna-binding-by-fragile-x-mental-retardation-protein
#17
Thomas Maurin, Kevin Lebrigand, Sara Castagnola, Agnès Paquet, Marielle Jarjat, Alexandra Popa, Mauro Grossi, Florence Rage, Barbara Bardoni
Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is due to the functional deficiency of the fragile X mental retardation protein (FMRP), an RNA-binding protein involved in translational regulation of many messenger RNAs, playing key roles in synaptic morphology and plasticity. To date, no effective treatment for FXS is available. We searched for FMRP targets by HITS-CLIP during early development of multiple mouse brain regions (hippocampus, cortex and cerebellum) at a time of brain development when FMRP is most highly expressed and synaptogenesis reaches a peak...
April 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29668421/factors-associated-with-unplanned-early-discharges-from-a-dual-diagnosis-inpatient-detoxification-unit-in-israel
#18
Menachem M Sofer, Alexander Kaptsan, Jonathan Anson
OBJECTIVES: Currently, Israel has a single governmental inpatient dual diagnosis detoxification unit. We provide a cross-section of patient profiles in this unit, as well as explore possible associations between clinical/demographic factors, and the unplanned early discharge of patients from the unit, aiming at improving rehabilitation success rates. METHODS: In this retrospective study, medical records of all patients admitted to the unit between January 1st 2012 and July 1st 2013 were examined (N = 323)...
April 18, 2018: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29667699/lean-perspectives-a-case-for-implementing-parent-child-relational-problem-screening
#19
Bryson C Okeoma
The purpose of the current study was to make a case for instituting parent-child relational problem (PCRP) screening as a standard of care in pediatric inpatient psychiatric units due to increasing evidence that PCRP may be an underreported problem that affects more adolescents than currently realized. Adolescents who are admitted to the hospital for mood exacerbation, suicidal ideation, self-harm behavior, or behavioral escalation may improve and be discharged. However, these adolescents often are readmitted, which may be associated with parent-child relational factors...
April 17, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29667203/to-explore-the-efficacy-of-community-rehabilitation-for-facilitating-daily-function-among-patients-with-mental-illness
#20
Jui-Fen Cheng, Chung-Ying Chen, Mei-Chu Lin, Xuan-Yi Huang
PURPOSE: To explore the efficacy of community rehabilitation for facilitating daily function among patients with mental illness. DESIGN AND METHODS: A quasi-experimental design was used. Two hundred and sixty-four participants completed a daily living function scale questionnaire and provided disease-related information. FINDINGS: Community rehabilitation was shown to be efficient in helping to stabilize mental illness and enhance daily function...
April 17, 2018: Perspectives in Psychiatric Care
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