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Ectopic ossification

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https://www.readbyqxmd.com/read/29136292/clinical-and-genetic-characteristics-of-pseudohypoparathyroidism-in-the-chinese-population
#1
Xueying Chu, Yan Zhu, Ou Wang, Min Nie, Tingting Quan, Yu Xue, Wenbo Wang, Yan Jiang, Mei Li, Weibo Xia, Xiaoping Xing
BACKGROUND: Pseudohypoparathyroidism (PHP) is caused by mutations and epimutations in the GNAS locus, and characterized by the possibility of resistance to multiple hormones and Albright's hereditary osteodystrophy. PHP can be classified into the forms 1A/C, sporadic 1B, and familial 1B. OBJECTIVES: To obtain an overall view of the clinical and genetic characteristics of the Chinese PHP patient population. METHODS: From 2000 to 2016, 120 patients were recruited and studied using Sanger sequencing, methylation-specific multiple ligation-dependent probe amplification (MS-MLPA), and combined bisulfiterestriction analysis (COBRA)...
November 14, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29108957/matrix-vesicles-from-chondrocytes-and-osteoblasts-their-biogenesis-properties-functions-and-biomimetic-models
#2
REVIEW
Massimo Bottini, Saida Mebarek, Karen L Anderson, Agnieszka Strzelecka-Kiliszek, Lukasz Bozycki, Ana Maria Sper Simão, Maytê Bolean, Pietro Ciancaglini, Joanna Bandorowicz Pikula, Slawomir Pikula, David Magne, Niels Volkmann, Dorit Hanein, José Luis Millán, Rene Buchet
BACKGROUND: Matrix vesicles (MVs) are released from hypertrophic chondrocytes and from mature osteoblasts, the cells responsible for endochondral and membranous ossification. Under pathological conditions, they can also be released from cells of non-skeletal tissues such as vascular smooth muscle cells. MVs are extracellular vesicles of approximately 100-300nm diameter harboring the biochemical machinery needed to induce mineralization. SCOPE OF THE REVIEW: The review comprehensively delineates our current knowledge of MV biology and highlights open questions aiming to stimulate further research...
November 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29093266/macrophage-derived-oncostatin-m-contributes-to-human-and-mouse-neurogenic-heterotopic-ossifications
#3
Frédéric Torossian, Bernadette Guerton, Adrienne Anginot, Kylie A Alexander, Christophe Desterke, Sabrina Soave, Hsu-Wen Tseng, Nassim Arouche, Laetitia Boutin, Irina Kulina, Marjorie Salga, Beulah Jose, Allison R Pettit, Denis Clay, Nathalie Rochet, Erica Vlachos, Guillaume Genet, Charlotte Debaud, Philippe Denormandie, François Genet, Natalie A Sims, Sébastien Banzet, Jean-Pierre Levesque, Jean-Jacques Lataillade, Marie-Caroline Le Bousse-Kerdilès
Neurogenic heterotopic ossification (NHO) is the formation of ectopic bone generally in muscles surrounding joints following spinal cord or brain injury. We investigated the mechanisms of NHO formation in 64 patients and a mouse model of spinal cord injury-induced NHO. We show that marrow from human NHOs contains hematopoietic stem cell (HSC) niches, in which mesenchymal stromal cells (MSCs) and endothelial cells provide an environment supporting HSC maintenance, proliferation, and differentiation. The transcriptomic signature of MSCs from NHOs shows a neuronal imprinting associated with a molecular network required for HSC support...
November 2, 2017: JCI Insight
https://www.readbyqxmd.com/read/29050162/-two-stage-total-hip-arthroplasty-using-an-antibiotic-loaded-cement-spacer-for-infected-internal-fixation-of-hip-fractures
#4
X Li, M Ni, H Li, J L Song, X G Song, J Fu, K Liu, B Z Yu, J Y Chen
Objective: To evaluate the application and clinical results of two-stage total hip arthroplasty in the treatment of the deep hip infection following the internal fixation of hip fractures. Methods: From May 2007 to November 2014, 21 patients with active hip infection secondary to internal fixation of hip fractures were treated with two-stage total hip arthroplasty using a temporary antibiotic-loaded cement spacers. Of 21 cases, 15 were males and 6 were females, aged from 27 to 64 years (mean, 45); there are 18 cases of femoral neck fractures and 3 cases of intertrochanteric fractures...
October 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29039630/impairment-of-the-chondrogenic-phase-of-endochondral-ossification-in-vivo-by-inhibition-of-cyclooxygenase-2
#5
M P Janssen, M M Caron, B van Rietbergen, D A Surtel, L W van Rhijn, T J Welting, P J Emans
Many studies have reported on the effects of cyclooxygenase-2 (COX-2) inhibition on osteogenesis. However, far less is known about the effects of COX-2 inhibition on chondrogenic differentiation. Previous studies conducted by our group show that COX-2 inhibition influences in vitro chondrogenic differentiation. Importantly, this might have consequences on endochondral ossification processes occurring in vivo, such as bone fracture healing, growth plate development and ectopic generation of cartilage. The goal of our study was to investigate, in vivo, the effect of COX-2 inhibition by celecoxib on the cartilaginous phase of three different endochondral ossification scenarios...
October 17, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/29029772/inhibition-of-mammalian-target-of-rapamycin-signaling-with-rapamycin-prevents-trauma-induced-heterotopic-ossification
#6
Ammar T Qureshi, Devaveena Dey, Erin M Sanders, Jonathan G Seavey, Allison M Tomasino, Kaitlyn Moss, Benjamin Wheatley, David Cholok, Shawn Loder, John Li, Benjamin Levi, Thomas A Davis
A pressing clinical need exists for 63% to 65% of combat-wounded service members and 11% to 20% of civilians who develop heterotopic ossification (HO) after blast-related extremity injury and traumatic injuries, respectively. The mammalian target of rapamycin pathway is a central cellular sensor of injury. We evaluated the prophylactic effects of rapamycin, a selective inhibitor of mammalian target of rapamycin signaling, on HO formation in a rat model of blast-related, polytraumatic extremity injury. Rapamycin was administered intraperitoneally daily for 14 days at 0...
November 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29020504/fibrocartilage-stem-cells-engraft-and-self-organize-into-vascularized-bone
#7
J Nathan, A Ruscitto, S Pylawka, A Soharby, C J Shawber, M C Embree
Angiogenesis is a complex, multicellular process that is critical for bone development and generation. Endochondral ossification depends on an avascular cartilage template that completely remodels into vascularized bone and involves a dynamic interplay among chondrocytes, osteoblasts, and endothelial cells. We have discovered fibrocartilage stem cells (FCSCs) derived from the temporomandibular joint (TMJ) mandibular condyle that generates cartilage anlagen, which is subsequently remodeled into vascularized bone using an ectopic transplantation model...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28987285/heterotopic-ossification-and-the-elucidation-of-pathologic-differentiation
#8
David Cholok, Michael T Chung, Kavitha Ranganathan, Serra Ucer, Devaveena Day, Thomas A Davis, Yuji Mishina, Benjamin Levi
Tissue regeneration following acute or persistent inflammation can manifest a spectrum of phenotypes ranging from the adaptive to the pathologic. Heterotopic Ossification (HO), the endochondral formation of bone within soft-tissue structures following severe injury serves as a prominent example of pathologic differentiation; and remains a persistent clinical issue incurring significant patient morbidity and expense to adequately diagnose and treat. The pathogenesis of HO provides an intriguing opportunity to better characterize the cellular and cell-signaling contributors to aberrant differentiation...
October 5, 2017: Bone
https://www.readbyqxmd.com/read/28966802/the-pathogenesis-of-ossification-of-the-posterior-longitudinal-ligament
#9
REVIEW
Liang Yan, Rui Gao, Yang Liu, Baorong He, Shemin Lv, Dingjun Hao
Ossification of the posterior longitudinal ligament (OPLL) is a multi-factorial disease involving an ectopic bone formation of spinal ligaments. It affects 0.8-3.0% aging Asian and 0.1-1.7% aging European Caucasian. The ossified ligament compresses nerve roots in the spinal cord and causes serious neurological problems such as myelopathy and radiculopathy. Research in understanding pathogenesis of OPLL over the past several decades have revealed many genetic and non-genetic factors contributing to the development and progress of OPLL...
October 2017: Aging and Disease
https://www.readbyqxmd.com/read/28940647/drug-therapy-targeting-pyrophosphate-slows-the-ossification-of-spinal-ligaments-in-twy-mice
#10
Shigeto Hiratsuka, Masahiko Takahata, Tomohiro Shimizu, Hiroki Hamano, Masahiro Ota, Dai Sato, Norimasa Iwasaki
The lack of an effective drug therapy against ossification of spinal ligament (OSL) warrants investigation into the therapeutic target of this disease. An endogenous inhibitor of biomineralization, pyrophosphate (PPi) is a potential therapy for ectopic ossification; however, exogenous PPi is rapidly hydrolyzed by tissue non-specific alkaline phosphatase (TNAP) present in body fluids. In this study, we examined whether a drug therapy targeting PPi is efficacious for the treatment of OSL using the Enpp1(ttw/ttw) (twy) mouse model...
September 20, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28854256/peripheral-denervation-participates-in-heterotopic-ossification-in-a-spinal-cord-injury-model
#11
Charlotte Debaud, Marjorie Salga, Laurent Begot, Xavier Holy, Malha Chedik, Nicolas de l'Escalopier, Fréderic Torossian, Jean-Pierre Levesque, Jean-Jacques Lataillade, Marie-Caroline Le Bousse-Kerdilès, François Genêt
We previously reported the development of a new acquired neurogenic HO (NHO) mouse model, combining spinal cord transection (SCI) and chemical muscle injury. Pathological mechanisms responsible for ectopic osteogenesis after central neurological damage are still to be elucidated. In this study, we first hypothesized that peripheral nervous system (PNS) might convey pathological signals from injured spinal cord to muscles in NHO mouse model. Secondly, we sought to determine whether SCI could lead to intramuscular modifications of BMP2 signaling pathways...
2017: PloS One
https://www.readbyqxmd.com/read/28837758/natural-development-of-dermal-ectopic-bone-in-the-american-alligator-alligator-mississippiensis-resembles-heterotopic-ossification-disorders-in-humans
#12
Brooke H Dubansky, Benjamin D Dubansky
Heterotopic ossification (HO) occurs when soft tissues are inappropriately converted to bony tissue. Several human diseases result in HO with few reliable treatment options. Animal models that naturally produce dermal ectopic bone (i.e., osteoderms), such as crocodilians, have never been utilized as models for studying these disorders in humans. Here, a histological evaluation and staging criteria for osteoderm development is described for the first time in the American alligator (Alligator mississipiensis)...
August 24, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28798376/3d-biomimetic-artificial-bone-scaffolds-with-dual-cytokines-spatiotemporal-delivery-for-large-weight-bearing-bone-defect-repair
#13
Xiaogang Bao, Lingjun Zhu, Xiaodong Huang, Dezhi Tang, Dannong He, Jiangang Shi, Guohua Xu
It is a great challenge to prepare "functional artificial bone" for the repair of large segmental defect, especially in weight-bearing bones. In this study, bioactive HA/PCL composite scaffolds that possess anatomical structure as autogenous bone were fabricated by CT-guided fused deposition modeling technique. The scaffolds can provide mechanical support and possess osteoconduction property. Then the VEGF-165/BMP-2 loaded hydrogel was filled into biomimetic artificial bone spatially to introduce osteoinduction and angioinduction ability via sustained release of these cytokines...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716575/strategic-targeting-of-multiple-bmp-receptors-prevents-trauma-induced-heterotopic-ossification
#14
Shailesh Agarwal, Shawn J Loder, Christopher Breuler, John Li, David Cholok, Cameron Brownley, Jonathan Peterson, Hsiao H Hsieh, James Drake, Kavitha Ranganathan, Yashar S Niknafs, Wenzhong Xiao, Shuli Li, Ravindra Kumar, Ronald Tompkins, Michael T Longaker, Thomas A Davis, Paul B Yu, Yuji Mishina, Benjamin Levi
Trauma-induced heterotopic ossification (tHO) is a condition of pathologic wound healing, defined by the progressive formation of ectopic bone in soft tissue following severe burns or trauma. Because previous studies have shown that genetic variants of HO, such as fibrodysplasia ossificans progressiva (FOP), are caused by hyperactivating mutations of the type I bone morphogenetic protein receptor (T1-BMPR) ACVR1/ALK2, studies evaluating therapies for HO have been directed primarily toward drugs for this specific receptor...
August 2, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28668522/the-traumatic-bone-trauma-induced-heterotopic-ossification
#15
REVIEW
Devaveena Dey, Benjamin M Wheatley, David Cholok, Shailesh Agarwal, Paul B Yu, Benjamin Levi, Thomas A Davis
Heterotopic ossification (HO) is a common occurrence after multiple forms of extensive trauma. These include arthroplasties, traumatic brain and spinal cord injuries, extensive burns in the civilian setting, and combat-related extremity injuries in the battlefield. Irrespective of the form of trauma, heterotopic bone is typically endochondral in structure and is laid down via a cartilaginous matrix. Once formed, the heterotopic bone typically needs to be excised surgically, which may result in wound healing complications, in addition to a risk of recurrence...
August 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28648877/a-rare-presentation-a-case-report-of-osseous-metaplasia-and-mature-bone-formation-in-a-follicular-adenoma-of-the-thyroid
#16
Nadia Aurora, Insia Hashmi, Subhasis Misra, Nail Aydin
INTRODUCTION: Cases of multinodular goiter, thyroid hyperplasia, follicular adenoma, papillary thyroid carcinoma, and anaplastic thyroid carcinoma have been reported with histopathologic findings of osseous metaplasia (OM), bone marrow metaplasia (BMM), ectopic bone formation (EBF), ossification, and extramedullary hematopoiesis (EMH). To date no report of a follicular adenoma with OM and mature EBF in the absence of EMH has been reported in the English language. PRESENTATION OF CASE: 63-year-old woman with an incidental finding of thyroid nodule unable to be biopsied...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28621436/development-of-a-cell-based-gene-therapy-approach-to-selectively-turn-off-bone-formation
#17
Pedro Alvarez-Urena, Banghe Zhu, Gabrielle Henslee, Corinne Sonnet, Eleanor Davis, Eva Sevick-Muraca, Alan Davis, Elizabeth Olmsted-Davis
Cell and gene therapy approaches are safer when they possess a system that enables the therapy to be rapidly halted. Human mesenchymal stem cells were transduced with an adenoviral vector containing the cDNA for bone morphogenetic protein 2 (AdBMP2) to induce bone formation. To make this method safer, a system to quickly kill these virally transduced cells was designed and evaluated. Cells were encapsulated inside poly(ethylene glycol) diacrylate (PEG-Da) hydrogels that are able to shield the cells from immunological destruction...
June 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28616259/hyperphosphatemia-in-a-patient-with-spinal-cord-injury-who-received-etidronate-for-the-treatment-of-heterotopic-ossification
#18
Sahil Taravati, Ece Cinar, Yesim Akkoc
INTRODUCTION: Heterotopic ossification (HO) is defined as ectopic bone formation around peripheral joints and in soft tissues. HO is a common complication of diseases of the central nervous system, such as spinal cord injury (SCI) and traumatic brain injury. HO is seen in up to 50% of patients with SCI and typically occurs in the first 12 weeks after onset of injury. Although no treatment method is proven to be curative, nonsteroidal anti-inflammatory drugs, irradiation of the involved body part and bisphosphonates are commonly used in the management of HO...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28600846/ectopic-implantation-of-juvenile-osteochondral-tissues-recapitulates-endochondral-ossification
#19
Johnathan Ng, Yiyong Wei, Bin Zhou, Sarindr Bhumiratana, Aonnicha Burapachaisri, Edward Guo, Gordana Vunjak-Novakovic
Subcutaneous implantation in a mouse can be used to investigate tissue maturation in vivo. Here, we demonstrate that this simple model can recapitulate endochondral ossification associated with native skeletal development. By histological and μCT analysis, we investigated morphological changes of immature bovine osteochondral tissues over the course of subcutaneous implantation in immunocompromised mice for up to 10 weeks. We observed multiple similarities between the ectopic process and native endochondral ossification: (i) permanent cartilage retention in the upper zones, (ii) progressive loss of transient cartilage accompanied by bone formation at the interface, and (iii) remodeling of nascent endochondral bone into mature cancellous bone...
June 10, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28575129/the-involvement-and-possible-mechanism-of-pro-inflammatory-tumor-necrosis-factor-alpha-tnf-%C3%AE-in-thoracic-ossification-of-the-ligamentum-flavum
#20
Chi Zhang, Zhongqiang Chen, Xiangyu Meng, Mengtao Li, Li Zhang, Ann Huang
Thoracic ossification of the ligamentum flavum (TOLF) is characterized by ectopic bone formation in the ligamentum flavum and is considered to be a leading cause of thoracic spinal canal stenosis and myelopathy. However, the underlying etiology is not well understood. An iTRAQ proteomics was used to reveal the involvement of inflammation factors in TOLF. TNF-α is a pro-inflammatory cytokine implicated in the pathogenesis of many human diseases. Protein profiling analysis showed that the protein level of TNF-α increased in the ossified ligamentum flavum of TOLF, which was confirmed by western blot...
2017: PloS One
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