keyword
MENU ▼
Read by QxMD icon Read
search

UTY

keyword
https://www.readbyqxmd.com/read/28853720/the-y-chromosome-a-blueprint-for-men-s-health
#1
REVIEW
Akhlaq A Maan, James Eales, Artur Akbarov, Joshua Rowland, Xiaoguang Xu, Mark A Jobling, Fadi J Charchar, Maciej Tomaszewski
The Y chromosome has long been considered a 'genetic wasteland' on a trajectory to completely disappear from the human genome. The perception of its physiological function was restricted to sex determination and spermatogenesis. These views have been challenged in recent times with the identification of multiple ubiquitously expressed Y-chromosome genes and the discovery of several unexpected associations between the Y chromosome, immune system and complex polygenic traits. The collected evidence suggests that the Y chromosome influences immune and inflammatory responses in men, translating into genetically programmed susceptibility to diseases with a strong immune component...
November 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28853286/y-chromosome-missing-protein-tbl1y-may-play-an-important-role-in-cardiac-differentiation
#2
Anna Meyfour, Hassan Ansari, Sara Pahlavan, Shahab Mirshahvaladi, Mostafa Rezaei-Tavirani, Hamid Gourabi, Hossein Baharvand, Ghasem Hosseini Salekdeh
Despite evidence for sex-specific cardiovascular physiology and pathophysiology, the biological basis for this dimorphism remains to be explored. Apart from hormonal factors, gender related characteristics may reside in the function of sex chromosomes during cardiac development. In this study, we investigated the differential expression of the male-specific region of the Y chromosome (MSY) genes and their X counterparts during cardiac differentiation of human embryonic stem cells (hESC). We observed alterations in mRNA and protein levels of TBL1Y, PCDH11Y, ZFY, KDM5D, USP9Y, RPS4Y1, DDX3Y, PRY, XKRY, BCORP1, RBMY, HSFY, and UTY which accompanied changes in intracellular localization...
August 30, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28529687/histone-demethylases-utx-and-jmjd3-are-required-for-nkt-cell-development-in-mice
#3
Daniel Northrup, Ryoji Yagi, Kairong Cui, William R Proctor, Chaochen Wang, Katarzyna Placek, Lance R Pohl, Rongfu Wang, Kai Ge, Jinfang Zhu, Keji Zhao
BACKGROUND: Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties. The role of histone modifying enzymes in conventional T cell development has been extensively studied, little is known about the function of enzymes regulating histone methylation in NKT cells. RESULTS: We show that conditional deletion of histone demethylases UTX and JMJD3 by CD4-Cre leads to near complete loss of liver NKT cells, while conventional T cells are less affected...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28150810/differential-lactate-and-cholesterol-synthetic-activities-in-xy-and-xx-sertoli-cells
#4
Yurina Shishido, Takashi Baba, Tetsuya Sato, Yuichi Shima, Kanako Miyabayashi, Miki Inoue, Haruhiko Akiyama, Hiroshi Kimura, Yoshiakira Kanai, Yasuhiro Ishihara, Shogo Haraguchi, Akira Miyazaki, Damjana Rozman, Takeshi Yamazaki, Man-Ho Choi, Yasuyuki Ohkawa, Mikita Suyama, Ken-Ichirou Morohashi
SRY, a sex-determining gene, induces testis development in chromosomally female (XX) individuals. However, mouse XX Sertoli cells carrying Sry (XX/Sry Sertoli cells) are incapable of fully supporting germ cell development, even when the karyotype of the germ cells is XY. While it has therefore been assumed that XX/Sry Sertoli cells are not functionally equivalent to XY Sertoli cells, it has remained unclear which specific functions are affected. To elucidate the functional difference, we compared the gene expression of XY and XX/Sry Sertoli cells...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28132772/profiling-of-human-epigenetic-regulators-using-a-semi-automated-real-time-qpcr-platform-validated-by-next-generation-sequencing
#5
Amel Dudakovic, Martina Gluscevic, Christopher R Paradise, Halil Dudakovic, Farzaneh Khani, Roman Thaler, Farah S Ahmed, Xiaodong Li, Allan B Dietz, Gary S Stein, Martin A Montecino, David R Deyle, Jennifer J Westendorf, Andre J van Wijnen
Epigenetic mechanisms control phenotypic commitment of mesenchymal stromal/stem cells (MSCs) into osteogenic, chondrogenic or adipogenic lineages. To investigate enzymes and chromatin binding proteins controlling the epigenome, we developed a hybrid expression screening strategy that combines semi-automated real-time qPCR (RT-qPCR), next generation RNA sequencing (RNA-seq), and a novel data management application (FileMerge). This strategy was used to interrogate expression of a large cohort (n>300) of human epigenetic regulators (EpiRegs) that generate, interpret and/or edit the histone code...
April 20, 2017: Gene
https://www.readbyqxmd.com/read/27558303/novel-y-chromosome-short-tandem-repeats-in-sus-scrofa-and-their-variation-in-european-wild-boar-and-domestic-pig-populations
#6
L Iacolina, V Brajković, A Canu, N Šprem, V Cubric-Curik, L Fontanesi, U Saarma, M Apollonio, M Scandura
Y-chromosome markers are important tools for studying male-specific gene flow within and between populations, hybridization patterns and kinship. However, their use in non-human mammals is often hampered by the lack of Y-specific polymorphic markers. We identified new male-specific short tandem repeats (STRs) in Sus scrofa using the available genome sequence. We selected four polymorphic loci (5-10 alleles per locus), falling in one duplicated and two single-copy regions. A total of 32 haplotypes were found by screening 211 individuals from eight wild boar populations across Europe and five domestic pig populations...
December 2016: Animal Genetics
https://www.readbyqxmd.com/read/27533081/target-sequencing-and-crispr-cas-editing-reveal-simultaneous-loss-of-utx-and-uty-in-urothelial-bladder-cancer
#7
Jinwoo Ahn, Kwang Hyun Kim, Sanghui Park, Young-Ho Ahn, Ha Young Kim, Hana Yoon, Ji Hyun Lee, Duhee Bang, Dong Hyeon Lee
UTX is a histone demethylase gene located on the X chromosome and is a frequently mutated gene in urothelial bladder cancer (UBC). UTY is a paralog of UTX located on the Y chromosome. We performed target capture sequencing on 128 genes in 40 non-metastatic UBC patients. UTX was the most frequently mutated gene (30%, 12/40). Of the genetic alterations identified, 75% were truncating mutations. UTY copy number loss was detected in 8 male patients (22.8%, 8/35). Of the 9 male patients with UTX mutations, 6 also had copy number loss (66...
September 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27339988/identification-of-an-nkx3-1-g9a-uty-transcriptional-regulatory-network-that-controls-prostate-differentiation
#8
Aditya Dutta, Clémentine Le Magnen, Antonina Mitrofanova, Xuesong Ouyang, Andrea Califano, Cory Abate-Shen
The NKX3.1 homeobox gene plays essential roles in prostate differentiation and prostate cancer. We show that loss of function of Nkx3.1 in mouse prostate results in down-regulation of genes that are essential for prostate differentiation, as well as up-regulation of genes that are not normally expressed in prostate. Conversely, gain of function of Nkx3.1 in an otherwise fully differentiated nonprostatic mouse epithelium (seminal vesicle) is sufficient for respecification to prostate in renal grafts in vivo...
June 24, 2016: Science
https://www.readbyqxmd.com/read/27333765/ancestral-y-linked-genes-were-maintained-by-translocation-to-the-x-and-y-chromosomes-fused-to-an-autosomal-pair-in-the-okinawa-spiny-rat-tokudaia-muenninki
#9
Chie Murata, Yoko Kuroki, Issei Imoto, Asato Kuroiwa
Two species of the genus Tokudaia lack the Y chromosome and SRY, but several Y-linked genes have been rescued by translocation or transposition to other chromosomes. Tokudaia muenninki is the only species in the genus that maintains the Y owing to sex chromosome-autosome fusions. According to previous studies, many SRY pseudocopies and other Y-linked genes have evolved by excess duplication in this species. Using RNA-seq and RT-PCR, we found that ZFY, EIF2S3Y, TSPY, UTY, DDX3Y, USP9Y, and RBMY, but not UBA1Y, had high deduced amino acid sequence similarity and similar expression patterns with other rodents, suggesting that these genes were functional...
September 2016: Chromosome Research
https://www.readbyqxmd.com/read/27302555/mutation-update-for-kabuki-syndrome-genes-kmt2d-and-kdm6a-and-further-delineation-of-x-linked-kabuki-syndrome-subtype-2
#10
Nina Bögershausen, Vincent Gatinois, Vera Riehmer, Hülya Kayserili, Jutta Becker, Michaela Thoenes, Pelin Özlem Simsek-Kiper, Mouna Barat-Houari, Nursel H Elcioglu, Dagmar Wieczorek, Sigrid Tinschert, Guillaume Sarrabay, Tim M Strom, Aurélie Fabre, Gareth Baynam, Elodie Sanchez, Gudrun Nürnberg, Umut Altunoglu, Yline Capri, Bertrand Isidor, Didier Lacombe, Carole Corsini, Valérie Cormier-Daire, Damien Sanlaville, Fabienne Giuliano, Kim-Hanh Le Quan Sang, Honorine Kayirangwa, Peter Nürnberg, Thomas Meitinger, Koray Boduroglu, Barbara Zoll, Stanislas Lyonnet, Andreas Tzschach, Alain Verloes, Nataliya Di Donato, Isabelle Touitou, Christian Netzer, Yun Li, David Geneviève, Gökhan Yigit, Bernd Wollnik
Kabuki syndrome (KS) is a rare but recognizable condition that consists of a characteristic face, short stature, various organ malformations, and a variable degree of intellectual disability. Mutations in KMT2D have been identified as the main cause for KS, whereas mutations in KDM6A are a much less frequent cause. Here, we report a mutation screening in a case series of 347 unpublished patients, in which we identified 12 novel KDM6A mutations (KS type 2) and 208 mutations in KMT2D (KS type 1), 132 of them novel...
September 2016: Human Mutation
https://www.readbyqxmd.com/read/27284354/identification-of-nondiabetic-heart-failure-associated-genes-by-bioinformatics-approaches-in-patients-with-dilated-ischemic-cardiomyopathy
#11
Anzhong Yu, Jingyao Zhang, Haiyan Liu, Bing Liu, Lingdong Meng
Heart failure (HF) is a common pathological condition affecting 4% of the worldwide population. However, approaches for predicting or treating nondiabetic HF (ND-HF) progression are insufficient. In the current study, the gene expression profile GSE26887 was analyzed, which contained samples from 5 healthy controls, 7 diabetes mellitus-HF patients and 12 ND-HF patients with dilated ischemic cardiomyopathy. The dataset of 5 healthy controls and 12 ND-HF patients was normalized with robust multichip average analysis and the differentially expressed genes (DEGs) were screened by unequal variance t-test and multiple-testing correction...
June 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26999603/utx-demethylase-activity-is-required-for-satellite-cell-mediated-muscle-regeneration
#12
Hervé Faralli, Chaochen Wang, Kiran Nakka, Aissa Benyoucef, Soji Sebastian, Lenan Zhuang, Alphonse Chu, Carmen G Palii, Chengyu Liu, Brendan Camellato, Marjorie Brand, Kai Ge, F Jeffrey Dilworth
The X chromosome-encoded histone demethylase UTX (also known as KDM6A) mediates removal of repressive trimethylation of histone H3 lysine 27 (H3K27me3) to establish transcriptionally permissive chromatin. Loss of UTX in female mice is embryonic lethal. Unexpectedly, male UTX-null mice escape embryonic lethality due to expression of UTY, a paralog that lacks H3K27 demethylase activity, suggesting an enzyme-independent role for UTX in development and thereby challenging the need for active H3K27 demethylation in vivo...
April 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26690523/mutational-landscape-of-the-human-y-chromosome-linked-genes-and-loci-in-patients-with-hypogonadism
#13
Deepali Pathak, Sandeep Kumar Yadav, Leena Rawal, Sher Ali
Sex chromosome-related anomalies engender plethora of conditions leading to male infertility. Hypogonadotropic hypogonadism (HH) is a rare but well-known cause of male infertility. Present study was conducted to ascertain possible consensus on the alterations of the Y-linked genes and loci in males representing hypogonadism (H), which in turn culminate in reproductive dysfunction. A total of nineteen 46, XY males, clinically diagnosed with H (11 representative HH adults and eight prepubertal boys suspected of having HH) were included in the study...
December 2015: Journal of Genetics
https://www.readbyqxmd.com/read/26513216/tolerance-induction-using-nanoparticles-bearing-hy-peptides-in-bone-marrow-transplantation
#14
Kelan A Hlavaty, Derrick P McCarthy, Eiji Saito, Woon Teck Yap, Stephen D Miller, Lonnie D Shea
Allogeneic cell therapies have either proven effective or have great potential in numerous applications, though the required systemic, life-long immunosuppression presents significant health risks. Inducing tolerance to allogeneic cells offers the potential to reduce or eliminate chronic immunosuppression. Herein, we investigated antigen-loaded nanoparticles for their ability to promote transplant tolerance in the minor histocompatibility antigen sex-mismatched C57BL/6 model of bone marrow transplantation. In this model, the peptide antigens Dby and Uty mediate rejection of male bone marrow transplants by female CD4+ and CD8+ T cells, respectively, and we investigated the action of nanoparticles on these T cell subsets...
January 2016: Biomaterials
https://www.readbyqxmd.com/read/26328764/histone-h3-lysine-27-demethylases-jmjd3-and-utx-are-required-for-t-cell-differentiation
#15
Sugata Manna, Jong Kyong Kim, Catherine Baugé, Margaret Cam, Yongmei Zhao, Jyoti Shetty, Melanie S Vacchio, Ehydel Castro, Bao Tran, Lino Tessarollo, Rémy Bosselut
Although histone H3 lysine 27 trimethylation (H3K27Me3) is associated with gene silencing, whether H3K27Me3 demethylation affects transcription and cell differentiation in vivo has remained elusive. To investigate this, we conditionally inactivated the two H3K27Me3 demethylases, Jmjd3 and Utx, in non-dividing intrathymic CD4(+) T-cell precursors. Here we show that both enzymes redundantly promote H3K27Me3 removal at, and expression of, a specific subset of genes involved in terminal thymocyte differentiation, especially S1pr1, encoding a sphingosine-phosphate receptor required for thymocyte egress...
2015: Nature Communications
https://www.readbyqxmd.com/read/26144214/ddx3y-a-male-specific-region-of-y-chromosome-gene-may-modulate-neuronal-differentiation
#16
Haghighat Vakilian, Mehdi Mirzaei, Mehdi Sharifi Tabar, Paria Pooyan, Lida Habibi Rezaee, Lindsay Parker, Paul A Haynes, Hamid Gourabi, Hossein Baharvand, Ghasem Hosseini Salekdeh
Although it is apparent that chromosome complement mediates sexually dimorphic expression patterns of some proteins that lead to functional differences, there has been insufficient evidence following the manipulation of the male-specific region of the Y chromosome (MSY) gene expression during neural development. In this study, we profiled the expression of 23 MSY genes and 15 of their X-linked homologues during neural cell differentiation of NTERA-2 human embryonal carcinoma cell line (NT2) cells in three different developmental stages using qRT-PCR, Western blotting, and immunofluorescence...
September 4, 2015: Journal of Proteome Research
https://www.readbyqxmd.com/read/26011180/east-african-pigs-have-a-complex-indian-far-eastern-and-western-ancestry
#17
A Noce, M Amills, A Manunza, V Muwanika, D Muhangi, T Aliro, J Mayega, R Ademun, A Sànchez, S Egbhalsaied, A Mercadé, C Masembe
In this study, we have characterized the mitochondrial diversity of 81 swine from Uganda. Median-joining network analysis of D-loop sequences from these individuals and others characterized in previous studies allowed us to determine that Ugandan pigs cluster with populations from the West (Europe/North Africa), Far East and India. In addition, partial sequencing of the Y-chromosome UTY locus in 18 Ugandan domestic pigs revealed the segregation of a single HY1 lineage that has a cosmopolitan distribution. A Western and Far Eastern ancestry for East African pigs had been already reported, but this is the first study demonstrating an additional contribution from the Indian porcine gene pool...
August 2015: Animal Genetics
https://www.readbyqxmd.com/read/25992976/temporal-fluctuation-in-north-east-baltic-sea-region-cattle-population-revealed-by-mitochondrial-and-y-chromosomal-dna-analyses
#18
Marianna Niemi, Auli Bläuer, Terhi Iso-Touru, Janne Harjula, Veronica Nyström Edmark, Eve Rannamäe, Lembi Lõugas, Antti Sajantila, Kerstin Lidén, Jussi-Pekka Taavitsainen
BACKGROUND: Ancient DNA analysis offers a way to detect changes in populations over time. To date, most studies of ancient cattle have focused on their domestication in prehistory, while only a limited number of studies have analysed later periods. Conversely, the genetic structure of modern cattle populations is well known given the undertaking of several molecular and population genetic studies. RESULTS: Bones and teeth from ancient cattle populations from the North-East Baltic Sea region dated to the Prehistoric (Late Bronze and Iron Age, 5 samples), Medieval (14), and Post-Medieval (26) periods were investigated by sequencing 667 base pairs (bp) from the mitochondrial DNA (mtDNA) and 155 bp of intron 19 in the Y-chromosomal UTY gene...
2015: PloS One
https://www.readbyqxmd.com/read/25957587/copy-number-variation-in-the-human-y-chromosome-in-the-uk-population
#19
Wei Wei, Tomas W Fitzgerald, Tomas Fitzgerald, Qasim Ayub, Andrea Massaia, Blair H Smith, Blair B Smith, Anna F Dominiczak, Anna A Dominiczak, Andrew D Morris, Andrew A Morris, David J Porteous, David D Porteous, Matthew E Hurles, Chris Tyler-Smith, Yali Xue
We have assessed copy number variation (CNV) in the male-specific part of the human Y chromosome discovered by array comparative genomic hybridization (array-CGH) in 411 apparently healthy UK males, and validated the findings using SNP genotype intensity data available for 149 of them. After manual curation taking account of the complex duplicated structure of Y-chromosomal sequences, we discovered 22 curated CNV events considered validated or likely, mean 0.93 (range 0-4) per individual. 16 of these were novel...
July 2015: Human Genetics
https://www.readbyqxmd.com/read/25766725/allogeneic-hy-antibodies-detected-3-months-after-female-to-male-hct-predict-chronic-gvhd-and-nonrelapse-mortality-in-humans
#20
Hideki Nakasone, Lu Tian, Bita Sahaf, Takakazu Kawase, Kelsi Schoenrock, Spenser Perloff, Christine E Ryan, Jed Paul, Rakesh Popli, Fang Wu, Joanne M Otani, John Coller, Edus H Warren, David B Miklos
Allogeneic antibodies against minor histocompatibility antigens encoded on the Y chromosome (HY-Abs) develop after hematopoietic cell transplant (HCT) of male recipients with female donors (F→M). However, the temporal association between HY-Ab development and chronic graft-versus-host disease (cGVHD) has yet to be elucidated. We studied 136 adult F→M HCT patients, with plasma prospectively collected through 3 years posttransplant, and measured immunoglobulin G against 6 H-Y antigens. Multiple HY-Abs were frequently detected beginning at 3 months posttransplant: 78 (57%) of F→M patients were seropositive for at least 1 of the 6 HY-Abs, and 3-month seropositivity for each HY-Ab was associated with a persistent seropositive response throughout the posttransplant follow-up period (P < ...
May 14, 2015: Blood
keyword
keyword
21214
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"