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Chronic spontaneous urticaria

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https://www.readbyqxmd.com/read/29786879/comorbidity-of-viral-hepatitis-and-chronic-spontaneous-urticaria-a-systematic-review
#1
REVIEW
Pavel Kolkhir, Natalia Pereverzina, Olga Olisova, Marcus Maurer
Chronic viral infections including those by hepatitis B (CHB) virus and hepatitis C (CHC) virus have been reported to be comorbidities of chronic spontaneous urticaria (CSU). Here, we performed the first comprehensive review of the peer-reviewed literature (Pubmed, Web of Science and Google Scholar) on the prevalence of CHB and CHC in patients with CSU and vice versa. The prevalence of CHB and CHC in CSU does not appear to be increased. Less than 5% and less than 2% of CSU patients have markers of CHB and CHC, respectively, according to most of the 32 studies reviewed...
May 22, 2018: Allergy
https://www.readbyqxmd.com/read/29785187/the-association-between-sexual-dysfunctions-and-severity-of-symptoms-in-patients-with-chronic-spontaneous-urticaria
#2
Agnieszka Skrzypulec-Frankel, Katarzyna Bieniek, Alicja Kasperska-Zając
No abstract text is available yet for this article.
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29772036/chronic-urticaria-following-practice-guidelines
#3
E P Westby, C Lynde, G Sussman
Histamine is a key inflammatory player in the pathogenesis of urticaria, a mast-cell-driven disease characterized clinically by the development of wheals, angioedema, or both. Changes to the management of chronic spontaneous urticaria have recently been adopted due to increasing literature surrounding the efficacy and safety of up-dosing modern second-generation H1 -antihistamines and the use of omalizamub, a biologic agent, as a third-line treatment. Given the prevalence of chronic urticaria and its impact on quality of life, this editorial aims to provide a summary of the proposed updated guidelines for the management of chronic urticaria as agreed upon at the 5th Consensus Conference on the Update and Revision of the EAACI/GA2 LEN/EDF/WAO Guideline for Urticaria in Berlin in December 2016...
May 2018: Skin Therapy Letter
https://www.readbyqxmd.com/read/29770909/omalizumab-in-chronic-spontaneous-urticaria-refractory-to-conventional-therapy-an-italian-retrospective-clinical-analysis-with-suggestions-for-long-term-maintenance-strategies
#4
Victor D Mandel, Mario B Guanti, Serena Liberati, Antongiulio Demonte, Giovanni Pellacani, Patrizia Pepe
INTRODUCTION: Omalizumab is indicated for the treatment of patients affected by chronic spontaneous urticaria (CSU) refractory to antihistamines. The aim of this study was to assess the efficacy, safety, and recurrence of symptoms in a real-life experience of omalizumab as an add-on therapy for H1 -antihistamine-refractory CSU patients (refractory CSU). METHODS: A retrospective review of the clinical records of all refractory CSU treated with omalizumab at our dermatology center from June 2014 to April 2017 was performed...
May 16, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29769469/-activation-mechanisms-of-mast-cells-in-chronic-spontaneous-urticaria
#5
Yoshimichi Okayama
No abstract text is available yet for this article.
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29750467/chronic-urticaria-what-does-the-new-guideline-tell-us
#6
Marcus Maurer, Torsten Zuberbier, Frank Siebenhaar, Karoline Krause
Patients with chronic urticaria experience significant impairment, and require an effective treatment. Such treatment is preceded by a thorough diagnostic workup and measurement of disease activity, disease burden and disease control using well--established tools. Treatment is subsequently adjusted according to patient needs and therapeutic response, based on the tenet "as much as necessary, as little as possible" (in that order). Once disease control has been achieved, it is recommended that intermittent attempts at medication withdrawal be made in order to identify spontaneous disease remission...
May 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29734181/which-fruits-and-vegetables-should-be-excluded-from-a-low-salicylate-diet-an-analysis-of-salicylic-acid-in-foodstuffs-in-taiwan
#7
Hui-Ling Chiang, Carina Venter, Pai-Chi Syue, Kuo-Lung Ku, Cheng-Han Wu
BACKGROUND: Eliminating pseudoallergens is an important element of managing chronic spontaneous urticaria (CSU). Salicylic acid (SA) is a primary pseudoallergen in plant-based foodstuffs. Current dietary recommendations are not applicable in East Asia because data on the SA content of many vegetables and fruits commonly consumed in this region are lacking. METHODS: We therefore determined the concentration of free SA in 79 popular vegetables and fruits frequently consumed in Taiwan using gas chromatography-mass spectrometry...
May 7, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29733981/montelukast-reduces-symptom-severity-and-frequency-in-patients-with-angioedema-predominant-chronic-spontaneous-urticaria
#8
Ayobami T Akenroye, Conor McEwan, Sarbjit S Saini
No abstract text is available yet for this article.
May 4, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29729103/effectiveness-of-omalizumab-in-chronic-spontaneous-urticaria-assessed-with-patient-reported-outcomes-a-prospective-study
#9
Misbah Noshela Ghazanfar, Jesper Grønlund Holm, Simon Francis Thomsen
AIM: To examine the effectiveness of omalizumab (anti-IgE) on symptoms and disease-related quality of life in chronic spontaneous urticaria (CSU), and to identify possible patient specific factors associated with response to omalizumab in patients with antihistamine refractory CSU. METHODS: Six months prospective trial of omalizumab 300 mg every four weeks among patients with CSU from a dermatological university department. The primary outcome was the urticaria activity score in the past week (UAS7) at three months...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29698966/diamine-oxidase-supplementation-in-chronic-spontaneous-urticaria-a-randomized-double-blind-placebo-controlled-study
#10
Mona-Rita Yacoub, Giuseppe A Ramirez, Alvise Berti, Giuseppe Mercurio, Daniela Breda, Nicoletta Saporiti, Samuele Burastero, Lorenzo Dagna, Giselda Colombo
INTRODUCTION: Diamine oxidase (DAO) catabolizes and inactivates histamine, a key player in a wide range of invalidating conditions, such as migraine and chronic spontaneous urticaria (CSU). The highest expression of DAO occurs in the gastrointestinal tract, possibly to control the burden of histamine intake from food. METHODS: Here, we tested the hypothesis that a 30-day oral supplementation with DAO (1 capsule b.i.d., 15 min before a meal) could reduce the severity of CSU as estimated by the 7-Day Urticaria Activity Score (UAS-7)...
April 26, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29686678/immunoglobulin-e-mediated-autoimmunity
#11
REVIEW
Marcus Maurer, Sabine Altrichter, Oliver Schmetzer, Jörg Scheffel, Martin K Church, Martin Metz
The study of autoimmunity mediated by immunoglobulin E (IgE) autoantibodies, which may be termed autoallergy, is in its infancy. It is now recognized that systemic lupus erythematosus, bullous pemphigoid (BP), and chronic urticaria, both spontaneous and inducible, are most likely to be mediated, at least in part, by IgE autoantibodies. The situation in other conditions, such as autoimmune uveitis, rheumatoid arthritis, hyperthyroid Graves' disease, autoimmune pancreatitis, and even asthma, is far less clear but evidence for autoallergy is accumulating...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29679413/prevalence-and-clinical-characteristics-of-chronic-spontaneous-urticaria-in-pediatric-patients
#12
Maria-Magdalena Balp, Karsten Weller, Veruska Carboni, Alexandra Chirilov, Charis Papavassilis, Thomas Severin, Haijun Tian, Torsten Zuberbier, Marcus Maurer
BACKGROUND: Data on the prevalence and disease management of chronic urticaria (CU) and chronic spontaneous urticaria (CSU) in the pediatric population are scarce. The present study assessed the prevalence of CU and CSU, and disease management among pediatric patients (0-17 years). METHODS: A physician-based online survey was conducted in 5 European countries (United Kingdom, Germany, Italy, France, and Spain) assessing the annual diagnosed prevalence, disease characteristics and treatment patterns in the target population...
April 21, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29669665/diagnosis-pathogenesis-and-treatment-of-chronic-spontaneous-urticaria
#13
Allen P Kaplan
BACKGROUND: Chronic Spontaneous Urticaria (CSU) is an endogenous disorder that is strongly associated with autoimmunity, particularly with immunoglobulin G (IgG) antibody to the alpha subunit of the IgE receptor seen in 35-40% of patients. Basophils and cutaneous mast cells can be activated and lead to a late-phase-like perivascular infiltration about small venules and hive formation. METHODS: Review of current literature. RESULTS: Antibody to thyroid antigens are seen in 25% of patients; a small fraction of these may be clinically hypothyroid (Hashimoto's Thyroiditis)...
May 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29655772/predicting-chronic-spontaneous-urticaria-symptom-return-after-omalizumab-treatment-discontinuation-exploratory-analysis
#14
Marta Ferrer, Ana Giménez-Arnau, Diego Saldana, Nico Janssens, Maria-Magdalena Balp, Sam Khalil, Valéry Risson
BACKGROUND: Omalizumab is highly effective in controlling chronic spontaneous urticaria (CSU) symptoms; however, patients can experience symptom return upon treatment discontinuation. Pivotal clinical trials have identified two categories of patients who experience symptom return: rapid and slow. OBJECTIVE: To identify potential predictors of the speed of symptom return after stopping omalizumab treatment. METHODS: Phase III randomized controlled trial (RCT) data from ASTERIA I (n=319; 6x4-weekly injections of omalizumab 75, 150, 300 mg or placebo; NCT01287117) and ASTERIA II (n=323; 3x4-weekly injections of omalizumab 75, 150, 300 mg or placebo; NCT01292473) were pooled to identify predictors of symptom return after stopping omalizumab treatment (16-week follow-up)...
April 12, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29650762/high-dose-antihistamines-for-chronic-spontaneous-urticaria-in-adults
#15
(no author information available yet)
Chronic spontaneous urticaria (CSU) is a common skin disease characterised by intermittent weals (hives), angioedema or both lasting for at least 6 weeks.1-3 Second-generation antihistamines are widely used to manage symptoms but are not completely effective in many patients at licensed doses.4 Some guidelines recommend off-label use of high-dose antihistamines as the next therapeutic step.2,3 Here, we review the evidence supporting this recommendation.
April 2018: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/29649806/rituximab-in-refractory-chronic-spontaneous-urticaria-an-encouraging-therapeutic-approach
#16
Andrea Combalia, Ricardo A Losno, Sergio Prieto-González, J Manuel Mascaró
BACKGROUND: Chronic spontaneous urticaria (CSU) is a frequent mast cell-driven disease that affects approximately 0.5-1% of the population. Antihistamines are currently the drugs of choice in patients with CSU. Omalizumab has been shown to be very effective in CSU and has been recently approved as second-line therapy. However, although its introduction has markedly improved the therapeutic possibilities for CSU, there is still a hard core of patients who do not respond and require effective treatment...
April 12, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29648675/clinical-features-of-chronic-spontaneous-urticaria-that-predict-disease-prognosis-and-refractoriness-to-standard-treatment
#17
Laia Curto-Barredo, Laura Riba Archilla, Guillem Roura Vives, Ramon M Pujol, Ana M Giménez-Arnau
Chronic spontaneous urticaria (CSU) is characterized by heterogeneous activity, evolution, associated comorbidities and response to treatment. The aim of this study was to identify prognostic factors in patients with CSU that predict disease course and response to standard treatments. An observational retrospective study was conducted in a cohort of 549 patients with CSU, comparing patients with isolated CSU and those with CSU with concomitant inducible urticaria (CSU-CIndU). The factors associated with a worse prognosis in terms of duration and/or CSU activity and its episodes were: multiple episodes of CSU (19...
April 12, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29606813/a-histamine-free-diet-is-helpful-for-treatment-of-adult-patients-with-chronic-spontaneous-urticaria
#18
Jee Hee Son, Bo Young Chung, Hye One Kim, Chun Wook Park
Background: In adult patients with chronic urticaria (CU), the prevalence of food allergy is low compared to childhood patients. However, there are many patients who report food-related aggravation of CU, and some of them may have histamine intolerance. Objective: The aim of this study was to evaluate the role of ingested histamine and to investigate the effect of a histamine-free diet in adult patients with CU. Methods: Twenty-two adult patients with CU were enrolled...
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29574551/the-dysfunction-of-the-cerebellum-and-its-cerebellum-reward-sensorimotor-loops-in-chronic-spontaneous-urticaria
#19
Yuming Wang, Jiliang Fang, Ping Song, Yan Bao, Wenwen Song, Jiao Liu, Courtney Lang, Kristen Jorgenson, Minyoung Jung, Dong Shen, Shasha Li, Ruirui Sun, Xu Ding, Jiao Yang, Xiao Meng, Ning Wang, Zhifang Yan, Yuhe Yan, Qian Kong, Ying Dong, Fangyuan Cui, Yiheng Tu, Bingnan Cui, Jian Kong
Chronic spontaneous urticaria (CSU) is a common itchy skin disease. Despite its prevalence, the neuropathology of CSU is uncertain. In this study, we explored resting state functional connectivity (rs-FC) changes in CSU, as well as how the symptom changes following intervention can modulate rs-FC. Forty patients and 40 healthy controls (HCs) were recruited. Following an intervention, 32 patients participated in a second scan approximately 6 weeks after the first scan. Compared with healthy controls, CSU subjects exhibited higher regional homogeneity (ReHo) values in the cerebellum, which were positively associated with urticaria activity scores over 7 days (UAS7) at baseline...
March 24, 2018: Cerebellum
https://www.readbyqxmd.com/read/29567359/validity-and-responsiveness-of-the-urticaria-activity-and-impact-measure-u-aim-a-new-patient-reported-tool
#20
Marcus Maurer, Susan D Mathias, Ross D Crosby, Yamina Rajput, James L Zazzali
BACKGROUND: Chronic spontaneous urticaria (CSU), also known as chronic idiopathic urticaria (CIU), may produce hives, itch, and angioedema. The Urticaria Activity and Impact Measure (U-AIM) is a newly developed 9-item patient-reported measure designed for use in routine clinical practice to assess CSU activity and impact over the previous 7 days. OBJECTIVE: To evaluate validity, responsiveness, and clinically meaningful change of the U-AIM. METHODS: Data from a 24-week open-label single-arm period of a randomized, placebo-controlled study of omalizumab were used to assess the psychometric properties of U-AIM items for itch, hives, and angioedema...
March 19, 2018: Annals of Allergy, Asthma & Immunology
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