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https://www.readbyqxmd.com/read/28551423/safety-and-predictors-of-next-day-discharge-after-elective-transfemoral-transcatheter-aortic-valve-replacement
#1
Sulaiman Rathore, Yevgeniy Latyshev, Sheree Emore, Joseph Rowe, Jason Foerst
OBJECTIVES: We sought to determine the predictors of next-day discharge (NDD) for selected patients undergoing elective transfemoral transcatheter aortic valve replacement (TF-TAVR). BACKGROUND: Techniques have rapidly evolved over the last several years to simplify TF-TAVR allowing for a subset of patients to be discharged the next day. METHODS: Baseline and procedural characteristics, in-hospital and 30-day follow-up outcomes, complications and readmission rates of 100 TF-TAVR cases were assessed...
May 19, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28551028/bidirectional-interactions-between-diabetes-and-alzheimer-s-disease
#2
REVIEW
Mitsuru Shinohara, Naoyuki Sato
Clinical studies have indicated that diabetes is associated with Alzheimer's disease (AD) and neurodegeneration. However, the mechanisms underlying this association have not been fully elucidated. Diabetes causes neurodegeneration by inducing changes in vascular function and structure, glucose metabolism, and insulin signaling, as well as by modifying β-amyloid (Aβ)/tau metabolisms. In turn, AD influences systemic glucose metabolism by inducing behavioral changes, memory disturbances, hypothalamic dysfunction, frailty and possibly plasma/peripheral Aβ level changes...
May 24, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28550996/web-based-health-interventions-for-family-caregivers-of-elderly-individuals-a-scoping-review
#3
REVIEW
Marina B Wasilewski, Jennifer N Stinson, Jill I Cameron
BACKGROUND: For the growing proportion of elders globally, aging-related illnesses are primary causes of morbidity causing reliance on family members for support in the community. Family caregivers experience poorer physical and mental health than their non-caregiving counterparts. Web-based interventions can provide accessible support to family caregivers to offset declines in their health and well-being. Existing reviews focused on web-based interventions for caregivers have been limited to single illness populations and have mostly focused on the efficacy of the interventions...
July 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28550693/healthcare-for-the-aging-citizen-and-the-aging-citizen-for-healthcare-involving-patient-advisors-in%C3%A2-elder-friendly-care-improvement
#4
Jennifer Verma, Patricia O'Connor, Jerold Hodge, Howard Abrams, Jocelyn Bennett, Samir Sinha
With an aging population and a healthcare system that is overly reliant on providing expensive and sometimes problematic hospital-based care for older Canadians, driving improvements that promote elder-friendly care has never been more critical. The Acute Care for Elders (ACE) Strategy at Toronto's Mount Sinai Hospital is the focus of a pan-Canadian collaborative delivered by the Canadian Foundation for Healthcare Improvement in partnership with the Canadian Frailty Network. The intent is to spread the ACE Strategy's elder-friendly models of care and practices to 18 participating healthcare delivery organizations...
2017: Healthcare Quarterly
https://www.readbyqxmd.com/read/28549839/vitamin-b12-deficiency-might-be-related-to-sarcopenia-in-older-adults
#5
Esra Ates Bulut, Pinar Soysal, Ali Ekrem Aydin, Ozge Dokuzlar, Suleyman Emre Kocyigit, Ahmet Turan Isik
Sarcopenia and dynapenia are related to repeated falls, mobility restriction, depression, frailty, increased mortality and morbidity. The aim of this study is to evaluate the relationship between vitamin B12 deficiency and sarcopenia in older adults. 403 patients, who attended to outpatient clinic and underwent comprehensive geriatric assessment, were included study. All cases' skeletal muscle mass (SMM), walking speed and hand grip strength were recorded by bioimpedance, 4meter walking test and hand dynamometer respectively...
May 23, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28549718/sarcopenia-is-associated-with-physical-and-mental-components-of-health-related-quality-of-life-in-older-adults
#6
Betty Manrique-Espinoza, Aarón Salinas-Rodríguez, Oscar Rosas-Carrasco, Luis Miguel Gutiérrez-Robledo, José Alberto Avila-Funes
OBJECTIVES: To estimate the association between sarcopenia and the health-related quality of life (HRQoL) among community-dwelling older adults. DESIGN: Cross-sectional analysis of a prospective cohort. SETTING: The Rural Frailty Study, a prospective study on the prevalence of frailty in rural settings in Mexico, with baseline and follow-up measurements conducted in 2009 and 2013, respectively. PARTICIPANTS: Five hundred forty-three men and women older than 70 years...
May 23, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28549703/integrated-care-enhancing-the-role-of-the-primary-health-care-professional-in-preventing-functional-decline-a-systematic-review
#7
REVIEW
John E Morley, Hidenori Arai, Li Cao, Birong Dong, Reshma A Merchant, Bruno Vellas, Renuka Visvanathan, Jean Woo
BACKGROUND: Although the older population is increasing worldwide, there is a marked deficit in the number of persons trained in geriatrics. It is now recognized that early detection and treatment of geriatric syndromes (frailty, sarcopenia, anorexia of aging, and cognitive decline) will delay or avert the development of disability. OBJECTIVES: To identify simple screening programs available for primary health professionals to identify geriatric syndromes. DATA SOURCES: PubMed for the last 5 years and study authors...
June 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28549083/a-comparison-of-two-mouse-frailty-assessment-tools
#8
Alice E Kane, Aniko Huizer-Pajkos, John Mach, Sarah J Mitchell, Rafael de Cabo, David G Le Couteur, Susan E Howlett, Sarah N Hilmer
The mouse clinical frailty index and the mouse frailty phenotype assessment are two recently developed tools used to assess frailty in mice. The objectives of this study were to investigate whether the same mice are identified as frail with both tools and to examine the association of each of the assessment tools with age and frailty-related outcomes. Frailty was measured using both tools in old (~24 months; n = 36) C57BL/6 male mice. After 2 weeks, blood pressure and heart rate were measured and serum samples were collected for analysis of alanine aminotransferase, creatinine, and albumin levels...
May 26, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28548972/assessment-of-adult-malnutrition-and-prognosis-with-bioelectrical-impedance-analysis-phase-angle-and-impedance-ratio
#9
Henry C Lukaski, Ursula G Kyle, Jens Kondrup
PURPOSE OF REVIEW: Malnutrition affects prognosis in many groups of patients. Although screening tools are available to identify adults at risk for poor nutritional status, a need exists to improve the assessment of malnutrition by identifying the loss of functional tissues that can lead to frailty, compromised physical function, and increased risk of morbidity and mortality, particularly among hospitalized and ill patients and older adults. Bioimpedance analysis (BIA) offers a practical approach to identify malnutrition and prognosis by assessing whole-body cell membrane quality and depicting fluid distribution for an individual...
May 25, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28547182/three-year-survival-of-art-high-viscosity-glass-ionomer-and-resin-composite-restorations-in-people-with-disability
#10
Gustavo F Molina, Denise Faulks, Ignacio Mazzola, Ricardo J Cabral, Jan Mulder, Jo E Frencken
OBJECTIVES: To assess the 3-year cumulative survival rate of atraumatic restorative treatment (ART) and conventional resin composite restorations (CRT) placed in persons with disability. MATERIALS AND METHODS: Patients referred for restorative care to the Haemophilia Foundation special care service were treated by one of two specialists. Patients and/or caregivers were provided with written and verbal information regarding treatment options and selected the alternative they preferred...
May 25, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28545062/association-of-frailty-status-with-acute-kidney-injury-and-mortality-after-transcatheter-aortic-valve-replacement-a-systematic-review-and-meta-analysis
#11
Charat Thongprayoon, Wisit Cheungpasitporn, Natanong Thamcharoen, Patompong Ungprasert, Wonngarm Kittanamongkolchai, Michael A Mao, Ankit Sakhuja, Kevin L Greason, Kianoush Kashani
OBJECTIVE: Frailty is a common condition in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). The aim of this systematic review was to assess the impact of frailty status on acute kidney injury (AKI) and mortality after TAVR. METHODS: A systematic literature search was conducted using MEDLINE, EMBASE, and Cochrane databases from the inception through November 2016. The protocol for this study is registered with PROSPERO (International Prospective Register of Systematic Reviews; no...
2017: PloS One
https://www.readbyqxmd.com/read/28544527/biomarkers-associated-with-mortality-in-patients-undergoing-dialysis
#12
Ana Rebollo Rubio, Jose Miguel Morales Asencio, Mª Eugenia Pons Raventos
BACKGROUND: Survival for patients commencing renal replacement therapy is around 90% in the first year and 83% at two years after starting dialysis. The factors that appear to predict mortality are comorbidity and frailty associated with kidney disease, glomerular filtration rate, age and biochemical factors. OBJECTIVES: To analyse the condition of patients starting renal replacement therapy, based on biomarkers commonly used in clinical practice and their association with mortality, measured 6 and 12 months after initiating replacement therapy...
May 23, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/28544338/alcohol-consumption-and-risk-of-unemployment-sickness-absence-and-disability-pension-in-denmark-a-prospective-cohort-study
#13
Maja Baeksgaard Jørgensen, Lau Caspar Thygesen, Ulrik Becker, Janne S Tolstrup
AIMS: We investigated the association between weekly alcohol consumption and binge drinking and the risk of unemployment, sickness absence and disability pension. DESIGN: Prospective register-based cohort study SETTING: Denmark PARTICIPANTS: A sample of 17,690 men and women, aged 18 to 60 years, from the Danish Health and Morbidity Survey in 2000, 2005 and 2010 participated in the study. Participants worked the entire year prior to baseline. MEASUREMENTS: Administrative registers were used to obtain information on unemployment, sickness absence and disability pension during a 5-year follow-up period...
May 21, 2017: Addiction
https://www.readbyqxmd.com/read/28543956/influence-of-frailty-on-the-quality-of-life-patients-qualified-for-pacemaker-implantation
#14
Agnieszka Mlynarska, Rafal Mlynarski, Krzysztof S Golba
AIMS AND OBJECTIVES: An important question is whether frailty syndrome affects the assessment of quality of life or whether frailty syndrome may reduce the benefits of a cardiac pacemaker implantation. BACKGROUND: Frailty syndrome is known risk factor for quality of life evaluation after selected cardiology invasive procedures. DESIGN: The study was designed as single center prospective study. METHODS: The study included 171 patients aged ≥ 60 years who were qualified for pacemaker implantation...
May 25, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28542531/new-diagnostic-index-for-sarcopenia-in-patients-with-cardiovascular-diseases
#15
Haruhito Harada, Hisashi Kai, Rei Shibata, Hiroshi Niiyama, Yasuhiro Nishiyama, Toyoaki Murohara, Noriko Yoshida, Atsushi Katoh, Hisao Ikeda
BACKGROUND: Sarcopenia is an aging and disease-related syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, with the risk of frailty and poor quality of life. Sarcopenia is diagnosed by a decrease in skeletal muscle index (SMI) and reduction of either handgrip strength or gait speed. However, measurement of SMI is difficult for general physicians because it requires special equipment for bioelectrical impedance assay or dual-energy X-ray absorptiometry...
2017: PloS One
https://www.readbyqxmd.com/read/28541400/identifying-frailty-in-the-emergency-department-feasibility-study
#16
Amy Elliott, Kay Phelps, Emma Regen, Simon Paul Conroy
Introduction: identifying the most at risk older people in Emergency Departments (EDs) may help guide clinical practice, and service improvement in emergency care, but little is known about how to implement such tools in practice. Methods: consensus building was used to determine the desirable characteristics of a risk stratification process, including focus groups and literature reviewing. Candidate tools were tested using clinical vignettes in semi-structured interviews with a range of clinicians working in one large ED, assessing speed of use, ease of use and agreement with clinical judgement...
May 25, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28541397/prevalence-and-co-occurrence-of-geriatric-syndromes-in-people-aged-75-years-and-older-in-france-results-from-the-bordeaux-three-city-study
#17
Maturin Tabue-Teguo, Leslie Grasset, José Alberto Avila-Funes, Robin Genuer, Cecile Proust-Lima, Karine Péres, Catherine Féart, Hélène Amieva, Magali González-Colaço Harmand, Catherine Helmer, Nathalie Salles, Muriel Rainfray, Jean François Dartigues
Background: Geriatric syndromes (GSs) are often the result of cumulative insults to multiple organ systems and are considered common in older adults. However, their frequency and co-occurrence are not well known in the elderly population. This study aimed to determine the prevalence of several GSs and to analyze the co-occurrence of these syndromes in a general population of elderly individuals. Methods: A cross-sectional analysis of 630 adults aged 75 years or older participating in the 10-year follow-up of the Bordeaux sample of the French Three-City Study was conducted...
May 24, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28541395/a-systematic-review-and-meta-analysis-of-prospective-associations-between-alcohol-consumption-and-incident-frailty
#18
Gotaro Kojima, Ann Liljas, Steve Iliffe, Stephen Jivraj, Kate Walters
Background: light-to-moderate alcohol consumption is protective against all-cause mortality and cardiovascular diseases. There is limited evidence in the literature on how alcohol consumption is related to frailty. Methods: five databases (Embase, Scopus, MEDLINE, CINAHL, PsycINFO) were systematically searched in July 2016 for prospective studies published between 2000 and 2016 examining baseline alcohol consumption and subsequent frailty risk among middle-aged or older community-dwelling population...
May 25, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28541176/more-human-than-human
#19
David Lawrence
Within the literature surrounding nonhuman animals on the one hand and cognitively disabled humans on the other, there is much discussion of where beings that do not satisfy the criteria for personhood fit in our moral deliberations. In the future, we may face a different but related problem: that we might create (or cause the creation of) beings that not only satisfy but exceed these criteria. The question becomes whether these are minimal criteria, or hierarchical, such that those who fulfill them to greater degree should be afforded greater consideration...
July 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28540538/impact-of-a-community-based-frailty-intervention-among-middle-aged-and-older-prefrail-and-frail-homeless-women-a-pilot-randomized-controlled-trial
#20
Benissa E Salem, Jennifer Ma-Pham, Stephanie Chen, Mary-Lynn Brecht, Anna Liza Antonio, Masha Ames
Interventions are needed to address frailty and other behaviors (e.g., drug and alcohol use) among prefrail and frail homeless women (P/FHW). The purpose of this pilot randomized controlled trial (RCT) was to compare the efficacy of a Frailty Intervention (FI) versus a Health Promotion (HP) program among P/FHW (N = 32). Structured instruments assessed sociodemographics, individual, situational, health-related, and behavioral factors. While program differences were not statistically significant with the main outcome variables, medium-to-large effect sizes were found in favor of the HP program as it relates to physical and overall frailty, as well as, any drug use, alcohol use, and drug dependency...
May 24, 2017: Community Mental Health Journal
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