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Frailty

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https://www.readbyqxmd.com/read/29792992/frailty-status-as-a-predictor-of-three-month-cognitive-and-functional-recovery-following-spinal-surgery-a-prospective-pilot-study
#1
Robert J Rothrock, Jeremy M Steinberger, Henry Badgery, Andrew C Hecht, Samuel K Cho, John M Caridi, Stacie Deiner
Background Context As increasing numbers of elderly Americans undergo spinal surgery, it is important to identify which patients are at highest risk for poor cognitive and functional recovery. Frailty is a geriatric syndrome which has been closely linked to poor outcomes, and short form screening may be a helpful tool for preoperative identification of at risk patients. Purpose To conduct a pilot study on the usefulness of a short-form screening tool to identify elderly patients at increased risk for prolonged cognitive and functional recovery following elective spine surgery...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792220/frailty-measurement-and-its-contribution-to-clinical-care-and-health-services-a-commentary
#2
Shannon Wu, Bruce Leff
Frailty is associated with poorer quality of life and higher healthcare utilization and spending. Despite its importance, no clear consensus exists on the definition of frailty. The recent IJHPR article by Buch et al. significantly contributes to the advancement of Israel's understanding of frailty by estimating for the first time the prevalence of frailty in the country. This commentary discusses the context of past and current advancements in measuring frailty and discusses how frailty measurement can contribute to both clinical care and the organization of health services to care for frail older adults in Israel and other developed countries...
May 23, 2018: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29789408/the-relationship-between-serum-igf-1-handgrip-strength-physical-performance-and-falls-in-elderly-men-and-women
#3
Caroline Van Nieuwpoort, Mariska Vlot, Laura Schaap, Paul Lips, Madeleine Drent
OBJECTIVE: Human aging is accompanied by a decrease in growth hormone secretion and serum IGF-1 levels. Also, loss of muscle mass, strength and impairment of physical performance, ending in a state of frailty, are seen in elderly. We aimed to investigate whether handgrip strength, physical performance and recurrent falls are related to serum IGF-1 levels in community dwelling elderly. DESIGN: Observational cohort study (cross-sectional and prospective). METHODS: We studied the association between IGF-1 and handgrip strength, physical performance and falls in participants of the Longitudinal Aging Study Amsterdam...
May 22, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29789139/medical-and-preoperative-evaluation-of-the-older-adult
#4
REVIEW
Audrey Chun
Because of age, increased rates of multimorbidity, polypharmacy, functional changes, and cognitive impairment, older adults are at higher risk for perioperative complications. Identifying modifiable risk factors and educating patients and families about what to expect can improve surgical outcomes and satisfaction. Comprehensive preoperative evaluation assesses these potential factors and should include recommendations for risk reduction. The optimal preoperative evaluation for older adults should address medical conditions and other areas pertinent to the care of older adults including assessments of cognition, capacity, delirium risk, function, frailty, nutrition, medications, and treatment preferences...
May 19, 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29788097/hypertension-treatment-for-older-people-navigating-between-scylla-and-charybdis
#5
Simon Paul Conroy, Rudi Gerardus Johannes Westendorp, Miles D Witham
Hypertension is a common condition in older people, but is often one of many conditions, particularly in frail older people, and so is rarely managed in isolation in the real world-which belies the bulk of the evidence upon which is treatment decisions are often based. In this article, we discuss the issues of ageing, including frailty and dementia, and their impact upon blood pressure management. We examine the evidence base for managing hypertension in older people, and explore some therapeutic ideas that might influence treatment decisions and strategies, including shared decision making...
May 21, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29788087/a-murine-frailty-index-based-on-clinical-and-laboratory-measurements-links-between-frailty-and-pro-inflammatory-cytokines-differ-in-a-sex-specific-manner
#6
Alice E Kane, Kaitlyn M Keller, Stefan Heinze-Milne, Scott A Grandy, Susan E Howlett
A frailty index based on clinical deficit accumulation (FI-Clinical) quantifies frailty in aging mice. We aimed to develop a laboratory test-based murine FI tool (FI-Lab) and to investigate the effects of age and sex on FI-Lab scores, FI-Clinical scores and the combination (FI-Combined), as well as to explore links between frailty and inflammation. Studies used older (17 & 23-months) C57BL/6 mice of both sexes. We developed an FI-Lab (blood pressure, blood chemistry, echocardiography) based on deviation from reference values in younger adults (12 months), which showed similar characteristics to a human FI-Lab tool...
May 18, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29788054/clinical-implications-of-asymptomatic-plasmodium-falciparum-infections-in-malawi
#7
Andrea G Buchwald, Alick Sixpence, Mabvuto Chimenya, Milius Damson, John D Sorkin, Mark L Wilson, Karl Seydel, Sarah Hochman, Don P Mathanga, Terrie E Taylor, Miriam K Laufer
Background: Asymptomatic Plasmodium falciparum infections are common in Malawi, however, the implications of these infections for the burden of malaria illness are unknown. Whether asymptomatic infections eventually progress to malaria illness, persist without causing symptoms, or clear spontaneously remains undetermined. We identified asymptomatic infections and evaluated the associations between persistent asymptomatic infections and malaria illness. Methods: Children and adults (N = 120) who presented at a health facility with uncomplicated malaria were followed monthly for two years...
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29788039/frailty-neurocognitive-impairment-or-both-in-predicting-poor-health-outcomes-among-adults-living-with-hiv
#8
Kristine M Erlandson, Jeremiah Perez, Mona Abdo, Kevin Robertson, Ronald J Ellis, Susan L Koletar, Robert Kalayjian, Babafemi Taiwo, Frank J Palella, Katherine Tassiopoulos
Background: Neurocognitive impairment (NCI) is strongly associated with frailty in people living with HIV (PLWH); the overlap of frailty and NCI, and the impact on health outcomes in PLWH is unknown. Methods: PLWH in a longitudinal, observational study of aging completed entry evaluations for frailty and NCI. Outcomes were falls (recurrent), increased limitations in independent activities of daily living, or mortality and were combined. Poisson regression models estimated prevalence ratios (PR) for ≥1 outcome over 2 years...
May 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29788032/tracking-changes-in-frailty-throughout-later-life-results-from-a-17-year-longitudinal-study-in-the-netherlands
#9
Emiel O Hoogendijk, Kenneth Rockwood, Olga Theou, Joshua J Armstrong, Bregje D Onwuteaka-Philipsen, Dorly J H Deeg, Martijn Huisman
Background: to better understand the development of frailty with ageing requires longitudinal studies over an extended time period. Objective: to investigate changes in the degree of frailty during later life, and the extent to which changes are determined by socio-demographic characteristics. Methods: six measurement waves of 1,659 Dutch older adults aged 65 years and over in the Longitudinal Aging Study Amsterdam (LASA) yielded 5,211 observations over 17 years...
May 19, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29787415/cooccurrence-of-post-intensive-care-syndrome-problems-among-406-survivors-of-critical-illness
#10
Annachiara Marra, Pratik P Pandharipande, Timothy D Girard, Mayur B Patel, Christopher G Hughes, James C Jackson, Jennifer L Thompson, Rameela Chandrasekhar, Eugene Wesley Ely, Nathan E Brummel
OBJECTIVES: To describe the frequency of cooccurring newly acquired cognitive impairment, disability in activities of daily livings, and depression among survivors of a critical illness and to evaluate predictors of being free of post-intensive care syndrome problems. DESIGN: Prospective cohort study. SETTING: Medical and surgical ICUs from five U.S. centers. PATIENTS: Patients with respiratory failure or shock, excluding those with preexisting cognitive impairment or disability in activities of daily livings...
May 21, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29785933/a-comparison-of-peripheral-imaging-technologies-for-bone-and-muscle-quantification-a-review-of-segmentation-techniques
#11
REVIEW
Andy Kin On Wong, Sarah Lynn Manske
Musculoskeletal science has developed many overlapping branches, necessitating specialists from 1 area of focus to often require the expertise in others. In terms of imaging, this means obtaining a comprehensive illustration of bone, muscle, and fat tissues. There is currently a lack of a reliable resource for end users to learn about these tissues' imaging and quantification techniques together. An improved understanding of these tissues has been an important progression toward better prediction of disease outcomes and better elucidation of their interaction with frailty, aging, and metabolic disorders...
April 17, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29785098/sarcopenia-assessment-of-disease-burden-and-strategies-to-improve-outcomes
#12
REVIEW
Ilaria Liguori, Gennaro Russo, Luisa Aran, Giulia Bulli, Francesco Curcio, David Della-Morte, Gaetano Gargiulo, Gianluca Testa, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete
Life expectancy is increasing worldwide, with a resultant increase in the elderly population. Aging is characterized by the progressive loss of skeletal muscle mass and strength - a phenomenon called sarcopenia. Sarcopenia has a complex multifactorial pathogenesis, which involves not only age-related changes in neuromuscular function, muscle protein turnover, and hormone levels and sensitivity, but also a chronic pro-inflammatory state, oxidative stress, and behavioral factors - in particular, nutritional status and degree of physical activity...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29784558/life-expectancy-in-elderly-patients-following-burns-injury
#13
Sarvnaz Sepehripour, Sirisha Duggineni, Somaya Shahsavari, Baljit Dheansa
INTRODUCTION: Burn injuries commonly occur in vulnerable age and social groups. Previous research has shown that frailty may represent a more important marker of adverse outcome in healthcare rather than chronological age (Roberts et al., 2012). In this paper we determined the relationship between burn injury, frailty, co-morbidities and long-term survival. METHODOLOGY: Retrospective data collection from patients aged 75 with burns injuries, treated and discharged at Queen Victoria Hospital...
May 18, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29783928/physical-activity-intervention-for-elderly-patients-with-reduced-physical-performance-after-acute-coronary-syndrome-hulk-study-rationale-and-design-of-a-randomized-clinical-trial
#14
Elisabetta Tonet, Elisa Maietti, Giorgio Chiaranda, Francesco Vitali, Matteo Serenelli, Giulia Bugani, Gianni Mazzoni, Rossella Ruggiero, Jonathan Myers, Giovanni Quinto Villani, Ursula Corvi, Giovanni Pasanisi, Simone Biscaglia, Rita Pavasini, Giulia Ricci Lucchi, Gianluigi Sella, Roberto Ferrari, Stefano Volpato, Gianluca Campo, Giovanni Grazzi
BACKGROUND: Reduced physical performance and impaired mobility are common in elderly patients after acute coronary syndrome (ACS) and they represent independent risk factors for disability, morbidity, hospital readmission and mortality. Regular physical exercise represents a means for improving functional capacity. Nevertheless, its clinical benefit has been less investigated in elderly patients in the early phase after ACS. The HULK trial aims to investigate the clinical benefit of an early, tailored low-cost physical activity intervention in comparison to standard of care in elderly ACS patients with reduced physical performance...
May 21, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29783237/-evaluation-on-changes-in-risk-of-spasm-of-accommodation-in-pupils-due-to-implementation-of-prevention-program
#15
Maryna O Starynets, Oleksandr M Ocheredko
OBJECTIVE: Introduction: Number of children with myopia increased 3-fold while those with spasm of accommodation followed a suit by 5-fold increase over last decade to some extend due to computerization. These tidings necessitate the development and implementation of primordial prevention programs. The aim was to evaluate the changes in risk of spasm of accommodation in pupils due to implementation of prevention program. PATIENTS AND METHODS: Materials and methods: Data collection was based on dynamic panel of pupils padding by first-formers over 2012-2015 and tracing up to 2017, sample size is 1115...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29781555/dependence-on-others-for-oral-hygiene-and-its-association-with-hand-deformities-and-functional-impairment-in-elders-with-a-history-of-leprosy
#16
Raquel Conceição Ferreira, Talita Xavier Gonçalves, Anna Rachel Dos Santos Soares, Luísa Rodrigues de Abreu Carvalho, Fernanda Lamounier Campos, Marco Túlio de Freitas Ribeiro, Andrea Maria Eleutério de Barros Lima Martins, Efigênia Ferreira E Ferreira
OBJECTIVE: To analyse the frequency of dependence on others for oral hygiene and its association with hand deformities, frailty and dependence on others for basic activities of daily living (BADL) among elders with a history of leprosy. BACKGROUND: Dependence on others for oral hygiene has not been considered in multifunctional geriatric assessments. MATERIAL AND METHODS: Edentulous elders with a history of leprosy who used complete dentures and resided in a former leprosy colony were classified as independent or partially/completely dependent on others for brushing their dentures or rinsing and for BADL, and as frail or robust...
May 21, 2018: Gerodontology
https://www.readbyqxmd.com/read/29778652/frailty-and-diabetes-among-mexican-american-older-adults
#17
Bret T Howrey, Soham Al Snih, Kyriakos S Markides, Kenneth J Ottenbacher
PURPOSE: Progressive physical frailty in older adults is associated with increased risk of falls, disability, institutionalization, and mortality. Although associations between diabetes and frailty have been observed, the impact of diabetes on frailty in older Hispanics is largely unexplored. We examine the association of diabetes on the odds of frailty among older Mexican Americans. METHODS: Using data from the Hispanic Established Population for the Epidemiological Study of the Elderly from 1995 until 2012, frailty was assessed by slow gait, weak hand grip strength, exhaustion, and unexplained weight loss (n = 1327)...
April 26, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29778642/benefits-of-a-multicomponent-falls-unit-based-exercise-program-in-older-adults-with-falls-in-real-life
#18
Rafael García Molina, Marta Carolina Ruíz Grao, Alicia Noguerón García, Marta Martínez Reig, Mariano Esbrí Víctor, Míkel Izquierdo Redín, Pedro Abizanda Soler
BACKGROUND/OBJECTIVES: Multicomponent exercise programs are the cornerstone in preventing gait and balance impairments and falls in older adults. However, the effects of these programs in usual clinical practice have been poorly analyzed. DESIGN: 4-Month, twice-a-week multicomponent exercise program cohort study in real-life. SETTING: Falls Unit, Complejo Hospitalario Universitario of Albacete, Spain. PARTICIPANTS: Sixty-seven participants who had experienced a fall in the previous year were included...
May 17, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29777975/geriatric-analysis-from-prodige-20-randomized-phase-ii-trial-evaluating-bevacizumab-chemotherapy-versus-chemotherapy-alone-in-older-patients-with-untreated-metastatic-colorectal-cancer
#19
T Aparicio, O Bouché, E Francois, F Retornaz, E Barbier, J Taieb, S Kirscher, P-L Etienne, R Faroux, F Khemissa Akouz, F El Hajbi, C Locher, Y Rinaldi, T Lecomte, S Lavau-Denes, M Baconnier, A Oden-Gangloff, D Genet, L Bedenne, E Paillaud
BACKGROUND: Older patients have frailty characteristics that impair the transposition of treatment results found in younger patients. Predictive factors are needed to help with treatment choices for older patients. The PRODIGE 20 study is a randomized phase II study that evaluated chemotherapy associated with bevacizumab (BEV) or not (CT) in patients aged 75 years or older. PATIENTS AND METHODS: Patients underwent a geriatric assessment at randomization and at each evaluation...
May 16, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29777549/frailty-risk-in-hospitalized-older-adults-with-and-without-diabetes-mellitus
#20
Deborah A Lekan, Thomas P McCoy
BACKGROUND: Research indicates that diabetes mellitus (DM) may be a risk factor for frailty and individuals with DM are more likely to be frail than individuals without DM, however, there is limited research in hospitalized older adults. OBJECTIVES: To determine the extent of frailty in hospitalized older adults with and without DM using a 16-item Frailty Risk Score (FRS) and assess the role of frailty in predicting 30-day rehospitalization, discharge to an institution, and in-hospital mortality...
May 18, 2018: Journal of Clinical Nursing
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