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https://www.readbyqxmd.com/read/28944598/dentition-status-and-frailty-in-community-dwelling-older-adults-a-5-year-prospective-cohort-study
#1
Masanori Iwasaki, Akihiro Yoshihara, Misuzu Sato, Kumiko Minagawa, Mieko Shimada, Mamoru Nishimuta, Toshihiro Ansai, Yutaka Yoshitake, Hideo Miyazaki
AIM: To examine the longitudinal association between dentition status and incidence of frailty in older adults. METHODS: The present prospective cohort study included community-dwelling Japanese adults aged 75 years at baseline (n = 322). Dental examinations, biochemical blood examinations, physical performance and anthropometric measurements, and structured questionnaires were carried out at baseline. The presence of ≥20 teeth with nine or more occluding pairs of teeth was defined as functional dentition...
September 24, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28943684/joint-scale-change-models-for-recurrent-events-and-failure-time
#2
Gongjun Xu, Sy Han Chiou, Chiung-Yu Huang, Mei-Cheng Wang, Jun Yan
Recurrent event data arise frequently in various fields such as biomedical sciences, public health, engineering, and social sciences. In many instances, the observation of the recurrent event process can be stopped by the occurrence of a correlated failure event, such as treatment failure and death. In this article, we propose a joint scale-change model for the recurrent event process and the failure time, where a shared frailty variable is used to model the association between the two types of outcomes. In contrast to the popular Cox-type joint modeling approaches, the regression parameters in the proposed joint scale-change model have marginal interpretations...
2017: Journal of the American Statistical Association
https://www.readbyqxmd.com/read/28943182/the-relationship-between-the-dietary-inflammatory-index-and-incident-frailty-a-longitudinal-cohort-study
#3
Nitin Shivappa, Brendon Stubbs, James R Hébert, Matteo Cesari, Patricia Schofield, Pinar Soysal, Stefania Maggi, Nicola Veronese
OBJECTIVE: Inflammation is key risk factor for several conditions in the elderly. However, the relationship between inflammation and frailty is still unclear. We investigated whether higher dietary inflammatory index (DII) scores were associated with higher incidence of frailty in a cohort of North Americans. DESIGN: Longitudinal, with a follow-up of 8 years. SETTING: Osteoarthritis Initiative. PARTICIPANTS: A total of 4421 participants with, or at high risk of, knee osteoarthritis...
September 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28943020/frailty-fantasia
#4
EDITORIAL
John E Morley
No abstract text is available yet for this article.
October 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28942563/polypharmacy-in-the-geriatric-oncology-population
#5
REVIEW
Lauren R Hersh, Kathryn Beldowski, Emily R Hajjar
PURPOSE OF REVIEW: This review explores the multiple definitions, epidemiology, and impact of polypharmacy in geriatric oncology patients. Risk factors and clinical implications of polypharmacy are delineated and potential clinical approaches to reduce polypharmacy are reviewed. RECENT FINDINGS: Most sources currently define polypharmacy as the administration of multiple medications that are non-essential, unnecessary, duplicative, or ineffective. Possible risk factors associated with polypharmacy in geriatric cancer patients include comorbid conditions, prescribing cascades, and hospitalization...
September 23, 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28942076/assessment-of-commonly-used-frailty-markers-for-high-and-extreme-risk-patients-undergoing-transcatheter-aortic-valve-replacement
#6
Jessica Forcillo, Jose F Condado, Yi-An Ko, Michael Yuan, Jose N Binongo, Nnaemeka M Ndubisi, John J Kelly, Vasilis Babaliaros, Robert A Guyton, Chandan Devireddy, Bradley G Leshnower, James P Stewart, Louis P Perrault, Paul Khairy, Vinod H Thourani
BACKGROUND: The effect of frailty on outcomes after transcatheter aortic valve replacement (TAVR) remains incompletely understood. The objective of this study was to evaluate the performance of four commonly used frailty markers as predictors of early and late outcomes among patients undergoing TAVR. METHODS: A review was performed of 361 high- and extreme-risk patients undergoing TAVR from 2011 to 2015. Four frailty variables were assessed: serum albumin (g/dL), 5-m walk (seconds), grip strength (kg), and Katz index of independence in activities of daily living...
September 21, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28941581/use-of-frailty-to-predict-survival-in-elderly-patients-with-early-stage-non-small-cell-lung-cancer-treated-with-stereotactic-body-radiation-therapy
#7
Idalid Franco, Yu-Hui Chen, Fallon Chipidza, Vishesh Agrawal, John Romano, Elizabeth Baldini, Aileen Chen, Yolonda Colson, Ying Hou, David Kozono, Jon Wee, Raymond Mak
OBJECTIVES: Frailty has been shown to increase morbidity and mortality independent of age, but studies are lacking in radiation oncology. This study evaluates a modified frailty index (mFI) in predicting overall survival (OS) and non-cancer death for Stage I/II [N0M0] Non-Small-Cell Lung Cancer (NSCLC) patients treated with Stereotactic Body Radiation Therapy (SBRT). MATERIALS AND METHODS: Medical records for all patients with Stage I/II NSCLC treated at our institution with SBRT from 2009 to 2014 were reviewed...
September 20, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28941552/race-sex-and-risk-factors-in-radiographic-worsening-of-knee-osteoarthritis
#8
Ernest R Vina, Di Ran, Erin L Ashbeck, Charles Ratzlaff, C Kent Kwoh
OBJECTIVES: Characterize radiographic worsening in knee osteoarthritis (KOA) by race and sex over 4 years and evaluate the role of established risk factors in observed race/sex differences. METHODS: Whites (WHs) (694 males and 929 females) and African-Americans (AAs) (92 males and 167 females) at risk for radiographic KOA were eligible. Cox shared frailty models were used to estimate race and sex group differences in radiographic worsening, defined by Kellgren-Lawrence (K-L) and OARSI joint space narrowing (JSN)...
August 31, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28941287/addition-of-albumin-to-traditional-risk-score-improved-prediction-of-mortality-in-individuals-undergoing-transcatheter-aortic-valve-replacement
#9
Yoni Grossman, Israel M Barbash, Paul Fefer, Ilan Goldenberg, Anat Berkovitch, Ehud Regev, Noam Fink, Sagit Ben-Zekry, Yafim Brodov, Alexander Kogan, Victor Guetta, Ehud Raanani, Amit Segev
OBJECTIVES: The ability of the Society of Thoracic Surgeons (STS) and European System for Cardiac Operative Risk Evaluation (EuroSCORE)-2 scores to predict outcomes after transcatheter aortic valve replacement (TAVR) is insufficient. Frailty and serum albumin as a frailty marker were shown to correlate with prognosis after TAVR. We sought to evaluate the additive value of serum albumin to STS and EuroSCORE-2 scores to predict mortality in individuals undergoing TAVR. DESIGN: Retrospective analysis...
September 23, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28941204/diabetes-related-fatigue
#10
EDITORIAL
Angela Shin-Yu Lien, Jawl-Shan Hwang, Yi-Der Jiang
Frequent complaint of fatigue for people with chronic condition is a strong predictor for functional limitations, disability, increasing mortality, and other adverse outcomes. With a high prevalence of diabetes in older people worldwide, fatigue symptoms, including frailty, muscle weakness, impaired mobility, functional limitation and loss of independence, are usually complained. Fatigue symptoms accompanied by the complications of neuromuscular dysfunction due to poor glycemic control, cardiovascular disease or peripheral vascular deficit were commonly shown for people with diabetes [1]...
September 22, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28940851/multidisciplinary-decision-making-regarding-chemotherapy-for-lung-cancer-patients-an-age-based-comparison
#11
K J G Schulkes, M E Hamaker, J-W J Lammers, M T M van Rens, M Geerts, L J R van Elden
Optimising decision-making in elderly patients is becoming increasingly urgent. We analysed treatment decisions and course of therapy for patients with lung cancer in different age categories: <65, 65-75, and 75 years and older. About 349 patients with lung cancer (median age 67.8 years), discussed at the multidisciplinary team meeting in the Diakonessenhuis Utrecht, the Netherlands, were reviewed. Multidisciplinary decision-making and subsequent clinical course were extracted from medical files. We found that 39% of eligible patients older than 75 years of age started treatment with chemotherapy compared to 80% of the younger patients (<65 and 65-75)...
September 21, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28940248/can-a-left-ventricular-assist-device-in-individuals-with-advanced-systolic-heart-failure-improve-or-reverse-frailty
#12
Mathew S Maurer, Evelyn Horn, Alex Reyentovich, Victoria Vaughan Dickson, Sean Pinney, Deena Goldwater, Nathan E Goldstein, Omar Jimenez, Sergio Teruya, Jeff Goldsmith, Stephen Helmke, Melana Yuzefpolskaya, Gordon R Reeves
BACKGROUND/OBJECTIVES: Frailty, characterized by low physiological reserves, is strongly associated with vulnerability to adverse outcomes. Features of frailty overlap with those of advanced heart failure, making a distinction between them difficult. We sought to determine whether implantation of a left ventricular assist device (LVAD) would decrease frailty. DESIGN: Prospective, cohort study. SETTING: Five academic medical centers. PARTICIPANTS: Frail individuals (N = 29; mean age 70...
September 21, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28940226/the-effect-of-leprotic-infection-on-the-risk-of-death-in-medieval-rural-denmark
#13
K Saige Kelmelis, Michael Holton Price, Jim Wood
INTRODUCTION: Paleopathological studies of leprosy in Danish skeletal collections show that many individuals suffered from this stigmatized disease during the Middle Ages. This study examines the risk of death associated with leprotic infection in individuals from the Danish rural cemetery of Øm Kloster (AD 1172-1536). Specifically, we modeled the influence of leprotic infection on age-specific mortality accounting also for sex and social status (lay person / monastic). MATERIALS AND METHODS: The sample consisted of 311 adult individuals from the Øm Kloster skeletal collection housed at the Institute of Forensic Medicine, University of Southern Denmark (ADBOU)...
September 22, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28938711/external-validation-of-the-claims-based-frailty-index-in-the-national-health-and-aging-trends-study-cohort
#14
Jodi B Segal, Jin Huang, David L Roth, Ravi Varadhan
No abstract text is available yet for this article.
September 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28937925/effect-of-self-reported-distress-thermometer-score-on-the-maximal-handgrip-and-pinch-strength-measurements-in-hemodialysis-patients
#15
Stephanie Camilleri, Stephanie Chong, Kamonwan Tangvoraphonkchai, Suree Yoowannakul, Andrew Davenport
BACKGROUND: Muscle weakness is a risk factor for mortality in hemodialysis (HD) patients. Muscle strength measurements are routinely used as a screening tool but depend on patient cooperation and motivation. We wished to determine whether measuring maximal voluntary muscle strength was affected by patient self-reported distress. METHODS: We measured pinch strength (PS) and handgrip strength (HGS) in 382 adult HD patients with a corresponding self-reported distress thermometer (DT) scores...
October 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28936626/the-impact-of-frailty-on-icu-and-30-day-mortality-and-the-level-of-care-in-very-elderly-patients-%C3%A2-%C3%A2-80%C3%A2-years
#16
Hans Flaatten, Dylan W De Lange, Alessandro Morandi, Finn H Andersen, Antonio Artigas, Guido Bertolini, Ariane Boumendil, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agwald Öhman, Bernardo Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, Andreas Valentin, Ximena Watson, Tilemachos Zaferidis, Bertrand Guidet
PURPOSE: Very old critical ill patients are a rapid expanding group in the ICU. Indications for admission, triage criteria and level of care are frequently discussed for such patients. However, most relevant outcome studies in this group frequently find an increased mortality and a reduced quality of life in survivors. The main objective was to study the impact of frailty compared with other variables with regards to short-term outcome in the very old ICU population. METHODS: A transnational prospective cohort study from October 2016 to May 2017 with 30 days follow-up was set up by the European Society of Intensive Care Medicine...
September 21, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28936613/chronic-inflammatory-demyelinating-polyradiculoneuropathy-and-anesthesia-a-case-series
#17
Andrew R Mortenson, Juraj Sprung, James C Watson, P James B Dyck, Toby N Weingarten
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired autoimmune demyelinating polyneuropathy characterized by symmetrical diffuse weakness that also can rarely affect bulbar and respiratory muscles. The study objective was to describe perioperative outcomes of patients with CIDP who received general anesthesia. This retrospective observational study evaluated patients with active (diagnosed or treated within the previous year) CIDP who underwent general anesthesia at our institution between January 1, 2010, and December 31, 2015...
September 21, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28936141/social-frailty-in-older-adults-a-scoping-review
#18
REVIEW
S Bunt, N Steverink, J Olthof, C P van der Schans, J S M Hobbelen
Social frailty is a rather unexplored concept. In this paper, the concept of social frailty among older people is explored utilizing a scoping review. In the first stage, 42 studies related to social frailty of older people were compiled from scientific databases and analyzed. In the second stage, the findings of this literature were structured using the social needs concept of Social Production Function theory. As a result, it was concluded that social frailty can be defined as a continuum of being at risk of losing, or having lost, resources that are important for fulfilling one or more basic social needs during the life span...
September 2017: European Journal of Ageing
https://www.readbyqxmd.com/read/28934150/frailty-and-its-contributory-factors-in-older-adults-a-comparison-of-two-asian-regions-hong-kong-and-taiwan
#19
Ruby Yu, Wan-Chi Wu, Jason Leung, Susan C Hu, Jean Woo
This study aimed to compare the prevalence of frailty across three Chinese populations: Hong Kong, Taiwan-urban and Taiwan-rural. Contributing factors to disparities in frailty were also examined. Data were derived from the Osteoporotic Fractures in Men (MrOs) and Women (MsOs) (Hong Kong) Study (n = 4000) and the Taiwan Longitudinal Study on Aging (n = 2392). Frailty was defined as an index calculated from 30 multiple deficits. The ratio of the frailty index to life expectancy at birth (FI/LE) was used as an indicator of compression of morbidity...
September 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28933993/gradual-physical-decline-characterises-the-illness-trajectories-of-care-home-residents
#20
Anne M Finucane, Barbara Stevenson, Scott A Murray
BACKGROUND: Three archetypal trajectories of physical decline have been identified: a short period of rapid decline; long-term limitations with intermittent acute periods; and a prolonged gradual decline. An understanding of illness trajectories can help clarify the evolving needs of people with progressive conditions, and inform the development of palliative care services to meet their needs. Many frail older people live and die in care homes; the present study is the first to explore the illness trajectories of residents in care home settings...
September 2, 2017: International Journal of Palliative Nursing
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