Hidehiro Itonaga, Adnan K Mookhtiar, Sarah M Greenblatt, Fan Liu, Concepcion Martinez, Daniel Bilbao, Masai Rains, Pierre-Jacques Hamard, Jun Sun, Afoma C Umeano, Stephanie Duffort, Chuan Chen, Na Man, Gloria Mas, Luca Tottone, Tulasigeri Totiger, Terrence Bradley, Justin Taylor, Stephan Schürer, Stephen D Nimer
An important epigenetic component of tyrosine kinase signaling is the phosphorylation of histones, and epigenetic readers, writers, and erasers. Phosphorylation of protein arginine methyltransferases (PRMTs), have been shown to enhance and impair their enzymatic activity. In this study, we show that the hyperactivation of Janus kinase 2 (JAK2) by the V617F mutation phosphorylates tyrosine residues (Y149 and Y334) in coactivator-associated arginine methyltransferase 1 (CARM1), an important target in hematologic malignancies, increasing its methyltransferase activity and altering its target specificity...
April 22, 2024: Nature Communications