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https://www.readbyqxmd.com/read/27936420/myofibroblastoma-of-the-male-breast-a-rare-entity-with-radiologic-pathologic-correlation
#1
John D Comer, Xiaoyan Cui, Carolyn Sharyn Eisen, Genevieve Abbey, Elizabeth Kagan Arleo
A 73-year old man with a history of multiple genitourinary malignancies was found to have a left retroareolar soft tissue mass on CT assessment of disease, and dedicated breast imaging was recommended. Diagnostic mammography and ultrasonography confirmed a solid mass, for which biopsy was recommended. Pathologic analysis demonstrated a spindle cell neoplasm with an immunoreactivity pattern consistent with myofibroblastoma. While this entity is benign, nonspecific imaging features necessitate tissue sampling for pathologic diagnosis, and, given pathologic rarity, open communication between the radiologist and pathologist is important to establish the correct diagnosis and to recommend appropriate management...
November 30, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27936414/-am-i-too-emotional-for-this-job-an-exploration-of-student-midwives-experiences-of-coping-with-traumatic-events-in-the-labour-ward
#2
Liz Coldridge, Sarah Davies
BACKGROUND: midwifery is emotionally challenging work, and learning to be a midwife brings its own particular challenges. For the student midwife, clinical placement in a hospital labour ward is especially demanding. In the context of organisational tensions and pressures the experience of supporting women through the unpredictable intensity of the labour process can be a significant source of stress for student midwives. Although increasing attention is now being paid to midwives' traumatic experiences and wellbeing few researchers have examined the traumatic experiences of student midwives...
November 28, 2016: Midwifery
https://www.readbyqxmd.com/read/27936224/change-in-serum-bilirubin-level-as-a-predictor-of-incident-metabolic-syndrome
#3
You-Bin Lee, Seung-Eun Lee, Ji Eun Jun, Jae Hwan Jee, Ji Cheol Bae, Sang-Man Jin, Jae Hyeon Kim
AIM: Serum bilirubin level was negatively associated with the prevalence of metabolic syndrome (MetS) in previous cross-sectional studies. However, bilirubin variance preceding the development of MetS has yet to be investigated. We aimed to determine the effect of change in bilirubin concentration on the risk of incident MetS in healthy Korean adults. METHODS: We conducted a retrospective longitudinal study of subjects who had undergone at least four yearly health check-ups between 2006 and 2012...
2016: PloS One
https://www.readbyqxmd.com/read/27935930/acute-ischemic-stroke-and-acute-on-chronic-kidney-disease
#4
R A Aftab, A H Khan, H A AbdulRazzaq, A S Adnan
Ischemic stroke is due to either local thrombus formation or emboli that occlude a cerebral artery, together with chronic kidney disease represent major mortality and morbidity.Here we present a case of 53 years old Malay man, admitted to a hospital in Malaysia complaining of sudden on set of weakness on right sided upper and lower limb associated with slurred speech. Patient was also suffering from uncontrolled hypertension, hyperlipidemia, chronic kidney disease stage 4, and diabetes mellitus (uncontrolled)...
April 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935909/exploring-the-diagnosis-and-management-of-bouveret-s-syndrome
#5
M Bhattarai, P Bansal, B Patel, A Lalos
Bouveret's syndrome is an unusual cause of gastric outlet obstruction secondary to gallstone impaction. It is so rare that it is commonly missed in clinical practice if it is not considered in differential diagnoses of intestinal obstruction more specifically in man who does not report the history of gall stone. Furthermore, there are no definitive guidelines on approach and management of this condition. We present a seventy eight year old man who developed acute abdominal symptoms due to impaction of a gallstone in the duodenum...
January 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935830/photo-quiz-a-man-with-lymphadenopathy-and-lethargy
#6
EDITORIAL
Xiaoxia Hu, Yi Sun, Xinxin Xia, Lili Xu, Bihe Min, Daoyin Zhou, Libing Wang, Hui Wang, Ziguang Niu, Miaoxia He, Jianmin Wang, Anmei Deng, Jianmin Yang
No abstract text is available yet for this article.
November 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27935624/multiple-papules-in-a-chinese-man
#7
J Zheng, T Ye, Y Shao, B Yu, X Dou
No abstract text is available yet for this article.
December 9, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27935449/multiple-hook-fixation-in-revision-spinal-deformity-surgery-for-patients-with-a-previous-multilevel-fusion-mass-technical-note-and-preliminary-outcomes
#8
Ning Liu, Kirkham B Wood
OBJECTIVE A previous multilevel fusion mass encountered during revision spinal deformity surgery may obscure anatomical landmarks, making instrumentation unworkable or incurring substantial blood loss and operative time. This study introduced a surgical technique of multiple-hook fixation for fixating previous multilevel fusion masses in revision spinal deformity surgeries and then evaluated its outcomes. METHODS Patients with a previous multilevel fusion mass who underwent revision corrective surgery down to the lumbosacral junction were retrospectively studied...
December 9, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27935285/mechanical-testing-of-engineered-spider-silk-filaments-provides-insights-into-molecular-features-on-a-meso-scale
#9
Gregor Lang, Benedikt Richard Neugirg, Daniel Kluge, Andreas Fery, Thomas Scheibel
Spider dragline silk shows the highest toughness in comparison to all other known natural or man-made fibers. Despite a broad experimental foundation concerning the macroscopic silk thread properties as well as a thorough simulation-based molecular understanding, the impact of the mesoscale building blocks, namely nano-/submicron-sized filaments, on the mechanical properties of the threads remains the missing link. Here, we illustrate the function of these meso-scaled building blocks using electrospun fibers made of a recombinant spider silk protein and show the impact of β-sheet content and fiber hydration on their mechanical performance...
December 9, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27935236/ocular-traumas-in-working-age-adults-in-finland-helsinki-ocular-trauma-study
#10
Ahmad Sahraravand, Anna-Kaisa Haavisto, Juha M Holopainen, Tiina Leivo
PURPOSE: To describe epidemiology, causes, treatments and outcomes of ocular injuries in adults aged 17 to 60 in southern Finland. METHODS: All new ocular trauma patients admitted to the Helsinki University Eye Hospital (HUEH), during 1 year in 2011-2012. The data were from hospital records and prospectively from patient questionnaires. The follow-up time was 3 months. RESULTS: The incidence for ocular injury was 88/100 000/year. From 831 trauma patients, 80% were men, 34% were work-related injuries, and 11% were assaults...
December 9, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27935197/ring-expansion-approach-to-medium-sized-lactams-and-analysis-of-their-medicinal-lead-like-properties
#11
Laetitia G Baud, Morgan Ann Manning, Helen L Arkless, Thomas C Stephens, William Paul Unsworth
Medium-sized rings are widely considered to be under-represented in biological screening libraries for lead identification in medicinal chemistry. To help address this, a library of medium-sized lactams has been generated using a simple, scalable and versatile ring expansion protocol. Analysis of the library using open access computational tool LLAMA suggests that these lactams and their derivatives have highly promising physicochemical and 3D spatial properties and thus have much potential in drug discovery...
December 9, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27935140/three-dimensional-metal-organic-framework-as-super-heat-resistant-explosive-potassium-4-5-amino-3-nitro-1h-1-2-4-triazol-1-yl-3-5-dinitropyrazole
#12
Chuan Li, Man Zhang, Qishan Chen, Yingying Li, Huiqi Gao, Wei Fu, Zhiming Zhou
A novel energetic super heat-resistant explosive, potassium 4-(5-amino-3-nitro-1H-1,2,4-triazol-1-yl)-3,5-dinitropyrazole (KCPT, 1), featuring a three-dimensional (3D) metal-organic framework (MOF) was synthesized and fully characterized. The new 3D MOF was found to be extremely heat-resistant, having a high decomposition temperature of 323 °C. In addition, KCPT exhibits the best calculated detonation performance (vD = 8457 m s-1, P = 32.5 GPa) among the reported super heat-resistant explosives or energetic potassium salts while retaining a suitable impact sensitivity of 7...
December 9, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27935128/nonlinear-frameworks-for-reversible-and-pluripotent-wetting-on-topographic-surfaces
#13
Junsoo Kim, Yifan Wang, Hyunchul Park, Min Cheol Park, Seung Eon Moon, Soon Man Hong, Chong Min Koo, Kahp-Yang Suh, Shu Yang, Hyesung Cho
Soft, ultrathin frameworks nonlinearly organized in tandem are presented to realize both reversible and pluripotent wetting on topographic surfaces. A design rule is introduced by establishing and proving the theoretical model upon hierarchical textures. Nonlinear frameworks can be conformally and reversibly wet upon complex topography in nature, thereby overcoming the wetting problems in previous conventional solid systems.
December 9, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27934201/relation-between-natural-and-practical-ligand-binding-constants-strong-implications-for-extraction-of-molecular-level-information-from-the-temperature-dependence-of-ligand-binding-equilibria
#14
https://www.readbyqxmd.com/read/27934125/quantitatively-monitoring-the-size-focusing-of-au-nanoclusters-and-revealing-what-promotes-the-size-transformation-from-au44-tbbt-28-to-au36-tbbt-24
#15
Lingwen Liao, Chuanhao Yao, Chengming Wang, Shubo Tian, Jishi Chen, Man-Bo Li, Nan Xia, Nan Yan, Zhikun Wu
"Size-focusing" is a well-recognized process and widely employed for the synthesis of atomically monodisperse metal nanoclusters. However, quantitatively monitoring the size-focusing of Au nanoclusters has not been achieved yet, and the in-depth understanding of the size focusing is far from completed. Herein, we introduce a facile, cheap, and powerful tool, preparative thin-layer chromatography (PTLC), to quantitatively track the size-focusing process, to reveal that mainly ∼3 nm nanoparticles promote the transformation from Au44(TBBT)28 to Au36(TBBT)24 (where TBBT is 4-tert-butylbenzenethiolate) and to improve the syntheses of Au44(TBBT)28 and Au36(TBBT)24...
December 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27934105/simultaneous-analysis-of-free-and-sulfated-steroids-by-liquid-chromatography-mass-spectrometry-with-selective-mass-spectrometric-scan-modes-and-polarity-switching
#16
Su Hyeon Lee, Nanhee Lee, Youngmin Hong, Bong Chul Chung, Man Ho Choi
Sulfated steroids can act as a latent form of active free steroids, coexisting with them in biological specimens. To evaluate the metabolic significance of free and sulfated steroid species, a simultaneous analysis of eight free steroids [cholesterol, pregnenolone, 17α-hydroxypregnenolone, progesterone, 17α-hydroxyprogesterone, dehydroepiandrosterone (DHEA), testosterone, and 17β-estradiol] and four biologically relevant sulfated steroids was developed and validated, using selected-ion and multiple-reaction monitoring modes coupled to polarity-switching liquid chromatography/mass spectrometry (LC/MS)...
December 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27933781/structure-and-function-of-the-hepatitis-c-virus-envelope-glycoproteins-e1-and-e2-antiviral-and-vaccine-targets
#17
Holly Freedman, Michael R Logan, John Lok Man Law, Michael Houghton
The hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are critical in viral attachment and cell fusion, and studies of these proteins may provide valuable insights into their potential uses in vaccines and antiviral strategies. Progress has included elucidating the crystal structures of portions of their ectodomains, as well as many other studies of hypervariable regions, stem regions, glycosylation sites, and the participation of E1/E2 in viral fusion with the endosomal membrane. The available structural data have shed light on the binding sites of cross-neutralizing antibodies...
November 11, 2016: ACS Infectious Diseases
https://www.readbyqxmd.com/read/27933676/white-matter-hyperintensities-are-associated-with-disproportionate-progressive-hippocampal-atrophy
#18
Cassidy M Fiford, Emily N Manning, Jonathan W Bartlett, David M Cash, Ian B Malone, Gerard R Ridgway, Manja Lehmann, Kelvin K Leung, Carole Sudre, Sebastien Ourselin, Geert Jan Biessels, Owen T Carmichael, Nick C Fox, M Jorge Cardoso, Josephine Barnes
This study investigates relationships between white matter hyperintensity (WMH) volume, cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathology markers, and brain and hippocampal volume loss. Subjects included 198 controls, 345 Mild Cognitive Impairment (MCI) and 154 AD subjects with serial volumetric 1.5T MRI. CSF Aβ42 and total tau were measured (n=353). Brain and hippocampal loss were quantified from serial MRI using the Boundary Shift Integral (BSI). Multiple linear regression models assessed the relationships between WMHs and hippocampal and brain atrophy rates...
December 9, 2016: Hippocampus
https://www.readbyqxmd.com/read/27933631/hemicrania-continua-like-headache-related-to-transdermal-nitroglycerine-therapy
#19
Federico Mainardi, Giorgio Zanchin, Ferdinando Maggioni
Several cases of symptomatic hemicrania continua (HC) have been reported. A 66-year-old man, suffering from migraine without aura, presented with a four month history of a new headache fulfilling the ICHD 3beta clinical criteria for HC. HC onset was strictly related to the use of transdermal nitroglycerine patch (TNP). In agreement with the cardiologist, TNP was discontinued and the headache promptly disappeared; symptoms reappeared within 6-12 hours after nitroglycerine reintroduction. After permanent discontinuation of TNP, headache disappeared at one year follow-up...
December 9, 2016: Headache
https://www.readbyqxmd.com/read/27933404/genome-wide-high-content-sirna-screening-identifies-the-alzheimer-s-genetic-risk-factor-fermt2-as-a-major-modulator-of-app-metabolism
#20
Julien Chapuis, Amandine Flaig, Benjamin Grenier-Boley, Fanny Eysert, Virginie Pottiez, Gaspard Deloison, Alexandre Vandeputte, Anne-Marie Ayral, Tiago Mendes, Shruti Desai, Alison M Goate, John S K Kauwe, Florence Leroux, Adrien Herledan, Florie Demiautte, Charlotte Bauer, Fréderic Checler, Ronald C Petersen, Kaj Blennow, Henrik Zetterberg, Lennart Minthon, Vivianna M Van Deerlin, Virginia Man-Yee Lee, Leslie M Shaw, John Q Trojanowski, Marilyn Albert, Abhay Moghekar, Richard O'Brien, Elaine R Peskind, Nicolas Malmanche, Gerard D Schellenberg, Pierre Dourlen, Ok-Ryul Song, Carlos Cruchaga, Philippe Amouyel, Benoit Deprez, Priscille Brodin, Jean-Charles Lambert
Genome-wide association studies (GWASs) have identified 19 susceptibility loci for Alzheimer's disease (AD). However, understanding how these genes are involved in the pathophysiology of AD is one of the main challenges of the "post-GWAS" era. At least 123 genes are located within the 19 susceptibility loci; hence, a conventional approach (studying the genes one by one) would not be time- and cost-effective. We therefore developed a genome-wide, high-content siRNA screening approach and used it to assess the functional impact of gene under-expression on APP metabolism...
December 8, 2016: Acta Neuropathologica
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