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https://www.readbyqxmd.com/read/26883379/antibiotic-cross-resistance-in-the-lab-and-resistance-co-occurrence-in-the-clinic-discrepancies-and-implications-in-e-coli
#1
Uri Obolski, Eynat Dellus-Gur, Gideon Y Stein, Lilach Hadany
INTRODUCTION: Antibiotic resistance is an important public health issue, and vast resources are invested in researching new ways to fight it. Recent experimental works have shown that resistance to some antibiotics can result in increased susceptibility to others, namely induce cross-sensitivity. This phenomenon could be utilized to increase efficiency of antibiotic treatment strategies that minimize resistance. However, as conditions in experimental settings and in the clinic may differ substantially, the implications of cross-sensitivity for clinical settings are not guaranteed and should be examined...
June 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/26004540/negative-epistasis-and-evolvability-in-tem-1-%C3%AE-lactamase-the-thin-line-between-an-enzyme-s-conformational-freedom-and-disorder
#2
Eynat Dellus-Gur, Mikael Elias, Emilia Caselli, Fabio Prati, Merijn L M Salverda, J Arjan G M de Visser, James S Fraser, Dan S Tawfik
Epistasis is a key factor in evolution since it determines which combinations of mutations provide adaptive solutions and which mutational pathways toward these solutions are accessible by natural selection. There is growing evidence for the pervasiveness of sign epistasis--a complete reversion of mutational effects, particularly in protein evolution--yet its molecular basis remains poorly understood. We describe the structural basis of sign epistasis between G238S and R164S, two adaptive mutations in TEM-1 β-lactamase--an enzyme that endows antibiotics resistance...
July 17, 2015: Journal of Molecular Biology
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