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https://www.readbyqxmd.com/read/27906174/therapeutic-advantage-of-pro-electrophilic-drugs-to-activate-the-nrf2-are-pathway-in-alzheimer-s-disease-models
#1
Stuart A Lipton, Tayebeh Rezaie, Anthony Nutter, Kevin M Lopez, James Parker, Kunio Kosaka, Takumi Satoh, Scott R McKercher, Eliezer Masliah, Nobuki Nakanishi
Alzheimer's disease (AD) is characterized by synaptic and neuronal loss, which occurs at least partially through oxidative stress induced by oligomeric amyloid-β (Aβ)-peptide. Carnosic acid (CA), a chemical found in rosemary and sage, is a pro-electrophilic compound that is converted to its active form by oxidative stress. The active form stimulates the Keap1/Nrf2 transcriptional pathway and thus production of phase 2 antioxidant enzymes. We used both in vitro and in vivo models. For in vitro studies, we evaluated protective effects of CA on primary neurons exposed to oligomeric Aβ...
December 1, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27878523/intravenous-ketamine-for-subacute-treatment-of-refractory-chronic-migraine-a-case-series
#2
Clinton Lauritsen, Santiago Mazuera, Richard B Lipton, Sait Ashina
BACKGROUND: Refractory migraine is a challenging condition with great impact on health related quality of life. Intravenous (IV) ketamine has been previously used to treat various refractory pain conditions. We present a series of patients with refractory migraine treated with intravenous ketamine in the hospital setting. METHODS: Based on retrospective chart review, we identified six patients with refractory migraine admitted from 2010 through 2014 for treatment with intravenous ketamine...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27873122/how-well-does-the-ichd-3-beta-help-in-real-life-migraine-diagnosis-and-management
#3
REVIEW
Sait Ashina, Jes Olesen, Richard B Lipton
Classification has played a major role in the diagnosis of primary headache conditions including migraine with and without aura. With many updates and changes, the International Classification of Headache Disorders (ICHD)-3 beta is currently considered as the gold standard for classification of migraine and other headaches. Correct diagnosis of migraine and its subtypes is a first step toward appropriate treatment and crucial to minimizing disability and optimizing health-related quality of life. The ICHD-3 beta version represents the state of the art in migraine diagnosis but is expected to evolve as biological knowledge advances...
December 2016: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/27872221/donald-h-gilden-md-1937-2016
#4
Kenneth L Tyler, Howard L Lipton
No abstract text is available yet for this article.
November 22, 2016: Neurology
https://www.readbyqxmd.com/read/27861837/cardiovascular-events-conditions-and-procedures-among-people-with-episodic-migraine-in-the-us-population-results-from-the-american-migraine-prevalence-and-prevention-ampp-study
#5
Dawn C Buse, Michael L Reed, Kristina M Fanning, Tobias Kurth, Richard B Lipton
BACKGROUND: Though migraine, particularly migraine with aura, is a cardiovascular (CV) risk factor, the scope and distribution of cardiovascular disease in representative samples of people with migraine are not known. This is important because many widely used acute migraine treatments, including triptans, ergot alkaloids, and nonsteroidal anti-inflammatory drugs, carry precautions, warnings, or contraindications for use in persons with CV disease. OBJECTIVES: To assess the scope and distribution of cardiovascular events, conditions, and procedures in persons with episodic migraine in a representative sample of the US population, using data from the American Migraine Prevalence and Prevention (AMPP) Study...
November 12, 2016: Headache
https://www.readbyqxmd.com/read/27861179/cognitive-impairment-and-dementia-in-older-adults-with-chronic-kidney-disease-a-review
#6
Andrea R Zammit, Mindy J Katz, Markus Bitzer, Richard B Lipton
Individuals with chronic kidney disease (CKD), especially older adults, are at more risk of experiencing cognitive impairment, possibly leading to mild cognitive impairment and/or dementia. Studies report associations between CKD and cognitive impairment; although unclear, there seems to be a graded association between stage of CKD and affected cognitive domains, with executive function being affected earlier in the process than episodic memory and global ability. In CKD, dysexecutive mild cognitive impairment and vascular dementia are also more prominent than other subtypes...
October 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27851977/impaired-mitochondrial-dynamics-and-mitophagy-in-neuronal-models-of-tuberous-sclerosis-complex
#7
Darius Ebrahimi-Fakhari, Afshin Saffari, Lara Wahlster, Alessia DiNardo, Daria Turner, Tommy L Lewis, Christopher Conrad, Jonathan M Rothberg, Jonathan O Lipton, Stefan Kölker, Georg F Hoffmann, Min-Joon Han, Franck Polleux, Mustafa Sahin
No abstract text is available yet for this article.
November 15, 2016: Cell Reports
https://www.readbyqxmd.com/read/27837174/growth-of-headache-research-a-1983-2014-bibliometric-study
#8
REVIEW
Claude Robert, Concepción S Wilson, Richard B Lipton, Charles-Daniel Arreto
AIM: This study charts the growth of the scientific journal literature on headache for 30+ years (1983-2014). METHODS: Using the Web of Science, articles published in four two-year periods (1983-1984, 1993-1994, 2003-2004, 2013-2014) from journals indexed in the Science Citation Index Expanded database were retrieved and analyzed. RESULTS: From 1983-1984 to 2013-2014, the scientific literature on headache increased nearly fourfold (3.8) from 468 to 1776 articles; the number of participating countries more than doubled (26 to 67); and the two most prolific countries in each period were the USA and Italy...
November 11, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27822545/proteome-remodeling-in-response-to-sulfur-limitation-in-candidatus-pelagibacter-ubique
#9
Daniel P Smith, Carrie D Nicora, Paul Carini, Mary S Lipton, Angela D Norbeck, Richard D Smith, Stephen J Giovannoni
The alphaproteobacterium "Candidatus Pelagibacter ubique" strain HTCC1062 and most other members of the SAR11 clade lack genes for assimilatory sulfate reduction, making them dependent on organosulfur compounds that occur naturally in seawater. To investigate how these cells adapt to sulfur limitation, batch cultures were grown in defined medium containing either limiting or nonlimiting amounts of dimethylsulfoniopropionate (DMSP) as the sole sulfur source. Protein and mRNA expression were measured before, during, and after the transition from exponential growth to stationary phase...
July 2016: MSystems
https://www.readbyqxmd.com/read/27821734/role-of-sulfiredoxin-as-a-peroxiredoxin-2-denitrosylase-in-human-ipsc-derived-dopaminergic-neurons
#10
Carmen R Sunico, Abdullah Sultan, Tomohiro Nakamura, Nima Dolatabadi, James Parker, Bing Shan, Xuemei Han, John R Yates, Eliezer Masliah, Rajesh Ambasudhan, Nobuki Nakanishi, Stuart A Lipton
Recent studies have pointed to protein S-nitrosylation as a critical regulator of cellular redox homeostasis. For example, S-nitrosylation of peroxiredoxin-2 (Prx2), a peroxidase widely expressed in mammalian neurons, inhibits both enzymatic activity and protective function against oxidative stress. Here, using in vitro and in vivo approaches, we identify a role and reaction mechanism of the reductase sulfiredoxin (Srxn1) as an enzyme that denitrosylates (thus removing -SNO) from Prx2 in an ATP-dependent manner...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27805278/characterization-of-oil-and-water-accommodated-fractions-used-to-conduct-aquatic-toxicity-testing-in-support-of-the-deepwater-horizon-oil-spill-natural-resource-damage-assessment
#11
Heather P Forth, Carys L Mitchelmore, Jeffrey M Morris, Joshua Lipton
The Deepwater Horizon blowout resulted in the release of millions of barrels of crude oil. As part of the Trustees' Natural Resource Damage Assessment (NRDA), a testing program was implemented to evaluate the toxicity of DWH oil and oil/dispersant mixtures to aquatic organisms from the Gulf of Mexico. Because of the variety of exposures that likely occurred, the program included 4 DWH oils, which encompassed a range of weathering states, and 3 different oil-in-water mixing methods, for a total of 12 unique water accommodated fractions (WAFs)...
November 2, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27790103/a-voxel-based-morphometry-study-reveals-local-brain-structural-alterations-associated-with-ambient-fine-particles-in-older-women
#12
Ramon Casanova, Xinhui Wang, Jeanette Reyes, Yasuyuki Akita, Marc L Serre, William Vizuete, Helena C Chui, Ira Driscoll, Susan M Resnick, Mark A Espeland, Jiu-Chiuan Chen, Sylvia Wassertheil-Smoller, Mimi Goodwin, Richard DeNise, Michael Lipton, James Hannigan, Anthony Carpini, David Noble, Wilton Guzman, Jane Morley Kotchen, Joseph Goveas, Diana Kerwin, John Ulmer, Steve Censky, Troy Flinton, Tracy Matusewic, Robert Prost, Marcia L Stefanick, Sue Swope, Anne Marie Sawyer-Glover, Susan Hartley, Rebecca Jackson, Rose Hallarn, Bonnie Kennedy, Jill Bolognone, Lindsay Casimir, Amanda Kochis, John Robbins, Sophia Zaragoza, Cameron Carter, John Ryan, Denise Macias, Jerry Sonico, Lauren Nathan, Barbara Voigt, Pablo Villablanca, Glen Nyborg, Sergio Godinez, Adele Perrymann, Marian Limacher, Sheila Anderson, Mary Ellen Toombs, Jeffrey Bennett, Kevin Jones, Sandy Brum, Shane Chatfield, Kevin Vantrees, Jennifer Robinson, Candy Wilson, Kevin Koch, Suzette Hart, Jennifer Carroll, Mary Cherrico, Judith Ockene, Linda Churchill, Douglas Fellows, Anthony Serio, Sharon Jackson, Deidre Spavich, Karen Margolis, Cindy Bjerk, Chip Truwitt, Margaret Peitso, Alexa Camcrena, Richard Grim, Julie Levin, Mary Perron, Robert Brunner, Ross Golding, Leslie Pansky, Sandie Arguello, Jane Hammons, Nikki Peterson, Carol Murphy, Maggie Morgan, Mauricio Castillo, Thomas Beckman, Benjamin Huang, Lewis Kuller, Pat McHugh, Carolyn Meltzer, Denise Davis, Joyce Davis, Piera Kost, Kim Lucas, Tom Potter, Lee Tarr, Sally Shumaker, Mark Espeland, Laura Coker, Jeff Williamson, Debbie Felton, LeeAnn Gleiser, Steve Rapp, Claudine Legault, Maggie Dailey, Ramon Casanova, Julia Robertson, Patricia Hogan, Sarah Gaussoin, Pam Nance, Cheryl Summerville, Ricardo Peral, Josh Tan, Nick Bryan, Christos Davatzikos, Lisa Desiderio, Neil Buckholtz, Susan Molchan, Susan Resnick, Jacques Rossouw, Linda Pottern
Objective: Exposure to ambient fine particulate matter (PM2.5: PM with aerodynamic diameters < 2.5 μm) has been linked with cognitive deficits in older adults. Using fine-grained voxel-wise analyses, we examined whether PM2.5 exposure also affects brain structure. Methods: Brain MRI data were obtained from 1365 women (aged 71-89) in the Women's Health Initiative Memory Study and local brain volumes were estimated using RAVENS (regional analysis of volumes in normalized space). Based on geocoded residential locations and air monitoring data from the U...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27789277/erratum-to-filgrastim-stimulated-bone-marrow-compared-with-filgrastim-mobilized-peripheral-blood-in-myeloablative-sibling-allografting-for-patients-with-hematologic-malignancies-a-randomized-canadian-blood-and-marrow-transplant-group-study-biol-blood-marrow
#13
Stephen Couban, Mahmoud Aljurf, Sylvie Lachance, Irwin Walker, Cynthia Toze, Morel Rubinger, Jeffrey H Lipton, Stephanie J Lee, Jeff Szer, Richard Doocey, Ian D Lewis, Lothar Huebsch, Kang Howson-Jan, Michel Lalancette, Fahad Almohareb, Nadeem Chaudhri, Sabine Ivison, Raewyn Broady, Megan Levings, Diane Fairclough, Gerald Devins, David Szwajcer, Ronan Foley, Clayton Smith, Tony Panzarella, Holly Kerr, Amina Kariminia, Kirk R Schultz
No abstract text is available yet for this article.
October 24, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27788599/validation-and-calibration-of-headcount-a-self-report-measure-for-quantifying-heading-exposure-in-soccer-players
#14
E Catenaccio, J Caccese, N Wakschlag, R Fleysher, N Kim, M Kim, T A Buckley, W F Stewart, R B Lipton, T Kaminski, M L Lipton
The long-term effects of repetitive head impacts due to heading are an area of increasing concern, and exposure must be accurately measured; however, the validity of self-report of cumulative soccer heading is not known. In order to validate HeadCount, a 2-week recall questionnaire, the number of player-reported headers was compared to the number of headers observed by trained raters for a men's and a women's collegiate soccer teams during an entire season of competitive play using Spearman's correlations and intraclass correlation coefficients (ICCs), and calibrated using a generalized estimating equation...
October 2016: Research in Sports Medicine
https://www.readbyqxmd.com/read/27787891/a-brief-dietary-assessment-predicts-executive-dysfunction-in-an-elderly-cohort-results-from-the-einstein-aging-study
#15
Erin E Sundermann, Mindy J Katz, Richard B Lipton, Alice H Lichtenstein, Carol A Derby
OBJECTIVES: To examine the association between diet and executive function, episodic memory and global verbal cognition in the Einstein Aging Study (EAS) cohort and determine whether race modifies this relationship. DESIGN: Cross-sectional. SETTING: Community. PARTICIPANTS: EAS participants without dementia who completed the Rapid Eating and Activity Assessment for Patients (REAP) (N = 492). MEASUREMENTS: The previously validated REAP is based on the 2000 U...
November 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27760312/impaired-mitochondrial-dynamics-and-mitophagy-in-neuronal-models-of-tuberous-sclerosis-complex
#16
Darius Ebrahimi-Fakhari, Afshin Saffari, Lara Wahlster, Alessia Di Nardo, Daria Turner, Tommy L Lewis, Christopher Conrad, Jonathan M Rothberg, Jonathan O Lipton, Stefan Kölker, Georg F Hoffmann, Min-Joon Han, Franck Polleux, Mustafa Sahin
Tuberous sclerosis complex (TSC) is a neurodevelopmental disease caused by TSC1 or TSC2 mutations and subsequent activation of the mTORC1 kinase. Upon mTORC1 activation, anabolic metabolism, which requires mitochondria, is induced, yet at the same time the principal pathway for mitochondrial turnover, autophagy, is compromised. How mTORC1 activation impacts mitochondrial turnover in neurons remains unknown. Here, we demonstrate impaired mitochondrial homeostasis in neuronal in vitro and in vivo models of TSC...
October 18, 2016: Cell Reports
https://www.readbyqxmd.com/read/27746701/regional-versus-general-anaesthesia-for-improved-cognitive-function-after-procedures-other-than-cardiac-surgery-or-neurosurgery-in-adult-and-paediatric-patients
#17
Michael H Andreae, Arthur Atchabahian, Aileen M McCrillis, Jerry Y Chao, Suzuko Suzuki, Shlomo Shinnar, Charles B Hall, Richard B Lipton
This is the protocol for a review and there is no abstract. The objectives are as follows: The objective of this review is to compare the effects of regional versus general anaesthesia on cognitive function after procedures other than cardiac surgery or neurosurgery in adult and in paediatric patients.
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27743818/congenital-single-coronary-artery-a-rare-anatomic-variant
#18
James W Hansen, Alaa Ayyoub, Neil Yager, Sergio Waxman
Isolated congenital single coronary artery (SCA) is rare (incidence 0.024-0.066%). We present a case of a Lipton -1 subtype single coronary artery, incidentally discovered on coronary angiography prior to mitral valve surgery.
September 29, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27733357/spectrum-of-somatic-mutation-dynamics-in-chronic-myeloid-leukemia-following-tyrosine-kinase-inhibitor-therapy
#19
TaeHyung Kim, Marc S Tyndel, Hyeoung Joon Kim, Jae-Sook Ahn, Seung Hyun Choi, Hee Jeong Park, Yeo-Kyeoung Kim, Soo Young Kim, Jeffrey H Lipton, Zhaolei Zhang, Dennis Dong Hwan Kim
Somatic mutations commonly detected in a variety of myeloid neoplasms have not been systematically investigated in chronic myeloid leukemia (CML). We performed targeted deep sequencing on a total of 300 serial samples from 100 CML patients; thirty-seven patients carried mutations. Sixteen of these had evidence of mutations originating from preleukemic clones. Using unsupervised hierarchical clustering, we identified five distinct patterns of mutation dynamics arising following tyrosine kinase inhibitor (TKI) therapy...
October 12, 2016: Blood
https://www.readbyqxmd.com/read/27732597/digitized-spiral-drawing-a-possible-biomarker-for-early-parkinson-s-disease
#20
Marta San Luciano, Cuiling Wang, Roberto A Ortega, Qiping Yu, Sarah Boschung, Jeannie Soto-Valencia, Susan B Bressman, Richard B Lipton, Seth Pullman, Rachel Saunders-Pullman
INTRODUCTION: Pre-clinical markers of Parkinson's Disease (PD) are needed, and to be relevant in pre-clinical disease, they should be quantifiably abnormal in early disease as well. Handwriting is impaired early in PD and can be evaluated using computerized analysis of drawn spirals, capturing kinematic, dynamic, and spatial abnormalities and calculating indices that quantify motor performance and disability. Digitized spiral drawing correlates with motor scores and may be more sensitive in detecting early changes than subjective ratings...
2016: PloS One
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