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Michael H Andreae, Arthur Atchabahian, Aileen M McCrillis, Jerry Y Chao, Suzuko Suzuki, Shlomo Shinnar, Charles B Hall, Richard B Lipton
This is the protocol for a review and there is no abstract. The objectives are as follows: The objective of this review is to compare the effects of regional versus general anaesthesia on cognitive function after procedures other than cardiac surgery or neurosurgery in adult and in paediatric patients.
2016: Cochrane Database of Systematic Reviews
James W Hansen, Alaa Ayyoub, Neil Yager, Sergio Waxman
Isolated congenital single coronary artery (SCA) is rare (incidence 0.024-0.066%). We present a case of a Lipton -1 subtype single coronary artery, incidentally discovered on coronary angiography prior to mitral valve surgery.
September 29, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
TaeHyung Kim, Marc S Tyndel, Hyeoung Joon Kim, Jae-Sook Ahn, Seung Hyun Choi, Hee Jeong Park, Yeo-Kyeoung Kim, Soo Young Kim, Jeffrey H Lipton, Zhaolei Zhang, Dennis Dong Hwan Kim
Somatic mutations commonly detected in a variety of myeloid neoplasms have not been systematically investigated in chronic myeloid leukemia (CML). We performed targeted deep sequencing on a total of 300 serial samples from 100 CML patients; thirty-seven patients carried mutations. Sixteen of these had evidence of mutations originating from preleukemic clones. Using unsupervised hierarchical clustering, we identified five distinct patterns of mutation dynamics arising following tyrosine kinase inhibitor (TKI) therapy...
October 12, 2016: Blood
Marta San Luciano, Cuiling Wang, Roberto A Ortega, Qiping Yu, Sarah Boschung, Jeannie Soto-Valencia, Susan B Bressman, Richard B Lipton, Seth Pullman, Rachel Saunders-Pullman
INTRODUCTION: Pre-clinical markers of Parkinson's Disease (PD) are needed, and to be relevant in pre-clinical disease, they should be quantifiably abnormal in early disease as well. Handwriting is impaired early in PD and can be evaluated using computerized analysis of drawn spirals, capturing kinematic, dynamic, and spatial abnormalities and calculating indices that quantify motor performance and disability. Digitized spiral drawing correlates with motor scores and may be more sensitive in detecting early changes than subjective ratings...
2016: PloS One
Richard B Lipton, Sagar Munjal, Dawn C Buse, Kristina M Fanning, Alix Bennett, Michael L Reed
BACKGROUND: Pain freedom at 2 hours and sustained pain response at 24 hours are important outcomes of acute migraine therapy. Some studies have examined rates and predictors of successful treatment outcomes for single attacks in clinical trials. However, little is known about predictors of typical response to acute treatment over multiple attacks in the population. OBJECTIVES: To identify sociodemographic features, headache characteristics, comorbidities and treatment-related factors that predict acute treatment success or failure at 2 hours and 24 hours post dose in a US population sample of persons with episodic migraine...
October 12, 2016: Headache
Jeffrey M Lipton, Blanche P Alter
No abstract text is available yet for this article.
October 8, 2016: Pediatric Blood & Cancer
Erin E Sundermann, Pauline M Maki, Leah H Rubin, Richard B Lipton, Susan Landau, Anat Biegon
OBJECTIVE: We investigated sex differences in verbal memory across different levels of neural dysfunction, measured by temporal lobe glucose metabolic rates (TLGluMR). METHODS: Three hundred ninety controls and 672 participants with amnestic mild cognitive impairment (aMCI) and 254 with Alzheimer disease (AD) dementia from the Alzheimer's Disease Neuroimaging Initiative completed the Rey Auditory Verbal Learning Test (RAVLT) and [(18)F]-fluorodeoxyglucose-PET. Cross-sectional analyses were conducted using linear regression to examine the sex by TLGluMR interaction on RAVLT performance in the overall sample and within diagnostic groups adjusting for age, education, and APOE ε4 genotype...
October 5, 2016: Neurology
Jing Sun, Jonathan D Todd, J Cameron Thrash, Yanping Qian, Michael C Qian, Ben Temperton, Jiazhen Guo, Emily K Fowler, Joshua T Aldrich, Carrie D Nicora, Mary S Lipton, Richard D Smith, Patrick De Leenheer, Samuel H Payne, Andrew W B Johnston, Cleo L Davie-Martin, Kimberly H Halsey, Stephen J Giovannoni
No abstract text is available yet for this article.
October 3, 2016: Nature Microbiology
Nancy Krieger, George Davey Smith
'Causal inference', in 21st century epidemiology, has notably come to stand for a specific approach, one focused primarily on counterfactual and potential outcome reasoning and using particular representations, such as directed acyclic graphs (DAGs) and Bayesian causal nets. In this essay, we suggest that in epidemiology no one causal approach should drive the questions asked or delimit what counts as useful evidence. Robust causal inference instead comprises a complex narrative, created by scientists appraising, from diverse perspectives, different strands of evidence produced by myriad methods...
September 30, 2016: International Journal of Epidemiology
Sirimon Reutrakul, Ammarin Thakkinstian, Thunyarat Anothaisintawee, Sasipas Chontong, Anne-Laure Borel, Michelle M Perfect, Carolina Castro Porto Silva Janovsky, Romain Kessler, Bernd Schultes, Igor Alexander Harsch, Marieke van Dijk, Didier Bouhassira, Bartlomiej Matejko, Rebecca B Lipton, Parawee Suwannalai, Naricha Chirakalwasan, Anne-Katrin Schober, Kristen L Knutson
OBJECTIVES: The association between inadequate sleep and type 2 diabetes has garnered much attention, but little is known about sleep and type 1 diabetes (T1D). Our objectives were to conduct a systematic review and meta-analysis comparing sleep in persons with and without T1D, and to explore relationships between sleep and glycemic control in T1D. METHODS: Studies were identified from Medline and Scopus. Studies reporting measures of sleep in T1D patients and controls, and/or associations between sleep and glycemic control, were selected...
July 2016: Sleep Medicine
Arjun Datt Law, Dennis Dong Hwan Kim, Jeffrey Howard Lipton
No abstract text is available yet for this article.
September 29, 2016: Leukemia & Lymphoma
Howard L Lipton, Ken Tyler
No abstract text is available yet for this article.
October 2016: Journal of Neurovirology
Herman Buschke, Wenzhu B Mowrey, Wendy S Ramratan, Molly E Zimmerman, David A Loewenstein, Mindy J Katz, Richard B Lipton
OBJECTIVE: We aimed to assess reliability and cross-sectional discriminative validity of the Memory Binding Test (MBT) to distinguish persons with amnestic cognitive impairment (aMCI) and dementia from cognitively normal elderly controls. METHOD: The MBT was administered to 20 participants with dementia, 31 with aMCI and 246 controls, who received the first administration of the MBT from May 2003 to December 2007, as a substudy of the community-based Einstein Aging Study (age range: 70+)...
September 27, 2016: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
Lironne Wein, Catherine Rowe, Benjamin Brady, Despina Handolias, Lara Lipton, David Pook, Robert Stanley, Ian Haines
BACKGROUND: In recent years there has been a significant increase in the number of cancer treatments that have become available. However, it has remained difficult to choose the most appropriate time to cease active therapy in individual patients. AIM: To determine the proportion of patients being treated with palliative intent who received systemic anticancer treatment in the last 30 days of life. METHODS: This is a retrospective cohort study conducted within the Melbourne Oncology Group at Cabrini Hospital...
September 23, 2016: Internal Medicine Journal
Andrea R Zammit, Ali Ezzati, Molly E Zimmerman, Richard B Lipton, Michael L Lipton, Mindy J Katz
INTRODUCTION: Selective hippocampal (HC) subfield atrophy has been reported in older adults with mild cognitive impairment and Alzheimer's disease. The goal of this study was to investigate the associations between the volume of hippocampal subfields and visual and verbal episodic memory in cognitively normal older adults. METHODS: This study was conducted on a subset of 133 participants from the Einstein Aging Study (EAS), a community-based study of non-demented older adults systematically recruited from the Bronx, N...
September 16, 2016: Behavioural Brain Research
Huahua Jiang, Yong Deng, Yixin Zhang, Jieli Jin, Xueying Kong, Qiuwen Zhu, Kuiyun Wang, Jiying Zhou
BACKGROUND: Chronic headache (CrH) occurs commonly in the population, and chronic migraine (CM) accounts for much of the CrH. Diagnostic criteria for CM remain controversial, and this could lead to undertreatment of CM. The purpose of this study was to analyze the clinical profiles of CM and to field test the International Classification of Headache Disorders-3β criteria (ICHD-3β) and Expert Opinion criteria (EO) for CM application. METHODS: We retrospectively reviewed the medical records of CrH patients in our headache clinic during the period...
December 2016: Journal of Headache and Pain
R Barzilay, F Ventorp, H Segal-Gavish, I Aharony, A Bieber, S Dar, M Vescan, R Globus, A Weizman, D Naor, J Lipton, S Janelidze, L Brundin, D Offen
CD44 is a cell surface adhesion molecule and its principal ligand is hyaluronic acid (HA), a key component of the brain's extracellular matrix. CD44 levels are decreased in the cerebrospinal fluid (CSF) of depressed individuals, and the CD44 gene has been identified in genome wide association study as a possible risk gene in suicidal behavior. In order to define the pathobiological mechanisms by which CD44 may affect behavior, we investigated the role of CD44 using male CD44 knockout (CD44KO) and wild-type mice that underwent chronic mild stress (CMS)...
September 13, 2016: Journal of Molecular Neuroscience: MN
J Selvin Pitchaikani, A P Lipton
Nutrients and phytoplankton dynamics in the traditional fishing grounds off Tiruchendur coast, Gulf of Mannar, India revealed a clear seasonal trend influenced by prevailing monsoon system in east coast of India. A total of 73 species of phytoplankton were identified from the fishing grounds, revealed higher abundance in summer months compared to other seasons. Among the three stations, maximum phytoplankton abundance was recorded in station 2 followed by stations 1 and 3. The phytoplankton abundance ranged from 2...
2016: SpringerPlus
Hassan Sibai, Umberto Falcone, Uday Deotare, Fotios V Michelis, Jieun Uhm, Vikas Gupta, John Kuruvilla, Jeffrey H Lipton, Matthew D Seftel, Hans A Messner, Dennis Dong Hwan Kim
Reduced-intensity conditioning (RIC) has been shown to have similar overall survival (OS) but higher relapse rates compared with myeloablative (MAC) regimens in patients with myeloid malignancies undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Using propensity score matching (PSM) analysis, well-balanced pairs of different variables can be compared effectively. We retrospectively compared allo-HSCT recipients with acute myelogenous leukemia or myelodysplasia receiving an RIC regimen (FBT200; fludarabine 30 mg/m(2)/day for 4 days, busulfan 3...
September 3, 2016: Biology of Blood and Marrow Transplantation
Marc Poch Martell, Hassan Sibai, Uday Deotare, Jeffrey H Lipton
INTRODUCTION: Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder that has become the neoplastic poster child for understanding the disease biology of a malignant disease and targeting effective therapy. The targeted therapy of BCR-ABL inhibition by tyrosine kinase inhibitors (TKI) has provided the epitome for "Ehlrich's magic bullet" postulated decades ago. AREAS COVERED: Due to the therapy with these drugs, the survival of newly diagnosed patients with this disease now approaches that of age matched controls...
October 2016: Expert Review of Hematology
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