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https://www.readbyqxmd.com/read/28169230/adjuvant-treatment-for-stage-i-seminoma-why-radiotherapy-is-better-than-carboplatin
#1
REVIEW
Prahlad H Yathiraj, Krishna Sharan, Donald J Fernandes, M S Vidyasagar
Adjuvant treatment options for Stage I seminoma include active surveillance, chemotherapy, and radiotherapy. Active surveillance may not be ideal for the average Indian patient. Of the two accepted adjuvant therapy options, namely single-dose carboplatin chemotherapy and radiotherapy to the retroperitoneal nodes, though it intuitively appears more appealing, a deeper review reveals the potential drawbacks of chemotherapy. This article highlights the misconceptions regarding carboplatin and provides reasons for an argument why radiotherapy is better when a patient with Stage I seminoma chooses to undergo adjuvant treatment...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28163811/retroperitoneal-hematoma-following-radical-orchiectomy-two-cases
#2
Rachel Glicksman, Robert J Hamilton, Peter Chung
Treatment of testicular cancer is dependent on the stage of disease at presentation. Stage 1 testicular cancer is treated with radical orchiectomy, followed by active surveillance, radiotherapy, or chemotherapy. Occasionally, unusual and unexpected postoperative changes can be seen on computed tomography (CT), and may raise concern for metastatic disease. Here, we present two cases of testicular cancer patients who developed retroperitoneal hematomas post-radical orchiectomy, one as a classical clinical presentation, and the other as an atypical radiological entity only...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28161539/a-novel-role-of-kif3b-in-the-seminoma-cell-cycle
#3
Hao-Qing Shen, Yu-Xi Xiao, Zhen-Yu She, Fu-Qing Tan, Wan-Xi Yang
KIF3b is a protein of the kinesin-2 family which plays an important role in intraflagellar transport. Testis cancer is a common cancer among young men. Its diagnostic rate is increasing and over half of the cases are seminomas. Many aspects of the mechanism and gene expression background of this cancer remain unclear. Using western-blotting and semi-quantitative PCR we found high protein levels of KIF3b enrichment in seminoma tissue despite the mRNA levels remaining equivalent to that of normal testicular tissues...
February 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28160884/testicular-seminoma
#4
Sounak Gupta, Lori A Erickson
No abstract text is available yet for this article.
February 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28153774/patterns-of-care-and-survival-outcomes-for-adolescent-and-young-adult-patients-with-testicular-seminoma-in-the-united-states-a-national-cancer-database-analysis
#5
William Stokes, Arya Amini, Paul D Maroni, Elizabeth R Kessler, Claire Stokes, Carrye R Cost, Brian S Greffe, Timothy P Garrington, Arthur K Liu, Nicholas G Cost
INTRODUCTION: Testicular germ cell tumors (GCTs) are the most common solid tumor among adolescent and young adult (AYA) males. AYA patients with GCTs most typically have non-seminoma compared with seminoma, and accordingly there are fewer data reported on the AYA experience with testicular seminoma. OBJECTIVE: To evaluate national trends in postoperative treatment and overall survival (OS) outcomes in testicular seminoma by age group, specifically comparing AYAs with older adults...
January 17, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28147469/thymoma-and-synchronous-primary-mediastinal-seminomas-with-florid-follicular-lymphoid-hyperplasia-in-the-anterior-mediastinum-a-case-report-and-review-of-the-literature
#6
Hyang-Im Lee, In-Seok Jang, Kyung Nyeo Jeon, Gyung Hyuck Ko, Jong Sil Lee, Dong Chul Kim, Dae Hyun Song, Jeong-Hee Lee
Thymoma is the most common neoplasm of the anterior mediastinum and has malignant potential. Germ cell tumors (GCTs) found in the anterior mediastinum are usually benign, and malignant GCTs, such as seminomas, are rare. Histologically, mediastinal seminoma is indistinguishable from testicular seminoma except for site-associated morphological features such as lymphoid follicular hyperplasia. Therefore, excluding metastasis is very important. Recently, we treated a young adult patient with multiple thymic masses that occurred simultaneously...
February 2, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28124497/maternal-preeclampsia-and-odds-of-childhood-cancers-in-offspring-a-california-statewide-case-control-study
#7
Xiaoqing Xu, Beate Ritz, Myles Cockburn, Christina Lombardi, Julia E Heck
BACKGROUND: Preeclampsia is a major cause of adverse effects on fetal health. We examined associations between fetal exposure to preeclampsia and subsequent odds of childhood cancers. METHODS: We obtained childhood cancer cases (n = 13 669) diagnosed at 5 years old or younger between 1988 and 2012 from the California Cancer Registry and linked them to birth certificates. Controls (n = 271 383) were randomly selected from all California births and frequency matched to cases by birth year...
January 26, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28120026/-blast-like-tumor-tissue-in-cervical-lymph-node-with-expression-of-placental-alkaline-phosphatase
#8
C Fellbaum, S Kircher, U Oehler, R Blessing, A Rosenwald
We report a case of ALK1-positive anaplastic large cell lymphoma with expression of placental alkaline phosphatase (PLAP) in many tumor cells. Initially, due to the positivity of tumor cells for CD30 and PLAP, lymph node metastasis of a germ cell neoplasm was discussed. Anaplastic large cell lymphomas of T‑cell lineage form a group of rare non-Hodgkin lymphomas with heterogeneous morphological and immunohistochemical appearance. They may imitate other neoplasms, such as large cell B‑cell lymphomas, metastasis of a carcinoma, melanoma, embryonal carcinoma or seminoma, rhabdomyosarcoma and inflammatory myofibroblastic tumor...
January 24, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28110489/video-assisted-laser-resection-of-lung-metastases-feasibility-of-a-new-surgical-technique
#9
Christian Meyer, Detlef Bartsch, Nikolas Mirow, Andreas Kirschbaum
Background Our pilot study describes our initial experience to do a laser resection of lung metastases under video-assisted thoracoscopic control via a minithoracotomy. With this approach, if needed, mediastinal lymphadenectomy is also possible. Methods In this study, 15 patients (11 men and 4 women, mean age: 60 years) with resectable lung metastases of different solid primary tumors (colorectal cancer in seven patients, melanoma in three patients, renal cell carcinoma in two patients, and one each with oropharyngeal cancer, breast cancer, and seminoma) were included...
January 22, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28101903/development-and-characterization-of-anti-glycopeptide-monoclonal-antibodies-against-human-podoplanin-using-glycan-deficient-cell-lines-generated-by-crispr-cas9-and-talen
#10
Mika K Kaneko, Takuro Nakamura, Ryusuke Honma, Satoshi Ogasawara, Yuki Fujii, Shinji Abe, Michiaki Takagi, Hiroyuki Harada, Hiroyoshi Suzuki, Yasuhiko Nishioka, Yukinari Kato
Human podoplanin (hPDPN), which binds to C-type lectin-like receptor-2 (CLEC-2), is involved in platelet aggregation and cancer metastasis. The expression of hPDPN in cancer cells or cancer-associated fibroblasts indicates poor prognosis. Human lymphatic endothelial cells, lung-type I alveolar cells, and renal glomerular epithelial cells express hPDPN. Although numerous monoclonal antibodies (mAbs) against hPDPN are available, they recognize peptide epitopes of hPDPN. Here, we generated a novel anti-hPDPN mAb, LpMab-21...
January 19, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28073875/unexpected-complication-after-radical-inguinal-orchidectomy-trans-sphincteric-anoscrotal-fistula
#11
Amit Patel, Chris Gillespie, Anthony J Kiosoglous
Anoscrotal fistula is an extremely rare condition involving an epithelialised tract between the anal canal and scrotal wall. It is more commonly seen as a congenital phenomenon in the paediatric population, and has not previously been described in the literature in adults. We present the case of a man aged 52 years who developed a complex anoscrotal fistula after a radical inguinal orchidectomy for an intratesticular seminoma. A postsurgical wound-site infection developed into a chronically discharging wound refractory to antibiotic treatment prompting further investigation...
January 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28073203/testicular-sparing-surgery-in-small-testis-masses-a-multinstitutional-experience
#12
Andrea B Galosi, Paola Fulvi, Andrea Fabiani, Lucilla Servi, Alessandra Filosa, Luca Leone, Angelo Marronaro, Enrico Caraceni, Rodolfo Montironi
INTRODUCTION: The incidence of benign testicular tumors is increasing in particular in small lesion incidentally found at scrotal ultrasonography. Primary aim of this study was to perform radical surgery in malignant tumor. Secondary aim was to verify the efficacy of the diagnostic-therapeutic pathway recently adopted in management of small masses with testis sparing surgery in benign lesions. MATERIALS AND METHODS: In this multicenter study, we reviewed all patients with single testis lesion less than 15 mm at ultrasound as main diameter...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28058002/the-diagnostic-yield-of-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-recurrent-testicular-seminoma
#13
Athanasios Bantis, Petros Sountoulides, Linda Metaxa, Pavlos Pavlidis, Eleni Aggelonidou, Halil Arif, Athanasios Zisimopoulos
The use of positron emission tomography-computed tomography (PET-CT) scan imaging is undoubtedly a significant evolution in oncological urology, although at present of limited use in every day urology practice. The aim of this study is to highlight the indication and diagnostic accuracy of fluorine-18 fluorodeoxyglucose PET/CT in the staging of a patient with metachronous bilateral testicular seminoma, elevated tumor markers, and equivocal conventional imaging findings.
October 2016: Urology Annals
https://www.readbyqxmd.com/read/28054535/combined-prednisolone-and-pirfenidone-in-bleomycin-induced-lung-disease
#14
Preyas J Vaidya, H S Sandeepa, Tejinder Singh, S K Susheel Kumar, Rajat Bhargava, Gopal Ramakrishnan, Prashant N Chhajed
Bleomycin is a cytostatic drug commonly employed in the treatment of Hodgkin's disease, seminomas, and choriocarcinoma. Bleomycin may induce a chronic pulmonary inflammation that may progress to fibrosis. So far, only corticosteroids have been used in the treatment of bleomycin-induced lung disease with variable results. Pirfenidone is an antifibrotic drug that has been approved for the treatment of idiopathic pulmonary fibrosis. We report two cases of bleomycin-induced lung disease treated successfully with pirfenidone and oral corticosteroids...
July 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28054283/mediastinal-seminoma-associated-with-multilocular-thymic-cyst
#15
Masato Inui, Jun-Ichi Nitadori, Shogo Tajima, Takahusa Yoshioka, Noriko Hiyama, Takeyuki Watadani, Aya Shinozaki-Ushiku, Kazuhiro Nagayama, Masaki Anraku, Masaaki Sato, Masashi Fukayama, Jun Nakajima
An asymptomatic 26-year-old man received an annual medical check-up, and chest X-ray showed a protrusion of the aortopulmonary window. Chest computed tomography (CT) revealed an anterior mediastinal tumor and cysts with thin wall and septum enhancement. The preoperative diagnosis was cystic thymoma or malignant lymphoma. We performed total resection of the tumor through a median sternotomy. The pathological findings revealed seminoma, positive for c-kit stain, and multilocular thymic cysts. Cysts were lined by normal squamous epithelium and no seminoma cells were located on their surface...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28039344/complete-androgen-insensitivity-syndrome-with-concomitant-seminoma-and-sertoli-cell-adenoma-an-unusual-combination
#16
Balamurugan Thirunavukkarasu, Asit Ranjan Mridha, Neena Malhotra, Sheragaru Hanumanthappa Chandrashekhara
Androgen insensitivity syndrome is a rare disorder of sex development and its clinical manifestations vary from subtle male infertility to an overt complete androgen insensitivity syndrome (CAIS) with a female phenotype. CAIS is often diagnosed at puberty or in adolescence during investigation for primary amenorrhoea. Undiagnosed patients have an increased risk of development of malignancy in the harboured testes. Inguinal hernia is the commonest mode of presentation of CAIS in childhood and various screening methods are available during the initial herniorrhaphy procedure...
December 30, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/28027619/is-there-any-difference-between-seminomas-and-nonseminomatous-germ-cell-tumors-on-shear-wave-elastography-a-preliminary-study
#17
Atilla Suleyman Dikici, Mehmet Emin Er, Deniz Alis, Cesur Samanci, Fethi Emre Ustabasioglu, Cetin Demirdag, Haydar Durak, Fatih Kantarci, Ismail Mihmanli
OBJECTIVES: The purpose of this study was to evaluate the ability of shear wave elastography (SWE) to differentiate seminomas from nonseminomatous germ cell tumors. METHODS: Approval for this retrospective study was obtained from the local Ethics Committee of Istanbul University Cerrahpasa Medical School. Fifteen patients with malignant testicular lesions were examined by grayscale sonography, color or power Doppler sonography, and SWE between February 2011 and October 2015...
December 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28026145/the-bromodomain-inhibitor-jq1-triggers-growth-arrest-and-apoptosis-in-testicular-germ-cell-tumours-in-vitro-and-in-vivo
#18
Sina Jostes, Daniel Nettersheim, Martin Fellermeyer, Simon Schneider, François Hafezi, Friedemann Honecker, Valerie Schumacher, Matthias Geyer, Glen Kristiansen, Hubert Schorle
Type II testicular germ cell cancers (TGCT) are the most frequently diagnosed tumours in young men (20-40 years) and are classified as seminoma or non-seminoma. TGCTs are commonly treated by orchiectomy and chemo- or radiotherapy. However, a subset of metastatic non-seminomas (embryonal carcinomas) displays only incomplete remission or relapse and requires novel treatment options. Recent studies have shown effective application of the small-molecule inhibitor JQ1 in tumour therapy, which interferes with the function of 'bromodomain and extraterminal (BET)' proteins...
December 27, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28004146/residual-tumor-resection-rtr
#19
A Lusch, P Albers
Residual tumor resection in patients with advanced testicular tumor plays a vital role in the multimodal treatment. Treatment indications for residual tumor resection have changed over the last two decades. While patients with advanced seminoma after chemotherapy or radiotherapy rarely need surgery, it is mandatory for most non-seminomatous tumor patients to undergo post-chemotherapy tumor resection. Due to adjunctive surgical procedures, the operation is surgically demanding and should be performed only in specialized high-volume referral centers...
December 21, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/28003760/comparison-of-the-clinical-features-and-hematopoietic-stem-cell-transplantation-outcomes-of-mediastinal-malignant-germ-cell-tumors-with-nonmediastinal-extragonadal-placements
#20
Nesrin Ocal, Birol Yildiz, Nuri Karadurmus, Deniz Dogan, Sukru Ozaydin, Ramazan Ocal, Mustafa Ozturk, Fikret Arpaci, Hayati Bilgic
OBJECTIVE: Even though the primary mediastinal extragonadal germ cell tumors (EGCTs) are rare, they are noteworthy in the differential diagnosis of mediastinal masses. In this study, we aimed to identify the clinical features of mediastinal malignant GCTs and compare the results of hematopoietic stem cell transplantation between mediastinal and nonmediastinal malignant EGCTs. METHOD: Data of the patients with EGCT who were treated and underwent hematopoietic stem cell transplantation at our hospital between 1988 and 2015 were retrieved retrospectively...
2016: OncoTargets and Therapy
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