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https://www.readbyqxmd.com/read/29345008/current-knowledge-of-risk-factors-for-testicular-germ-cell-tumors
#1
REVIEW
Tomoya Fukawa, Hiro-Omi Kanayama
The development of the human gonads is tightly regulated by the correct sequential expression of many genes and hormonal activity. Disturbance of this regulation does not only prevent proper development of the gonads, but it also contributes to the development of testicular germ cell tumors. Recent genetic studies, especially genome-wide association studies, have made great progress in understanding genetic susceptibility. Although there is strong evidence of inherited risks, many environmental factors also contribute to the development of testicular germ cell tumors...
January 17, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29336917/changing-practice-evaluation-stage-1-seminoma-outcomes-with-adjuvant-treatment-versus-surveillance-risk-factors-for-recurrence-and-optimizing-follow-up-protocols-experience-from-a-supraregional-center
#2
Helen E J Tyrrell, David N Church, Johnson Joseph, Zoe C Traill, Mark E Sullivan, Mark H Tuthill, Clare L Verrill, Elias P Pintus, Nicola L Dallas, Paul B Rogers, Jacqueline Redgwell, Andrew S Protheroe
BACKGROUND: Stage 1 seminoma is frequently cured by radical orchiectomy; however, the management strategies after this diagnosis vary in terms of the use of adjuvant treatment and the nature of the follow-up protocols. We analyzed stage 1 seminomas treated in the Thames Valley Cancer Network for outcomes to determine whether any factors are predictive of recurrence. We also studied relapses to determine the optimal follow-up schedule and protocol. MATERIALS AND METHODS: Data were obtained from centers within the Thames Valley Cancer Network for a 12-year period from 2004 to 2016...
December 11, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29336660/current-practice-patterns-surrounding-fertility-concerns-in-stage-i-seminoma-patients-survey-of-united-states-radiation-oncologists
#3
Carl M Post, Aditya Jain, Catherine Degnin, Yiyi Chen, Mike Craycraft, Arthur Y Hung, Jerry J Jaboin, Charles R Thomas, Timur Mitin
PURPOSE: Patients with testicular seminoma may face fertility issues because of their underlying disease as well as treatments they undergo. The current patterns of practice among U.S. radiation oncologists aimed at assessing and preserving fertility in patients with Stage I seminoma are unknown. METHODS: We surveyed practicing U.S. radiation oncologists via an Institutional Review Board-approved online questionnaire. Respondents' characteristics and perceived patient infertility rates were analyzed for association with treatment recommendations...
January 16, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29336183/postradiation-synovial-sarcoma-of-the-common-bile-duct-a-previously-unreported-anatomic-site
#4
Roberto Herrera-Goepfert
Synovial sarcoma is a ubiquitous neoplasm predominantly affecting soft tissues of young adults of any gender; few cases have been described in the digestive system, mostly in the stomach. The (X;18)(p11.2; q11.2) translocation yields unique SS18-SSX fusion genes. Synovial sarcoma has been related to radiotherapy, but no synovial sarcoma has been associated with the digestive system. This article describes the case of a synovial sarcoma arising along the extrahepatic biliary tree, 10 years after the application of an abdominal radiotherapy schedule due to a retroperitoneal metastatic seminoma in a male who developed progressive obstructive jaundice...
January 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29334543/seminoma-metastatic-to-the-orbit
#5
Jonathan J Dutton, Alan D Proia
PURPOSE: Seminomas are solid tumors in young men, but which rarely metastasize to the orbit. The authors review the known literature on seminoma metastatic to the orbit, and describe an additional case in a 33-year-old man. METHODS: A literature search was performed on the MEDLINE database using keywords "seminoma," "testicular germ-cell tumors," "testicular cancer," "testicular neoplasm," "orbital metastasis," and "germ-cell neoplasms." RESULTS: Malignant neoplasms of the testis account for only 1% of cancers in men...
January 12, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29324788/esrp1-is-a-marker-of-mouse-fetal-germ-cells-and-differentially-expressed-during-spermatogenesis
#6
Shaghayegh Saeidi, Farnaz Shapouri, Robb U de Iongh, Franca Casagranda, Jessie M Sutherland, Patrick S Western, Eileen A McLaughlin, Mary Familari, Gary R Hime
ESRP1 regulates alternative splicing, producing multiple transcripts from its target genes in epithelial tissues. It is upregulated during mesenchymal to epithelial transition associated with reprogramming of fibroblasts to iPS cells and has been linked to pluripotency. Mouse fetal germ cells are the founders of the adult gonadal lineages and we found that Esrp1 mRNA was expressed in both male and female germ cells but not in gonadal somatic cells at various stages of gonadal development (E12.5-E15.5). In the postnatal testis, Esrp1 mRNA was highly expressed in isolated cell preparations enriched for spermatogonia but expressed at lower levels in those enriched for pachytene spermatocytes and round spermatids...
2018: PloS One
https://www.readbyqxmd.com/read/29324254/prdm14-is-expressed-in-germ-cell-tumors-with-constitutive-overexpression-altering-human-germline-differentiation-and-proliferation
#7
Joanna J Gell, Jasmine Zhao, Di Chen, Timothy J Hunt, Amander T Clark
Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate. One recently identified susceptibility loci for human GCT is PR (PRDI-BF1 and RIZ) domain proteins 14 (PRDM14). PRDM14 is expressed in early primate PGCs and is repressed as PGCs differentiate. To examine PRDM14 in human GCTs we profiled human GCT cell lines and patient samples and discovered that PRDM14 is expressed in embryonal carcinoma cell lines, embryonal carcinomas, seminomas, intracranial germinomas and yolk sac tumors, but is not expressed in teratomas...
January 4, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29309304/the-significance-of-spermatic-cord-involvement-by-testicular-germ-cell-tumors-should-we-be-staging-discontinuous-invasion-from-involved-lymphovascular-spaces-differently-from-direct-extension
#8
Joseph M Sanfrancesco, Karen E Trevino, Huiping Xu, Thomas M Ulbright, Muhammad T Idrees
The recent 8th edition of the American Joint Committee on Cancer (AJCC) staging manual had multiple changes concerning how pathologists should stage germ cell tumors (GCTs) of the testis. A significant one concerns the impact of different types of spermatic cord involvement, specifically direct tumor extension versus discontinuous involvement by invasion through lymphovascular spaces. We compared clinicopathologic findings and outcome data between 2 cohorts with these findings to evaluate the validity of the change in the AJCC 8th edition manual...
January 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29306641/testicular-seminoma-scattered-radiation-dose-to-the-contralateral-testis-in-the-modern-era
#9
Hester Lieng, Peter Chung, Tony Lam, Padraig Warde, Tim Craig
PURPOSE: Limited data exist on testicular dose measurements using modern radiation treatment techniques and volumes for testicular seminoma. The aim of this study was to report the testicular dose using in vivo measurements in men with testicular seminoma receiving abdominopelvic radiation therapy (APRT) and a modified dog-leg field with and without gonadal shielding. METHODS AND MATERIALS: Men with histologically confirmed testicular seminoma, either newly diagnosed stage II disease or isolated retroperitoneal relapse on surveillance for stage I disease, treated with APRT had testicular dose measurements recorded using MOSFET dosimeters...
January 3, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29301509/assessment-of-pirna-biogenesis-and-function-in-testicular-germ-cell-tumors-and-their-precursor-germ-cell-neoplasia-in-situ
#10
Ildar V Gainetdinov, Yulia V Skvortsova, Sofia A Kondratieva, Alexey Klimov, Alexey A Tryakin, Tatyana L Azhikina
BACKGROUND: Aberrant overexpression of PIWI/piRNA pathway proteins is shown for many types of tumors. Interestingly, these proteins are downregulated in testicular germ cell tumors (TGCTs) compared to normal testis tissues. Here, we used germline and TGCT markers to assess the piRNA biogenesis and function in TGCTs and their precursor germ cell neoplasia in situ (GCNIS). METHODS: We used small RNA deep sequencing, qRT-PCR, and mining public RNAseq/small RNA-seq datasets to examine PIWI/piRNA gene expression and piRNA biogenesis at four stages of TGCT development: (i) germ cells in healthy testis tissues, (ii) germ cells in testis tissues adjacent to TGCTs, (iii) GCNIS cells and (iv) TGCT cells...
January 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29280854/spermatocytic-seminoma-a-report-of-85-cases-emphasizing-its-morphologic-spectrum-including-some-aspects-not-widely-known
#11
Rong Hu, Thomas M Ulbright, Robert H Young
Spermatocytic seminoma (or, alternatively, spermatocytic tumor) of the testis is rare and errors in pathologic diagnosis are still made. As it has a good prognosis, except when it, rarely, undergoes sarcomatous transformation, accurate diagnosis and differentiating it from usual seminoma and other malignant neoplasms such as lymphoma are crucial. To potentially contribute information of diagnostic aid we reviewed the largest series of cases reported to date to characterize in detail their histologic spectrum...
December 26, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29280438/salvage-treatment-options-for-recurrent-seminoma
#12
EDITORIAL
Michael Pinkawa
No abstract text is available yet for this article.
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29279166/characterization-of-testicular-germ-cell-tumors-whole-lesion-histogram-analysis-of-the-apparent-diffusion-coefficient-at-3t
#13
Xiangde Min, Zhaoyan Feng, Liang Wang, Jie Cai, Xu Yan, Basen Li, Zan Ke, Peipei Zhang, Huijuan You
PURPOSE: To assess the values of parameters derived from whole-lesion histograms of the apparent diffusion coefficient (ADC) at 3T for the characterization of testicular germ cell tumors (TGCTs). MATERIALS AND METHODS: A total of 24 men with TGCTs underwent 3T diffusion-weighted imaging. Fourteen tumors were pathologically confirmed as seminomas, and ten tumors were pathologically confirmed as nonseminomas. Whole-lesion histogram analysis of the ADC values was performed...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29279100/long-term-toxicity-of-the-treatment-for-germ-cell-cancer-a-review
#14
REVIEW
P Maroto, G Anguera, C Martin
Testicular germ-cell cancer (GCC) is a curable disease. Stage I patients are mostly cured by surgery alone. For those with good prognosis advanced disease, radiotherapy in some patients with stage II Seminoma and chemotherapy for all other patients, are responsible for 95% of long-term survivors. Unfortunately, despite this high level of curability, overall survival has been reported lower for those patients receiving either radiotherapy or chemotherapy versus patients treated by surgery alone. Long-term survivors face a higher incidence of second neoplasms, and a higher risk of cardiovascular disease and metabolic syndrome than expected...
January 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29240582/the-morphologic-spectrum-of-sertoliform-cystadenoma-of-the-rete-testis-a-series-of-15-cases
#15
Swetha Paluru, Thomas M Ulbright, Mahul Amin, Rodolfo Montironi, Jonathan I Epstein
Sertoliform cystadenoma of the rete testis (SCRT) is rare with only 9 cases reported to date in the literature, none with follow-up. Four large genitourinary pathology consult services were searched. We identified 15 cases of SCRT. Men were 21 to 84 years old (mean, 46 y) and had testicular discomfort or mass. Other findings were seminoma (n=1), spermatocele (n=2), hydrocele (n=1), varicocele (n=1), and scrotal hematoma (n=1). Eight had preoperative serum tumor markers, which were normal. Tumors ranged from 0...
December 7, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29218213/two-cases-of-somatic-type-malignancy-as-a-very-late-relapse-of-testicular-cancer-successfully-managed-by-surgical-resection
#16
Satoshi Washino, Tsuzumi Konishi, Kimitoshi Saito, Masashi Ohshima, Yuhki Nakamura, Tomoaki Miyagawa
A late-relapse germ cell tumor might contain malignant non-germ cell tumors, known as 'somatic-type malignancy (SM)'. The development of a secondary SM is rare, and this phenomenon remains poorly understood. Case 1 developed lung metastasis 13 years after chemotherapy followed by retroperitoneal lymph node dissection for stage IIA non-seminoma. The tumor increased in size after chemotherapy. The patient underwent a pneumonectomy. Pathology revealed an adenocarcinoma with immature teratoma. The patient has experienced no relapse for 9 years...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29216530/brain-angiometastasis-from-a-non-seminomatous-germ-cell-tumor-a-case-report
#17
Alejandro Monroy-Sosa, Gervith Reyes-Soto, Bernardo Cacho-Díaz, Martín Granados-García, Allan Hernández Estrada, Ana María Cano-Valdez, Ángel Herrera-Gómez
INTRODUCTION: Brain metastasis from non-seminomatous germ cell tumors (NSGCT) is rare. Herein, we describe the second reported case of brain metastasis from a NSGCT with high-flow arteriovenous (AV) shunts, and propose a novel surgical treatment plan. CLINICAL CASE: The patient was a 34-year-old male who presented with hemiparesis and hemianesthesia. Magnetic resonance angiography revealed three vascular lesions with afferent vessels and efferent vessels. Angiography displayed two high-flow AV shunts...
December 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29201487/primary-malignancy-in-a-supernumerary-testicle-presenting-as-a-large-pelvic-mass
#18
Justin Noroozian, Daniel Farishta, Daniel Ballow, Joseph Sonstein, Eduardo Orihuela, Eduardo Eyzaguirre
Supernumerary testis, also known as polyorchidism, is a condition characterized by the presence of more than two testes. Another condition of the testes is seminoma, a common cause of testicular germ cell tumor. A 35-year-old male was transferred to our hospital with a diagnosis of abdominal mass causing abdominal pain. On physical exam, he had a palpable undescended left testicle in the left inguinal canal, which was determined to be seminoma. The mass was surgically removed, and the patient underwent chemotherapy...
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/29199728/testicular-seminoma-are-clinical-features-and-treatment-outcomes-any-different-in-india
#19
M Anjanappa, A Kumar, S Mathews, J Joseph, K M Jagathnathkrishna, F V James
AIM: This study aims to identify clinical features, treatment outcomes, and prognostic factors for relapse and survival in patients with testicular seminoma. MATERIALS AND METHODS: Retrospective analysis of all patients with pure seminoma treated at our center during over a decade (January 2005-December 2014) was carried out. Patient demographics, tumor characteristics, and treatment details and pattern of recurrence were recorded in a structured format, and disease-free survival and overall survival were calculated...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29197138/testicular-orphan-receptor-4-promotes-tumor-progression-and-implies-poor-survival-through-akt3-regulation-in-seminoma
#20
Yuanlei Chen, Jieyang Lu, Liqun Xia, Dingwei Xue, Xiaoming Yu, Danyang Shen, Liwei Xu, Gonghui Li
Seminoma is recognized as the most common testicular germ cell tumor which mainly occurs in the 15-35-year-old young men worldwide. Early studies have indicated that testicular nuclear receptor 4 (TR4) firstly cloned from testis is involved in the invasion and metastasis of several human tumors, however, little attention is paid to the function of TR4 in Seminoma. Our Immunohistochemical (IHC) staining results showed that patients who underwent advanced stage tended to higher expression of TR4. Importantly, there was a significant association between elevated TR4 expression and reduced Overall Survival in seminoma patients...
December 2, 2017: Cancer Science
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