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Matthäus Majewski, Tim Nestler, Sebastian Kägler, Ines Richardsen, Christian G Ruf, Cord Matthies, Arnulf Willms, Hans-Ulrich Schmelz, Walter Wagner, Robert Schwab, Michael Abend
Tumor cells shed exosomes, which are released to the blood. Detecting tumor-derived exosomes containing RNA in plasma (liquid biopsy) is currently being investigated for early identification of occult metastases or relapses. Isolation of exosomes is laborious, resulting in low RNA yields. As a more robust (but less sensitive) alternative, the authors examined whether whole blood can be used as well. Tumor samples from nonmetastasized seminoma (n = 5) and colon cancer patients (n = 6) were taken during surgery...
July 2018: Health Physics
Lucia Nappi, Margaret Ottaviano, Pasquale Rescigno, Ladan Fazli, Martin E Gleave, Vincenzo Damiano, Sabino De Placido, Giovannella Palmieri
Background: Cisplatin-based chemotherapy significantly improved the survival of patients with germ cell testicular cancer. However, long term side effects of chemotherapy have non-negligible impact on the quality of life of these young patients, who have a long life expectancy after being successfully treated. Materials and Methods: 25-OH vitamin D, testosterone, FSH and LH of patients with testicular cancer were retrospectively evaluated and for each patient clinical information were collected...
April 20, 2018: Oncotarget
Gunhild von Amsberg, Robert Hamilton, Alexandros Papachristofilou
No abstract text is available yet for this article.
May 16, 2018: Oncology Research and Treatment
Anne-Laure Rougemont, Jean-Christophe Tille
Identification of the yolk sac tumor (YST) component in germ cell tumors (GCT) may prove challenging, and highly sensitive and specific immunohistochemical markers are still lacking. Preliminary data from the literature suggest that HNF1β may represent a sensitive marker of YST. The specificity of HNF1β has not been addressed in GCT. A cohort of 49 YST specimens from 45 patients was designed, occurring either as pure tumors, or as a component of a mixed GCT. Immunohistochemistry was conducted on whole tumor sections using HNF1β...
May 10, 2018: Human Pathology
Abdulkader M Albasri, Akbar S Hussainy
OBJECTIVES: To determine the histopathological pattern of testicular diseases among Saudi patients in Madinah, Saudi Arabia. METHODS: This retrospective histopathology-based study was conducted in a tertiary care hospital in Madinah, Saudi Arabia, from January 2006 to December 2017. The data collected were entered into MS-Excel and  analyzed using the Statistical Packages for Social Sciences Version 19. RESULTS: Of the 199 testicular specimens received, 108 (54...
May 2018: Saudi Medical Journal
Jeremy Lewin, Laleh Soltan Ghoraie, Philippe L Bedard, Robert J Hamilton, Peter Chung, Malcolm Moore, Michael A S Jewett, Lynn Anson-Cartwright, Carl Virtanen, Neil Winegarden, Julie Tsao, Padraig Warde, Joan Sweet, Benjamin Haibe-Kains, Aaron R Hansen
OBJECTIVES: To identify differentially expressed genes between relapsed (R) and non-relapsed (NR) clinical stage I (CSI) testicular germ cell tumor (TGCT). MATERIALS AND METHODS: We reviewed patients with CSI non-seminoma(NS) and seminoma(S) from an institutional database (2000-2012) managed by active surveillance. NR-NS and NR-S patients were defined as being relapse free after 2 and 3 years of surveillance respectively. RNA extraction and gene expression analysis was performed on archival primary tumor samples and Gene-Set-Enrichment-Analysis (GSEA) was conducted in order to identify differentiating biological pathways...
May 3, 2018: BJU International
Hideki Takeshita, Satoru Kawakami, Taro Takahara, Kojiro Tachibana, Shunsuke Hiranuma, Hironori Sugiyama, Makoto Kagawa, Akihiro Yano, Yohei Okada, Makoto Morozumi
Diffusion-weighted whole-body magnetic resonance imaging with background suppression (DWIBS) is increasingly used in cancer imaging. However, little is known about its usefulness in the management of metastatic seminoma, in which evaluation of the viability of postchemotherapy residual nodules is pivotal. To date, 2-18fluoro-deoxy-d-glucose positron emission tomography (FDG-PET) has been recommended for post-chemotherapeutic assessment. We describe a case of metastatic seminoma in a 27-year-old man in which the viability of post-chemotherapy residual nodules tested false-positive on FDG-PET, but true-negative on DWIBS...
2018: European Journal of Radiology Open
Dalibor Ondrus, Martina Ondrusova, Martin Suchansky
INTRODUCTION AND AIM: Survival of germ cell testicular cancer (TC) patients is better than for other malignancies and has not yet been exactly studied in the Slovak Republic. The aim of the study, based on the analyses of epidemiological data over time, was to present 5-year survival trends for germ cell TC patients. PATIENTS AND METHODS: Survival is assessed within the framework of a nation-wide retroprospective study among TC patients newly diagnosed between 1993-2007 (divided to three 5-year periods according the time of diagnosis - 1993-1997, 1998-2002 and 2003-2007)...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Robert Roskoski
The Kit proto-oncogene was found as the consequence of the discovery of the feline v-kit sarcoma oncogene. Stem cell factor (SCF) is the Kit ligand and it mediates Kit dimerization and activation. The Kit receptor contains an extracellular segment that is made up of five immunoglobulin-like domains (D1/2/3/4/5), a transmembrane segment, a juxtamembrane segment, a protein-tyrosine kinase domain that contains an insert of 77 amino acid residues, and a carboxyterminal tail. Activating somatic mutations in Kit have been documented in various neoplasms including gastrointestinal stromal tumors (GIST), mast cell overexpression (systemic mastocytosis), core-binding factor acute myeloid leukemias (AML), melanomas, and seminomas...
April 25, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Yuki Maruyama, Takuya Sadahira, Yosuke Mitsui, Motoo Araki, Koichiro Wada, Ryuta Tanimoto, Yasuyuki Kobayashi, Masami Watanabe, Toyohiko Watanabe, Yasutomo Nasu
Bleomycin pulmonary toxicity (BPT) has been well described in patients with germ cell tumors treated with bleomycin etoposide and cisplatin chemotherapy (BEP). To assess the prognostic impact of BPT, we retrospectively identified 52 patients who underwent bleomycin etoposide and cisplatin chemotherapy from 2008 to 2017 in our institution, and evaluated the risk factors of BPT and its effect on prognosis. Patients who had received chemotherapy at another institution were excluded. BPT was defined as bleomycin discontinuation in response to pulmonary function test decline, pulmonary symptoms, or interstitial pneumonia on computed tomography without infection...
April 26, 2018: Medical Oncology
Arlo Radtke, Finja Hennig, Raphael Ikogho, Johannes Hammel, Petra Anheuser, Christian Wülfing, Gazanfer Belge, Klaus-Peter Dieckmann
BACKGROUND: Accumulating evidence suggests serum levels of microRNA (miR)-371a-3p to be a novel tumour marker of testicular germ cell tumours (GCTs). Presently, there is only limited information regarding the velocity of decline of serum levels in response to treatment. PATIENTS AND METHODS: Twenty-four patients with testicular GCT (20 seminoma, 4 nonseminoma, median age 40 years) with clinical stage 1 had measurements of serum levels of miR-371a-3p preoperatively and repeatedly on the following 3 days...
April 26, 2018: Urologia Internationalis
Houssem Harbi, Amine Chaabouni, Rim Kallel, Nozha Toumi, Sami Fendri, Jihene Krichene, Salah Boujelbene, Rafik Mzali
Isolated macro-nodular liver tuberculosis is a very rare condition. It may mimic primitive or secondary tumors of the liver. This could delay or mislead the therapeutic management. An immunocompetent 48-year-old man with a history of non-metastatic seminoma was treated with right orchidectomy followed by 20 Gy radiotherapy. The discovery, 8 months later, of a 2 cm nodule of the hepatic dome evoked a liver metastasis. Percutaneous biopsy was not feasible. Wedge resection was performed whereas medical treatment would have sufficed, as pathologic examination of the resected specimen showed a macro-nodular hepatic tuberculosis...
April 1, 2018: Archives of Iranian Medicine
Bárbara Vilela-Salgueiro, Daniela Barros-Silva, João Lobo, Ana Laura Costa, Rita Guimarães, Mariana Cantante, Paula Lopes, Isaac Braga, Jorge Oliveira, Rui Henrique, Carmen Jerónimo
Testicular germ cell tumours (TGCTs) are a heterogeneous group of neoplasms, mostly affecting young men. Curability rates are high and adequate treatment relies on careful and accurate pathological and clinical assessment. Indeed, TGCTs' histopathological subtyping is critical for adequate therapeutic decision. Considering the limitation of currently available serum biomarkers, novel candidates have been proposed, most notably miR-371a-3p, which outperformed classical serum markers, but no detailed information concerning TGCT subtype was available...
June 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Seiji Shimada, Hidefumi Kinoshita, Takashi Yoshida, Kenta Takayasu, Takao Mishima, Kenji Yoshida, Masaaki Yanishi, Hidekazu Inui, Motohiko Sugi, Tadashi Matsuda
We report a patient with seminoma which recurred as late relapse at the pelvis with elevated alphafetoprotein (AFP) levels. A 40-year-old man presented with a left testicular tumor and subsequently underwent high orchiectomy in 2006. Pathological findings showed that the tumor was a seminoma with invasion into the tunica albuginea (pT2N0M0). Seven years after surgery, computed tomography showed a 12×8.7 mm, well-circumscribed, pelvic cystic tumor, and AFP and human chorionic gonadotropin levels were elevated...
March 2018: Hinyokika Kiyo. Acta Urologica Japonica
Deepak Kumar Diwakar, Nikita Wadhwani, Ravi Shekhar Pradhan, Ravi Prakash Verma
Cryptorchidism is associated with increased risk of malignancy and infertility. We present a case of a 30-year-old man who presented to the Emergency Department of our tertiary care hospital with spontaneous intra-abdominal rupture of the seminoma in undescended testis with hemoperitoneum. This is a rare presentation of seminoma and emphasises the importance of scrotal examination in young men presenting with acute abdomen. Surgical management is the definitive treatment and should be instituted as soon as possible, after appropriate resuscitation...
April 19, 2018: BMJ Case Reports
Ifeyinwa E Obiorah, Alexandra Kyrillos, Metin Ozdemirli
Leydig cell tumor is a rare sex cord tumor that accounts for 1-3% of all testicular neoplasms. Seminomas are more common and occur in 30-40% of testicular tumors. Leydig cell tumors are derived from undifferentiated gonadal mesenchyme and the concurrent development of the tumor and a seminoma which are derived from germinal epithelium in an ipsilateral testis is extremely rare. Here we report a case of ipsilateral Leydig cell tumor and seminoma occurring in a 38-year-old man with a left testicular mass. The key to diagnosis is dependent on histopathology and immunohistochemistry...
2018: Case Reports in Urology
Madhur Nayan, Robert J Hamilton
Testicular cancer is the most common malignancy in young men, and the incidence is increasing in most countries worldwide. The vast majority of patients present with clinical stage I disease, and surveillance is being increasingly adopted as the preferred management strategy. At the time of diagnosis, patients on surveillance are often counselled about their risk of relapse based on risk factors present at diagnosis, but this risk estimate becomes less informative in patients that have survived a period of time without experiencing relapse...
2018: Advances in Urology
Michael J Leveridge, D Robert Siemens, Kelly Brennan, Jason P Izard, Safiya Karim, Howard An, William J Mackillop, Christopher M Booth
BACKGROUND: Treatment guidelines for early-stage testicular cancer have increasingly recommended de-escalation of therapy with surveillance strategies. This study was designed to describe temporal trends in routine clinical practice and to determine whether de-escalation of therapy is associated with inferior survival in the general population. METHODS: The Ontario Cancer Registry was linked to electronic records of treatment to identify all patients diagnosed with testicular cancer treated with orchiectomy in Ontario during 2000-2010...
April 16, 2018: Cancer
Klaus-Peter Dieckmann, Hanna Richter-Simonsen, Magdalena Kulejewski, Raphael Ikogho, Henrik Zecha, Petra Anheuser, Uwe Pichlmeier, Hendrik Isbarn
INTRODUCTION: Clinical characteristics of testicular germ cell tumours (GCTs) apparently change over time, and some vary geographically. The aim of this study is to document the clinical profile of contemporary GCT patients. PATIENTS AND METHODS: Four hundred twenty-two Caucasian GCT-patients treated in one German centre during 2000-2017, were analysed in terms of patient-age, laterality, histology, tumour-size, clinical stages (CS), pathological (pT)-stages and serum biomarker expression...
April 12, 2018: Urologia Internationalis
Hoseok Lee, Jae-Kwang Lim, Sang Yub Lee, Kyung Min Shin
Primary mediastinal seminoma (PMS) is a rare tumor. PMS can be morphologically related to secondary changes in the form of thymic remnants, cystic degeneration, epithelioid granulomas, fibrotic change, and syncytiotrophoblast-like cells. Ours was an interesting case where a 26-year-old male presented with an incidentally-found anterior mediastinal mass. Even though he had no pulmonary symptoms, the transthoracic co-axial needle biopsy of the mass suggested tuberculosis (TB). However, on follow-up computed tomography (CT) and magnetic resonance image (MRI) in 2 months, the mass slightly increased in size, and a small part of low density or signal intensity appeared, despite the regular anti-TB treatment regimen...
February 2018: Journal of Thoracic Disease
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