Erik Reiche, Patrick R Keller, Vance Soares, Calvin R Schuster, Siti Rahmayanti, Jessica Mroueh, Vanessa Mroueh, Marie Billaud, Sophia Hu, Hunter Hoover-Watson, Christine G Lian, Yu Tan, Joshua C Doloff, Annie E Newell-Fugate, Devin Coon
Hypertrophic scarring is a major source of morbidity. Sex hormones are not classically considered modulators of scarring. However, based on increased frequency of hypertrophic scarring in patients on testosterone, we hypothesized that androgenic steroids induce abnormal scarring and developed a preclinical porcine model to explore these effects. Mini-swine underwent castration, received no testosterone (noT) or biweekly testosterone therapy (+T), and underwent excisional wounding. To create a delayed wound healing model, a subset of wounds were re-excised at 2 weeks...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology