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https://www.readbyqxmd.com/read/28742714/impact-of-extracapsular-lymph-node-involvement-after-neoadjuvant-chemoradiation-therapy-followed-by-surgery-in-carcinoma-of-the-esophagus-a-multicenter-study
#1
Lieven P Depypere, Johnny Moons, Christophe Mariette, Xavier B D'Journo, Pascal A Thomas, Arnulf H Hölscher, Elfriede Bollschweiler, Mark I van Berge-Henegouwen, Jan J B Van Lanschot, Toni E M R Lerut, Philippe R Nafteux
OBJECTIVES: The current study aims to examine the impact of extracapsular lymph node involvement (EC-LNI) on survival for both esophageal adenocarcinoma (AC) and squamous cell carcinoma (SCC) treated with neoadjuvant chemoradiation therapy (nCRT) followed by surgery. BACKGROUND: Studies have demonstrated the negative prognostic value of EC-LNI in primary surgery, but its impact after nCRT remains unclear. METHODS: From the databases of 6 European high-volume centers 1505 patients with R0 resections were withheld...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742698/survival-benefit-of-neoadjuvant-treatment-in-clinical-t3n0m0-esophageal-cancer-results-from-a-retrospective-multicenter-european-study
#2
Styliani Mantziari, Caroline Gronnier, Florence Renaud, Alain Duhamel, Jérémie Théreaux, Cécile Brigand, Nicolas Carrère, Jérémie H Lefevre, Arnaud Pasquer, Nicolas Demartines, Denis Collet, Bernard Meunier, Christophe Mariette
BACKGROUND: Based on current guidelines, clinical T3N0M0 esophageal tumors may or may not receive neoadjuvant treatment, according to their perception as locally advanced (cT3) or early-stage tumors (stage II). The study aim was to assess the impact of neoadjuvant treatment upon survival for cT3N0M0 esophageal cancer patients, with subgroup analyses by histological type (squamous cell carcinoma vs adenocarcinoma) and type of neoadjuvant treatment (chemotherapy vs radiochemotherapy). METHODS: Data from patients operated on for esophageal cancer in 30 European centers were collected...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742697/are-thoracotomy-and-or-intrathoracic-anastomosis-still-predictors-of-postoperative-mortality-after-esophageal-cancer-surgery-a-nationwide-study
#3
Sébastien Degisors, Arnaud Pasquer, Florence Renaud, Hélène Béhal, Flora Hec, Anne Gandon, Marguerite Vanderbeken, Gilbert Caranhac, Alain Duhamel, Guillaume Piessen, Christophe Mariette
BACKGROUND: Intrathoracic (vs cervical) anastomosis and a thoracotomy (vs absence) have previously been associated with increasing postoperative mortality (POM). Recent improvements in surgical practices and perioperative management may have changed these dogmas. OBJECTIVES: The aim of this study was to evaluate the impact of performing intrathoracic anastomosis and/or thoracotomy on POM after esophageal cancer surgery in recent years. METHODS: All consecutive patients who underwent esophageal cancer surgery with reconstruction between 2010 and 2012 in France were included (n = 3286)...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742691/impact-of-lymph-node-yield-on-overall-survival-in-patients-treated-with-neoadjuvant-chemoradiotherapy-followed-by-esophagectomy-for-cancer-a-population-based-cohort-study-in-the-netherlands
#4
Els Visser, Peter S N van Rossum, Jelle P Ruurda, Richard van Hillegersberg
OBJECTIVE: To evaluate the impact of lymph node yield (LNY) on survival in patients treated with neoadjuvant chemoradiotherapy (nCRT) followed by esophagectomy for cancer. BACKGROUND: The value of an extended lymphadenectomy after nCRT for esophageal cancer is debated. Recent reports demonstrate no association between LNY and survival. This association has not yet been evaluated in larger cohorts. METHODS: All patients who underwent nCRT followed by esophagectomy between 2005 and 2014 were identified from the Netherlands Cancer Registry...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742685/recurrence-patterns-and-long-term-results-after-induction-chemotherapy-chemoradiotherapy-and-curative-surgery-in-patients-with-locally-advanced-esophageal-cancer
#5
Thomas Steffen, Daniel Dietrich, Annelies Schnider, Christoph Kettelhack, Olivier Huber, Walter R Marti, Markus Furrer, Beat Gloor, Marc Schiesser, Sandra Thierstein, Peter Brauchli, Thomas Ruhstaller
OBJECTIVE: The long-term follow up data of 2 prospective phase II trials is reported (NCT00072033, NCT00445861), which investigated neoadjuvant chemoradiation followed by surgery in patients with esophageal carcinoma. Postoperative complications as well as prognostic factors and patterns of relapse during long-term observation are shown. SUMMARY OF BACKGROUND DATA: Long-term follow-up is often missing in the complex setting of multimodal treatments of esophageal carcinoma; this leads to rather undifferentiated follow-up guidelines for this tumor entity...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28741246/successful-resection-after-neoadjuvant-chemotherapy-for-esophageal-cancer-with-posterior-thoracic-paraaortic-lymph-node-metastasis-a-case-report-and-literature-review
#6
Yuji Shishido, Hiroshi Miyata, Keijirou Sugimura, Masaaki Motoori, Norikatsu Miyoshi, Masayoshi Yasui, Takeshi Omori, Masayuki Ohue, Yoshiyuki Fujiwara, Masahiko Yano
Metastasis to the posterior thoracic paraaortic lymph nodes rarely occurs in esophageal cancer, and a treatment strategy has not been established. We treated two cases of esophageal cancer with this type of metastasis; in both cases, we successfully performed surgical resection after neoadjuvant chemotherapy. In case 1, the patient received neoadjuvant chemotherapy, which consisted of docetaxel, cisplatin and 5-fluorouracil, and then underwent dissection of the posterior thoracic paraaortic lymph nodes. The left thoracic approach was used together with subtotal esophagectomy via a right thoracotomy...
July 24, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28740914/independent-test-of-a-model-to-predict-severe-acute-esophagitis
#7
Ellen X Huang, Clifford G Robinson, Alerson Molotievschi, Jeffrey D Bradley, Joseph O Deasy, Jung Hun Oh
PURPOSE: Treatment planning factors are known to affect the risk of severe acute esophagitis during thoracic radiation therapy. We tested a previously published model to predict the risk of severe acute esophagitis on an independent data set. METHODS AND MATERIALS: The data set consists of data from patients who had recoverable treatment plans and received definitive radiation therapy for non-small cell carcinoma of the lung at a single institution between November 2004 and January 2010...
January 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740892/chemoradiation-therapy-with-docetaxel-in-elderly-patients-with-stage-ii-iii-esophageal-cancer-a-phase-2-trial
#8
Akihiro Ohba, Ken Kato, Yoshinori Ito, Chikatoshi Katada, Hiromichi Ishiyama, Sachiko Yamamoto, Takashi Ura, Takeshi Kodaira, Shigehiro Kudo, Yoshio Tamaki
PURPOSE: The most effective treatments in elderly patients with esophageal cancer remain a subject of debate. This multicenter phase 2 study was designed to evaluate the efficacy and toxicity of chemoradiation therapy (CRT) with docetaxel (DTX) in elderly patients with stage II/III (non-T4) esophageal cancer. METHODS AND MATERIALS: Patients ≥70 years of age with clinical stage II/III esophageal cancer received DTX at a weekly dose of 10 mg/m(2) during 6 consecutive weeks and concurrent radiation therapy (60 Gy in 30 fractions)...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740891/esophageal-motion-characteristics-in-thoracic-esophageal-cancer-impact-of-clinical-stage-t4-versus-stages-t1-t3
#9
Yuta Kobayashi, Miyako Myojin, Shinichi Shimizu, Masao Hosokawa
PURPOSE: The main purpose was to investigate the differences of the esophageal motion (EM) and the internal target volume (ITV) margins for the esophagus between clinical T1-T3 (cT1-T3) and cT4 cases, using 4-dimensional computed tomography. A secondary purpose was to assess the metastatic lymph nodal motion (NM) and the ITV margins for lymph nodes (LNs) using the datasets of patients with nodal involvement pathologically defined. METHODS AND MATERIALS: We analyzed patients with thoracic esophageal cancer consecutively treated with definitive chemoradiation, measuring the EM and the ITV margins in the left-right, anteroposterior, and superoinferior directions...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740669/impact-of-thoracic-surgery-on-esophageal-motor-function-evaluation-by-high-resolution-manometry
#10
Anja Wäsche, Arne Kandulski, Peter Malfertheiner, Sandra Riedel, Patrick Zardo, Thomas Hachenberg, Jens Schreiber
BACKGROUND: Alteration of esophageal function is a potential risk factor for postoperative complications in thoracic surgery. This prospective study investigates esophageal motility and function during and after thoracic procedures via high resolution manometry (HRM) and impedance technology with spatiotemporal representation of pressure data. METHODS: Twelve consecutive patients eligible for elective thoracic surgery underwent preoperative and postoperative (48 hours and 7 days) esophageal HRM...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740655/editorial-on-role-of-p53-in-esophageal-cancer-from-a-meta-analysis-of-16-studies-by-fisher-et-al
#11
EDITORIAL
Francesca Steccanella, Antonio Costanzo, Fausto Petrelli
No abstract text is available yet for this article.
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740654/a-novel-therapeutic-approach-for-esophageal-squamous-cell-carcinoma-suppressor-of-cytokine-signaling-1-gene-therapy
#12
EDITORIAL
Chang-Han Chen, Shau-Hsuan Li
No abstract text is available yet for this article.
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740634/human-papillomavirus-and-gastrointestinal-cancer-in-iranian-population-a-systematic-review-and-meta-analysis
#13
REVIEW
Versa Omrani-Navai, Reza Alizadeh-Navaei, Yousef Yahyapour, Akbar Hedayatizadeh-Omran, Saeid Abediankenari, Ghasem Janbabaei, Fatima Toghani
BACKGROUND: Gastrointestinal (GI) malignancies are the most common cancers and account for nearly half of all cancer-related deaths in Iran. There was a strong association between human papillomavirus (HPV) infection and urogenital cancers, in particular the cervix. However, there is no clear causal relationship in all types of cancers, including gastrointestinal cancers. Therefore, the present study as a systematic review and meta-analysis was designed to evaluate the prevalence and relation of HPV in GI cancers...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28740506/comparison-of-inflammation-based-prognostic-scores-in-a-cohort-of-patients-with-resectable-esophageal-cancer
#14
G Jomrich, M Paireder, A Gleiss, I Kristo, L Harpain, S F Schoppmann
BACKGROUND: A number of studies have revealed that inflammation-based prognostic scores, such as Glasgow prognostic score (GPS), modified Glasgow prognostic score (mGPS), and C-reactive protein and albumin ratio (C/A ratio), are associated with poor outcome in cancer patients. However, until now, no study has investigated the role of these prognostic scores in a cohort of neoadjuvant-treated esophageal adenocarcinomas (nEAC) and squamous cell carcinomas (nESCC). METHODS: Patients had laboratory measurements within three days before resection...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28740353/anti-apoptotic-effect-of-banhasasim-tang-on-chronic-acid-reflux-esophagitis
#15
Mi-Rae Shin, Hyo-Jin An, Bu-Il Seo, Seong-Soo Roh
AIM: To evaluate the anti-apoptotic effect of banhasasim-tang (BHSST) on chronic acid reflux esophagitis (CARE) using a rat model. METHODS: A surgically-induced CARE model was established in Sprague-Dawley rats. The modeled rats were divided into a treatment group or untreated group, and given BHSST (1 g/kg body weight per day) or water, respectively, for 15 consecutive days (n = 7 each group). Changes in expression of proteins related to nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and apoptosis were assessed by western blotting...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28739765/relationship-of-th17-treg-cells-and-radiation-pneumonia-in-locally-advanced-esophageal-carcinoma
#16
Yan Wang, Gang Xu, Jie Wang, Xin-Hua Li, Ping Sun, Wei Zhang, Jun-Xia Li, Chao-Yang Wu
BACKGROUND/AIM: Radiation pneumonia is a main side-effect that has limited the clinical usage of radiotherapy in locally advanced esophageal carcinoma. T helper cells 17 (Th 17) and T regulatory cells (Tregs) play an important role in inflammatory diseases. The balance between Treg and Th17 cells is a key factor in the progression of many inflammatory and autoimmune diseases. Whether Tregs and Th17 cells are predictive factors of radiation pneumonia has not yet been reported. In this study, we investigated the relationships of Treg/Th17 cells and radiation pneumonia in patients with locally advanced esophageal cancer who received radiotherapy...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739705/metabolic-rather-than-pathological-response-to-preoperative-chemoradiotherapy-is-a-stronger-predictor-of-survival-in-cstage-iib-iv-esophageal-cancer
#17
Satoru Motoyama, Yusuke Sato, Kiyotomi Maruyama, Shuetsu Usami, Kei Yoshino, Toshinobu Nakatsu, Tomohiko Sasaki, Akiyuki Wakita, Yuta Kawakita, Jiajia Liu, Akira Anbai, Kouichi Ishiyama, Hajime Saito, Yoshihiro Minamiya
AIM: We investigated which is the stronger predictor, pathological response or metabolic response, for survival outcome in patients treated with neoadjuvant chemoradiotherapy (NACRT) plus esophagectomy for thoracic esophageal squamous cell carcinoma (TESCC). PATIENTS AND METHODS: Fifty consecutive patients with cStage IIB-IV TESCC were enrolled. We analyzed the pathological response and metabolic response (fractional decrease in tumor maximum standardized uptake value) to NACRT...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739699/clinical-significance-and-phenotype-of-mta1-expression-in-esophageal-squamous-cell-carcinoma
#18
Hiroaki Honjo, Yasushi Toh, Makoto Sohda, Shigemasa Suzuki, Kyoichi Kaira, Yoshikatsu Kanai, Shushi Nagamori, Tetsunari Oyama, Takehiko Yokobori, Tatsuya Miyazaki, Hiroyuki Kuwano
BACKGROUND/AIM: Metastasis-associated gene 1 (MTA1) is considered a potential prognostic factor in esophageal cancer. We investigated the clinical relationship between MTA1, LAT1, and tumor metabolism, as evaluated by positron emission tomography (PET) in esophageal squamous cell carcinoma. MATERIALS AND METHODS: We analyzed 142 esophageal squamous cell carcinoma patients who underwent curative resection without preoperative treatment. MTA1 expression was assessed by immuno-zahistochemistry, and tested against standardized uptake values from preoperative PET-CT...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739249/intraperitoneal-pressure-in-peritoneal-dialysis
#19
Vicente Pérez Díaz, Sandra Sanz Ballesteros, Esther Hernández García, Elena Descalzo Casado, Irene Herguedas Callejo, Cristina Ferrer Perales
The measure of intraperitoneal pressure in peritoneal dialysis is easy and provides clear therapeutic benefits. However it is measured only rarely in adult peritoneal dialysis units. This review aims to disseminate the usefulness of measuring intraperitoneal pressure. This measurement is performed in supine before initiating the drain of a manual exchange with "Y" system, by raising the drain bag and measuring from the mid-axillary line the height of the liquid column that rises from the patient. With typical values of 10-16 cmH2O, intraperitoneal pressure should never exceed 18 cmH2O...
July 21, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28739092/numeric-pathologic-lymph-node-classification-shows-prognostic-superiority-to-topographic-pn-classification-in-esophageal-squamous-cell-carcinoma
#20
Kotaro Sugawara, Hiroharu Yamashita, Yukari Uemura, Takashi Mitsui, Koichi Yagi, Masato Nishida, Susumu Aikou, Kazuhiko Mori, Sachiyo Nomura, Yasuyuki Seto
BACKGROUND: The current eighth tumor node metastasis lymph node category pathologic lymph node staging system for esophageal squamous cell carcinoma is based solely on the number of metastatic nodes and does not consider anatomic distribution. We aimed to assess the prognostic capability of the eighth tumor node metastasis pathologic lymph node staging system (numeric-based) compared with the 11th Japan Esophageal Society (topography-based) pathologic lymph node staging system in patients with esophageal squamous cell carcinoma...
July 21, 2017: Surgery
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