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https://www.readbyqxmd.com/read/28531452/the-effect-of-glutamine-and-arginine-enriched-nutritional-support-on-quality-of-life-in-head-and-neck-cancer-patients-treated-with-imrt
#1
Sezin Yuce Sari, Gozde Yazici, Deniz Yuce, Erdem Karabulut, Mustafa Cengiz, Gokhan Ozyigit
BACKGROUND AND AIMS: Oral mucositis and esophagitis are common acute toxicities of radiotherapy (RT) for head and neck cancer (HNC). In order to decrease the rates of these toxicities, we compared quality of life in HNC patients that did and did not receive a glutamine and arginine-enriched solution (GAES) during RT. METHODS: A total of 29 patients received intensity-modulated radiotherapy (IMRT); 15 used GAES b.i.d. during the treatment, and a matched cohort of 14 patients did not...
December 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531216/impact-of-mutations-in-toll-like-receptor-pathway-genes-on-esophageal-carcinogenesis
#2
Daffolyn Rachael Fels Elliott, Juliane Perner, Xiaodun Li, Martyn F Symmons, Brett Verstak, Matthew Eldridge, Lawrence Bower, Maria O'Donovan, Nick J Gay, Rebecca C Fitzgerald
Esophageal adenocarcinoma (EAC) develops in an inflammatory microenvironment with reduced microbial diversity, but mechanisms for these influences remain poorly characterized. We hypothesized that mutations targeting the Toll-like receptor (TLR) pathway could disrupt innate immune signaling and promote a microenvironment that favors tumorigenesis. Through interrogating whole genome sequencing data from 171 EAC patients, we showed that non-synonymous mutations collectively affect the TLR pathway in 25/171 (14...
May 22, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28530783/a-rare-case-of-obscure-gastrointestinal-bleeding-small-bowel-varices-flowing-into-the-inferior-epigastric-vein
#3
Akira Hoshiai, Junya Tsurukiri, Yasuhiro Sumi
Ectopic varices include all varices except esophageal or gastric varices and comprise large portosystemic venous collaterals that occur anywhere in the abdomen. Ectopic varices are relatively rare; however, approximately 5% are related to gastrointestinal bleeding. Ectopic varices usually occur in the rectum, duodenum, or colon, and portal hypertension is the most common cause. Hemodynamic profiles of ectopic varices remain unknown, and extensive bleeding from these structures occurs because diagnosis and treatment are difficult...
May 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28530769/beneficial-effects-of-garlic-allium-sativum-oil-in-experimental-corrosive-esophageal-burns-effects-of-garlic-oil-in-esophageal-burns
#4
Ceren Şen Tanrıkulu, Yusuf Tanrikulu, Fahriye Kılınç, Burak Bahadır, Murat Can, Füruzan Köktürk
BACKGROUND: Corrosive esophageal burns, particularly common in developing countries, lead to different problems in different age groups. The ingestion of corrosive substances can cause such problems as stricture of the esophagus, to acute perforation, and even death. Because stricture formation is related to the severity of the initial injury, the prevention of stricture constitutes a main goal of treatment. The aim of this study was to investigate the protective and anti-inflammatory effects of garlic (Allium sativum) oil in corrosive esophageal burn...
May 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28530542/a-comparison-of-the-toxicity-of-mono-bis-tris-and-tetrakis-phosphino-silver-complexes-on-sno-esophageal-cancer-cells
#5
Zelinda Engelbrecht, Kariska Potgieter, Zenele Mpela, Rehana Malgas-Enus, Reinout Meijboom, Marianne J Cronje
Several silver(I) triphenylphosphine adducts were prepared as 1:1 to 1:4 ratios of silver nitrate to triphenylphosphine were used to determine their anticancer activity in a malignant SNO esophageal cell line. The silver-phosphine adducts include: [Ag(PPh3)]NO3 (1); [Ag(PPh3)2]NO3 (2); [Ag(PPh3)3]NO3 (3) and [Ag(PPh3)4]NO3 (4). In addition, the activity of 1-4 where compared to previously reported complexes [Ag(Ph2P(CH2)2PPh2)2]NO3 (5) and [Ag(Ph2P(CH2)3PPh2)2]NO3 (6). The cytotoxicity of complexes 1 to 6 was also evaluated in non-malignant human dermal fibroblast cells (HDF-a)...
May 22, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28529620/the-relation-of-hpv-infection-and-expression-of-p53-and-p16-proteins-in-esophageal-squamous-cells-carcinoma
#6
Paula Roberta Aguiar Pastrez, Vânia Sammartino Mariano, Allini Mafra da Costa, Estela Maria Silva, Cristovam Scapulatempo-Neto, Denise Peixoto Guimarães, Gilberto Fava, Said Abdala Zemi Neto, Emily Montosa Nunes, Laura Sichero, Luisa Lina Villa, Kari Juhani Syrjanen, Adhemar Longatto-Filho
GOAL: To investigate the HPV prevalence and characterize the expression of potential molecular surrogate markers of HPV infection in esophageal squamous cell carcinoma. MATERIALS AND METHODS: The prevalence of HPV in individuals with and without esophageal cancer (EC) was determined by using multiplex PCR; p16 and p53 protein levels were assessed by immunohistochemistry (IHC). RESULTS: High-risk HPV (hr-HPV) was found in the same frequency (13.8%) in esophageal squamous cell carcinoma (ESCC) and in healthy individuals...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28529615/a-novel-blood-tool-of-cancer-prognosis-in-esophageal-squamous-cell-carcinoma-the-fibrinogen-albumin-ratio
#7
Zihui Tan, Man Zhang, Qiang Han, Jing Wen, Kongjia Luo, Peng Lin, Lanjun Zhang, Hong Yang, Jianhua Fu
Background: Coagulation and nutrition play important roles in cancer progression. We aim to investigate the impact of the fibrinogen/albumin ratio(FAR) in esophageal squamous cell carcinoma (ESCC) patients. Methods: We retrospectively analyzed 1135 patients with radical esophagectomy for ESCC from January 2008 to December 2010 in our center. X-tile software was used to determine the optimal cutoff levels for these biomarkers. Results: The optimal cutoff value was 0.08 for the FAR by the X-tile software. The FAR was statistically significantly associated with age(p=0...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28529610/foretinib-enhances-the-radiosensitivity-in-esophageal-squamous-cell-carcinoma-by-inhibiting-phosphorylation-of-c-met
#8
Guang-Zong Chen, Wang-Shu Dai, Hong-Cheng Zhu, Hong-Mei Song, Xi Yang, Yuan-Dong Wang, Hua Min, Qian Lu, Shu Liu, Xin-Chen Sun, Xiao-Ning Zeng
As a crucial event involved in the metastasis and relapse of esophageal cancer, c-Met overexpression has been considered as one of the culprits responsible for the failure in patients who received radiochemotherapy. Since c-Met has been confirmed to be pivotal for cell survival, proliferation and migration, little is known about its impact on the regulation of radiosensitivity in esophageal cancer. The present study investigated the radiosensitization effects of c-Met inhibitor foretinib in ECA-109 and TE-13 cell lines...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28529564/synthesis-characterization-and-anticancer-activities-of-transition-metal-complexes-with-a-nicotinohydrazone-ligand
#9
Shanshan Shen, Hong Chen, Taofeng Zhu, Xiuqin Ma, Jun Xu, Wenjiao Zhu, Ruhua Chen, Jing Xie, Tieliang Ma, Lei Jia, Yuan Wang, Chunyan Peng
The reaction of divalent transition metal salts and (E)-N'-(1-(pyridin-2-yl)ethylidene)nicotinohydrazide (penh) led to the formation of [Mn(penh)2] (complex 1), [Co(penh)2] (complex 2), [Cu(penh)2] (complex 3) and [Cd (penh)2] (complex 4) complexes. The four complexes were characterized using elemental analyses, infrared spectra and single-crystal X-ray diffraction analyses. Subsequently, the complexes were used for in vitro cell level experiments to determine potential antitumor effects. The results demonstrated that the complexes exhibited a similar structure; however, they were crystallized with distinct space groups...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28529190/development-and-evaluation-of-an-interdisciplinary-postoperative-support-program-in-outpatient-clinics-after-thoracic-esophagectomy
#10
Takeo Fujita, Yoko Iida, Chihau Tanaka, Kumi Nakamura, Keiko Yamanaka, Junya Ueno, Yoshie Iino, Chitose Haruka, Hatoe Sakamoto, Hiroyuki Daiko
BACKGROUND: To support patients discharged from the hospital after surgery, we launched an "Interdisciplinary Postoperative Support Program" in outpatient clinics for patients who were discharged within 1 month after thoracic esophagectomy and their families. We introduce our program and clarify the patient's physical and psychologic status by analyzing the questionnaire provided from this program. MATERIALS AND METHODS: From August 2014 to January 2015, we conducted the Interdisciplinary Postoperative Support Program every month...
May 18, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28528706/long-noncoding-rnas-in-the-pathogenesis-of-barrett-s-esophagus-and-esophageal-carcinoma
#11
REVIEW
John M Abraham, Stephen J Meltzer
For many years, only a small fraction of the human genome was believed to regulate cell function and development. This protein-coding portion composed only 1% to 2% of 3 billion human DNA base pairs-the remaining sequence was classified as junk DNA. Subsequent research has revealed that most of the genome is transcribed into a broad array of noncoding RNAs, ranging in size from microRNA (20-23 nucleotides) to long noncoding RNA (lncRNA, more than 200 nucleotides). These noncoding RNA classes have been shown to use diverse molecular mechanisms to control gene expression and organ system development...
May 18, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28528491/high-resolution-manometry-evaluation-of-pressures-at-the-pharyngo-upper-esophageal-area-in-patients-with-oropharyngeal-dysphagia-due-to-vagal-paralysis
#12
Bruno Rezende Pinna, Fernando A M Herbella, Noemi de Biase, Thays C G Vaiano, Marco G Patti
The motility of the pharynx, upper esophageal sphincter (UES), and proximal esophagus in patients with oropharyngeal dysphagia is still not entirely understood. High-resolution manometry (HRM) was recently added to the armamentarium for the study of this area. This study aims to describe HRM findings in patients with vagal paralysis. Sixteen patients (mean age 54 years, 69% females) with oropharyngeal dysphagia due to unilateral vagal paralysis were prospectively studied. All patients underwent HRM. Motility of the UES and at the topography of the velopharynx and epiglottis were recorded...
May 20, 2017: Dysphagia
https://www.readbyqxmd.com/read/28528074/skin-perforator-flap-pedicled-by-intercostal-muscle-for-repair-of-a-tracheobronchoesophageal-fistula
#13
Nicolas Bertheuil, Caterina Cusumano, Cécile Meal, Yann Harnoy, Eric Watier, Bernard Meunier
A tracheobronchial fistula (TBF) is a rare complication when an operation is performed to treat esophageal carcinoma; no consensus treatment strategy has emerged. We describe a surgical interposition strategy, using a new flap, to repair a TBF that arose when esophageal squamous cell carcinoma was treated with neoadjuvant chemoradiation and minimally invasive esophagectomy (the 3-stage McKeown procedure). We performed a skin perforator flap pedicled by the intercostal muscle. It is a valuable option that may be the optimal first-line treatment, especially in the context of neoadjuvant radiation therapy...
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28528063/an-involuntary-and-unexpected-treatment-of-nutcracker-esophagus
#14
Diane Mege, Alban Benezech, Henri de Lesquen, Véronique Vitton, Pascal-Alexandre Thomas
A 76-year-old woman complained of painful dysphagia and loss of weight. Esophagoscopy results were negative, whereas computed tomography (CT) disclosed a 25-mm mediastinal tumor without a connection to the esophagus. A diagnosis of nutcracker esophagus was made on high-resolution esophageal manometry. Peroral endoscopic esophageal myotomy failed to improve the symptoms. Right video thoracoscopy allowed resection of the tumor, which looked like a neurogenic tumor of the posterior mediastinum that developed from the right vagus nerve...
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28528056/esophageal-bronchus
#15
Raghav Murthy, John Lamberti, Nicholas Saenz
Communicating bronchopulmonary foregut malformations are uncommon anomalies. This report describes a case of "esophageal bronchus" managed successfully in a newborn with a nearly total pneumonectomy.
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28528055/pseudoachalasia-secondary-to-thoracic-aortic-aneurysm
#16
Jorind Beqari, Anthony Lembo, Jon Critchlow, Allen Hamden, Michael S Kent
Pseudoachalasia is known to be associated with malignancy involving the gastroesophageal junction and after esophageal operations. We present a case of pseudoachalasia secondary to an aneurysm of the descending thoracic aorta and describe successful operative management.
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28528013/congenital-h-type-tracheoesophageal-fistula-a-multicenter-review-of-outcomes-in-a-rare-disease
#17
Sara C Fallon, Jacob C Langer, Shawn D St Peter, KuoJen Tsao, Caroline M Kellagher, Dave R Lal, Jill S Whitehouse, Diana L Diesen, Michael D Rollins, Elizabeth Pontarelli, Marcus M Malek, Corey W Iqbal, Jeffrey S Upperman, Charles M Leys, Mark L Wulkan, Sarah J Hill, Martin L Blakely, Timothy D Kane, David E Wesson
OBJECTIVE: To perform a multicenter review of outcomes in patients with H-type tracheoesophageal fistula (TEF) in order to better understand the incidence and causes of post-operative complications. BACKGROUND: H-type TEF without esophageal atresia (EA) is a rare anomaly with a fundamentally different management algorithm than the more common types of EA/TEF. Outcomes after surgical treatment of H-type TEF are largely unknown, but many authoritative textbooks describe a high incidence of respiratory complications...
May 11, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28527963/clinical-significance-of-spontaneous-pneumomediastinum
#18
Brittany A Potz, Linda H Chao, Thomas T Ng, Ikenna C Okereke
BACKGROUND: Spontaneous pneumomediastinum (SPM) is classified as free air in the mediastinum in the absence of any precipitating cause. It is relatively uncommon, and the clinical significance and risk associated with SPM is not well understood and has not been widely documented in the literature. Our goals were to determine the outcomes of patients who presented with SPM and to determine predictors of severe pathology associated with SPM. METHODS: From 2004 through 2013, a retrospective review was conducted of patients who presented with SPM to our institution...
May 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28527619/chemoradiotherapy-for-esophageal-cancer-before-or-after-surgery-it-is-not-just-a-matter-of-time
#19
EDITORIAL
Simon R Turner, Daniela Molena
No abstract text is available yet for this article.
April 28, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28527023/-high-resolution-manometry-of-pharyngeal-swallowing-dynamics
#20
REVIEW
M Jungheim, M Ptok
BACKGROUND: To transport a bolus from the mouth into the stomach, regular contraction of the pharyngeal muscles and a coordinated function of the upper esophageal sphincter (UES) are necessary. The muscle contraction generates intraluminal pressure, which pushes the bolus continuously forward. In contrast to imaging studies, manometric methods enable assessment of intraluminal pressure buildup and the function of the muscles involved. These methods were initially established for the esophagus and have been used increasingly in the pharynx for 7-8 years...
May 19, 2017: HNO
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