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Iron hemodialysis

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https://www.readbyqxmd.com/read/29742267/epoetin-alfa-resistance-in-hemodialysis-patients-with-chronic-kidney-disease-a-longitudinal-study
#1
E J F Santos, E V Hortegal, H O Serra, J S Lages, N Salgado-Filho, A M Dos Santos
Anemia is an inevitable complication of hemodialysis, and the primary cause is erythropoietin deficiency. After diagnosis, treatment begins with an erythropoiesis-stimulating agent (ESA). However, some patients remain anemic even after receiving this medication. This study aimed to investigate the factors associated with resistance to recombinant human erythropoietin therapy with epoetin alfa (αEPO). We performed a prospective, longitudinal study of hemodialysis patients receiving treatment with αEPO at our reference hospital from July 2015 to June 2016...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29734151/renal-anemia-and-iron-metabolism
#2
Chie Ogawa, Ken Tsuchiya, Kunimi Maeda, Kosaku Nitta
Normal iron metabolism is essential for effective hemoglobin (Hb) production in the management of renal anemia. Considering that studies regarding the optimal Hb levels predated the creation of the iron management indices found in the treatment guidelines for hemodialysis (HD) patients, an increase in the Hb levels caused by intravenous iron supplementation has been used as an iron management index. However, no consideration was given to iron metabolism or the long-term safety of intravenous iron supplementation...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29725640/oral-ferric-citrate-hydrate-associated-with-less-oxidative-stress-than-intravenous-saccharated-ferric-oxide
#3
Masaaki Nakayama, Yoshihiro Tani, Wan-Jun Zhu, Kimio Watanabe, Keitaro Yokoyama, Masafumi Fukagawa, Takashi Akiba, Myles Wolf, Hideki Hirakata
Introduction: A recent study suggested that orally dosed ferric citrate hydrate (FC) corrects renal anemia in patients on hemodialysis (HD), suggesting biological differences in effects of iron supplementation using different routes of administration. To address this issue, the present study compared oral FC with i.v. saccharated ferric oxide (FO) in stable HD patients. Methods: Participants comprised 6 patients administered 3 consecutive protocols in the first HD session of the week in a fasting state: nothing given, as control (C); oral load of FC (480 mg iron), and 5 minutes of i...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29707087/elevated-neutrophil-gelatinase-lipocalin-levels-are-associated-with-increased-oxidative-stress-in-hemodialysis-patients
#4
Adam Nevo, Zaher Armaly, Amir Abd El Kadir, Amos Douvdevani, David Tovbin
Background: Administration of intravenous iron is an essential treatment of anemia in hemodialysis patients, but it may lead to oxidative stress and increased morbidity and mortality. There is evidence that neutrophil gelatinase-associated lipocalin (NGAL) is protective against oxidative stress and thus the aim of the present study was to investigate the relationship between plasma NGAL and advanced oxidative protein products (AOPP) in hemodialysis patients treated with intravenous iron...
June 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29703633/oral-versus-intravenous-iron-supplementation-for-the-treatment-of-iron-deficiency-anemia-in-patients-on-maintenance-hemodialysis-effect-on-fibroblast-growth-factor-23-metabolism
#5
Wataru Fukao, Yukiko Hasuike, Tomo Yamakawa, Kazuhiro Toyoda, Makoto Aichi, Satoko Masachika, Mari Kantou, Shoko Ikeda Takahishi, Takahide Iwasaki, Mana Yahiro, Masatoshi Nanami, Yasuyuki Nagasawa, Takahiro Kuragano, Takeshi Nakanishi
OBJECTIVE: Iron administration affects serum levels of intact (I-) fibroblast growth factor-23 (FGF23) and its cleavage product C-terminal (C-) FGF23 in iron-deficient patients on maintenance hemodialysis (MHD). The objective of this study was to compare the effect of oral or intravenous iron administration on serum levels of I-FGF23 and C-FGF23 in iron-deficient patients on MHD. DESIGN AND METHODS: A prospective randomized study. SUBJECTS: Participants on MHD with severe iron deficiency (n = 61)...
April 24, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29703387/food-drug-interactions-precipitated-by-fruit-juices-other-than-grapefruit-juice-an-update-review
#6
REVIEW
Meng Chen, Shu-Yi Zhou, Erlinda Fabriaga, Pian-Hong Zhang, Quan Zhou
This review addressed drug interactions precipitated by fruit juices other than grapefruit juice based on randomized controlled trials (RCTs). Literature was identified by searching PubMed, Cochrane Library, Scopus and Web of Science till December 30 2017. Among 46 finally included RCTs, six RCTs simply addressed pharmacodynamic interactions and 33 RCTs studied pharmacokinetic interactions, whereas seven RCTs investigated both pharmacokinetic and pharmacodynamic interactions. Twenty-two juice-drug combinations showed potential clinical relevance...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29699506/correction-to-the-ferumoxytol-for-anemia-of-ckd-trial-fact-a-randomized-controlled-trial-of-repeated-doses-of-ferumoxytol-or-iron-sucrose-in-patients-on-hemodialysis-background-and-rationale
#7
Iain C Macdougall, Naomi V Dahl, Kristine Bernard, Zhu Li, Alka Batycky, William E Strauss
Following publication of the original article [1], the authors reported that one of the authors' name is spelled incorrectly. In this Erratum the incorrect and correct author name are shown. The original publication of this article has been corrected.
April 26, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29692934/a-web-based-platform-to-collect-data-from-esrd-patients-undergoing-dialysis-methods-and-preliminary-results-from-the-brazilian-dialysis-registry
#8
Jocemir R Lugon, Pedro A Gordan, Fernando S Thomé, Antonio A Lopes, Yoshimi J A Watanabe, Carmen Tzanno, Ricardo C Sesso
Introduction: The methods and initial results of a web-based platform to collect data from patients receiving maintenance dialysis in Brazil are reported. Methods: Companies providing management software for dialysis centers adapted their system to comply with a formulary of the Brazilian Society of Nephrology. Baseline and follow-up individual patients' data were transmitted via Internet on monthly bases to the coordinating center from 2011 to 2017. Results: 73 dialysis centers provided information of 24,930 patients: 57% were male, 28% were 64 years old or older, and 13% were overweight/obese...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29608808/an-unusual-cause-of-gastrointestinal-bleeding-in-a-hemodialysis-patient
#9
Julien Aron, Aymeric Couturier, Leila Sinayoko, Viviane Duedal, Christophe Ridel, Maxime Touzot
Iron deficiency caused by gastrointestinal (GI) bleeding is a common cause of anemia in hemodialysis patient. Herein, we report the case of an 89-year-old hemodialysis patient who presented with acute anemia and melena. Endoscopy found gastritis and diverticulosis without active bleeding. A capsule endoscopy (CE) was then performed and revealed multiple vascular lesions that lead to the diagnosis of Blue Rubber Bleb Nevus syndrome (BRBNS). This rare disease is associated with multiple venous malformations in the skin and the GI tract, usually observed in children...
April 2, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29600410/butyrylcholinesterase-level-as-an-independent-factor-of-erythropoiesis-stimulating-agent-resistance-in-patients-on-maintenance-hemodialysis-a-single-center-cross-sectional-study
#10
Teppei Okamoto, Shingo Hatakeyama, Yoshimi Tanaka, Kengo Imanishi, Tooru Takashima, Fumitada Saitoh, Takuya Koie, Tadashi Suzuki, Chikara Ohyama
BACKGROUND: Erythropoiesis-stimulating agent (ESA) responsiveness is related to the nutritional status of patients on hemodialysis (HD). Serum butyrylcholinesterase (BChE), an alpha-glycoprotein, may decrease in case of malnutrition. We investigated whether BChE was independently related to ESA resistance in patients on HD. METHODS: The laboratory data and ESA resistance index (ERI), defined as ESA dosage per week divided by dry weight and hemoglobin, were investigated in 215 patients on HD between July and September 2017...
March 29, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29596361/optimal-serum-ferritin-levels-for-iron-deficiency-anemia-during-oral-iron-therapy-oit-in-japanese-hemodialysis-patients-with-minor-inflammation-and-benefit-of-intravenous-iron-therapy-for-oit-nonresponders
#11
Kazuya Takasawa, Chikako Takaeda, Takashi Wada, Norishi Ueda
Background: We determined optimal serum ferritin for oral iron therapy (OIT) in hemodialysis (HD) patients with iron deficiency anemia (IDA)/minor inflammation, and benefit of intravenous iron therapy (IIT) for OIT-nonresponders. Methods: Inclusion criteria were IDA (Hb <120 g/L, serum ferritin <227.4 pmol/L). Exclusion criteria were inflammation (C-reactive protein (CRP) ≥ 5 mg/L), bleeding, or cancer. IIT was withheld >3 months before the study. ΔHb ≥ 20 g/L above baseline or maintaining target Hb (tHB; 120-130 g/L) was considered responsive...
March 29, 2018: Nutrients
https://www.readbyqxmd.com/read/29565167/metabolic-inflammatory-and-oxidative-stress-markers-in-the-nitric-oxide-variation-of-hemodialysis-subjects
#12
Andreza De Paula Santos Epifânio, Karla Pereira Balbino, Monica De Paula Jorge, Sonia M R Ribeiro, Ana Vládia Bandeira Moreira, Jerusa Maria Oliveira, Leandro Licursi Oliveira, Helen Hermana Miranda Hermsdorff
INTRODUCTION: Oxidative stress markers such as nitric oxide (NO) have been investigated in hemodialysis (HD). OBJECTIVE: Evaluate the association of NO variation with adiposity indicators, metabolic, inflammatory and oxidative stress markers in individuals to HD. METHODS: Cross-sectional study with 85 subjects on HD treatment (≥ 18 years). The clinical-nutritional status was evaluated through subjective global assessment modified (SGAm), anthropometric measurements and body composition...
January 10, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29536389/rationale-design-and-characteristics-of-a-trial-to-evaluate-the-new-phosphate-iron-based-binder-sucroferric-oxyhydroxide-in-dialysis-patients-with-the-goal-of-advancing-the-practice-of-e-b-m-episode
#13
Yoshitaka Isaka, Hideki Fujii, Yoshihiro Tsujimoto, Satoshi Teramukai, Takayuki Hamano
BACKGROUND: In dialysis patients, mortality risk due to cardiovascular diseases is remarkably high and prognosis is poor; coronary artery calcification is considered one of the major contributing factors. It is known that hyperphosphatemia is associated with coronary artery calcification. Therefore, controlling serum phosphate level and thereby mitigating vascular calcification could improve the poor prognosis of dialysis patients. However, the optimal phosphate level in dialysis patients remains unknown; hence, this study was planned to compare the effects of two types of non-calcium-based phosphate binders, and examine the effect of strict control of phosphate on coronary artery calcification...
March 13, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29456218/renal-anemia-syndromes-in-iraqi-hemodialysis-patients-according-to-iron-status
#14
Ala Ali, Riyadh M Salih
Anemia is common in patients on hemodialysis (HD). Adequate iron stores are essential for achieving the best hemoglobin level through maximum benefit from erythropoiesis-stimulating agents (ESA). Decreased iron stores or decreased availability of iron are the most common reasons for resistance to the effect of these agents. Our objective was to categorize a group of Iraqi HD patients according to absolute or functional iron deficiency anemia (IDA); this study was conducted in the HD unit of the Baghdad Teaching Hospital from October 2012 to January 2013...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29439253/positive-iron-balance-in-chronic-kidney-disease-how-much-is-too-much-and-how-to-tell
#15
Jay B Wish, George R Aronoff, Bruce R Bacon, Carlo Brugnara, Kai-Uwe Eckardt, Tomas Ganz, Iain C Macdougall, Julio Núñez, Adam J Perahia, John C Wood
BACKGROUND: Regulation of body iron occurs at cellular, tissue, and systemic levels. In healthy individuals, iron absorption and losses are minimal, creating a virtually closed system. In the setting of chronic kidney disease and hemodialysis (HD), increased iron losses, reduced iron absorption, and limited iron availability lead to iron deficiency. Intravenous (IV) iron therapy is frequently prescribed to replace lost iron, but determining an individual's iron balance and stores can be challenging and imprecise, contributing to uncertainty about the long-term safety of IV iron therapy...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29366423/therapeutic-approach-to-patients-with-heart-failure-with-reduced-ejection-fraction-and-end-stage-renal-disease
#16
Chakradhari Inampudi, Paulino Alvarez, Rabea Asleh, Alexandros Briasoulis
BACKGROUND: Several risk factors including Ischemic heart disease, uncontrolled hypertension, high output Heart Failure (HF) from shunting through vascular hemodialysis access, and anemia, contribute to development of HF in patients with End-Stage Renal Disease (ESRD). Guidelinedirected medical and device therapy for Heart Failure with Reduced Ejection Fraction (HFrEF) has not been extensively studied and may have limited safety and efficacy in patients with ESRD. RESULTS: Maintenance of interdialytic and intradialytic euvolemia is a key component of HF management in these patients but often difficult to achieve...
March 14, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29359355/influence-of-carnicor-venofer-and-sevelamer-on-the-levels-of-genotoxic-damage-in-end-stage-renal-disease-patients
#17
Susana Pastor, Elisabeth Coll, Lara Rodríguez-Ribera, Elitsa Stoyanova, Zuray F Corredor, Ricard Marcos
End-stage renal disease (ESRD) patients present high levels of phosphorus and calcium products in serum, which contribute to the development of vascular calcification and cardiovascular disease, and to low iron stores and carnitine deficiency. For these reasons, ESRD patients are generally supplemented with different medicines. Some of the most common treatments include the use of Carnicor, Venofer, and Sevelamer drugs. Carnicor is used as a source of L-carnitine, acting as antioxidant and neuroprotector. Venofer is used to reduce the deficit of iron...
May 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29340339/other-estimation-of-blood-losses-in-hemodialysis-and-formula-for-translating-liver-iron-concentration-from-iron-balance-calculation-based-on-iron-removal-by-phlebotomy
#18
https://www.readbyqxmd.com/read/29339674/relation-between-high-serum-hepcidin-25-level-and-subclinical-atherosclerosis-and-cardiovascular-mortality-in-hemodialysis-patients
#19
Özlem Yayar, Barış Eser, Harun Kılıç
OBJECTIVE: In hemodialysis (HD) patients, cardiovascular disease (CVD) is the major cause of mortality and morbidity. In atherosclerotic diseases, iron gets accumulated in the arterial wall. Hepcidin is an important hormone in iron metabolism. Furthermore, hepcidin is associated with atherosclerotic disease. Therefore, this study aims to investigate the relation of serum hepcidin-25 (SH-25) and sub-clinic atherosclerosis measured by carotid intima-media thickness (CIMT) and mortality in HD patients...
January 17, 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29227261/clinical-features-of-therapy-of-anemia-and-the-significance-of-its-fluctuation-in-the-development-of-anemia-in-dialysis-patients
#20
E Lapina, M Batiushin, V Terentiev, M Gasanov, A Gasanova
The aim of our study was to examine the features of therapy of anemia, and the influence of fluctuation in dose of antianemic drugs on hemoglobin levels in dialysis patients. The study included 100 patients with chronic kidney disease stage 5D receiving hemodialysis, mean age was 53,4±15,8 years. The clinical and anamnestic data were studied and laboratory tests were performed in all patients. The correlation between hemoglobin level and fluctuations in dose of antianemic drugs for 12 months: erythropoietin (R= -0,51, p=0,004) and iron (R= -0,46, p=0,01) was determined...
November 2017: Georgian Medical News
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