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https://www.readbyqxmd.com/read/29675257/treatment-of-addison-s-disease-during-pregnancy
#1
Diana Oliveira, Adriana Lages, Sandra Paiva, Francisco Carrilho
Addison's disease, or primary adrenocortical insufficiency, is a long-term, potentially severe, rare endocrine disorder. In pregnancy, it is even rarer. We report the case of a 30-year-old pregnant patient with Addison's disease, referred to Obstetrics-Endocrinology specialty consult at 14 weeks gestation. She had been to the emergency department of her local hospital various times during the first trimester presenting with a clinical scenario suggestive of glucocorticoid under-replacement (nausea, persistent vomiting and hypotension), but this was interpreted as normal pregnancy symptoms...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29669527/-i-didn-t-think-you-were-allowed-that-they-didn-t-mention-that-a-qualitative-study-exploring-women-s-perceptions-of-home-birth
#2
Jo Naylor Smith, Beck Taylor, Karen Shaw, Alistair Hewison, Sara Kenyon
BACKGROUND: Evidence suggests that home birth is as safe as hospital birth for low risk multiparous women, and is associated with reduced intervention rates and increased rates of normal birth. However the home birth rate in the UK is low, and few women choose this option. The aims of this study were to identify what influences multiparous women's choice of birth place, and to explore their views of home birth. METHODS: Five focus groups were conducted with multiparous women (n = 28) attending mother and baby groups in a city in the UK with a diverse multi-ethnic population...
April 18, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29669438/standardized-management-protocol-in-severe-postpartum-hemorrhage-a-single-center-study
#3
Giuseppe Colucci, Karin Helsing, Franziska Demarmels Biasiutti, Luigi Raio, Pirmin Schmid, Dimitrios A Tsakiris, Balthasar Eberle, Daniel Surbek, Bernhard Lämmle, Lorenzo Alberio
Severe postpartum hemorrhage (sPPH) is an obstetric emergency that needs prompt and effective therapy to reduce the risk of complications. In this study, women who developed sPPH (study cohort, n = 27) were treated according to a standardized management protocol prescribing sequential administration of uterotonic drugs, crystalloids, tranexamic acid, labile blood products, low-dose fibrinogen, and recombinant activated factor VII (rFVIIa). This group was compared to patients treated with different strategies during 2 preceding periods: an in-house guideline regulating the administration of rFVIIa (historical cohort 1, n = 20) and no specific guideline (historical cohort 2, n = 27)...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29668651/examining-trends-in-obstetric-quality-measures-for-monitoring-health-care-disparities
#4
Teresa Janevic, Natalia N Egorova, Jennifer Zeitlin, Amy Balbierz, Paul L Hebert, Elizabeth A Howell
BACKGROUND: Elective delivery (ED) before 39 weeks, low-risk cesarean delivery, and episiotomy are routinely reported obstetric quality measures and have been the focus of quality improvement initiatives over the past decade. OBJECTIVE: To estimate trends and differences in obstetric quality measures by race/ethnicity. RESEARCH DESIGN: We used 2008-2014 linked birth certificate-hospital discharge data from New York City to measure ED before 39 gestational weeks (ED <39), low-risk cesarean, and episiotomy by race/ethnicity...
April 17, 2018: Medical Care
https://www.readbyqxmd.com/read/29668367/which-patients-with-cervical-squamous-cell-carcinoma-might-benefit-from-neoadjuvant-chemotherapy
#5
Omar Mahmoud, Mark H Einstein
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
April 18, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29664956/you-pray-to-your-god-a-qualitative-analysis-of-challenges-in-the-provision-of-safe-timely-and-affordable-surgical-care-in-uganda
#6
Katherine Albutt, Rachel R Yorlets, Maria Punchak, Peter Kayima, Didacus B Namanya, Geoffrey A Anderson, Mark G Shrime
BACKGROUND: Five billion people lack access to safe, affordable, and timely surgical and anesthesia care. Significant challenges remain in the provision of surgical care in low-resource settings. Uganda is no exception. METHODS: From September to November 2016, we conducted a mixed-methods countrywide surgical capacity assessment at 17 randomly selected public hospitals in Uganda. Researchers conducted 35 semi-structured interviews with key stakeholders to understand factors related to the provision of surgical care...
2018: PloS One
https://www.readbyqxmd.com/read/29663461/the-legal-frameworks-that-govern-fetal-surgery-in-the-united-kingdom-european-union-and-the-united-states
#7
REVIEW
Kevin X Cao, Alice Booth, Sebastien Ourselin, Anna L David, Richard Ashcroft
The specialty of fetal surgery or fetal intervention is one of the most exciting emerging fields of modern medicine. It is made possible by decades of major developments in antenatal imaging, obstetric anaesthesia, fetal medicine, paediatric surgery and of course by the bold and novel practitioners willing to take new steps to advance the field. Beginning in the 1970s it has now reached a stage of maturity where there are several established in-utero procedures and countless clinical trials and studies to develop more...
April 16, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29662276/comparison-between-use-of-oral-misoprostol-versus-vaginal-misoprostol-for-induction-of-labour-at-term
#8
Prameela, Kavya D Sharma
Background and Objective: In modern obstetrics, around 30% of cases require induction of labour for various reasons. Misoprostol is gaining popularity as pharmacological inducing agent, though the route and dosage of administration are not standardised. The objective of the study is to compare the safety and efficacy of the two routes of misoprostol administration-oral (100 μg 4th hourly) and vaginal (25 μg 4th hourly), for induction of labour at term. Methods: In this randomised trial, 104 women having crossed the expected date of delivery without going into spontaneous labour and cases which had premature rupture of membranes <12 h were considered for labour induction and were divided into two equal groups...
April 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29661217/barriers-to-access-and-utilization-of-emergency-obstetric-care-at-health-facilities-in-sub-saharan-africa-a-systematic-review-protocol
#9
Ayele Geleto, Catherine Chojenta, Abdulbasit Mussa, Deborah Loxton
BACKGROUND: Nearly 15% of all pregnancies end in fatal perinatal obstetric complications including bleeding, infections, hypertension, obstructed labor, and complications of abortion. Between 1990 and 2015, an estimated 10.7 million women died due to obstetric complications. Almost all of these deaths (99%) happened in developing countries, and 66% of maternal deaths were attributed to sub-Saharan Africa. The majority of cases of maternal mortalities can be prevented through provision of evidence-based potentially life-saving signal functions of emergency obstetric care...
April 16, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29656684/nationwide-survey-of-severe-postpartum-haemorrhage-in-japan-an-exploratory-study-using-the-national-database-of-health-insurance-claims
#10
Mai Sato, Eiji Kondoh, Tomohide Iwao, Shusuke Hiragi, Kazuya Okamoto, Hiroshi Tamura, Haruta Mogami, Yoshitsugu Chigusa, Tomohiro Kuroda, Masaki Mandai, Ikuo Konishi, Genta Kato
AIM: The aim of this study was to investigate epidemiological and clinical aspects of severe postpartum haemorrhage (PPH) in Japan. METHODS: We used national health insurance claims from 2011 to 2014 provided by the Ministry of Health, Labour and Welfare. The data included randomly selected claims that covered 10% of all inpatients in October, a so-called sampling dataset (covering 1/120 inpatients per year). We extracted claims for transfused blood, and further narrowed down the claims by names of diseases linked to PPH...
April 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29644153/acute-fatty-liver-of-pregnancy-a-thorough-examination-of-a-harmful-obstetrical-syndrome-and-its-counterparts
#11
Joshua Ronen, Shahzeb Shaheen, David Steinberg, Kevin R Justus
Diagnosed in one of every 20,000 deliveries, acute fatty liver of pregnancy (AFLP) was considered to be a deadly disease for many years. However, advancements in the clinical and surgical management of pregnant mothers have lead to a drastic decrease in maternal morbidity and mortality. The corresponding case recounts a 23-year-old gravida 2 para 1 (G2P1) at 38 weeks gestational age (GA) with no relevant past medical or family medical history that presented to the emergency department (ED) with a five-day history of nausea, protracted vomiting, hypertension, and new-onset headache...
February 6, 2018: Curēus
https://www.readbyqxmd.com/read/29628965/improving-and-expanding-the-quality-of-emergency-obstetric-and-newborn-care-services-in-rural-areas-of-cambodia
#12
Saurabh R Shrivastava, Prateek S Shrivastava, Jegadeesh Ramasamy
No abstract text is available yet for this article.
March 2018: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29627348/the-acute-treatment-of-methemoglobinemia-in-pregnancy
#13
Nels Grauman Neander, Carly A Loner, Jason M Rotoli
BACKGROUND: Methemoglobinemia can be a potentially lethal condition due to the hypoxic stress placed on the body. In pregnancy, the deleterious effects can be even more catastrophic. The benefits of treatment in all patients, especially in those who are pregnant, must outweigh the inherent risks of the therapies used to treat methemoglobinemia. CASE REPORT: We present a case of a 26-year-old Hispanic pregnant female at 30 weeks gestation presenting to the emergency department for chest pain, hypoxia, and cyanosis...
April 4, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29626722/a-qualitative-study-of-nulliparous-women-s-decision-making-on-mode-of-delivery-under-china-s-two-child-policy
#14
Chunyi Gu, Xinli Zhu, Yan Ding, Setterberg Simone, Xiaojiao Wang, Hua Tao, Yu Zhang
OBJECTIVE: To explore nulliparous women's perceptions of decision making regarding mode of delivery under China's two-child policy. DESIGN: Qualitative descriptive design with in-depth semi-structured interviews. SETTING: Postnatal wards at a tertiary specialized women's hospital in Shanghai, China. PARTICIPANTS: 21 nulliparous women 2-3 days postpartum were purposively sampled until data saturation. METHODS: In-depth semi-structured interviews were conducted between October 8th, 2015 and January 31st, 2016...
March 20, 2018: Midwifery
https://www.readbyqxmd.com/read/29621911/incidence-and-natural-history-of-preeclampsia-eclampsia-at-the-university-maternity-of-antananarivo-madagascar-high-prevalence-of-the-early-onset-condition
#15
Andriamanetsiarivo Tanjona Ratsiatosika, Eric Razafimanantsoa, Valéry Bruno Andriantoky, Noël Ravoavison, Rakotovao Andrianampanalinarivo Hery, Malik Boukerrou, Silvia Iacobelli, Pierre-Yves Robillard
OBJECTIVES: To investigate the incidence of early - (delivery < 34 weeks) (EOP) versus late-onset (delivery ≥ 34 weeks) (LOP) in Madagascar. STUDY DESIGN: Eight months observational study of all preeclamptic/eclamptic women delivering at the maternity of the University Hospital of Befelatanana, Antananarivo, Madagascar. Sociodemographical and obstetrical risk factors are analysed. RESULTS: Over the study period, we found 142 combined preeclampsia/eclampsia among 4316 births (incidence 3...
April 5, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29616653/accessibility-of-cesarean-deliveries-in-benin
#16
V Mongbo, J Saïzonou, G Sopoh, C Sossa-Jérôme, E M Ouendo, I Godin
To be used effectively, emergency obstetric and neonatal care must be available and accessible. This study sought to measure the accessibility of cesarean deliveries in Benin. Cross-sectional study of randomly selected women in each of the 12 obstetrics departments in Benin. Geographical accessibility was measured by estimating the distance between the parturientes residence and the hospital. Financial accessibility was the average direct cost of the cesarean delivery -the sum of medical and non-medical costs...
February 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29608700/trophoblast-retrieval-and-isolation-from-the-cervix-origins-of-cervical-trophoblasts-and-their-potential-value-for-risk-assessment-of-ongoing-pregnancies
#17
Gerit Moser, Sascha Drewlo, Berthold Huppertz, D Randall Armant
BACKGROUND: Early during human development, the trophoblast lineage differentiates to commence placentation. Where the placenta contacts the uterine decidua, extravillous trophoblast (EVT) cells differentiate and invade maternal tissues. EVT cells, identified by expression of HLA-G, invade into uterine blood vessels (endovascular EVT), as well as glands (endoglandular EVT), and open such luminal structures towards the intervillous space of the placenta. Endoglandular invasion diverts the contents of uterine glands to the intervillous space, while glands near the margin of the placenta that also contain endoglandular EVT cells open into the reproductive tract...
March 28, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29607328/maternal-fetal-and-neonatal-outcomes-in-pregnant-dengue-patients-in-mexico
#18
Carlos Machain-Williams, Eric Raga, Carlos M Baak-Baak, Sungmin Kiem, Bradley J Blitvich, Celso Ramos
To increase our understanding of the consequences of dengue virus infection during pregnancy, a retrospective analysis was performed on the medical records of all completed pregnancies (live births and pregnancy losses) at nine public hospitals in the Gulf of Mexico from January to October 2013. Eighty-two patients developed clinical, laboratory-confirmed dengue virus infections while pregnant. Of these, 54 (65.9%) patients were diagnosed with dengue without warning signs, 15 (18.3%) patients were diagnosed with dengue with warning signs, and 13 (15...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29602171/appendicectomy-during-pregnancy-and-the-risk-of-preterm-birth-a-population-data-linkage-study
#19
Ibinabo Ibiebele, Margaret Schnitzler, Tanya Nippita, Jane B Ford
BACKGROUND: Suspected appendicitis is a common non-obstetric indication for emergency abdominal surgery during pregnancy. AIMS: Assess the risk of preterm birth and other maternal and neonatal adverse birth outcomes following appendicectomy during pregnancy. MATERIALS AND METHODS: Population-based data linkage study of women with singleton births in New South Wales, Australia, 2002-2014. Pregnancies with appendicitis and appendicectomy were compared to pregnancies without appendicitis...
March 30, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29596431/measuring-the-preparedness-of-health-facilities-to-deliver-emergency-obstetric-care-in-a-south-african-district
#20
Siphiwe Bridget Pearl Thwala, Duane Blaauw, Freddie Ssengooba
BACKGROUND: Improving the delivery of emergency obstetric care (EmNOC) remains critical in addressing direct causes of maternal mortality. United Nations (UN) agencies have promoted standard methods for evaluating the availability of EmNOC facilities although modifications have been proposed by others. This study presents an assessment of the preparedness of public health facilities to provide EmNOC using these methods in one South African district with a persistently high maternal mortality ratio...
2018: PloS One
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