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https://www.readbyqxmd.com/read/28231591/predictive-success-factors-in-selective-upper-airway-stimulation
#1
Clemens Heiser, Benedikt Hofauer
Obstructive sleep apnea is one of the most common diseases in Western industrialized countries. A variety of conservative and surgical treatment options are available for its treatment. In recent years, selective upper airway stimulation (sUAS) has been shown to be effective and safe. Different biomarkers have been investigated as predictive clinical success factors in a number of clinical trials. Age does not matter in sUAS, as compared to its predictive role in other therapies. Weight seems to play a limited role, depending on drug-induced sleep endoscopy to rule out a complete concentric collapse with an increased body mass index...
February 24, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28230600/nasal-valve-collapse-our-treatment-protocol
#2
Giulia Amodeo, Domenico Scopelliti
The nasal valve area is the functional area that allows airflow regulation. It could be divided in an internal area and an external one, basing on the anatomical landmarks. Many conditions can damage these areas with a consequently nasal obstruction, more often in particular extended rhinoplasty and sequels of facial trauma. To restore this area many techniques were advocated during the last decades.In this article the authors investigate on valve areas deficiency in sequel of rhinoplasty proposing a structural approach through alar batten grafts to correct internal-external nasal valves collapse...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28230141/collapse-of-aztec-society-linked-to-catastrophic-salmonella-outbreak
#3
Ewen Callaway
No abstract text is available yet for this article.
February 16, 2017: Nature
https://www.readbyqxmd.com/read/28229067/the-effect-of-world-trade-center-exposure-on-the-timing-of-diagnoses-of-obstructive-airway-disease-chronic-rhinosinusitis-and-gastroesophageal-reflux-disease
#4
Xiaoxue Liu, Jennifer Yip, Rachel Zeig-Owens, Jessica Weakley, Mayris P Webber, Theresa M Schwartz, David J Prezant, Michael D Weiden, Charles B Hall
OBJECTIVES: In a cohort of rescue/recovery workers exposed to the dust that resulted from the collapse of the World Trade Center (WTC), we assessed how a diagnosis of obstructive airways disease (OAD) affected the likelihood of a subsequent diagnosis of chronic rhinosinusitis (CRS) or gastroesophageal reflux disease (GERD). We also assessed whether OAD acted as a mediator of the association between exposure to the WTC rescue/recovery effort and CRS and GERD diagnoses. METHODS: In this prospective cohort study, we analyzed Fire Department of the City of New York physician diagnoses of OAD, CRS, and GERD that were first documented between September 11, 2001, and September 10, 2011, among 8,968 WTC-exposed firefighters...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28228916/species-diversity-and-abundance-of-marine-crabs-portunidae-decapoda-from-a-collapsible-crab-trap-fishery-at-kung-krabaen-bay-chanthaburi-province-thailand
#5
Chutapa Kunsook, Pongchai Dumrongrojwatthana
The diversity and abundance of marine crabs from a collapsible crab trap fishery at Kung Krabaen Bay, Gulf of Thailand, were observed from August 2012 to June 2013 using 10 sampling stations. The results showed that there were seven families, 11 genera and 17 species (two anomuran and 15 brachyuran crabs). The two anomuran species were Clibanarius virescens (1,710 individuals) and Clibanarius infraspinatus (558 individuals). For brachyuran crabs, Portunidae was the most common family, including 10 species. The dominant species of brachyuran crabs included Thalamita crenata (897 individuals), Portunus pelagicus (806 individuals), Charybdis affinis (344 individuals), Scylla sp...
January 2017: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/28228834/anti-collapsing-response-mediating-protein-5-antibody-positive-paraneoplastic-perioptic-neuritis-without-typical-neurological-symptoms
#6
Nozomi Igarashi, Hiromasa Sawamura, Toshikatsu Kaburaki, Makoto Aihara
A 68-year-old male presented with blurred vision in both eyes. Ophthalmoscopy revealed bilateral prominent disc swelling and vitritis. No systematic neurological symptoms were observed. Magnetic resonance imaging revealed bilateral meningeal enhancement of the optic nerve. Small cell carcinoma was found, and antibodies against collapsing response-mediating protein-5 (CRMP-5) were detected in the serum. Ophthalmological manifestations disappeared during a decrease in tumour size with treatment for the malignancy...
February 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28228526/trimethylamine-n-oxide-stabilizes-proteins-via-a-distinct-mechanism-compared-with-betaine-and-glycine
#7
Yi-Ting Liao, Anthony C Manson, Michael R DeLyser, William G Noid, Paul S Cremer
We report experimental and computational studies investigating the effects of three osmolytes, trimethylamine N-oxide (TMAO), betaine, and glycine, on the hydrophobic collapse of an elastin-like polypeptide (ELP). All three osmolytes stabilize collapsed conformations of the ELP and reduce the lower critical solution temperature (LSCT) linearly with osmolyte concentration. As expected from conventional preferential solvation arguments, betaine and glycine both increase the surface tension at the air-water interface...
February 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28227085/an-object-oriented-model-of-the-cardiopulmonary-system-with-emphasis-on-the-gravity-effect
#8
Chuong Ngo, Silvia Briones Herranz, Berno Misgeld, Thomas Vollmer, Steffen Leonhardt, Chuong Ngo, Silvia Briones Herranz, Berno Misgeld, Thomas Vollmer, Steffen Leonhardt, Thomas Vollmer, Steffen Leonhardt, Chuong Ngo, Berno Misgeld
We introduce a novel comprehensive model of the cardiopulmonary system with emphasis on perfusion and ventilation distribution along the vertical thorax axis under the gravity effect. By using an object-oriented environment, the complex physiological system can be represented by a network of electrical, lumped-element compartments. The lungs are divided into three zones: upper, middle, and lower zone. Blood flow increases with the distance from the apex to the base of the lungs. The upper zone is characterized by a complete collapse of the pulmonary capillary vasculature; thus, there is no flow in this zone...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226934/self-folding-hydrogel-bilayer-for-enhanced-drug-loading-encapsulation-and-transport
#9
Hen-Wei Huang, Andrew J Petruska, Mahmut Selman Sakar, Maria Skoura, Franziska Ullrich, Qi Zhangm, Salvador Pane, Bradley J Nelson, Hen-Wei Huang, Andrew J Petruska, Mahmut Selman Sakar, Maria Skoura, Franziska Ullrich, Qi Zhangm, Salvador Pane, Bradley J Nelson, Hen-Wei Huang, Franziska Ullrich, Bradley J Nelson, Maria Skoura, Mahmut Selman Sakar, Salvador Pane, Andrew J Petruska
Hydrogel-based robotic microdevices are currently investigated for minimally invasive medical procedures. Hydrogels are especially suited to targeted drug delivery applications as they are able to carry several times more drug solution than its dry weight. A major drawback of these system is that drug release takes place before reaching the targeted area in the body. We introduce a strategy based on a self-folding bilayer to prevent release during transportation without hindering the drug loading efficiency of the hydrogel...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225822/a-reconfiguration-of-the-sex-trade-how-social-and-structural-changes-in-eastern-zimbabwe-left-women-involved-in-sex-work-and-transactional-sex-more-vulnerable
#10
Jocelyn Elmes, Morten Skovdal, Kundai Nhongo, Helen Ward, Catherine Campbell, Timothy B Hallett, Constance Nyamukapa, Peter J White, Simon Gregson
Understanding the dynamic nature of sex work is important for explaining the course of HIV epidemics. While health and development interventions targeting sex workers may alter the dynamics of the sex trade in particular localities, little has been done to explore how large-scale social and structural changes, such as economic recessions-outside of the bounds of organizational intervention-may reconfigure social norms and attitudes with regards to sex work. Zimbabwe's economic collapse in 2009, following a period (2000-2009) of economic decline, within a declining HIV epidemic, provides a unique opportunity to study community perceptions of the impact of socio-economic upheaval on the sex trade...
2017: PloS One
https://www.readbyqxmd.com/read/28225593/programmed-self-assembly-of-hierarchical-nanostructures-through-protein-nanoparticle-co-engineering
#11
Rubul Mout, Gulen Yesilbag Tonga, Li-Sheng Wang, Moumita Ray, Trinava Roy, Vincent M Rotello
Hierarchical organization of macromolecules through self-assembly is a prominent feature in biological systems. Synthetic fabrication of such structures provides materials with emergent functions. Here we report the fabrication of self-assembled superstructures through co-engineering of recombinant proteins and nanoparticles. These structures feature a highly-sophisticated level of multi-layered hierarchical organization of the components: individual proteins and nanoparticles co-assemble to form discrete assemblies that collapse to form granules, which then further self-organize to generate superstructures of hundreds of nanometer size...
February 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28225580/real-time-multislice-mri-during-continuous-positive-airway-pressure-reveals-upper-airway-response-to-pressure-change
#12
Weiyi Chen, Emily Gillett, Michael C K Khoo, Sally L Davidson Ward, Krishna S Nayak
PURPOSE: To determine if a real-time magnetic resonance imaging (RT-MRI) method during continuous positive airway pressure (CPAP) can be used to measure neuromuscular reflex and/or passive collapsibility of the upper airway in individual obstructive sleep apnea (OSA) subjects. MATERIALS AND METHODS: We conducted experiments on four adolescents with OSA and three healthy controls, during natural sleep and during wakefulness. Data were acquired on a clinical 3T scanner using simultaneous multislice (SMS) RT-MRI during CPAP...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28225537/laryngeal-sensitivity-testing-in-youth-with-exercise-inducible-laryngeal-obstruction
#13
Irena Hočevar-Boltežar, Uroš Krivec, Maja Šereg-Bahar
Exercise-inducible laryngeal obstruction (EILO) has been recognized as a not rare respiratory problem in youth practicing sports. The aim of the study was to test the mechanosensitivity of the larynx, and to identify the factors affecting it in a group of youth with proven EILO. Laryngeal sensory testing was performed in 54 adolescents and young adults with EILO. Laryngeal mucosal alterations were assessed according to the Reflux Finding Score (RFS). The data concerning diseases possibly affecting the upper airway, findings of previously performed flexible videolaryngoscopy during exercise, and RFS score were compared between the participants with laryngeal hyposensitivity and those with normal sensitivity...
February 20, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28224302/retinal-cavernous-haemangioma-treated-by-proton-beam-therapy
#14
Amir Mahdjoubi, Rémi Dendale, Livia Lumbroso-Le Rouic, Laurence Desjardins, Nathalie Cassoux
As one of intraocular tumours, retinal cavernous haemangioma is a benign vascular lesion that is mostly unilateral. Very few cases about cavernous haemangioma treatment are reported, and there is currently no consensus on the most effective treatment. This clinical case reports on a 40-year-old male, presenting a peripheral retinal cavernous haemangioma, complicated with a repetitive vitreous haemorrhage causing bad vision. Several therapeutic methods were unsuccessfully attempted to stop haemorrhagic recurrences...
February 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28224280/predictors-of-success-in-combination-of-tongue-base-resection-and-lateral-pharyngoplasty-for-obstructive-sleep-apnea
#15
Chi Sang Hwang, Jin Won Kim, Sang Chul Park, Hyo Jin Chung, Chang-Hoon Kim, Joo-Heon Yoon, Hyung-Ju Cho
The base of the tongue has been recognized as a significant site of obstruction in patients with obstructive sleep apnea (OSA). Our aim was to determine the independent predictors of surgical success in tongue base resection combined with lateral pharyngoplasty for OSA. Thirty-one OSA patients who underwent endoscopie-guided coblator or transoral robotic tongue base resection in combination with lateral pharyngoplasty for the treatment of retroglossal obstruction between March 2012 and December 2015 were enrolled in this study...
February 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28224174/spectroscopic-polarographic-and-microcalorimetric-studies-on-mitochondrial-dysfunction-induced-by-ethanol
#16
Long Ma, Jia-Xin Dong, Can Wu, Xue-Yi Li, Jing Chen, Hong Zhang, Yi Liu
Liver mitochondria are involved in several important life processes; mitochondrial dysfunction and disorders are implicated in several human diseases. Alcohol permeates all tissues of the body and exerts some intrinsic hepatotoxicity. In this work, our results demonstrated that ethanol caused a series of mitochondria permeability transition pore (MPTP) opening factors such as mitochondrial swelling, increased permeability of H(+) and K(+), collapsed membrane potential, and increased membrane fluidity. Furthermore, mitochondrial ultrastructure alternation observed clearly by transmission electron microscopy and the release of Cytochrome c could explain the MPTP opening from another aspect...
February 21, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28224017/the-effect-of-carbamic-acid-1-2-3-thiadiazole-4-ylcarbonyl-hexyl-ester-on-peronophythora-litchii-infection-quality-and-physiology-of-postharvest-litchi-fruits
#17
Hai Liu, Guoxing Jing, Yueming Jiang, Fuying Luo, Zaifeng Li
BACKGROUND: Litchi (Litchi chinensis Sonn.) is a subtropical fruit with attractive characteristic of white to creamy semitranslucent flesh and red color in pericap, but it was easily subjected to the infection of Peronophythora litchii and lost its market values. Experiments were conducted to understand the effect of [Carbamic acid, (1,2,3-thiadiazole-4-ylcarbonyl)-hexyl ester, CTE] on the growth of P. litchi and quality properties in litchi fruits during postharvest storage. RESULTS: In vitro experiments, CTE with minimum inhibitory concentration (MIC, 5 mg/L) and minimum fungicidal concentration (MFC, 10 mg/L) were against the growth of P...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28223727/remote-ischemic-perconditioning-prevents-liver-transplantation-induced-ischemia-reperfusion-injury-in-rats-role-of-ros-rns-and-enos
#18
Ning He, Jun-Jun Jia, Jian-Hui Li, Yan-Fei Zhou, Bing-Yi Lin, Yi-Fan Peng, Jun-Jie Chen, Tian-Chi Chen, Rong-Liang Tong, Li Jiang, Hai-Yang Xie, Lin Zhou, Shu-Sen Zheng
AIM: To investigate the underlying mechanisms of the protective role of remote ischemic perconditioning (RIPerC) in rat liver transplantation. METHODS: Sprague-Dawley rats were subjected to sham, orthotopic liver transplantation (OLT), ischemic postconditioning (IPostC) or RIPerC. After 3 h reperfusion, blood samples were taken for measurement of alanine aminotransferase, aspartate aminotransferase, creatinine (Cr) and creatinine kinase-myocardial band (CK-MB). The liver lobes were harvested for the following measurements: reactive oxygen species (ROS), H2O2, mitochondrial membrane potential (ΔΨm) and total nitric oxide (NO)...
February 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28221708/improved-management-of-small-pelagic-fisheries-through-seasonal-climate-prediction
#19
Désirée Tommasi, Charles A Stock, Kathleen Pegion, Gabriel A Vecchi, Richard D Methot, Michael A Alexander, David M Checkley
Populations of small pelagic fish are strongly influenced by climate. The inability of managers to anticipate environment-driven fluctuations in stock productivity or distribution can lead to overfishing and stock collapses, inflexible management regulations inducing shifts in the functional response to human predators, lost opportunities to harvest populations, bankruptcies in the fishing industry, and loss of resilience in the human food supply. Recent advances in dynamical global climate prediction systems allow for sea surface temperature (SST) anomaly predictions at a seasonal scale over many shelf ecosystems...
October 12, 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28221026/nanomechanics-of-ph-responsive-drug-loaded-bi-layered-polymer-grafts
#20
Prathima Chandra Nalam, Hyun-Su Lee, Nupur Bhatt, Robert W Carpick, David M Eckmann, Russell J Composto
Stimuli-responsive polymer films play an important role in the development of smart antibacterial coatings. In this study, we consider complementary architectures of polyelectrolyte films including a thin chitosan layer (CH), poly (acrylic acid) (PAA) brushes and a bilayer structure of CH grafted to PAA brushes (CH/PAA) as possible candidates for targeted drug delivery platforms. Atomic force microscopy (AFM) was employed to study the structure-mechanical property relationship for these mono- and bi- layered polymer grafts at pH 7...
February 21, 2017: ACS Applied Materials & Interfaces
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