keyword
MENU ▼
Read by QxMD icon Read
search

Collapse

keyword
https://www.readbyqxmd.com/read/28641116/mechanisms-for-selective-single-cell-reactivation-during-offline-sharp-wave-ripples-and-their-distortion-by-fast-ripples
#1
Manuel Valero, Robert G Averkin, Ivan Fernandez-Lamo, Juan Aguilar, Diego Lopez-Pigozzi, Jorge R Brotons-Mas, Elena Cid, Gabor Tamas, Liset Menendez de la Prida
Memory traces are reactivated selectively during sharp-wave ripples. The mechanisms of selective reactivation, and how degraded reactivation affects memory, are poorly understood. We evaluated hippocampal single-cell activity during physiological and pathological sharp-wave ripples using juxtacellular and intracellular recordings in normal and epileptic rats with different memory abilities. CA1 pyramidal cells participate selectively during physiological events but fired together during epileptic fast ripples...
June 21, 2017: Neuron
https://www.readbyqxmd.com/read/28637001/a-novel-method-to-generate-salmonella-typhi-ty21a-ghosts-exploiting-the-%C3%AE-phage-holin-endolysin-system
#2
Gayeon Won, Boram Kim, John Hwa Lee
Human typhoid fever caused by Salmonella Typhi still poses a severe global disease burden in developing countries despite the availability of commercial vaccines. In this study, we constructed a non-living S. Typhi Ty21a vaccine candidate by employing a lambda (λ) phage-derived holin-endolysin system to efficiently construct bacterial ghosts. The lysis plasmid pJHL464 harbors an R lysis cassette that is stringently regulated by dual promoters containing cI857/λPR and ParaBAD/araC components. The plasmid was introduced into an asd gene-deleted S...
June 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28636751/using-experimentation-to-understand-the-10-year-snowshoe-hare-cycle-in-the-boreal-forest-of-north-america
#3
C J Krebs, R Boonstra, S Boutin
Population cycles have long fascinated ecologists from the time of Charles Elton in the 1920s. The discovery of large population fluctuations in undisturbed ecosystems challenged the idea that pristine nature was in a state of balance. The 10-year cycle of snowshoe hares (Lepus americanus Erxleben) across the boreal forests of Canada and Alaska is a classic cycle, recognized by fur traders for more than 300 years. Since the 1930s ecologists have investigated the mechanisms that might cause these cycles. Proposed causal mechanisms have varied from sunspots to food supplies, parasites, diseases, predation, and social behaviour...
June 21, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28635953/rare-rnf213-variants-in-the-c-terminal-region-encompassing-the-ring-finger-domain-are-associated-with-moyamoya-angiopathy-in-caucasians
#4
Stéphanie Guey, Markus Kraemer, Dominique Hervé, Thomas Ludwig, Manoëlle Kossorotoff, Françoise Bergametti, Jan Claudius Schwitalla, Simone Choi, Lucile Broseus, Isabelle Callebaut, Emmanuelle Genin, Elisabeth Tournier-Lasserve
Moyamoya angiopathy (MMA) is a cerebral angiopathy affecting the terminal part of internal carotid arteries. Its prevalence is 10 times higher in Japan and Korea than in Europe. In East Asian countries, moyamoya is strongly associated to the R4810K variant in the RNF213 gene that encodes for a protein containing a RING-finger and two AAA+ domains. This variant has never been detected in Caucasian MMA patients, but several rare RNF213 variants have been reported in Caucasian cases. Using a collapsing test based on exome data from 68 European MMA probands and 573 ethnically matched controls, we showed a significant association between rare missense RNF213 variants and MMA in European patients (odds ratio (OR)=2...
June 21, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28635185/antipulverization-electrode-based-on-low-carbon-triple-shelled-superstructures-for-lithium-ion-batteries
#5
Lianhai Zu, Qingmei Su, Feng Zhu, Bingjie Chen, Huanhuan Lu, Chengxin Peng, Ting He, Gaohui Du, Pengfei He, Kai Chen, Shihe Yang, Jinhu Yang, Huisheng Peng
The realization of antipulverization electrode structures, especially using low-carbon-content anode materials, is crucial for developing high-energy and long-life lithium-ion batteries (LIBs); however, this technology remains challenging. This study shows that SnO2 triple-shelled hollow superstructures (TSHSs) with a low carbon content (4.83%) constructed by layer-by-layer assembly of various nanostructure units can withstand a huge volume expansion of ≈231.8% and deliver a high reversible capacity of 1099 mAh g(-1) even after 1450 cycles...
June 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28634780/echocardiographic-inferior-vena-cava-measurement-as-an-alternative-to-central-venous-pressure-measurement-in-neonates
#6
Muzamil Mustafa Mugloo, Seema Malik, Rubeena Akhtar
OBJECTIVES: To evaluate the correlation between echocardiographic inferior vena cava (IVC) measurements and central venous pressure (CVP) in neonates. Also, to evaluate the correlation between IVC measurements and gestational age (GA) and body weight (BW). METHODS: This cross sectional analytical study was conducted from June 2014 through June 2016 in a level III NICU. All neonates requiring intensive hemodynamic monitoring and having umbilical venous catheter (UVC) in place for clinical indications were enrolled in the study...
June 21, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28634561/custom-made-alumina-ceramic-total-talar-prosthesis-for-idiopathic-aseptic-necrosis-of-the-talus-report-of-two-cases
#7
Ichiro Tonogai, Daisuke Hamada, Yuhei Yamasaki, Keizo Wada, Tomoya Takasago, Takahiko Tsutsui, Tomohiro Goto, Koichi Sairyo
Two women aged 65 years and 78 years presented to our center with idiopathic necrosis of the talus. In both cases, imaging examinations showed collapse and sclerotic changes of the talar body caused by the necrosis. Both women underwent resection and placement of a third-generation custom-made alumina ceramic total talar prosthesis. Immobilization of the ankle in a short-leg cast for 3 weeks was followed by early rehabilitation. One year and 6 months after surgery, both women were able to walk without pain...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28634400/chronic-treatment-with-cisplatin-induces-chemoresistance-through-the-tip60-mediated-fanconi-anemia-and-homologous-recombination-repair-pathways
#8
Wen-Pin Su, Yen-Chih Ho, Cheng-Kuei Wu, Sen-Huei Hsu, Jia-Lin Shiu, Jheng-Cheng Huang, Song-Bin Chang, Wen-Tai Chiu, Jan-Jong Hung, Tsung-Lin Liu, Wei-Sheng Wu, Pei-Yu Wu, Wu-Chou Su, Jang-Yang Chang, Hungjiun Liaw
The Fanconi anemia pathway in coordination with homologous recombination is essential to repair interstrand crosslinks (ICLs) caused by cisplatin. TIP60 belongs to the MYST family of acetyltransferases and is involved in DNA repair and regulation of gene transcription. Although the physical interaction between the TIP60 and FANCD2 proteins has been identified that is critical for ICL repair, it is still elusive whether TIP60 regulates the expression of FA and HR genes. In this study, we found that the chemoresistant nasopharyngeal carcinoma cells, derived from chronic treatment of cisplatin, show elevated expression of TIP60...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634380/late-onset-circulatory-collapse-and-continuous-positive-airway-pressure-are-useful-predictors-of-treatment-requiring-retinopathy-of-prematurity-a-9-year-retrospective-analysis
#9
Mitsuru Arima, Shoko Tsukamoto, Kohta Fujiwara, Miwa Murayama, Kanako Fujikawa, Koh-Hei Sonoda
Visual loss caused by retinopathy of prematurity (ROP) will be prevented if treatment-requiring ROP (TR-ROP) can be predicted. In this retrospective study including 418 infants with ≤32 weeks of gestational age (GA) and/or ≤1500 grams of birthweight, we attempted to identify useful predictors. We also examined the efficiency of significant predictors compared with existing predictive models, ROPScore and CHOP model. Multivariable logistic regression analyses supported the following factors were useful for predicting TR-ROP from all infants and infants with any ROP: GA (odds ratio [OR], 0...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28633849/effects-of-bovine-serum-albumin-on-a-single-cavitation-bubble
#10
Shuibao Qi, Badreddine Assouar, Weizhong Chen
The dynamics and sonoluminescence (SL) of a single cavitation bubble in bovine serum albumin (BSA) aqueous solutions have been experimentally and theoretically investigated. A phase-locked integral imaging has been used to record the bubble pulsation evolutions. The results show that, under the optimum driving condition, the endurable driving pressure, maximum radius, radius compression ratio and SL intensity of the cavitation bubble increase correspondingly with the increase of BSA concentrations within the critical micelle concentration, which indicates that the addition of BSA increases the power capability of the cavitation bubble...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28633776/bioabsorbable-calcaneo-stop-implant-for-the-treatment-of-flexible-flatfoot-a-retrospective-cohort-study-at-a-minimum-follow-up-of-4%C3%A2-years
#11
Sandro Giannini, Matteo Cadossi, Antonio Mazzotti, Valentina Persiani, Giuseppe Tedesco, Matteo Romagnoli, Cesare Faldini
Arthroereisis of the subtalar joint is a common surgical technique in Europe for the management of flexible flatfoot in the pediatric population. In most cases, it is performed using a calcaneo-stop metallic screw. Despite the good clinical results, screw removal is always advised after 2 to 3 years. The use of a bioabsorbable screw might overcome the need for a second operation to remove a nonabsorbable device. We report the results of a biodegradable calcaneo-stop screw at a minimum of 4 years of follow-up...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633724/change-in-end-expiratory-lung-volume-during-sleep-in-patients-at-risk-for-obstructive-sleep-apnea
#12
Patrick Koo, Eric J Gartman, Jigme M Sethi, Eyad Kawar, F Dennis McCool
STUDY OBJECTIVES: As lung volume decreases radial traction on the upper airway is reduced, making it more collapsible. The purpose of this study was to measure change in end-expiratory lung volume (EELV) following sleep onset and to evaluate the relationship between change in EELV and sleep-disordered breathing. METHODS: Twenty subjects underwent overnight polysomnography, of whom 14 (70%) had obstructive sleep apnea (OSA). Change in EELV was measured throughout the night using magnetometry...
June 16, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28632782/microbial-inhibitors-of-the-fungus-pseudogymnoascus-destructans-the-causal-agent-of-white-nose-syndrome-in-bats
#13
Emma W Micalizzi, Jonathan N Mack, George P White, Tyler J Avis, Myron L Smith
Pseudogymnoascus destructans, the fungus that causes white-nose syndrome in hibernating bats, has spread across eastern North America over the past decade and decimated bat populations. The saprotrophic growth of P. destructans may help to perpetuate the white-nose syndrome epidemic, and recent model predictions suggest that sufficiently reducing the environmental growth of P. destructans could help mitigate or prevent white-nose syndrome-associated bat colony collapse. In this study, we screened 301 microbes from diverse environmental samples for their ability to inhibit the growth of P...
2017: PloS One
https://www.readbyqxmd.com/read/28632583/incremental-balloon-deflation-following-complete-resuscitative-endovascular-balloon-occlusion-of-the-aorta-results-in-steep-inflection-of-flow-and-rapid-reperfusion-in-a-large-animal-model-of-hemorrhagic-shock
#14
Anders J Davidson, Rachel M Russo, Sarah-Ashley E Ferencz, Jeremy W Cannon, Todd E Rasmussen, Lucas P Neff, M Austin Johnson, Timothy K Williams
INTRODUCTION: To avoid potential cardiovascular collapse after resuscitative endovascular balloon occlusion of the aorta (REBOA), current guidelines recommend methodically deflating the balloon for 5 minutes to gradually reperfuse distal tissue beds. However, anecdotal evidence suggests that this approach may still result in unpredictable aortic flow rates and hemodynamic instability. We sought to characterize aortic flow dynamics following REBOA as the balloon is deflated in accordance with current practice guidelines...
July 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28632566/gottron-papules-show-histopathologic-features-of-localized-lymphedema
#15
Angel Fernandez-Flores, David S Cassarino
Although Gottron papules are a relevant feature of dermatomyositis, they are reported in very few papers in the literature, and the largest series on the subject includes 11 cases. We intend to study the main histopathologic features of Gottron papules in a series of 12 biopsies. We evaluated hematoxylin-eosin stains on all cases. We also performed histochemical stains to evaluate the dermal deposition of mucin. Finally, we studied the CD123 cell population in the inflammatory infiltrate by immunohistochemistry...
July 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28631616/on-the-dynamics-of-perching-manoeuvres-with-low-aspect-ratio-planforms
#16
J N Fernando, D E Rival
The dynamics of a simple perching manoeuvre are investigated using circular and aspect-ratio-two elliptical flat plates, as abstractions of low-aspect-ratio planforms observed in highly-manoeuvrable birds. The perching kinematic investigated in this study involves a pitch-up motion from an angle of attack of [Formula: see text] to [Formula: see text], while simultaneously decelerating. This motion is defined by the shape change number, [Formula: see text], which acts as a measure of the relative contributions of added-mass and circulatory effects...
June 20, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28631580/bulletproof-heart-gunshot-wound-to-the-ventricular-septum-without-pericardial-effusion-or-hemodynamic-collapse
#17
Lora Alkhawam, Stephen J Greene
No abstract text is available yet for this article.
June 20, 2017: CJEM
https://www.readbyqxmd.com/read/28631108/reproduction-number-and-asymptotic-stability-for-the-dynamics-of-a-honey-bee-colony-with-continuous-age-structure
#18
M I Betti, L M Wahl, M Zamir
A system of partial differential equations is derived as a model for the dynamics of a honey bee colony with a continuous age distribution, and the system is then extended to include the effects of a simplified infectious disease. In the disease-free case, we analytically derive the equilibrium age distribution within the colony and propose a novel approach for determining the global asymptotic stability of a reduced model. Furthermore, we present a method for determining the basic reproduction number [Formula: see text] of the infection; the method can be applied to other age-structured disease models with interacting susceptible classes...
June 19, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28629917/personalized-management-approach-for-obstructive-sleep-apnea
#19
REVIEW
Jayne C Carberry, Jason Amatoury, Danny J Eckert
Obstructive sleep apnea (OSA) is a heterogeneous disorder. If left untreated, OSA has major health, safety and economic consequences. In addition to varying levels of impairment in pharyngeal anatomy (narrow/collapsible airway), non-anatomical 'phenotypic traits' are also important contributors to OSA for most patients. However, the majority of existing therapies only target the anatomical cause (e.g. continuous positive airway pressure [CPAP], oral appliances, weight loss, positional therapy, and upper airway surgery)...
June 16, 2017: Chest
https://www.readbyqxmd.com/read/28628645/effect-of-horizontal-rectus-surgery-for-the-correction-of-intermittent-exotropia-on-sub-a-or-sub-v-pattern
#20
Young Bok Lee, Soolienah Rhiu, Joo Yeon Lee, Mi Young Choi, Hae Jung Paik, Key Hwan Lim, Dong Gyu Choi
We evaluated effect of horizontal rectus surgery on sub-A or sub-V pattern intermittent exotropia. We enrolled patients with sub-A or sub-V pattern intermittent exotropia. The sub-A pattern was diagnosed when the eyes diverged less than 10 prism diopters (PD) from upgaze to downgaze, and sub-V pattern when the divergence was 14 PD or less from downgaze to upgaze. Patients had undergone horizontal rectus surgery without vertical transposition of horizontal rectus muscle or oblique muscle weakening. The patients were divided into two groups: sub-A pattern (group A) and sub-V pattern (group V)...
2017: PloS One
keyword
keyword
21161
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"