keyword
https://read.qxmd.com/read/38536959/kit-ligand-and-kit-receptor-tyrosine-kinase-sustain-synaptic-inhibition-of-purkinje-cells
#1
JOURNAL ARTICLE
Tariq Zaman, Daniel Vogt, Jeremy Prokop, Qusai Abdulkhaliq Alsabia, Gabriel Simms, April Stafford, Bryan W Luikart, Michael R Williams
The cell-type-specific expression of ligand/receptor and cell-adhesion molecules is a fundamental mechanism through which neurons regulate connectivity. Here, we determine a functional relevance of the long-established mutually exclusive expression of the receptor tyrosine kinase Kit and the trans-membrane protein Kit Ligand by discrete populations of neurons in the mammalian brain. Kit is enriched in molecular layer interneurons (MLIs) of the cerebellar cortex (i.e., stellate and basket cells), while cerebellar Kit Ligand is selectively expressed by a target of their inhibition, Purkinje cells (PCs)...
March 27, 2024: ELife
https://read.qxmd.com/read/38536895/the-read-through-transcription-mediated-autoactivation-circuit-for-virulence-regulator-expression-drives-robust-type-iii-secretion-system-2-expression-in-vibrio-parahaemolyticus
#2
JOURNAL ARTICLE
Dhira Saraswati Anggramukti, Eiji Ishii, Andre Pratama, Mohamad Al Kadi, Tetsuya Iida, Toshio Kodama, Shigeaki Matsuda
Vibrio parahaemolyticus is the leading cause of seafood-borne gastroenteritis in humans worldwide. The major virulence factor responsible for the enteropathogenicity of this pathogen is type III secretion system 2 (T3SS2), which is encoded on the 80-kb V. parahaemolyticus pathogenicity island (Vp-PAI), the gene expression of which is governed by the OmpR-family transcriptional regulator VtrB. Here, we found a positive autoregulatory feature of vtrB transcription, which is often observed with transcriptional regulators of bacteria, but the regulation was not canonically dependent on its own promoter...
March 2024: PLoS Pathogens
https://read.qxmd.com/read/38536875/investigating-hill-sheep-farmers-and-crofters-experiences-of-blackloss-in-the-highlands-and-islands-of-scotland
#3
JOURNAL ARTICLE
Fiona McAuliffe, Ann McLaren, Neil Sargison, Franz Brülisauer, Andrew Kent, Davy McCracken
Hill sheep farming is an important component of Scottish agriculture and comprises a significant land use in much of the Highlands and Islands. However it faces significant challenges due to the natural constraints of the landscape. Hill sheep farming uses hardy traditional breeds, such as the Scottish blackface and North Country Cheviot to graze extensive areas, where the sheep are not housed and tend to lamb on the open hill. Flocks are gathered several times a year for stock checks, husbandry, and health treatments...
2024: PloS One
https://read.qxmd.com/read/38536873/quality-and-sustainability-of-ethiopia-s-national-surgical-indicators
#4
JOURNAL ARTICLE
Kayleigh R Cook, Zebenay B Zeleke, Ephrem Gebrehana, Daniel Burssa, Bantalem Yeshanew, Atkilt Michael, Yoseph Tediso, Taylor Jaraczewski, Chris Dodgion, Andualem Beyene, Katherine R Iverson
In 2015, the Ethiopian Federal Ministry of Health (FMOH) developed the Saving Lives through Safe Surgery (SaLTS) initiative to improve national surgical care. Previous work led to development and implementation of 15 surgical key performance indicators (KPIs) to standardize surgical data practices. The objective of this project is to investigate current practices of KPI data collection and assess quality to improve data management and strengthen surgical systems. The first portion of the study documented the surgical data collection process including methods, instruments, and effectiveness at 10 hospitals across 2 regions in Ethiopia...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536863/reinfection-of-farm-dogs-following-praziquantel-treatment-in-an-endemic-region-of-cystic-echinococcosis-in-southeastern-iran
#5
JOURNAL ARTICLE
Mehdi Borhani, Mohammad Ali Mohammadi, Mahbod Entezami, Mohammad Reza Baneshi, Saeid Nasibi, Joaquin M Prada, Majid Fasihi Harandi
Cystic Echinococcosis (CE) as a prevalent tapeworm infection of human and herbivorous animals worldwide, is caused by accidental ingestion of Echinococcus granulosus eggs excreted from infected dogs. CE is endemic in the Middle East and North Africa, and is considered as an important parasitic zoonosis in Iran. It is transmitted between dogs as the primary definitive host and different livestock species as the intermediate hosts. One of the most important measures for CE control is dog deworming with praziquantel...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536862/ultrastable-iodinated-oil-based-pickering-emulsion-enables-locoregional-sustained-codelivery-of-hypoxia-inducible-factor-1-inhibitor-and-anticancer-drugs-for-tumor-combination-chemotherapy
#6
JOURNAL ARTICLE
Zhihua Li, Xiaoya Liu, Jingyu Xiao, Hang Jiang, Le Ma, Yucheng Luo, Meijuan Wang, Yuwei Zhu, Hongliang Jiang, Hanyang Yao, To Ngai, Qiongyu Guo
Tumor hypoxia-associated drug resistance presents a major challenge for cancer chemotherapy. However, sustained delivery systems with a high loading capability of hypoxia-inducible factor-1 (HIF-1) inhibitors are still limited. Here, we developed an ultrastable iodinated oil-based Pickering emulsion (PE) to achieve locally sustained codelivery of a HIF-1 inhibitor of acriflavine and an anticancer drug of doxorubicin for tumor synergistic chemotherapy. The PE exhibited facile injectability for intratumoral administration, great radiopacity for in vivo examination, excellent physical stability (>1 mo), and long-term sustained release capability of both hydrophilic drugs (i...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38536852/barriers-and-facilitators-to-parents-engagement-with-and-perceived-impact-of-a-childhood-obesity-app-a-mixed-methods-study
#7
JOURNAL ARTICLE
Madison Milne-Ives, Em Rahman, Hannah Bradwell, Rebecca Baines, Timothy Boey, Alison Potter, Wendy Lawrence, Michelle Helena van Velthoven, Edward Meinert
Childhood obesity is a growing global health concern. Although mobile health apps have the potential to deliver behavioural interventions, their impact is commonly limited by a lack of sufficient engagement. The purpose of this study was to explore barriers and facilitators to engagement with a family-focused app and its perceived impact on motivation, self-efficacy, and behaviour. Parents with at least one child under 18 and healthcare professionals working with children were recruited; all participants were allocated to use the NoObesity app over a 6-month period...
March 2024: PLOS Digit Health
https://read.qxmd.com/read/38536773/comparison-of-nutritional-value-of-snakehead-fish-from-guangdong-and-deqing-varieties
#8
JOURNAL ARTICLE
Zeguo Zeng, Miao Zheng, Mengxiao Zhao, Jing Guo, Shuifa Zhu, Xianguo Zou, Qingxiang Zeng
Environmental pollution and overfishing of wild fish resources have led to a significant decrease in snakehead fish, thus leading to the increased demand for breeding the snakehead fish. Guangdong and Deqing snakehead fish are two common consumed varieties. However, their nutritional value was unclear. Therefore, this study aimed to evaluate the nutritional value of snakehead fish from Guangdong and Deqing varieties feeding with different fodders by analyzing and comparing the proximate composition, fatty acids and amino acids...
2024: PloS One
https://read.qxmd.com/read/38536760/nonpharmacologic-rate-control-of-postoperative-atrial-fibrillation-in-the-canine-sterile-pericarditis-model
#9
JOURNAL ARTICLE
Seungyup Lee, Don Wallick, Celeen Khrestian, Dragan Juzbasich, Daniel Laurita, Gregory Rushing, Jayakumar Sahadevan
INTRODUCTION: Postoperative atrial fibrillation (POAF) is common following open heart surgery, and is associated with significant morbidity. Medications used for ventricular rate control of POAF may not be effective in controlling rapid ventricular rates during the postoperative period because of increased sympathetic tone. The purpose of this study was to develop nonpharmacologic rate control of POAF by atrioventricular node (AVN) fat pad stimulation using clinically available temporary pacing wires in the canine sterile pericarditis model...
March 27, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38536729/energetic-comparison-of-flow-electrode-capacitive-deionization-and-membrane-technology-assessment-on-applicability-in-desalination-fields
#10
JOURNAL ARTICLE
Jihun Lim, Seonkyu Lee, Hyuncheal Lee, Seungkwan Hong
Flow-electrode capacitive deionization (FCDI) is a promising technology for sustainable water treatment. However, studies on the process have thus far been limited to lab-scale conditions and select fields of application. Such limitation is induced by several shortcomings, one of which is the absence of a comprehensive process model that accurately predicts the operational performance and the energy consumption of FCDI. In this study, a simulation model is newly proposed with initial validation based on experimental data and is then utilized to elucidate the performance and the specific energy consumption (SEC) of FCDI under multiple source water conditions ranging from near-groundwater to high salinity brine...
March 27, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38536670/tyrosinase-modified-uhmw-selp-polymers-as-wet-and-underwater-adhesives-to-achieve-multi-interface-adhesion
#11
JOURNAL ARTICLE
Wenxin Huang, Sijia Wang, Zhaoxuan Feng, Dasen Zhou, Wenqin Bai
The presence of a hydration layer in humid and underwater environments challenges adhesive-substrate interactions and prevents effective bonding, which has become a significant obstacle to the development of adhesives in the industrial and biomedical fields. In this study, ultrahigh-molecular-weight (UHMW) silk-elastin-like proteins (SELP) with 3,4-dihydroxyphenylalanine (DOPA) converted from tyrosine residues by tyrosinase exhibited excellent adhesive properties on different interfaces, such as glass, aluminum, wood, polypropylene sheets, and pigskin, under both dry and wet conditions...
March 27, 2024: ACS Synthetic Biology
https://read.qxmd.com/read/38536647/differences-in-injury-profiles-between-female-and-male-athletes-across-the-participant-classification-framework-a-systematic-review-and-meta-analysis
#12
Natalie J Hardaker, Patria A Hume, Stacy T Sims
BACKGROUND: Female sex is a significant determinant of anterior cruciate ligament (ACL) injury. It is not understood if sex is a key determinant of other sports-related injuries. OBJECTIVE: The aim of this systematic review was to identify where differences in injury profiles are most apparent between the sexes in all sports across the six-tiered participant classification framework. METHODS: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and the 'implementing PRISMA in Exercise, Rehabilitation, Sport medicine and SporTs science'(PERSiST) guidance...
March 27, 2024: Sports Medicine
https://read.qxmd.com/read/38536584/complications-of-outpatient-chest-tube-management-for-prolonged-air-leaks-after-pulmonary-surgery
#13
JOURNAL ARTICLE
Ryan J Randle, Prasha Bhandari, Hao He, Mark F Berry, Leah M Backhus, Natalie S Lui, Douglas Z Liou, Joseph B Shrager
PURPOSE: Air leaks are common after pulmonary surgery. Prolonged air leaks (PALs) may persist through discharge and often are managed with one-way valve devices (OWD). We sought to determine the course and complications of patients discharged with OWDs, risk factors for complications, and to evaluate the utility of clamp trials before chest tube (CT) removal. METHODS: Single-institution, retrospective review of patients discharged with a OWD after pulmonary surgery between 2008 and 2022...
March 27, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38536571/a-comprehensive-report-on-valorization-of-waste-to-single-cell-protein-strategies-challenges-and-future-prospects
#14
REVIEW
Sharda Devi Rajput, Neha Pandey, Keshavkant Sahu
The food insecurity due to a vertical increase in the global population urgently demands substantial advancements in the agricultural sector and to identify sustainable affordable sources of nutrition, particularly proteins. Single-cell protein (SCP) has been revealed as the dried biomass of microorganisms such as algae, yeast, and bacteria cultivated in a controlled environment. Production of SCP is a promising alternative to conventional protein sources like soy and meat, due to quicker production, minimal land requirement, and flexibility to various climatic conditions...
March 27, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38536570/assessing-the-effects-of-extreme-climate-risk-on-urban-ecological-resilience-in-china
#15
JOURNAL ARTICLE
Zongrun Wang, Haiqin Fu, Xiaohang Ren
The frequent occurrence of extreme weather events has imparted significant pressure on urban ecosystem management. Evaluating the relationship between extreme climate risk (ECR) and urban ecological resilience (UER) is a key issue in achieving the green and sustainable development objectives of cities. This study measures UER in China from 2005 to 2020 using the entropy weight method-TOPSIS method, investigates the relationship between ECR and UER using the dynamic GMM model, and further explores the influencing mechanism...
March 27, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38536528/identification-of-qtls-for-symbiotic-nitrogen-fixation-and-related-traits-in-a-soybean-recombinant-inbred-line-population
#16
JOURNAL ARTICLE
C Bennet Krueger, Jeffery D Ray, James R Smith, Arun Prabhu Dhanapal, Muhammad Arifuzzaman, Fei Gao, Felix B Fritschi
The genetic architecture of symbiotic N fixation and related traits was investigated in the field. QTLs were identified for percent N derived from the atmosphere, shoot [N] and C to N ratio. Soybean [Glycine max (L.) Merr.] is cultivated worldwide and is the most abundant source of plant-based protein. Symbiotic N2 fixation (SNF) in legumes such as soybean is of great importance; however, yields may still be limited by N in both high yielding and stressful environments. To better understand the genetic architecture of SNF and facilitate the development of high yielding cultivars and sustainable soybean production in stressful environments, a recombinant inbred line population consisting of 190 lines, developed from a cross between PI 442012A and PI 404199, was evaluated for N derived from the atmosphere (Ndfa), N concentration ([N]), and C to N ratio (C/N) in three environments...
March 27, 2024: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://read.qxmd.com/read/38536390/co2-photoreduction-over-semiconducting-2d-materials-with-supported-single-atoms-recent-progress-and-challenges
#17
JOURNAL ARTICLE
Zhangben Dai, Kejun Yang, Tianyi Yang, Yalin Guo, Jianfeng Huang
In the face of the growing energy crisis and environmental challenges, substantial efforts are now directed toward sustainable clean energy as a replacement for traditional fossil fuels. CO2 photoreduction into value-added chemicals and fuels is widely recognized as a promising approach to mitigate current energy and environmental concerns. Photocatalysts comprising single atoms (SAs) supported on two-dimensional (2D) semiconducting materials (SAs-2DSemi) have emerged as a novel frontier due to the combined merits of SA catalysts and 2D materials...
March 27, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38536236/outpatient-video-visits-during-the-covid-19-pandemic-cross-sectional-survey-study-of-patients-experiences-and-characteristics
#18
JOURNAL ARTICLE
Stefanie C van den Bosch, Demi van Dalen, Marjan Meinders, Harry van Goor, Stefaan Bergé, Martijn Stommel, Sandra van Dulmen
BACKGROUND: During the first lockdown of the COVID-19 pandemic, an exponential increase in video consultations replacing in-person outpatient visits was observed in hospitals. Insight into patients' experiences with this type of consultation is helpful for a broad, sustainable, and patient-centered implementation of video consultation. OBJECTIVE: This study aims to examine patients' experiences with video consultation during the COVID-19 pandemic and identify discriminative patient and consultation characteristics to determine when video consultation is most feasible...
March 27, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38536227/patient-education-and-decision-support-for-long-acting-injectable-hiv-antiretroviral-therapy-protocol-for-tool-development-and-pilot-testing-with-ryan-white-hiv-aids-program-medical-case-management-programs-in-new-york
#19
JOURNAL ARTICLE
Mary Kathryn Irvine, Rebecca Zimba, Tigran Avoundjian, Meghan Peterson, Connor Emmert, Sarah G Kulkarni, Morgan M Philbin, Elizabeth A Kelvin, Denis Nash
BACKGROUND: Long-acting injectable (LAI) HIV antiretroviral therapy (ART) presents a major opportunity to facilitate and sustain HIV viral suppression, thus improving health and survival among people living with HIV and reducing the risk of onward transmission. However, realizing the public health potential of LAI ART requires reaching patients who face barriers to daily oral ART adherence and thus can clinically benefit from alternative treatment modalities. Ryan White HIV/AIDS Program Part A medical case management (MCM) programs provide an array of services to address barriers to HIV care and treatment among economically and socially marginalized people living with HIV...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38536176/estimated-sustainable-cost-based-prices-for-diabetes-medicines
#20
JOURNAL ARTICLE
Melissa J Barber, Dzintars Gotham, Helen Bygrave, Christa Cepuch
IMPORTANCE: The burden of diabetes is growing worldwide. The costs associated with diabetes put substantial pressure on patients and health budgets, especially in low- and middle-income countries. The prices of diabetes medicines are a key determinant for access, yet little is known about the association between manufacturing costs and current market prices. OBJECTIVES: To estimate the cost of manufacturing insulins, sodium-glucose cotransporter 2 inhibitors (SGLT2Is), and glucagonlike peptide 1 agonists (GLP1As), derive sustainable cost-based prices (CBPs), and compare these with current market prices...
March 4, 2024: JAMA Network Open
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