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Zebrafish reproduction

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https://www.readbyqxmd.com/read/28526997/nafld-as-a-sexual-dimorphic-disease-role-of-gender-and-reproductive-status-in-the-development-and-progression-of-nonalcoholic-fatty-liver-disease-and-inherent-cardiovascular-risk
#1
REVIEW
Stefano Ballestri, Fabio Nascimbeni, Enrica Baldelli, Alessandra Marrazzo, Dante Romagnoli, Amedeo Lonardo
Nonalcoholic fatty liver disease (NAFLD) spans steatosis through nonalcoholic steatohepatis, cirrhosis, and hepatocellular carcinoma (HCC) associated with striking systemic features and excess cardiovascular and liver-related mortality. The pathogenesis of NAFLD is complex and multifactorial. Endocrine derangements are closely linked with dysmetabolic traits. For example, in animal and human studies, female sex is protected from dysmetabolism thanks to young individuals' ability to partition fatty acids towards ketone body production rather than very low density lipoprotein (VLDL)-triacylglycerol, and to sex-specific browning of white adipose tissue...
May 19, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28511137/effects-of-ibuprofen-diclofenac-and-paracetamol-on-hatch-and-motor-behavior-in-developing-zebrafish-danio-rerio
#2
Liang Xia, Liang Zheng, Jun Liang Zhou
Non-steroidal anti-inflammatory drugs (NSAIDs) which are widely used as pain relief medicines are causing increasing environmental concern due to their incomplete removal in wastewater treatment plant and potential toxicity on endocrine, kidney and reproduction in teleost fish. This study focused on the effects of widely used ibuprofen, diclofenac and paracetamol on the hatch and motor ability of early-stage zebrafish, by exposing embryos to the target chemicals at 5, 50 and 500 μg/L starting from 6 h postfertilization (hpf)...
May 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/28473760/persistent-effects-of-developmental-exposure-to-17%C3%AE-ethinylestradiol-on-the-zebrafish-danio-rerio-brain-transcriptome-and-behavior
#3
Tove Porseryd, Kristina Volkova, Nasim Reyhanian Caspillo, Thomas Källman, Patrik Dinnetz, Inger Porsh Hällström
The synthetic estrogen 17α-ethinylestradiol (EE2) is an endocrine disrupting compound of concern due to its persistence and widespread presence in the aquatic environment. Effects of developmental exposure to low concentrations of EE2 in fish on reproduction and behavior not only persisted to adulthood, but have also been observed to be transmitted to several generations of unexposed progeny. To investigate the possible biological mechanisms of the persistent anxiogenic phenotype, we exposed zebrafish embryos for 80 days post fertilization to 0, 3, and 10 ng/L EE2 (measured concentrations 2...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28461781/zebrafish-as-an-in-vivo-model-for-sustainable-chemical-design
#4
Pamela D Noyes, Gloria R Garcia, Robert L Tanguay
Heightened public awareness about the many thousands of chemicals in use and present as persistent contaminants in the environment has increased the demand for safer chemicals and more rigorous toxicity testing. There is a growing recognition that the use of traditional test models and empirical approaches is impractical for screening for toxicity the many thousands of chemicals in the environment and the hundreds of new chemistries introduced each year. These realities coupled with the green chemistry movement have prompted efforts to implement more predictive-based approaches to evaluate chemical toxicity early in product development...
December 21, 2016: Green Chemistry: An International Journal and Green Chemistry Resource: GC
https://www.readbyqxmd.com/read/28430864/the-gnih-lpxrfa-system-s-regulation-of-reproduction-in-the-brain-pituitary-axis-of-the-zebrafish-danio-rerio
#5
Olivia Smith Spicer, Nilli Zmora, Ten-Tsao Wong, Matan Golan, Berta Levavi-Sivan, Yoav Gothilf, Yonathan Zohar
Gonadotropin-inhibitory hormone (GNIH) was discovered in quail with the ability to reduce gonadotropin expression/secretion in the pituitary. There have been few studies on GNIH orthologs in teleosts (Lpxrfa peptides), which have provided inconsistent results. Therefore, the goal of this study was to determine the roles and modes of action by which Lpxrfa exerts its functions in the brain-pituitary axis of zebrafish (Danio rerio). We localized Lpxrfa soma to the ventral hypothalamus, with fibers extending throughout the brain and to the pituitary...
April 18, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28400274/characterization-of-gnrh-gnih-elements-in-the-olfacto-retinal-system-and-ovary-during-zebrafish-ovarian-maturation
#6
Sheryll Corchuelo, Emanuel R M Martinez, Arno J Butzge, Lucas B Doretto, Tanda N Valentin, Laura S O Nakaghi, Gustavo M Somoza, Rafael H Nóbrega
Gonadotropin releasing hormone (GnRH) is one of the key players of brain-pituitary-gonad axis, exerting overall control over vertebrate reproduction. In zebrafish, two variants were characterized and name as Gnrh2 and Gnrh3. In this species, Gnrh3, the hypohysiotropic form, is expressed by neurons of the olfactory-retinal system, where it is related with food detection, intra/interspecific recognition, visual acuity and retinal processing modulation. Previous studies have reported the presence of Gnrh receptors in the zebrafish retina, but not yet in the zebrafish olfactory epithelium...
April 8, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28398516/functional-analysis-of-nuclear-estrogen-receptors-ners-in-zebrafish-reproduction-by-genome-editing-approach
#7
Huijie Lu, Yong Cui, Liwen Jiang, Wei Ge
Estrogens signal through both nuclear and membrane receptors with most reported effects being mediated via the nuclear estrogen receptors (nERs). Although much work has been reported on nERs in the zebrafish, there is a lack of direct genetic evidence for their functional roles and importance in reproduction. To address this issue, we undertook this study to disrupt all three nERs in the zebrafish, namely esr1 (ERα), esr2a (ERβII) and esr2b (ERβI), by genome-editing technology CRISPR/Cas9. Using this loss-of-function genetic approach, we successfully created three mutant zebrafish lines with each nER knocked out...
April 10, 2017: Endocrinology
https://www.readbyqxmd.com/read/28375163/triazole-fungicides-inhibit-zebrafish-hatching-by-blocking-the-secretory-function-of-hatching-gland-cells
#8
Javiera F De la Paz, Natalia Beiza, Susana Paredes-Zúñiga, Misque S Hoare, Miguel L Allende
In animals, hatching represents the transition point from a developing embryo to a free-living individual, the larva. This process is finely regulated by many endogenous and environmental factors and has been shown to be sensitive to a variety of chemical agents. It is commonly evaluated in bioassays in order to establish the effects of different agents on early development and reproductive capabilities in fish and other aquatic animals. In fish, the breakdown of the chorion is achieved by the secretion of choriolysin by hatching gland cells (HGCs) into the perivitelline space (PVS), coupled with spontaneous movements of the developing larva...
April 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28360383/cloning-and-expression-analysis-of-zygote-arrest-1-zar1-in-new-zealand-white-rabbits
#9
Dan Wang, Shu-Yu Xie, Wei Zhang, Cai-Xia Sun, Tao Huang, An-Si Wang, Xue-Lei Han, Gui-Rong Sun, Ming Li
Zygote arrest 1 (Zar1) is an oocyte-specific maternal-effect gene. Previous studies indicate that Zar1 plays important role in early embryo development, but little is known about its function in rabbit. The objectives of this study were to clone the New Zealand white rabbit Zar1 gene and to investigate its expression in various organs in groups of animals with different reproductive traits.We obtained a 709-bp Zar1 cDNA fragment consisting of an 8-bp exon 1, 161-bp exon 2, 75-bp exon 3, 271-bp exon 4 and 194-bp 3'sequences...
March 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28359084/genetic-evidence-for-multifactorial-control-of-the-reproductive-axis-in-zebrafish
#10
Yun Liu, Haipei Tang, Rui Xie, Shuisheng Li, Xiaochun Liu, Haoran Lin, Yong Zhang, Christopher H K Cheng
It is generally believed that kisspeptin and gonadotropin-releasing hormone (GnRH) are required for reproduction in vertebrates. In this study, we generated gnrh3-null zebrafish and found that gnrh3 mutation did not impair gonad development and reproductive capacity. Moreover, zebrafish triple knockout mutant lacking gnrh3 and the 2 kiss1s genes undergo normal puberty and gonad maturation. The expression of follicle-stimulating hormone beta (fshβ) and luteinizing hormone beta (lhβ) was not significantly altered whereas the expression of neuropeptide Y (npy), tachykinin 3 (tac3), and secretogranin-II (sgII) was significantly increased in the triple knockout mutant, suggesting that compensation mechanisms exist to stimulate the reproductive axis in the absence of kiss and gnrh...
March 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28342328/reproductive-toxicity-of-%C3%AE-diketone-antibiotic-mixtures-to-zebrafish-danio-rerio
#11
Xuedong Wang, Yan Ma, Jinfeng Liu, Xiaohan Yin, Zhiheng Zhang, Caihong Wang, Yanyan Li, Huili Wang
So far, few data are available on the reproductive toxicological assessment of β-diketone antibiotics (DKAs), a class of ubiquitous pseudo-persistent pollutant, in zebrafish (Danio rerio). Herein, we reported the reproductive effects of DKAs by means of transcriptome analysis (F1-zebrafish), changes in a series of reproductive indices (F0-zebrafish) and histopathological observations. A total of 1170, 983 and 1399 genes were found to be differentially expressed when compared control vs. 6.25mg/L, control vs...
March 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28324048/demonstration-of-a-functional-kiss-kissr-system-in-amphioxus-with-implications-for-origin-of-neuroendocrine-regulation
#12
Peng Wang, Meng Wang, Guangdong Ji, Shuangshuang Yang, Shicui Zhang, Zhenhui Liu
Amphioxus belongs to the Cephalochordata, which is the most basal subphylum of the chordates. Despite many studies on the endocrine system of amphioxus, key information about its regulation remains ambiguous. Here we clearly demonstrated the presence of a functional kisspeptin/kisspeptin receptor (Kiss-Kissr) system, which is involved in the regulation of reproduction in amphioxus. Evolutionary analyses revealed large expansion of Kiss and Kissr (gpr54) genes in amphioxus and they might represent the ancestral type of the Kiss/gpr54 genes in chordates...
January 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/28295807/interaction-of-melatonin-and-gonadotropin-inhibitory-hormone-on-the-zebrafish-brain-pituitary-reproductive-axis
#13
Thangal Yumnamcha, Zeeshan A Khan, Chongtham Rajiv, Sijagurumayum D Devi, Gopinath Mondal, Haobijam Sanjita Devi, Rupjyoti Bharali, Asamanja Chattoraj
Circadian cycles and photoperiod are known to influence reproductive physiology in several animals. Neuropeptides, such as gonadotropin-inhibitory hormone (GNIH) and gonadotropin-releasing hormone (GNRH), are influenced by melatonin in birds and mammals. The present study demonstrates the role of melatonin in oocyte maturation in the zebrafish (Danio rerio), via the brain-pituitary-reproductive axis, under different photic conditions. Melatonin was significantly higher both in the whole brain and ovary under continuous dark (DD) compared to continuous light (LL) conditions...
March 10, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28274763/developmental-and-reproductive-toxicity-of-pvp-pei-coated-silver-nanoparticles-to-zebrafish
#14
Amaia Orbea, Nagore González-Soto, José María Lacave, Irantzu Barrio, Miren P Cajaraville
Cellular and molecular mechanisms of toxicity of silver nanoparticles (NPs) and their toxicity to fish embryos after waterborne exposure have been widely investigated, but much less information is available regarding the effect of Ag NPs on physiological functions such as growth or reproduction. In this work, the effects of waterborne exposure of adult zebrafish (Danio rerio) to PVP/PEI coated Ag NPs (~5nm) on reproduction (fecundity) were investigated. Moreover, the development of the embryos after parental exposure was compared with the development of embryos after direct waterborne exposure to the NPs...
March 6, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28213303/diethylstilbestrol-flutamide-and-their-combination-impaired-the-spermatogenesis-of-male-adult-zebrafish-through-disrupting-hpg-axis-meiosis-and-apoptosis
#15
Pan Yin, Ying-Wen Li, Qi-Liang Chen, Zhi-Hao Liu
Both diethylstilbestrol (DES, an environmental estrogen) and flutamide (FLU, an anti-androgen) are found to impair spermatogenesis by disrupting hypothalamic-pituitary-gonadal (HPG) axis and altering androgen levels through different mechanisms/modes of action in fish with poorly understood underlying mechanisms. Furthermore, it is not known whether and how a combined exposure of DES and FLU has a stronger effect than the compounds alone. In this study, male zebrafish adults were exposed to DES, FLU and their combination (DES+FLU) for 30days, and their effects on histological structure and sperm count in testis, androgen level in plasma, as well as the mRNA levels of genes involved in HPG axis, meiotic regulation and apoptosis were analyzed...
April 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28211501/high-resolution-3d-imaging-of-whole-organ-after-clearing-taking-a-new-look-at-the-zebrafish-testis
#16
Maxence Frétaud, Laurie Rivière, Élodie De Job, Stéphanie Gay, Jean-Jacques Lareyre, Jean-Stéphane Joly, Pierre Affaticati, Violette Thermes
Zebrafish testis has become a powerful model for reproductive biology of teleostean fishes and other vertebrates and encompasses multiple applications in applied and basic research. Many studies have focused on 2D images, which is time consuming and implies extrapolation of results. Three-dimensional imaging of whole organs recently became an important challenge to better understand their architecture and allow cell enumeration. Several protocols have thus been developed to enhance sample transparency, a limiting step for imaging large biological samples...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28118999/reproductive-and-transcriptional-effects-of-the-antiandrogenic-progestin-chlormadinone-acetate-in-zebrafish-danio-rerio
#17
Patricia Franziska Siegenthaler, Yanbin Zhao, Kun Zhang, Karl Fent
Chlormadinone acetate (CMA) is a frequently used progestin with antiandrogenic activity in humans. Residues may enter the aquatic environment but potential adverse effects in fish are unknown. While our previous work focused on effects of CMA in vitro and in zebrafish eleuthero-embryos, the present study reports on reproductive and transcriptional effects in adult female and male zebrafish (Danio rerio). We performed a reproductive study using breeding groups of zebrafish. After 15 days of pre-exposure, we exposed zebrafish to different measured concentrations between 6...
April 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28115725/heat-induced-masculinization-in-domesticated-zebrafish-is-family-specific-and-yields-a-set-of-different-gonadal-transcriptomes
#18
Laia Ribas, Woei Chang Liew, Noèlia Díaz, Rajini Sreenivasan, László Orbán, Francesc Piferrer
Understanding environmental influences on sex ratios is important for the study of the evolution of sex-determining mechanisms and for evaluating the effects of global warming and chemical pollution. Fishes exhibit sexual plasticity, but the underlying mechanisms of environmental effects on their reproduction are unclear even in the well-established teleost research model, the zebrafish. Here we established the conditions to study the effects of elevated temperature on zebrafish sex. We showed that sex ratio response to elevated temperature is family-specific and typically leads to masculinization (female-to-male sex reversal), resulting in neomales...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28111318/in-silico-predicted-reproductive-endocrine-transcriptional-regulatory-networks-during-zebrafish-danio-rerio-development
#19
D Hala
The interconnected topology of transcriptional regulatory networks (TRNs) readily lends to mathematical (or in silico) representation and analysis as a stoichiometric matrix. Such a matrix can be 'solved' using the mathematical method of extreme pathway (ExPa) analysis, which identifies uniquely activated genes subject to transcription factor (TF) availability. In this manuscript, in silico multi-tissue TRN models of brain, liver and gonad were used to study reproductive endocrine developmental programming in zebrafish (Danio rerio) from 0...
January 19, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28109900/microcystin-lr-retards-gonadal-maturation-through-disrupting-the-growth-hormone-insulin-like-growth-factors-system-in-zebrafish
#20
Jie Hou, Yujing Su, Wang Lin, Honghui Guo, Ping Xie, Jun Chen, Zemao Gu, Li Li
Recent studies have documented that microcystins (MCs) have potential toxic effects on growth and reproduction in fish. However, no systematic data exist on whether MCs cause gonadal development retardation through disrupting the growth hormone/insulin-like growth factors (GH/IGFs) system. To this end, zebrafish hatchlings (5 d post-fertilization) were exposed to 0, 0.3, 3 and 30µg/L microcystin-LR (MC-LR) for 90 d until they reached sexual maturity. Life-cycle exposure to MC-LR caused delayed ovarian maturation and sperm development along with ultrapathological lesions in the brain and liver...
May 2017: Ecotoxicology and Environmental Safety
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