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Zebrafish reproduction

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https://www.readbyqxmd.com/read/28067909/smchd1-mutations-associated-with-a-rare-muscular-dystrophy-can-also-cause-isolated-arhinia-and-bosma-arhinia-microphthalmia-syndrome
#1
Natalie D Shaw, Harrison Brand, Zachary A Kupchinsky, Hemant Bengani, Lacey Plummer, Takako I Jones, Serkan Erdin, Kathleen A Williamson, Joe Rainger, Alexei Stortchevoi, Kaitlin Samocha, Benjamin B Currall, Donncha S Dunican, Ryan L Collins, Jason R Willer, Angela Lek, Monkol Lek, Malik Nassan, Shahrin Pereira, Tammy Kammin, Diane Lucente, Alexandra Silva, Catarina M Seabra, Colby Chiang, Yu An, Morad Ansari, Jacqueline K Rainger, Shelagh Joss, Jill Clayton Smith, Margaret F Lippincott, Sylvia S Singh, Nirav Patel, Jenny W Jing, Jennifer R Law, Nalton Ferraro, Alain Verloes, Anita Rauch, Katharina Steindl, Markus Zweier, Ianina Scheer, Daisuke Sato, Nobuhiko Okamoto, Christina Jacobsen, Jeanie Tryggestad, Steven Chernausek, Lisa A Schimmenti, Benjamin Brasseur, Claudia Cesaretti, Jose E García-Ortiz, Tatiana Pineda Buitrago, Orlando Perez Silva, Jodi D Hoffman, Wolfgang Mühlbauer, Klaus W Ruprecht, Bart L Loeys, Masato Shino, Angela M Kaindl, Chie-Hee Cho, Cynthia C Morton, Richard R Meehan, Veronica van Heyningen, Eric C Liao, Ravikumar Balasubramanian, Janet E Hall, Stephanie B Seminara, Daniel Macarthur, Steven A Moore, Koh-Ichiro Yoshiura, James F Gusella, Joseph A Marsh, John M Graham, Angela E Lin, Nicholas Katsanis, Peter L Jones, William F Crowley, Erica E Davis, David R FitzPatrick, Michael E Talkowski
Arhinia, or absence of the nose, is a rare malformation of unknown etiology that is often accompanied by ocular and reproductive defects. Sequencing of 40 people with arhinia revealed that 84% of probands harbor a missense mutation localized to a constrained region of SMCHD1 encompassing the ATPase domain. SMCHD1 mutations cause facioscapulohumeral muscular dystrophy type 2 (FSHD2) via a trans-acting loss-of-function epigenetic mechanism. We discovered shared mutations and comparable DNA hypomethylation patterning between these distinct disorders...
January 9, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28053068/alternative-models-of-developmental-and-reproductive-toxicity-in-pharmaceutical-risk-assessment-and-the-3rs
#2
Kimberly C Brannen, Robert E Chapin, Abigail C Jacobs, Maia L Green
In the pharmaceutical industry, preclinical developmental and reproductive toxicity studies are conducted in laboratory animals in order to predict and prevent adverse effects of drugs on human reproductive health and development. However, these studies require a relatively large number of animals and are usually conducted late in the drug development process. Early, simple, and inexpensive screening assays could facilitate smarter decisions, reductions in animal use, and development of safe drugs. The current state and future needs for alternative models of developmental and reproductive toxicity are reviewed here...
December 2016: ILAR Journal
https://www.readbyqxmd.com/read/28007532/role-of-g-protein-coupled-estrogen-receptor-gper-gpr30-in-maintenance-of-meiotic-arrest-in-fish-oocytes
#3
REVIEW
Peter Thomas
An essential role for GPER (formerly known as GPR30) in regulating mammalian reproduction has not been identified to date, although it has shown to be involved in the regulation a broad range of other estrogen-dependent functions. In contrast, an important reproductive role for GPER in the maintenance of oocyte meiotic arrest has been identified in teleost fishes, which is briefly reviewed here. Recent studies have clearly shown that ovarian follicle production of estradiol-17β (E2) maintains meiotic arrest in several teleost species through activation of GPER coupled to a stimulatory G protein (Gs) on oocyte plasma membranes resulting in stimulation of cAMP production and maintenance of elevated cAMP levels...
December 19, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27988227/methods-for-the-analysis-of-early-oogenesis-in-zebrafish
#4
Yaniv M Elkouby, Mary C Mullins
Oocyte differentiation is a highly dynamic and intricate developmental process whose mechanistic understanding advances female reproduction, fertility, and ovarian cancer biology. Despite the many attributes of the zebrafish model, it has yet to be fully exploited for the investigation of early oocyte differentiation and ovarian development. This is partly because the properties of the adult zebrafish ovary make it technically challenging to access early stage oocytes. As a result, characterization of these stages has been lacking and tools for their analysis have been insufficient...
December 14, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27912163/reproduction-impairment-and-endocrine-disruption-in-adult-zebrafish-danio-rerio-after-waterborne-exposure-to-tboep
#5
Qinglong Xu, Ding Wu, Yao Dang, Liqin Yu, Chunsheng Liu, Jianghua Wang
Tris (2-butoxyethyl) phosphate (TBOEP) is widely used as a substitute of polybrominated diphenyl ethers (PBDEs). It has been frequently measured at concentrations of micrograms per liter (μg/L) in surface waters and waste water. However, limited information is available about the reproduction toxicology of TBOEP. In this study, adult zebrafish pairs were exposed to TBOEP at concentrations of 0, 5, 50, and 500μg/L for 21days. The effects on reproduction, hormone concentration, transcription of genes along the hypothalamic-pituitary-gonadal (HPG) axis, and gonadal development were investigated...
January 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/27880925/developmental-bisphenol-a-exposure-impairs-sperm-function-and-reproduction-in-zebrafish
#6
Jiangfei Chen, Katerine S Saili, Yueqin Liu, Lelin Li, Yuxin Zhao, Yinhang Jia, Chenglian Bai, Robert L Tanguay, Qiaoxiang Dong, Changjiang Huang
The developmental and reproductive toxicity of bisphenol A (BPA) has been demonstrated in a variety of model systems. Zebrafish (Danio rerio) were waterborne-exposed to BPA during three different developmental stages: embryonic period:6 h post fertilization (hpf) to 5 months post fertilization (mpf); larval period: 6 days post fertilization (dpf) to 5 mpf; and sexually mature period: 3 mpf to 5 mpf. Evaluations included F0 adult growth, reproduction parameters, and F1 offspring development. BPA exposure did not affect zebrafish growth in any of exposure groups...
February 2017: Chemosphere
https://www.readbyqxmd.com/read/27846271/igg-containing-isoforms-of-neuregulin-1-are-dispensable-for-cardiac-trabeculation-in-zebrafish
#7
Leigh Ann Samsa, Cade Ellis Ito, Daniel Ross Brown, Li Qian, Jiandong Liu
The Neuregulin-1 (Nrg1) signaling pathway has been widely implicated in many aspects of heart development including cardiac trabeculation. Cardiac trabeculation is an important morphogenetic process where clusters of ventricular cardiomyocytes extrude and expand into the lumen of the ventricular chambers. In mouse, Nrg1 isoforms containing an immunoglobulin-like (IgG) domain are essential for cardiac trabeculation through interaction with heterodimers of the epidermal growth factor-like (EGF-like) receptors ErbB2/ErbB4...
2016: PloS One
https://www.readbyqxmd.com/read/27815423/zebrafish-foxo3b-negatively-regulates-antiviral-response-through-suppressing-the-transactivity-of-irf3-and-irf7
#8
Xing Liu, Xiaolian Cai, Dawei Zhang, Chenxi Xu, Wuhan Xiao
Forkhead box O (FOXO)3, a member of the FOXO family of transcription factors, plays key roles in various cellular processes, including development, longevity, reproduction, and metabolism. Recently, FOXO3 has also been shown to be involved in modulating the immune response. However, how FOXO3 regulates immunity and the underlying mechanisms are still largely unknown. In this study, we show that zebrafish (Danio rerio) foxo3b, an ortholog of mammalian FOXO3, is induced by polyinosinic-polycytidylic acid stimulation and spring viremia of carp virus (SVCV) infection...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27814544/chemical-and-toxicological-characterisation-of-anticancer-drugs-in-hospital-and-municipal-wastewaters-from-slovenia-and-spain
#9
Marina Isidori, Margherita Lavorgna, Chiara Russo, Michael Kundi, Bojana Žegura, Matjaž Novak, Metka Filipič, Miroslav Mišík, Siegfried Knasmueller, Miren López de Alda, Damià Barceló, Božo Žonja, Marjeta Česen, Janez Ščančar, Tina Kosjek, Ester Heath
Anticancer drugs are continuously released into hospital and urban wastewaters, where they, most commonly, undergo conventional treatment in wastewater treatment plants (WWTPs). Wastewaters contain complex mixtures of substances including parent compounds, their metabolites and transformation products (TPs). In this study, samples of hospital effluents and WWTP influents and effluents from Slovenia and Spain were analyzed for twenty-two selected anticancer drugs, their metabolites and transformation products...
December 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27743222/reproductive-parameters-of-double-transgenic-zebrafish-danio-rerio-males-overexpressing-both-the-growth-hormone-gh-and-its-receptor-ghr
#10
Ana Cecilia Gomes Silva, Daniela Volcan Almeida, Bruna Felix Nornberg, Jessica Ribeiro Pereira, Diego Martins Pires, Carine Dahl Corcini, Antonio Sergio Varela Junior, Luis Fernando Marins
Growth hormone (GH) transgenesis presents a high potential application in aquaculture. However, excess GH may have serious consequences due to pleiotropic actions. In order to study these effects in zebrafish (Danio rerio), two transgenic lines were developed. The first expresses GH ubiquitously and constitutively (F0104 line), while the second expresses the GH receptor in a muscle-specific manner (Myo-GHR line). Results from the F0104 line showed accelerated growth but increased reproductive difficulties, while Myo-GHR did not show the expected increase in muscle mass...
October 14, 2016: Transgenic Research
https://www.readbyqxmd.com/read/27728887/vitellogenin-induction-and-reduced-fecundity-in-zebrafish-exposed-to-effluents-from-the-city-of-bulawayo-zimbabwe
#11
Charles Teta, Yogeshkumar S Naik
Industrial and municipal effluents regularly pollute water bodies and cause various toxic effects to aquatic life. Because of the diverse nature of industrial processes and domestic products, urban effluents are often tainted with various anthropogenic endocrine disrupting chemicals that may interfere with the reproductive physiology of aquatic fauna. In this study, we tested effluents from the City of Bulawayo for the presence of estrogenic endocrine disrupting chemicals and their effects on fish gonads and fecundity...
January 2017: Chemosphere
https://www.readbyqxmd.com/read/27666190/salmonella-spv-locus-suppresses-host-innate-immune-responses-to-bacterial-infection
#12
Shu-Yan Wu, Li-Dan Wang, Jin-Ling Li, Guang-Mei Xu, Mei-Ling He, Yuan-Yuan Li, Rui Huang
Salmonella enterica serovar typhimurium (S. typhimurium) is globally distributed and causes massive morbidity and mortality in humans and animals. S. typhimurium carries Salmonella plasmid virulence (spv) locus, which is highly conserved and closely related to bacterial pathogenicity, while its exact role in host immune responses during infection remains to be elucidated. To counteract the invaders, the host has evolved numerous strategies, among which the innate immunity and autophagy act as the first defense...
November 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27618422/corticosteroid-fludrocortisone-acetate-targets-multiple-end-points-in-zebrafish-danio-rerio-at-low-concentrations
#13
Yanbin Zhao, Kun Zhang, Karl Fent
Synthetic corticosteroids may pose an environmental risk to fish. Here, we describe multiend point responses of adult zebrafish (8 months old) upon 21-day exposure to a commonly prescribed corticosteroid, fludrocortisone acetate (FLU), at concentrations between 0.006 and 42 μg/L. No remarkable reproductive impacts were observed, while physiological effects, including plasma glucose level and blood leukocyte numbers were significant altered even at 42 ng/L. Ovary parameters and transcriptional analysis of hypothalamic-pituitary-gonadal-liver axis revealed negligible effects...
September 20, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27618130/histological-and-transcriptomic-changes-in-male-zebrafish-testes-due-to-early-life-exposure-to-low-level-2-3-7-8-tetrachlorodibenzo-p-dioxin
#14
Bridget B Baker, Jeremiah S Yee, Danielle N Meyer, Doris Yang, Tracie R Baker
We have shown that zebrafish (Danio rerio) are an excellent model for evaluating the link between early life stage exposure to environmental chemicals and disease in adulthood and subsequent unexposed generations. Previously, we used this model to identify transgenerational effects of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin [TCDD]) on skeletal development, sex ratio, and reproductive capacity. Transgenerational inheritance of TCDD toxicity, notably decreased reproductive capacity, appears to be mediated through the male germ line...
October 2016: Zebrafish
https://www.readbyqxmd.com/read/27618129/mixtures-metabolites-and-mechanisms-understanding-toxicology-using-zebrafish
#15
Joshua T Gamse, Daniel A Gorelick
For more than 60 years, zebrafish have been used in toxicological studies. Due to their transparency, genetic tractability, and compatibility with high-throughput screens, zebrafish embryos are uniquely suited to study the effects of pharmaceuticals and environmental insults on embryonic development, organ formation and function, and reproductive success. This special issue of Zebrafish highlights the ways zebrafish are used to investigate the toxic effects of endocrine disruptors, pesticides, and heavy metals...
October 2016: Zebrafish
https://www.readbyqxmd.com/read/27616647/reproductive-toxicity-of-azoxystrobin-to-adult-zebrafish-danio-rerio
#16
Fangjie Cao, Lizhen Zhu, Hui Li, Song Yu, Chengju Wang, Lihong Qiu
In the past few decades, extensive application of azoxystrobin has led to great concern regarding its adverse effects on aquatic organisms. The objective of the present study was to evaluate the reproductive toxicity of azoxystrobin to zebrafish. After adult zebrafish of both sexes were exposed to 2, 20 and 200 μg/L azoxystrobin for 21 days, egg production, the fertilization rate, the gonadosomatic index (GSI) and hepatosomatic index (HSI), 17β-estradiol (E2), testosterone (T) and vitellogenin (Vtg) concentrations, and histological alterations in the gonads and livers were measured...
December 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27611220/impairment-of-reproduction-of-adult-zebrafish-danio-rerio-by-binary-mixtures-of-environmentally-relevant-concentrations-of-triclocarban-and-inorganic-mercury
#17
Pingping Wang, Zhongkun Du, Shixiang Gao, Xiaowei Zhang, J P Giesy
Effects of chemical mixtures at environmentally relevant concentrations on endocrine systems of aquatic organisms are of concern. Triclocarban (TCC) and inorganic mercury (Hg(2+)) are ubiquitous in aquatic environments, and are known to interfere with endocrine pathways via different mechanisms of toxic action. However, effects of mixtures of the two pollutants on aquatic organisms and associated molecular mechanisms were unknown. This study examined effects of binary mixtures of TCC and Hg(2+) on histopathological and biochemical alteration of reproductive organs in zebrafish (Danio rerio) after 21 d exposure...
September 6, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27580802/neurokinin-b-exerts-direct-effects-on-the-ovary-to-stimulate-estradiol-production
#18
Xin Qi, Mohamed Salem, Wenyi Zhou, Miwa Sato-Shimizu, Gang Ye, Johan Smitz, Chun Peng
Neurokinin B (NKB) and its receptor, NK3R, play critical roles in reproduction by regulating the secretion of the hypothalamic GnRH. NKB and NK3R genes are also expressed in the ovary; however, their physiological roles within the ovary are unknown. The aim of this study was to determine whether NKB acts directly on the ovary to regulate reproduction. Injection of NKB into zebrafish accelerated follicle development, increased the mRNA levels of cyp11a1 and cyp19a1, and enhanced estradiol production. Similarly, NKB induced cyp11a1 and cyp19a1 expression in primary cultures of zebrafish follicular cells and stimulated estradiol production from cultured follicles...
September 2016: Endocrinology
https://www.readbyqxmd.com/read/27577093/phage-display-and-structural-studies-reveal-plasticity-in-substrate-specificity-of-caspase-3a-from-zebrafish
#19
Matthew B Tucker, Sarah H MacKenzie, Joseph J Maciag, Hayley Dirscherl Ackerman, Paul Swartz, Jeffrey A Yoder, Paul T Hamilton, A Clay Clark
The regulation of caspase-3 enzyme activity is a vital process in cell fate decisions leading to cell differentiation and tissue development or to apoptosis. The zebrafish, Danio rerio, has become an increasingly popular animal model to study several human diseases because of their transparent embryos, short reproductive cycles, and ease of drug administration. While apoptosis is an evolutionarily conserved process in metazoans, little is known about caspases from zebrafish, particularly regarding substrate specificity and allosteric regulation compared to the human caspases...
November 2016: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/27574813/effects-of-%C3%AE-diketone-antibiotics-on-f1-zebrafish-danio-rerio-based-on-high-throughput-mirna-sequencing-under-exposure-to-parents
#20
Yuansi Zheng, Jiebo Lin, Jieyi Li, Haifeng Zhang, Weiming Ai, Xuedong Wang, Randy A Dahlgren, Huili Wang
The toxicity of β-diketone antibiotics (DKAs), a class of ''pseudo-persistent'' environmental pollutants, to F0-zebrafish (Danio rerio) was investigated using 7-dpf F1-zebrafish miRNA sequencing and bioinformatics analyses. Based on relative expression, 47, 134 and 118 of 193 mature miRNAs were differentially expressed between control vs 6.25 mg/L, control vs 12.5 mg/L and 6.25 vs 12.5 mg/L treatments, respectively. Utilizing three databases, 2523 potential target genes were predicted, and they were assigned to 19 high-abundance KEGG pathways and 20 functional categories by COG analysis...
December 2016: Chemosphere
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