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https://www.readbyqxmd.com/read/29040910/intensity-inhomogeneity-correction-of-sd-oct-data-using-macular-flatspace
#1
Andrew Lang, Aaron Carass, Bruno M Jedynak, Sharon D Solomon, Peter A Calabresi, Jerry L Prince
Images of the retina acquired using optical coherence tomography (OCT) often suffer from intensity inhomogeneity problems that degrade both the quality of the images and the performance of automated algorithms utilized to measure structural changes. This intensity variation has many causes, including off-axis acquisition, signal attenuation, multi-frame averaging, and vignetting, making it difficult to correct the data in a fundamental way. This paper presents a method for inhomogeneity correction by acting to reduce the variability of intensities within each layer...
October 12, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29040839/effects-of-the-dietary-carbohydrate-fat-ratio-on-plasma-phosphatidylcholine-profiles-in-human-and-mouse
#2
Mizuki Inoue, Nanami Senoo, Tomoki Sato, Yuri Nishimura, Takumi Nakagawa, Noriyuki Miyoshi, Toshinao Goda, Akihito Morita, Shinji Miura
Phosphatidylcholines (PCs), a major class of human plasma phospholipids, are composed of highly diverse fatty acids. Because the dietary carbohydrate-fat ratio alters the hepatic fatty acid metabolism, plasma fatty acids that bind PCs, which are secreted as lipoproteins from the liver, may be affected by long-term consumption of a high-carbohydrate diet or a high-fat diet. Therefore, in this study, we profiled the plasma PC species comprehensively in formulated dieting conditions to identify those phospholipid molecules that reflect the dietary carbohydrate-fat ratio...
September 15, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29040623/socio-economic-trajectories-and-cardiovascular-disease-mortality-in-older-people-the-english-longitudinal-study-of-ageing
#3
Silvia Stringhini, Paola Zaninotto, Meena Kumari, Mika Kivimäki, Camille Lassale, G David Batty
Background: Socio-economic status from early life has been linked to cardiovascular disease risk, but the impact of life-course socio-economic trajectories, as well as the mechanisms underlying social inequalities in cardiovascular disease risk, is uncertain. Objectives: We assessed the role of behavioural, psychosocial and physiological (including inflammatory) factors in the association between life-course socio-economic status and cardiovascular disease mortality in older adults...
July 28, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29040588/glyphosate-resistance-and-epsps-gene-duplication-convergent-evolution-in-multiple-plant-species
#4
Eric L Patterson, Dean J Pettinga, Karl Ravet, Paul Neve, Todd A Gaines
One of the increasingly widespread mechanisms of resistance to the herbicide glyphosate is copy number variation (CNV) of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene. EPSPS gene duplication has been reported in eight weed species, ranging from 3-5 extra copies to more than 150 extra copies. In the case of Palmer amaranth (Amaranthus palmeri), a section of >300 kb containing EPSPS and many other genes has been replicated and inserted at new loci throughout the genome, resulting in significant increase in total genome size...
October 10, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29040443/a-dysbiosis-index-to-assess-microbial-changes-in-fecal-samples-of-dogs-with-chronic-inflammatory-enteropathy
#5
M K AlShawaqfeh, B Wajid, Y Minamoto, M Markel, J A Lidbury, J M Steiner, E Serpedin, J S Suchodolski
Recent studies have identified various bacterial groups that are altered in dogs with chronic inflammatory enteropathies (CE) compared to healthy dogs. The study aim was to use quantitative PCR (qPCR) assays to confirm these findings in a larger number of dogs, and to build a mathematical algorithm to report these microbiota changes as a dysbiosis index (DI). Fecal DNA from 95 healthy dogs and 106 dogs with histologically confirmed CE was analyzed. Samples were grouped into a training set and a validation set...
October 11, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29040425/apparent-age-is-a-reliable-assessment-tool-in-20-facelift-patients
#6
Russell S Frautschi, Eliana F Duraes, Kashyap K Tadisina, Rafael A Couto, James E Zins
Background: Although the literature is replete with favorable facelift results, there are few validated facial rejuvenation outcome measures. Apparent age (AA), a visual estimate of age by objective observers, has been utilized in several studies; although attractive, AA lacks validation. Objective: The aim of this study is to examine the reliability of AA, highlighting the importance of the exclusive use of validated outcome measures in future studies. Methods: Ten blinded reviewers assessed pre- and postoperative photographs of 32 patients who underwent facelift...
September 18, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29040287/antimicrobial-activity-of-carbon-monoxide-releasing-molecule-mn-co-3-tpa-%C3%AE%C2%BA3n-br-versus-multidrug-resistant-isolates-of-avian-pathogenic-escherichia-coli-and-its-synergy-with-colistin
#7
Jonathan Betts, Christopher Nagel, Ulrich Schatzschneider, Robert Poole, Robert M La Ragione
Antimicrobial resistance is a growing global concern in human and veterinary medicine, with an ever-increasing void in the arsenal of clinicians. Novel classes of compounds including carbon monoxoide-releasing molecules (CORMs), for example the light-activated metal complex [Mn(CO)3(tpa-κ3N)]Br, could be used as alternatives/to supplement traditional antibacterials. Avian pathogenic Escherichia coli (APEC) represent a large reservoir of antibiotic resistance and can cause serious clinical disease in poultry, with potential as zoonotic pathogens, due to shared serotypes and virulence factors with human pathogenic E...
2017: PloS One
https://www.readbyqxmd.com/read/29040086/compliance-of-brown-mussel-perna-perna-production-areas-in-the-south-of-brazil-with-the-bacteriological-criteria-of-the-shellfish-hygiene-systems-in-the-european-union-and-united-states-of-america-assessing-the-impacts-on-consumer-safety
#8
Robson Ventura de Souza, Carlos José Alexandre de Campos, Luis Hamilton Pospissil Garbossa, Walter Quadros Seiffert
Levels of faecal indicator organisms (FIOs) monitored in surface water and brown mussels collected at 28 production areas in Brazil from August 2012 to October 2013 were used to assess compliance with the bacteriological standards of the shellfish hygiene classification systems used in the European Union (EU) and USA. This classification determines the level of post-harvesting purification needed to reduce the risk of illness in consumers. The results indicate that 36% of production areas would be class A under the EU system and 75% would be 'Approved' under the US system...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29040081/characterization-of-extended-spectrum-%C3%AE-lactamase-esbl-producing-escherichia-coli-in-asi-orontes-river-in-turkey
#9
Cemil Kürekci, Muhsin Aydin, Mustafa Yipel, Mohammad Katouli, Aycan Gündoğdu
In this study, the presence of extended spectrum β-lactamase (ESBL)-producing Escherichia coli in aquatic environments (the Orontes River and an urban wastewater) was investigated. Fifty-four E. coli strains resistant to cefotaxime were isolated from the river waters and nearby waste water treatment plant and screened for ESBL gene variants, different classes of integrons and sulfonamide resistance genes. The ESBL-producing E. coli strains were further characterized by PhP-typing system, phylogenetic grouping and antimicrobial susceptibility testing...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29039983/potential-information-loss-due-to-categorization-of-minimum-inhibitory-concentration-frequency-distributions
#10
Reza Mazloom, Majid Jaberi-Douraki, Jeffrey R Comer, Victoriya Volkova
A bacterial isolate's susceptibility to antimicrobial is expressed as the lowest drug concentration inhibiting its visible growth, termed minimum inhibitory concentration (MIC). The susceptibilities of isolates from a host population at a particular time vary, with isolates with specific MICs present at different frequencies. Currently, for either clinical or monitoring purposes, an isolate is most often categorized as Susceptible, Intermediate, or Resistant to the antimicrobial by comparing its MIC to a breakpoint value...
October 17, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29039949/highly-efficient-red-emitting-carbon-dots-with-gram-scale-yield-for-bioimaging
#11
Hui Ding, Ji-Shi Wei, Ning Zhong, Qingyu Gao, Huan-Ming Xiong
Carbon dots (CDs) are a new class of photoluminescent (PL), biocompatible, environment friendly and low-cost carbon nanomaterials. Synthesis of highly efficient red-emitting carbon dots (R-CDs) on a gram scale is a great challenge at present, which heavily restricts the wide applications of CDs in the bioimaging field. Herein, R-CDs with a high quantum yield (QY) of 53% are produced on a gram scale by heating a formamide solution of citric acid and ethylenediamine. The as-prepared R-CDs have an average size of 4...
October 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29039940/the-radical-s-adenosylmethionine-methylase-nosn-catalyzes-both-c1-transfer-and-formation-of-the-ester-linkage-of-the-side-ring-system-during-the-biosynthesis-of-nosiheptide
#12
Joseph W LaMattina, Bo Wang, Edward D Badding, Lauren K Gadsby, Tyler Grove, Squire J Booker
Nosiheptide, a member of the e series of macrocyclic thiopeptide natural products, contains a side-ring system composed of a 3,4-dimethylindolic acid (DMIA) moiety connected to Glu6 and Cys8 of the thiopeptide backbone via ester and thioester linkages, respectively. Herein, we show that NosN, a predicted class C radical S-adenosylmethionine (SAM) methylase, catalyzes both the transfer of a C1 unit from SAM to 3-methylindolic acid linked to Cys8 of a synthetic substrate surrogate as well as the formation of the ester linkage between Glu6 and the nascent C4 methylene moiety of DMIA...
October 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29039937/concentration-independent-stereodynamic-g-probe-for-chiroptical-enantiomeric-excess-determination
#13
Paolo Zardi, Klaus Wurst, Giulia Licini, Cristiano Zonta
Enantiomeric excess determination is crucial in many aspects of science ranging from synthesis to materials. Within this subject, the use of molecular sensors coupled with chiroptical techniques is a straightforward approach to the stereochemical analysis of chiral molecules, especially in terms of process immediacy and labor. Ste-reodynamic probes typically consist of racemic mixtures of rapidly interconverting enantiomeric conformers able to recognize a chiral analyte and greatly amplify its chiroptical readout...
October 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29036989/-dissemination-of-insertion-sequence-common-regions-1-and-int1-gene-and-drug-resistance-of-483-escherichia-coli-and-klebsiella-pneumonia-broiler-isolates
#14
X Chen, J Che, X F Zhao, L F Zhang, J Li
Objective: To investigate and analyze distribution characteristics of two multidrug resistance related genes in broiler isolates in Shandong province. Methods: The pre slaughter broilers were chosen from Shandong province in this study in June, 2014. A total of 400 fecal samples from five different zones (east, south, west, north and middle) of the hen house were collected. 373(77.2%) Escherichia coli and 110 (22.8%) Klebsiella pneumonia strains were isolated, and ISCR1 and int1 gene were detected by PCR assay and sequencing...
October 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29036936/barriers-and-facilitators-for-health-behavior-change-among-adults-from-multi-problem-households-a-qualitative-study
#15
Gera E Nagelhout, Lette Hogeling, Renate Spruijt, Nathalie Postma, Hein de Vries
Multi-problem households are households with problems on more than one of the following core problem areas: socio-economic problems, psycho-social problems, and problems related to child care. The aim of this study was to examine barriers and facilitators for health behavior change among adults from multi-problem households, as well as to identify ideas for a health promotion program. A qualitative study involving 25 semi-structured interviews was conducted among Dutch adults who received intensive family home care for multi-problem households...
October 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29036808/ecotropic-viral-integration-site-5-evi5-expression-analysis-in-multiple-sclerosis-patients
#16
Mehrdokht Mazdeh, Mahnoosh Rahimi, Mohammad Mahdi Eftekharian, Mir Davood Omrani, Arezou Sayad, Mohammad Taheri, Soudeh Ghafouri-Fard
BACKGROUND: Multiple sclerosis (MS) is a complex immune-related disorder of the central nervous system (CNS) in which dysregulation of different classes of T cells are involved. Variants in Ecotropic Viral Integration Site 5 (EVI5) gene has been shown to be significantly associated with MS in different populations. OBJECTIVES: However, there is no data regarding relative expression of this gene in peripheral blood of MS patients compared with healthy controls. METHODS: In the present study we assessed expression of EVI5 in 50 Iranian MS patients compared with healthy subjects by means of quantitative real time RT-PCR...
September 8, 2017: Human Antibodies
https://www.readbyqxmd.com/read/29036678/country-of-residence-gender-equality-and-victim-blaming-attitudes-about-partner-violence-a-multilevel-analysis-in-eu
#17
Anna-Karin Ivert, Juan Merlo, Enrique Gracia
Background: Intimate partner violence against women (IPVAW) is a global and preventable public health problem. Public attitudes, such as victim-blaming, are important for our understanding of differences in the occurrence of IPVAW, as they contribute to its justification. In this paper, we focus on victim-blaming attitudes regarding IPVAW within the EU and we apply multilevel analyses to identify contextual determinants of victim-blaming attitudes. We investigate both the general contextual effect of the country and the specific association between country level of gender equality and individual victim-blaming attitudes, as well as to what extend a possible general contextual effect was explained by county level gender equality...
September 27, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29036674/detecting-and-characterizing-micrornas-of-diverse-genomic-origins-via-mirvial
#18
Jing Xia, Lun Li, Tiantian Li, Zhiwei Fang, Kevin Zhang, Junfei Zhou, Hai Peng, Weixiong Zhang
MicroRNAs form an essential class of post-transcriptional gene regulator of eukaryotic species, and play critical parts in development and disease and stress responses. MicroRNAs may originate from various genomic loci, have structural characteristics, and appear in canonical or modified forms, making them subtle to detect and analyze. We present miRvial, a robust computational method and companion software package that supports parameter adjustment and visual inspection of candidate microRNAs. Extensive results comparing miRvial and six existing microRNA finding methods on six model organisms, Mus musculus, Drosophila melanogaste, Arabidopsis thaliana, Oryza sativa, Physcomitrella patens and Chlamydomonas reinhardtii, demonstrated the utility and rigor of miRvial in detecting novel microRNAs and characterizing features of microRNAs...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036659/derivation-of-occupational-thresholds-of-toxicological-concern-for-systemically-acting-noncarcinogenic-organic-chemicals
#19
Sandrine F Chebekoue, Kannan Krishnan
Many substances in workplace do not have occupational exposure limits. The threshold of toxicological concern (TTC) principle is part of the hierarchy of approaches useful in occupational health risk assessment. The aim of this study was to derive occupational TTCs (OTTCs) reflecting the airborne concentrations below which no significant risk to workers would be anticipated. A reference dataset consisting of the 8-h threshold limit values-Time-Weighted Average for 280 organic substances was compiled. Each substance was classified into low (class I), intermediate (class II), or high (class III) hazard categories as per Cramer rules...
August 2, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29036653/mircarta-a-central-repository-for-collecting-mirna-candidates
#20
Christina Backes, Tobias Fehlmann, Fabian Kern, Tim Kehl, Hans-Peter Lenhof, Eckart Meese, Andreas Keller
The continuous increase of available biological data as consequence of modern high-throughput technologies poses new challenges for analysis techniques and database applications. Especially for miRNAs, one class of small non-coding RNAs, many algorithms have been developed to predict new candidates from next-generation sequencing data. While the amount of publications describing novel miRNA candidates keeps steadily increasing, the current gold standard database for miRNAs - miRBase - has not been updated since June 2014...
September 25, 2017: Nucleic Acids Research
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