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https://www.readbyqxmd.com/read/29908478/effect-of-magnesium-oxide-nanoparticles-on-microbial-diversity-and-removal-performance-of-sequencing-batch-reactor
#1
Bingrui Ma, Naling Yu, Yuetong Han, Mengchun Gao, Sen Wang, Shanshan Li, Liang Guo, Zonglian She, Yangguo Zhao, Chunji Jin, Feng Gao
The performance, microbial enzymatic activity and microbial community of a sequencing batch reactor (SBR) have been explored under magnesium oxide nanoparticles (MgO NPs) stress. The NH4 + -N removal efficiency kept relatively stable during the whole operational process. The MgO NPs at 30-60 mg/L slightly restrained the removal of chemical oxygen demand (COD), and the presence of MgO NPs also affected the denitrification and phosphorus removal. The specific oxygen uptake rate, nitrifying and denitrifying rates, phosphorus removal rate, and microbial enzymatic activities distinctly varied with the increase of MgO NPs concentration...
June 13, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29908464/reduction-of-antibiotic-resistome-and-integron-integrase-genes-in-laboratory-scale-photobioreactors-treating-municipal-wastewater
#2
Hiie Nõlvak, Marika Truu, Kristjan Oopkaup, Kärt Kanger, Ivo Krustok, Emma Nehrenheim, Jaak Truu
Wastewater treatment systems receiving municipal wastewater are major dissemination nodes of antibiotic resistance genes (ARGs) between anthropogenic and natural environments. This study examined the fate of antibiotic resistome and class 1-3 integron-integrase genes in photobioreactors that were treating municipal wastewater diluted (70/30) with lake or tap water for the algal biomass production. A combined approach of metagenomic and quantitative (qPCR) analysis was undertaken. Municipal wastewater treatment in the photobioreactors led to reduced antibiotic resistome proportion, number of ARG subtypes, and abundances of individual ARGs in the bacterial community...
June 8, 2018: Water Research
https://www.readbyqxmd.com/read/29908444/synthesis-and-biological-evaluation-of-novel-2-oxo-1-2-dihydroquinoline-4-carboxamide-derivatives-for-the-treatment-of-esophageal-squamous-cell-carcinoma
#3
Mai I Shahin, Joyeeta Roy, Maha Hanafi, Dongyao Wang, Urarika Luesakul, Yifeng Chai, Nongnuj Muangsin, Deena S Lasheen, Dalal A Abou El Ella, Khaled A Abouzid, Nouri Neamati
No new and effective treatments have been approved for the treatment of esophageal squamous cell carcinoma (ESCC) in the past decade. Cisplatin and 5-fluoruracil are the most commonly used drugs for this disease. In order to develop a new class of drugs effective in our ESCC phenotypic screens, we began a systematic approach to generate novel compounds based on the 2-oxo-1,2-dihydroquinoline-4-carboxamide fragment. Herein, we report on the synthesis and initial assessment of 55 new analogues in two ESCC cell lines...
May 29, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29908411/transitions-through-stages-of-alcohol-involvement-the-potential-role-of-mood-disorders
#4
Rosa M Crum, Kerry M Green, Elizabeth A Stuart, Lareina N La Flair, Marc Kealhofer, Andrea S Young, Noa Krawczyk, Kayla N Tormohlen, Carla L Storr, Anika A H Alvanzo, Ramin Mojtabai, Lauren R Pacek, Bernadette A Cullen, Beth A Reboussin
INTRODUCTION: Although prior clinical and population-based studies have demonstrated comorbidity between mood and alcohol use disorders (AUD), there is a paucity of research assessing whether mood disorders predict transition across stages of alcohol involvement. METHOD: Hypothesizing that mood disorders predict transition across sex-specific alcohol involvement stages, we used prospective data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a nationally representative survey of US adults, which included male (n = 14,564) and female (n = 20,089) participants surveyed in 2001-2 and re-interviewed in 2004-5...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29908409/heroism-and-nursing-a-thematic-review-of-the-literature
#5
REVIEW
Kathleen MacDonald, Jessica De Zylva, Margaret McAllister, Donna Lee Brien
OBJECTIVES: Nursing history is replete with examples of heroic individuals acting courageously to meet the needs of vulnerable patients and communities. Heroism exemplifies the pinnacle of self-actualised behaviour. It fuels the plots of countless human stories, and enthrals and inspires people. Yet, heroism may be seen as an extreme behaviour that only exceptional individuals are capable of enacting, and may thus be seen as out of reach for ordinary nurses, and something that could be risky to teach and disseminate...
June 8, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29908407/antenatal-education-for-childbirth-epidural-analgesia
#6
Lisa Cutajar, Allan M Cyna
The language structures used by antenatal educators have not been previously researched in the context of antenatal childbirth classes. Epidural analgesia for labour is a common, and a frequently asked about, component of antenatal education for parents in hospitals providing maternity care. AIM OF THE STUDY: We aimed to identify the way information is described and presented by childbirth educators to assess content and determine which language structures such as metaphor, suggestion, information and storytelling are utilized...
May 7, 2018: Midwifery
https://www.readbyqxmd.com/read/29908389/development-and-validation-of-a-clinical-prediction-tool-to-estimate-the-individual-risk-of-depressive-relapse-or-recurrence-in-individuals-with-recurrent-depression
#7
Nicola S Klein, Gea A Holtman, Claudi L H Bockting, Martijn W Heymans, Huibert Burger
OBJECTIVES: Many studies examined predictors of depressive relapse/recurrence but no simple tool based on well-established risk factors is available that estimates the risk within an individual. We developed and validated such a prediction tool in remitted recurrently depressed individuals. METHODS: The tool was developed using data (n = 235) from a pragmatic randomised controlled trial in remitted recurrently depressed participants and externally validated using data (n = 209) from a similar randomised controlled trial of remitted recurrently depressed participants using maintenance antidepressants...
June 8, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29908284/downregulation-of-scara5-may-contribute-to-breast-cancer-via-promoter-hypermethylation
#8
Damla Ulker, Yeliz Emine Ersoy, Zuhal Gucin, Mahmut Muslumanoglu, Nur Buyru
Breast cancer is the most common malignant tumor in women worldwide. Breast tumors mostly exhibit aberrant gene expression and DNA hypermethylation patterns that predispose the disease. Understanding the genetic and epigenetic factors that contribute to breast cancer development is important to identify novel diagnostic and prognostic markers. SCARA5: Scavenger receptor class A, member 5; is a member of the scavenger receptor family located on chromosome 8p21 which is a frequently deleted region in human cancers...
June 13, 2018: Gene
https://www.readbyqxmd.com/read/29908246/refractory-ceramic-fibers-fiber-characteristics-potential-health-effects-and-clinical-observations
#9
Mark J Utell, L Daniel Maxim
Refractory ceramic fibers (RCFs) are amorphous fibers that belong to a class of materials termed synthetic vitreous fibers (SVFs), also called man-made mineral fibers (MMMFs), which includes alkaline earth silicate wool, glass wool, rock (stone) wool, slag wool, and special-purpose glass fibers. RCFs are more durable and biopersistent than several other SVFs, although very much less biopersistent than either amosite or crocidolite asbestos. Chronic inhalation studies indicated that rats and hamsters exposed to RCF fibers developed fibrosis and tumors...
June 13, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29908213/genetic-diversity-of-the-hla-system-in-human-populations-from-the-sierra-andean-oriente-amazonian-and-costa-coastal-regions-of-ecuador
#10
Juan M Galarza, Rodrigo Barquera, Ana M Tito Álvarez, Diana I Hernández Zaragoza, Gabriela Peralta Sevilla, Andrea Tamayo, Mariel Pérez, David Dávila, Lotty Birnberg, Víctor Acuña Alonzo, Johannes Krause, Marcelo Grijalva
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in a total of 1101 Ecuadorian individuals from three regions of the country, the Coastal region, the Andean region, and the Amazonian region, to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent HLA haplotypes with significant linkage disequilibrium in those populations are HLA-A∗24∼B∗35∼DRB1∗04∼DQB1∗03:02, A∗02∼B∗35∼DRB1∗04∼DQB1∗03:02, A∗24∼B∗35∼DRB1∗14∼DQB1∗03:01, A∗02∼B∗35∼DRB1∗14∼DQB1∗03:01 and A∗02∼B∗40:02∼DRB1∗04∼DQB1∗03:02...
June 13, 2018: Human Immunology
https://www.readbyqxmd.com/read/29908208/nucleic-acids-binding-strategies-of-small-molecules-lessons-from-alkaloids
#11
Anirban Basu, Gopinatha Suresh Kumar
BACKGROUND: Nucleic acids are now important targets for therapeutic intervention. Alkaloids are an important class of molecules that have myriad therapeutic utility. Isoquinoline and benzophenanthridine alkaloids exhibit multiple pharmacological activities which are often related to their strong nucleic acid binding abilities. Therefore, a review of their interaction aspects with varying nucleic acid structures is essential for rational design and development as therapeutic agents. SCOPE OF THE REVIEW: This work reviews the interaction of various therapeutically important isoquinoline and benzophenanthridine alkaloids with nucleic acids...
June 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29908203/sirt2-reduces-actin-polymerization-and-cell-migration-through-deacetylation-and-degradation-of-hsp90
#12
Jung Sun Min, Jin Chul Kim, Ji Ae Kim, Inho Kang, Jeong Keun Ahn
SIRT2, a member of the class III histone deacetylase family, has been identified as a tumor suppressor, which is associated with various cellular processes including metabolism and proliferation. However, the effects of SIRT2 on cancer cell migration caused by cytoskeletal rearrangement remain uncertain. Here we show that SIRT2 inhibits cell motility by suppressing actin polymerization. SIRT2 regulates actin dynamics through HSP90 destabilization and subsequent repression of LIM kinase (LIMK) 1/cofilin pathway...
June 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29908188/a-computational-study-of-the-role-of-spatial-receptive-field-structure-in-processing-natural-and-non-natural-scenes
#13
Victor J Barranca, George Zhu
The center-surround receptive field structure, ubiquitous in the visual system, is hypothesized to be evolutionarily advantageous in image processing tasks. We address the potential functional benefits and shortcomings of spatial localization and center-surround antagonism in the context of an integrate-and-fire neuronal network model with image-based forcing. Utilizing the sparsity of natural scenes, we derive a compressive-sensing framework for input image reconstruction utilizing evoked neuronal firing rates...
June 13, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29908185/design-and-development-of-pegylated-liposomal-formulation-of-her2-blocker-lapatinib-for-enhanced-anticancer-activity-and-diminshed-cardiotoxicity
#14
Richa Shrivastava, Shruti Trivedi, Pankaj Kumar Singh, Mohammad Asif, Manish Kumar Chourasia, Amit Khanna, Smrati Bhadauria
Breast cancer is most frequently diagnosed cancer and fifth leading cause of death in women. About 20-30% of all breast cancers overexpress HER2/neu receptors. Lapatinib is a dual tyrosin kinase inhibitor of EGFR and HER2. It exhibits its anticancer effect via blocking intracellular domain of HER2 receptor in breast cancer. Lapatinib belongs to class II of BSC classification due to its poor solubility restricting its clinical application. Due to presence of HER2 receptor on cardiomyocytes, it is associated with generation of cardiotoxicity...
June 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29908151/vaccination-with-a-cd4-and-cd8-t-cell-epitopes-based-recombinant-chimeric-protein-derived-from-leishmania-infantum-proteins-confers-protective-immunity-against-visceral-leishmaniasis
#15
Daniel S Dias, Patrícia A F Ribeiro, Vívian T Martins, Daniela P Lage, Lourena E Costa, Miguel A Chávez-Fumagalli, Fernanda F Ramos, Thaís T O Santos, Fernanda Ludolf, Jamil S Oliveira, Tiago A O Mendes, Eduardo S Silva, Alexsandro S Galdino, Mariana C Duarte, Bruno M Roatt, Daniel Menezes-Souza, Antonio L Teixeira, Eduardo A F Coelho
Vaccination seems to be the best approach to control visceral leishmaniasis (VL). Resistance against infection is based on the development of a Th1 immune response characterized by the production of interferons-γ (IFN-γ), interleukin-12 (IL-12), granulocyte-macrophage-colony-stimulating factor (GM-CSF), and tumor necrosis factor-α (TNF-α), among others. A number of antigens have been tested as potential targets against the disease; few of them are able to stimulate human immune cells. In the present study, 1 prediction of MHC class I and II molecules-specific epitopes in the amino acid sequences of 3 Leishmania proteins: 1 hypothetical, prohibitin, and small glutamine-rich tetratricopeptide repeat-containing proteins, was performed using bioinformatics tools, and a T-cell epitopes-based recombinant chimeric protein was constructed, synthetized and purified to be evaluated in invitro and in vivo experiments...
May 22, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29908144/improving-the-quality-of-electroretinogram-recordings-using-active-electrodes
#16
Yolanda Wong Ying Yip, Tsz Chun Man, Chi Pui Pang, Mårten Erik Brelén
The aim of this study was to compare the quality of electroretinogram (ERG) recordings using a custom built active electrode with attached amplifier versus a standard (passive) ERG electrode. Scotopic and photopic ERG responses were recorded from five adult albino rabbits using a custom built active electrode on one eye and a passive electrode on the other. For the active electrode, the ERG-jet electrode (Universo S.A., La Chaux-De-Fonds, Switzerland) was used as the transducer with the cable cut short and soldered directly to the input of a customized amplifier...
June 13, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29908130/designed-macrocyclic-peptides-as-nanomolar-amyloid-inhibitors-based-on-minimal-recognition-elements
#17
Anna Spanopoulou, Luzia Heidrich, Hong-Ru Chen, Christina Frost, Dean Hrle, Eleni Malideli, Kathleen Hille, Alexandros Grammatikopoulos, Jürgen Bernhagen, Martin Zacharias, Gerhard Rammes, Aphrodite Kapurniotu
Amyloid self-assembly is linked to the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes (T2D), but so far none of the anti-amyloid molecules has reached the clinic. Macrocyclic peptides belong to the most attractive drug candidates. Here we present macrocyclic peptides (MCIPs) designed using minimal IAPP-derived recognition elements as a novel class of nanomolar amyloid inhibitors of both Abeta40(42) and IAPP or Abeta40(42) alone and show that chirality controls inhibitor selectivity. Sequence optimization led to the discovery of an Abeta40(42)-selective MCIP exhibiting high proteolytic stability in human plasma and human blood-brain-barrier (BBB) crossing ability in a cell model, two highly desirable properties for anti-amyloid drugs in AD...
June 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29908125/roles-of-the-nucleotide-exchange-factor-and-chaperone-hsp110-in-cellular-proteostasis-and-diseases-of-protein-misfolding
#18
Unekwu M Yakubu, Kevin A Morano
Cellular protein homeostasis (proteostasis) is maintained by a broad network of proteins involved in synthesis, folding, triage, repair and degradation. Chief among these are molecular chaperones and their cofactors that act as powerful protein remodelers. The growing realization that many human pathologies are fundamentally diseases of protein misfolding (proteopathies) has generated interest in understanding how the proteostasis network impacts onset and progression of these diseases. In this minireview, we highlight recent progress in understanding the enigmatic Hsp110 class of heat shock protein that acts as both a potent nucleotide exchange factor to regulate activity of the foldase Hsp70, and as a passive chaperone capable of recognizing and binding cellular substrates on its own, and its integration into the proteostasis network...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29908062/validation-of-the-acuros-xb-dose-calculation-algorithm-versus-monte-carlo-for-clinical-treatment-plans
#19
Lone Hoffmann, Markus Alber, Matthias Söhn, Ulrik Vindelev Elstrøm
PURPOSE: The two distinct dose computation paradigms of Boltzmann Equation Solvers and Monte Carlo simulation both promise in principle maximum accuracy. In practice, clinically acceptable calculation times demand approximations and numerical short-cuts on one hand, and modelling the beam characteristics of a real linear accelerator to the required accuracy on the other. A thorough benchmark of both algorithm types therefore needs to start with beam modelling, and needs to include a number of clinically challenging treatment plans...
June 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29908021/burnout-among-primary-school-teachers-in-iraq-prevalence-and-risk-factors
#20
Jasim Al-Asadi, Shukrya Khalaf, Aqeel Al-Waaly, Alaa Abed, Sabah Shami
Background: Studies from various parts of the world have shown that teachers are likely to suffer from burnout. So far, there has been no research on burnout among primary school teachers in Basrah, Iraq. Aim: We aimed to determine the prevalence and predisposing factors of self-reported burnout among primary school teachers in Basrah. Methods: This was a cross-sectional study in 32 governmental primary schools during November 2014-February 2015...
June 10, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
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