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vitamin K deficiency

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https://www.readbyqxmd.com/read/28346853/high-prevalence-of-vitamin-d-deficiency-and-correlation-of-serum-vitamin-d-with-cardiovascular-risk-in-patients-with-metabolic-syndrome
#1
Mohammad J Alkhatatbeh, Khalid K Abdul-Razzak, Lubna Q Khasawneh, Nesreen A Saadeh
BACKGROUND: Metabolic syndrome (MetS) identifies subjects with increased risk of cardiovascular disease when they have a combination of insulin resistance, obesity, hypertension, hyperglycemia, low high-density lipoprotein cholesterol (HDL-C), and elevated triglycerides (TGs). Increasing evidence suggests that vitamin D deficiency could be associated with diabetes and MetS. The aim is to assess if 25-hydroxyvitamin D (25-OHD) is correlated with cardiovascular risk components of MetS. METHODS: A cross-sectional study involved 124 diabetic patients with MetS according to International Diabetes Federation definition...
March 27, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28340119/the-risk-of-nephrolithiasis-is-causally-related-to-inactive-matrix-gla-protein-a-marker-of-vitamin-k-status-a-mendelian-randomization-study-in-a-flemish-population
#2
Fang-Fei Wei, Lutgarde Thijs, Zhen-Yu Zhang, Lotte Jacobs, Wen-Yi Yang, Erika Salvi, Lorena Citterio, Nicholas Cauwenberghs, Tatiana Kuznetsova, Nadja E A Drummen, Azusa Hara, Paolo Manunta, Yan Li, Peter Verhamme, Karel Allegaert, Daniele Cusi, Cees Vermeer, Jan A Staessen
Background.: Vitamin K (VK)-dependent γ-glutamate carboxylation and serine phosphorylation activate matrix Gla protein (MGP) to a potent locally acting inhibitor of calcification. Nephrolithiasis represents a process of unwanted calcification associated with substantial mortality and high recurrence rates. We hypothesized that the risk of nephrolithiasis increases with VK shortage, as exemplified by higher plasma levels of desphospho-uncarboxylated MGP (dp-ucMGP). Methods...
March 15, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28334845/infantile-tremor-syndrome-and-subdural-hemorrhage-in-an-infant-with-cystic-fibrosis
#3
Anirban Mandal, Mayank Priyadarshi, Kanaram Jat, Sushil Kumar Kabra
Cystic fibrosis (CF), an autosomal recessive disease with multi-system involvement, may present with bleeding in infancy owing to vitamin K malabsorption. Infantile tremor syndrome (ITS) is an obscure condition associated with vitamin B12 and other micronutrient deficiencies, described predominantly in Indian subcontinent. We describe an infant presenting with ITS and chronic subdural hemorrhage. He was subsequently diagnosed to have CF. The ITS and subdural hemorrhage is rarely reported in children with CF...
February 23, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28334220/effect-of-vitamin-d-deficiency-in-developed-countries
#4
Zaki K Hassan-Smith, Martin Hewison, Neil J Gittoes
Introduction: Vitamin D deficiency is common worldwide with adverse effects on skeletal health. In recent years, there has been great interest in non-classical actions of vitamin D. Basic research has uncovered actions in a range of non-skeletal tissues, and observational studies have identified inverse relationships with risk of a number of disease states including sarcopenia, obesity, the metabolic syndrome, cardiovascular disease, cancer and autoimmune diseases. Sources of data: PubMed, Medline and Cochrane Systematic Reviews...
March 9, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28327618/the-transcriptional-repressor-hic1-regulates-intestinal-immune-homeostasis
#5
K Burrows, F Antignano, M Bramhall, A Chenery, S Scheer, V Korinek, T M Underhill, C Zaph
The intestine is a unique immune environment that must respond to infectious organisms but remain tolerant to commensal microbes and food antigens. However, the molecular mechanisms that regulate immune cell function in the intestine remain unclear. Here we identify the POK/ZBTB family transcription factor hypermethylated in cancer 1 (HIC1, ZBTB29) as a central component of immunity and inflammation in the intestine. HIC1 is specifically expressed in immune cells in the intestinal lamina propria (LP) in the steady state and mice with a T-cell-specific deletion of HIC1 have reduced numbers of T cells in the LP...
March 22, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28321545/tissue-distribution-of-oral-vitamin-b12-is-influenced-by-b12-status-and-b12-form-an-experimental-study-in-rats
#6
Linda S Kornerup, Sergey N Fedosov, Christian B Juul, Eva Greibe, Christian W Heegaard, Ebba Nexo
PURPOSE: Hydroxocobalamin (HOCbl) is the dominating Cbl form in food, whereas cyanocobalamin (CNCbl) is common in vitamin pills and oral supplements. This study compares single-dose absorption and distribution of oral HO[(57)Co]Cbl and CN[(57)Co]Cbl in Cbl-deficient and normal rats. METHODS: Male Wistar rats (7 weeks) were fed a 14-day diet with (n = 15) or without (n = 15) Cbl. We compared the uptakes of HO[(57)Co]Cbl (free or bound to bovine transcobalamin) and free CN[(57)Co]Cbl administered by gastric gavage (n = 5 in each diet group)...
March 20, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28319421/detection-of-subclinical-vitamin-k-deficiency-in-neurosurgery-with-pivka-ii
#7
Sofia Dahlberg, Caroline Ulfsdotter Nilsson, Thomas Kander, Ulf Schött
Vitamin K is known for supporting the carboxylation of hepatic coagulation proteins. Levels of proteins induced by vitamin K absence for factor II (PIVKA-II) reflect hypocarboxylated prothrombin and can be used to detect subclinical vitamin K deficiency. The aim of this study was to determine the prevalence of perioperative subclinical vitamin K deficiency among neurosurgical patients using PIVKA-II and investigate the existence of any correlation to standard coagulation assays. Also, the antitumor effects of vitamin K were reviewed...
March 20, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28315864/vitamin-d-status-gender-differences-and-cardiometabolic-health-disparities
#8
Dharambir K Sanghera, Bishwa R Sapkota, Christopher E Aston, Piers R Blackett
BACKGROUND: Vitamin D deficiency is an unrecognized epidemic found in India and also worldwide. Despite the high prevalence of diabetes among Indians, there is a paucity of data showing the relationship between vitamin D status and cardiometabolic disparities. In this study, we have examined the relationship between vitamin D and cardiometabolic traits in a population from India. METHODS: Circulating 25(OH)D levels were measured in 3,879 participants from the Asian Indian Diabetic Heart Study using ELISA kits...
March 18, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28303703/assessment-of-dietary-choices-of-young-women-in-the-contexts-of-hormonal-contraceptives
#9
Mariola Friedrich, Magdalena Junak
Background: Metabolic changes caused by hormonal contraception combined with unbalanced diet may pose many threats, and deficiency or excess of nutrients may increase the risk of using such contraceptives. Objective: The purpose of the survey was to assess the dietary choices of young women using hormonal contraceptives, taking into account their general knowledge about the contraception and its impact on their bodies. Material and methods: The survey comprised 67 women aged from 18 to 25 years...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28286773/the-strategy-to-prevent-and-regress-the-vascular-calcification-in-dialysis-patients
#10
REVIEW
Nai-Ching Chen, Chih-Yang Hsu, Chien-Liang Chen
The high prevalence of arterial calcification in end-stage renal disease (ESRD) is far beyond the explanation by common cardiovascular risk factors such as aging, diabetes, hypertension, and dyslipidemia. The finding relies on the fact that vascular and valvular calcifications are predictors of cardiovascular diseases and mortality in persons with chronic renal failure. In addition to traditional cardiovascular risk factors such as diabetes mellitus and blood pressure control, other ESRD-related risks such as phosphate retention, excess calcium, and prolonged dialysis time also contribute to the development of vascular calcification...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28285298/is-vitamin-d-deficiency-linked-to-critical-illness-authors-reply
#11
Satish K Shah, Rakesh Lodha
No abstract text is available yet for this article.
February 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28281786/susceptiveness-of-vitamin-k-epoxide-reductase-complex-subunit-1-gene-polymorphism-in-essential-hypertension
#12
Didem Turgut Cosan, Huseyin Ugur Yazıcı, Emine Colak, Ahu Soyocak, Irfan Degirmenci, Hulyam Kurt, Alparslan Birdane, Ertugrul Colak, Hasan Veysi Gunes
BACKGROUND: Essential hypertension (EH) is defined as worldwide public health problem and one of the important risk factors for development of human coronary artery disease. Increased peripheral arterial resistance is one of the distinguishing characteristics of EH. The extracellular deposition of calcium in the arterial wall is defined as vascular calcification, which results in aortic stiffness and elevation of blood pressure. Regulation of vascular calcification is physiologically limited by γ-carboxylated proteins that regulate mineralization...
March 10, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28281092/effectiveness-of-prothrombin-complex-concentrate-pcc-in-neonates-and-infants-with-bleeding-or-risk-of-bleeding-a-systematic-review-and-meta-analysis
#13
Linan Zeng, Imti Choonara, Lingli Zhang, Youping Li, Jing Shi
To systematically evaluate the effectiveness of prothrombin complex concentrate (PCC) in neonates and infants, we performed a systematic review and meta-analysis based on current evidence. Quality of studies was assessed by Cochrane Collaboration's risk of bias tool and Newcastle-Ottawa quality assessment scale. For dichotomous data, we obtained the number of events and total number and calculated the relative risk (RR) with 95% confidence intervals (CI). For continuous variables, we obtained mean and standard deviation (SD) values and calculated mean difference (MD) with 95% CI...
March 9, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28280644/vitamin-k-deficiency-presenting-in-an-infant-with-an-anterior-mediastinal-mass-a-case-report-and-review-of-the-literature
#14
Mauricio A Palau, Amanda Winters, Xiayuan Liang, Rachelle Nuss, Susan Niermeyer, Megan Gossling, Clyde Wright
We report a case of a 1-month-old infant with spontaneous thymic hemorrhage secondary to severe vitamin K deficiency. He was brought to medical attention due to scrotal bruising and during evaluation was noted to be tachypneic and hypoxemic. Chest X-ray revealed an enlarged cardiothymic silhouette, and a follow-up echocardiogram revealed a mass in the anterior mediastinum. Routine laboratory work-up revealed severe coagulopathy. Further questioning revealed the patient had not received prophylactic vitamin K at birth...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28277269/refusal-of-vitamin-k-by-parents-of-newborns-a-survey-of-the-better-outcomes-through-research-for-newborns-network
#15
Jaspreet Loyal, James A Taylor, Carrie A Phillipi, Neera K Goyal, Niramol Dhepyasuwan, Eugene D Shapiro, Eve Colson
OBJECTIVE: To survey newborn clinicians in the United States regarding the frequency of intramuscular (IM) vitamin K refusal by a parent, reasons for refusal, and approaches of clinicians to refusals. METHODS: An electronic survey was administered to the clinician site representative (nursery director or designee knowledgeable about site-specific nursery policies) at all newborn nurseries in the Better Outcomes through Research for Newborns (BORN) network of newborn nurseries...
March 9, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28271675/vitamin-d-deficiency-and-a-blunted-parathyroid-hormone-response-in-children-with-attention-deficit-hyperactivity-disorder
#16
Sibelnur Avcil, Pinar Uysal, Mustafa Yilmaz, Duygu Erge, Sevcan K Demirkaya, Esra Eren
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is the most frequently diagnosed neuropsychiatric disorder of childhood. The etiopathogenesis of ADHD has not been fully defined. Recent evidence has suggested a pathophysiological role of vitamin D deficiency in ADHD. In this study, we evaluated the serum levels of 25-hydroxy vitamin D (25(OH)D), parathyroid hormone (PTH), calcium (Ca), phosphate (P), and alkaline phosphatase (ALP) in children with ADHD. METHODS: The study group consisted of 105 children diagnosed with ADHD according to DSM-IV-TR criteria...
March 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28261096/antioxidant-activities-metabolic-profiling-proximate-analysis-mineral-nutrient-composition-of-salvadora-persica-fruit-unravel-a-potential-functional-food-and-a-natural-source-of-pharmaceuticals
#17
Asha Kumari, Asish K Parida, Jaykumar Rangani, Ashok Panda
Salvadora persica is a medicinally important plant mainly used in oral hygiene. However, little attention has been given towards the nutritional prominence of this plant. This study encloses the proximate and mineral nutrient contents, amino acid composition, metabolite profiling and antioxidant potential of S. persica fruit. The ripen fruit contained substantial amount of sugars, mineral nutrients, carotenoids, polyphenols and flavonoids. The metabolic profiling of the fruit extract by GC-MS revealed a total of 22 metabolites comprising of sugars, sugar alcohols, organic acids, organic base, and aromatic silica compound...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28259214/vitamin-d-deficiency-in-adult-sickle-cell-patients
#18
Peter C Boettger, Charles L Knupp, Darla K Liles, Kaitlyn Walker
INTRODUCTION: Vitamin D levels in adult black Americans with sickle cell disease (SCD) are comparatively lower than those found in the general population of black Americans. The objectives of this study were to examine the prevalence of Vitamin D deficiency (VDD) in adults with various subtypes of sickle cell disease and identify risk factors for vitamin D deficiency. METHODS: In a retrospective study serum Vitamin D25(OH)D and/or VitaminD1,25(OH)2D levels were obtained in 120 subjects with sickle cell disease...
April 2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/28255653/season-dietary-factors-and-physical-activity-modify-25-hydroxyvitamin-d-concentration-during-pregnancy
#19
Helena H Hauta-Alus, Elisa M Holmlund-Suila, Hannu J Rita, Maria Enlund-Cerullo, Jenni Rosendahl, Saara M Valkama, Otto M Helve, Timo K Hytinantti, Heljä-Marja Surcel, Outi M Mäkitie, Sture Andersson, Heli T Viljakainen
PURPOSE: The objectives of this cross-sectional study were to define maternal and umbilical cord blood (UCB) 25-hydroxyvitamin D (25(OH)D) to characterize maternal factors modifying 25(OH)D during pregnancy and predict UCB 25(OH)D in two subgroups with Declined [Δ25(OH)D <0 nmol/l] and Increased [Δ25(OH)D >0 nmol/l] 25(OH)D concentration. METHODS: A complete dataset was available from 584 women. 25(OH)D was determined at gestational weeks 6-13 and in UCB...
March 2, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28248532/trace-elements-have-beneficial-as-well-as-detrimental-effects-on-bone-homeostasis
#20
I Zofkova, M Davis, J Blahos
The protective role of nutrition factors such as calcium, vitamin D and vitamin K for the integrity of the skeleton is well understood. In addition, integrity of the skeleton is positively influenced by certain trace elements (e.g. zinc, copper, manganese, magnesium, iron, selenium, boron and fluoride) and negatively by others (lead, cadmium, cobalt). Deficiency or excess of these elements influence bone mass and bone quality in adulthood as well as in childhood and adolescence. However, some protective elements may become toxic under certain conditions, depending on dosage (serum concentration), duration of treatment and interactions among individual elements...
February 28, 2017: Physiological Research
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