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Benseler and elbers

Jorina Elbers, Derek Armstrong, Susanne M Benseler, Nomazulu Dlamini, Gary K Steinberg, Kristen W Yeom
BACKGROUND: Intracranial arteriopathies are frequent causes of pediatric stroke and important risk factors for stroke recurrence. Without tissue diagnosis, vascular imaging is relied upon to identify the underlying etiology and prognosis. We hypothesized that children with unilateral intracranial arteriopathy with lenticulostriate collaterals would demonstrate distinct vascular outcomes compared with children without collaterals. METHODS: We retrospectively identified children with unilateral intracranial arteriopathy from two institutions...
January 2018: Pediatric Neurology
Jorina Elbers, Derek Armstrong, Ivanna Yau, Susanne Benseler
BACKGROUND: Inflammation affecting cerebral blood vessels is a common cause of stroke in children. Arterial abnormalities on vascular imaging are an important risk factor for stroke recurrence. We aimed to describe the vascular imaging outcomes in children with primary angiitis of the central nervous system after 12 months and identify factors associated with vascular progression and stroke recurrence. METHODS: We retrospectively analyzed clinical and neuroimaging data from the BrainWorks Registry of children with large-vessel primary angiitis of the central nervous system...
October 2016: Pediatric Neurology
Jorina Elbers, William Halliday, Cynthia Hawkins, Clare Hutchinson, Susanne M Benseler
OBJECTIVE: Primary angiitis of the central nervous system in childhood (cPACNS) is an immune-mediated inflammatory process directed toward blood vessels in the central nervous system. It has been associated with variable clinical and radiological presentations, and devastating consequences without treatment. Brain biopsy is required for definitive diagnosis. The objective of this study was to characterize the clinical and histopathological features of brain biopsies in small-vessel cPACNS (SVcPACNS)...
November 2010: Annals of Neurology
Clare Hutchinson, Jorina Elbers, William Halliday, Helen Branson, Suzanne Laughlin, Derek Armstrong, Cynthia Hawkins, Robyn Westmacott, Susanne M Benseler
BACKGROUND: There is no treatment protocol or standardised documentation of neurological outcome for patients with small vessel childhood primary angiitis of the CNS, a rare inflammatory brain disease. We aimed to assess a treatment regimen and describe long-term neurological outcomes in a cohort of children with this disorder. METHODS: We did a single-centre open-label cohort study in children with small vessel childhood primary angiitis of the CNS who were less than 18 years old at diagnosis...
November 2010: Lancet Neurology
Jorina Elbers, Susanne M Benseler
PURPOSE OF REVIEW: To review the current literature of primary and secondary central nervous system vasculitis in children, to evaluate the evolving classification and to suggest an approach to diagnosis. RECENT FINDINGS: Central nervous system vasculitis in children is a newly recognized inflammatory brain disease, which may develop as a primary condition, or secondary to an underlying systemic disease. Primary angiitis of the central nervous system of childhood (cPACNS) is a reversible cause of severe neurological impairment, including acute ischemic stroke, intractable seizures and cognitive decline...
January 2008: Current Opinion in Rheumatology
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