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JOURNAL ARTICLE
Tobias Bensel, Simon Megiroo, Werner Kronenberg, Wolfgang Bömicke, Timo Ulrichs, Sebastian Hinz
The challenge of reduced dental treatment and education infrastructure in the Tanzanian highlands affects the oral health situation of both the general population and local healthcare workers. The aim of this study was to investigate the oral health status of healthcare workers at Ilembula Lutheran Hospital (ILH), Tanzania, during the COVID-19 pandemic. In total, 134 healthcare workers (62 women, 72 men; mean age 36.48 ± 9.56 years, range 19-59 years; median age 35.00 years) participated in this cross-sectional study, conducted from 12 February to 27 February...
April 29, 2024: Healthcare (Basel, Switzerland)
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JOURNAL ARTICLE
Anna A Florax, Martijn J H Doeleman, Sytze de Roock, Naomi van der Linden, Ellen Schatorjé, Gillian Currie, Deborah A Marshall, Maarten J IJzerman, Rae S M Yeung, Susanne M Benseler, Sebastiaan J Vastert, Nico M Wulffraat, Joost F Swart, Michelle M A Kip
OBJECTIVE: To quantify differences in hospital-associated costs, and accompanying travel costs and productivity losses, before and after withdrawing TNFi in JIA patients. METHODS: Retrospective analysis of prospectively collected data from electronic medical records of paediatric JIA patients treated with TNFi, which were either immediately discontinued, spaced (increased treatment interval) or tapered (reduced subsequent doses). Costs of hospital-associated resource use (consultations, medication, radiology procedures, laboratory testing, procedures under general anaesthesia, hospitalisation) and associated travel costs and productivity losses were quantified during clinically inactive disease until TNFi withdrawal (pre-withdrawal period) and compared with costs during the first and second year after withdrawal initiation (first and second year post-withdrawal)...
December 20, 2023: Rheumatology
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JOURNAL ARTICLE
Han Chen, Mehar Monga, Qinghua Fang, Loujin Slitin, Jakob Neef, Shashank S Chepurwar, Regina Célia Mingroni Netto, Karina Lezirovitz, Alfredo Tabith, Fritz Benseler, Nils Brose, Kathrin Kusch, Carolin Wichmann, Nicola Strenzke, Barbara Vona, Julia Preobraschenski, Tobias Moser
No abstract text is available yet for this article.
December 8, 2023: Protein & Cell
#4
JOURNAL ARTICLE
Kelly Nguyen, Julie Barsalou, Daniah Basodan, Michelle Batthish, Susanne M Benseler, Roberta A Berard, Nicholas Blanchette, Gilles Boire, Roxana Bolaria, Alessandra Bruns, David A Cabral, Bonnie Cameron, Sarah Campillo, Tania Cellucci, Mercedes Chan, Gaëlle Chédeville, Anne-Laure Chetaille, Amieleena Chhabra, Julie Couture, Paul Dancey, Jean-Jacques De Bruycker, Erkan Demirkaya, Muhammed Dhalla, Ciarán M Duffy, Brian M Feldman, Debbie E Feldman, Tommy Gerschman, Elie Haddad, Liane Heale, Julie Herrington, Kristin Houghton, Adam M Huber, Andrea Human, Nicole Johnson, Roman Jurencak, Bianca Lang, Maggie Larché, Ronald M Laxer, Claire M LeBlanc, Jennifer J Y Lee, Deborah M Levy, Lillian Lim, Lily S H Lim, Nadia Luca, Tara McGrath, Tamara McMillan, Paivi M Miettunen, Kimberly A Morishita, Hon Yan Ng, Kiem Oen, Jonathan Park, Ross E Petty, Jean-Philippe Proulx-Gauthier, Suzanne Ramsey, Johannes Roth, Alan M Rosenberg, Evelyn Rozenblyum, Dax G Rumsey, Heinrike Schmeling, Rayfel Schneider, Rosie Scuccimarri, Natalie J Shiff, Earl Silverman, Gordon Soon, Lynn Spiegel, Elizabeth Stringer, Herman Tam, Shirley M Tse, Lori Tucker, Stuart Turvey, Marinka Twilt, Karen Watanabe Duffy, Rae S M Yeung, Jaime Guzman
OBJECTIVE: To assess changes in juvenile idiopathic arthritis (JIA) treatments and outcomes in Canada, comparing a 2005-2010 and a 2017-2021 inception cohorts. METHODS: Patients enrolled within three months of diagnosis in the Research in Arthritis in Canadian Children Emphasizing Outcomes (ReACCh-Out) and the Canadian Alliance of Pediatric Rheumatology Investigators Registry (CAPRI) cohorts were included. Cumulative incidences of drug starts and outcome attainment within 70 weeks of diagnosis were compared with Kaplan Meier survival analysis and multivariable Cox regression...
October 18, 2023: Rheumatology
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JOURNAL ARTICLE
G R Currie, B L Kennedy, Benseler S M, Yeung R S M, Swart J F, Vastert S J, Wulffraat N M, Kip M M A, Gail MacKean, D A Marshall
INTRODUCTION: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and causes short- and long-term disability. Optimal management requires pharmacologic and non-pharmacologic interventions. Few studies have explored the youth and family experience of the management of JIA. This study's objective was to explore the management experience of youth with JIA and their parents. METHODS: This qualitative study used semi-structured interviews with youth 12-18 years of age with JIA receiving biological medication and parents of children with JIA on biological medication...
August 19, 2023: Musculoskeletal Care
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JOURNAL ARTICLE
Severin Rodler, Karl-Friedrich Kowalewski, Henriette Scheibert, Moritz Bensel, Leo Federico Stadelmeier, Amelie Styn, Ines Rivero Belenchon, Mark Taratkin, Stefano Puliatti, Juan Gomez Rivas, Alessandro Veccia, Pietro Piazza, Enrico Checcucci, Maurice S Michel, Christian G Stief, Giovanni Cacciamani
UNLABELLED: Digital therapeutics (DTx) are a new class of intervention involving evidence-based software applications and have been used in neurology and psychiatry. To assess the potential of DTx in urology, we conducted a survey to assess the current prevalence of the digital infrastructure required for DTx, areas of support expected by patients, and requirements for uptake. Between November 2022 and January 2023, we conducted an anonymized survey at two German academic centers among patients with urologic conditions...
September 2023: European urology open science
#7
JOURNAL ARTICLE
Janine A van Til, Michelle M A Kip, Ellen J H Schatorjé, Gillian Currie, Marinka Twilt, Susanne M Benseler, Joost F Swart, Sebastiaan J Vastert, Nico Wulffraat, Rae S M Yeung, C G M Karin Groothuis-Oudshoorn, Sanne Warta, Deborah A Marshall, Maarten J IJzerman
OBJECTIVE: Approximately one third of children with JIA receive biologic therapy, but evidence on biologic therapy withdrawal is lacking. This study aims to increase our understanding of whether and when pediatric rheumatologists postpone a decision to withdraw biologic therapy in children with clinically inactive non-systemic JIA. METHODS: A survey containing questions about background characteristics, treatment patterns, minimum treatment time with biologic therapy, and 16 different patient vignettes, was distributed among 83 pediatric rheumatologists in Canada and the Netherlands...
July 11, 2023: Pediatric Rheumatology Online Journal
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JOURNAL ARTICLE
Tala El Tal, Marie-Paule Morin, Shaun K Morris, Daniel S Farrar, Roberta A Berard, Fatima Kakkar, Charlotte Moore Hepburn, Krista Baerg, Camille Beaufils, Terri-Lyn Bennett, Susanne M Benseler, Guillaume Beaudoin-Bussières, Kevin Chan, Claude Cyr, Nagib Dahdah, Elizabeth J Donner, Olivier Drouin, Rojiemiahd Edjoc, Maryem Eljaouhari, Joanne E Embree, Catherine Farrell, Andrés Finzi, Sarah Forgie, Ryan Giroux, Kristopher T Kang, Melanie King, Melanie Laffin Thibodeau, Bianca Lang, Ronald M Laxer, Thuy Mai Luu, Brian W McCrindle, Julia Orkin, Jesse Papenburg, Catherine M Pound, Victoria E Price, Jean-Philippe Proulx-Gauthier, Rupeena Purewal, Manish Sadarangani, Marina I Salvadori, Roseline Thibeault, Karina A Top, Isabelle Viel-Thériault, Elie Haddad, Rosie Scuccimarri, Rae S M Yeung
BACKGROUND: Paediatric inflammatory multisystem syndrome (PIMS) is a rare condition temporally associated with SARS-CoV-2 infection. Using national surveillance data, we compare presenting features and outcomes among children hospitalized with PIMS by SARS-CoV-2 linkage, and identify risk factors for intensive care (ICU). METHODS: Cases were reported to the Canadian Paediatric Surveillance Program by a network of >2800 pediatricians between March 2020 and May 2021...
June 5, 2023: Pediatric Research
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JOURNAL ARTICLE
V Shashi, K Schoch, R Ganetzky, P G Kranz, N Sondheimer, M L Markert, H Cope, A Sadeghpour, P Roehrs, T Arbogast, C Muraresku, A V Tyndall, M J Esser, K E Woodward, B P Y Au, J S Parboosingh, R E Lamont, F P Bernier, N A M Wright, S M Benseler, S J Parsons, M El-Dairi, E C Smith, P Valdez, M Tennison, A M Innes, E E Davis
PURPOSE: Mendelian etiologies for acute encephalopathies in previously healthy children are poorly understood, with the exception of RAN Binding Protein 2 (RANBP2) associated Acute Necrotizing Encephalopathy sub-type 1 (ANE1). We provide clinical, genetic and neuroradiological evidence that biallelic variants in ribonuclease inhibitor (RNH1) confer susceptibility to a distinctive ANE subtype. METHODS: Evaluation of clinical data, neuroradiological studies, genomic sequencing and protein immunoblotting results in eight children from four families who experienced acute febrile encephalopathy...
May 13, 2023: Genetics in Medicine: Official Journal of the American College of Medical Genetics
#10
JOURNAL ARTICLE
Gillian R Currie, Brittany Gerber, Diane Lorenzetti, Karen MacDonald, Susanne M Benseler, Francois P Bernier, Kym M Boycott, K Vanessa Carias, Bettina Hamelin, Robin Z Hayeems, Claire LeBlanc, Marinka Twilt, Gijs van Rooijen, Durhane Wong-Rieger, Rae S M Yeung, Deborah A Marshall
BACKGROUND AND OBJECTIVE: Rare diseases place a significant burden on patients, families, the healthcare system, and society. Evidence on the socioeconomic burden of rare disease is limited and mostly reflects diseases where treatments are available. We developed a framework encompassing recommended cost elements for studies of the socioeconomic burden of rare diseases. METHODS: A scoping review, conducted in five databases (Cochrane Library, EconLit, Embase, MEDLINE, and APA PsycINFO), identified English language publications from 2000 to 2021 presenting frameworks developed for determining, measuring or valuing costs for rare or chronic diseases...
April 7, 2023: PharmacoEconomics
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JOURNAL ARTICLE
Brandon M Bensel, Samantha B Previs, Carol S Bookwalter, Sam Walcott, Kathleen M Trybus, David M Warshaw
No abstract text is available yet for this article.
February 10, 2023: Biophysical Journal
#12
JOURNAL ARTICLE
Luiza R Grazziotin, Gillian Currie, Marinka Twilt, Maarten J IJzerman, Michelle M A Kip, Hendrik Koffijberg, Gouke Bonsel, Susanne M Benseler, Joost F Swart, Sebastiaan J Vastert, Nico M Wulffraat, Rae S M Yeung, Wineke Armbrust, J Merlijn van den Berg, Deborah A Marshall
OBJECTIVE: This study investigates the relationship of child, caregiver, and caring context measurements with the care-related quality of life (CRQoL) and health-related quality of life (HRQoL) of caregivers of children with juvenile idiopathic arthritis (JIA). METHODS: We performed a cross-sectional analysis of baseline data on caregivers of children with JIA from Canada and the Netherlands collected for the "Canada-Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic Diseases" study from June 2019 to September 2021...
July 23, 2022: Pediatric Rheumatology Online Journal
#13
JOURNAL ARTICLE
Micol Romano, Z Serap Arici, David Piskin, Sara Alehashemi, Daniel Aletaha, Karyl S Barron, Susanne Benseler, Roberta Berard, Lori Broderick, Fatma Dedeoglu, Michelle Diebold, Karen L Durrant, Polly Ferguson, Dirk Foell, Jonathan Hausmann, Olcay Y Jones, Daniel L Kastner, Helen J Lachmann, Ronald M Laxer, Dorelia Rivera, Nicolino Ruperto, Anna Simon, Marinka Twilt, Joost Frenkel, Hal Hoffman, Adriana A de Jesus, Jasmin Beate Kuemmerle-Deschner, Seza Ozen, Marco Gattorno, Raphaela Goldbach-Mansky, Erkan Demirkaya
BACKGROUND: The interleukin-1 (IL-1) mediated systemic autoinflammatory diseases, including the cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor receptor-associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD) and deficiency of the IL-1 receptor antagonist (DIRA), belong to a group of rare immunodysregulatory diseases that primarily present in early childhood with variable multiorgan involvement. When untreated, patients with severe clinical phenotypes have a poor prognosis, and diagnosis and management of these patients can be challenging...
July 2022: Annals of the Rheumatic Diseases
#14
JOURNAL ARTICLE
Micol Romano, Z Serap Arici, David Piskin, Sara Alehashemi, Daniel Aletaha, Karyl Barron, Susanne Benseler, Roberta A Berard, Lori Broderick, Fatma Dedeoglu, Michelle Diebold, Karen Durrant, Polly Ferguson, Dirk Foell, Jonathan S Hausmann, Olcay Y Jones, Daniel Kastner, Helen J Lachmann, Ronald M Laxer, Dorelia Rivera, Nicola Ruperto, Anna Simon, Marinka Twilt, Joost Frenkel, Hal M Hoffman, Adriana A de Jesus, Jasmin B Kuemmerle-Deschner, Seza Ozen, Marco Gattorno, Raphaela Goldbach-Mansky, Erkan Demirkaya
BACKGROUND: The interleukin-1 (IL-1) mediated systemic autoinflammatory diseases, including the cryopyrin- associated periodic syndromes (CAPS), tumour necrosis factor receptor-associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD) and deficiency of the IL-1 receptor antagonist (DIRA), belong to a group of rare immunodysregulatory diseases that primarily present in early childhood with variable multiorgan involvement. When untreated, patients with severe clinical phenotypes have a poor prognosis, and diagnosis and management of these patients can be challenging...
July 2022: Arthritis & Rheumatology
#15
JOURNAL ARTICLE
Michelle M A Kip, Sytze de Roock, Gillian Currie, Deborah A Marshall, Luiza R Grazziotin, Marinka Twilt, Rae S M Yeung, Susanne M Benseler, Sebastiaan J Vastert, Nico Wulffraat, Joost F Swart, Maarten J IJzerman
OBJECTIVE: To investigate medication prescription patterns among children with juvenile idiopathic arthritis (JIA), including duration, sequence and reasons for medication discontinuation. METHODS: This study is a single-center, retrospective analysis of prospective data from electronic medical records of JIA patients receiving systemic therapy aged 0-18 years between 1 April 2011 and 31 March 2019. Patient characteristics (age, gender, JIA subtype) and medication prescriptions were extracted and analyzed using descriptive statistics, Sankey diagrams, and Kaplan-Meier survival methods...
May 18, 2022: Rheumatology
#16
JOURNAL ARTICLE
Luiza R Grazziotin, Gillian Currie, Marinka Twilt, Maarten J Ijzerman, Michelle M A Kip, Hendrik Koffijberg, Susanne M Benseler, Joost F Swart, Sebastiaan J Vastert, Nico M Wulffraat, Rae S M Yeung, Deborah A Marshall
OBJECTIVE: Pharmacological treatment is a cornerstone of care for children with juvenile idiopathic arthritis (JIA). The objective of this study is to evaluate prescription patterns of conventional and biologic disease modifying anti-rheumatic drugs (c-DMARDs and b-DMARDs) for patients with JIA. METHODS: We conducted a retrospective cohort study of children diagnosed with JIA at a rheumatology pediatric clinic. Eligibility criteria were defined as children and youth newly diagnosed with enthesis-related arthritis, polyarticular, or oligoarticular JIA between 2011 and 2019, with at least one year of observation...
April 11, 2022: Pediatric Rheumatology Online Journal
#17
JOURNAL ARTICLE
Audrea Chen, Cherry Mammen, Jaime Guzman, Eslam Al-Abadi, Susanne M Benseler, Roberta A Berard, Dana Gerstbacher, Merav Heshin-Bekenstein, Susan Kim, Marisa Klein-Gitelman, Pallavi Pimpale Chavan, Karen E James, Neil Martin, Flora McErlane, Charlotte Myrup, Damien G Noone, Jyothi Raghuram, Susan Shenoi, Vidya Sivaraman, Tamara Tanner, Rae S M Yeung, David A Cabral, Kimberly A Morishita
OBJECTIVES: High-dose glucocorticoids for remission-induction of ANCA-associated vasculitis are recommended and commonly used in adults, but recent studies suggest lower glucocorticoid doses can reduce toxicity without reducing efficacy. No paediatric-specific data exists to inform optimal glucocorticoid dosing in paediatric ANCA-associated vasculitis (pAAV). Our objectives were to describe glucocorticoid use in pAAV-related renal disease, and to explore associations between glucocorticoid dose, baseline patient characteristics and 12-month outcomes...
May 2022: Clinical and Experimental Rheumatology
#18
REVIEW
Gillian R Currie, Tram Pham, Marinka Twilt, Maarten J IJzerman, Pauline M Hull, Michelle M A Kip, Susanne M Benseler, Glen S Hazlewood, Rae S M Yeung, Nico M Wulffraat, Joost F Swart, Sebastian J Vastert, Deborah A Marshall
BACKGROUND: Few studies have examined pediatric rheumatologists' approaches to treatment decision making for biologic therapy for patients with juvenile idiopathic arthritis (JIA). This study presents the qualitative research undertaken to support the development of a Best-Worst Scaling (BWS) survey for tapering in JIA. The study objectives were to (1) describe the treatment decision-making process of pediatric rheumatologists to initiate and taper biologics; and (2) select attributes for a BWS survey...
September 2022: Patient
#19
JOURNAL ARTICLE
Aditi Banerjee, Cordelia Imig, Karthik Balakrishnan, Lauren Kershberg, Noa Lipstein, Riikka-Liisa Uronen, Jiexin Wang, Xintong Cai, Fritz Benseler, Jeong Seop Rhee, Benjamin H Cooper, Changliang Liu, Sonja M Wojcik, Nils Brose, Pascal S Kaeser
Despite the importance of dopamine for striatal circuit function, mechanistic understanding of dopamine transmission remains incomplete. We recently showed that dopamine secretion relies on the presynaptic scaffolding protein RIM, indicating that it occurs at active zone-like sites similar to classical synaptic vesicle exocytosis. Here, we establish using a systematic gene knockout approach that Munc13 and Liprin-α, active zone proteins for vesicle priming and release site organization, are important for dopamine secretion...
January 19, 2022: Neuron
#20
JOURNAL ARTICLE
Luiza R Grazziotin, Gillian Currie, Marinka Twilt, Maarten J Ijzerman, Michelle M A Kip, Hendrik Koffijberg, Susanne M Benseler, Joost F Swart, Sebastiaan J Vastert, Nico M Wulffraat, Rae S M Yeung, Nicole Johnson, Nadia J Luca, Paivi M Miettunen, Heinrike Schmeling, Deborah A Marshall
INTRODUCTION: Juvenile idiopathic arthritis (JIA) is a chronic rheumatic disease, whose multifaceted care path can lead to significant expenditure for the healthcare system. We aim to assess the real-world healthcare resource use (HCRU) and associated cost for children with JIA in a single center in Canada. METHODS: A single-center consecutive cohort of newly diagnosed patients with JIA attending the pediatric rheumatology clinic from 2011 to 2019 was identified using an administrative data algorithm and electronic medical charts...
July 18, 2021: Rheumatology and Therapy
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