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Benseler, sm

Rachana P Hasija, Earl D Silverman, Stephanie Cho, Lillia Fung, Susanne M Benseler, Bonnie Cameron, Brian M Feldman, Ronald M Laxer, Deborah M Levy, Rayfel Schneider, Lynn R Spiegel, Rae Sm Yeung, Michelle Anderson, Audrey Bell-Peter, Holly Convery, Karen Queffelec, Megan Saunders, Shirley Ml Tse
BACKGROUND/PURPOSE: Biologic therapies have revolutionized the management of rheumatic diseases of childhood. However, these medications are associated with adverse effects including the possible development of neoplasms. The aim of our study was to determine the rate as well as risk factors for the development of neoplasms in patients with JIA treated with biologics. METHODS: We performed a retrospective review of the rheumatology biologic registry (RBR) at The Hospital for Sick Children (SickKids), Toronto, Canada, one of the largest quarternary pediatric referral centres in North America...
March 2014: Arthritis & Rheumatology
L H Verhey, H M Branson, S Laughlin, M M Shroff, S M Benseler, B M Feldman, D L Streiner, J G Sled, B Banwell
BACKGROUND AND PURPOSE: The degree to which MR imaging is useful in the diagnosis of MS is predicated on standardized and reliable evaluation of MR imaging parameters. We aimed to devise items for an MR imaging scoring tool that would have high inter-rater agreement and would be straightforward to apply. MATERIALS AND METHODS: On the basis of a literature search and consensus of an expert panel, we identified 48 parameters that describe acute CNS demyelination, predict MS diagnosis, or characterize demyelinating disorder mimics...
June 2013: AJNR. American Journal of Neuroradiology
Jasmin B Kuemmerle-Deschner, Sm Benseler
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children and an important cause of short-term and long-term disability. Gene changes in the immune system can predispose to JIA and regulation of the immune system is crucial in the pathogenesis. The goal of therapy is complete disease control using disease-modifying antirheumatic drugs (DMARDS). Activated T-cells may play a role in the immunopathology of JIA. Therefore, targeting T-cell activation is a rational approach for the treatment of JIA...
December 2008: Biologics: Targets & Therapy
Roman Jurencák, Marvin Fritzler, Pascal Tyrrell, Linda Hiraki, Susanne Benseler, Earl Silverman
OBJECTIVE: (1) To evaluate the spectrum of serum autoantibodies in pediatric-onset systemic lupus erythematosus (pSLE) with a focus on ethnic differences; (2) using cluster analysis, to identify patients with similar autoantibody patterns and to determine their clinical associations. METHODS: A single-center cohort study of all patients with newly diagnosed pSLE seen over an 8-year period was performed. Ethnicity, clinical, and serological data were prospectively collected from 156/169 patients (92%)...
February 2009: Journal of Rheumatology
J Feuerstein, J C Bensel
No abstract text is available yet for this article.
July 1974: Revue D'électroencéphalographie et de Neurophysiologie Clinique
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