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https://www.readbyqxmd.com/read/29348811/disconnecting-the-estrogen-receptor-binding-properties-and-antimicrobial-properties-of-parabens-through-3-5-substitution
#1
Bridget L Bergquist, Kaelyn G Jefferson, Hailey N Kintz, Amorette E Barber, Andrew A Yeagley
Commercially utilized parabens are employed for their antimicrobial properties, but a weak binding to the estrogen receptor alpha (ERα) may lead to breast cancer in some applications. Modification of the paraben scaffold should allow for a disconnection of these observed properties. Toward this goal, various 3,5-substituted parabens were synthesized and assessed for antimicrobial properties against S. aureus as well as competitive binding to the ERα. The minimum inhibitory concentration assay confirmed retention of antimicrobial activity in many of these derivatives, while all compounds exhibited decreased xenoestrogen activity as determined by a combination of competitive enzyme linked immunosorbent assay (ELISA), proliferation, and estrogen receptor binding assay...
January 11, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29324270/agcl-ag3po4-a-stable-ag-based-nanocomposite-photocatalyst-with-enhanced-photocatalytic-activity-for-the-degradation-of-parabens
#2
Jianhao Guo, Huixian Shi, Xiaobo Huang, Huifang Shi, Zhongfu An
An AgCl/Ag3PO4 composite has been successfully fabricated by a simple desorption-precipitation method. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible spectroscopy (UV/Vis), and photoluminescence (PL) have been used to study the structural and physicochemical characteristics of the AgCl/Ag3PO4 composite. The photocatalytic activity of the AgCl/Ag3PO4 composite has been tested by the degradation of parabens under visible-light irradiation...
January 4, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29319206/butyl-paraben-promotes-apoptosis-in-human-trophoblast-cells-through-increased-oxidative-stress-induced-endoplasmic-reticulum-stress
#3
Changwon Yang, Whasun Lim, Fuller W Bazer, Gwonhwa Song
Butyl paraben (BP) has antimicrobial effects and is widely used as a preservative in cosmetics, foods, and pharmaceuticals. It is also absorbed into various tissues of the human body. It is known that BP is measurable in maternal and fetal tissues during pregnancy, but the effects of BP on placental development, essential for maintaining normal pregnancy, are unclear. Therefore, we investigated the effect of BP on the proliferation, apoptosis, and invasiveness of human trophoblast cells, using an HTR8/SVneo cell line...
January 10, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29317738/personal-care-product-use-as-a-predictor-of-urinary-concentrations-of-certain-phthalates-parabens-and-phenols-in-the-hermosa-study
#4
Kimberly P Berger, Katherine R Kogut, Asa Bradman, Jianwen She, Qi Gavin, Rana Zahedi, Kimberly L Parra, Kim G Harley
Use of personal care products, such as makeup, soaps, and sunscreen, may expose adolescent girls to potential endocrine disruptors, including phthalates, parabens, and other phenols. We evaluated the relationship between recent self-reported personal care product use and concentrations for urinary metabolites of phthalates, parabens, triclosan, and benzophenone-3 (BP-3) in 100 Latina adolescents. Girls who reported using makeup every day vs. rarely/never had higher urinary concentrations of monoethyl phthalate (MEP) (102...
January 9, 2018: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/29305513/production-of-4-hydroxybenzoic-acid-by-an-aerobic-growth-arrested-bioprocess-using-metabolically-engineered-corynebacterium-glutamicum
#5
Yukihiro Kitade, Ryoma Hashimoto, Masako Suda, Kazumi Hiraga, Masayuki Inui
Corynebacterium glutamicum was metabolically engineered to produce 4-hydroxybenzoic acid (4-HBA), a valuable aromatic compound used as a raw material for the production of liquid crystal polymers and paraben. C. glutamicum was found to have a higher tolerance to 4-HBA toxicity than previously reported hosts used for the production of genetically engineered 4-HBA. To obtain higher titers of 4-HBA, we employed a stepwise overexpression of all seven target genes in the shikimate pathway in C. glutamicum Specifically, multiple chromosomal integrations of a mutated aroG from Escherichia coli, encoding a DAHP synthase, and wild-type aroCKB from C...
January 5, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29291588/accurate-analysis-of-parabens-in-human-urine-using-isotope-dilution-ultrahigh-performance-liquid-chromatography-high-resolution-mass-spectrometry
#6
Hui-Ting Zhou, Hsin-Chang Chen, Wang-Hsien Ding
An analytical method that utilizes isotope-dilution ultrahigh-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS or called UHPLC-HRMS) was developed, and validated to be highly precise and accurate for the detection of nine parabens (methyl-, ethyl-, propyl-, isopropyl-, butyl-, isobutyl-, pentyl-, hexyl-, and benzyl-parabens) in human urine samples. After sample preparation by ultrasound-assisted emulsification microextraction (USAEME), the extract was directly injected into UHPLC-HRMS...
December 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29281926/investigation-of-genotoxic-effects-of-paraben-in-cultured-human-lymphocytes
#7
Devrim Güzel Bayülken, Berrin Ayaz Tüylü, Handan Sinan, Hülya Sivas
Paraben is a phenolic derivative of benzoic acid extensively used as preservatives in food, pharmaceutical, and cosmetic industries due to its antimicrobial characteristics. The objective of this study was to evaluate the in vitro genotoxic effects of paraben in human lymphocyte cultures. Cells were analyzed by cytokinesis-block micronucleus (CBMN), chromosome aberration (CA), sister chromatid exchange (SCE), and comet tests. For CBMN, CA, and SCE assays, the human lymphocytes were isolated from healthy donors and incubated with 500, 250, 100, and 50 µg/mL of paraben for 24 and 48 h, and for comet assay, cells were exposed to 1000, 750, 500, and 250 µg/mL of paraben for an hour...
December 27, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29275482/paraben-degradation-using-catalytic-ozonation-over-volcanic-rocks
#8
João F Gomes, Maria Emília Quinta-Ferreira, Raquel Costa, Rosa M Quinta-Ferreira, Rui C Martins
Parabens are widely used as antimicrobial and preservatives in pharmaceutical and personal care products and are continuously reaching the water streams. Conventional wastewater treatments are proven inefficient on the removal of this kind of contaminants from wastewater. Therefore, catalytic ozonation appears as a suitable option, due to the oxidant power of ozone and its high capacity of hydroxyl radical generation in the presence of a suitable catalyst. The main drawback of catalytic ozonation is related with the choice of stable and active catalysts at low cost...
December 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29248488/safety-assessment-of-propylparaben-in-juvenile-rats
#9
Lakshmi Sivaraman, Louise Pouliot, Bonnie Wang, Thomas Brodie, Michael Graziano, Mary Ellen McNerney
There are conflicting literature reports that parabens, useful antimicrobial additives in pharmaceuticals, may have estrogenic activity. We conducted a comprehensive study to determine whether propylparaben (PP) administration to juvenile rats is associated with adverse effects on reproductive development and function. PP was administered orally once daily to groups of Crl:CD(SD) rats at doses of 0 (vehicle), 10, 100, or 1000 mg/kg on Postnatal Days (PNDs) 4-90. In-life observations, clinical pathology, reproductive organ weights and histopathology, landmarks of sexual maturation, estrous cyclicity and functional reproductive competence were assessed...
December 14, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29229332/determination-of-household-and-industrial-chemicals-personal-care-products-and-hormones-in-leafy-and-root-vegetables-by-liquid-chromatography-tandem-mass-spectrometry
#10
Irene Aparicio, Julia Martín, Concepción Abril, Juan Luis Santos, Esteban Alonso
A multiresidue method has been developed for the determination of emerging pollutants in leafy and root vegetables. Selected compounds were 6 perfluoroalkyl compounds (5 perfluorocarboxylic acids and perfluorooctanesulfonic acid), 3 non-ionic surfactants (nonylphenol and nonylphenolethoxylates), 8 anionic surfactants (4 alkylsulfates and 4 linear alkylbenzene sulfonates), 4 preservatives (parabens), 2 biocides (triclosan and triclocarban), 2 plasticizers (bisphenol A and di-(2-ethylhexyl)phthalate), 6 UV-filters (benzophenones) and 4 hormones...
December 7, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29220766/a-global-framework-to-model-spatial-ecosystems-exposure-to-home-and-personal-care-chemicals-in-asia
#11
Cedric Wannaz, Antonio Franco, John Kilgallon, Juliet Hodges, Olivier Jolliet
This paper analyzes spatially ecosystem exposure to home and personal care (HPC) chemicals, accounting for market data and environmental processes in hydrological water networks, including multi-media fate and transport. We present a global modeling framework built on ScenAT (spatial scenarios of emission), SimpleTreat (sludge treatment plants), and Pangea (spatial multi-scale multimedia fate and transport of chemicals), that we apply across Asia to four chemicals selected to cover a variety of applications, volumes of production and emission, and physico-chemical and environmental fate properties: the anionic surfactant linear alkylbenzene sulphonate (LAS), the antimicrobial triclosan (TCS), the personal care preservative methyl paraben (MeP), and the emollient decamethylcyclopentasiloxane (D5)...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29216620/physicochemical-stability-of-an-oral-suspension-of-trimethoprim-20-mg-ml-in-combination-with-sulfadiazine-200-mg-ml-in-pcca-base-suspendit
#12
Richard A Graves, Kelly V Phan, Levon A Bostanian, Tarun K Mandal, Yashoda V Pramar
Trimethoprim is a diaminopyrimidine antibacterial agent that, like sulfonamides, inhibits bacterial folic acid synthesis, but at a different stage in the metabolic pathway. It has a similar spectrum of activity to the sulfonamides and is given by mouth or by injection, either alone or in conjunction with a sulfonamide, such as sulfadiazine. Sulfadiazine is a bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. The combination of the two drugs produces a synergistic effect against both Gram-positive and Gram-negative aerobic bacteria, by inhibiting enzymes in the folic acid pathways, which in turn inhibits bacterial thymidine synthesis...
September 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29188596/observed-differentials-in-the-levels-of-selected-environmental-contaminants-among-mexican-and-other-hispanic-american-children-adolescents-adults-and-senior-citizens
#13
Ram B Jain
Starting with the 2007-2008 cycle, the National Health and Nutrition Examination Survey (NHANES) also oversampled Hispanics other than Mexicans (OHISP) making it possible to treat OHISP as a separate demographic group along with Mexican Americans (MAs), non-Hispanic whites (NHWs), and non-Hispanic blacks (NHBs). Yet, more often than not, OHISP have been merged with MA to form an all-Hispanic demographic group (HISP) thus limiting comparisons between NHW, NHB, and HISP. Consequently, for the first time, this study was undertaken to evaluate differences in the observed levels of selected environmental contaminants between MA and OHISP from five groups of environmental contaminants, namely, polycyclic aromatic hydrocarbons (PAHs), iodine uptake inhibitors (IUIs), environmental phenols (EPHs), priority pesticides (PPs), and perfluoroalkyl acids (PFAAs)...
November 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29185724/bonding-of-butylparaben-bis-2-ethylhexyl-phthalate-and-perfluorooctanesulfonic-acid-to-dna-comparison-with-benzo-a-pyrene-shows-low-probability-for-strong-noncovalent-dna-intercalation
#14
Sergio Manzetti
Parabens, phthalates, and perfluorinated compounds are pollutant compounds used in cosmetics, plastics, and fire-fighting foams. All three compounds have been studied over several years for toxicity mechanism; however, a clear view of their ability to bind to DNA has not been supplied empirically. In this work, a simulation study is done to reveal the interaction of three of these pollutants, bis(2-ethylhexyl)-phthalate (DEHP), butylparaben (BPRB), and the protonated form of perfluorooctanesulfonic acid (PFOS(H)), with DNA...
November 29, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29179076/urinary-concentrations-of-parabens-and-reproductive-parameters-in-young-men
#15
Evdochia Adoamnei, Jaime Mendiola, Miriam Moñino-García, Fernando Vela-Soria, Luz M Iribarne-Durán, Mariana F Fernández, Nicolás Olea, Niels Jørgensen, Shanna H Swan, Alberto M Torres-Cantero
Parabens are a group of alkyl esters of p-hydroxybenzoic acid that are commonly added to personal care products, cosmetics, pharmaceuticals and beverage and food processing as antimicrobial preservatives. Parabens have been reported to show estrogenic effects and affect male reproduction function in animal models, but human epidemiologic studies are still scarce. The objective of this study was to examine associations between urinary concentrations of parabens and semen quality and reproductive hormone levels...
November 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29178629/analysis-of-emerging-organic-contaminants-in-poultry-manure-by-gc-ms-ms
#16
Ramón Aznar, Beatriz Albero, Rosa Ana Pérez, Consuelo Sánchez-Brunete, Esther Miguel, José L Tadeo
A multiresidue method was developed for the determination of 19 emerging organic contaminants (pharmaceutical drugs, personal care products and bisphenol A) in poultry manure. Lyophilized samples of manure were extracted by ultrasound-assisted matrix solid-phase dispersion and the extracts were analyzed by gas chromatography with tandem mass spectrometry after derivatization. Analysis of spiked poultry manure samples, at levels ranging from 25 to 150 ng g-1 , gave satisfactory recovery results for all the compounds, with values from 67 to 106 %...
November 27, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29165110/paraben-exposure-and-semen-quality-of-japanese-male-partners-of-subfertile-couples
#17
Yukiko Nishihama, Hiroki Toshima, Jun Yoshinaga, Yoshifumi Mizumoto, Miyuki Yoneyama, Daisuke Nakajima, Hiroaki Shiraishi, Susumu Tokuoka
OBJECTIVES: Possible relationship between semen quality (semen volume, sperm concentration and sperm motility) and parabens exposure was investigated in male partners of couples who visited a gynecology clinic in Tokyo for infertility consultation (n = 42, 36.8 ± 5.4 years). METHODS: Semen parameters were measured according to WHO guideline at the clinic, and urinary methyl- (MP), ethyl- (EP), propyl- (PP) and butyl (BP) paraben concentrations were measured with liquid chromatography-tandem mass spectrometry...
March 15, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29145094/a-mixture-of-five-endocrine-disrupting-chemicals-modulates-concentrations-of-bisphenol-a-and-estradiol-in-mice
#18
Tyler Pollock, Rachel E Weaver, Ramtin Ghasemi, Denys deCatanzaro
Most people in developed countries are exposed to multiple endocrine-disrupting synthetic chemicals. We previously showed that a single dose of triclosan, tetrabromobisphenol A (TBBPA), butyl paraben, propyl paraben, or di(2-ethylhexyl) phthalate elevated concentrations of bisphenol A (BPA) in mice. Here we investigated whether concurrent exposure to lower doses of these five chemicals could modulate concentrations of bisphenol A (BPA) or the natural estrogen, 17β-estradiol (E2). CF1 mice were injected subcutaneously with 0...
November 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29136910/low-cost-approach-to-increase-the-analysis-throughput-of-bar-adsorptive-microextraction-ba%C3%A2%C2%B5e-combined-with-environmentally-friendly-renewable-sorbent-phase-of-recycled-diatomaceous-earth
#19
Gabriela Mafra, Anderson Luiz Oenning, Adriana Neves Dias, Josias Merib, Dilma Budziak, Cristian Berto da Silveira, Eduardo Carasek
In this study, a novel apparatus for bar adsorptive microextraction (BAµE) using a voltage regulator was proposed as an alternative tool to improve the analysis throughput. In addition, recycled diatomaceous earth obtained as a brewery residue was employed as a biosorbent coating for the determination of methyl paraben, ethyl paraben, benzophenone and triclocarban in water samples by high-performance liquid chromatography-diode array detection (HPLC-DAD). The use of the extraction devices, comprised of floating adsorptive bars of 7...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136796/a-multi-purpose-tool-for-food-inspection-simultaneous-determination-of-various-classes-of-preservatives-and-biogenic-amines-in-meat-and-fish-products-by-lc-ms
#20
Luciano Molognoni, Heitor Daguer, Leandro Antunes de Sá Ploêncio, Juliano De Dea Lindner
This paper describes an innovative fast and multipurpose method for the chemical inspection of meat and fish products by liquid chromatography-tandem mass spectrometry. Solid-liquid extraction and low temperature partitioning were applied to 17 analytes, which included large bacteriocins (3.5kDa) and small molecules (organic acids, heterocyclic compounds, polyene macrolides, alkyl esters of the p-hydroxybenzoic acid, aromatic, and aliphatic biogenic amines and polyamines). Chromatographic separation was achieved in 10min, using stationary phase of di-isopropyl-3-aminopropyl silane bound to hydroxylated silica...
February 1, 2018: Talanta
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