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https://www.readbyqxmd.com/read/28609180/environmental-exposure-to-parabens-and-sperm-chromosome-disomy
#1
Joanna Jurewicz, Michał Radwan, Bartosz Wielgomas, Anna Klimowska, Paweł Kałużny, Paweł Radwan, Lucjusz Jakubowski, Wojciech Hanke
Parabens are widely used as antimicrobial preservatives in cosmetics, pharmaceuticals, food and beverage processing due to their board spectrum of activity, inertness, and low cost. The study population consisted of 156 men under 45 years of age who attended the infertility clinic for diagnostic purposes with normal semen concentration of 15-300 mln/ml. Participants were interviewed and provided a semen sample. The parabens concentrations: ethyl paraben (EP), butyl paraben (BP), methyl paraben (MP), and iso-butyl paraben (iBuP) were analyzed in the urine using a validated gas chromatography ion-tap mass spectrometry method...
June 13, 2017: International Journal of Environmental Health Research
https://www.readbyqxmd.com/read/28602299/fabrication-of-polymeric-ionic-liquid-modified-magnetic-adsorbent-for-extraction-of-apolar-and-polar-pollutants-in-complicated-samples
#2
Cheng Liu, Yingmin Liao, Xiaojia Huang
A new polymeric ionic liquid-modified magnetic adsorbent (PIL-MA) was successfully fabricated and used to extract apolar and polar pollutants with magnetic solid-phase extraction (MSPE). The PIL-MA was prepared by simple free radical copolymerization of 1-vinylbenzyl-3-methylimidazolium hexafluorophosphate, divinylbenzene and silica-coated magnetite. Several characterized techniques including infrared spectroscopy, elemental analysis, scanning electron microscopy, transmission electron microscopy and magnetic measurement were used to characterize the PIL-MA...
September 1, 2017: Talanta
https://www.readbyqxmd.com/read/28583316/formulation-development-and-evaluation-of-antimicrobial-polyherbal-gel
#3
S D Bhinge, M A Bhutkar, D S Randive, G H Wadkar, S S Todkar, P M Kakade, P M Kadam
OBJECTIVE: In the recent years, there has been a gradual revival of interest in the use of medicinal plants in developing countries because herbal medicines have been reported safe with minimal adverse side effect especially when compared with synthetic drugs. METHOD: In the present study we prepared gel formulations (formulations A and B) which comprised of ethanolic extract of Azadirachta indica, Curcuma longa, Allium sativum, Ocimum sactum, Cinnamomum zeylanicum nees and Tamarindus indica in a concentration of 0...
June 2, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/28575092/exploitation-of-trametes-versicolor-for-bioremediation-of-endocrine-disrupting-chemicals-in-bioreactors
#4
Cinzia Pezzella, Gemma Macellaro, Giovanni Sannia, Francesca Raganati, Giuseppe Olivieri, Antonio Marzocchella, Dietmar Schlosser, Alessandra Piscitelli
Endocrine disrupting chemicals (EDCs) are environmental contaminants causing increasing concerns due to their toxicity, persistence and ubiquity. In the present study, degradative capabilities of Trametes versicolor, Pleurotus ostreatus and Phanerochaete chrysosporium to act on five EDCs, which represent different classes of chemicals (phenols, parabens and phthalate) and were first applied as single compounds, were assessed. T. versicolor was selected due to its efficiency against target EDCs and its potentialities were exploited against a mixture of EDCs in a cost-effective bioremediation process...
2017: PloS One
https://www.readbyqxmd.com/read/28557831/female-exposure-to-endocrine-disrupting-chemicals-and-fecundity-a-review
#5
Lidia Mínguez-Alarcón, Audrey J Gaskins
PURPOSE OF REVIEW: Endocrine disrupting chemicals (EDCs) have been known for their ability to interfere with aspects of hormone action resulting in adverse health consequences among animals and humans; however, the effects of EDCs on human fecundity have shown inconsistent findings. This review summarizes the most recent epidemiologic literature from humans on the potential effects of female exposure to nonpersistent EDCs, specifically bisphenol A (BPA), phthalates, parabens, and triclosan, on fecundity, measured by markers of reproductive hormones, markers of ovulation or ovarian reserve, IVF outcomes, and time-to-pregnancy...
May 26, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28548971/allergic-contact-dermatitis-in-preservatives-current-standing-and-future-options
#6
Gustavo Deza, Ana M Giménez-Arnau
PURPOSE OF REVIEW: Preservatives are well known skin sensitizers and represent one of the main causes of contact allergy. The purpose of this article is to review the current state of contact sensitization induced by preservatives and point future alternatives for products' preservation. RECENT FINDINGS: Isothiazolinones currently are the most common preservatives responsible of contact allergy in Europe and in the United States, and although some regulatory interventions have been taken place, the current contact allergy outbreak is not yet under control...
May 25, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28535462/pharmaceutical-substances-in-ambient-particulates-a-preliminary-assessment
#7
Angelo Cecinato, Paola Romagnoli, Mattia Perilli, Catia Balducci
Till now, no attention has been paid to pharmaceuticals (PCs) in the air, though they are known to affect waters, soils, foods and biota. This paper describes the first attempt to characterize the PC occurrence in the air. Airborne particulates (PM10 or PM2.5 fractions, from Amsterdam, Netherland, Rome and Rende, Italy) were sampled on quartz fiber filter by means of pumping systems operating at medium-volume conditions (16 or 38.5 L min(-1)). The samples were solvent extracted through sonication with a dichloromethane:acetone:methanol mixture and reduced close to dryness; three fractions of the residue were separated through column chromatography; they comprised non polar, low polar and very polar organic compounds, respectively, and PCs were in the third one...
May 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28527915/methylparaben-and-butylparaben-alter-multipotent-mesenchymal-stem-cell-fates-towards-adipocyte-lineage
#8
Pan Hu, Haley Overby, Emily Heal, Shu Wang, Jiangang Chen, Chwan-Li Shen, Ling Zhao
Paraben esters and their salts are widely used as preservatives in cosmetics, personal care products, pharmaceuticals, and foods. We previously reported that parabens promoted adipocyte differentiation in vitro and increased adiposity but suppressed serum marker of bone formation in vivo. Here, we investigated the effects of parabens (methylparaben and butylparaben) on modulating cell fate of multipotent stem cell line C3H10T1/2. Both parabens modulated adipogenic, osteogenic, and chondrogenic differentiation of C3H10T1/2 cells in vitro...
May 17, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28527332/determination-of-parabens-in-human-urine-by-optimal-ultrasound-assisted-emulsification-microextraction-and-on-line-acetylation-gas-chromatography-mass-spectrometry
#9
Zhou Hui-Ting, Erica M C Ding, Wang-Hsien Ding
An effective and solvent-less method for the rapid determination of four commonly detected parabens (methyl-, ethyl-, propyl- and butyl-) in human urine samples is described. This method employed ultrasound-assisted emulsification microextraction (USAEME) before identification and quantitation of the parabens via on-line acetylation gas chromatography-mass spectrometry (GC-MS). Urine samples were enzymatically de-conjugated with β-glucuronidase and then extracted by an optimal USAEME procedure for the measurement of total concentrations of target analytes...
May 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28526231/exposures-to-endocrine-disrupting-chemicals-in-consumer-products-a-guide-for-pediatricians
#10
Katelyn H Wong, Timur S Durrani
Endocrine disrupting chemicals, a group of exogenous chemicals that can interfere with hormone action in the body, have been implicated in disrupting endocrine function, which negatively affects human health and development. Endocrine disrupting chemicals are ubiquitously detected in consumer products, foods, beverages, personal care products, and household cleaning products. Due to concerns about their negative effects on human health, several professional health provider societies have recommended the reduction of common endocrine disrupting chemical exposures...
May 16, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28525834/exposure-to-phenols-parabens-and-uv-filters-associations-with-loss-of-function-mutations-in-the-filaggrin-gene-in-men-from-the-general-population
#11
Ulla N Joensen, Niels Jørgensen, Jacob P Thyssen, Jørgen Holm Petersen, Pal B Szecsi, Steen Stender, Anne-Maria Andersson, Niels E Skakkebæk, Hanne Frederiksen
BACKGROUND: Filaggrin is an epidermal protein that is important for normal skin barrier functions. Up to 10% of Europeans and Asians carry filaggrin gene (FLG) loss-of function mutations that appear to facilitate trans-epidermal penetration of certain chemicals. We previously showed that mutation carriers have higher internal exposure to certain phthalates, compared to controls, and hypothesized that they could have increased trans-epidermal penetration of other chemicals. OBJECTIVES: We investigated exposure to non-persistent chemicals in young Danish men with and without FLG mutations...
May 16, 2017: Environment International
https://www.readbyqxmd.com/read/28525533/phenol-concentrations-during-childhood-and-subsequent-measures-of-adiposity-among-young-girls
#12
Andrea L Deierlein, Mary S Wolff, Ashley Pajak, Susan M Pinney, Gayle C Windham, Maida P Galvez, Michael Rybak, Antonia M Calafat, Lawrence H Kushi, Frank M Biro, Susan L Teitelbaum
Phenolic compounds represent a class of environmental chemicals with potential endocrine disrupting capabilities. We investigated longitudinal associations of childhood exposures to phenols, from both man-made and natural sources, and subsequent measures of adiposity among girls enrolled in The Breast Cancer and Environment Research Program, 2004-2007. Baseline (ages 6-8 years) urinary concentrations were obtained for creatinine and phenol metabolites: enterolactone, genistein, daidzein, benzophenone-3, bisphenol A, sum of parabens (methyl, ethyl, and propyl parabens), 2,5-dichlorophenol, and triclosan...
May 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28502468/magnetically-assisted-matrix-solid-phase-dispersion-for-extraction-of-parabens-from-breast-milks
#13
Mina Fotouhi, Shahram Seidi, Maryam Shanehsaz, Mohammad Taghi Naseri
In the present work, magnetically assisted matrix solid phase dispersion (MA-MSPD) was used as an efficient solid phase extraction method. MA-MSPD followed by a dispersive liquid-liquid microextraction (DLLME) was applied for determination of parabens in breast milks. The analysis were performed using LC-UV and LC-MS/MS. Poly(indole-thiophene) coated magnetic graphene oxide (MGO@PIT) was synthesized, characterized and used as the sorbent. Na2SO4 was used as the drying salt as well as matrix dispersing agent...
May 5, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28501195/recycling-polymer-residues-to-synthesize-magnetic-nanocomposites-for-dispersive-micro-solid-phase-extraction
#14
Hoda Ghambari, Emilia M Reyes-Gallardo, Rafael Lucena, Mohammad Saraji, Soledad Cárdenas
The ubiquitous presence of plastics, an obvious consequence of their usefulness and low price, has turned them into a problem of environmental and safety concern. The new plastic economy, an initiative recently launched by the World Economic Forum and Ellen MacArthur Foundation, with analytical support from McKinsey & Company, promotes a change in the use of plastic worldwide around three main pillars: redesign, reusing and recycling. Recycled plastics, with the aim of extending their life spam, can be used to synthesize materials for analytical purposes...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28497013/racial-ethnic-disparities-in-environmental-endocrine-disrupting-chemicals-and-women-s-reproductive-health-outcomes-epidemiological-examples-across-the-life-course
#15
Tamarra M James-Todd, Yu-Han Chiu, Ami R Zota
Disparities in women's reproductive health outcomes across the life course have been well-documented. Endocrine disrupting chemicals may be one factor driving disparities, as studies suggest exposure to certain environmental endocrine disrupting chemicals, such as certain phthalates, bisphenol A, parabens and polybrominated diphenyl ethers are higher in non-whites. Yet, a limited amount of research has focused on these chemical exposures as a potential mediator of racial/ethnic differences in women's reproductive health outcomes, such as pubertal development, fibroids, infertility, and pregnancy complications...
June 2016: Current Epidemiology Reports
https://www.readbyqxmd.com/read/28478814/fragrance-compounds-the-wolves-in-sheep-s-clothings
#16
Seema Patel
In the past few decades, synthetic fragrance compounds have become ubiquitous components of personal care and household cleaning products. Overwhelming consumerism trends have led to the excess usage of these chemicals. It has been observed that this fragrance-laden unhealthy lifestyle runs parallel with the unprecedented rates of diabetes, cancer, neural ailments, teratogenicity, and transgender instances. The link between fragrances as and the multiplicity of pathogens remained latent for decades. However, now this health hazard and its role in homeostasis breakdown is getting attention...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28468729/trapping-multiple-dual-mode-centrifugal-partition-chromatography-for-the-separation-of-intermediately-eluting-components-throughput-maximization-strategy
#17
Raena Morley, Mirjana Minceva
Trapping multiple dual mode centrifugal partition chromatography (trapping MDM CPC) is an alternative to isocratic pulse injections for the separation of intermediately-eluting components from complex mixtures using liquid-liquid chromatography. In this work, a throughput maximization strategy is developed and validated to investigate the full potential of trapping MDM CPC as a preparative technique. In the proposed approach, shake flask and stationary phase retention experiments are used to determine the maximum feed concentration and flow rate, respectively...
April 20, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28466639/side-chains-of-parabens-modulate-antiandrogenic-activity-in-vitro-and-molecular-docking-studies
#18
Keke Ding, Xiaotian Kong, Jingpeng Wang, Liping Lu, Wenfang Zhou, Tingjie Zhan, Chunlong Zhang, Shulin Zhuang
Parabens have been widely used in packaged foods, pharmaceuticals, and personal-care products. Considering their potential hydrolysis, we herein investigated structural features leading to the disruption of human androgen receptor (AR) and whether hydrolysis could alleviate such effects using the recombinant yeast two-hybrid assay. Parabens with an aryloxy side chain such as benzyl paraben and phenyl paraben have the strongest antiandrogenic activity. The antiandrogenic activity of parabens with alkyloxyl side chains decreases as the side chain length increases from 1 to 4, and no antiandrogenic effect occurred for heptyl, octyl, and dodecyl parabens with the number of alkoxyl carbon atoms longer than 7...
June 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28421984/stability-indicating-uplc-method-for-the-estimation-of-nadifloxacin-terbinafine-hydrochloride-mometasone-furoate-methyl-paraben-and-propyl-paraben-in-topical-pharmaceutical-dosage-form
#19
Dileep M Bhosale, Anna Pratima G Nikalje
A novel and simple ultra-performance LC method was developed for the estimation of nadifloxacin (NAD), terbinafine hydrochloride (TBH), mometasone furoate (MMF), methyl paraben (MP), and propyl paraben (PP) in a topical pharmaceutical dosage formulation. The analysis was carried out on a Waters Acquity UPLC ethylene bridged hybrid C18 column (50 × 2.1 mm, 1.7 μm) with a flow rate of 0.4 mL/min in gradient mode at a wavelength of 255 nm. Elution of all components was achieved within 9 min. The retention times of MP, NAD, PP, TBH, and MMF were observed at 1...
April 18, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28416215/stir-bar-sorptive-extraction-and-liquid-chromatography-tandem-mass-spectrometry-determination-of-polar-and-non-polar-emerging-and-priority-pollutants-in-environmental-waters
#20
Irene Aparicio, Julia Martín, Juan Luis Santos, José Luis Malvar, Esteban Alonso
An analytical method based on stir bar sorptive extraction (SBSE) was developed and validated for the determination of environmental concern pollutants in environmental waters by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Target compounds include six water and oil repellents (perfluorinated compounds), four preservatives (butylated hydroxytoluene and three parabens), two plasticizers (bisphenol A and di(2-ethylhexyl)phthalate), seven surfactants (four linear alkylbenzene sulfonates, nonylphenol and two nonylphenol ethoxylates), a flame retardant (hexabromocyclododecane), four hormones, fourteen pharmaceutical compounds, an UV-filter (2-ethylhexyl 4-methoxycinnamate) and nine pesticides...
April 7, 2017: Journal of Chromatography. A
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