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Paraben

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https://www.readbyqxmd.com/read/28421984/stability-indicating-uplc-method-for-the-estimation-of-nadifloxacin-terbinafine-hydrochloride-mometasone-furoate-methyl-paraben-and-propyl-paraben-in-topical-pharmaceutical-dosage-form
#1
Dileep M Bhosale, Anna Pratima G Nikalje
A novel and simple ultra-performance LC method was developed for the estimation of nadifloxacin (NAD), terbinafine hydrochloride (TBH), mometasone furoate (MMF), methyl paraben (MP), and propyl paraben (PP) in a topical pharmaceutical dosage formulation. The analysis was carried out on a Waters Acquity UPLC ethylene bridged hybrid C18 column (50 × 2.1 mm, 1.7 μm) with a flow rate of 0.4 mL/min in gradient mode at a wavelength of 255 nm. Elution of all components was achieved within 9 min. The retention times of MP, NAD, PP, TBH, and MMF were observed at 1...
April 18, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28416215/stir-bar-sorptive-extraction-and-liquid-chromatography-tandem-mass-spectrometry-determination-of-polar-and-non-polar-emerging-and-priority-pollutants-in-environmental-waters
#2
Irene Aparicio, Julia Martín, Juan Luis Santos, José Luis Malvar, Esteban Alonso
An analytical method based on stir bar sorptive extraction (SBSE) was developed and validated for the determination of environmental concern pollutants in environmental waters by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Target compounds include six water and oil repellents (perfluorinated compounds), four preservatives (butylated hydroxytoluene and three parabens), two plasticizers (bisphenol A and di(2-ethylhexyl)phthalate), seven surfactants (four linear alkylbenzene sulfonates, nonylphenol and two nonylphenol ethoxylates), a flame retardant (hexabromocyclododecane), four hormones, fourteen pharmaceutical compounds, an UV-filter (2-ethylhexyl 4-methoxycinnamate) and nine pesticides...
April 7, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28408822/negatively-charged-silver-nanoparticles-with-potent-antibacterial-activity-and-reduced-toxicity-for-pharmaceutical-preparations
#3
Lucia Salvioni, Elisabetta Galbiati, Veronica Collico, Giulia Alessio, Svetlana Avvakumova, Fabio Corsi, Paolo Tortora, Davide Prosperi, Miriam Colombo
BACKGROUND: The discovery of new solutions with antibacterial activity as efficient and safe alternatives to common preservatives (such as parabens) and to combat emerging infections and drug-resistant bacterial pathogens is highly expected in cosmetics and pharmaceutics. Colloidal silver nanoparticles (NPs) are attracting interest as novel effective antimicrobial agents for the prevention of several infectious diseases. METHODS: Water-soluble, negatively charged silver nanoparticles (AgNPs) were synthesized by reduction with citric and tannic acid and characterized by transmission electron microscopy, dynamic light scattering, zeta potential, differential centrifuge sedimentation, and ultraviolet-visible spectroscopy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28390971/butyl-paraben-and-propyl-paraben-modulate-bisphenol-a-and-estradiol-concentrations-in-female-and-male-mice
#4
Tyler Pollock, Rachel E Weaver, Ramtin Ghasemi, Denys deCatanzaro
People are routinely exposed to the antimicrobial preservatives butyl paraben (BP) and propyl paraben (PP), as well as the monomer of polycarbonate plastics, bisphenol A (BPA). These chemicals are reliably detected in human urine and potentially interact. We investigated whether BP or PP exposure can modulate the concentrations of (14)C-BPA and 17β-estradiol (E2). Female and male CF1 mice were each given a subcutaneous injection of oil containing 0 (vehicle), 1, 3, or 9mg BP or PP, then given a dietary supplement containing 50μg/kg (14)C-BPA...
April 5, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28382686/methylparaben-induced-decrease-in-collagen-production-and-viability-of-cultured-human-dermal-fibroblasts
#5
Natalia Majewska, Ilona Zaręba, Arkadiusz Surażyński, Anna Galicka
Parabens owing to their many advantageous properties are widely applied in cosmetics, food products and pharmaceuticals. However, recent research results have shown that they possess the ability to accumulate in the human body and exert many adverse effects. In this study, the impact of methylparaben (MP) as the most frequently used preservative in cosmetics, on human dermal fibroblasts and collagen production was evaluated. In cells treated with 0.01, 0.03 and 0.05% MP a dose-dependent decrease in collagen biosynthesis was revealed, which was positively correlated with the activity of prolidase responsible for the recovery of proline...
April 6, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28379057/metoclopramide-nasal-spray-in-vitro-evaluation-and-in-vivo-pharmacokinetic-studies-in-dogs
#6
Ying Li, Xianpeng Fan, Wanqing Li, Peng Yang, Hui Zhang, Daoquan Tang, Xiaoxin Yin, Jianxu Sun, Aiping Zheng
Metoclopramide (MCP) can effectively alleviate motion sickness-caused nausea and vomiting. Nasal administration offers the greatest patient compliance. It is suitable for self-administration and offers rapid and complete absorption, no first-pass effects, and high bioavailability. In present study, a MCP nasal spray was prepared and evaluated in vitro and in vivo. Nasal cilia toxicity of Bufo toads was used to screen the preservative types and concentrations. Rabbit nasal mucosa was used to evaluate the mucosa permeability of different MCP nasal sprays with different penetration enhancers and preservative...
April 5, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28376394/co-metabolic-enhancement-of-organic-removal-from-waste-water-in-the-presence-of-high-levels-of-alkyl-paraben-constituents-of-cosmetic-and-personal-care-products
#7
Chihhao Fan, Shin-Chih Wang
The enhanced removal of organic material from municipal waste water containing 50 mg/L of chemical oxygen demand and a given amount of alkyl paraben using a biofilm system was investigated. The parabens used were methyl, ethyl, and propyl paraben. The experiments were conducted at influent paraben concentrations of 10 and 50 mg/L. The influent pH was measured around 4.6 because of paraben hydrolysis. The effluent pH increased due to hydrogen consumption and small molecular acid generation. The higher removal rates were observed for the paraben with longer alkyl chains, which were more hydrophobic and capable of penetrating into microbial cells...
July 2017: Chemosphere
https://www.readbyqxmd.com/read/28370680/rapid-and-sensitive-determination-of-multiple-endocrine-disrupting-chemicals-by-ultrasound-assisted-in-situ-derivatization-dispersive-liquid-liquid-microextraction-coupled-with-uhplc-ms-ms
#8
Na Wei, Zhenjia Zheng, Yuhua Wang, Yanduo Tao, Yun Shao, Shuyun Zhu, Jinmao You, Xian-En Zhao
RATIONALE: Endocrine disrupting chemicals (EDCs) in environment samples and food stuffs are an increasing serious public health issue due to their potency to interfere and deregulate several aspects of the endocrine system. Because of their extremely low abundance, it remains a challenging task to develop a sensitive detection method. METHODS: 4'-Carbonyl chloride rosamine (CCR) was used as a derivatization reagent for EDCs for the first time. A new ultrasound-assisted in situ derivatization-dispersive liquid-liquid microextraction (UA-DLLME with in situ derivatization) method for multiple EDCs including five estrogens, two alkylphenols, eight bisphenols, seven parabens and triclosan coupled with ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) has been developed and validated...
March 31, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28363416/trapping-multiple-dual-mode-centrifugal-partition-chromatography-for-the-separation-of-intermediately-eluting-components-operating-parameter-selection
#9
Johannes Goll, Raena Morley, Mirjana Minceva
The preparative separation of intermediately-eluting components in liquid-liquid chromatography is commonly performed with isocratic batch injections, a technique which often leads to low yield and/or purity as a result of peak overlap. Two-column trapping multiple dual mode centrifugal partition chromatography, an alternative discontinuous method for the separation of a mixture into three product fractions (early-, intermediately-, and late-eluting components) at full recovery, is presented in this work. A mathematical shortcut method based on equilibrium theory assumptions is derived for the determination of the key operating parameters (i...
March 20, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28360009/occurrence-and-fate-of-parabens-and-their-metabolites-in-five-sewage-treatment-plants-in-india
#10
Rajendiran Karthikraj, Anuji K Vasu, Keshava Balakrishna, Ravindra K Sinha, Kurunthachalam Kannan
Parabens (p-hydroxy benzoic acid esters) are antimicrobial agents, used widely as preservatives in personal care products (PCPs), pharmaceuticals, foods, and beverages. PCPs that contain parabens are a major source of these chemicals in sewage treatment plants (STPs). Very few studies have demonstrated the occurrence of parabens in wastewater. In this study, the occurrence and fate of six parabens, methyl-(MeP), ethyl-(EtP), propyl-(PrP), butyl-(BuP), hepty-(HpP) and benzyl-(BzP) parabens, and five of their metabolites (4-HB, 3,4-DHB, OH-MeP, OH-EtP and BA) were studied in five STPs in India...
March 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28356401/exposure-to-endocrine-disruptors-during-adulthood-consequences-for-female-fertility
#11
Saniya Rattan, Changqing Zhou, Catheryne Chiang, Sharada Mahalingam, Emily Brehm, Jodie Flaws
Endocrine disrupting chemicals are ubiquitous chemicals that exhibit endocrine disrupting properties in both humans and animals. Female reproduction is an important process, which is regulated by hormones and is susceptible to the effects of exposure to endocrine disrupting chemicals. Disruptions in female reproductive functions by endocrine disrupting chemicals may result in subfertility, infertility, improper hormone production, estrous and menstrual cycle abnormalities, anovulation, and early reproductive senescence...
March 29, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28346910/occurrence-temporal-variation-and-estrogenic-burden-of-five-parabens-in-sewage-sludge-collected-across-the-united-states
#12
Jing Chen, Benny F G Pycke, Bruce J Brownawell, Chad A Kinney, Edward T Furlong, Dana W Kolpin, Rolf U Halden
Five parabens used as preservatives in pharmaceuticals and personal care products (PPCPs) were measured in sewage sludges collected at 14 U.S. wastewater treatment plants (WWTPs) located in nine states. Detected concentration ranges (ng/g, dry weight) and frequencies were as follows: methyl paraben (15.9 to 203.0; 100%), propyl paraben (0.5 to 7.7; 100%), ethyl paraben (<0.6 to 2.6; 63%), butyl paraben (<0.4 to 4.3; 42%) and benzyl paraben (<0.4 to 3.3; 26%). The estrogenicity inherent to the sum of parabens detected in sewage sludge (ranging from 10...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28342347/assumed-non-persistent-environmental-chemicals-in-human-adipose-tissue-matrix-stability-and-correlation-with-levels-measured-in-urine-and-serum
#13
F Artacho-Cordón, J P Arrebola, O Nielsen, P Hernández, N E Skakkebaek, M F Fernández, A M Andersson, N Olea, H Frederiksen
The aim of this study was to (1) optimize a method for the measurement of parabens and phenols in adipose tissue, (2) evaluate the stability of chemical residues in adipose tissue samples, and (3) study correlations of these compounds in urine, serum, and adipose tissue. Samples were obtained from adults undergoing trauma surgery. Nine phenols and seven parabens were determined by isotope diluted TurboFlow-LC-MS/MS. The analytical method showed good accuracy and precision. Limits of detection (LOD) for parabens and phenols ranged from 0...
March 22, 2017: Environmental Research
https://www.readbyqxmd.com/read/28339377/stability-of-clindamycin-hydrochloride-in-pcca-base-suspendit
#14
Yashoda V Pramar, Richard A Graves, Grace A Ledet, Kelly V Phan, Levon A Bostanian, Tarun K Mandal
Clindamycin is an effective antibiotic in the treatment of infections caused by certain gram-positive and gram-negative anaerobic microorganisms. While manufactured forms of the drug for pediatric use are available, there are instances when a compounded liquid dosage form is essential to meet unique patient needs. The purpose of this study was to determine the chemical stability of clindamycin hydrochloride in the PCCA base SuspendIt, a sugar-free, paraben- free, dye-free, and gluten-free thixotropic vehicle containing a natural sweetener obtained from the monk fruit...
September 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28338538/allergenic-ingredients-in-facial-wet-wipes
#15
Kelly A Aschenbeck, Erin M Warshaw
BACKGROUND: Allergic contact dermatitis commonly occurs on the face. Facial cleansing wipes may be an underrecognized source of allergens. OBJECTIVE: The aim of this study was to determine the frequency of potentially allergenic ingredients in facial wet wipes. METHODS: Ingredient lists from name brand and generic facial wipes from 4 large retailers were analyzed. RESULTS: In the 178 facial wipes examined, a total of 485 ingredients were identified (average, 16...
March 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/28338537/allergenic-ingredients-in-personal-hygiene-wet-wipes
#16
Kelly A Aschenbeck, Erin M Warshaw
BACKGROUND: Wet wipes are a significant allergen source for anogenital allergic contact dermatitis. OBJECTIVE: The aim of the study was to calculate the frequency of potentially allergenic ingredients in personal hygiene wet wipes. METHODS: Ingredient lists from brand name and generic personal hygiene wet wipes from 4 large retailers were compiled. RESULTS: In the 54 personal hygiene wet wipes evaluated, a total of 132 ingredients were identified (average of 11...
March 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/28324817/developmental-toxicity-and-induction-of-vitellogenin-in-embryo-larval-stages-of-zebrafish-danio-rerio-exposed-to-methyl-paraben
#17
Vrinda Yatin Dambal, Karthikeyan Ponnien Selvan, Christy Lite, S Barathi, Winkins Santosh
MethylParaben (MP), a methyl ester of p-hydroxybenzoic acid, is used as an anti-microbial preservative in foods, drugs and cosmetics for decades. It enters the aquatic environment, and can have toxic effects on aquatic organisms. Little is known on the developmental toxicity of MP exposure to zebrafish during early life stages. In this study, the developmental effects of MP were evaluated in embryo-larval zebrafish (at concentrations ranging from 100μM, 200μM, 400µM, 800μM and 1000μM for 96h post fertilization (hpf)...
March 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28318231/paraben-concentrations-in-maternal-urine-and-breast-milk-and-its-association-with-personal-care-product-use
#18
Mandy Fisher, Susan MacPherson, Joseph M Braun, Russ Hauser, Mark Walker, Mark Feeley, Ranjeeta Mallick, René Bérubé, Tye E Arbuckle
Parabens are broad-spectrum antimicrobial preservatives and fragrances used in a wide range of personal care products, pharmaceuticals, and food providing the opportunity for people to be exposed on a daily basis. In 2009-2010, 80 pregnant women from Ottawa Canada participated in the Plastics and Personal-Care Product Use in Pregnancy (P4) Study. A subset of women (n = 31) who provided multiple spot urine samples (n = 542) collected over two 24-h periods had their samples analyzed for methylparaben (MP), n-propylparaben (PP), ethylparaben (EP), butylparaben (BP), isobutylparaben (IBP), and benzylparaben (BzP)...
March 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28315385/a-study-on-the-in-vitro-percutaneous-absorption-of-silver-nanoparticles-in-combination-with-aluminum-chloride-methyl-paraben-or-di-n-butyl-phthalate
#19
Katarzyna Domeradzka-Gajda, Marek Nocuń, Joanna Roszak, Beata Janasik, C Derrick Quarles, Wojciech Wąsowicz, Jarosław Grobelny, Emilia Tomaszewska, Grzegorz Celichowski, Katarzyna Ranoszek-Soliwoda, Małgorzata Cieślak, Dorota Puchowicz, Jhanis J Gonzalez, Richard E Russo, Maciej Stępnik
Some reports indicate that the silver released from dermally applied products containing silver nanoparticles (AgNP) (e.g. wound dressings or cosmetics) can penetrate the skin, particularly if damaged. AgNP were also shown to have cytotoxic and genotoxic activity. In the present study percutaneous absorption of AgNP of two different nominal sizes (Ag15nm or Ag45nm by STEM) and surface modification, i.e. citrate or PEG stabilized nanoparticles, in combination with cosmetic ingredients, i.e. aluminum chloride (AlCl3), methyl paraben (MPB), or di-n-butyl phthalate (DBPH) was assessed using in vitro model based on dermatomed pig skin...
March 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28306542/biomonitoring-of-danish-school-children-and-mothers-including-biomarkers-of-pbde-and-glyphosate
#20
Lisbeth E Knudsen, Pernille Winton Hansen, Seher Mizrak, Heidi K Hansen, Thit A Mørck, Flemming Nielsen, Volkert Siersma, Line Mathiesen
BACKGROUND: The Danish part of the large European Human biomonitoring pilot project Demonstration of a study to Coordinate and Perform Human biomonitoring on a European Scale (DEMOCOPHES) investigated the urine, hair and blood concentrations of 66 different environmental chemicals in a group of 145 Danish school children aged 6-11 years and their mothers from rural and urban areas in autumn 2011. Some - but not all - results were published; however, the concurrence of the chemicals has not been assessed...
March 17, 2017: Reviews on Environmental Health
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