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Paraben

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https://www.readbyqxmd.com/read/28213243/multi-residue-analysis-of-36-priority-and-emerging-pollutants-in-marine-echinoderms-holothuria-tubulosa-and-marine-sediments-by-solid-liquid-extraction-followed-by-dispersive-solid-phase-extraction-and-liquid-chromatography-tandem-mass-spectrometry-analysis
#1
J Martín, A Zafra-Gómez, F Hidalgo, A J Ibáñez-Yuste, E Alonso, J L Vilchez
Marine echinoderms are filter-feeding invertebrates widely distributed along the coasts, and which are therefore extensively exposed to anthropogenic xenobiotics. They can serve as good sentinels for monitoring a large variety of contaminants in marine ecosystems. In this context, a multi-residue analytical method has been validated and applied to Holothuria tubulosa specimens and marine sediments for the determination of 36 organic compounds, which belong to some of the most problematic groups of emerging and priority pollutants (perfluoroalkyl compounds, estrogens, parabens, benzophenones, plasticizers, surfactants, brominated flame retardants and alkylphenols)...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28208728/parabens-accelerate-ovarian-dysfunction-in-a-4-vinylcyclohexene-diepoxide-induced-ovarian-failure-model
#2
Jae-Hwan Lee, Myeongho Lee, Changhwan Ahn, Hee Young Kang, Dinh Nam Tran, Eui-Bae Jeung
Parabens are widely used preservatives in basic necessities such as cosmetic and pharmaceutical products. In previous studies, xenoestrogenic actions of parabens were reported in an immature rat model and a rat pituitary cell line (GH3 cells). The relationship between parabens and ovarian failure has not been described. In the present study, the influence of parabens on ovarian folliculogenesis and steroidogenesis was investigated. A disruptor of ovarian small pre-antral follicles, 4-vinylcyclohexene diepoxide (VCD, 40 mg/kg), was used to induce premature ovarian failure (POF)...
February 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28194803/the-current-spectrum-of-contact-sensitization-in-patients-with-chronic-leg-ulcers-or-stasis-dermatitis%C3%A2-%C3%A2-new-data-from-the-information-network-of-departments-of-dermatology-ivdk
#3
Cornelia Erfurt-Berge, Johannes Geier, Vera Mahler
BACKGROUND: Patients with lower leg dermatitis, chronic venous insufficiency or chronic leg ulcers have a high prevalence of contact sensitization. OBJECTIVES: To identify the current spectrum of contact allergens in these patients. PATIENTS AND METHODS: Data of the Information Network of Departments of Dermatology on 5264 patients with the above diagnoses from the years 2003 to 2014 (study group) were compared with data on 4881 corresponding patients from 1994 to 2003 (historical control group) and with a current control group without these diagnoses (n = 55 510)...
February 14, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28181406/endocrine-disrupting-effects-of-methylparaben-on-the-adult-gerbil-prostate
#4
Janaína R Costa, Mônica S Campos, Rodrigo F Lima, Liana S Gomes, Mara R Marques, Sebastião R Taboga, Manoel F Biancardi, Pedro V A Brito, Fernanda C A Santos
Parabens are xenoestrogens widely employed in cosmetics, foodstuffs, and pharmaceutical products. These chemicals are known to disrupt hormone-dependent organs, due to their binding affinity for hormonal receptors. Although recent studies have evaluated the endocrine-disrupting potential of parabens in several reproductive organs, few have investigated the effects of these chemicals in the prostate. The aim of this work was to evaluate the effects of oral exposure to methylparaben (500 mg/kg/day) for 3, 7, and 21 days on male and female adult gerbil prostate...
February 9, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28159478/identification-of-exposure-to-environmental-chemicals-in-children-and-older-adults-using-human-biomonitoring-data-sorted-by-age-results-from-a-literature-review
#5
Judy Choi, Lisbeth E Knudsen, Seher Mizrak, Anke Joas
Human biomonitoring (HBM) provides the tools for exposure assessment by direct measurements of biological specimens such as blood and urine. HBM can identify new chemical exposures, trends and changes in exposure, establish distribution of exposure among the general population, and identify vulnerable groups and populations with distinct exposures such as children and older adults. The objective of this review is to demonstrate the use of HBM to identify environmental chemicals that might be of concern for children or older adults due to higher body burden...
December 21, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28157063/safe-excipient-exposure-in-neonates-and-small-children-protocol-for-the-seen-project
#6
Kristine Svinning Valeur, Steen Axel Hertel, Kaare Engell Lundstrøm, Helle Holst
INTRODUCTION: The pharmacokinetics of excipients in neonates differs from that of older children. In a recent pan--European survey, two thirds of neonates received at least one potentially harmful excipient, such as ethanol and benzoates. The content of sweeteners varied by route of administration (more common by enteral than parenteral route), and regional differences were revealed. The survey did not identify if the content of excipients was more pronounced in medications prescribed for specific medical diseases, e...
February 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28153288/a-simple-and-fast-double-flow-microfluidic-device-based-liquid-phase-microextraction-df-%C3%A2%C2%B5lpme-for-the-determination-of-parabens-in-water-samples
#7
María Ramos-Payan, Santiago Maspoch, Andreu Llobera
A fast double-flow microfluidic based liquid phase microextraction (DF-µLPME) combined with a HPLC-UV procedure using diode array detection has been developed for the determination of the four most widely used parabens: Ethyl 4-hydroxybenzoate (EtP), Propyl 4-hydroxybenzoate (PrP), Butyl 4-hydroxybenzoate (BuP) and IsoButyl 4-hydroxybenzoate (iBuP) in water samples. Parabens have successfully been determined in environmental (lake and river water) samples with excellent clean up, high extraction efficiency and good enrichment factor using double-flow conditions...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28143664/use-of-graphene-supported-on-aminopropyl-silica-for-microextraction-of-parabens-from-water-samples
#8
Bruno Henrique Fumes, Fernando Mauro Lanças
This paper describes the synthesis, characterization and use of graphene supported on aminopropyl silica through covalent bonds (Si-G) as a sorbent for microextraction by packed sorbent (MEPS). Five parabens (methyl, ethyl, propyl, butyl and benzyl) present in water matrices were used as model compounds for this evaluation. The Si-G phase was compared to other sorbents used in MEPS (C18 and Strata™-X) and also with graphene supported on primary-secondary amine (PSA) silica, where Si-G showed better results...
March 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28129936/assessment-of-parabens-and-ultraviolet-filters-in-human-placenta-tissue-by-ultrasound-assisted-extraction-and-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#9
F Vela-Soria, M E Gallardo-Torres, O Ballesteros, C Díaz, J Pérez, A Navalón, M F Fernández, N Olea
Increasing concerns have been raised over recent decades about human exposure to Endocrine Disrupting Chemicals (EDCs), especially about their possible effects on embryo, foetus, newborn, and child. Parabens (PBs) and ultraviolet filters (UV-filters) are prevalent EDCs widely used as additives in cosmetics and personal care products (PCPs). The objective of this study was to determine the presence of four PBs and ten UV-filters in placental tissue samples using a novel analytical method based on ultrasound-assisted extraction (UAE) and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)...
March 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28118580/chemometrics-assisted-fast-elution-hplc-dad-for-the-quantification-of-selected-uv-filters-and-parabens-in-suncare-formulations
#10
Maryam Vosough, Nafiseh Shekari, Amir Salemi, Koorosh Tabar Heidar
In the present study, a fast LC method coupled with multivariate curve resolution (MCR) alternating least-squares (ALS)and alternating trilinear decomposition (ATLD) was developed for the determination of the resolution of and quantitation of benzophenone-3, 4-methylbenzylidene camphor, octocrylene, ethylhexyl dimethyl para-aminobenzoic acid, butyl methoxydibenzoilmethane, and methyl and propyl parabens in suncare products. Chromatographic separation was optimized using full factorial and Box-Behnken designs...
November 30, 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/28105593/monitoring-pharmaceuticals-and-personal-care-products-in-reservoir-water-used-for-drinking-water-supply
#11
Carolina Aristizabal-Ciro, Ana María Botero-Coy, Francisco J López, Gustavo A Peñuela
In this work, the presence of selected emerging contaminants has been investigated in two reservoirs, La Fe (LF) and Rio Grande (RG), which supply water to two drinking water treatment plants (DWTPs) of Medellin, one of the most populated cities of Colombia. An analytical method based on solid-phase extraction (SPE) of the sample followed by measurement by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) was developed and validated for this purpose. Five monitoring campaigns were performed in each reservoir, collecting samples from 7 sites (LF) and 10 sites (RG) at 3 different depths of the water column...
January 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28098722/prevalence-of-preservatives-across-all-product-types-in-the-contact-allergen-management-program
#12
Kevin M Beene, Andrew Scheman, Dave Severson, Margo J Reeder
BACKGROUND: Preservatives are known causes of allergic contact dermatitis. OBJECTIVE: The aim of this study was to determine the prevalence of preservatives in each product category in the Contact Allergen Management Program and compare prevalence with reported rates of allergic contact dermatitis. METHODS: Contact Allergen Management Program product information was queried based on the 53 approved preservatives for cosmetic products by the European Union and Association of Southeast Asian Nations plus 5 additional preservatives used in US products...
January 2017: Dermatitis
https://www.readbyqxmd.com/read/28098264/assessment-of-coulometric-array-electrochemical-detection-coupled-with-hplc-uv-for-the-absolute-quantitation-of-pharmaceuticals
#13
Michael B Hicks, Leah Salituro, Ian Mangion, Wes Schafer, Rong Xiang, Xiaoyi Gong, Christopher J Welch
The use of a coulometric array detector in tandem with HPLC-UV was evaluated for the absolute quantitation of pharmaceutical compounds without standards, an important capability gap in contemporary pharmaceutical research and development. The high-efficiency LC flow-through electrochemical detector system allows for the rapid evaluation of up to 16 different potentials, aiding in the identification and quantitation of electrochemically reactive species. By quantifying the number of electrons added or removed from an analyte during its passage through the detector, the number of moles of the analyte can be established...
January 18, 2017: Analyst
https://www.readbyqxmd.com/read/28061343/maternal-urinary-paraben-levels-and-offspring-size-at-birth-from-a-chinese-birth-cohort
#14
Chuansha Wu, Wenqian Huo, Yuanyuan Li, Bin Zhang, Yanjian Wan, Tongzhang Zheng, Aifen Zhou, Zhong Chen, Minzheng Qian, Yingshuang Zhu, Yangqian Jiang, Hongxiu Liu, Jie Hu, Xi Chen, Bing Xu, Wei Xia, Shunqing Xu
BACKGROUND: Parabens are suspected to impair fetal growth because of their endocrine disrupting effects. Epidemiological studies regarding the effects of prenatal exposure to parabens on birth outcomes are limited. OBJECTIVES: Our aim was to evaluate the association between prenatal paraben exposure and size of infants at birth. METHODS: Within the longitudinal Healthy Baby Cohort (HBC) in Hubei Province, China, we randomly selected 1006 mother-infant pairs recruited in Wuhan City in 2014...
April 2017: Chemosphere
https://www.readbyqxmd.com/read/28034559/urinary-paraben-concentrations-and-their-associations-with-anthropometric-measures-of-children-aged-3-years
#15
Jianqiu Guo, Chunhua Wu, Dasheng Lu, Shuai Jiang, Weijiu Liang, Xiuli Chang, Hao Xu, Guoquan Wang, Zhijun Zhou
Parabens, known as ubiquitous preservatives, have been linked to adverse health outcomes in humans. This study aimed to examine urinary paraben concentrations of children at 3 years of age and evaluate their associations with anthropometric parameters. Urinary parabens including methylparaben (MeP), ethylparaben (EtP), propylparaben (PrP), butylparaben (BuP) and benzylparaben (BeP) were measured among 436 children in a birth cohort using gas chromatography with tandem mass spectrometry. Generalized linear models were performed to evaluate associations of paraben exposures with age- and sex-specific z scores, including weight, height, weight for height and body mass index...
March 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28032288/removal-of-parabens-and-their-chlorinated-by-products-by-periphyton-influence-of-light-and-temperature
#16
Chaofeng Song, Hongjuan Hu, Hongyi Ao, Yonghong Wu, Chenxi Wu
The extensive use of parabens as preservatives in food and pharmaceuticals and personal care products results in frequent detection of their residuals in aquatic environment. In this work, the adsorption and removal of four parabens (methyl-, ethyl-, propyl-, and butyl-paraben) and two chlorinated methyl-parabens (CMPs) by periphyton were studied. Characteristics of the periphyton were identified to explore the possible relationship between paraben removal and periphyton properties. Results showed that linear adsorption coefficients (K d) vary from 554...
December 29, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28024590/a-novel-electrochemical-platform-based-on-carbon-nanofibers-and-tri-metallic-nanoparticles-of-gold-nickel-and-cobalt-for-the-quantification-of-ethyl-paraben
#17
Aysegul Kutluay Baytak, Tugce Teker, Sehriban Duzmen, Mehmet Aslanoglu
A composite of carbon nanofibers (CNFs) and tri-metallic nanoparticles of gold, cobalt and nickel were used for the preparation of a novel voltammetric platform. The proposed voltammetric platform was utilized for quantifying ethyl paraben (EPB) in pharmaceutical and cosmetic products. The electrode layers were characterized by utilizing X-ray diffraction method (XRD) and Fourier transform infrared spectroscopy (FTIR). The electrode system, (Au-Ni-Co)NPs-CNFs/GCE, exhibited high catalytic activity and enhanced the electrochemical behaviour of EPB compared with several other electrodes...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28010737/a-new-generation-of-nano-structured-supramolecular-solvents-based-on-propanol-gemini-surfactant-for-liquid-phase-microextraction
#18
Neda Feizi, Yadollah Yamini, Morteza Moradi, Meghdad Karimi, Qamar Salamat, Hatam Amanzadeh
A new supramolecular solvent (SUPRAS) made up of aggregates of gemini surfactant was introduced. A microextraction method, based on the SUPRAS followed with high performance liquid chromatography-ultraviolet detection, was applied for the determination of parabens in cosmetics, beverages and water samples. A SUPRAS is a nano-structured liquid made up of surfactant aggregates synthesized through a self-assembly process. In the present work, a new gemini-based SUPRAS was introduced. Methyl paraben (MP), ethyl paraben (EP), and propyl paraben (PP) were extracted on the basis of π-cation and Van der Waals interactions into the SUPRAS...
February 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28002779/degradation-of-chlorinated-paraben-by-integrated-irradiation-and-biological-treatment-process
#19
Shizong Wang, Jianlong Wang, Yuliang Sun
Chlorinated paraben, namely, methyl 3, 5-dichloro-4-hydroxybenzoate (MDHB) is the by-product of chlorination disinfection of paraben and frequently detected in the aquatic environments, which exhibited higher persistence and toxicity than paraben itself. In this paper, the combined irradiation and biological treatment process was employed to investigate the removal of MDHB from aqueous solution. The results showed that the removal efficiency of MDHB and total organic carbon (TOC) by irradiation process increased with radiation dose no matter what the initial concentration of MDHB was...
March 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/27995640/genotoxic-risk-of-ethyl-paraben-could-be-related-to-telomere-shortening
#20
F Finot, A Kaddour, L Morat, I Mouche, N Zaguia, C Cuceu, D Souverville, S Négrault, O Cariou, A Essahli, N Prigent, J Saul, F Paillard, L Heidingsfelder, P Lafouge, M Al Jawhari, W M Hempel, M El May, B Colicchio, A Dieterlen, E Jeandidier, L Sabatier, J Clements, R M'Kacher
The ability of parabens to promote the appearance of multiple cancer hallmarks in breast epithelium cells provides grounds for regulatory review of the implication of the presence of parabens in human breast tissue. It is well documented that telomere dysfunction plays a significant role in the initiation of genomic instability during carcinogenesis in human breast cancer. In the present study, we evaluated the genotoxic effect of ethyl 4-hydroxybenzoate (ethyl-paraben), with and without metabolic activation (S9), in studies following OECD guidelines...
December 20, 2016: Journal of Applied Toxicology: JAT
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