keyword
MENU ▼
Read by QxMD icon Read
search

Paraben

keyword
https://www.readbyqxmd.com/read/28535462/pharmaceutical-substances-in-ambient-particulates-a-preliminary-assessment
#1
Angelo Cecinato, Paola Romagnoli, Mattia Perilli, Catia Balducci
Till now, no attention has been paid to pharmaceuticals (PCs) in the air, though they are known to affect waters, soils, foods and biota. This paper describes the first attempt to characterize the PC occurrence in the air. Airborne particulates (PM10 or PM2.5 fractions, from Amsterdam, Netherland, Rome and Rende, Italy) were sampled on quartz fiber filter by means of pumping systems operating at medium-volume conditions (16 or 38.5 L min(-1)). The samples were solvent extracted through sonication with a dichloromethane:acetone:methanol mixture and reduced close to dryness; three fractions of the residue were separated through column chromatography; they comprised non polar, low polar and very polar organic compounds, respectively, and PCs were in the third one...
May 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28527915/methylparaben-and-butylparaben-alter-multipotent-mesenchymal-stem-cell-fates-towards-adipocyte-lineage
#2
Pan Hu, Haley Overby, Emily Heal, Shu Wang, Jiangang Chen, Chwan-Li Shen, Ling Zhao
Paraben esters and their salts are widely used as preservatives in cosmetics, personal care products, pharmaceuticals, and foods. We previously reported that parabens promoted adipocyte differentiation in vitro and increased adiposity but suppressed serum marker of bone formation in vivo. Here, we investigated the effects of parabens (methylparaben and butylparaben) on modulating cell fate of multipotent stem cell line C3H10T1/2. Both parabens modulated adipogenic, osteogenic, and chondrogenic differentiation of C3H10T1/2 cells in vitro...
May 17, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28527332/determination-of-parabens-in-human-urine-by-optimal-ultrasound-assisted-emulsification-microextraction-and-on-line-acetylation-gas-chromatography-mass-spectrometry
#3
Zhou Hui-Ting, Erica M C Ding, Wang-Hsien Ding
An effective and solvent-less method for the rapid determination of four commonly detected parabens (methyl-, ethyl-, propyl- and butyl-) in human urine samples is described. This method employed ultrasound-assisted emulsification microextraction (USAEME) before identification and quantitation of the parabens via on-line acetylation gas chromatography-mass spectrometry (GC-MS). Urine samples were enzymatically de-conjugated with β-glucuronidase and then extracted by an optimal USAEME procedure for the measurement of total concentrations of target analytes...
May 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28526231/exposures-to-endocrine-disrupting-chemicals-in-consumer-products-a-guide-for-pediatricians
#4
Katelyn H Wong, Timur S Durrani
Endocrine disrupting chemicals, a group of exogenous chemicals that can interfere with hormone action in the body, have been implicated in disrupting endocrine function, which negatively affects human health and development. Endocrine disrupting chemicals are ubiquitously detected in consumer products, foods, beverages, personal care products, and household cleaning products. Due to concerns about their negative effects on human health, several professional health provider societies have recommended the reduction of common endocrine disrupting chemical exposures...
May 16, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28525834/exposure-to-phenols-parabens-and-uv-filters-associations-with-loss-of-function-mutations-in-the-filaggrin-gene-in-men-from-the-general-population
#5
Ulla N Joensen, Niels Jørgensen, Jacob P Thyssen, Jørgen Holm Petersen, Pal B Szecsi, Steen Stender, Anne-Maria Andersson, Niels E Skakkebæk, Hanne Frederiksen
BACKGROUND: Filaggrin is an epidermal protein that is important for normal skin barrier functions. Up to 10% of Europeans and Asians carry filaggrin gene (FLG) loss-of function mutations that appear to facilitate trans-epidermal penetration of certain chemicals. We previously showed that mutation carriers have higher internal exposure to certain phthalates, compared to controls, and hypothesized that they could have increased trans-epidermal penetration of other chemicals. OBJECTIVES: We investigated exposure to non-persistent chemicals in young Danish men with and without FLG mutations...
May 16, 2017: Environment International
https://www.readbyqxmd.com/read/28525533/phenol-concentrations-during-childhood-and-subsequent-measures-of-adiposity-among-young-girls
#6
Andrea L Deierlein, Mary S Wolff, Ashley Pajak, Susan M Pinney, Gayle C Windham, Maida P Galvez, Michael Rybak, Antonia M Calafat, Lawrence H Kushi, Frank M Biro, Susan L Teitelbaum
Phenolic compounds represent a class of environmental chemicals with potential endocrine disrupting capabilities. We investigated longitudinal associations of childhood exposures to phenols, from both man-made and natural sources, and subsequent measures of adiposity among girls enrolled in The Breast Cancer and Environment Research Program, 2004-2007. Baseline (ages 6-8 years) urinary concentrations were obtained for creatinine and phenol metabolites: enterolactone, genistein, daidzein, benzophenone-3, bisphenol A, sum of parabens (methyl, ethyl, and propyl parabens), 2,5-dichlorophenol, and triclosan...
May 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28502468/magnetically-assisted-matrix-solid-phase-dispersion-for-extraction-of-parabens-from-breast-milks
#7
Mina Fotouhi, Shahram Seidi, Maryam Shanehsaz, Mohammad Taghi Naseri
In the present work, magnetically assisted matrix solid phase dispersion (MA-MSPD) was used as an efficient solid phase extraction method. MA-MSPD followed by a dispersive liquid-liquid microextraction (DLLME) was applied for determination of parabens in breast milks. The analysis were performed using LC-UV and LC-MS/MS. Poly(indole-thiophene) coated magnetic graphene oxide (MGO@PIT) was synthesized, characterized and used as the sorbent. Na2SO4 was used as the drying salt as well as matrix dispersing agent...
May 5, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28501195/recycling-polymer-residues-to-synthesize-magnetic-nanocomposites-for-dispersive-micro-solid-phase-extraction
#8
Hoda Ghambari, Emilia M Reyes-Gallardo, Rafael Lucena, Mohammad Saraji, Soledad Cárdenas
The ubiquitous presence of plastics, an obvious consequence of their usefulness and low price, has turned them into a problem of environmental and safety concern. The new plastic economy, an initiative recently launched by the World Economic Forum and Ellen MacArthur Foundation, with analytical support from McKinsey & Company, promotes a change in the use of plastic worldwide around three main pillars: redesign, reusing and recycling. Recycled plastics, with the aim of extending their life spam, can be used to synthesize materials for analytical purposes...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28497013/racial-ethnic-disparities-in-environmental-endocrine-disrupting-chemicals-and-women-s-reproductive-health-outcomes-epidemiological-examples-across-the-life-course
#9
Tamarra M James-Todd, Yu-Han Chiu, Ami R Zota
Disparities in women's reproductive health outcomes across the life course have been well-documented. Endocrine disrupting chemicals may be one factor driving disparities, as studies suggest exposure to certain environmental endocrine disrupting chemicals, such as certain phthalates, bisphenol A, parabens and polybrominated diphenyl ethers are higher in non-whites. Yet, a limited amount of research has focused on these chemical exposures as a potential mediator of racial/ethnic differences in women's reproductive health outcomes, such as pubertal development, fibroids, infertility, and pregnancy complications...
June 2016: Current Epidemiology Reports
https://www.readbyqxmd.com/read/28478814/fragrance-compounds-the-wolves-in-sheep-s-clothings
#10
Seema Patel
In the past few decades, synthetic fragrance compounds have become ubiquitous components of personal care and household cleaning products. Overwhelming consumerism trends have led to the excess usage of these chemicals. It has been observed that this fragrance-laden unhealthy lifestyle runs parallel with the unprecedented rates of diabetes, cancer, neural ailments, teratogenicity, and transgender instances. The link between fragrances as and the multiplicity of pathogens remained latent for decades. However, now this health hazard and its role in homeostasis breakdown is getting attention...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28468729/trapping-multiple-dual-mode-centrifugal-partition-chromatography-for-the-separation-of-intermediately-eluting-components-throughput-maximization-strategy
#11
Raena Morley, Mirjana Minceva
Trapping multiple dual mode centrifugal partition chromatography (trapping MDM CPC) is an alternative to isocratic pulse injections for the separation of intermediately-eluting components from complex mixtures using liquid-liquid chromatography. In this work, a throughput maximization strategy is developed and validated to investigate the full potential of trapping MDM CPC as a preparative technique. In the proposed approach, shake flask and stationary phase retention experiments are used to determine the maximum feed concentration and flow rate, respectively...
April 20, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28466639/side-chains-of-parabens-modulate-antiandrogenic-activity-in-vitro-and-molecular-docking-studies
#12
Keke Ding, Xiaotian Kong, Jingpeng Wang, Liping Lu, Wenfang Zhou, Tingjie Zhan, Chunlong Zhang, Shulin Zhuang
Parabens have been widely used in packaged foods, pharmaceuticals, and personal-care products. Considering their potential hydrolysis, we herein investigated structural features leading to the disruption of human androgen receptor (AR) and whether hydrolysis could alleviate such effects using the recombinant yeast two-hybrid assay. Parabens with an aryloxy side chain such as benzyl paraben and phenyl paraben have the strongest antiandrogenic activity. The antiandrogenic activity of parabens with alkyloxyl side chains decreases as the side chain length increases from 1 to 4, and no antiandrogenic effect occurred for heptyl, octyl, and dodecyl parabens with the number of alkoxyl carbon atoms longer than 7...
May 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28421984/stability-indicating-uplc-method-for-the-estimation-of-nadifloxacin-terbinafine-hydrochloride-mometasone-furoate-methyl-paraben-and-propyl-paraben-in-topical-pharmaceutical-dosage-form
#13
Dileep M Bhosale, Anna Pratima G Nikalje
A novel and simple ultra-performance LC method was developed for the estimation of nadifloxacin (NAD), terbinafine hydrochloride (TBH), mometasone furoate (MMF), methyl paraben (MP), and propyl paraben (PP) in a topical pharmaceutical dosage formulation. The analysis was carried out on a Waters Acquity UPLC ethylene bridged hybrid C18 column (50 × 2.1 mm, 1.7 μm) with a flow rate of 0.4 mL/min in gradient mode at a wavelength of 255 nm. Elution of all components was achieved within 9 min. The retention times of MP, NAD, PP, TBH, and MMF were observed at 1...
April 18, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28416215/stir-bar-sorptive-extraction-and-liquid-chromatography-tandem-mass-spectrometry-determination-of-polar-and-non-polar-emerging-and-priority-pollutants-in-environmental-waters
#14
Irene Aparicio, Julia Martín, Juan Luis Santos, José Luis Malvar, Esteban Alonso
An analytical method based on stir bar sorptive extraction (SBSE) was developed and validated for the determination of environmental concern pollutants in environmental waters by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Target compounds include six water and oil repellents (perfluorinated compounds), four preservatives (butylated hydroxytoluene and three parabens), two plasticizers (bisphenol A and di(2-ethylhexyl)phthalate), seven surfactants (four linear alkylbenzene sulfonates, nonylphenol and two nonylphenol ethoxylates), a flame retardant (hexabromocyclododecane), four hormones, fourteen pharmaceutical compounds, an UV-filter (2-ethylhexyl 4-methoxycinnamate) and nine pesticides...
April 7, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28408822/negatively-charged-silver-nanoparticles-with-potent-antibacterial-activity-and-reduced-toxicity-for-pharmaceutical-preparations
#15
Lucia Salvioni, Elisabetta Galbiati, Veronica Collico, Giulia Alessio, Svetlana Avvakumova, Fabio Corsi, Paolo Tortora, Davide Prosperi, Miriam Colombo
BACKGROUND: The discovery of new solutions with antibacterial activity as efficient and safe alternatives to common preservatives (such as parabens) and to combat emerging infections and drug-resistant bacterial pathogens is highly expected in cosmetics and pharmaceutics. Colloidal silver nanoparticles (NPs) are attracting interest as novel effective antimicrobial agents for the prevention of several infectious diseases. METHODS: Water-soluble, negatively charged silver nanoparticles (AgNPs) were synthesized by reduction with citric and tannic acid and characterized by transmission electron microscopy, dynamic light scattering, zeta potential, differential centrifuge sedimentation, and ultraviolet-visible spectroscopy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28390971/butyl-paraben-and-propyl-paraben-modulate-bisphenol-a-and-estradiol-concentrations-in-female-and-male-mice
#16
Tyler Pollock, Rachel E Weaver, Ramtin Ghasemi, Denys deCatanzaro
People are routinely exposed to the antimicrobial preservatives butyl paraben (BP) and propyl paraben (PP), as well as the monomer of polycarbonate plastics, bisphenol A (BPA). These chemicals are reliably detected in human urine and potentially interact. We investigated whether BP or PP exposure can modulate the concentrations of (14)C-BPA and 17β-estradiol (E2). Female and male CF1 mice were each given a subcutaneous injection of oil containing 0 (vehicle), 1, 3, or 9mg BP or PP, then given a dietary supplement containing 50μg/kg (14)C-BPA...
April 5, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28382686/methylparaben-induced-decrease-in-collagen-production-and-viability-of-cultured-human-dermal-fibroblasts
#17
Natalia Majewska, Ilona Zaręba, Arkadiusz Surażyński, Anna Galicka
Parabens owing to their many advantageous properties are widely applied in cosmetics, food products and pharmaceuticals. However, recent research results have shown that they possess the ability to accumulate in the human body and exert many adverse effects. In this study, the impact of methylparaben (MP) as the most frequently used preservative in cosmetics, on human dermal fibroblasts and collagen production was evaluated. In cells treated with 0.01, 0.03 and 0.05% MP a dose-dependent decrease in collagen biosynthesis was revealed, which was positively correlated with the activity of prolidase responsible for the recovery of proline...
April 6, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28379057/metoclopramide-nasal-spray-in-vitro-evaluation-and-in-vivo-pharmacokinetic-studies-in-dogs
#18
Ying Li, Xianpeng Fan, Wanqing Li, Peng Yang, Hui Zhang, Daoquan Tang, Xiaoxin Yin, Jianxu Sun, Aiping Zheng
Metoclopramide (MCP) can effectively alleviate motion sickness-caused nausea and vomiting. Nasal administration offers the greatest patient compliance. It is suitable for self-administration and offers rapid and complete absorption, no first-pass effects, and high bioavailability. In present study, a MCP nasal spray was prepared and evaluated in vitro and in vivo. Nasal cilia toxicity of Bufo toads was used to screen the preservative types and concentrations. Rabbit nasal mucosa was used to evaluate the mucosa permeability of different MCP nasal sprays with different penetration enhancers and preservative...
April 5, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28376394/co-metabolic-enhancement-of-organic-removal-from-waste-water-in-the-presence-of-high-levels-of-alkyl-paraben-constituents-of-cosmetic-and-personal-care-products
#19
Chihhao Fan, Shin-Chih Wang
The enhanced removal of organic material from municipal waste water containing 50 mg/L of chemical oxygen demand and a given amount of alkyl paraben using a biofilm system was investigated. The parabens used were methyl, ethyl, and propyl paraben. The experiments were conducted at influent paraben concentrations of 10 and 50 mg/L. The influent pH was measured around 4.6 because of paraben hydrolysis. The effluent pH increased due to hydrogen consumption and small molecular acid generation. The higher removal rates were observed for the paraben with longer alkyl chains, which were more hydrophobic and capable of penetrating into microbial cells...
July 2017: Chemosphere
https://www.readbyqxmd.com/read/28370680/rapid-and-sensitive-determination-of-multiple-endocrine-disrupting-chemicals-by-ultrasound-assisted-in-situ-derivatization-dispersive-liquid-liquid-microextraction-coupled-with-uhplc-ms-ms
#20
Na Wei, Zhenjia Zheng, Yuhua Wang, Yanduo Tao, Yun Shao, Shuyun Zhu, Jinmao You, Xian-En Zhao
RATIONALE: Endocrine disrupting chemicals (EDCs) in environment samples and food stuffs are an increasing serious public health issue due to their potency to interfere and deregulate several aspects of the endocrine system. Because of their extremely low abundance, it remains a challenging task to develop a sensitive detection method. METHODS: 4'-Carbonyl chloride rosamine (CCR) was used as a derivatization reagent for EDCs for the first time. A new ultrasound-assisted in situ derivatization-dispersive liquid-liquid microextraction (UA-DLLME with in situ derivatization) method for multiple EDCs including five estrogens, two alkylphenols, eight bisphenols, seven parabens and triclosan coupled with ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) has been developed and validated...
March 31, 2017: Rapid Communications in Mass Spectrometry: RCM
keyword
keyword
21127
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"