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https://www.readbyqxmd.com/read/28346910/occurrence-temporal-variation-and-estrogenic-burden-of-five-parabens-in-sewage-sludge-collected-across-the-united-states
#1
Jing Chen, Benny F G Pycke, Bruce J Brownawell, Chad A Kinney, Edward T Furlong, Dana W Kolpin, Rolf U Halden
Five parabens used as preservatives in pharmaceuticals and personal care products (PPCPs) were measured in sewage sludges collected at 14 U.S. wastewater treatment plants (WWTPs) located in nine states. Detected concentration ranges (ng/g, dry weight) and frequencies were as follows: methyl paraben (15.9 to 203.0; 100%), propyl paraben (0.5 to 7.7; 100%), ethyl paraben (<0.6 to 2.6; 63%), butyl paraben (<0.4 to 4.3; 42%) and benzyl paraben (<0.4 to 3.3; 26%). The estrogenicity inherent to the sum of parabens detected in sewage sludge (ranging from 10...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28342347/assumed-non-persistent-environmental-chemicals-in-human-adipose-tissue-matrix-stability-and-correlation-with-levels-measured-in-urine-and-serum
#2
F Artacho-Cordón, J P Arrebola, O Nielsen, P Hernández, N E Skakkebaek, M F Fernández, A M Andersson, N Olea, H Frederiksen
The aim of this study was to (1) optimize a method for the measurement of parabens and phenols in adipose tissue, (2) evaluate the stability of chemical residues in adipose tissue samples, and (3) study correlations of these compounds in urine, serum, and adipose tissue. Samples were obtained from adults undergoing trauma surgery. Nine phenols and seven parabens were determined by isotope diluted TurboFlow-LC-MS/MS. The analytical method showed good accuracy and precision. Limits of detection (LOD) for parabens and phenols ranged from 0...
March 22, 2017: Environmental Research
https://www.readbyqxmd.com/read/28339377/stability-of-clindamycin-hydrochloride-in-pcca-base-suspendit
#3
Yashoda V Pramar, Richard A Graves, Grace A Ledet, Kelly V Phan, Levon A Bostanian, Tarun K Mandal
Clindamycin is an effective antibiotic in the treatment of infections caused by certain gram-positive and gram-negative anaerobic microorganisms. While manufactured forms of the drug for pediatric use are available, there are instances when a compounded liquid dosage form is essential to meet unique patient needs. The purpose of this study was to determine the chemical stability of clindamycin hydrochloride in the PCCA base SuspendIt, a sugar-free, paraben- free, dye-free, and gluten-free thixotropic vehicle containing a natural sweetener obtained from the monk fruit...
September 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28338538/allergenic-ingredients-in-facial-wet-wipes
#4
Kelly A Aschenbeck, Erin M Warshaw
BACKGROUND: Allergic contact dermatitis commonly occurs on the face. Facial cleansing wipes may be an underrecognized source of allergens. OBJECTIVE: The aim of this study was to determine the frequency of potentially allergenic ingredients in facial wet wipes. METHODS: Ingredient lists from name brand and generic facial wipes from 4 large retailers were analyzed. RESULTS: In the 178 facial wipes examined, a total of 485 ingredients were identified (average, 16...
March 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/28338537/allergenic-ingredients-in-personal-hygiene-wet-wipes
#5
Kelly A Aschenbeck, Erin M Warshaw
BACKGROUND: Wet wipes are a significant allergen source for anogenital allergic contact dermatitis. OBJECTIVE: The aim of the study was to calculate the frequency of potentially allergenic ingredients in personal hygiene wet wipes. METHODS: Ingredient lists from brand name and generic personal hygiene wet wipes from 4 large retailers were compiled. RESULTS: In the 54 personal hygiene wet wipes evaluated, a total of 132 ingredients were identified (average of 11...
March 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/28324817/developmental-toxicity-and-induction-of-vitellogenin-in-embryo-larval-stages-of-zebrafish-danio-rerio-exposed-to-methyl-paraben
#6
Vrinda Yatin Dambal, Karthikeyan Ponnien Selvan, Christy Lite, S Barathi, Winkins Santosh
MethylParaben (MP), a methyl ester of p-hydroxybenzoic acid, is used as an anti-microbial preservative in foods, drugs and cosmetics for decades. It enters the aquatic environment, and can have toxic effects on aquatic organisms. Little is known on the developmental toxicity of MP exposure to zebrafish during early life stages. In this study, the developmental effects of MP were evaluated in embryo-larval zebrafish (at concentrations ranging from 100μM, 200μM, 400µM, 800μM and 1000μM for 96h post fertilization (hpf)...
March 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28318231/paraben-concentrations-in-maternal-urine-and-breast-milk-and-its-association-with-personal-care-product-use
#7
Mandy Fisher, Susan MacPherson, Joseph M Braun, Russ Hauser, Mark Walker, Mark Feeley, Ranjeeta Mallick, René Bérubé, Tye E Arbuckle
Parabens are broad-spectrum antimicrobial preservatives and fragrances used in a wide range of personal care products, pharmaceuticals, and food providing the opportunity for people to be exposed on a daily basis. In 2009-2010, 80 pregnant women from Ottawa Canada participated in the Plastics and Personal-Care Product Use in Pregnancy (P4) Study. A subset of women (n = 31) who provided multiple spot urine samples (n = 542) collected over two 24-h periods had their samples analyzed for methylparaben (MP), n-propylparaben (PP), ethylparaben (EP), butylparaben (BP), isobutylparaben (IBP), and benzylparaben (BzP)...
March 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28315385/a-study-on-the-in-vitro-percutaneous-absorption-of-silver-nanoparticles-in-combination-with-aluminum-chloride-methyl-paraben-or-di-n-butyl-phthalate
#8
Katarzyna Domeradzka-Gajda, Marek Nocuń, Joanna Roszak, Beata Janasik, C Derrick Quarles, Wojciech Wąsowicz, Jarosław Grobelny, Emilia Tomaszewska, Grzegorz Celichowski, Katarzyna Ranoszek-Soliwoda, Małgorzata Cieślak, Dorota Puchowicz, Jhanis J Gonzalez, Richard E Russo, Maciej Stępnik
Some reports indicate that the silver released from dermally applied products containing silver nanoparticles (AgNP) (e.g. wound dressings or cosmetics) can penetrate the skin, particularly if damaged. AgNP were also shown to have cytotoxic and genotoxic activity. In the present study percutaneous absorption of AgNP of two different nominal sizes (Ag15nm or Ag45nm by STEM) and surface modification, i.e. citrate or PEG stabilized nanoparticles, in combination with cosmetic ingredients, i.e. aluminum chloride (AlCl3), methyl paraben (MPB), or di-n-butyl phthalate (DBPH) was assessed using in vitro model based on dermatomed pig skin...
March 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28306542/biomonitoring-of-danish-school-children-and-mothers-including-biomarkers-of-pbde-and-glyphosate
#9
Lisbeth E Knudsen, Pernille Winton Hansen, Seher Mizrak, Heidi K Hansen, Thit A Mørck, Flemming Nielsen, Volkert Siersma, Line Mathiesen
BACKGROUND: The Danish part of the large European Human biomonitoring pilot project Demonstration of a study to Coordinate and Perform Human biomonitoring on a European Scale (DEMOCOPHES) investigated the urine, hair and blood concentrations of 66 different environmental chemicals in a group of 145 Danish school children aged 6-11 years and their mothers from rural and urban areas in autumn 2011. Some - but not all - results were published; however, the concurrence of the chemicals has not been assessed...
March 17, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28297055/any-use-for-alternative-lock-solutions-in-the-prevention-of-catheter-related-blood-stream-infections
#10
Laura Labriola, Jean-Michel Pochet
The prevention of catheter-related blood stream infections (CRBSI) in hemodialysis (HD) patients remains a challenge because of high morbidity and mortality associated to CRBSI. Alternative locking solutions (ALS) containing an antithrombotic substance with additional antimicrobial or antibiofilm properties (citrate, ethylenediaminetetraacetic acid [EDTA], 70% ethanol, thrombolytics) with or without the addition of molecules with specific antimicrobial activity (antibiotics, taurolidine, paraben-methylene-blue) has been proposed with the aim to prevent or eradicate intraluminal biofilm colonization and subsequent CRBSI...
March 6, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28284644/suitability-of-pharmaceuticals-and-personal-care-products-ppcps-and-artificial-sweeteners-ass-as-wastewater-indicators-in-the-pearl-river-delta-south-china
#11
Yuan-Yuan Yang, Wang-Rong Liu, You-Sheng Liu, Jian-Liang Zhao, Qian-Qian Zhang, Min Zhang, Jin-Na Zhang, Yu-Xia Jiang, Li-Juan Zhang, Guang-Guo Ying
Wastewater indicator is a useful tool for evaluating the wastewater impact on natural water, but there is little information about the suitability of wastewater indicators for different regions. This study aimed to select suitable wastewater indicators in the Pearl River Delta region, south China by screening a range of wastewater related organic compounds. The screening campaign was carried out by investigating the occurrence and removal efficiencies of 93 pharmaceuticals and personal care products (PPCPs) and 5 artificial sweeteners (ASs) in nine wastewater treatment plants (WWTPs) located in the region, and the occurrence of these target compounds in the contaminated and clean surface water of the Pearl River...
March 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28281298/children-with-atopic-dermatitis-and-frequent-emollient-use-have-increased-urinary-levels-of-low-molecular-weight-phthalate-metabolites-and-parabens
#12
Line E K Overgaard, Katharina M Main, Hanne Frederiksen, Steen Stender, Pal B Szecsi, Hywel C Williams, Jacob P Thyssen
BACKGROUND: Parabens may be added to cosmetic and personal care products for preservation purposes. Low-molecular weight (LMW) phthalate diesters function as plasticizers, fixatives or solvents in such products, but may also be found in small quantities as contaminants from plastic containers. OBJECTIVE: To evaluate the association between emollient use, atopic dermatitis and FLG mutations, respectively, with urinary concentrations of phthalate metabolites and parabens in Danish children...
March 9, 2017: Allergy
https://www.readbyqxmd.com/read/28277177/simultaneous-determination-of-nine-preservatives-in-food-by-liquid-chromatography-with-the-aid-of-coagulant-in-the-clean-up-process
#13
Jun Sugiura, Masahiro Nakajima
A simple HPLC method was developed for the simultaneous analysis of nine preservatives in food including benzoic acid, sorbic acid, dehydroacetic acid, methyl paraben, ethyl paraben, isopropyl paraben, propyl paraben, isobutyl paraben and butyl paraben. Samples were extracted with 60 v/v% methanol containing poly-aluminium chloride (PAC) and sodium hydroxide prior to analysis. PAC, which is normally used as a coagulant, was successfully applied to remove interfering substances from the samples. The method showed good linearity with coefficients of determination higher than 0...
February 22, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28213243/multi-residue-analysis-of-36-priority-and-emerging-pollutants-in-marine-echinoderms-holothuria-tubulosa-and-marine-sediments-by-solid-liquid-extraction-followed-by-dispersive-solid-phase-extraction-and-liquid-chromatography-tandem-mass-spectrometry-analysis
#14
J Martín, A Zafra-Gómez, F Hidalgo, A J Ibáñez-Yuste, E Alonso, J L Vilchez
Marine echinoderms are filter-feeding invertebrates widely distributed along the coasts, and which are therefore extensively exposed to anthropogenic xenobiotics. They can serve as good sentinels for monitoring a large variety of contaminants in marine ecosystems. In this context, a multi-residue analytical method has been validated and applied to Holothuria tubulosa specimens and marine sediments for the determination of 36 organic compounds, which belong to some of the most problematic groups of emerging and priority pollutants (perfluoroalkyl compounds, estrogens, parabens, benzophenones, plasticizers, surfactants, brominated flame retardants and alkylphenols)...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28208728/parabens-accelerate-ovarian-dysfunction-in-a-4-vinylcyclohexene-diepoxide-induced-ovarian-failure-model
#15
Jae-Hwan Lee, Myeongho Lee, Changhwan Ahn, Hee Young Kang, Dinh Nam Tran, Eui-Bae Jeung
Parabens are widely used preservatives in basic necessities such as cosmetic and pharmaceutical products. In previous studies, xenoestrogenic actions of parabens were reported in an immature rat model and a rat pituitary cell line (GH3 cells). The relationship between parabens and ovarian failure has not been described. In the present study, the influence of parabens on ovarian folliculogenesis and steroidogenesis was investigated. A disruptor of ovarian small pre-antral follicles, 4-vinylcyclohexene diepoxide (VCD, 40 mg/kg), was used to induce premature ovarian failure (POF)...
February 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28194803/the-current-spectrum-of-contact-sensitization-in-patients-with-chronic-leg-ulcers-or-stasis-dermatitis%C3%A2-%C3%A2-new-data-from-the-information-network-of-departments-of-dermatology-ivdk
#16
Cornelia Erfurt-Berge, Johannes Geier, Vera Mahler
BACKGROUND: Patients with lower leg dermatitis, chronic venous insufficiency or chronic leg ulcers have a high prevalence of contact sensitization. OBJECTIVES: To identify the current spectrum of contact allergens in these patients. PATIENTS AND METHODS: Data of the Information Network of Departments of Dermatology on 5264 patients with the above diagnoses from the years 2003 to 2014 (study group) were compared with data on 4881 corresponding patients from 1994 to 2003 (historical control group) and with a current control group without these diagnoses (n = 55 510)...
February 14, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28181406/endocrine-disrupting-effects-of-methylparaben-on-the-adult-gerbil-prostate
#17
Janaína R Costa, Mônica S Campos, Rodrigo F Lima, Liana S Gomes, Mara R Marques, Sebastião R Taboga, Manoel F Biancardi, Pedro V A Brito, Fernanda C A Santos
Parabens are xenoestrogens widely employed in cosmetics, foodstuffs, and pharmaceutical products. These chemicals are known to disrupt hormone-dependent organs, due to their binding affinity for hormonal receptors. Although recent studies have evaluated the endocrine-disrupting potential of parabens in several reproductive organs, few have investigated the effects of these chemicals in the prostate. The aim of this work was to evaluate the effects of oral exposure to methylparaben (500 mg/kg/day) for 3, 7, and 21 days on male and female adult gerbil prostate...
February 9, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28159478/identification-of-exposure-to-environmental-chemicals-in-children-and-older-adults-using-human-biomonitoring-data-sorted-by-age-results-from-a-literature-review
#18
Judy Choi, Lisbeth E Knudsen, Seher Mizrak, Anke Joas
Human biomonitoring (HBM) provides the tools for exposure assessment by direct measurements of biological specimens such as blood and urine. HBM can identify new chemical exposures, trends and changes in exposure, establish distribution of exposure among the general population, and identify vulnerable groups and populations with distinct exposures such as children and older adults. The objective of this review is to demonstrate the use of HBM to identify environmental chemicals that might be of concern for children or older adults due to higher body burden...
December 21, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28157063/safe-excipient-exposure-in-neonates-and-small-children-protocol-for-the-seen-project
#19
Kristine Svinning Valeur, Steen Axel Hertel, Kaare Engell Lundstrøm, Helle Holst
INTRODUCTION: The pharmacokinetics of excipients in neonates differs from that of older children. In a recent pan--European survey, two thirds of neonates received at least one potentially harmful excipient, such as ethanol and benzoates. The content of sweeteners varied by route of administration (more common by enteral than parenteral route), and regional differences were revealed. The survey did not identify if the content of excipients was more pronounced in medications prescribed for specific medical diseases, e...
February 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28153288/a-simple-and-fast-double-flow-microfluidic-device-based-liquid-phase-microextraction-df-%C3%A2%C2%B5lpme-for-the-determination-of-parabens-in-water-samples
#20
María Ramos-Payan, Santiago Maspoch, Andreu Llobera
A fast double-flow microfluidic based liquid phase microextraction (DF-µLPME) combined with a HPLC-UV procedure using diode array detection has been developed for the determination of the four most widely used parabens: Ethyl 4-hydroxybenzoate (EtP), Propyl 4-hydroxybenzoate (PrP), Butyl 4-hydroxybenzoate (BuP) and IsoButyl 4-hydroxybenzoate (iBuP) in water samples. Parabens have successfully been determined in environmental (lake and river water) samples with excellent clean up, high extraction efficiency and good enrichment factor using double-flow conditions...
April 1, 2017: Talanta
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