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Legionnaires disease

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https://www.readbyqxmd.com/read/28217110/intra-species-and-inter-kingdom-signaling-of-legionella-pneumophila
#1
REVIEW
Ramon Hochstrasser, Hubert Hilbi
The ubiquitous Gram-negative bacterium Legionella pneumophila parasitizes environ mental amoebae and, upon inhalation, replicates in alveolar macrophages, thus causing a life-threatening pneumonia called "Legionnaires' disease." The opportunistic pathogen employs a bi-phasic life cycle, alternating between a replicative, non-virulent phase and a stationary, transmissive/virulent phase. L. pneumophila employs the Lqs (Legionella quorum sensing) system as a major regulator of the growth phase switch. The Lqs system comprises the autoinducer synthase LqsA, the homologous sensor kinases LqsS and LqsT, as well as a prototypic response regulator termed LqsR...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28204479/antimicrobial-strategy-for-severe-community-acquired-legionnaires-disease-a-multicentre-retrospective-observational-study
#2
Jérôme Cecchini, Samuel Tuffet, Romain Sonneville, Muriel Fartoukh, Julien Mayaux, Damien Roux, Achille Kouatchet, Florence Boissier, Martial Tchir, Martial Thyrault, Eric Maury, Sebastien Jochmans, Armand Mekontso Dessap, Christian Brun-Buisson, Nicolas de Prost
No abstract text is available yet for this article.
February 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28203790/seeding-and-establishment-of-legionella-pneumophila-in-hospitals-implications-for-genomic-investigations-of-nosocomial-legionnaires-disease
#3
Sophia David, Baharak Afshar, Massimo Mentasti, Christophe Ginevra, Isabelle Podglajen, Simon R Harris, Victoria J Chalker, Sophie Jarraud, Timothy G Harrison, Julian Parkhill
No abstract text is available yet for this article.
February 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28203124/when-diarrhea-can-become-deadly-legionnaires-disease-complicated-by-bowel-obstruction
#4
Wesley Prichard, Laurel Fick
Legionnaires' disease may present with a broad spectrum of illnesses and nonspecific extrapulmonary symptoms including diarrhea. To our knowledge, bowel obstruction has not been reported as a manifestation of Legionella. We present a unique case of Legionnaires' disease contributing to a small bowel obstruction.
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28183814/comparative-proteomics-of-purified-pathogen-vacuoles-correlates-intracellular-replication-of-legionella-pneumophila-with-the-small-gtpase-rap1
#5
Johanna Schm Oumllders, Christian Manske, Andreas Otto, Christine Hoffmann, Bernhard Steiner, Amanda Welin, D Oumlrte Becher, Hubert Hilbi
Legionella pneumophila is an opportunistic bacterial pathogen that causes a severe lung infection termed Legionnaires disease. The pathogen replicates in environmental protozoa as well as in macrophages within a unique membrane-bound compartment, the Legionella-containing-vacuole (LCV). LCV formation requires the bacterial Icm/Dot type IV secretion system, which translocates ca. 300 effector proteins into host cells, where they target distinct host factors. The L. pneumophila pentuple mutant (Δpentuple) lacks 5 gene clusters (31% of the effector proteins) and replicates in macrophages but not in Dictyostelium discoideum amoeba...
February 9, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28159180/legionnaire-s-disease-and-its-protean-clinical-manifestations-the-ongoing-challenges-of-the-most-interesting-atypical-pneumonia
#6
EDITORIAL
Cheston B Cunha, Burke A Cunha
No abstract text is available yet for this article.
March 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/28159179/legionnaire-s-disease-and-its-mimics-a-clinical-perspective
#7
REVIEW
Burke A Cunha, Cheston B Cunha
Whenever the cardinal manifestations of a disorder occur in similar disorders, there is potential for a disease mimic. Legionnaire's disease has protean manifestations and has the potential to mimic or be mimicked by other community acquired pneumonias (CAPs). In CAPs caused by other than Legionella species, the more characteristic features in common with legionnaire's disease the more difficult the diagnostic conundrum. In hospitalized adults with CAP, legionnaire's disease may mimic influenza or other viral pneumonias...
March 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/28159178/legionnaire-s-disease-a-clinical-diagnostic-approach
#8
REVIEW
Burke A Cunha, Cheston B Cunha
Legionnaire's disease is a nonzoonotic atypical pneumonia caused by Legionella sp that occurs sporadically or in outbreaks. Legionnaire's disease pneumonia is accompanied by several extrapulmonary clinical and laboratory findings. Rather than testing all pneumonias for Legionnaire's disease, the clinical challenge is to recognize the diagnostic significance of Legionnaire's disease's. The pretest probability of Legionnaire's disease is increased if several characteristic extrapulmonary findings are present...
March 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/28159177/microbiology-and-epidemiology-of-legionnaire-s-disease
#9
REVIEW
Almudena Burillo, María Luisa Pedro-Botet, Emilio Bouza
Legionnaire's disease (LD) is the pneumonic form of legionellosis caused by aerobic gram-negative bacilli of the genus Legionella. Individuals become infected when they inhale aerosolized water droplets contaminated with Legionella species. Forty years after the identification of Legionella pneumophila as the cause of the 1976 pneumonia outbreak in a hotel in Philadelphia, we have non-culture-based diagnostic tests, effective antibiotics, and preventive measures to handle LD. With a mortality rate still around 10%, underreporting, and sporadic outbreaks, there is still much work to be done...
March 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/28159176/legionnaire-s-disease-cardiac-manifestations
#10
REVIEW
John L Brusch
Most cardiac infections with Legionella are secondary to bacteremias arising from a pulmonary focus. Other possible sites of origin are infected sternotomy wounds or equipment contaminated by Legionella spp. Legionella endocarditis is truly a "stealth" infection, with almost no hallmarks of bacterial endocarditis. The key step in making the diagnosis of Legionella endocarditis is for the physician to be aware of the clinical causes of culture-negative infective endocarditis and to include Legionella cardiac involvement in this differential...
March 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/28159175/thoracic-imaging-features-of-legionnaire-s-disease
#11
REVIEW
Sameer Mittal, Ayushi P Singh, Menachem Gold, Ann N Leung, Linda B Haramati, Douglas S Katz
Imaging examinations are often performed in patients with Legionnaires' disease. The literature to date has documented that the imaging findings in this disorder are relatively nonspecific, and it is therefore difficult to prospectively differentiate legionella pneumonia from other forms of pneumonia, and from other noninfectious thoracic processes. Through a review of clinical cases and the literature, our objective is for the reader to gain a better understanding of the spectrum of radiographic manifestations of Legionnaires' disease...
March 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/28159174/antimicrobial-therapy-for-legionnaire-s-disease-antibiotic-stewardship-implications
#12
REVIEW
Cheston B Cunha, Burke A Cunha
Legionnaire's disease is a common cause of community-acquired pneumonia (CAP). Although no single clinical feature is diagnostic, if characteristic extrapulmonary findings are present a presumptive clinical syndromic diagnosis is possible. Depending on geographic location, season, and physician awareness, Legionnaire's disease may be included in the differential diagnosis of CAP. Some antibiotics effective against Legionella sp are also effective in treating the typical bacterial causes of CAP. From an antimicrobial stewardship program (ASP) perspective, monotherapy is preferred to double-drug therapy...
March 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/28159173/legionnaire-s-disease-and-influenza
#13
REVIEW
Eleni E Magira, Sryros Zakynthinos
Legionella pneumophila and influenza types A and B viruses can cause either community-acquired pneumonia with respiratory failure, or Legionella infection could attribute to influenza infection with potentially fatal prognosis. Copathogenesis between pandemic influenza and bacteria is characterized by complex interactions between coinfecting pathogens and the host. Understanding the underlying reason of the emersion of the secondary bacterial infection during an influenza infection is challenging. The dual infection has an impact on viral control and may delay viral clearance...
March 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/28159172/legionnaire-s-disease-in-compromised-hosts
#14
REVIEW
Fanny Lanternier, Florence Ader, Benoit Pilmis, Emilie Catherinot, Sophie Jarraud, Olivier Lortholary
Legionnaire's disease (LD) is mainly reported in apparently immunocompetent patients. Among them, risk factors include chronic lung disease and smoking. However, LD is also well reported among immunocompromised patients, particularly those treated with anti-tumor necrosis factor alpha therapy, patients with hematological malignancy, and transplant patients. This article discusses the available data on immunity against Legionella spp, epidemiology, clinical presentation, diagnosis, and treatment of LD in immunocompromised patients...
March 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/28159171/severe-pneumonia-caused-by-legionella-pneumophila-differential-diagnosis-and-therapeutic-considerations
#15
REVIEW
Abdullah Chahin, Steven M Opal
Severe legionella pneumonia poses a diagnostic challenge and requires early intervention. Legionnaire's disease can have several presenting signs, symptoms, and laboratory abnormalities that suggest that Legionella pneumophila is the pathogen, but none of these are sufficient to distinguish L pneumophila pneumonia from other respiratory pathogens. L pneumophila is primarily an intracellular pathogen and needs treatment with antibiotics that efficiently enter the intracellular space.
March 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/28147210/regulating-cooling-towers-to-prevent-outbreaks-of-legionnaires-disease
#16
Mary T Bassett, Sharon Balter
No abstract text is available yet for this article.
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28141970/a-large-community-outbreak-of-legionnaires-disease-associated-with-a-cooling-tower-in-new-york-city-2015
#17
Don Weiss, Christopher Boyd, Jennifer L Rakeman, Sharon K Greene, Robert Fitzhenry, Trevor McProud, Kimberlee Musser, Li Huang, John Kornblum, Elizabeth J Nazarian, Annie D Fine, Sarah L Braunstein, Daniel Kass, Keren Landman, Pascal Lapierre, Scott Hughes, Anthony Tran, Jill Taylor, Deborah Baker, Lucretia Jones, Laura Kornstein, Boning Liu, Rodolfo Perez, David E Lucero, Eric Peterson, Isaac Benowitz, Kristen F Lee, Stephanie Ngai, Mitch Stripling, Jay K Varma
OBJECTIVES: Infections caused by Legionella are the leading cause of waterborne disease outbreaks in the United States. We investigated a large outbreak of Legionnaires' disease in New York City in summer 2015 to characterize patients, risk factors for mortality, and environmental exposures. METHODS: We defined cases as patients with pneumonia and laboratory evidence of Legionella infection from July 2 through August 3, 2015, and with a history of residing in or visiting 1 of several South Bronx neighborhoods of New York City...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28141673/implementation-of-a-legionella-ordinance-for-multifamily-housing-garland-texas
#18
Ellen A Whitney, Sarah Blake, Ruth L Berkelman
CONTEXT: The incidence of legionellosis has sharply increased in the United States as a result of contaminated water systems. Jurisdictions across the country are considering whether to develop and implement regulations to protect individuals against Legionnaires' disease with its associated high morbidity and mortality. OBJECTIVE: This article sheds light on the implementation and effectiveness of a 2005 citywide Legionella testing mandate of multifamily housing cooling towers in Garland, Texas...
January 30, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28129393/a-legionella-effector-disrupts-host-cytoskeletal-structure-by-cleaving-actin
#19
Yao Liu, Wenhan Zhu, Yunhao Tan, Ernesto S Nakayasu, Christopher J Staiger, Zhao-Qing Luo
Legionella pneumophila, the etiological agent of Legionnaires' disease, replicates intracellularly in protozoan and human hosts. Successful colonization and replication of this pathogen in host cells requires the Dot/Icm type IVB secretion system, which translocates approximately 300 effector proteins into the host cell to modulate various cellular processes. In this study, we identified RavK as a Dot/Icm substrate that targets the host cytoskeleton and reduces actin filament abundance in mammalian cells upon ectopic expression...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28123918/severe-legionella-pneumophila-infection-in-an-immunocompetent-patient-a-success-story-300-kilometers-away
#20
Miguel Jacob, Helena C Ramos, Bruno Morgado
The most significant outbreak of Legionella pneumophila, or Legionnaires' Disease, ever registered in Portugal occurred in 2014, and was considered one of the largest in European history. This relatively rare infection has a dire prognosis if not timely identified and correctly treated, presenting with a high lethality rate. We describe a case of infection by Legionella pneumophila in a previously healthy individual during an outbreak that originated 300 kilometers away from our hospital. The patient presented to the Emergency Department and after an initial assessment, was admitted to the Intensive Care Unit (ICU)...
December 21, 2016: Curēus
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