keyword
https://read.qxmd.com/read/38513403/-four-in-one-nanozyme-for-amplified-catalytic-photothermal-therapy
#21
JOURNAL ARTICLE
Qing Zhang, Tinglong Zhuang, Xiaohuan Sun, Yanli Bao, Liqi Zhu, Quan Zhang, Jie Han, Rong Guo
The cancer therapeutic efficacy of the peroxidase (POD)-mimicking nanozyme-based monotherapy is significantly hindered due to insufficient intratumoral hydrogen peroxide (H2 O2 ) and glutathione (GSH) consumption effect on reactive oxygen species (ROS). In this study, we present the development of poly(o-phenylenediamine)@gold nanoparticles (AuNPs) (PoPD@Au) nanocomposites for multifunctional catalytic-photothermal therapy. These nanocomposites exhibit triple distinct nanozymatic activities, i.e., POD-like activity that catalyzes H2 O2 to ROS, glucose oxidase (GOx)-like activity that supplements endogenous H2 O2 , and GSH depleting activity that decreases the ROS consumption efficiency...
March 19, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38513212/ternary-bioi-bi-2-s-3-au-nanosheet-arrays-as-a-photoelectrochemical-signal-converter-for-the-detection-of-cardiac-troponin-i
#22
JOURNAL ARTICLE
Weixuan Xu, Xuelin Zhang, Shanghua Liu, Feng Jiang, Yueyuan Li, Zhen Xu, Yueyun Li
Nanosheet arrays with stable signal output have become promising photoactive materials for photoelectrochemical (PEC) immunosensors. However, an essential concern is the facile recombination of carriers in one-component nanoarrays, which cannot be readily prevented, ultimately resulting in weak photocurrent signals. In this study, an immunosensor using gold nanoparticle-anchored BiOI/Bi2 S3 nanosheet arrays (BiOI/Bi2 S3 /Au) as a signal converter was fabricated for sensitive detection of cardiac troponin I (cTnI)...
March 21, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38513119/antigen-clustered-nanovaccine-achieves-long-term-tumor-remission-by-promoting-b-cd-4-t-cell-crosstalk
#23
JOURNAL ARTICLE
Chengyi Li, Ryan Clauson, Luke F Bugada, Fang Ke, Bing He, Zhixin Yu, Hongwei Chen, Binyamin Jacobovitz, Hongxiang Hu, Polina Chuikov, Brett Dallas Hill, Syed M Rizvi, Yudong Song, Kai Sun, Pasieka Axenov, Daniel Huynh, Xinyi Wang, Lana Garmire, Yu Leo Lei, Irina Grigorova, Fei Wen, Marilia Cascalho, Wei Gao, Duxin Sun
Current cancer vaccines using T cell epitopes activate antitumor T cell immunity through dendritic cell/macrophage-mediated antigen presentation, but they lack the ability to promote B/CD4 T cell crosstalk, limiting their anticancer efficacy. We developed antigen-clustered nanovaccine (ACNVax) to achieve long-term tumor remission by promoting B/CD4 T cell crosstalk. The topographic features of ACNVax were achieved using an iron nanoparticle core attached with an optimal number of gold nanoparticles, where the clusters of HER2 B/CD4 T cell epitopes were conjugated on the gold surface with an optimal intercluster distance of 5-10 nm...
March 21, 2024: ACS Nano
https://read.qxmd.com/read/38511189/rapid-hearing-threshold-assessment-with-modified-auditory-brainstem-response-protocols-in-dogs
#24
JOURNAL ARTICLE
Axel Stanger, Gesine Buhmann, Stefanie Dörfelt, Yury Zablotski, Andrea Fischer
INTRODUCTION: Auditory brainstem response (ABR) is the gold standard for hearing testing in dogs. ABR is commonly used in puppies to diagnose congenital sensorineural deafness. Long test times limit the use for a more comprehensive hearing screening in veterinary practice. This study aimed to establish a super-fast hearing screening protocol in dogs. METHODS: Hearing thresholds were routinely measured with a mobile device designed for newborn hearing screening in 90 dogs...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38509587/ultrasensitive-and-multiple-biomarker-discrimination-for-alzheimer-s-disease-via-plasmonic-microfluidic-sensing-technologies
#25
JOURNAL ARTICLE
Lijiao Zu, Xicheng Wang, Peng Liu, Jiwei Xie, Xuejun Zhang, Weiru Liu, Zhencheng Li, Shiqing Zhang, Kaiwei Li, Ambra Giannetti, Wei Bi, Francesco Chiavaioli, Lei Shi, Tuan Guo
As the population ages, the worldwide prevalence of Alzheimer's disease (AD) as the most common dementia in the elderly is increasing dramatically. However, a long-term challenge is to achieve rapid and accurate early diagnosis of AD by detecting hallmarks such as amyloid beta (Aβ42 ). Here, a multi-channel microfluidic-based plasmonic fiber-optic biosensing platform is established for simultaneous detection and differentiation of multiple AD biomarkers. The platform is based on a gold-coated, highly-tilted fiber Bragg grating (TFBG) and a custom-developed microfluidics...
March 20, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38509285/high-resolution-fluorescence-imaging-of-the-alveolar-scaffold-as-a-novel-tool-to-assess-lung-injury
#26
JOURNAL ARTICLE
Sandra Lindstedt, Qi Wang, Anna Niroomand, Martin Stenlo, Snejana Hyllen, Leif Pierre, Franziska Olm, Nicholas B Bechet
Acute lung injury (ALI) represents an aetiologically diverse form of pulmonary damage. Part of the assessment and diagnosis of ALI depends on skilled observer-based scoring of brightfield microscopy tissue sections. Although this readout is sufficient to determine gross alterations in tissue structure, its categorical scores lack the sensitivity to describe more subtle changes in lung morphology. To generate a more sensitive readout of alveolar perturbation we carried out high resolution immunofluorescence imaging on 200 μm lung vibratome sections from baseline and acutely injured porcine lung tissue, stained with a tomato lectin, Lycopersicon Esculentum Dylight-488...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38508722/optokinetic-nystagmus-six-practical-uses
#27
JOURNAL ARTICLE
David Edward Hale, Stephen Reich, Dan Gold
Optokinetic nystagmus (OKN) is a reflexive eye movement in response to movement of the viewer's visual environment that consists of a slow phase eye movement in the direction of the stimulus followed by a quick phase in the opposite direction. When tested at the bedside, the slow phases represent smooth pursuit, while the quick phases represent saccades. Normally, OKN is conjugate and symmetric (horizontally and vertically). Abnormalities in the optokinetic response can provide diagnostic and localising value...
March 20, 2024: Practical Neurology
https://read.qxmd.com/read/38508408/cannabidiol-and-it-fluorinate-analog-pecs-101-reduces-hyperalgesia-and-allodynia-in-trigeminal-neuralgia-via-trpv1-receptors
#28
JOURNAL ARTICLE
Daniela Maria Escobar-Espinal, Airam Nicole Vivanco-Estela, Núbia Barros, Maurício Dos Santos Pereira, Francisco Silveira Guimaraes, Elaine Del Bel, Glauce C Nascimento
Trigeminal neuralgia (TN) is an intense and debilitating orofacial pain. The gold standard treatment for TN is carbamazepine. This antiepileptic drug provides pain relief with limited efficacy and side effects. To study the antinociceptive potential of cannabidiol (CBD) and its fluorinated analog PECS-101 (former HUF-101), we induced unilateral chronic constriction injury of the infraorbital nerve (IoN-CCI) in male Wistar rats. Seven days of treatment with CBD (30 mg/kg), PECS-101 (3, 10, and 30 mg/kg), or carbamazepine (10 and 30 mg/kg) reduced allodynia and hyperalgesia responses...
March 19, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38508162/transthoracic-transdiaphragmatic-approach-in-laparoscopic-liver-resection-for-hepatocellular-carcinoma-in-a-patient-with-severe-obesity-and-history-of-deceased-donor-liver-transplantation
#29
JOURNAL ARTICLE
Akira Umemura, Hiroyuki Nitta, Daiki Takeda, Hirokatsu Katagiri, Shoji Kanno, Akira Sasaki
BACKGROUND: The transthoracic transdiaphragmatic approach (TTA) for hepatic tumors in laparoscopic liver resection (LLR) is not usually employed because the caudal approach via the abdominal cavity is the gold standard in LLRs. Here, we present a case of LLR via TTA for hepatocellular carcinoma (HCC) in a patient with severe obesity and a history of deceased donor liver transplantation (DDLT). MATERIALS AND SURGICAL TECHNIQUE: The patient, a 64-year-old man with severe obesity and a history of DDLT, was referred to our hospital to undergo LLR for HCC located at the cranial side of segment IV...
April 2024: Asian Journal of Endoscopic Surgery
https://read.qxmd.com/read/38507480/reactive-astrocytes-secrete-the-chaperone-hspb1-to-mediate-neuroprotection
#30
JOURNAL ARTICLE
Fangjia Yang, Paula Beltran-Lobo, Katherine Sung, Caoimhe Goldrick, Cara L Croft, Agnes Nishimura, Erin Hedges, Farah Mahiddine, Claire Troakes, Todd E Golde, Beatriz G Perez-Nievas, Diane P Hanger, Wendy Noble, Maria Jimenez-Sanchez
Molecular chaperones are protective in neurodegenerative diseases by preventing protein misfolding and aggregation, such as extracellular amyloid plaques and intracellular tau neurofibrillary tangles in Alzheimer's disease (AD). In addition, AD is characterized by an increase in astrocyte reactivity. The chaperone HSPB1 has been proposed as a marker for reactive astrocytes; however, its astrocytic functions in neurodegeneration remain to be elucidated. Here, we identify that HSPB1 is secreted from astrocytes to exert non-cell-autonomous protective functions...
March 22, 2024: Science Advances
https://read.qxmd.com/read/38506901/revealing-the-mysteries-of-population-mobility-amid-the-covid-19-pandemic-in-canada-comparative-analysis-with-internet-of-things-based-thermostat-data-and-google-mobility-insights
#31
JOURNAL ARTICLE
Kirti Sundar Sahu, Joel A Dubin, Shannon E Majowicz, Sam Liu, Plinio P Morita
BACKGROUND: The COVID-19 pandemic necessitated public health policies to limit human mobility and curb infection spread. Human mobility, which is often underestimated, plays a pivotal role in health outcomes, impacting both infectious and chronic diseases. Collecting precise mobility data is vital for understanding human behavior and informing public health strategies. Google's GPS-based location tracking, which is compiled in Google Mobility Reports, became the gold standard for monitoring outdoor mobility during the pandemic...
March 20, 2024: JMIR Public Health and Surveillance
https://read.qxmd.com/read/38505231/timing-and-location-of-speech-errors-induced-by-direct-cortical-stimulation
#32
JOURNAL ARTICLE
Heather Kabakoff, Leyao Yu, Daniel Friedman, Patricia Dugan, Werner K Doyle, Orrin Devinsky, Adeen Flinker
Cortical regions supporting speech production are commonly established using neuroimaging techniques in both research and clinical settings. However, for neurosurgical purposes, structural function is routinely mapped peri-operatively using direct electrocortical stimulation. While this method is the gold standard for identification of eloquent cortical regions to preserve in neurosurgical patients, there is lack of specificity of the actual underlying cognitive processes being interrupted. To address this, we propose mapping the temporal dynamics of speech arrest across peri-sylvian cortices by quantifying the latency between stimulation and speech deficits...
2024: Brain communications
https://read.qxmd.com/read/38504887/accelerating-haploid-induction-rate-and-haploid-validation-through-marker-assisted-selection-for-qhir1-and-qhir8-in-maize
#33
JOURNAL ARTICLE
Kanogporn Khammona, Abil Dermail, Khundej Suriharn, Thomas Lübberstedt, Samart Wanchana, Burin Thunnom, Wasin Poncheewin, Theerayut Toojinda, Vinitchan Ruanjaichon, Siwaret Arikit
Doubled haploid (DH) technology becomes more routinely applied in maize hybrid breeding. However, some issues in haploid induction and identification persist, requiring resolution to optimize DH production. Our objective was to implement simultaneous marker-assisted selection (MAS) for qhir1 ( MTL/ZmPLA1/NLD ) and qhir8 ( ZmDMP ) using TaqMan assay in F2 generation of four BHI306-derived tropical × temperate inducer families. We also aimed to assess their haploid induction rate (HIR) in the F3 generation as a phenotypic response to MAS...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38504031/bacterial-osteomyelitis-in-pediatric-patients-a-comprehensive-review
#34
REVIEW
Ricardo Restrepo, Halley J Park, S Pinar Karakas, Luisa F Cervantes, Felipe G Rodriguez-Ruiz, Anna Maria Zahrah, Emilio J Inarejos-Clemente, Marcelo Laufer, Verena M Shreiber
Bacterial osteomyelitis, an inflammatory response in the bone caused by microorganisms, typically affects the metaphysis in the skeletally immature. Bacterial osteomyelitis possesses a significant diagnostic challenge in pediatric patients due to its nonspecific clinical presentation. Because the metaphysis is the primary focus of infection in skeletally immature patients, understanding the normal physiologic, maturation process of bones throughout childhood allows to understand the pathophysiology of osteomyelitis...
March 20, 2024: Skeletal Radiology
https://read.qxmd.com/read/38503774/tacticai-an-ai-assistant-for-football-tactics
#35
JOURNAL ARTICLE
Zhe Wang, Petar Veličković, Daniel Hennes, Nenad Tomašev, Laurel Prince, Michael Kaisers, Yoram Bachrach, Romuald Elie, Li Kevin Wenliang, Federico Piccinini, William Spearman, Ian Graham, Jerome Connor, Yi Yang, Adrià Recasens, Mina Khan, Nathalie Beauguerlange, Pablo Sprechmann, Pol Moreno, Nicolas Heess, Michael Bowling, Demis Hassabis, Karl Tuyls
Identifying key patterns of tactics implemented by rival teams, and developing effective responses, lies at the heart of modern football. However, doing so algorithmically remains an open research challenge. To address this unmet need, we propose TacticAI, an AI football tactics assistant developed and evaluated in close collaboration with domain experts from Liverpool FC. We focus on analysing corner kicks, as they offer coaches the most direct opportunities for interventions and improvements. TacticAI incorporates both a predictive and a generative component, allowing the coaches to effectively sample and explore alternative player setups for each corner kick routine and to select those with the highest predicted likelihood of success...
March 19, 2024: Nature Communications
https://read.qxmd.com/read/38503119/synergistic-synthesis-of-gold-nanoflowers-as-upconversion-near-infrared-nanoprobe-energy-acceptor-and-recognition-unit-for-improved-hydrogen-sulfide-sensing
#36
JOURNAL ARTICLE
Hongyu Chen, Peipei Tian, Jiayi Guo, Manman Sun, Wenping Zhu, Zhendong Li, Zengchen Liu
A highly sensitive and selective upconversion near-infrared (NIR) fluorescence and colorimetric dual readout hydrogen sulfide (H2 S) nanoprobe was constructed based on the excellent NIR fluorescence emission performance of upconversion nanomaterials (UCNPs), the specific recognition effect of synergistically synthesized gold nanoflowers (trypsin-stabled AuNFs (Try-AuNFs)) and the effective NIR fluorescence quenching capability. In this assay, the sensing strategy included three processes. First of all, the synthesized UCNPs can emit 803 nm NIR fluorescence when they were excited by 980 nm excitation light...
March 15, 2024: Talanta
https://read.qxmd.com/read/38500611/highly-specific-colorimetric-detection-based-on-aggregation-of-l-cysteine-functionalized-gold-nanoparticles-for-cypermethrin-in-water-samples
#37
JOURNAL ARTICLE
Thitima Rujiralai, Nitchakarn Leelaharat, Wilairat Cheewasedtham
A fast, simple, and selective colorimetric assay for quantifying cypermethrin in water samples is proposed using l-cysteine functionalized gold nanoparticles (AuNPs@Cyst). Cypermethrin is hydrolyzed by potassium hydroxide to obtain hydrolyzed cypermethrin in the form of 3-phenoxybenzaldehyde by-product (HCy). The detection strategy is based on the aggregation of AuNPs@Cyst caused by hydrogen-bonding recognition between the aldehyde group of HCy and the amine group of l-cysteine on the surface of AuNPs@Cyst...
March 14, 2024: RSC Advances
https://read.qxmd.com/read/38499388/considering-the-response-in-addition-to-the-challenge-a-narrative-review-in-appraisal-of-a-motor-reserve-framework
#38
JOURNAL ARTICLE
Daniel Zeller, Shawn Hiew, Thorsten Odorfer, Carine Nguemeni
The remarkable increase in human life expectancy over the past century has been achieved at the expense of the risk of age-related impairment and disease. Neurodegeneration, be it part of normal aging or due to neurodegenerative disorders, is characterized by loss of specific neuronal populations, leading to increasing clinical impairment. The individual course may be described as balance between aging- or disease-related pathology and intrinsic mechanisms of adaptation. There is plenty of evidence that the human brain is provided with exhaustible resources to maintain function in the face of adverse conditions...
March 18, 2024: Aging
https://read.qxmd.com/read/38498835/ovarian-response-and-embryo-ploidy-following-oral-micronized-progesterone-primed-ovarian-stimulation-versus-gnrh-antagonist-protocol-a-prospective-study-with-repeated-ovarian-stimulation-cycles
#39
JOURNAL ARTICLE
M Del Mar Vidal, Francisca Martínez, Ignacio Rodríguez, Nikolaos P Polyzos
STUDY QUESTION: Is there any difference in ovarian response and embryo ploidy following progesterone-primed ovarian stimulation (PPOS) using micronized progesterone or GnRH antagonist protocol? SUMMARY ANSWER: Pituitary downregulation with micronized progesterone as PPOS results in higher number of oocytes retrieved and a comparable number of euploid blastocysts to a GnRH antagonist protocol. WHAT IS KNOWN ALREADY: Although the GnRH antagonist is considered by most the gold standard protocol for controlling the LH surge during ovarian stimulation (OS) for IVF/ICSI, PPOS protocols are being increasingly used in freeze-all protocols...
March 18, 2024: Human Reproduction
https://read.qxmd.com/read/38498568/from-primary-data-to-ethnopharmacological-investigations-on-achillea-erba-rotta-subsp-moschata-wulfen-i-richardson-as-a-remedy-against-gastric-ailments-in-valmalenco-italy
#40
JOURNAL ARTICLE
Martina Bottoni, Giulia Martinelli, Nicole Maranta, Emanuela Sabato, Fabrizia Milani, Lorenzo Colombo, Paola Sira Colombo, Stefano Piazza, Enrico Sangiovanni, Claudia Giuliani, Piero Bruschi, Giulio Vistoli, Mario Dell'Agli, Gelsomina Fico
(1) Background: Within the framework of the European Interreg Italy-Switzerland B-ICE & Heritage project (2018-2022), this study originated from a three-year ethnobotanical survey in Valmalenco (Sondrio, Italy). Following a preliminary work published by our group, this research further explored the folk therapeutic use of Achillea erba-rotta subsp. moschata (Wulfen) I.Richardson (Asteraceae) for dyspepsia disorders, specifically its anti-inflammatory potential at a gastrointestinal level. (2) Methods: Semi-structured interviews were performed...
February 16, 2024: Plants (Basel, Switzerland)
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