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https://www.readbyqxmd.com/read/29334277/validation-of-dpoae-screening-conducted-by-village-health-workers-in-a-rural-community-with-real-time-click-evoked-tele-auditory-brainstem-response
#1
Vidya Ramkumar, C S Vanaja, James W Hall, K Selvakumar, Roopa Nagarajan
OBJECTIVE: This study assessed the validity of DPOAE screening conducted by village health workers (VHWs) in a rural community. Real-time click evoked tele-auditory brainstem response (tele-ABR) was used as the gold standard to establish validity. DESIGN: A cross-sectional design was utilised to compare the results of screening by VHWs to those obtained via tele-ABR. Study samples: One hundred and nineteen subjects (0 to 5 years) were selected randomly from a sample of 2880 infants and young children who received DPOAE screening by VHWs...
January 15, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29334076/pt-decorated-mos-sub-2-sub-nanoflakes-for-ultrasensitive-resistive-humidity-sensor
#2
Debasree Burman, Sumita Santra, Panchanan Pramanik, Prasanta Kumar Guha
In this work, we report the fabrication of a low power, humidity sensor where platinum nanoparticles (NPs) decorated few-layered Molybdenum disulphide (MoS<sub>2</sub>) nanoflakes have been used as the sensing layer. A mixed solvent was used to exfoliate the nanoflakes from the bulk powder. Then the Pt/MoS<sub>2</sub> composites were prepared by reducing Pt NPs from chloroplatinic acid hexahydrate using a novel reduction technique using sulfide salt. The successful reduction and composite preparation were confirmed using various material characterization tools like Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM), X-Ray Diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), Raman spectroscopy and UV-visible spectroscopy (UV-Vis)...
January 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29332794/a-sensitive-spr-biosensor-based-on-hollow-gold-nanospheres-and-improved-sandwich-assay-with-pda-ag-fe3o4-rgo
#3
Shuo Li, Qiong Wu, Pinyi Ma, Yue Zhang, Daqian Song, Xinghua Wang, Ying Sun
A novel surface plasmon resonance (SPR) biosensor based on hollow gold nanospheres (HGNPs) and an improved sandwich assay was developed to detect rabbit IgG. The electromagnetic coupling between the HGNPs and Au film, and the notable plasmonic fields spread over the inner and outer surfaces of HGNPs, led to the considerable amplification of the SPR signal. Polydopamine-Ag@Fe3O4/reduced graphene oxide (PDA-Ag@Fe3O4/rGO) was introduced to bind detection antibody (Ab2) to form the improved sandwich structure. Ag nanoparticles were excited to produce SPR and their hot electrons were doped on graphene thin films, which amplified the response of biomolecules...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29331449/quantifying-axonal-responses-in-patient-specific-models-of-subthalamic-deep-brain-stimulation
#4
Kabilar Gunalan, Bryan Howell, Cameron C McIntyre
Medical imaging has played a major role in defining the general anatomical targets for deep brain stimulation (DBS) therapies. However, specifics on the underlying brain circuitry that is directly modulated by DBS electric fields remain relatively undefined. Detailed biophysical modeling of DBS provides an approach to quantify the theoretical responses to stimulation at the cellular level, and has established a key role for axonal activation in the therapeutic mechanisms of DBS. Estimates of DBS-induced axonal activation can then be coupled with advances in defining the structural connectome of the human brain to provide insight into the modulated brain circuitry and possible correlations with clinical outcomes...
January 10, 2018: NeuroImage
https://www.readbyqxmd.com/read/29327943/phenotyping-pharyngeal-pathophysiology-using-polysomnography-in-patients-with-obstructive-sleep-apnea
#5
Scott A Sands, Bradley A Edwards, Philip I Terrill, Luigi Taranto-Montemurro, Ali Azarbarzin, Melania Marques, Lauren Hess, David P White, Andrew Wellman
RATIONALE: Therapies for obstructive sleep apnea (OSA) could be administered based on a patient's own phenotypic causes ("traits") if a clinically-applicable approach were available. Here we present a novel approach to quantify two key contributors to OSA-pharyngeal collapsibility and compensatory muscle responsiveness-that is applicable to diagnostic polysomnography. METHODS: Based on physiological definitions, pharyngeal collapsibility determines the ventilation at normal (eupneic) ventilatory drive during sleep, and pharyngeal compensation determines the rise in ventilation accompanying a rising ventilatory drive...
January 12, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29327429/in-vivo-migration-of-endogenous-brain-progenitor-cells-guided-by-an-injectable-peptide-amphiphile-biomaterial
#6
Reza Motalleb, Eric J Berns, Piyush Patel, Julie Gold, Samuel I Stupp, H Georg Kuhn
Biomaterials hold great promise in helping the adult brain regenerate and rebuild after trauma. Peptide amphiphiles (PA) are highly versatile biomaterials, gelling and forming macromolecular structures when exposed to physiological levels of electrolytes. We are here reporting on the first ever in vivo use of self-assembling peptide amphiphile carrying a Tenascin-C signal (E2 Ten-C PA) for the re-direction of endogenous neuroblasts in the rodent brain. The PA forms highly aligned nanofibers, displaying the migratory sequence of Tenascin-C glycoprotein as epitope...
January 12, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29326816/immune-checkpoint-inhibition-prospects-for-prevention-and-therapy-of-hepatocellular-carcinoma
#7
REVIEW
Caryn L Elsegood, Janina Ee Tirnitz-Parker, John K Olynyk, George Ct Yeoh
The global prevalence of liver cancer is rapidly rising, mostly as a result of the amplified incidence rates of viral hepatitis, alcohol abuse and obesity in recent decades. Treatment options for liver cancer are remarkably limited with sorafenib being the gold standard for advanced, unresectable hepatocellular carcinoma but offering extremely limited improvement of survival time. The immune system is now recognised as a key regulator of cancer development through its ability to protect against infection and chronic inflammation, which promote cancer development, and eliminate tumour cells when present...
November 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29324913/the-detection-of-endocarditis-post-implantation-grafts-arteritis-and-other-related-disorders-by-18f-fdg-pet-ct
#8
Jelena Šaponjski, Dragana Šobić-Šaranović, Strahinja Odalović, Milica Stojiljković, Jelena Pantović, Nebojša Petrović, Isidora Grozdić-Milojević, Vera Artiko
INTRODUCTION: Positron emission tomography with computed tomography (18F-FDG PET/CT) is a nuclear medicine diagnostic method which, unlike other technological modalities that asses anatomical features, detects increased glucose metabolism inside the cells, thus is very helpful in diagnosing cardiovascular infection and inflammation and also in therapy planning. AIM: Aim of this study was to assess the significance of 18F-FDG PET/CT in detection of an active disease in patients with infection and inflammation of cardiovascular system...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324858/mapping-the-geographical-distribution-of-podoconiosis-in-cameroon-using-parasitological-serological-and-clinical-evidence-to-exclude-other-causes-of-lymphedema
#9
Kebede Deribe, Amuam Andrew Beng, Jorge Cano, Abdel Jelil Njouendo, Jerome Fru-Cho, Abong Raphael Awah, Mathias Esum Eyong, Patrick W Chounna Ndongmo, Emanuele Giorgi, David M Pigott, Nick Golding, Rachel L Pullan, Abdisalan M Noor, Fikre Enquselassie, Christopher J L Murray, Simon J Brooker, Simon I Hay, Peter Enyong, Melanie J Newport, Samuel Wanji, Gail Davey
BACKGROUND: Podoconiosis is a non-filarial elephantiasis, which causes massive swelling of the lower legs. It was identified as a neglected tropical disease by WHO in 2011. Understanding of the geographical distribution of the disease is incomplete. As part of a global mapping of podoconiosis, this study was conducted in Cameroon to map the distribution of the disease. This mapping work will help to generate data on the geographical distribution of podoconiosis in Cameroon and contribute to the global atlas of podoconiosis...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29324685/novel-spectroscopic-and-electrochemical-sensors-and-nanoprobes-for-the-characterization-of-food-and-biological-antioxidants
#10
REVIEW
Reşat Apak, Sema Demirci Çekiç, Ayşem Üzer, Saliha Esin Çelik, Mustafa Bener, Burcu Bekdeşer, Ziya Can, Şener Sağlam, Ayşe Nur Önem, Erol Erçağ
Since an unbalanced excess of reactive oxygen/nitrogen species (ROS/RNS) causes various diseases, determination of antioxidants that can counter oxidative stress is important in food and biological analyses. Optical/electrochemical nanosensors have attracted attention in antioxidant activity (AOA) assessment because of their increased sensitivity and selectivity. Optical sensors offer advantages such as low cost, flexibility, remote control, speed, miniaturization and on-site/in situ analysis. Electrochemical sensors using noble metal nanoparticles on modified electrodes better catalyze bioelectrochemical reactions...
January 11, 2018: Sensors
https://www.readbyqxmd.com/read/29324648/lspr-and-interferometric-sensor-modalities-combined-using-a-double-clad-optical-fiber
#11
Harald Ian Muri, Andon Bano, Dag Roar Hjelme
We report on characterization of an optical fiber-based multi-parameter sensor concept combining localized surface plasmon resonance (LSPR) signal and interferometric sensing using a double-clad optical fiber. The sensor consists of a micro-Fabry-Perot in the form of a hemispherical stimuli-responsive hydrogel with immobilized gold nanorods on the facet of a cleaved double-clad optical fiber. The swelling degree of the hydrogel is measured interferometrically using the single-mode inner core, while the LSPR signal is measured using the multi-mode inner cladding...
January 11, 2018: Sensors
https://www.readbyqxmd.com/read/29324295/analytical-determination-of-the-reducing-and-stabilization-agents-present-in-different-zostera-noltii-extracts-used-for-the-biosynthesis-of-gold-nanoparticles
#12
Rafael Zarzuela, Manuel Jesús Luna, María Luisa Almoraima Gil, María Jesús Ortega, José María Palacios-Santander, Ignacio Naranjo-Rodríguez, Juan José Delgado, Laura María Cubillana-Aguilera
The objective of this work was to ascertain the nature of the components responsible for the reducing and stabilizing properties of Zostera noltii extracts that lead to gold nanoparticle formation using chemical techniques of analysis. In order to achieve this aim, we try the synthesis of AuNPs with three different extracts from plants collected in the Bay of Cádiz (Spain). The n-butanol extract produced the best results. Taking this into account, four fractions were isolated by Sephadex LH-20 column chromatography from this extract and we studied their activity...
December 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29323915/resonance-energy-transfer-promoted-photothermal-and-photodynamic-performance-of-gold-copper-sulfide-yolk-shell-nanoparticles-for-chemophototherapy-of-cancer
#13
Yun Chang, Yan Cheng, Yanlin Feng, Hui Jian, Li Wang, Xiaomin Ma, Xi Li, Haiyuan Zhang
Gold (Au) core@void@copper sulfide (CuS) shell (Au-CuS) yolk-shell nanoparticles (YSNPs) were prepared in the present study for potential chemo-, photothermal, and photodynamic combination therapy, so called "chemophototherapy". The resonance energy transfer (RET) process was utilized in Au-CuS YSNPs to achieve both enhanced photothermal and photodynamic performance compared with those of CuS hollow nanoparticles (HNPs). A series of Au nanomaterials as cores that had different localized surface plasmon resonance (LSPR) absorption peaks at 520, 700, 808, 860, and 980 nm were embedded in CuS HNPs to screen the most effective Au-CuS YSNPs according to the RET process...
January 11, 2018: Nano Letters
https://www.readbyqxmd.com/read/29323714/a-new-gold-standard-approach-to-characterize-the-transport-of-si-across-cell-membranes-in-animals
#14
Alexandre P Garneau, Andrée-Anne Marcoux, Rachelle Frenette-Cotton, Richard Bélanger, Paul Isenring
Silicon (Si) is increasingly recognized as an essential trace element in animals, especially since the identification of mammalian Si transport systems and Si responsive genes. During many years, however, efforts to gain substantial insight into the biological role of this element in animals have achieved partial success due in part to the unavailability of validated protocols to study Si movement across biological membranes. To circumvent such limitations, we have developed a general transport assay in which cellular Si content was determined by automated electrothermal atomic absorption spectrophotometry...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29323249/probabilistic-data-integration-identifies-reliable-gametocyte-specific-proteins-and-transcripts-in-malaria-parasites
#15
Lisette Meerstein-Kessel, Robin van der Lee, Will Stone, Kjerstin Lanke, David A Baker, Pietro Alano, Francesco Silvestrini, Chris J Janse, Shahid M Khan, Marga van de Vegte-Bolmer, Wouter Graumans, Rianne Siebelink-Stoter, Taco W A Kooij, Matthias Marti, Chris Drakeley, Joseph J Campo, Teunis J P van Dam, Robert Sauerwein, Teun Bousema, Martijn A Huynen
Plasmodium gametocytes are the sexual forms of the malaria parasite essential for transmission to mosquitoes. To better understand how gametocytes differ from asexual blood-stage parasites, we performed a systematic analysis of available 'omics data for P. falciparum and other Plasmodium species. 18 transcriptomic and proteomic data sets were evaluated for the presence of curated "gold standards" of 41 gametocyte-specific versus 46 non-gametocyte genes and integrated using Bayesian probabilities, resulting in gametocyte-specificity scores for all P...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321075/a-phase-i-open-label-trial-on-the-safety-and-immunogenicity-of-the-adjuvanted-tuberculosis-subunit-vaccine-h1-ic31%C3%A2-in-people-living-in-a-tb-endemic-area
#16
Jemal Hussein, Martha Zewdie, Lawrence Yamuah, Ahmed Bedru, Markos Abebe, Alemnew F Dagnew, Menberework Chanyalew, Asfawesen G Yohannes, Jemal Ahmed, Howard Engers, T Mark Doherty, Peter Bang, Ingrid Kromann, Søren T Hoff, Abraham Aseffa
BACKGROUND: H1/IC31® is a tuberculosis (TB) subunit vaccine candidate consisting of the fusion protein of Ag85B and ESAT-6 (H1) formulated with the IC31® adjuvant. Previous trials have reported on the H1/IC31® vaccine in M. tuberculosis (Mtb)-naïve, BCG-vaccinated and previously Mtb-infected individuals. In this trial, conducted between December 2008 and April 2010, the safety and immunogenicity of H1/IC31® was assessed in participants living in Ethiopia - a highly TB-endemic area...
January 10, 2018: Trials
https://www.readbyqxmd.com/read/29318378/mac-2-binding-protein-glycan-isomer-m2bpgi-is-a-new-serum-biomarker-for-assessing-liver-fibrosis-more-than-a-biomarker-of-liver-fibrosis
#17
REVIEW
Ken Shirabe, Yuki Bekki, Dolgormaa Gantumur, Kenichiro Araki, Norihiro Ishii, Atsushi Kuno, Hisashi Narimatsu, Masashi Mizokami
Assessing liver fibrosis is important for predicting the efficacy of antiviral therapy and patient prognosis. Liver biopsy is the gold standard for diagnosing liver fibrosis, despite its invasiveness and problematic diagnostic accuracy. Although noninvasive techniques to assess liver fibrosis are becoming important, reliable serum surrogate markers are not available. A glycoproteomics study aimed at identifying such markers discovered Mac 2-Binding Protein Gylcan Isomer (M2BPGi), which is a reliable marker for assessing liver fibrosis in patients with viral hepatitis and other fibrotic liver diseases such as primary biliary cholangitis, biliary atresia, autoimmune hepatitis, and nonalcoholic fatty liver disease...
January 9, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29317434/investigating-low-velocity-fluid-flow-in-tumors-using-convection-mri
#18
Simon Walker-Samuel, Thomas A Roberts, Rajiv Ramasawmy, Jake S Burrell, Sean P Johnson, Bernard M Siow, Simon Richardson, Miguel R Goncalves, Douglas Pendse, Simon P Robinson, R Barbara Pedley, Mark F Lythgoe
Several distinct fluid flow phenomena occur in solid tumors, including intravascular blood flow and interstitial convection. Interstitial fluid pressure is often raised in solid tumors, which can limit drug delivery. To probe low-velocity flow in tumors resulting from raised interstitial fluid pressure, we developed a novel magnetic resonance imaging (MRI) technique named convection-MRI, which uses a phase-contrast acquisition with a dual-inversion vascular nulling preparation to separate intra- and extra-vascular flow...
January 9, 2018: Cancer Research
https://www.readbyqxmd.com/read/29316389/naphthalocyanine-as-a-new-photothermal-actuator-for-lipid-based-drug-delivery-systems
#19
Joanne D Du, Linda Hong, Angel Tan, Ben J Boyd
One approach to address the substantial global burden of ocular diseases such as aged related macular degeneration is using light-activated drug delivery to obviate the need for highly invasive and frequent need for costly intravitreal injections. To enable such systems, new light responsive materials are required. This communication reports the use of silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) (SiNC), a small molecule photosensitizer as a new actuator for triggering light responsive lipid-based drug delivery systems...
January 9, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29316016/non-invasive-measurement-of-reepithelialization-and-microvascularity-of-suction-blister-wounds-with-benchmarking-to-histology
#20
Heidi Fhaer Larsen, Malin Glindvad Ahlström, Lise Mette Rahbek Gjerdrum, Mette Mogensen, Khaled Ghathian, Henrik Calum, Anne Lyngholm Sørensen, Julie Lyng Forman, Mark Vandeven, Marian N Holerca, Laurence Du-Thumm, Lars Nannestad Jorgensen, Magnus S Ågren
We explored use of the suction-blister wound model in the assessment of not only epidermal regeneration but also pain, the microvascular response and bacteriology. The effects of topical zinc sulfate were studied to articulate the methodologies in this double-blind trial. One epidermal suction blister (10 mm) was induced on each buttock in 30 healthy volunteers (15 females:15 males) and de-roofed on day 0. The wounds were randomized to daily treatment with 1.4% zinc sulfate shower gel (n = 20), placebo (n = 20) or control (n = 20)...
January 8, 2018: Wound Repair and Regeneration
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