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https://www.readbyqxmd.com/read/28240862/engineering-of-surface-chemistry-for-enhanced-sensitivity-in-nanoporous-interferometric-sensing-platforms
#1
Cheryl Suwen Law, Georgina Sylvia, Mahdieh Nemati, Jingxian Yu, Dusan Losic, Andrew D Abell, Abel Santos
In this study, we explore new approaches to engineering the surface chemistry of interferometric sensing platforms based on nanoporous anodic alumina (NAA) and reflectometric interference spectroscopy (RIfS). Two surface engineering strategies are presented, namely; (i) selective chemical functionalization of the inner surface of NAA pores with amine-terminated thiol molecules, and (ii) selective chemical functionalization of the top surface of NAA with dithiol molecules. The strong molecular interaction of Au3+ ions with thiol-containing functional molecules of alkane chain or peptide character provides a model sensing system with which to assess the sensitivity of these NAA platforms by both molecular feature and surface engineering...
February 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28239426/validation-of-non-smoking-status-by-spouse-following-a-cessation-intervention
#2
Raul M Mejia, Sandra Braun, Lorena Peña, Steven E Gregorich, Eliseo J Pérez-Stable
BACKGROUND: Following cessation interventions, self-reported smoking abstinence with biochemical verification is the "gold standard" for defining outcomes. Because obtaining biochemical verification is challenging in community studies, we compared self-reported cessation among smokers completing treatment to the smoking status reported by each participant's spouse or proxy. METHOD: Participants were smokers who had reported quitting 12 months after a cessation intervention...
March 2017: Journal of Smoking Cessation
https://www.readbyqxmd.com/read/28238752/gold-nanoparticle-interactions-in-human-blood-a-model-evaluation
#3
Niloofar Ajdari, Cian Vyas, Stephanie L Bogan, Bashir A Lwaleed, Brian G Cousins
In this study, we investigated gold nanoparticle (AuNP) interactions in blood using thromboelastography as a rapid screening tool to monitor their influence on blood coagulation. 1.2nM colloidal AuNPs ranging from 12 to 85nm have no effect in the blood, however, 5nM AuNPs demonstrate pro-thrombogenic concentration dependent effects with a reduction in clot formation. Size effects exhibit a non-linear trend with 45 and 85nm particles resulting in a faster pro-thrombotic response. Clot strength decreased with AuNP size with the greatest reduction with 28nm particles...
February 23, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28238138/dual-wavelength-triggered-gold-nanorods-for-anticancer-treatment
#4
Dennis B Pacardo, Frances S Ligler, Zhen Gu
Gold nanomaterials with light-responsive properties can be exploited as light-triggered delivery vehicles to enhance the therapeutic efficacy of anticancer drugs. Additionally, different wavelengths of light can be utilized to achieve the combined effects of light-triggered release of therapeutics and light-induced localized heating, which results in improved anticancer efficacy. Herein, we describe methods to develop gold nanorod (AuNR) complexes that provide drug delivery or photothermal therapy when activated by ultraviolet (UV) or near-infrared (NIR) wavelengths of light, respectively...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28238108/enhanced-vascular-biocompatibility-of-decellularized-xeno-allogeneic-matrices-in-a-rodent-model
#5
M van Steenberghe, T Schubert, Y Guiot, C Bouzin, X Bollen, P Gianello
Glutaraldehyde preservation is the gold standard for cardiovascular biological prosthesis. However, secondary calcifications and the absence of tissue growth remain major limitations. Our study assessed in vitro and in vivo the biocompatibility of human (fascia lata, pericardium) and porcine tissues (pericardium, peritoneum) treated with a physicochemical procedure for decellularization and non-conventional pathogens inactivation. Biopsies were performed before and after treatment to assess decellularization (HE/Dapi staining/DNA quantification/MHC I/alpha gal immunostaining) and mechanical integrity...
February 25, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28238028/prepotent-response-inhibition-and-reaction-times-in-children-with-attention-deficit-hyperactivity-disorder-from-a-caribbean-community
#6
Giomar Jiménez-Figueroa, Carlos Ardila-Duarte, David A Pineda, Johan E Acosta-López, Martha L Cervantes-Henríquez, Wilmar Pineda-Alhucema, Jeimys Cervantes-Gutiérrez, Marisol Quintero-Ibarra, Manuel Sánchez-Rojas, Jorge I Vélez, Pedro J Puentes-Rozo
Impairment in inhibitory control has been postulated as an underlying hallmark of attention deficit/hyperactivity disorder (ADHD), which can be utilized as a quantitative trait for genetic studies. Here, we evaluate whether inhibitory control, measured by simple automatized prepotent response (PR) inhibition variables, is a robust discriminant function for the diagnosis of ADHD in children and can be used as an endophenotype for future genetic studies. One hundred fifty-two school children (30.9% female, 67...
February 25, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/28237754/one-pot-electrochemical-synthesis-of-poly-melamine-entrapped-gold-nanoparticles-composite-for-sensitive-and-low-level-detection-of-catechol
#7
Selvakumar Palanisamy, Sayee Kannan Ramaraj, Shen-Ming Chen, Te-Wei Chiu, Vijayalakshmi Velusamy, Thomas C K Yang, Tse-Wei Chen, Sonadevi Selvam
A simple and cost effective synthesis of nanomaterials with advanced physical and chemical properties have received much attention to the researchers, and is of interest to the researchers from different disciplines. In the present work, we report a simple and one pot electrochemical synthesis of poly(melamine) entrapped gold nanoparticles (PM-AuNPs) composite. The PM-AuNPs composite was prepared by a single step electrochemical method, wherein the AuNPs and PM were simultaneously fabricated on the electrode surface...
December 29, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28236223/calcipotriol-plus-betamethasone-dipropionate-aerosol-foam-in-patients-with-moderate-to-severe-psoriasis-sub-group-analysis-of-the-pso-able-study
#8
Carle Paul, Craig Leonardi, Alan Menter, Kristian Reich, Linda Stein Gold, Richard B Warren, Anders Møller, Mark Lebwohl
BACKGROUND: Fixed-combination calcipotriol 50 μg/g plus betamethasone 0.5 mg/g (Cal/BD) aerosol foam is a new topical treatment for psoriasis. Although moderate-to-severe psoriasis is typically treated with systemic/biologic therapies, a topical treatment that is efficacious in these patients may be a significant cost-saving alternative to systemic therapy. OBJECTIVE: The objective of this study was to assess the response to Cal/BD foam and gel in patients with moderate-to-severe psoriasis enrolled in the phase III, 12-week PSO-ABLE study...
February 24, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28235556/relation-of-polymorphism-of-arsenic-metabolism-genes-to-arsenic-methylation-capacity-and-developmental-delay-in-preschool-children-in-taiwan
#9
Ru-Lan Hsieh, Chien-Tien Su, Horng-Sheng Shiue, Wei-Jen Chen, Shiau-Rung Huang, Ying-Chin Lin, Ming-I Lin, Shu-Chi Mu, Ray-Jade Chen, Yu-Mei Hsueh
Inefficient arsenic methylation capacity has been associated with developmental delay in children. The present study was designed to explore whether polymorphisms and haplotypes of arsenic methyltransferase (AS3MT), glutathione-S-transferase omegas (GSTOs), and purine nucleoside phosphorylase (PNP) affect arsenic methylation capacity and developmental delay. A case-control study was conducted from August 2010 to March 2014. All participants were recruited from the Shin Kong Wu Ho-Su Memorial Teaching Hospital...
February 21, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28231589/ultrasound-elastography-in-diffuse-and-focal-parotid-gland-lesions
#10
Naglaa Mansour, Benedikt Hofauer, Andreas Knopf
In Europe, ultrasound (US) is the diagnostic gold standard for the visualisation of parotid gland disorders. While high-resolution B-mode US reliably visualises focal lesions, its diagnostic capacity to distinguish tumour entities or to characterise diffuse lesions remains poor. Strain elastography (SE) and shear wave elastography (SWE) are novel imaging techniques that provide additional information about tissue elasticity. SE analyses the strain or displacement in response to force or compression and, therefore, shows the relative tissue elasticity within a selected region of interest (ROI)...
2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28230925/not-all-athletes-are-equal-but-don-t-call-me-an-exerciser-response-to-araujo-and-scharhag-2016
#11
Clare MacMahon, Lucy Parrington
Many Olympians and Paralympians would not be called athletes if what dictates this classification is fulfilling the criteria of Araujo and Scharhag (2016). Shelley Watts, Australian amateur boxer and Commonwealth gold medallist undertakes a double degree in law and sports science, something which undoubtedly takes up a considerable number of hours throughout her week (Australian Olympic Committie [AOC], 2016). There are many other athletes in similar positions - College athletes in the United States who are part of the National Collegiate Athletic Association (NCAA), for example...
February 23, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28229535/enrichment-and-viability-inhibition-of-circulating-tumor-cells-on-a-dual-acid-responsive-composite-nanofiber-film
#12
Wenqian Wang, Yaya Cheng, Yansheng Li, Hao Zhou, Li-Ping Xu, Yongqiang Wen, Liang Zhao, Xueji Zhang
The formation and metastatic colonization of circulating tumor cells (CTCs) are responsible for the vast majority of cancer-related deaths. Over the last decade, drug delivery system (DDS) has been rapidly developed with nanotechnology arising, however, most of the reported tumor-targeting DDSs were just able to deliver drugs to the solid tumor cells but not CTCs. In here, a novel drug delivery system was constructed with composite nanofiber film to inhibit the viability of circulating tumor cells (CTCs). In this system, gold nanoparticles (Au NPs) were functionalized with doxorubicin (DOX) through an acid-responsive cleavable linker to get the Au-DOX NPs...
February 23, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28229114/the-trier-social-stress-test-principles-and-practice
#13
REVIEW
Andrew P Allen, Paul J Kennedy, Samantha Dockray, John F Cryan, Timothy G Dinan, Gerard Clarke
Researchers interested in the neurobiology of the acute stress response in humans require a valid and reliable acute stressor that can be used under experimental conditions. The Trier Social Stress Test (TSST) provides such a testing platform. It induces stress by requiring participants to make an interview-style presentation, followed by a surprise mental arithmetic test, in front of an interview panel who do not provide feedback or encouragement. In this review, we outline the methodology of the TSST, and discuss key findings under conditions of health and stress-related disorder...
February 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28228226/-progress-of-pd-1-pd-l1-inhibitors-in-non-small-cell-lung-cancer
#14
Zhansheng Jiang, Zhanyu Pan, Xiubao Ren
Pembrolizumab, an inhibitor target programmed death 1 (PD-1), was approved into the first line therapy in advanced non-small cell lung cancer (NSCLC). It was a milestone that immune checkpoints drugs have played an important role in the treatment system of NSCLC. The results of clinical trials revealed the superiority of PD-1/programmed death ligand 1 (PD-L1) inhibitors compared with chemotherapy in first-line, second-line and multidrug resistance phase therapy. Objective response rate (ORR) was up to 80% with pembrolizumab plus chemotherapy, and progression-free survival (PFS) with single pembrolizumab in first line was nearly 1 year (10...
February 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28225874/experimental-burns-comparison-between-silver-sulfadiazine-and-photobiomodulation
#15
Mariana Teixeira Gomes, Gabriela Russo Soeiro Campos, Natália Piccolo, Cristiane Miranda França, Guelton Hirano Guedes, Fabio Lopes, Renata A Belotto, Christiane Pavani, Rafael do Nascimento de Lima, Daniela de Fátima Teixeira da Silva
OBJECTIVE: To analyze morphological characteristics and organization of the collagen fibers of third degree burns from scalding compared to laser therapy and silver sulfadiazine, the latter considered as the gold standard. METHOD: Were selected 12 animals (Rattus norvegicus) also divided into three groups (control group [CG] - untreated burns; sulfadiazine group [SG] - burns were treated with silver sulfadiazine at 1%; laser group [LG] - burns were treated with photobiomodulation)...
January 1, 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28225624/optical-observation-of-plasmonic-nonlocal-effects-in-a-2d-superlattice-of-ultrasmall-gold-nanoparticles
#16
Hao Shen, Li Chen, Lorenzo Ferrari, Meng-Hsien Lin, N Asger Mortensen, Shangjr Gwo, Zhaowei Liu
The advances in recent nanofabrication techniques have facilitated explorations of metal structures into nanometer scales, where the traditional local-response Drude model with hard-wall boundary conditions fails to accurately describe their optical responses. The emerging nonlocal effects in single ultrasmall silver nanoparticles have been experimentally observed in single-particle spectroscopy enabled by the unprecedented high spatial resolution of electron energy loss spectroscopy (EELS). However, unambiguous optical observation of such new effects in gold nanoparticles has yet not been reported, due to the extremely weak scattering and the obscuring fingerprint of strong interband transitions...
February 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/28225477/mechanical-efficiency-in-chronic-obstructive-pulmonary-disease
#17
Willem Gosens, Alex J Vanʼt Hul, Joost M Oomen, Matthijs K C Hesselink, Lars B Borghouts
PURPOSE: The primary aims of this study were (1) to evaluate whole-body mechanical efficiency (ME) in a large group of chronic obstructive pulmonary disease (COPD) patients with a wide range of degrees of illness and (2) to examine how ME in COPD is related to absolute work rate and indices of disease severity during exercise testing. METHODS: A total of 569 patients (301 male patients; GOLD stage I: 28, GOLD stage II: 166, GOLD stage III: 265, and GOLD stage IV: 110) with chronic obstructive pulmonary disease (COPD) were included in the data analysis...
March 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28225338/potential-biomarkers-associated-with-discrimination-between-latent-and-active-pulmonary-tuberculosis
#18
R Kamakia, S Kiazyk, J Waruk, A Meyers, J Ochanda, T B Ball, J Oyugi
SETTING: A third of the world's population has latent tuberculous infection (LTBI). Current TB diagnostics used in developing countries are ineffective and are unable to distinguish LTBI from active TB. Identifying biomarkers that could aid in the early detection of TB and in distinguishing TB states could be a major breakthrough in global TB control. OBJECTIVE: To identify potential immune biomarkers to distinguish active TB from LTBI. DESIGN: A cross-sectional study was conducted among 19 active TB patients, 8 TB-negative individuals (controls) and 16 LTBI non-human immunodeficiency virus infected individuals in Nairobi, Kenya...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28222220/meaningful-endpoints-for-therapies-approved-for-hematologic-malignancies
#19
B Douglas Smith, Amy E DeZern, Alex W Bastian, Brian G M Durie
BACKGROUND: Overall survival (OS) is considered the gold standard for determining treatment efficacy in oncology trials, but the relation between treatment and OS can be challenging to assess because of long study durations and the impact of subsequent therapies on outcome. Using OS can be particularly difficult for new therapies in hematologic malignancies (HMs). METHODS: This retrospective analysis was conducted to characterize the primary endpoints used to support US Food and Drug Administration (FDA) approvals for new drug or novel HM indications between January 2002 and July 2015...
February 21, 2017: Cancer
https://www.readbyqxmd.com/read/28222187/a-purified-maa-based-elisa-is-a-useful-tool-for-determining-anti-maa-antibody-titer-with-high-sensitivity
#20
Takasumi Shimomoto, Leonard B Collins, Xianwen Yi, Darcy W Holley, Zhenfa Zhang, Xu Tian, Koji Uchida, Chunguang Wang, Sohvi Hörkkö, Monte S Willis, Avram Gold, Scott J Bultman, Jun Nakamura
Atherosclerosis is widely accepted to be a chronic inflammatory disease, and the immunological response to the accumulation of LDL is believed to play a critical role in the development of this disease. 1,4-Dihydropyridine-type MAA-adducted LDL has been implicated in atherosclerosis. Here, we have demonstrated that pure MAA-modified residues can be chemically conjugated to large proteins without by-product contamination. Using this pure antigen, we established a purified MAA-ELISA, with which a marked increase in anti-MAA antibody titer was determined at a very early stage of atherosclerosis in 3-month ApoE-/- mice fed with a normal diet...
2017: PloS One
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