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https://www.readbyqxmd.com/read/29791450/significant-acceleration-of-emergency-response-using-smartphone-geolocation-data-and-a-worldwide-emergency-call-support-system
#1
Michael Weinlich, Peter Kurz, Melissa B Blau, Felix Walcher, Stefan Piatek
IMPORTANCE: When patients are disorientated or experience language barriers, it is impossible to activate the emergency response system. In these cases, the delay for receiving appropriate help can extend to several hours. OBJECTIVES: A worldwide emergency call support system (ECSS), including geolocation of modern smartphones (GPS, WLAN and LBS), was established referring to E911 and eCall systems. The system was tested for relevance in quickly forwarding abroad emergency calls to emergency medical services (EMS)...
2018: PloS One
https://www.readbyqxmd.com/read/29788323/development-and-psychometric-properties-of-the-inflammatory-bowel-disease-distress-scale-ibd-ds-a-new-tool-to-measure-disease-specific-distress
#2
Lesley Dibley, Wladyslawa Czuber-Dochan, Sue Woodward, Tiffany Wade, Paul Bassett, Jackie Sturt, Christine Norton
Background: Inflammatory bowel disease (IBD) imposes a heavy psychosocial burden, with many patients reporting anxiety, depression, and distress. In diseases such as diabetes, disease-specific distress is associated with concordance with treatments and disease control. IBD distress, distinct from anxiety and depression, is evident in people with IBD. We aimed to develop a questionnaire for assessing IBD-specific distress, validate this against a gold standard distress measure for diabetes, and demonstrate the difference between anxiety, depression, and distress...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29787713/interferon-gamma-release-assay-performance-in-northeastern-brazil-influence-of-the-ifng-874-a-t-polymorphism
#3
Valdirene Leão Carneiro, Maria Teresita Bendicho, Rosalina Guedes Santos, Marilda Casela, Eduardo M Netto, Scarlet Torres Moraes Mota, Iza Cristina Araújo Pina, Roberto Meyer Nascimento, Songeli Menezes Freire, Theolis Barbosa
INTRODUCTION: Latent tuberculosis infection diagnosis based on the release of interferon-gamma in cultures of peripheral blood cells stimulated with Mycobacterium tuberculosis antigens has replaced the tuberculin skin test in many countries with low tuberculosis prevalence. The IFN-γ production can be influenced by genetic polymorphisms, of which the IFNG+874 (rs62559044) locus is the most studied. We investigated the possible influence of the IFNG+874 A/T polymorphism on interferon-gamma test performance...
May 19, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29787561/interplay-of-strain-and-race-ethnicity-in-the-innate-immune-response-to-m-tuberculosis
#4
P Nahid, L G Jarlsberg, M Kato-Maeda, M R Segal, D H Osmond, S Gagneux, K Dobos, M Gold, P C Hopewell, D M Lewinsohn
BACKGROUND: The roles of host and pathogen factors in determining innate immune responses to M. tuberculosis are not fully understood. In this study, we examined host macrophage immune responses of 3 race/ethnic groups to 3 genetically and geographically diverse M. tuberculosis lineages. METHODS: Monocyte-derived macrophages from healthy Filipinos, Chinese and non-Hispanic White study participants (approximately 45 individuals/group) were challenged with M. tuberculosis whole cell lysates of clinical strains Beijing HN878 (lineage 2), Manila T31 (lineage 1), CDC1551 (lineage 4), the reference strain H37Rv (lineage 4), as well as with Toll-like receptor 2 agonist lipoteichoic acid (TLR2/LTA) and TLR4 agonist lipopolysaccharide (TLR4/LPS)...
2018: PloS One
https://www.readbyqxmd.com/read/29786742/a-novel-alendronate-functionalized-nanoprobe-for-simple-colorimetric-detection-of-cancer-associated-hypercalcemia
#5
Abhishek Sahu, Youngmin Hwang, Cristian Vilos, Jong-Min Lim, Sunghyun Kim, Won Il Choi, Giyoong Tae
The calcium (Ca2+) ion concentration in the blood serum is tightly regulated, and any abnormalities in the level of serum calcium ions are associated with many potentially dangerous diseases. Thus, monitoring of the Ca2+ ion concentration in the blood serum is of fundamental importance. Gold nanoparticle (GNP)-based colorimetric biosensors have enormous potential in clinical diagnostic applications due to their simplicity, versatility, and unique optical properties. In this study, we have developed an alendronate functionalized gold nanoparticle (GNP-ALD) system for the measurement of Ca2+ ion concentration in biological samples...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29786706/hg-ii-interactions-with-t-rich-regions-in-oligonucleotides-effects-of-positional-variations-on-the-electrochemical-properties
#6
Ajar Kamal, Renu Sharma, Zhe She, Heinz-Bernhard Kraatz
Hg(ii) binding to thymine-rich oligonucleotides (ODNs) is investigated electrochemically. The focus of this study is to probe the effects of position on the electrochemical response. For this purpose, three oligonucleotides were investigated in which the position of a hexa-thymine repeat is varied within a surface-supported oligonucleotide. The hexa repeats were placed in the top, middle, and bottom positions within the strand with respect to the gold surface. The effects were monitored by electrochemical impedance spectroscopy and scanning electrochemical microscopy...
May 22, 2018: Analyst
https://www.readbyqxmd.com/read/29786508/-use-of-the-evalobs-%C3%A2-adherence-scale-in-an-unselected-french-population-of-treated-subjects-with-antihypertensive-hypolipemiants-or-oral-antidiabetics-medications-the-flahs-2017-adherence-survey
#7
X Girerd, O Hanon, B Vaïsse
OBJECTIVE: A Visual Analog Scale (VAS) is useful for diagnosing medication nonadherence and its validity has been evaluated using electronic pillbox as the gold standard. We have developed the EvaLobs® scale for use on paper or on smartphone and the aim of the study was to administrate the scale among FLAHS 2017 participants treated for an hypertension, a dyslipidemia or diabetes. In subjects treated with antihypertensive medications, participants completed the 6-item Girerd Scale and EvaLobs® ...
May 18, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29783082/multiplexed-aptasensor-based-on-metal-ions-labels-for-simultaneous-detection-of-multiple-antibiotic-residues-in-milk
#8
Falan Li, Yemin Guo, Xiangyou Wang, Xia Sun
A dual-target electrochemical aptasensor was developed for the simultaneous detection of multiple antibiotics based on metal ions as signal tracers and nanocomposites as signal amplification strategy. Metal ions such as Cd2+ and Pb2+ could generate distinct differential pulse voltammetry (DPV) peaks. When targets were present, kanamycin (KAN) and streptomycin (STR) as models, the KAN aptamer (KAP) and STR aptamer (STP) were released from their complementary strands, with more change of Cd2+ and Pb2+ corresponding to peak currents...
April 13, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29783026/a-prolonged-and-large-outbreak-of-invasive-group-a-streptococcal-disease-within-a-nursing-home-repeated-intra-facility-transmission-of-a-single-strain
#9
S A Nanduri, B J Metcalf, M A Arwady, C Edens, M A Lavin, J Morgan, W Clegg, A Beron, J P Albertson, R Link-Gelles, A Ogundimu, J Gold, D Jackson, S Chochua, N Stone, C Van Beneden, K Fleming-Dutra, B Beall
OBJECTIVES: Multiple invasive group A streptococcal (GAS) infections were reported to public health by a skilled nursing facility (Facility A) in Illinois between May 2014 and August 2016. Cases continued despite interventions including antibiotic prophylaxis for all residents and staff. Two other geographically close facilities reported contemporaneous outbreaks of GAS. We investigated potential reasons for ongoing transmission. METHODS: We obtained epidemiologic data from chart review of cases and review of facility and public health records from previous investigations into the outbreak...
May 18, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29782542/validation-of-the-refugee-health-screener-15-for-the-assessment-of-perinatal-depression-among-karen-and-burmese-women-on-the-thai-myanmar-border
#10
Gracia Fellmeth, Emma Plugge, Mina Fazel, Prakaykaew Charunwattana, François Nosten, Raymond Fitzpatrick, Julie A Simpson, Rose McGready
Perinatal depression is common, and left untreated can have significant and long-lasting consequences for women, their children and their families. Migrant women are at particular risk of perinatal depression as a result of a multitude of stressors experienced before, during and after migration. Identification of perinatal depression among migrant women-particularly those living in low- and middle-income regions-remains challenging, partly due to the lack of locally-validated and culturally appropriate screens tools...
2018: PloS One
https://www.readbyqxmd.com/read/29782306/urticarial-lesions-in-a-pregnant-woman
#11
Sergio Santos-Alarcón, Cesar Benavente-Villegas, Isabel García-Briz, Magdalena Moneva-Léniz, Celia Sanchis-Sánchez, Almudena Mateu-Puchades
Dear Editor, Gestational pemphigoid (GP) is a rare autoimmune bullous dermatosis in pregnancy. GP usually occurs during the second or third month of pregnancy. It clinically manifests as the development of either early-onset urticarial lesions or late-onset subepidermal blisters that may linger for weeks or even months. Herein we report the case of a 45-year-old woman with the distinctive clinical onset of GP. A forty-five-year-old woman, gravida I, para 0, at 27 weeks gestation, was referred for evaluation to our Department with an extensive pruritic eruption that had developed over the previous 7 days...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782172/assembly-dynamics-of-plasmonic-dna-capped-gold-nanoparticle-monolayers
#12
Thomas L Derrien, Michelle Zhang, Patrick Dorion, Detlef-M Smilgies, Dan Luo
The self-assembly of nanoparticles in aqueous solutions promises wide applications but requires the careful balance of many parameters not present in organic solvents. While the presence of long-range electrostatic interactions in aqueous solutions may complicate such assemblies, they provide additional parameters through which to control self-assembly. Here, with DNA-capped gold nanoparticles and through variation of the ionic strength in aqueous solutions, we explored the influence of electrostatic interactions on the adsorption of negatively charged nanoparticles on a positively charged surface...
May 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29781445/enhanced-room-temperature-gas-sensing-of-aligned-mn3o4-nanorods-assemblies-functionalized-by-aluminum-anodic-membranes
#13
Neetha Rachel John, Paulose Thomas, Divya K V, Abraham K E
The study signifies a conductometric chemical sensor design using aligned Mn3O4 nanorods. Nanostructuring is an emerging field of prominence due to its capacity to introduce unprecedented properties in materials with potential applications. Hydrothermally prepared in situ Mn3O4 sample appears in urchin rod like morphology which changes to spherical shape on annealing. An aluminum anodic membrane/template (AAO) is used for the growth of the nanorods and also as a medium to support the sensor. Aligned Mn3O4nanorods are formed in the pores of AAO by vacuum infiltration approach which is later on annealed...
May 21, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29778960/rapid-colorimetric-detection-of-p53-protein-function-using-dna-gold-nanoconjugates-with-applications-for-drug-discovery-and-cancer-diagnostics
#14
Enock Assah, Walter Goh, Xin Ting Zheng, Ting Xiang Lim, Jun Li, David Lane, Farid Ghadessy, Yen Nee Tan
The tumor suppressor protein p53 plays a central role in preventing cancer through interaction with DNA response elements (REs) to regulate target gene expression in cells. Due to its significance in cancer biology, relentless efforts have been directed toward understanding p53-DNA interactions for the development of cancer therapeutics and diagnostics. In this paper, we report a rapid, label-free and versatile colorimetric assay to detect wildtype p53 DNA-binding function in complex solutions. The assay design is based on a concept that alters interparticle-distances between RE-AuNPs from a crosslinking effect induced through tetramerization of wildtype p53 protein (p53-WT) upon binding to canonical DNA motifs modified on gold nanoparticles (RE-AuNPs)...
May 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29778160/food-contamination-as-a-pathway-for-lead-exposure-in-children-during-the-2010-2013-lead-poisoning-epidemic-in-zamfara-nigeria
#15
Simba Tirima, Casey Bartrem, Ian von Lindern, Margrit von Braun, Douglas Lind, Shehu Mohamed Anka, Aishat Abdullahi
In 2010, an estimated 400 to 500 children died of acute lead poisoning associated with artisanal gold mining in Zamfara, Nigeria. Processing of gold ores containing up to 10% lead within residential compounds put residents, especially children, at the highest risk. Principal routes of exposure were incidental ingestion and inhalation of contaminated soil and dusts. Several Nigerian and international health organizations collaborated to reduce lead exposures through environmental remediation and medical treatment...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29777313/gold-nanocluster-based-ratiometric-fluorescent-probes-for-hydrogen-peroxide-and-enzymatic-sensing-of-uric-acid
#16
Dongqin Yang, Minchuan Luo, Junwei Di, Yifeng Tu, Jilin Yan
A method is described for ratiometric fluorometric assays of H2 O2  by using two probes that have distinct response profiles. Under the catalytic action of ferrous ion, the 615 nm emission of protein-stabilized gold nanoclusters (under 365 nm photoexcitation) is quenched by H2 O2 , while an increased signal is generated with a peak at 450 nm by oxidizing coumarin with the H2 O2 /Fe(II) system to form a blue emitting fluorophore. These decrease/increase responses give a ratiometric signal. The ratio of the fluorescences at the two peaks are linearly related to the concentration of H2 O2 in the range from 0...
May 18, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29777119/changes-in-t-cell-effector-functions-over-an-8-year-period-with-tnf-antagonists-in-patients-with-chronic-inflammatory-rheumatic-diseases
#17
Ilaria Sauzullo, Rossana Scrivo, Paola Sessa, Fabio Mengoni, Vincenzo Vullo, Guido Valesini, Claudio Maria Mastroianni
The aim of the study was to clarify the effect of long-term anti-TNF therapy on T cell function in patients with rheumatologic immune-mediated inflammatory diseases (IMID). The production of IFNγ by T cells was evaluated at baseline and after 1, 2, 4, and 8 years of anti-TNF agents by means of a QuantiFERON-TB Gold In-Tube assay. The T cell proliferation and surface co-expression of CD25/CD134 in response to phytohaemagglutinin together with the in vitro impact of anti-TNF therapy on the functional capacity of T cells were evaluated after 8 years from the onset of the biological treatment...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29776542/aggregation-of-cysteamine-capped-gold-nanoparticles-in-presence-of-atp-as-an-analytical-tool-for-rapid-detection-of-creatine-kinase-ck-mm
#18
Amit Kumar Sharma, Sunil Pandey, Yowan Nerthigan, Nandini Swaminathan, Hui-Fen Wu
Creatine kinase, a key biomarker associated with many debilitating physiological conditions has seldom been detected in biological fluids using functionalized gold nanoparticles (GNPs). We have developed a method based on the aggregation of cysteamine (Cys) functionalized GNPs in presence of ATP for effective detection of creatine kinase (CK-MM). Positively charged Cys-GNPs (brick red color) aggregate in presence of negatively charged ATP (blue color) but the process is prevented when CK-MM is added to the solution...
September 18, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29776482/does-pain-intensity-matter-the-relation-between-coping-and-quality-of-life-in-pediatric-patients-with-chronic-pain
#19
Alexis K Yetwin, Nicole E Mahrer, Cindy John, Jeffrey I Gold
PURPOSE: Chronic pain is a complex and debilitating chronic health condition that negatively impacts a child's daily function. Previous investigations of coping behaviors in youth with chronic illness have suggested that secondary control/accommodative coping may be more adaptive than primary control/active coping or disengagement/passive coping. However, studies have not considered how pain intensity may change the effect of various coping strategies on functioning in this pediatric population...
May 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29775856/a-simple-ultrasensitive-electrochemical-sensor-for-simultaneous-determination-of-gallic-acid-and-uric-acid-in-human-urine-and-fruit-juices-based-on-zirconia-choline-chloride-gold-nanoparticles-modified-carbon-paste-electrode
#20
Seyed Alireza Shahamirifard, Mehrorang Ghaedi, Zahra Razmi, Shaaker Hajati
The determination of gallic acid (GA) and uric acid (UA) is essential due to their biological properties. Numerous methods have been reported for the analysis of GA and UA in various real samples. However, the development of a simple, rapid and practical sensor still remains a great challenge. Here, a carbon paste electrode (CPE) was modified by nanocomposite containing zirconia nanoparticles (ZrO2 NPs), Choline chloride (ChCl) and gold nanoparticles (AuNPs) to construct ZrO2 -ChCl-AuNPs/CPE as electrochemical sensor for the simultaneous electro-oxidation of GA and UA...
May 8, 2018: Biosensors & Bioelectronics
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