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https://www.readbyqxmd.com/read/29145259/impulse-oscillometry-system-as-an-alternative-diagnostic-method-for-chronic-obstructive-pulmonary-disease
#1
Xia Wei, Zhihong Shi, Yajuan Cui, Jiuyun Mi, Zhengquan Ma, Jingting Ren, Jie Li, Shudi Xu, Youmin Guo
We aimed to compare impulse oscillation system (IOS) and traditional pulmonary function tests (PFTs) for the assessment of the severity of chronic obstructive pulmonary disease (COPD), and to assess the use of IOS parameters to identify patients who were forced expiratory volume in 1 second (FEV1)%pred < 50%.Patients with COPD (n = 215) were enrolled at the Ninth Hospital of Xi'an Affiliated Hospital of Xi'an Jiaotong University between October 2014 and September 2016. All patients were assessed by traditional PFT and IOS...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144124/ionic-liquid-microstrips-impregnated-with-magnetic-nano-stirrers-for-sensitive-gas-sensors
#2
Richard Gondosiswanto, David Brynn Hibbert, Yu Fang, Chuan Zhao
Ionic liquids have been regarded as promising electrolytes as substitutes for volatile aqueous or organic solvents for electrochemical gas sensors. However ionic liquids are viscous and the slow diffusion of gas molecules leads to poor sensitivity and sluggish response times. Herein, we describe a strategy using an array of microstrips of ionic liquid containing magnetic nanoparticles as nano-stirrers for enhanced mass transport and gas sensing. Magnetic CoFe2O4 nanoparticles are synthesized and dispersed in a hydrophobic ionic liquid [BMP][Ntf2]...
November 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29143766/assessment-of-micronutrient-status-in-critically-ill-children-challenges-and-opportunities
#3
REVIEW
Duy T Dao, Lorenzo Anez-Bustillos, Bennet S Cho, Zhilling Li, Mark Puder, Kathleen M Gura
Micronutrients refer to a group of organic vitamins and inorganic trace elements that serve many functions in metabolism. Assessment of micronutrient status in critically ill children is challenging due to many complicating factors, such as evolving metabolic demands, immature organ function, and varying methods of feeding that affect nutritional dietary intake. Determination of micronutrient status, especially in children, usually relies on a combination of biomarkers, with only a few having been established as a gold standard...
October 28, 2017: Nutrients
https://www.readbyqxmd.com/read/29142046/quantitative-analysis-of-interferon-%C3%AE-release-assay-response-in-children-with-latent-and-active-tuberculosis
#4
Giulia Lombardi, Roberta Petrucci, Ilaria Corsini, Maria Letizia Bacchi Reggiani, Francesca Visciotti, Filippo Bernardi, Maria Paola Landini, Salvatore Cazzato, Paola Dal Monte
The use of interferon-γ (IFN-γ) release assays (IGRAs) for the diagnosis of tuberculosis (TB) infection in children is still under debate because of concerns about their immature immune response.The aim of this study was to investigate quantitative values of QuantiFERON®-TB Gold In-Tube (QFT-IT), a commercially available IGRA, in a large cohort of children screened for TB infection.A retrospective analysis was conducted on samples from 517 children aged 0-14 years old at the Pediatric Unit of S. Orsola-Malpighi University Hospital of Bologna (Italy); quantitative responses to QFT-IT stimuli were analyzed according to diagnosis and age...
November 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29141973/energy-metabolism-profile-in-individuals-with-prader-willi-syndrome-and-implications-for-clinical-management-a-systematic-review
#5
REVIEW
Maha Alsaif, Sarah A Elliot, Michelle L MacKenzie, Carla M Prado, Catherine J Field, Andrea M Haqq
Prader-Willi syndrome (PWS) is a rare genetic disorder associated with excessive weight gain. Hyperphagia associated with PWS may result in higher energy intake, but alterations in energy expenditure may also contribute to energy imbalance. The purpose of this critical literature review is to determine the presence of alterations in energy expenditure in individuals with PWS. Ten studies that measured total energy expenditure (TEE), resting energy expenditure (REE), sleep energy expenditure (SEE), activity energy expenditure (AEE), and diet induced thermogenesis (DIT) were included in this review...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29141062/management-of-severe-acne-vulgaris-with-topical-therapy
#6
Linda Stein Gold, Hilary E Baldwin, Tina Lin
<p>Acne vulgaris (acne) is the most common skin disease we see in dermatology practice. Although rare in childhood, severe acne can affect up to 12% of the adolescent population. A chronic disease, it requires both aggressive management and effective maintenance strategies. Oral antibiotics, in combination with topical agents are recommended for treatment, with topical agents being continued as maintenance therapy to minimize resistance and recurrence. However, concerns with systemic side effects have recently resulted in a greater focus on the potential of fixed combination topical therapies to treat severe acne...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29140684/janus-gold-nanoplatform-for-synergetic-chemoradiotherapy-and-computed-tomography-imaging-of-hepatocellular-carcinoma
#7
Zheng Wang, Dan Shao, Zhimin Chang, Mengmeng Lu, Yingshuai Wang, Juan Yue, Dian Yang, Mingqiang Li, Qiaobing Xu, Wenfei Dong
There is a pressing need to develop nanoplatforms that integrate multimodal therapeutics to improve treatment responses and prolong the survival of patients with unresectable hepatocellular carcinoma (HCC). Mesoporous silica-coated gold nanomaterials have emerged as a novel multifunctional platform combining tunable surface plasmon resonance and mesoporous properties that exhibit multimodality properties in cancer theranostics. However, their reduced radiation-absorption efficiency and limited surface area hinder their further radiochemotherapeutic applications...
November 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/29137881/comparison-between-chloral-hydrate-and-propofol-ketamine-as-sedation-regimens-for-pediatric-auditory-brainstem-response-testing
#8
Kamal Abulebda, Vinit J Patel, Sheikh S Ahmed, Alvaro J Tori, Riad Lutfi, Samer Abu-Sultaneh
INTRODUCTION: The use of diagnostic auditory brainstem response testing under sedation is currently the "gold standard" in infants and young children who are not developmentally capable of completing the test. OBJECTIVE: The aim of the study is to compare a propofol-ketamine regimen to an oral chloral hydrate regimen for sedating children undergoing auditory brainstem response testing. METHODS: Patients between 4 months and 6 years who required sedation for auditory brainstem response testing were included in this retrospective study...
October 28, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29137753/synthesis-of-nanocomposites-of-iron-oxide-gold-fe3o4-au-loaded-on-activated-carbon-and-their-application-in-water-treatment-by-using-sonochemistry-optimization-study
#9
Saideh Bagheri, Hossein Aghaei, Mehrorang Ghaedi, Arash Asfaram, Majid Monajemi, Ali Akbar Bazrafshan
This paper focuses on the finding best operational conditions using response surface methodology (RSM) for Rhodamine123 (R123) and Disulfine blue (DSB) dyes removal by ultrasound assisted adsorption onto Au-Fe3O4 nanoparticles loaded on activated carbon (Au-Fe3O4 NPs-AC). The influences of variables such as initial R123 (X1) and DSB concentration (X2), pH (X3), adsorbent mass (X4) and sonication time (X5) on their removal were investigated by small central composite design (CCD) under response surface methodology...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137703/fabrication-of-a-novel-aptasensor-based-on-three-dimensional-reduced-graphene-oxide-polyaniline-gold-nanoparticle-composite-as-a-novel-platform-for-high-sensitive-and-specific-cocaine-detection
#10
Pegah Hashemi, Hasan Bagheri, Abbas Afkhami, Yalda Hosseinzadeh Ardakani, Tayyebeh Madrakian
In the present research, we have developed a novel label free aptasensor based on screen printed carbon electrode (SPCE) modified with three-dimensional magnetic reduced graphene oxide(3D-MRGO)/polyaniline(PA)/gold nanoparticle(AuNP) nanocomposite for impedimetric determination of cocaine. To achieve this goal, a specific thiolated cocaine aptamer was immobilized onto the surface of synthesized nanocomposite. The signaling mechanism of the proposed aptasensor was based on increase in the [Fe(CN)6](3-/4-) charge transfer resistance (RCT) as an electrochemical probe in the presence of target analyte...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29136358/is-secretion-of-ifn-gamma-in-response-to-mycobacterium-tuberculosis-antigens-in-youngest-children-sufficient-to-play-a-role-in-tb-diagnostics
#11
Teresa Bielecka, Anna Komorowska-Piotrowska, Katarzyna Krenke, Wojciech Feleszko, Marek Kulus
OBJECTIVES: To assess whether children ≤5 years of age, produce sufficient amounts of interferon gamma (IFN-ɣ) in response to phytohaemagglutinin (mitogen), and Mycobacterium tuberculosis antigens (TB antigens) in the QuantiFERON-TB Gold in-Tube test (QFT-GIT), (Cellestis Ltd., Australia). WORKING HYPOTHESIS: Is TB-antigen-induced IFN-ɣ response in children ≤5 years sufficient to consider QFT-GIT a possible tool for TB diagnostics? Study design, patient-subject selection, and methods: We recruited children 0-17 years old suspected of TB infection to this cross-sectional study, in whom QFT-GIT and TST were performed...
November 14, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29136344/the-hypoxic-test-in-preterm-neonates-reinvestigated
#12
Christelle Kouakam, Erwan Stephan-Blanchard, André Léké, Guy Kongolo, Elodie Haraux, Stéphane Delanaud, Frédéric Telliez, Karen Chardon
AIM: We currently lack a suitable gold-standard method for implementation on modern equipment to assess peripheral chemoreceptor sensitivity. The aim of the present study was to develop an accurate and reproducible method for assessing peripheral chemoreceptors sensitivity in sleeping preterm neonates. METHODS: A poïkilocapnic hypoxic test was performed twice during rapid eye movement sleep (REM sleep) and non-rapid eye movement sleep (nonREM sleep). The infant breathed hypoxic gas (15% O2 ) for 60 s...
November 14, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29136197/mapping-vis-terahertz-%C3%A2-17-thz-surface-plasmons-sustained-on-native-and-chemically-functionalized-percolated-gold-thin-films-using-eels
#13
Patricia Abellan, Patrick Z El-Khoury, Quentin M Ramasse
Heterogeneous assemblies of molecules (Rhodamine B) adsorbed onto a nano-corrugated metallic surface (a percolated Au network) are investigated using electron energy loss spectroscopy in the scanning transmission electron microscope (STEM-EELS). Our first measurements target the native metallic substrate, which consists of a commercial Au thin film atop an ultrathin carbon membrane. The Au film displays a percolated morphology with nanostructures of estimated thickness ≤10 nm approximately. We observe a rich plasmonic response from the metallic substrate; one which varies nanometrically and spans the VIS-terahertz region...
November 9, 2017: Microscopy
https://www.readbyqxmd.com/read/29135944/design-synthesis-and-use-of-peptides-derived-from-human-papillomavirus-l1-protein-for-the-modification-of-gold-electrode-surfaces-by-self-assembled-monolayers
#14
John Alejandro Lara Carrillo, Ricardo Fierro Medina, Juan Manríquez Rocha, Erika Bustos Bustos, Diego Sebastián Insuasty Cepeda, Javier Eduardo García Castañeda, Zuly Jenny Rivera Monroy
In order to obtain gold electrode surfaces modified with Human Papillomavirus L1 protein (HPV L1)-derived peptides, two sequences, SPINNTKPHEAR and YIK, were chosen. Both have been recognized by means of sera from patients infected with HPV. The molecules, Fc-Ahx-SPINNTKPHEAR, Ac-C-Ahx-(Fc)KSPINNTKPHEAR, Ac-C-Ahx-SPINNTKPHEAR(Fc)K, C-Ahx-SPINNTKPHEAR, and (YIK)₂-Ahx-C, were designed, synthesized, and characterized. Our results suggest that peptides derived from the SPINNTKPHEAR sequence, containing ferrocene and cysteine residues, are not stable and not adequate for electrode surface modification...
November 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29135514/prevalence-and-clinical-characteristics-of-local-allergic-rhinitis-to-house-dust-mites
#15
Yoo Seob Shin, Chang-Gyu Jung, Hae-Sim Park
PURPOSE OF REVIEW: Local allergic rhinitis (LAR) is a recently classified subtype of rhinitis defined by a nasal allergic response in patients without systemic evidence of atopy. Recent studies have reported the prevalence, clinical course, culprit allergens, diagnostic methods and treatment outcomes of LAR. The purpose of this review is to summarize the most relevant and updated scientific evidence for LAR, especially focusing on its prevalence and clinical characteristics. RECENT FINDINGS: LAR is found in a significant proportion (3...
November 14, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29135001/nanomaterials-for-the-optical-detection-of-fluoride
#16
REVIEW
Yongming Guo, Jing Li, Shuming Chai, Jingjing Yao
Overexposure to fluoride ions (F(-)) causes serious diseases in human beings. Extensive efforts have been made to develop sensitive and selective approaches for F(-) detection and a variety of F(-) sensors have been constructed recently. The burgeoning nanotechnology has provided novel materials for F(-) analysis due to the extraordinary properties of nanomaterials. In this review, we present the recent advances in different nanomaterials-based approaches for the optical F(-) detection via colorimetric, fluorescent and chemiluminescent responses...
November 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/29134564/seom-clinical-guideline-for-treatment-of-kidney-cancer-2017
#17
E Gallardo, M J Méndez-Vidal, J L Pérez-Gracia, J M Sepúlveda-Sánchez, M Campayo, I Chirivella-González, X García-Del-Muro, A González-Del-Alba, E Grande, C Suárez
The goal of this article is to provide recommendations about the management of kidney cancer. Based on pathologic and molecular features, several kidney cancer variants were described. Nephron-sparing techniques are the gold standard of localized disease. After a randomized trial, sunitinib could be considered in adjuvant treatment in high-risk patients. Patients with advanced disease constitute a heterogeneous population. Prognostic classification should be considered. Both sunitinib and pazopanib are the standard options for first-line systemic therapy in advanced renal cell carcinoma...
November 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29132746/diabetes-mellitus-as-a-poor-mobilizer-condition
#18
REVIEW
Gian Paolo Fadini, John F DiPersio
Hematopoietic stem cell (HSC) transplantation in an effective and curative therapy for numerous hematological malignancies. Mobilization of HSCs from bone marrow (BM) to peripheral blood (PB) followed by apheresis is the gold standard for obtaining HSCs for both autologous and allogeneic stem cell transplantation. After administration of granulocyte-colony stimulating factor (G-CSF), up to 30% of patients fail to mobilize "optimal" numbers of HSCs required for engraftment. This review summarizes the current experimental and clinical evidence that diabetes mellitus is a risk factor for poor mobilization...
November 8, 2017: Blood Reviews
https://www.readbyqxmd.com/read/29132064/patients-and-caregivers-contributions-for-differentiating-epileptic-from-psychogenic-nonepileptic-seizures-value-and-limitations-of-self-reporting-questionnaires-a-pilot-study
#19
Giuseppe Erba, Elisa Bianchi, Giorgia Giussani, John Langfitt, Adam Juersivich, Ettore Beghi
PURPOSE: Questionnaires investigating semiology and comorbidities of psychogenic non-epileptic seizures (PNES) have been used mainly to help physicians expedite referrals to epilepsy centres for confirmation of diagnosis rather than as alternative diagnostic tool when video-EEG monitoring (VEM), the current gold standard, is not available or is inconclusive. METHODS: We developed one structured questionnaire for patients, exploring subjective experiences and vulnerabilities and one for eyewitnesses, focused on features observable during typical events to study prospectively 50 consecutive adult patients with PNES or epileptic seizures (ES) admitted for VEM...
November 8, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29131400/evaluation-of-3-serological-tests-for-early-detection-of-leptospira-specific-antibodies-in-experimentally-infected-dogs
#20
J Lizer, S Velineni, A Weber, M Krecic, P Meeus
BACKGROUND: Leptospirosis in dogs is a disease of global importance. Early detection and appropriate therapeutic intervention are necessary to resolve infection and prevent zoonotic transmission. However, its diagnosis is hindered by nonspecific clinical signs and lack of rapid diagnostic tests of early infection. Recently, 2 rapid point-of-care tests (WITNESS Lepto [WITNESS Lepto, Zoetis LLC, Kalamazoo, MI, USA] and SNAP Lepto [SNAP Lepto, IDEXX Laboratories, Westbrook, ME, USA]) for detection of Leptospira-specific antibodies in canine sera were developed...
November 13, 2017: Journal of Veterinary Internal Medicine
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