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https://www.readbyqxmd.com/read/28108664/an-investigation-of-the-genotoxicity-and-interference-of-gold-nanoparticles-in-commonly-used-in-vitro-mutagenicity-and-genotoxicity-assays
#1
Jiya M George, Millicent Magogotya, Melissa A Vetten, Antoinette V Buys, Mary Gulumian
The suitability of 4 in vitro assays, commonly used for mutagenicity and genotoxicity assessment, was investigated in relation to treatment with 14 nm citrate-stabilized gold nanoparticles (AuNPs). Specifically, the Ames test was conducted without metabolic activation, where no mutagenic effects were observed. High resolution transmission electron microscopy and Cytoviva dark-field image analysis showed that AuNPs did not enter the bacterial cells, thus confirming the unreliability of the Ames test for nanoparticle mutagenicity studies...
January 20, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28107836/plasmon-induced-photoelectrochemical-biosensor-for-in-situ-real-time-measurement-of-biotin-streptavidin-binding-kinetics-under-visible-light-irradiation
#2
Jingchun Guo, Tomoya Oshikiri, Kosei Ueno, Xu Shi, Hiroaki Misawa
We developed a localized surface plasmon-induced visible light-responsive photoelectrochemical (PEC) biosensor using a titanium dioxide (TiO2) photoelectrode loaded with gold nanoislands (AuNIs) for in situ real-time measurement of biotin-streptavidin association. As a proof of concept, self-assembled thiol-terminated biotin molecules bound on a AuNIs/TiO2 photoelectrode were successfully utilized to explore the photocurrent response to streptavidin-modified gold nanoparticle (STA-AuNP) solutions. This plasmon-induced PEC biosensor is simple and easy to miniaturize...
March 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28106826/colorectal-carcinoma-a-general-overview-and-future-perspectives-in-colorectal-cancer
#3
REVIEW
Inés Mármol, Cristina Sánchez-de-Diego, Alberto Pradilla Dieste, Elena Cerrada, María Jesús Rodriguez Yoldi
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death. Most cases of CRC are detected in Western countries, with its incidence increasing year by year. The probability of suffering from colorectal cancer is about 4%-5% and the risk for developing CRC is associated with personal features or habits such as age, chronic disease history and lifestyle. In this context, the gut microbiota has a relevant role, and dysbiosis situations can induce colonic carcinogenesis through a chronic inflammation mechanism...
January 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28106612/the-brief-early-childhood-screening-assessment-preliminary-validity-in-pediatric-primary-care
#4
Elise M Fallucco, Tim Wysocki, Lauren James, Chelsea Kozikowski, Andre Williams, Mary M Gleason
OBJECTIVE: Brief, well-validated instruments are needed to facilitate screening for early childhood behavioral and emotional problems (BEPs). The objectives of this study were to empirically reduce the length of the Early Childhood Screening Assessment (ECSA) and to assess the validity and reliability of this shorter tool. METHODS: Using caregiver ECSA responses for 2467 children aged 36 to 60 months seen in primary care, individual ECSA items were ranked on a scale ranging from "absolutely retain" to "absolutely delete...
January 17, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28105603/resuscitation-fluid-composition-affects-hepatic-inflammation-in-a-murine-model-of-early-sepsis
#5
Amanda L Patrick, Peter M Grin, Nicole Kraus, Michelle Gold, Matthew Berardocco, Patricia C Liaw, Alison E Fox-Robichaud
BACKGROUND: Fluid resuscitation is a crucial therapy for sepsis, and the use of balanced fluids and/or isotonic albumin may improve patient survival. We have previously demonstrated that resuscitation with normal saline results in increased hepatic leukocyte recruitment in a murine model of sepsis. Given that clinical formulations of albumin are in saline, our objectives were to develop a novel balanced electrolyte solution specifically for sepsis and to determine if supplementing this solution with albumin would improve the inflammatory response in sepsis...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28102972/evaluating-the-clinical-copd-questionnaire-a-systematic-review
#6
REVIEW
Zijing Zhou, Aiyuan Zhou, Yiyang Zhao, Ping Chen
The Clinical COPD Questionnaire (CCQ) is recommended by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) to evaluate health status in patients with COPD. The objective of this work was to systemically assess the reliability, validity, responsiveness and minimum clinically important difference (MCID) of the CCQ. A structured search was conducted in three databases to identify articles that evaluated the psychometric properties of the CCQ in individuals with COPD. Two investigators screened the title, abstract and full text of the articles to determine study eligibility and performed the data extraction...
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28102955/compound-speckle-model-detects-anti-angiogenic-tumor-response-in-preclinical-nonlinear-contrast-enhanced-ultrasonography
#7
Matthew R Lowerison, Justin J Tse, M Nicole Hague, Ann F Chambers, David W Holdsworth, James C Lacefield
PURPOSE: This paper proposes a method for analyzing the first-order speckle statistics of nonlinear contrast-enhanced ultrasound images from tumors. METHODS: Contrast signal intensity is modeled as a compound distribution of exponential probability density functions with a gamma weighting function. The gamma probability weighting function serves as an approximation for log-normally distributed flow velocities in a vascular network. The model was applied to sub-harmonic bolus-injection images acquired from a mouse breast cancer xenograft model treated with murine version bevacizumab...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102751/extracellular-vesicles-from-activated-platelets-a-semiquantitative-cryo-electron-microscopy-and-immuno-gold-labeling-study
#8
Alain R Brisson, Sisareuth Tan, Romain Linares, Céline Gounou, Nicolas Arraud
Cells release membrane vesicles in their surrounding medium either constitutively or in response to activating signals. Two main types of extracellular vesicles (EVs) are commonly distinguished based on their mechanism of formation, membrane composition and size. According to the current model, EVs shed from the plasma membrane, often called microvesicles, expose phosphatidylserine (PS) and range in size from 100 nm to 1 µm, while EVs originating from endosomal multi-vesicular bodies, called exosomes, contain tetraspanin proteins, including CD63, and range in size from 50 to 100 nm...
January 19, 2017: Platelets
https://www.readbyqxmd.com/read/28101415/endoscopic-sensing-of-alveolar-ph
#9
D Choudhury, M G Tanner, S McAughtrie, F Yu, B Mills, T R Choudhary, S Seth, T H Craven, J M Stone, I K Mati, C J Campbell, M Bradley, C K I Williams, K Dhaliwal, T A Birks, R R Thomson
Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ± 0...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28100496/preexisting-immunity-not-frailty-phenotype-predicts-influenza-post-vaccination-titers-among-older-veterans
#10
Puja Van Epps, Terrence Tumpey, Melissa B Pearce, Hana Golding, Patricia Higgins, Thomas Hornick, Christopher Burant, Brigid M Wilson, Richard Banks, Stefan Gravenstein, David H Canaday
Both preexisting immunity to influenza and age have been shown to be a correlate of influenza vaccine response. Frailty, an indicator of functional impairment in older adults, has also been shown in one study to predict lower influenza vaccine responses among non-veterans. In the current study we aimed to determine the association between frailty, preexisting immunity and immune response to influenza vaccine in older veterans. We analyzed 117 subjects (age range 62-95 years; median 81) divided into 3 cohorts based on the Fried frailty test: non-frail (NF: N=23; median age 68), pre-frail (PF: N=50; median age 80) and frail (F:N=44; median age 82) during the 2010-2011 and 11-12 influenza seasons...
January 18, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28100479/evidence-of-central-sensitisation-in-those-with-dry-eye-symptoms-and-neuropathic-like-ocular-pain-complaints-incomplete-response-to-topical-anaesthesia-and-generalised-heightened-sensitivity-to-evoked-pain
#11
Ashley M Crane, William Feuer, Elizabeth R Felix, Roy C Levitt, Allison L McClellan, Konstantinos D Sarantopoulos, Anat Galor
OBJECTIVE: To evaluate how closely neuropathic-like ocular pain (NOP) symptoms align with a metric of central sensitisation (ie, the presence of persistent ocular pain after topical anaesthetic placement) in individuals with dry eye (DE) symptoms. DESIGN: Cross-sectional study of 224 individuals with DE symptoms seen in the Miami Veterans Affairs eye clinic. An evaluation was performed consisting of questionnaires regarding DE symptoms, NOP descriptors and evoked pain sensitivity testing on the forehead and forearm, followed by a comprehensive ocular surface examination including corneal mechanical sensitivity testing...
January 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28099487/metabolic-imaging-of-head-and-neck-cancer-organoids
#12
Amy T Shah, Tiffany M Heaster, Melissa C Skala
Head and neck cancer patients suffer from toxicities, morbidities, and mortalities, and these ailments could be minimized through improved therapies. Drug discovery is a long, expensive, and complex process, so optimized assays can improve the success rate of drug candidates. This study applies optical imaging of cell metabolism to three-dimensional in vitro cultures of head and neck cancer grown from primary tumor tissue (organoids). This technique is advantageous because it measures cell metabolism using intrinsic fluorescence from NAD(P)H and FAD on a single cell level for a three-dimensional in vitro model...
2017: PloS One
https://www.readbyqxmd.com/read/28098979/electroactive-self-assembled-monolayers-detect-micelle-formation
#13
Eric R Dionne, Antonella Badia
The interfacial electrochemistry of self-assembled monolayers (SAMs) of ferrocenyldodecanethiolate on gold (FcC12SAu) electrodes is applied to detect the micellization of some common anionic surfactants, sodium n-alkyl sulfates, sodium n-alkyl sulfonates, sodium diamyl sulfosuccinate, and sodium dodecanoate, in aqueous solution by cyclic voltammetry. The apparent formal redox potential (Eº´SAM) of the FcC12SAu SAM is used to track changes in the concentration of the unaggregated surfactant anions and determine the critical micelle concentration (cmc)...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28098266/self-assembled-lipoprotein-based-gold-nanoparticles-for-detection-and-photothermal-disaggregation-of-%C3%AE-amyloid-aggregates
#14
P A T Martins, S Alsaiari, K Julfakyan, Z Nie, N M Khashab
We present a reconstituted lipoprotein-based nanoparticle platform comprising a curcumin fluorescent motif and an NIR responsive gold core. This multifunctional nanosystem is successfully used for aggregation-dependent fluorescence detection and photothermal disassembly of insoluble amyloid aggregates.
January 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28095682/superparamagnetic-nanoparticles-as-high-efficiency-magnetic-resonance-imaging-t2-contrast-agent
#15
Fernanda Sousa, Barbara Sanavio, Alessandra Saccani, Yun Tang, Ileana Zucca, Tamara M Carney, Alfonso Mastropietro, Paulo H Jacob Silva, Randy P Carney, Kurt Schenk, Arash O Omrani, Ping Huang, Lin Yang, Henrik M Rønnow, Francesco Stellacci, Silke Krol
Nanoparticle-based magnetic resonance imaging T2 negative agents are of great interest, and much effort is devoted to increasing cell-loading capability while maintaining low cytotoxicity. Herein, two classes of mixed-ligand protected magnetic-responsive, bimetallic gold/iron nanoparticles (Au/Fe NPs) synthesized by a two-step method are presented. Their structure, surface composition, and magnetic properties are characterized. The two classes of sulfonated Au/Fe NPs, with an average diameter of 4 nm, have an average atomic ratio of Au to Fe equal to 7 or 8, which enables the Au/Fe NPs to be superparamagnetic with a blocking temperature of 56 K and 96 K...
January 18, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28095556/combination-therapy-for-acne-scarring-personal-experience-and-clinical-suggestions
#16
Lucija Kroepfl, Jason J Emer
Acne is one of the most prevalent skin conditions seen by dermatologists. The cosmetic sequelae of severe acne, including scarring and pigmentation, have a profound psychological impact on those in icted. Topical (eg, retinoids, antibiotics, dapsone, hydroxyacids) and oral treatments (eg, antibiotics and/or spironolactone) are often bene cial to control acne or in the instance of oral isotretinoin use, rid the acne permanently; however, these treatments have very little affect on the ultimate cosmetic outcome of the acne scarring and skin texture that results...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28094940/high-electronic-conductance-through-double-helix-dna-molecules-with-fullerene-anchoring-groups
#17
Kathia Lorena Jiménez-Monroy, Nicolas Renaud, Jeroen Drijkoningen, David Cortens, Christian Van Haesendonck, Wanda Julienne Guedens, Koen Schouteden, Jean V Manca, Laurens D A Siebbeles, Ferdinand C Grozema, Patrick Hermann Wagner
Determining the mechanism of charge transport through native DNA remains a challenge as different factors such as measuring conditions, molecule conformations and choice of technique can significantly affect the final results. In this contribution, we have used a new approach to measure current flowing through isolated double-stranded DNA molecules, using fullerene groups to anchor the DNA to a gold substrate. Measurements were performed at room temperature in an inert environment using a conductive AFM technique...
January 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28094243/linear-and-ultrafast-nonlinear-plasmonics-of-single-nano-objects
#18
Aurelien Crut, Paolo Maioli, Fabrice Vallee, Natalia Del Fatti
Single-particle optical investigations have greatly improved our understanding of the fundamental properties of nano-objects, avoiding the spurious inhomogeneous effects that affect ensemble experiments. Correlation with high-resolution imaging techniques providing morphological information (e.g., electron microscopy) allows a quantitative interpretation of the optical measurements by means of analytical models and numerical simulations. In this topical review, we first briefly recall the principles underlying some of the most commonly used single-particle optical techniques: near-field, dark-field, spatial modulation and photothermal microscopies/spectroscopies...
January 17, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28093634/international-osteoporosis-foundation-and-european-calcified-tissue-society-working-group-recommendations-for-the-screening-of-adherence-to-oral-bisphosphonates
#19
A Diez-Perez, K E Naylor, B Abrahamsen, D Agnusdei, M L Brandi, C Cooper, E Dennison, E F Eriksen, D T Gold, N Guañabens, P Hadji, M Hiligsmann, R Horne, R Josse, J A Kanis, B Obermayer-Pietsch, D Prieto-Alhambra, J-Y Reginster, R Rizzoli, S Silverman, M C Zillikens, R Eastell
: Adherence to oral bisphosphonates is low. A screening strategy is proposed based on the response of biochemical markers of bone turnover after 3 months of therapy. If no change is observed, the clinician should reassess the adherence to the treatment and also other potential issues with the drug. INTRODUCTION: Low adherence to oral bisphosphonates is a common problem that jeopardizes the efficacy of treatment of osteoporosis. No clear screening strategy for the assessment of compliance is widely accepted in these patients...
January 16, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28093508/vertical-sleeve-gastrectomy-reduces-blood-pressure-and-hypothalamic-endoplasmic-reticulum-stress-in-mice
#20
Anne K McGavigan, Zachariah M Henseler, Darline Garibay, Scott D Butler, Sisitha Jayasinghe, Ruth E Ley, Robin L Davisson, Bethany P Cummings
Bariatric surgery, such as vertical sleeve gastrectomy (VSG), causes remarkable improvements in cardiometabolic health, including hypertension remission. However, the mechanisms responsible remain undefined and poorly studied. Therefore, we developed and validated the first murine model of VSG that recapitulates the blood pressure lowering effect of VSG using gold-standard radiotelemetry technology. We used this model to investigate several potential mechanisms, including body weight, brain endoplasmic reticulum (ER) stress signaling and brain inflammatory signaling, all critical contributors to obesity-associated hypertension pathogenesis...
January 12, 2017: Disease Models & Mechanisms
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