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Cardiac short term memory

Elodie Picarda, Séverine Bézie, Laetitia Boucault, Elodie Autrusseau, Stéphanie Kilens, Dimitri Meistermann, Bernard Martinet, Véronique Daguin, Audrey Donnart, Eric Charpentier, Laurent David, Ignacio Anegon, Carole Guillonneau
Rat and human CD4(+) and CD8(+) Tregs expressing low levels of CD45RC have strong immunoregulatory properties. We describe here that human CD45 isoforms are nonredundant and identify distinct subsets of cells. We show that CD45RC is not expressed by CD4(+) and CD8(+) Foxp3(+) Tregs, while CD45RA/RB/RO are. Transient administration of a monoclonal antibody (mAb) targeting CD45RC in a rat cardiac allotransplantation model induced transplant tolerance associated with inhibition of allogeneic humoral responses but maintained primary and memory responses against cognate antigens...
February 9, 2017: JCI Insight
Athina Zafeiriou, Guido H E Gendolla
Based on previous research on implicit effects on effort-related cardiovascular response and evidence that aging is associated with cognitive difficulties, we tested whether the mere activation of the aging stereotype can systematically influence young individuals' effort-mobilization during cognitive performance. Young participants performed an objectively difficult short-term memory task during which they processed elderly vs. youth primes and expected low vs. high incentive for success. When participants processed elderly primes during the task, we expected cardiovascular response to be weak in the low-incentive condition and strong in the high-incentive condition...
January 26, 2017: International Journal of Psychophysiology
Magdalena Jaszke-Psonka, Magdalena Piegza, Piotr Ścisło, Robert Pudlo, Jacek Piegza, Karina Badura-Brzoza, Aleksandra Leksowska, Robert T Hese, Piotr W Gorczyca
AIM: To evaluate the incidence and severity of the impairment of selected cognitive functions in patients after sudden cardiac arrest (SCA) in comparison to patients after myocardial infarction without SCA and healthy subjects and to analyze the influence of sociodemographic and clinical parameters and the duration of cardiac arrest on the presence and severity of the described disorders. MATERIAL AND METHODS: The study group comprised 30 cardiac arrest survivors, the reference group comprised 31 survivors of myocardial infarction without cardiac arrest, and the control group comprised 30 healthy subjects...
December 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
Julia L Sobesky, Heather M D'Angelo, Michael D Weber, Nathan D Anderson, Matthew G Frank, Linda R Watkins, Steven F Maier, Ruth M Barrientos
The impact of the foods we eat on metabolism and cardiac physiology has been studied for decades, yet less is known about the effects of foods on the CNS, or the behavioral manifestations that may result from these effects. Previous studies have shown that long-term consumption of high-fat foods leading to diet-induced obesity sensitizes the inflammatory response of the brain to subsequent challenging stimuli, causing deficits in the formation of long-term memories. The new findings reported here demonstrate that short-term consumption of a high-fat diet (HFD) produces the same outcomes, thus allowing the examination of mechanisms involved in this process long before obesity and associated comorbidities occur...
July 2016: ENeuro
W-F Li, T-L Lin, T-J Tan, R B Alikhanov, C-C Yong, S-H Wang, C-C Lin, Y-W Liu, C-C Wang, C-L Chen
BACKGROUND: Recipient hepatectomy can be complicated by severe bleeding during caudate lobe dissection in living-donor liver transplantation (LDLT), especially when the inferior vena cava is encased or with dense adhesions from prior interventions. Total hepatic vascular exclusion (TVE) including total hepatic inflow (Pringle maneuver) and occlusion of supra- and infra-hepatic inferior vena cava during the partial hepatectomy has been studied well, but it has not been mentioned regarding recipient hepatectomy in LDLT...
May 2016: Transplantation Proceedings
Paolo Centofanti, Cristina Barbero, Federico D'Agata, Marcella M Caglio, Paola Caroppo, Alessandro Cicerale, Matteo Attisani, Michele La Torre, Alberto Milan, Maria Luisa Contristano, Elena Carlini, Gennaro Izzo, Paolo Mortara, Franco Veglio, Mauro Rinaldi
BACKGROUND: Neurologic injury is still a frequent cause of mortality, morbidity, and long-lasting disability in patients undergoing an aortic arch operation with hypothermic circulatory arrest. The aim of this analysis was to evaluate short- and long-term outcomes in neurologic and cognitive functions in this group of high-risk patients. METHODS: A total of 333 patients undergoing an aortic arch operation between February 2004 and June 2010 were retrospectively reviewed...
September 2016: Surgery
Mathieu Chatelain, Guido H E Gendolla
Integrating the implicit-affect-primes-effort model (Gendolla, 2012, 2015) with the principles of motivational intensity theory (Brehm & Self, 1989) we investigated if the effort mobilization deficit observed in people exposed to fear primes (vs. anger primes) in a difficult short-term memory task could be compensated by high monetary incentive. Effort was operationalized as cardiac response. We expected that fear primes should lead to the strongest cardiac pre-ejection period (PEP) reactivity when incentive was high (high subjective demand and high justified effort) and to the weakest response when incentive was low (high subjective demand but only low justified effort)...
May 2016: Biological Psychology
Hideaki Kanazawa, Eleni Tseliou, James F Dawkins, Geoffrey De Couto, Romain Gallet, Konstantinos Malliaras, Kristine Yee, Michelle Kreke, Ileana Valle, Rachel R Smith, Ryan C Middleton, Chak-Sum Ho, Rohan Dharmakumar, Debiao Li, Raj R Makkar, Keiichi Fukuda, Linda Marbán, Eduardo Marbán
BACKGROUND: Infusion of allogeneic cardiosphere-derived cells (allo-CDCs) postreperfusion elicits cardioprotective cellular postconditioning in pigs with acute myocardial infarction. However, the long-term effects of allo-CDCs have not been assessed. We performed a placebo-controlled pivotal study for long-term evaluation, as well as shorter-term mechanistic studies. METHODS AND RESULTS: Minipigs underwent 1.5-hour mid-left anterior descending balloon occlusion followed by reperfusion and were randomized to receive intracoronary allo-CDCs or vehicle 30 minutes postreperfusion...
February 8, 2016: Journal of the American Heart Association
Piotr Futyma, Marian Futyma, Piotr Kułakowski
BACKGROUND: The use of an implantable cardioverter defibrillator (ICD) is a widely used and effective therapy, which reduces the risk of cardiac death in many cardiac diseases, both implanted for secondary and primary prevention. However, recurrent arrhythmias and ICD discharges have adverse prognostic significance. Additional parameters that would identify patients who are at increased risk of arrhythmias and appropriate ICD interventions would be of clinical value. Modern ICDs are relatively complex devices with a number of functions, including the possibility to perform noninvasive programmed stimulation (NIPS) with an implanted electrode located in the right ventricle...
January 27, 2016: Trials
Suzanne L Miller, Petra S Huppi, Carina Mallard
Fetal growth restriction (FGR) is a significant complication of pregnancy describing a fetus that does not grow to full potential due to pathological compromise. FGR affects 3-9% of pregnancies in high-income countries, and is a leading cause of perinatal mortality and morbidity. Placental insufficiency is the principal cause of FGR, resulting in chronic fetal hypoxia. This hypoxia induces a fetal adaptive response of cardiac output redistribution to favour vital organs, including the brain, and is in consequence called brain sparing...
February 15, 2016: Journal of Physiology
Kevin N Oguayo, Ola O Oyetayo, David Stewart, Steven M Costa, Richard O Jones
Out-of-hospital cardiac arrest is a leading cause of death in the United States. Pregnant women are not immune to cardiac arrest, and the treatment of such patients can be difficult. Pregnancy is a relative contraindication to the use of therapeutic hypothermia after cardiac arrest. A 20-year-old woman who was 18 weeks pregnant had an out-of-hospital cardiac arrest. Upon her arrival at the emergency department, she was resuscitated and her circulation returned spontaneously, but her score on the Glasgow Coma Scale was 3...
August 2015: Texas Heart Institute Journal
Yi-Hsin Chan, Wei-Chung Tsai, Jum-Suk Ko, Dechun Yin, Po-Cheng Chang, Michael Rubart, James N Weiss, Thomas H Everett, Shien-Fong Lin, Peng-Sheng Chen
BACKGROUND: Hypokalemia increases the vulnerability to ventricular fibrillation. We hypothesize that the apamin-sensitive small-conductance calcium-activated potassium current (IKAS) is activated during hypokalemia and that IKAS blockade is proarrhythmic. METHODS AND RESULTS: Optical mapping was performed in 23 Langendorff-perfused rabbit ventricles with atrioventricular block and either right or left ventricular pacing during normokalemia or hypokalemia. Apamin prolonged the action potential duration (APD) measured to 80% repolarization (APD80) by 26 milliseconds (95% confidence interval [CI], 14-37) during normokalemia and by 54 milliseconds (95% CI, 40-68) during hypokalemia (P=0...
October 13, 2015: Circulation
Anthony R Ward, Gabriela Alarcón, Joel T Nigg, Erica D Musser
Although attention deficit/hyperactivity disorder (ADHD) is associated with impairment in working memory and short-term memory, up to half of individual children with ADHD perform within a normative range. Heterogeneity in other ADHD-related mechanisms, which may compensate for or combine with cognitive weaknesses, is a likely explanation. One candidate is the robustness of parasympathetic regulation (as indexed by respiratory sinus arrhythmia; RSA). Theory and data suggest that a common neural network is likely tied to both heart-rate regulation and certain cognitive functions (including aspects of working and short-term memory)...
November 2015: Journal of Abnormal Child Psychology
Aurora M Lybeck, Hawnwan Philip Moy, David K Tan
A 40-year-old male struck his chest against a pole during a basketball game and had sudden out-of-hospital cardiac arrest. After bystander cardiopulmonary resuscitation, fire and emergency medical services personnel provided six defibrillation attempts prior to emergency department arrival. A 7th attempt in the emergency department using a different vector was unsuccessful. On the 8th attempt, using a second defibrillator with defibrillator pads placed adjacent to the primary set of defibrillator pads, two shocks were administered in near simultaneous fashion...
2015: Prehospital Emergency Care
Eirik Alnes Buanes, Arne Gramstad, Karoline Kjellsdotter Søvig, Karl Ove Hufthammer, Hans Flaatten, Thomas Husby, Jørund Langørgen, Jon-Kenneth Heltne
AIM: Neuropsychological testing has uncovered cognitive impairment in cardiac arrest survivors with good neurologic outcome according to the cerebral performance categories. We investigated cognitive function and health-related quality of life four years after cardiac arrest. METHODS: Thirty cardiac arrest survivors over the age of 18 in cerebral performance category 1 or 2 on hospital discharge completed the EQ-5D-5L and HADS questionnaires prior to cognitive testing using the Cambridge Neuropsychological Test Automated Battery...
April 2015: Resuscitation
Patrick Sulzgruber, Andreas Kliegel, Cosima Wandaller, Thomas Uray, Heidrun Losert, Anton N Laggner, Fritz Sterz, Matthias Kliegel
BACKGROUND: Deficits in cognitive function are a well-known dysfunction in survivors of cardiac arrest. However, data concerning memory function in this neurological vulnerable patient collective remain scarce and inconclusive. Therefore, we aimed to assess multiple aspects of retrospective and prospective memory performance in patients after cardiac arrest. METHODS: We prospectively enrolled 33 survivors of cardiac arrest, with cerebral performance categories (CPC) 1 and 2 and a control-group (n=33) matched in sex, age and educational-level...
March 2015: Resuscitation
Judith A Hudetz, Kathleen M Patterson, Zafar Iqbal, Sweeta D Gandhi, Paul S Pagel
OBJECTIVE: Remote ischemic preconditioning (RIPC) exerts neuroprotective effects in models of cerebral ischemia-reperfusion injury. The authors tested the hypothesis that RIPC decreases the incidence of postoperative delirium and prevents deterioration of short-term postoperative cognitive function in isoflurane-fentanyl-anesthetized patients undergoing cardiac surgery using cardiopulmonary bypass (CPB). DESIGN: Randomized, blinded, single-center pilot investigation...
April 2015: Journal of Cardiothoracic and Vascular Anesthesia
Ning Wei, Yoichiro Mori, Elena G Tolkacheva
Alternans is the periodic beat-to-beat short-long alternation in action potential duration (APD), which is considered to be a precursor of ventricular arrhythmias and sudden cardiac death. In extended cardiac tissue, electrical alternans can be either spatially concordant (SCA, all cells oscillate in phase) or spatially discordant (SDA, cells in different regions oscillate out of phase). SDA gives rise to an increase in the spatial dispersion of repolarization, which is thought to be proarrhythmic. In this paper, we investigated the effect of two aspects of short term memory (STM) (α, τ) and their interplay with conduction velocity (CV) restitution on alternans formation using numerical simulations of a mapping model with two beats of memory...
February 21, 2015: Journal of Theoretical Biology
Amadeu Quelhas Martins, David McIntyre, Christopher Ring
Activation of arterial baroreceptors can affect cortical activity. Cardiac cycle time studies have established that natural variations in baroreceptor activation are associated with changes in basic sensorimotor function whereas few have investigated more complex cognitive function. Aiming to improve our understanding of this phenomenon, this study examined performance on the Sternberg memory task as a function of the phase of the cardiac cycle. In each trial, participants were shown either two or six digits followed by a probe digit that either had or had not been presented previously and were required to press one of two response buttons to indicate a match and mismatch, respectively...
December 2014: Biological Psychology
Jake W Anderson, Elisabeth A Lambert, Carolina I Sari, Tye Dawood, Murray D Esler, Gautam Vaddadi, Gavin W Lambert
The Postural Orthostatic Tachycardia Syndrome (POTS) is a condition in which heart rate increases abnormally when the individual assumes an upright position. In addition to the marked tachycardia, presyncope, and syncope, patients with POTS often complain of light-headedness, fatigue, and difficulty in concentrating. The present study assessed individuals with POTS for psychiatric comorbidity, anxiety sensitivity and health related quality of life and examined general cognitive ability. Data was obtained from patients with POTS (n = 15, 12 female, aged 30 ± 3 years) and age matched healthy subjects (n = 30, 21 female, aged 32 ± 2 years)...
2014: Frontiers in Physiology
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