David G Schaeffer, John W Cain, Daniel J Gauthier, Soma S Kalb, Robert A Oliver, Elena G Tolkacheva, Wenjun Ying, Wanda Krassowska
Many features of the sequence of action potentials produced by repeated stimulation of a patch of cardiac muscle can be modeled by a 1D mapping, but not the full behavior included in the restitution portrait. Specifically, recent experiments have found that (i) the dynamic and S1-S2 restitution curves are different (rate dependence) and (ii) the approach to steady state, which requires many action potentials (accommodation), occurs along a curve distinct from either restitution curve. Neither behavior can be produced by a 1D mapping...
February 2007: Bulletin of Mathematical Biology