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https://www.readbyqxmd.com/read/27686411/management-of-a-patient-with-acute-acetabular-labral-tear-and-femoral-acetabular-impingement-with-intra-articular-steroid-injection-and-a-neuromotor-training-program
#1
Joel R Narveson, Matthew D Haberl, Patrick J Grabowski
Study Design Case report. Background Intra-articular hip pathologies can be difficult to diagnose, and evidence to guide physical therapy interventions is lacking. The purpose of this case report is to describe a clinical pathway for conservative management of a patient with an acute acetabular labral tear and femoroacetabular impingement. Case Description The patient was an 18-year-old woman with recent onset of right groin pain who underwent intra-articular corticosteroid injection and therapeutic exercise for the management of an acute acetabular labral tear identified on radiographic imaging...
November 2016: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/27629403/the-warwick-agreement-on-femoroacetabular-impingement-syndrome-fai-syndrome-an-international-consensus-statement
#2
D R Griffin, E J Dickenson, J O'Donnell, R Agricola, T Awan, M Beck, J C Clohisy, H P Dijkstra, E Falvey, M Gimpel, R S Hinman, P Hölmich, A Kassarjian, H D Martin, R Martin, R C Mather, M J Philippon, M P Reiman, A Takla, K Thorborg, S Walker, A Weir, K L Bennell
The 2016 Warwick Agreement on femoroacetabular impingement (FAI) syndrome was convened to build an international, multidisciplinary consensus on the diagnosis and management of patients with FAI syndrome. 22 panel members and 1 patient from 9 countries and 5 different specialties participated in a 1-day consensus meeting on 29 June 2016. Prior to the meeting, 6 questions were agreed on, and recent relevant systematic reviews and seminal literature were circulated. Panel members gave presentations on the topics of the agreed questions at Sports Hip 2016, an open meeting held in the UK on 27-29 June...
October 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27594424/ezh2-coupled-with-hotair-to-silence-microrna-34a-by-the-induction-of-heterochromatin-formation-in-human-pancreatic-ductal-adenocarcinoma
#3
Chi-Han Li, Zhangang Xiao, Joanna Hung-Man Tong, Ka-Fai To, Xiangdong Fang, Alfred Sl Cheng, Yangchao Chen
MicroRNA-34a (miR-34a) is frequently downregulated in pancreatic ductal adenocarcinoma (PDAC) cells, however, the silencing mechanism remains unclear. Enhancer of zeste homolog 2 (EZH2) is overexpressed in PDAC, and our previous miRNA profiling showed that inhibition of EZH2 in PDAC cells led to the re-expression of a group of tumor suppressor miRNAs including miR-34a. Here, we studied the effect of ectopic EZH2 expression to the silencing of miR-34a, and identified HOTAIR as an interacting partner to induce heterochromatin formation during miR-34a repression...
January 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27173983/physical-therapy-protocol-after-hip-arthroscopy-clinical-guidelines-supported-by-2-year-outcomes
#4
Benjamin G Domb, Terrance A Sgroi, Jeremy C VanDevender
CONTEXT: Femoroacetabular impingement (FAI) was first described by Ganz in 2003 and is a significant cause of decreased function and mobility. Femoroacetabular impingement must be treated in an individualized, goal-oriented, stepwise fashion. This protocol was developed with biomechanical considerations of soft tissue and bony structures surrounding the hip joint. EVIDENCE ACQUISITION: The PubMed database was searched for scientific and review articles from the years 2000 to 2015 utilizing the search terms: hip rehabilitation, femoroacetabular impingement, and arthroscopy...
July 2016: Sports Health
https://www.readbyqxmd.com/read/27161070/clinical-and-surgical-correlation-of-hip-mr-arthrographic-findings-in-adolescents
#5
Anugayathri Jawahar, Aruna Vade, Laurie Lomasney, Gokcan Okur, Douglas Evans, Perla Subbaiah
OBJECTIVE: The purpose of this study was to analyze the utility of MRA-H in adolescents by comparing the results of imaging with surgical findings and/or clinical outcome. MATERIAL AND METHODS: After obtaining appropriate IRB approval, the Radiologic Information System database was queried for all patients 13-18 years of age who underwent MRA-H from 2004 through 2013. The electronic medical record was reviewed for clinical history, clinical examination findings, and operative notes...
June 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/26978483/evidence-based-clinical-use-of-nanoscale-extracellular-vesicles-in-nanomedicine
#6
Stefano Fais, Lorraine O'Driscoll, Francesc E Borras, Edit Buzas, Giovanni Camussi, Francesco Cappello, Joana Carvalho, Anabela Cordeiro da Silva, Hernando Del Portillo, Samir El Andaloussi, Tanja Ficko Trček, Roberto Furlan, An Hendrix, Ihsan Gursel, Veronika Kralj-Iglic, Bertrand Kaeffer, Maja Kosanovic, Marilena E Lekka, Georg Lipps, Mariantonia Logozzi, Antonio Marcilla, Marei Sammar, Alicia Llorente, Irina Nazarenko, Carla Oliveira, Gabriella Pocsfalvi, Lawrence Rajendran, Graça Raposo, Eva Rohde, Pia Siljander, Guillaume van Niel, M Helena Vasconcelos, María Yáñez-Mó, Marjo L Yliperttula, Natasa Zarovni, Apolonija Bedina Zavec, Bernd Giebel
Recent research has demonstrated that all body fluids assessed contain substantial amounts of vesicles that range in size from 30 to 1000 nm and that are surrounded by phospholipid membranes containing different membrane microdomains such as lipid rafts and caveolae. The most prominent representatives of these so-called extracellular vesicles (EVs) are nanosized exosomes (70-150 nm), which are derivatives of the endosomal system, and microvesicles (100-1000 nm), which are produced by outward budding of the plasma membrane...
April 26, 2016: ACS Nano
https://www.readbyqxmd.com/read/26846934/two-year-outcomes-after-arthroscopic-surgery-compared-to-physical-therapy-for-femoracetabular-impingement-a-protocol-for-a-randomized-clinical-trial
#7
Nancy S Mansell, Daniel I Rhon, Bryant G Marchant, John M Slevin, John L Meyer
BACKGROUND: As the prevalence of hip pathology in the younger athletic population rises, the medical community continues to investigate effective intervention options. Femoracetabular impingement is the morphologically abnormal articulation of the femoral head against the acetabulum, and often implicated in pre-arthritic hip conditions of musculoskeletal nature. Arthroscopic surgical decompression and non-surgical rehabilitation programs focused on strengthening and stability are common interventions...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/26816416/conservative-management-of-an-elite-ice-hockey-goaltender-with-femoroacetabular-impingement-fai-a-case-report
#8
Kyle MacIntyre, Brendan Gomes, Steven MacKenzie, Kevin D'Angelo
OBJECTIVE: To detail the presentation of an elite male ice hockey goaltender with cam-type femoroacetabular impingement (FAI) and acetabular labral tears. This case will outline the prevalence, clinical presentation, imaging criteria, pathomechanics, and management of FAI, with specific emphasis on the ice hockey goaltender. CLINICAL FEATURES: A 22-year old retired ice hockey goaltender presented to a chiropractor after being diagnosed by an orthopaedic surgeon with MRI confirmed left longitudinal and chondral flap acetabular labral tears and cam-type femoroacetabular impingement (FAI)...
December 2015: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/26556072/adult-neurogenic-and-antidepressant-effects-of-adiponectin-a-potential-replacement-for-exercise
#9
REVIEW
Ang Li, Suk-Yu Yau, Sergio Machado, Ti-Fei Yuan, Kwok-Fai So
Physical exercise has long been recognized to benefit locomotor and cardiovascular systems. Although an increasing body of evidence also suggests it to be an effective non-medicinal remedy for mental disorders such as depression, the underlying mechanisms remain elusive. A recent study has demonstrated that increases of the adipocyte-secreted hormone adiponectin in the central nervous system following exercise may be responsible for these neuropsychological changes, including enhanced generation of neurons in the adult hippocampus, as well as mitigation of depressive severity...
2015: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/26536659/phosphorylation-of-nucleophosmin-at-threonine-234-237-is-associated-with-hcc-metastasis
#10
Rachel Hiu Ha Ching, Eunice Yuen Ting Lau, Patrick Ming Tat Ling, Joyce Man Fong Lee, Mark Kin Fai Ma, Bowie Yik Ling Cheng, Regina Cheuk Lam Lo, Irene Oi Lin Ng, Terence Kin Wah Lee
Hepatocellular carcinoma (HCC) is frequently complicated by the occurrence of intrahepatic and extrahepatic metastases, leading to poor prognosis. To improve the prognosis for HCC patients, there is an urgent need to understand the molecular mechanisms of metastasis in HCC. Since protein Serine/Threonine phosphorylation emerges to be an important posttranslational modification critical in signaling process associated with cell proliferation, survival and metastasis, we employed a pair of primary tumor-derived and corresponding lung-metastatic counterparts (PLC/PRF/5-PT and PLC/PRF/5-LM) and aimed to identify these changes using CelluSpot Serine/Threonine kinase peptide array...
December 22, 2015: Oncotarget
https://www.readbyqxmd.com/read/26219994/sex-differences-in-patients-with-cam-deformities-with-femoroacetabular-impingement-3-dimensional-computed-tomographic-quantification
#11
Adam B Yanke, M Michael Khair, Robert Stanley, David Walton, Simon Lee, Charles A Bush-Joseph, Alejandro Espinoza Orías, Alejandro A Espinosa Orias, Nozomu Inoue, Shane J Nho
PURPOSE: To determine if significant differences exist between male and female CAM deformities using quantitative 3-dimensional (3D) volume and location analysis. METHODS: Retrospective analysis of preoperative computed tomographic (CT) scans for 138 femurs (69 from male patients and 69 from female patients) diagnosed with impingement from November 2009 to November 2011 was completed. Those patients who presented with hip complaints and had a history, physical examination (limited range of motion, positive impingement signs), plain radiographs (anteroposterior pelvis, 90° Dunn view, false profile view), and magnetic resonance images consistent with femoroacetabular impingement (FAI) and in whom a minimum of 6 months of conservative therapy (oral anti-inflammatory agents, physical therapy, and activity modification) had failed were indicated for arthroscopic surgery and had a preoperative CT scan...
December 2015: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/26004988/androgen-deprivation-therapy-diabetes-and-poor-physical-performance-status-increase-fracture-risk-in-chinese-men-treated-for-prostate-cancer
#12
Jeremy Yuen Chun Teoh, Peter Ka Fung Chiu, Samson Yun Sang Chan, Darren Ming Chun Poon, Ho-Yuen Cheung, Simon See Ming Hou, Chi-Fai Ng
We investigated the fracture risk after androgen deprivation therapy (ADT) for prostate cancer in the Chinese population. All Chinese prostate cancer patients who were treated primarily by radical prostatectomy or radiotherapy, with or without further ADT, from year 2000 to 2009 were reviewed. We compared the fracture risk in patients who were given ADT (ADT group) with those who were not given any ADT (non-ADT group). Potential risk factors including age, diabetes mellitus, hypertension, hyperlipidemia, ischemic heart disease and performance status were reviewed...
2015: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/25853634/vulvodynia-and-concomitant-femoro-acetabular-impingement-long-term-follow-up-after-hip-arthroscopy
#13
Deborah Coady, Stacey Futterman, Dena Harris, Struan H Coleman
OBJECTIVE: We hypothesized that in patients with vulvodynia and femoro-acetabular impingement (FAI), vulvar pain may be generated by the effect of FAI on pelvic floor structures, and treatment with arthroscopy may improve vulvodynia. We also sought to identify characteristics of patients whose vulvodynia improved after arthroscopy. MATERIALS AND METHODS: A case series of patients with vulvodynia and FAI underwent physical therapy, and, if hip symptoms did not improve, arthroscopy...
July 2015: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/25262968/femoroacetabular-impingement-in-skeletally-immature-patients-a-systematic-review-examining-indications-outcomes-and-complications-of-open-and-arthroscopic-treatment
#14
REVIEW
Darren de Sa, Stephanie Cargnelli, Michael Catapano, Asheesh Bedi, Nicole Simunovic, Sarah Burrow, Olufemi R Ayeni
PURPOSE: Improvements in physical examination and radiographic appreciation of symptomatic femoroacetabular impingement (FAI) has increased the focus on early diagnosis and treatment in an adolescent population. This systematic review aimed to establish specific indications, outcomes, and complications of surgical management of adolescent FAI. METHODS: The Medline, Embase, and PubMed online databases were searched from inception until April 21, 2014, for English-language studies that addressed open and/or arthroscopic treatment of FAI in patients aged 10 to 19 years inclusively...
February 2015: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/23886613/prevalence-of-and-associations-with-reduced-exercise-capacity-in-peritoneal-dialysis-patients
#15
Ming-Liang Zuo, Wen-Sheng Yue, Terence Yip, Flora Ng, Kwok-Fai Lam, Kai-Hang Yiu, Sing-Leung Lui, Hung-Fat Tse, Chung-Wah Siu, Wai-Kei Lo
BACKGROUND: Exercise capacity is reduced in patients with end-stage renal disease on maintenance home peritoneal dialysis therapy, although the potential mechanisms and clinical implications remain unclear. STUDY DESIGN: Cross-sectional study. SETTING & PARTICIPANTS: 95 ambulatory prevalent and incident peritoneal dialysis patients in a well-established renal dialysis center (mean age, 58.26 ± 12.6 [SD] years; 63% men; mean duration of peritoneal dialysis therapy, 3...
November 2013: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/23764784/hip-arthroscopy-and-femoroacetabular-impingement-in-the-pediatric-patient
#16
Marc J Philippon, Diana C Patterson, Karen K Briggs
Femoroacetabular impingement (FAI) is widely understood to be an underlying etiology of injuries to the acetabular labrum and cartilage in the adult hip, although somewhat less attention has previously been spent on its incidence in the pediatric and adolescent populations. Initially recognized as a consequence of periacetabular osteotomies performed for developmental dysplasia of the hip, it can also be because of a number of other disorders or to a developmental process causing irregular bony growth. The adolescent presenting with FAI is athletic, particularly in endeavors placing excessive stress on the hip and surrounding soft tissues...
July 2013: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/23594436/low-sex-hormone-binding-globulin-is-associated-with-hypertension-a-cross-sectional-study-in-a-swedish-population
#17
RANDOMIZED CONTROLLED TRIAL
Bledar Daka, Thord Rosen, Per Anders Jansson, Charlotte A Larsson, Lennart Råstam, Ulf Lindblad
BACKGROUND: The aim of this study was to investigate the association of sex hormone-binding globulin (SHBG) and hypertension in a Swedish population. METHODS: The study is based on a random sample of a Swedish population of men and women aged 30-74 years (n=2,816). Total testosterone, oestradiol and SHBG were measured in 2,782 participants. Free androgen index was then calculated according to the formula FAI=100 × (Total testosterone)/SHBG. Hypertension was diagnosed according to JNC7...
2013: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/23548135/condition-specific-measure-was-more-responsive-than-generic-measure-in-colorectal-cancer-all-but-social-domains
#18
COMPARATIVE STUDY
Carlos K Wong, Cindy L Lam, Wai-Lun Law, Jensen T Poon, Dora L Kwong, Janice Tsang, Yuk-Fai Wan
OBJECTIVE: To examine the responsiveness of generic and condition-specific instruments based on the anchor of self-reported level of global change in patients with colorectal cancer (CRC). STUDY DESIGN AND SETTING: Three hundred thirty-three patients with CRC were surveyed at two assessments at baseline and follow-up at 6 months from September 2009 to July 2010 using the Short Form-12 Health Survey version 2 (SF-12v2) and Functional Assessment of Cancer Therapy-Colorectal (FACT-C) measures...
May 2013: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/23546917/dumbbell-shaped-primitive-neuroectodermal-tumor-mimicking-trigeminal-schwannoma-a-case-report-and-review-of-literature
#19
Weng-Fai Lao, Ming-Dar Tsai
Primitive neuroectodermal tumor (PNET) is presumably of neural crest origin, and cases of supratentorial PNET in adult are extremely rare. We reported a case of PNET presenting as a dumbbell-shaped tumor at the middle cranial fossa of skull base mimicking trigeminal schwannoma both clinically and radiologically. The patient underwent surgery on July 13, 2010, using a combination of subtemporal, pterional and retrosigmoid approaches, to achieve decompression and obtain a histological diagnosis. The patient worsened neurologically two weeks after surgery...
2013: Turkish Neurosurgery
https://www.readbyqxmd.com/read/23419746/nonoperative-treatment-for-femoroacetabular-impingement-a-systematic-review-of-the-literature
#20
REVIEW
Peter D H Wall, Miguel Fernandez, Damian R Griffin, Nadine E Foster
OBJECTIVE: Femoroacetabular impingement (FAI) has been identified as a common cause of hip pain in young adults. However, it is not known whether an effective nonoperative treatment exists and whether there is any evidence to support such a treatment. The purpose of this review is to establish whether nonoperative treatments exist for FAI in the published literature and whether there is any evidence to support their use. TYPE: A systematic review. LITERACY SURVEY: PubMed, Medline, EMBASE, CINAHL, AMED, and Cochrane Library databases were searched by using the following terms: femoroacetabular impingement, femoro-acetabular impingement, and hip impingement...
May 2013: PM & R: the Journal of Injury, Function, and Rehabilitation
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