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https://www.readbyqxmd.com/read/29330419/parkinson-disease-with-constipation-clinical-features-and-relevant-factors
#1
Qiu-Jin Yu, Shu-Yang Yu, Li-Jun Zuo, Teng-Hong Lian, Yang Hu, Rui-Dan Wang, Ying-Shan Piao, Peng Guo, Li Liu, Zhao Jin, Li-Xia Li, Piu Chan, Sheng-Di Chen, Xiao-Min Wang, Wei Zhang
Constipation is one of the most frequent non-motor symptoms of Parkinson disease (PD) and it may be ignored by PD patients, leading to this problem not to be reported in time. The relationships between constipation and demographic variables, motor symptoms and other non-motor symptoms of PD are still unknown. PD patients were evaluated by diagnostic criteria of functional constipation in Rome III and divided into PD with constipation (PD-C) and PD with no constipation (PD-NC) groups. PD patients were assessed by rating scales of motor symptoms and other non-motor symptoms, activity of daily living and quality of life...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323626/a-scenario-based-cognitive-behavioral-therapy-mobile-app-to-reduce-dysfunctional-beliefs-in-individuals-with-depression-a-randomized-controlled-trial
#2
Ji-Won Hur, Boram Kim, Dasom Park, Sung-Won Choi
INTRODUCTION: While self-administered mobile app-based cognitive behavioral therapy (CBT) has shown efficiency and effectiveness over the past decade, attempts to address automatic and negative beliefs have been lacking. The purpose of this study was to introduce and verify a mobile app that directly intervenes in dysfunctional thoughts. This app-based treatment includes recognizing automatic and negative thoughts of the protagonist of scenarios, writing advice directly to the main character, and sharing advice provided by other participants...
January 11, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29323266/aif-loss-deregulates-hematopoiesis-and-reveals-different-adaptive-metabolic-responses-in-bone-marrow-cells-and-thymocytes
#3
Lauriane Cabon, Audrey Bertaux, Marie-Noëlle Brunelle-Navas, Ivan Nemazanyy, Laurianne Scourzic, Laure Delavallée, Laura Vela, Mathieu Baritaud, Sandrine Bouchet, Cécile Lopez, Vu Quang Van, Kevin Garbin, Danielle Chateau, Françoise Gilard, Marika Sarfati, Thomas Mercher, Olivier A Bernard, Santos A Susin
Mitochondrial metabolism is a tightly regulated process that plays a central role throughout the lifespan of hematopoietic cells. Herein, we analyze the consequences of the mitochondrial oxidative phosphorylation (OXPHOS)/metabolism disorder associated with the cell-specific hematopoietic ablation of apoptosis-inducing factor (AIF). AIF-null (AIF-/Y ) mice developed pancytopenia that was associated with hypocellular bone marrow (BM) and thymus atrophy. Although myeloid cells were relatively spared, the B-cell and erythroid lineages were altered with increased frequencies of precursor B cells, pro-erythroblasts I, and basophilic erythroblasts II...
January 11, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29320641/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-position-statement-on-testing-for-autonomic-and-somatic-nerve-dysfunction
#4
Aaron I Vinik, Pauline M Camacho, Jaime A Davidson, Yehuda Handelsman, Howard M Lando, Anne L Leddy, Sethu K Reddy, Richard Cook, Vicenza Spallone, Solomon Tesfaye, Dan Ziegler
This document represents the official position of the American Association of Clinical Endocrinologists and the American College of Endocrinology. Where there were no randomized controlled trials or specific U.S. FDA labeling for issues in clinical practice, the participating clinical experts utilized their judgment and experience. Every effort was made to achieve consensus among the committee members. Position statements are meant to provide guidance, but they are not to be considered prescriptive for any individual patient and cannot replace the judgment of a clinician...
December 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29316211/prehypertension-is-a-comorbid-state-with-autonomic-and-metabolic-dysfunction
#5
Mi-Hyang Jung, Sang-Hyun Ihm, Dong-Hyeon Lee, Young Choi, Woo-Baek Chung, Hae Ok Jung, Kyung-Soon Hong, Ho-Joong Youn
We aimed to elucidate the role of autonomic dysfunction in the context of complex metabolic and cardiovascular changes in subjects with prehypertension. We identified 556 asymptomatic subjects without hypertension who underwent comprehensive cardiovascular exams. We obtained heart rate recovery (HRR) after peak exercise to quantitatively measure autonomic dysfunction. Of the 556 participants, 279 individuals had prehypertension and the remaining 277 had optimal BP. HRR was significantly lower in the prehypertension group (36...
January 6, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29313228/extension-of-the-metabolic-syndrome-cluster
#6
S I Kseneva, E V Borodulina, V V Udut
In a one-stage cross-sectional study, a continuous sample of 102 patients (mean age 47.81±0.63 years) with metabolic syndrome was examined. It was found that autonomic dysfunction determines specific features of arterial hypertension in this group of patients, it causes cardiac autonomic neuropathy and underlies the mechanisms of lower urinary tract symptoms development.
January 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29309922/pyridostigmine-protects-against-cardiomyopathy-associated-with-adipose-tissue-browning-and-improvement-of-vagal-activity-in-high-fat-diet-rats
#7
Yi Lu, Qing Wu, Long-Zhu Liu, Xiao-Jiang Yu, Jin-Jun Liu, Man-Xiang Li, Wei-Jin Zang
Obesity, a major contributor to the development of cardiovascular diseases, is associated with an autonomic imbalance characterized by sympathetic hyperactivity and diminished vagal activity. Vagal activation plays important roles in weight loss and improvement of cardiac function. Pyridostigmine is a reversible acetylcholinesterase inhibitor, but whether it ameliorates cardiac lipid accumulation and cardiac remodeling in rats fed a high-fat diet has not been determined. This study investigated the effects of pyridostigmine on high-fat diet-induced cardiac dysfunction and explored the potential mechanisms...
January 5, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29306794/the-short-term-effects-of-indoor-size-fractioned-particulate-matter-and-black-carbon-on-cardiac-autonomic-function-in-copd-patients
#8
Lu Pan, Shaowei Wu, Hongyu Li, Junhui Xu, Wei Dong, Jiao Shan, Xuan Yang, Yahong Chen, Masayuki Shima, Furong Deng, Xinbiao Guo
BACKGROUND: Previous studies have reported adverse health effects of indoor air pollutants especially particulate matter (PM) and black carbon (BC). Patients with chronic obstructive pulmonary disease (COPD) have been shown to be more likely with cardiovascular comorbidities in which cardiac autonomic dysfunction plays an important role. However, there is little evidence for the effect of indoor PM and BC exposures on cardiac autonomic function in COPD patients. OBJECTIVES: To evaluate the association between exposure to indoor size-fractioned PM and BC and changes in HRV and HR in COPD patients...
January 3, 2018: Environment International
https://www.readbyqxmd.com/read/29306636/clinical-correlates-of-cerebral-white-matter-abnormalities-in-patients-with-parkinson-s-disease
#9
Bibet L Ten Harmsen, Anouke van Rumund, Marjolein B Aerts, Mayra I Bergkamp, Rianne A J Esselink, Edo Richard, Frederick J A Meijer, Bastiaan R Bloem, Daniel J van Wamelen
OBJECTIVE: To determine if autonomic dysfunction, cognitive disorders or axial disability are associated with white matter lesions (WML) in Parkinson disease (PD). METHODS: We performed a retrospective cross-sectional review study on 204 consecutive PD patients who underwent cerebral MRI in our center between January 2012 and July 2016. For each patient, we scored the severity of WML and PV (periventricular) WML using the Fazekas score and using the ARWMC scale for WML and BG (basal ganglia) and clinical characteristics such as neurogenic orthostatic hypotension and cognitive function...
December 27, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29305918/circadian-modification-network-of-a-core-clock-driver-bmal1-to-harmonize-physiology-from-brain-to-peripheral-tissues
#10
Teruya Tamaru, Ken Takamatsu
Circadian clocks dictate various physiological functions by brain SCN (a central clock) -orchestrating the temporal harmony of peripheral clocks of tissues/organs in the whole body, with adaptability to environments by resetting their timings. Dysfunction of this circadian adaptation system (CAS) occasionally causes/exacerbates diseases. CAS is based on cell-autonomous molecular clocks, which oscillate via a core transcriptional/translational feedback loop with clock genes/proteins, e.g., BMAL1: CLOCK circadian transcription driver and CRY1/2 and PER1/2 suppressors, and is modulated by various regulatory loops including clock protein modifications...
January 3, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29305815/autonomic-dysfunction-predicts-poor-outcome-in-stroke-updates-on-recent-autonomic-research
#11
EDITORIAL
Mitchell G Miglis, Srikanth Muppidi
No abstract text is available yet for this article.
January 5, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29305721/paragangliomas-arise-through-an-autonomous-vasculo-angio-neurogenic-program-inhibited-by-imatinib
#12
Fabio Verginelli, Silvia Perconti, Simone Vespa, Francesca Schiavi, Sampath Chandra Prasat, Paola Lanuti, Alessandro Cama, Lorenzo Tramontana, Diana Liberata Esposito, Simone Guarnieri, Artenca Sheu, Mattia Russel Pantalone, Rosalba Florio, Annalisa Morgano, Cosmo Rossi, Giuseppina Bologna, Marco Marchisio, Andrea D'Argenio, Elisa Taschin, Rosa Visone, Giuseppe Opocher, Angelo Veronese, Carlo T Paties, Vinalogu K Rajasekhar, Cecilia Söderberg-Nauclér, Mario Sanna, Lavinia Vittoria Lotti, Renato Mariani-Costantini
Tumours can be viewed as aberrant tissues or organs sustained by tumorigenic stem-like cells that engage into dysregulated histo/organogenetic processes. Paragangliomas, prototypical organoid tumours constituted by dysmorphic variants of the vascular and neural tissues found in normal paraganglia, provide a model to test this hypothesis. To understand the origin of paragangliomas, we built a biobank comprising 77 cases, 18 primary cultures, 4 derived cell lines, 80 patient-derived xenografts and 11 cell-derived xenografts...
January 5, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29304719/neuroimmunology-of-traumatic-brain-injury-a-longitudinal-study-of-interdependency-of-inflammatory-markers-and-heart-rate-variability-in-severe-traumatic-brain-injury
#13
Akhil Deepika, Bhagavatula Indira Devi, Dhaval P Shukla, Talakad N Sathyaprabla, Rita Christopher, Shruthi S Ramesh
The purpose of the present study is to evaluate the inter-dependency between the electrophysiological (Heart rate variability) and inflammatory markers in traumatic brain injury (TBI) patients and the outcome in patients with severe TBI. A prospective exploratory study was done with a sample size of 89 severe traumatic brain injury patients. The Heart rate variability of these patients was recorded using a telemetric device BioHarness® (Zephyr technologies). The recordings were made on day 1 of the patients' admission into the ICU followed by serial recordings on Day 3 and day 10...
January 5, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29303111/chronic-implantation-of-cuff-electrodes-on-the-pelvic-nerve-in-rats-is-well-tolerated-and-does-not-compromise-afferent-or-efferent-fibre-functionality
#14
Jonathan J Crook, Charly Brouillard, Pedro Irazoqui, Thelma Lovick
Objective Neuromodulation of autonomic nerve activity to regulate physiological processes is an emerging field. Vagal stimulation has received most attention whereas the potential of modulate visceral function by targeting autonomic nerves within the abdominal cavity remains under-exploited. Surgery to locate intra-abdominal targets is inherently more stressful than for peripheral nerves. Electrode leads risk becoming entrapped by intestines and loss of functionality in the nerve-target organ connection could result from electrode migration or twisting...
January 5, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29302618/time-restricted-feeding-improves-circadian-dysfunction-as-well-as-motor-symptoms-in-the-q175-mouse-model-of-huntington-s-disease
#15
Huei-Bin Wang, Dawn H Loh, Daniel S Whittaker, Tamara Cutler, David Howland, Christopher S Colwell
Huntington's disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction. Disturbances in sleep/wake cycles are common among HD patients with reports of delayed sleep onset, frequent bedtime awakenings, and fatigue during the day. The heterozygous Q175 mouse model of HD has been shown to phenocopy many HD core symptoms including circadian dysfunctions. Because circadian dysfunction manifests early in the disease in both patients and mouse models, we sought to determine if early intervention that improve circadian rhythmicity can benefit HD and delay disease progression...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29299712/cardiovascular-autonomic-dysfunction-in-sudden-infant-death-syndrome
#16
REVIEW
Rosemary S C Horne
A failure of cardiorespiratory control mechanisms, together with an impaired arousal response from sleep, are believed to play an important role in the final event of sudden infant death syndrome (SIDS). The 'triple risk model' describes SIDS as an event that results from the intersection of three overlapping factors: (1) a vulnerable infant, (2) a critical developmental period in homeostatic control and (3) an exogenous stressor. In an attempt to understand how the triple risk hypothesis is related to infant cardiorespiratory physiology, many researchers have examined how the known risk and protective factors for SIDS alter infant cardiovascular control during sleep...
January 3, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29298212/electrophysiology-of-cranial-nerve-testing-cranial-nerves-ix-and-x
#17
Alberto R M Martinez, Melina P Martins, Ana Lucila Moreira, Carlos R Martins, Paulo A T Kimaid, Marcondes C França
The cranial nerves IX and X emerge from medulla oblongata and have motor, sensory, and parasympathetic functions. Some of these are amenable to neurophysiological assessment. It is often hard to separate the individual contribution of each nerve; in fact, some of the techniques are indeed a composite functional measure of both nerves. The main methods are the evaluation of the swallowing function (combined IX and X), laryngeal electromyogram (predominant motor vagal function), and heart rate variability (predominant parasympathetic vagal function)...
January 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29297596/neuropathology-of-autonomic-dysfunction-in-synucleinopathies
#18
REVIEW
Elizabeth A Coon, Jeremy K Cutsforth-Gregory, Eduardo E Benarroch
The synucleinopathies-Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and pure autonomic failure-result from distinct patterns of abnormal α-synuclein aggregation throughout the nervous system. Autonomic dysfunction in these disorders results from variable involvement of the central and peripheral autonomic networks. The major pathologic hallmark of Parkinson's disease and dementia with Lewy bodies is Lewy bodies and Lewy neurites; of multiple system atrophy, oligodendroglial cytoplasmic inclusions; and of pure autonomic failure, peripheral neuronal cytoplasmic inclusions...
January 3, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29297193/advanced-and-traditional-electrocardiographic-risk-factors-in-pulmonary-arterial-hypertension-the-significance-of-ventricular-late-potentials
#19
Barbara Uznańska-Loch, Kamil Wikło, Ewa Trzos, Karina Wierzbowska-Drabik, Łukasz Chrzanowski, Jarosław Damian Kasprzak, Małgorzata Kurpesa
BACKGROUND: Whether non-invasive electrocardiographic parameters may be of similar relevance in pulmonary arterial hypertension (PAH) as in left ventricular heart failure (LVHF) remains unclear. AIM: To examine a profile of electrocardiographic parameters in PAH and to determine their prognostic significance. Comparison of profile in patients with pulmonary hypertension secondary to left ventricular dysfunction was planned to put PAH group results into context. METHODS: We included 41 patients with type 1...
January 3, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29290040/mechanism-of-neuroprotection-against-experimental-spinal-cord-injury-by-riluzole-or-methylprednisolone
#20
Cynthia Sámano, Andrea Nistri
Any spinal cord injury carries the potential for persistent disability affecting motor, sensory and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of deleterious reactions developing in the spinal areas immediately around the primary lesion. Thus, early timing of pharmacological neuroprotection should be one major strategy whose impact may be first studied with preclinical models. Using a simple in vitro model of the rat spinal cord it is possible to mimic pathological processes like excitotoxicity that damages neurons because of excessive glutamate receptor activation due to injury, or hypoxic/dysmetabolic insult that preferentially affects glia following vascular dysfunction...
December 30, 2017: Neurochemical Research
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