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Rosacea treatment

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https://www.readbyqxmd.com/read/29771307/assessment-of-rosacea-symptom-severity-by-genome-wide-association-study-and-expression-analysis-highlights-immuno-inflammatory-and-skin-pigmentation-genes
#1
Jennifer L Aponte, Mathias N Chiano, Laura M Yerges-Armstrong, David A Hinds, Chao Tian, Akansha Gupta, Cong Guo, Dana J Fraser, Johannes M Freudenberg, Deepak K Rajpal, Margaret G Ehm, Dawn M Waterworth
Rosacea is a common, chronic skin disease of variable severity with limited treatment options. The cause of rosacea is unknown, but it is believed to be due to a combination of hereditary and environmental factors. Little is known about the genetics of the disease. We performed a genome-wide association study (GWAS) of rosacea symptom severity with data from 73,265 research participants of European ancestry from the 23andMe customer base. Seven loci had variants associated with rosacea at the genome-wide significance level (p≤5 × 10-8)...
May 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29750171/phylogeny-of-maleae-rosaceae-based-on-multiple-chloroplast-regions-implications-to-genera-circumscription
#2
Jiahui Sun, Shuo Shi, Jinlu Li, Jing Yu, Ling Wang, Xueying Yang, Ling Guo, Shiliang Zhou
Maleae consists of economically and ecologically important plants. However, there are considerable disputes on generic circumscription due to the lack of a reliable phylogeny at generic level. In this study, molecular phylogeny of 35 generally accepted genera in Maleae is established using 15 chloroplast regions. Gillenia is the most basal clade of Maleae, followed by Kageneckia + Lindleya , Vauquelinia , and a typical radiation clade, the core Maleae, suggesting that the proposal of four subtribes is reasonable...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29746429/dual-frequency-ultrasound-as-a-new-treatment-modality-for-refractory-rosacea-a-retrospective-study
#3
Jun Yeong Park, Min Kyun Ahn, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim
BACKGROUND: Dual-frequency ultrasound (DFU) has emerged as a new treatment modality for improving inflammatory skin disorders. Although there have been few pilot studies, there are a limited number of studies that investigated efficacy of DFU on refractory rosacea. OBJECTIVE: This study investigated the effect of DFU on patients with refractory rosacea. MATERIALS AND METHODS: The authors retrospectively analyzed medical records of 42 patients with refractory rosacea (erythematotelangiectatic rosacea [ETR], n = 26; papulopustular rosacea [PPR], n = 14, mixed, n = 2)...
May 9, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29732490/chemical-constituents-from-sanguisorba-officinalis-l-and-their-inhibitory-effects-on-lps-stimulated-pro-inflammatory-cytokine-production-in-bone-marrow-derived-dendritic-cells
#4
Xiang Dong Su, Irshad Ali, Madeeha Arooj, Young Sang Koh, Seo Young Yang, Young Ho Kim
Sanguisorba officinalis L. (Rosaceae) is a perennial herbaceous plant and its roots have been used as an important astringent medicine in Eastern Asian countries over many thousand years. In this phytochemical research, 23 compounds (1-23) were isolated from the roots of S. officinalis. Their chemical structures were identified by extensive spectroscopic methods, including 1D and 2D NMR experiments. The anti-inflammatory effects of extracts and isolated compounds were investigated by measuring the production of pro-inflammatory cytokine IL-12 p40, IL-6 and TNF-α in LPS-stimulated bone marrow-derived dendritic cell...
May 7, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29729107/which-acne-treatment-has-the-best-influence-on-health-related-quality-of-life-literature-review-by-the-european-academy-of-dermatology-and-venereology-task-force-on-quality-of-life-and-patient-oriented-outcomes
#5
REVIEW
P V Chernyshov, L Tomas-Aragones, L Manolache, A Svensson, S E Marron, A W M Evers, V Bettoli, G B Jemec, J C Szepietowski
According to results of a recent literature search performed by the European Academy of Dermatology and Venereology (EADV) Task Forces (TF) on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS) most of publications where health-related (HR) QoL of acne patients was studied were clinical trials. Members of the EADV TF on QoL and PO decided to detect which acne treatment has the best influence on HRQoL of acne patients. A new literature search was organized to find publications on acne treatment where the HRQoL of patients was assessed as an outcome measure...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29714807/-time-to-limit-the-use-of-antibiotics-in-rosacea
#6
Håkan Mobacken, Mats Berg, Eva Angesjö, Kari Dunér, Margareta Svensson, Ingrid Synnerstad
Rosacea is a chronic inflammatory disease with facial erythema and papulopustules. It is common in middle-aged/elderly persons and often affects self-perception and social well-being. It is generally classified into four subtypes. Improved understanding of pathophysiology has resulted in novel treatment approaches, but routine management in health care usually follows old trails. Most patients are managed in primary care. Greater attention to the reduced skin barrier, avoidance of exacerbating factors, better topicals and encouragement to topical maintenance treatment should reduce the use of oral tetracyclines...
April 24, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29706982/an-apetala2-homolog-rcap2-regulates-the-number-of-rose-petals-derived-from-stamens-and-response-to-temperature-fluctuations
#7
Yu Han, Aoying Tang, Huihua Wan, Tengxun Zhang, Tangren Cheng, Jia Wang, Weiru Yang, Huitang Pan, Qixiang Zhang
Rosa chinensis , which is a famous traditional flower in China, is a major ornamental plant worldwide. Long-term cultivation and breeding have resulted in considerable changes in the number of rose petals, while most wild Rosaceae plants have only one whorl consisting of five petals. The petals of double flowers reportedly originate from stamens, but the underlying molecular mechanism has not been fully characterized. In this study, we observed that the number of petals of R. chinensis 'Old Blush' flowers increased and decreased in response to low- and high-temperature treatments, respectively, similar to previous reports...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29699769/papulopustular-rosacea-response-to-treatment-with-oral-azithromycin
#8
M Lova Navarro, P Sánchez-Pedreño Guillen, A M Victoria Martínez, T Martínez Menchón, R Corbalán Vélez, J Frías Iniesta
INTRODUCTION: Oral tetracyclines and topical antibiotics have been used to treat papulopustular rosacea (PPR) for years, but it is not uncommon to find patients who do not respond to this standard treatment. In such refractory cases, oral azithromycin has proven to be an effective option. MATERIAL AND METHOD: We conducted a prospective pilot study of 16 patients with PPR who were treated with oral azithromycin after a lack of response to oral doxycycline and metronidazole gel...
April 23, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29693177/the-therapeutic-effect-of-artesunate-on-rosacea-through-the-inhibition-of-the-jak-stat-signaling-pathway
#9
Ting Li, Qingwen Zeng, Xingming Chen, Guojiang Wang, Haiqing Zhang, Aihua Yu, Hairui Wang, Yang Hu
Acne rosacea is a type of chronic dermatosis with the characteristics of erubescence, angiotelectasis and pustule formation. However, current treatment methods are limited due to the side effects. Artesunate demonstrated a promising therapeutic efficacy with a high safety margin. HaCaT cells were treated with antibacterial peptide LL‑37 to simulate rosacea caused by Demodex folliculorum (D. folliculorum) infection. Cell Counting kit 8 and flow cytometry assays were performed to measure cellular proliferation, apoptosis, the stage of the cell cycle and reactive oxygen species generation in order to determine the level of cell damage...
April 16, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29676194/dose-duration-and-cost-opportunities-to-improve-use-of-long-term-oral-antibiotics-for-people-with-rosacea
#10
Joanne S Rill, Hadar Lev-Tov, Guodong Liu, Joslyn S Kirby
BACKGROUND: Systemic antibiotics are often used to treat rosacea and tetracyclines are the most common antibiotic prescribed; however, there is ambiguity among clinical guideline suggestions. Importantly, there is an increasing call to all clinicians to curtail antibiotic use. OBJECTIVE: Investigate the utilization and cost of long-term oral antibiotic use for the treatment of rosacea, including ocular rosacea. METHODS: This was a retrospective cohort study of MarketScan® Commercial Claims and Encounters database, from January 1, 2005 through December 31, 2014...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29676186/it-takes-one-to-know-one-exploring-patient-dialogue-on-rosacea-web-based-platforms-and-their-potential-for-significant-harm
#11
Laura H Riddoch
BACKGROUND: Rosacea is a non-curable skin condition, leading patients to turn self-management options from web based platforms. Self-management can be dangerous possibly under-reported. AIM: To discover the extent of online material and determine the potential for harm influenced by rosacea internet sources. MATERIALS AND METHODS: Material analysed included search engines, apps, YouTube, forums and Facebook groups. As Facebook and forums were most active, they became the core focus...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29642830/-a-new-strategy-for-enhancing-acanthamoebicidal-activity-with-synthesis-of-nanoflower-of-laurocerausus-officinalis-roemer-cherry-laurel-fruit-extracts
#12
Ayşe Baldemir, Ülkü Karaman, Sadi Yusufbeyoğlu, Ayşe Eken, Nilay Ildız, Selen İlgün, Cemil Çolak, Gamze Kaçmaz, İsmail Öçsoy, Soner Çankaya
Pathogenic Acanthamoeba species often cause infection known as Acanthamoeba keratitis among people who use contact lenses. It is a type of infection that can result in corneal ulceration, visual loss or even blindness, if not treated. There are various therapeutic options available in the treatment of Acanthamoeba infections but they are usually tough treatments with limited efficacy. For instance, hydrogen peroxide (H2 O2 ) is a commonly used contact lens disinfectant which is effective against Acanthamoeba but it is toxic to the cornea...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29551906/psychosocial-aspects-of-rosacea-with-a-focus-on-anxiety-and-depression
#13
REVIEW
Monika Heisig, Adam Reich
Background: Rosacea is a common, chronic skin condition characterized by facial redness and inflammatory lesions. The disease can lead to social stigmatization and may significantly reduce the quality of life of patients. Psychosocial impact of rosacea can be severe and debilitating; however, it is still underestimated. Objective: This paper provides a literature review focused on depression and anxiety in patients with rosacea. Conclusion: Rosacea patients have an increased risk of developing depression and anxiety and tend to avoid social situations...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29544355/ivermectin-1-cd5024-for-the-treatment-of-rosacea
#14
Dev R Sahni, Steven R Feldman, Sarah L Taylor
Rosacea is a chronic and recurrent disease with a variety of cutaneous manifestations. The disorder is a centrofacial inflammatory dermatosis with significant financial, physical and psychological impacts. There are a number of topical, oral and systemic treatments available. Yet, treatment for rosacea remains difficult. The multifactorial nature of the disease combined with an incomplete understanding of the pathophysiology is challenging for providers and patients. Areas covered: This article provides an in-depth review of rosacea treatment and emerging use of ivermectin 1% cream for papulopustular rosacea based on multiple clinical trials...
April 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29537449/phase-2-randomized-dose-ranging-study-of-oxymetazoline-cream-for-treatment-of-persistent-facial-erythema-associated-with-rosacea
#15
Janet DuBois, Jeffrey S Dover, Terry M Jones, Robert A Weiss, David R Berk, Gurpreet Ahluwalia
BACKGROUND: Rosacea is a chronic dermatologic condition with limited treatment options. OBJECTIVE: This phase 2 study evaluated the optimal oxymetazoline dosing regimen in patients with moderate to severe persistent facial erythema of rosacea. METHODS: Patients were randomly assigned to oxymetazoline cream, 0.5%, 1.0%, or 1.5%, or vehicle, administered once daily (QD) or twice daily (BID) for 28 consecutive days. The primary efficacy endpoint was the proportion of patients with ≥2-grade improvement from baseline on the Clinician Erythema Assessment (CEA) and the Subject Self-Assessment of erythema (SSA-1) on day 28...
March 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29537447/pivotal-trial-of-the-efficacy-and-safety-of-oxymetazoline-cream-1-0-for-the-treatment-of-persistent-facial-erythema-associated-with-rosacea-findings-from-the-second-reveal-trial
#16
Leslie Baumann, David J Goldberg, Linda Stein Gold, Emil A Tanghetti, Edward Lain, Joely Kaufman, Emily Weng, David R Berk, Gurpreet Ahluwalia
Rosacea is a chronic dermatologic condition with limited treatment options, particularly for persistent erythema. This pivotal phase 3 study evaluated oxymetazoline, an a1A-adrenoceptor agonist, for the treatment of moderate to severe persistent erythema of rosacea. Eligible patients were randomly assigned 1:1 to receive oxymetazoline cream 1.0% or vehicle applied topically to the face once daily for 29 days. The primary efficacy outcome was ≥2-grade improvement from baseline on both Clinician Erythema Assessment (CEA) and Subject Self-Assessment for rosacea facial redness (SSA) (composite success) at 3, 6, 9, and 12 hours postdose on day 29...
March 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29515751/topical-ivermectin-data-supporting-dual-modes-of-action-in-rosacea
#17
REVIEW
James Q Del Rosso
Until recently, the potential modes of action of topical ivermectin in rosacea have been speculated but not studied. Short-term studies (12 week), long-term studies (up to 52 weeks), and case report series have now been completed, and topical ivermectin (IVM), formulated as a 1% cream that is applied once daily, has been shown to be effective, well-tolerated, and safe for the treatment of rosacea. This article reviews outcomes from studies that support dual modes of action, including both anti-inflammatory and anti-parasitic effects...
September 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29507456/an-update-on-the-treatment-of-rosacea
#18
REVIEW
Alexis Lara Rivero, Margot Whitfeld
No abstract text is available yet for this article.
February 2018: Australian Prescriber
https://www.readbyqxmd.com/read/29499800/patient-costs-associated-with-rosacea
#19
REVIEW
Jackson G Turbeville, Hossein Alinia, Sara Moradi Tuchayi, Naeim Bahrami, Leah A Cardwell, Olabola Awosika, Irma Richardson, Karen E Huang, Steven R Feldman
The recalcitrance of rosacea to many treatment options may prompt patients to spend exorbitant amounts of money on unsubstantiated treatment regimens in an effort to achieve relief. The authors examine the relationship between disease severity and treatment cost across several demographic and socioeconomic strata. Familiarization of evidence-based clinical recommendations and consensus guidelines may equip physicians to educate patients about the most efficacious and cost-effective treatment options to assist patients in making cost-conscious decisions in the management of their rosacea...
April 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29499798/medical-management-of-facial-redness-in-rosacea
#20
REVIEW
Abigail Cline, Sean P McGregor, Steven R Feldman
Persistent centrofacial erythema is a predominant component of rosacea. The authors review the topical and systemic treatments for rosacea-related erythema and flushing to aid in treatment decision making in clinical practice. Databases were searched for literature pertaining to treatment options for erythema related to rosacea. The paucity of large-scale clinical trials in patients with the erythematotelangiectatic rosacea subtype makes it difficult to draw firm conclusions regarding treatment. Although certain topical and oral treatments appear to have modest benefit in reducing erythema, there is a need for high-quality, well-designed, and rigorously reported studies for the treatments for rosacea...
April 2018: Dermatologic Clinics
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