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https://www.readbyqxmd.com/read/28802484/electrosurgery-for-the-treatment-of-moderate-or-severe-rhinophyma
#1
L F González, H Herrera, A Motta
Rhinophyma, a rare and progressive disfiguring condition, is thought to be the final stage of rosacea. Several surgical treatments are available, including dermabrasion, cryosurgery, scalpel excision, electrosurgery, and carbon dioxide laser. The last 2 techniques are the most effective for the management of rhinophyma. We describe a series of cases of moderate or severe rhinophyma treated with high-frequency electrosurgery in the dermatology department of Hospital Simón Bolivar and in private clinics in Bogota, Colombia, between 2012 and 2016...
August 9, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28794954/cationic-supramolecular-hydrogels-for-overcoming-the-skin-barrier-in-drug-delivery
#2
David Limón, Claire Jiménez-Newman, Mafalda Rodrigues, Arántzazu González-Campo, David B Amabilino, Ana C Calpena, Lluïsa Pérez-García
A cationic bis-imidazolium-based amphiphile was used to form thermoreversible nanostructured supramolecular hydrogels incorporating neutral and cationic drugs for the topical treatment of rosacea. The concentration of the gelator and the type and concentration of the drug incorporated were found to be factors that strongly influenced the gelling temperature, gel-formation period, and overall stability and morphology. The incorporation of brimonidine tartrate resulted in the formation of the most homogeneous material of the three drugs explored, whereas the incorporation of betamethasone resulted in a gel with a completely different morphology comprising linked particles...
August 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28790801/intense-pulsed-light-for-evaporative-dry-eye-disease
#3
REVIEW
Steven J Dell
There is a clear association between dry eye disease (DED) and skin inflammatory diseases occurring in close proximity to the eyelids, such as facial skin rosacea. Intense pulsed light (IPL) is widely accepted as a treatment for skin rosacea. A number of recent studies demonstrated that, in patients suffering from meibomian gland dysfunction (MGD), IPL therapy also reduces signs and symptoms of DED. Despite these encouraging results, in the context of DED and MGD, the mechanisms of action of IPL are not well understood...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28782548/treatment-of-ocular-rosacea
#4
REVIEW
Edward J Wladis, Alejandro P Adam
While rosacea is a common entity with significant cosmetic, socioeconomic, and vision-threatening impacts, this disorder remains incurable. Furthermore, until quite recently, many of the therapeutic options for rosacea had not been assessed through rigorous clinical testing with meaningful outcome measures. Nonetheless, new medical and surgical interventions that have been validated in well-designed trials hold the promise of treating rosacea more effectively. Furthermore, recent enhancements in our understanding of the cellular and molecular biology offer highly translational insights that will hopefully lead to the development of new treatment options for rosacea...
August 3, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28776782/%C3%A2-%C3%A2-malignant%C3%A2-%C3%A2-rosacea-as-a-sign-of-systemic-marginal-zone-lymphoma
#5
A Lamoureux, Béatrice Vergier, Gladys Fidelin-Ferrati, Pierrick Hans, Noel Milpied, Marie Beylot-Barry
Rosacea is a common facial dermatosis for which differential diagnoses have to be considered in the case of atypical features or treatment failure. We report 3 cases of systemic marginal zone lymphomas (MZL), with skin involvement simulating rosacea. A 76-year-old man presented a rhinophyma for one year (Fig 1). This article is protected by copyright. All rights reserved.
August 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28769789/knowledge-of-medicinal-plants-for-children-diseases-in-the-environs-of-district-bannu-khyber-pakhtoonkhwa-kpk
#6
Shabnam Shaheen, Safdar Abbas, Javid Hussain, Fazal Mabood, Muhammad Umair, Maroof Ali, Mushtaq Ahmad, Muhammad Zafar, Umar Farooq, Ajmal Khan
Medicinal plants are important treasures for the treatment of different types of diseases. Current study provides significant ethnopharmacological information, both qualitative and quantitative on medical plants related to children disorders from district Bannu, Khyber Pakhtunkhwa (KPK) province of Pakistan. The information gathered was quantitatively analyzed using informant consensus factor, relative frequency of citation and use value method to establish a baseline data for more comprehensive investigations of bioactive compounds of indigenous medicinal plants specifically related to children disorders...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28748731/long-term-management-of-distinct-facial-flushing-and-persistent-erythema-of-rosacea-by-treatment-with-carvedilol
#7
Katharina Pietschke, Martin Schaller
BACKGROUND: The treatment of persistent erythema and flushing episodes in patients with rosacea remains a clinical challenge. A possible therapeutic option could be given be the use of antihypertensive drugs. OBJECTIVES: We therefore evaluated the effect of the non-selective β-blocker carvedilol in five caucasian patients. METHODS: In a monocentric, retrospective case study the patients were treated with carvedilol titrated up to 12.5 mg twice a day over at least six months...
July 27, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28740369/spotlight-on-brimonidine-topical-gel-0-33-for-facial-erythema-of-rosacea-safety-efficacy-and-patient-acceptability
#8
REVIEW
Michael S Anderson, Anish Nadkarni, Leah A Cardwell, Hossein Alinia, Steven R Feldman
BACKGROUND: Brimonidine tartrate is a highly selective alpha 2 agonist that induces direct vasoconstriction of small arteries and veins, thereby reducing vasodilation and edema. OBJECTIVE: To review the current literature regarding the safety, efficacy, and patient acceptability of brimonidine 0.33% gel. METHODS: A PubMed search was performed using the terms brimonidine 0.33% gel, rosacea, safety, efficacy, and acceptability. Peer-reviewed clinical trials and case reports from 2012 to 2016 were screened for inclusion of safety, efficacy, and/or patient acceptability data...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28736585/late-onset-asymptomatic-pancreatic-neuroendocrine-tumor-a-case-report-on-the-phenotypic-expansion-for-men1
#9
Charu Kaiwar, Sarah K Macklin, Jennifer M Gass, Jessica Jackson, Eric W Klee, Stephanie L Hines, John A Stauffer, Paldeep S Atwal
BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a hereditary cancer syndrome associated with several endocrine as well as non-endocrine tumors and is caused by mutations in the MEN1 gene. Primary hyperparathyroidism affects the majority of MEN1 individuals by age 50 years. Additionally, MEN1 mutations trigger familial isolated hyperparathyroidism. We describe a seemingly unaffected 76-year-old female who presented to our Genetics Clinic with a family history of primary hyperparathyroidism and the identification of a pathogenic MEN1 variant...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/28728857/-rosacea-new-data-for-better-care
#10
B Cribier
In the last 10 years, numerous studies have been published that throw new light on rosacea, in all areas of the disease. This overview summarises all the key developments, based on the indexed bibliography appearing in Medline between 2007 and 2017. Recent epidemiological data show that the prevalence of the disease is doubtless greater than estimated hitherto (more than 10% of adults in some countries) and that we should not overlook rosacea in subjects with skin phototypes V or VI, a condition that exists on all continents...
July 17, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28696955/pediatric-blepharokeratoconjunctivitis-is-there-a-right-treatment
#11
Sepideh T Rousta
PURPOSE OF REVIEW: This article highlights the importance of recognizing blepharokeratoconjunctivitis (BKC) in children and reviews the clinical characteristics and current therapeutic modalities. RECENT FINDINGS: The mainstay of BKC treatment remains controlling the meibomian gland inflammation and treating cobormid conditions. BKC can occur in the setting of ocular rosacea and Demodex infestation. Small studies have shown treatment benefits of topical cyclosporine A as well as oral azithromycin in pediatric BKC...
July 10, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28686779/efficacy-and-tolerability-of-a-cosmetic-skin-care-product-with-trans-4-t-butylcyclohexanol-and-licochalcone-a-in-subjects-with-sensitive-skin-prone-to-redness-and-rosacea
#12
Zorica Jovanovic, Nariman Angabini, Sonja Ehlen, Zrinka Bukvic Mokos, Milica Subotic, Gitta Neufang
<p>BACKGROUND: Sensitive skin and rosacea are skin conditions, which may affect the quality of life of the patients considerably. In vitro and in vivo data indicated that the combination of trans-t-butylcyclohexanol and licochalcone A is an effective combination for alleviating the increased sensitivity of rosacea subtype I.</p> <p>OBJECTIVE: Objective of this open dermocosmetic study was to investigate the efficacy and tolerability of a skin care product containing the anti-inflammatory licochalcone A and the TRPV1 antagonist trans-t-butylcyclohexanol in subjects with sensitive skin prone to redness and rosacea...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28686772/a-pilot-double-blind-placebo-controlled-study-to-assess-the-efficacy-and-safety-of-incobotulinumtoxina-injections-in-the-treatment-of-rosacea
#13
Steven H Dayan, Nazanin Ashourian, Katherine Cho
<p>BACKGROUND: Rosacea has a variable presentation. Whereas the pathophysiology may differ, erythema, and flushing are the most consistent findings in all patients.</p> <p>OBJECTIVE: To evaluate the safety and efficacy of incobotulinumtoxinA in reducing the severity of rosacea symptoms.</p> <p>METHODS: Nine subjects with erythematotelangiectactic or papulopustular rosacea were randomized in 2 groups. Subjects in Group 1 (n=4) received up to a total of 20 U of incobotulinumtoxinA in the affected area (across both cheeks)...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28679382/ethnopharmacological-survey-of-home-remedies-used-for-treatment-of-hair-and-scalp-and-their-methods-of-preparation-in-the-west-bank-palestine
#14
Abdel Naser Zaid, Nidal Amin Jaradat, Ahmad Mustafa Eid, Hamzeh Al Zabadi, Abdulsalam Alkaiyat, Saja Adam Darwish
BACKGROUND: Natural products have many uses and purposes, including those linked to pharmaceutics and cosmetics. The aim of this study was to investigate the use of natural remedies for the treatment of hair and scalp disorders in the West Bank, Palestine. METHODS: An ethnopharmacological survey of herbal remedies and other natural products used in cosmetics and cosmeceuticals was carried out in the West Bank, Palestine. A questionnaire was distributed to 267 herbalists, traditional healers, hairdressers and rural dwellers...
July 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28667759/experiences-of-rosacea-and-its-treatment-an-interpretative-phenomenological-analysis
#15
S A Johnston, M Krasuska, A Millings, A C Lavda, A R Thompson
BACKGROUND: Whilst rosacea is a chronic skin condition, the condition can often have a large psychosocial impact on the individual. There is therefore a need to understand the experience of living with rosacea from the patient perspective. OBJECTIVES: To examine the experience of living with rosacea and the experience of seeking and receiving treatment. METHODS: Nine participants took part in semi-structured interviews, which were analysed using interpretative phenomenological analysis...
July 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28656562/diagnosis-and-treatment-of-rosacea-fulminans-a-comprehensive-review
#16
REVIEW
Rabina K Walsh, Alyson A Endicott, Kanade Shinkai
Rosacea fulminans is a rare inflammatory condition of the central face marked by the abrupt onset of erythematous coalescing papules, pustules, nodules, and draining sinuses. Due to infrequent reporting in the literature, the pathophysiology, classification, and nomenclature of this condition remain controversial. This comprehensive review evaluated a total of 135 cases of rosacea fulminans for clinical and histopathologic features and reported treatment strategies. Patients were 91% female with an average age of onset of 31...
June 27, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28652793/evaluation-of-a-novel-very-high-sun-protection-factor-moisturizer-in-adults-with-rosacea-prone-sensitive-skin
#17
Mathieu Grivet-Seyve, Francine Santoro, Nadège Lachmann
BACKGROUND/OBJECTIVE: Rosacea-prone sensitive skin requires high sun-protection factor (SPF) moisturizers. This study evaluated Daylong Extreme SPF 50+ lotion, a novel cream containing five ultraviolet filters, two emollients, and three skin conditioners. SUBJECTS AND METHODS: This was an open-label, single-center study. On day 1, before treatment, subjects answered a questionnaire on their skin conditions and sunscreen habits, and both subjects and dermatologist evaluated skin status...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28650692/the-role-of-polyphenols-in-rosacea-treatment-a-systematic-review
#18
Suzana Saric, Ashley K Clark, Raja K Sivamani, Peter A Lio, Hadar A Lev-Tov
OBJECTIVES: Various treatment options are available for the management of rosacea symptoms such as facial erythema, telangiectasia, papules and pustules, burning, stinging, and itching. Botanical therapies are commonly used to treat the symptoms. The objective of this review is to evaluate the use of polyphenols in rosacea treatment. DESIGN: PubMed, Embase, Biosis, Web of Knowledge, and Scopus databases were systematically searched for clinical studies evaluating polyphenols in the management of rosacea...
June 26, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28647601/benzaldehyde-dehydrogenase-driven-phytoalexin-biosynthesis-in-elicitor-treated-pyrus-pyrifolia-cell-cultures
#19
Shashank Sagar Saini, Deepa Teotia, Mariam Gaid, Anirudh Thakur, Ludger Beerhues, Debabrata Sircar
Pyrus pyrifolia (Asian pear) cell cultures respond to yeast extract (YE) treatment by accumulating benzoate-derived biphenyl phytoalexins, namely, noraucuparin and aucuparin. Biphenyl phytoalexins are defense-marker metabolites of the sub-tribe Malinae of the family Rosaceae. The substrates for biphenyl biosynthesis are benzoyl-CoA and malonyl-CoA, which combine in the presence of biphenyl synthase (BIS) to produce 3,5-dihydroxybiphneyl. In the non-β-oxidative pathway, benzoyl-CoA is directly derived from benzoic acid in a reaction catalyzed by benzoate-CoA ligase (BZL)...
June 13, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28626508/rate-of-adverse-events-and-healthcare-costs-associated-with-the-topical-treatment-of-rosacea
#20
Todd Williamson, Rajesh Kamalakar, Augustina Ogbonnaya, Erin A Zagadailov, Michael Eaddy, Charlie Kreilick
BACKGROUND: Rosacea is a condition more common in women than in men, and in people aged ≥30 years than in younger patients. Adverse events associated with the use of topical medications for rosacea may lead to a lack of treatment adherence. Previous studies have reported low treatment adherence rates among patients with rosacea. OBJECTIVE: To describe the rate of treatment discontinuation resulting from adverse events and the associated healthcare costs among patients with rosacea who are receiving a topical medication...
May 2017: American Health & Drug Benefits
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