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Rosacea treatment

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https://www.readbyqxmd.com/read/28932125/an-empirically-generated-responder-definition-for-rosacea-treatment
#1
Gerald Staedtler, Kaweh Shakery, Jan Endrikat, Richard Nkulikiyinka, Christoph Gerlinger
OBJECTIVE: The aim of this study was to empirically generate a responder definition for the treatment of papulopustular rosacea. METHODS: A total of 8 multicenter clinical studies on patients with papulopustular facial rosacea were analyzed. All patients were treated with azelaic acid and/or comparator treatments. The severity of rosacea was described by the Investigator Global Assessment (IGA) and the number of lesions. Patients with the IGA score of "clear/minimal" were considered as responders, and those staying in the range of IGA "mild to severe" as nonresponders...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28917186/compounds-isolated-from-eriobotrya-deflexa-leaves-protect-against-ultraviolet-radiation-b-induced-photoaging-in-human-fibroblasts
#2
Chung-Yu Huang, Yi-Tzu Lin, Hsiang-Chun Kuo, Wen-Fei Chiou, Mei-Hsien Lee
Ultraviolet (UV) irradiation leads to skin photoaging because of the upregulation of matrix metalloproteinase (MMP)-1 and downregulation of type I collagen and tissue inhibitor of metalloproteinase (TIMP)-1. Eriobotrya deflexa (Hemsl.) Nakai (Rosaceae) is a flowering plant endemic to Taiwan, and its leaves have been used as an expectorant and in antitussive folk remedy. Our previous studies have demonstrated that an E. deflexa leaf extract functions as a free radical scavenger. The current evaluated the antiphotoaging effect of partitioned fractions and specific compounds from the leaves of E...
September 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28915286/treatment-of-rosacea-with-concomitant-use-of-topical-ivermectin-1-cream-and-brimonidine-0-33-gel-a-randomized-vehicle-controlled-study
#3
Linda Stein Gold, Kim Papp, Charles Lynde, Edward Lain, Melinda Gooderham, Sandra Johnson, Nabil Kerrouche
BACKGROUND: There is currently a lack of data on the simultaneous treatment of different features of rosacea. Individually, ivermectin 1% (IVM) cream and brimonidine 0.33% (BR) gel have demonstrated efficacy on inflammatory lesions and persistent erythema, respectively. OBJECTIVE: To evaluate the efficacy, safety, patient satisfaction, and optimal timing of administration of IVM associated with BR (IVM+BR) versus their vehicles in rosacea (investigator global assessment [IGA] ≥3)...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28902026/chemical-peels-indications-and-special-considerations-for-the-male-patient
#4
Jeave Reserva, Amanda Champlain, Seaver L Soon, Rebecca Tung
BACKGROUND: Chemical peels are a mainstay of aesthetic medicine and an increasingly popular cosmetic procedure performed in men. OBJECTIVE: To review the indications for chemical peels with an emphasis on performing this procedure in male patients. MATERIALS AND METHODS: Review of the English PubMed/MEDLINE literature and specialty texts in cosmetic dermatology, oculoplastic, and facial aesthetic surgery regarding sex-specific use of chemical peels in men...
September 4, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28898474/quality-of-life-measurement-in-acne-position-paper-of-the-european-academy-of-dermatology-and-venereology-eadv-task-forces-on-quality-of-life-and-patient-oriented-outcomes-qol-and-po-and-acne-rosacea-and-hidradenitis-suppurativa-arhs
#5
REVIEW
P V Chernyshov, C C Zouboulis, L Tomas-Aragones, G B Jemec, L Manolache, T Tzellos, F Sampogna, A W M Evers, C Dessinioti, S E Marron, V Bettoli, O D van Cranenburgh, A Svensson, A I Liakou, F Poot, J C Szepietowski, Salek, A Y Finlay
Acne causes profound negative psychological and social effects on the quality of life (QoL) of patients. The European Dermatology Forum S3-Guideline for the Treatment of Acne recommended adopting a QoL measure as an integral part of acne management. Because of constantly growing interest in health-related QoL assessment in acne and because of the high impact of acne on patients' lives, the European Academy of Dermatology and Venereology Task Force on QoL and Patient Oriented Outcomes and the Task Force on Acne, Rosacea and Hidradenitis Suppurativa have documented the QoL instruments that have been used in acne patients, with information on validation, purposes of their usage, description of common limitations and mistakes in their usage and overall recommendations...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28895387/chaenomeles-%C3%A2-health-promoting-benefits
#6
Katarzyna Watychowicz, Katarzyna Janda, Karolina Jakubczyk, Jolanta Wolska
Chaenomeles is a genus of deciduous spiny in the family of Rosaceae (Pomoideae subfamily). For centuries, the plant was used for a treatment of anemia, rheumatism, gout and cardiovascular diseases. The chemical composition studies of Chaenomeles showed the presence of many biologically active compounds, such as: phenolic compounds, organic acids, terpenoids, alcohols, ketones or aldehydes. Fruit of Chaenomeles has the largest applying potential due to extensive use of medicinal and high concentration of vitamin C...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28889348/treatment-of-erythemato-telangiectatic-rosacea-with-brimonidine-alone-or-combined-with-vascular-laser-based-on-preliminary-instrumental-evaluation-of-the-vascular-component
#7
Giuseppe Micali, Federica Dall'Oglio, Anna Elisa Verzì, Ivano Luppino, Karishma Bhatt, Francesco Lacarrubba
The purpose of this study is to evaluate the outcome of a series of patients with erythematotelangiectatic rosacea (ETR) affected by persistent erythema and varying degree of telangiectasias being treated with brimonidine alone or combined with a vascular laser based on the type of vascular components preliminarily evaluated by clinical and instrumental observation. Ten patients affected by ETR were enrolled in a pilot, open study. Instrumental evaluation included erythema-directed digital photography by VISIA-CR™ system and X10 dermoscopy...
September 9, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28886453/patterns-of-low-temperature-induced-accumulation-of-dehydrins-in-rosaceae-crops-evidence-for-post-translational-modification-in-apple
#8
Perttu Haimi, Jurgita Vinskienė, Inga Stepulaitienė, Danas Baniulis, Gražina Stanienė, Jūratė Bronė Šikšnianienė, Rytis Rugienius
Important crop plants of Rosaceae family are often damaged during winter due to the lack of acclimation and cold hardiness. One of the cellular responses of plants to cold stress is the accumulation of dehydrin proteins. We studied the expression of dehydrins in several Rosaceae species during low temperature treatment in vitro. Microshoots of Pyrus communis, Malus×domestica, Fragaria vesca, Fragaria×ananassa, Prunus cerasus and Prunus avium cultivars were grown in low temperature conditions. Genotype -specific accumulation of dehydrins was detected by immunoblot analysis of the extracted proteins...
August 31, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28873109/lack-of-significant-anti-inflammatory-activity-with-clindamycin-in-the-treatment-of-rosacea-results-of-2-randomized-vehicle-controlled-trials
#9
Philippe Martel, Michael Jarratt, Jonathan Weiss, Isabelle Carlavan
Rosacea is a chronic inflammatory skin disease of the face. The objective of the studies described here was to evaluate the efficacy of clindamycin in the treatment of rosacea. Two multicenter, randomized, vehicle-controlled, phase 2 studies were conducted in participants with moderate to severe rosacea. Study A was a 12-week dose-comparison, 5-arm, parallel group comparison of clindamycin cream 1% or vehicle once or twice daily and clindamycin cream 0.3% once daily. Study B was a 2-arm comparison of twice daily clindamycin gel 1% versus vehicle gel...
July 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28873101/rosacea-treatment-schema-an-update
#10
Lorraine L Rosamilia
No abstract text is available yet for this article.
July 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28846817/the-usefulness-of-investigating-the-possible-underlying-conditions-in-rosacea
#11
G Ciccarese, A Parodi, A Rebora, F Drago
The paper entitled "Rosacea and demodicidosis with gain of function mutation in STAT1″ by Second et al.(1) is of indubitable interest and prompted us to make some observations. The Authors described a patient with cutaneous and ocular rosacea that they related to demodicidosis since oral ivermectin improved the cutaneous lesions(1) . However, the Authors did not demonstrate by skin scraping nor by standardized skin surface biopsy (SSSB) an excessive number of Demodex folliculorum (DF) mites in the pilosebaceous units to justify an oral antiparasitic treatment as a drug of first choice(1) ...
August 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28837365/oxymetazoline-hydrochloride-cream-for-facial-erythema-associated-with-rosacea
#12
Nupur U Patel, Shweta Shukla, Jessica Zaki, Steven R Feldman
Rosacea is a chronic skin condition characterized by transient and persistent erythema of the central face. The symptom of persistent erythema can be particularly frustrating for both patients and physicians as it is difficult to treat. Areas covered: Current treatment options for the treatment of rosacea include metronidazole, azelaic acid, sodium sulfacetamide-sulfur, and brimonidine. Until recently, brimonidine gel was the only option approved specifically for the treatment of facial erythema. However, oxymetazoline hydrochloride 1% cream is a newly FDA approved topical medication for adult rosacea patients...
August 24, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28832233/bioactivity-guided-isolation-and-identification-of-anti-adipogenic-compounds-from-sanguisorba-officinalis
#13
Sun Hyuk Im, Zhiqiang Wang, Soon Sung Lim, Ok-Hwan Lee, Il-Jun Kang
CONTEXT: Sanguisorba officinalis Linne (Rosaceae) is a medicinal plant used traditionally for the treatment of inflammatory and metabolic diseases in Korea, China, and Japan. In our previous study, a 50% ethanol extract inhibited fat accumulation in 3T3-L1 adipocytes. OBJECTIVE: This study investigates bioassay-guided fractionation, isolation, and identification of anti-adipogenic bioactive compounds in S. officinalis. MATERIALS AND METHODS: The bioassay-guided fractionation was conducted using effective differentiation of 3T3-L1 cells into adipocytes (with 50 μg/mL test material for 8 days) to isolate the inhibitory compounds from ethyl acetate fraction of S...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28831422/laser-treatment-of-medical-skin-disease-in-women
#14
REVIEW
C LaRosa, A Chiaravalloti, S Jinna, W Berger, J Finch
Laser treatment is a relatively new and increasingly popular modality for the treatment of many dermatologic conditions. A number of conditions that predominantly occur in women and that have a paucity of effective treatments include rosacea, connective tissue disease, melasma, nevus of Ota, lichen sclerosus (LS), notalgia paresthetica and macular amyloidosis, and syringomas. Laser therapy is an important option for the treatment of patients with these conditions. This article will review the body of literature that exists for the laser treatment of women with these medical conditions...
September 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28802484/electrosurgery-for-the-treatment-of-moderate-or-severe-rhinophyma
#15
L F González, H Herrera, A Motta
Rhinophyma, a rare and progressive disfiguring condition, is thought to be the final stage of rosacea. Several surgical treatments are available, including dermabrasion, cryosurgery, scalpel excision, electrosurgery, and carbon dioxide laser. The last 2 techniques are the most effective for the management of rhinophyma. We describe a series of cases of moderate or severe rhinophyma treated with high-frequency electrosurgery in the dermatology department of Hospital Simón Bolivar and in private clinics in Bogota, Colombia, between 2012 and 2016...
August 9, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28794954/cationic-supramolecular-hydrogels-for-overcoming-the-skin-barrier-in-drug-delivery
#16
David Limón, Claire Jiménez-Newman, Mafalda Rodrigues, Arántzazu González-Campo, David B Amabilino, Ana C Calpena, Lluïsa Pérez-García
A cationic bis-imidazolium-based amphiphile was used to form thermoreversible nanostructured supramolecular hydrogels incorporating neutral and cationic drugs for the topical treatment of rosacea. The concentration of the gelator and the type and concentration of the drug incorporated were found to be factors that strongly influenced the gelling temperature, gel-formation period, and overall stability and morphology. The incorporation of brimonidine tartrate resulted in the formation of the most homogeneous material of the three drugs explored, whereas the incorporation of betamethasone resulted in a gel with a completely different morphology comprising linked particles...
August 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28790801/intense-pulsed-light-for-evaporative-dry-eye-disease
#17
REVIEW
Steven J Dell
There is a clear association between dry eye disease (DED) and skin inflammatory diseases occurring in close proximity to the eyelids, such as facial skin rosacea. Intense pulsed light (IPL) is widely accepted as a treatment for skin rosacea. A number of recent studies demonstrated that, in patients suffering from meibomian gland dysfunction (MGD), IPL therapy also reduces signs and symptoms of DED. Despite these encouraging results, in the context of DED and MGD, the mechanisms of action of IPL are not well understood...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28782548/treatment-of-ocular-rosacea
#18
REVIEW
Edward J Wladis, Alejandro P Adam
While rosacea is a common entity with significant cosmetic, socioeconomic, and vision-threatening impacts, this disorder remains incurable. Furthermore, until quite recently, many of the therapeutic options for rosacea had not been assessed through rigorous clinical testing with meaningful outcome measures. Nonetheless, new medical and surgical interventions that have been validated in well-designed trials hold the promise of treating rosacea more effectively. Furthermore, recent enhancements in our understanding of the cellular and molecular biology offer highly translational insights that will hopefully lead to the development of new treatment options for rosacea...
August 3, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28776782/%C3%A2-malignant-%C3%A2-rosacea-as-a-sign-of-systemic-marginal-zone-lymphoma
#19
LETTER
A Lamoureux, B Vergier, G Fidelin-Ferrati, P Hans, N Milpied, M Beylot-Barry
No abstract text is available yet for this article.
August 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28769789/knowledge-of-medicinal-plants-for-children-diseases-in-the-environs-of-district-bannu-khyber-pakhtoonkhwa-kpk
#20
Shabnam Shaheen, Safdar Abbas, Javid Hussain, Fazal Mabood, Muhammad Umair, Maroof Ali, Mushtaq Ahmad, Muhammad Zafar, Umar Farooq, Ajmal Khan
Medicinal plants are important treasures for the treatment of different types of diseases. Current study provides significant ethnopharmacological information, both qualitative and quantitative on medical plants related to children disorders from district Bannu, Khyber Pakhtunkhwa (KPK) province of Pakistan. The information gathered was quantitatively analyzed using informant consensus factor, relative frequency of citation and use value method to establish a baseline data for more comprehensive investigations of bioactive compounds of indigenous medicinal plants specifically related to children disorders...
2017: Frontiers in Pharmacology
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