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Rosacea treatment

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https://www.readbyqxmd.com/read/28543746/rosacea-is-associated-with-helicobacter-pylori-a-systematic-review-and-meta-analysis
#1
REVIEW
Astrid-Helene R Jørgensen, Alexander Egeberg, Robin Gideonsson, Leonard B Weinstock, Erik P Thyssen, Jacob P Thyssen
BACKGROUND: Rosacea is a common skin disease characterized by facial erythema, telangiectasia, papules, and pustules. Helicobacter pylori infection has been suggested to play a role in the etiopathogenesis of rosacea. OBJECTIVE: Systematically review and meta-analyse the relationship between rosacea and infection with Helicobacter pylori . METHODS: A literature search was performed using PubMed, EMBASE, and Web of Science. Data extraction and analyses were performed on descriptive data...
May 23, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28541877/erythromelalgia-involving-the-face
#2
Rachel R Gilmore, Danielle S Applebaum, Jessica L Parsons, Sylvia Hsu
Erythromelalgia is a rare disorder characterized by burning pain, erythema, and increased temperature typically involving the distal extremities. Although it can progress to involve the face, erythromelalgia presenting only on the face is particularly rare. This disorder is often misdiagnosed when it presents on the extremities and is even more likely to be misdiagnosed when presenting only on the face, delaying appropriate treatment and causing considerable frustration for the patient. We report a case of a 26-year-old woman with erythromelalgia that involved only the face for a number of years and was treated unsuccessfully as rosacea, seborrheic dermatitis, and contact dermatitis...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28524050/cutaneous-adverse-effects-during-ipilimumab-treatment-for-metastatic-melanoma-a-prospective-study
#3
Emi Dika, Giulia Maria Ravaioli, Pier Alessandro Fanti, Bianca Maria Piraccini, Martina Lambertini, Marco Adriano Chessa, Carlotta Baraldi, Simone Ribero, Ardizzoni Andrea, Barbara Melotti, Annalisa Patrizi
Ipilimumab is an immunomodulatory antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which is administered to patients with advanced melanoma, with a proven positive effect on overall survival. The cutaneous adverse effects (AEs) of ipilimumab are relatively frequent, although described as usually mild and rarely life threatening. To describe a three-year experience of a single institute in detecting and managing cutaneous AEs. A cohort of patients (n = 41) treated with ipilimumab (3 mg/kg/three weeks) for metastatic melanoma, from 2013 to 2016, was investigated for adverse cutaneous events...
May 19, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28492949/the-role-of-skin-care-in-optimizing-treatment-of-acne-and-rosacea
#4
C Zip
A triad approach to the treatment of acne and rosacea has been recommended. This integrated management approach includes patient education, selection of therapeutic agents, and initiation of an appropriate skin care regime. Proper skin care in patients undergoing treatment of both acne and rosacea includes use of products formulated for sensitive skin that cleanse, moisturize and photoprotect the skin. Both acne and rosacea are associated with epidermal barrier dysfunction, which can be mitigated by suitable skin care practices...
May 2017: Skin Therapy Letter
https://www.readbyqxmd.com/read/28486718/the-role-of-skin-care-in-optimizing-treatment-of-acne-and-rosacea
#5
C Zup
A triad approach to the treatment of acne and rosacea has been recommended. This integrated management approach includes patient education, selection of therapeutic agents, and initiation of an appropriate skin care regime. Proper skin care in patients undergoing treatment of both acne and rosacea includes use of products formulated for sensitive skin that cleanse, moisturize and photoprotect the skin. Both acne and rosacea are associated with epidermal barrier dysfunction, which can be mitigated by suitable skin care practices...
May 2017: Skin Therapy Letter
https://www.readbyqxmd.com/read/28475520/mucocutaneous-hyperpigmentation-in-a-patient-with-a-history-of-both-minocycline-and-silver-ingestion
#6
Angel Fernandez-Flores, Thao Nguyen, David S Cassarino
Minocycline is a derivative of tetracycline. It has been widely used in dermatology for the treatment of acne and rosacea. One of its adverse effects is pigmentation of various body tissues. Clinically, 3 main distinct types of hyperpigmentation by minocycline have been distinguished: type I, with blue-gray to black pigment on the face in areas of scarring or inflammation; type II, with blue-gray pigment on normal skin of the legs, forearms and on the shins; and type III, with a diffuse muddy-brown discoloration in areas of sun exposure...
April 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28472572/rosacea
#7
Danit Maor, Alvin H Chong
BACKGROUND: Rosacea is a chronic and common cutaneous condition characterised by symptoms of facial flushing and a broad spectrum of clinical signs. The clinical presentation for rosacea is varied, and there are four primary subtypes, which may overlap - erythrotelangiectatic, inflammatory, phymatous and ocular. It is important to recognise the different subtypes because of the differences in therapy. OBJECTIVE: The objective of this article is to provide evidence-based clinical updates to clinicians, specifically general practitioners (GPs), to assist with their everyday practice, and effective assessment and treatment of rosacea...
2017: Australian Family Physician
https://www.readbyqxmd.com/read/28452093/effects-of-helicobacter-pylori-treatment-on-rosacea-a-single-arm-clinical-trial-study
#8
Parviz Saleh, Mohammad Naghavi-Behzad, Hamdieh Herizchi, Fatemeh Mokhtari, Mohammad Mirza-Aghazadeh-Attari, Reza Piri
Rosacea is a chronic dermatological disease. Helicobacter pylori has been discussed as one of its causative factors. In this clinical trial study, we attempted to evaluate the effect of H. pylori standard eradication protocol on the rosacea clinical course. In this single-arm clinical trial, patients ascertained to have H. pylori infection based on serological studies were assessed to examine existence of rosacea. Patients with concurrent rosacea and H. pylori infection were included in the study and underwent standard H...
April 28, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28445195/protective-effect-of-botulinum-toxin-type-a-against-atopic-dermatitis-like-skin-lesions-in-nc-nga-mice
#9
Sang Bum Han, Hyeree Kim, Sang Hyun Cho, Jin Ho Chung, Hei Sung Kim
BACKGROUND: Botulinum neurotoxin (BTX) A possesses various biological activities, including anti-inflammatory and antipruritic actions. Human and animal studies have shown that BTX is effective in treating histamine-induced itch, lichen simplex chronicus, psoriasis, rosacea, allergic rhinitis, and scar prevention. However, its effect on atopic dermatitis (AD) has not been studied yet. OBJECTIVE: To examine the effect of BTX on AD using a mouse model. The primary outcome was skin thickness and transepidermal water loss (TEWL), and the secondary outcome was the alteration in skin severity scores, histological, and laboratory test results...
April 24, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28413391/minocycline-induced-hyperpigmentation-in-a-patient-treated-with-erlotinib-for-non-small-cell-lung-adenocarcinoma
#10
Ann T Bell, John W Roman, Max L Gratrix, Christina E Brzezniak
INTRODUCTION: While epidermal growth factor receptor (EGFR) inhibitors have improved progression-free survival in patients with non-small cell lung cancer (NSCLC), one of the most common adverse effects is papulopustular skin eruption, which is frequently severe enough to be treated with oral minocycline or doxycycline. CASE: We present a case of an 87-year-old man who developed a severe papulopustular skin eruption secondary to erlotinib therapy for NSCLC. Control of the eruption with 100 mg of minocycline twice daily for 8 months eventually led to blue-gray skin hyperpigmentation...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28410769/-granulomatous-periocular-eruption
#11
M Moncourier, P Pralong, N Pinel, I Templier, M-T Leccia
BACKGROUND: Herein, we report a case of atypical periorificial dermatitis in a patient that had been receiving treatment for some time for atopic dermatitis. The specific feature of this rash was its periocular predominance with no perioral involvement, its clinical aspect and its histological picture evocative of sarcoidosis. PATIENTS AND METHODS: A 33-year-old man was being treated for a atopic dermatitis limited to the face and poorly responsive to dermal corticosteroids...
April 11, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28405739/dermatological-comorbidity-in-psoriasis-results-from-a-large-scale-cohort-of-employees
#12
N Zander, I Schäfer, M Radtke, A Jacobi, H Heigel, M Augustin
The field of dermatological comorbidity in psoriasis is only passively explored with contradictory results. Objective of this study was to further investigate the complex field of psoriasis and associated skin diseases by identifying skin comorbidity patterns in an extensive cohort of employees in Germany. Retrospective analysis of data deriving from occupational skin cancer screenings was conducted. From 2001 to 2014 German employees between 16 and 70 years from different branches underwent single whole-body screenings by trained dermatologists in their companies...
April 12, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28400287/anti-inflammatory-and-vasoconstrictive-properties-of-potentilla-erecta-a-traditional-medicinal-plant-from-the-northern-hemisphere
#13
Ute Wölfle, Julia Hoffmann, Birgit Haarhaus, Venugopal Rao Mittapalli, Christoph M Schempp
ETHNOPHARMACOLOGICAL RELEVANCE: Potentilla erecta (L.) Raeusch is a medicinal plant of the Northern hemisphere belonging to the plant family of roses (Rosaceae). It has traditionally been used to treat inflammatory disorders of the skin and mucous membranes as well as chronic diarrhea. AIM OF THE STUDY: In the present study we analyzed the anti-inflammatory and vasoconstrictive effect of a Potentilla erecta extract (PE) and questioned if PE is similar effective as mild corticosteroids...
April 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28388720/new-uses-of-abobotulinumtoxina-in-aesthetics
#14
Joel Schlessinger, Erin Gilbert, Joel L Cohen, Joely Kaufman
BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance...
May 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28387417/microscale-coiling-in-bis-imidazolium-supramolecular-hydrogel-fibres-induced-by-the-release-of-a-cationic-serine-protease-inhibitor
#15
David Limón, Claire Jiménez-Newman, Ana C Calpena, Arántzazu González-Campo, David B Amabilino, Lluïsa Pérez-García
Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration.
April 7, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28349651/dermasence-refining-gel-modulates-pathogenetic-factors-of-rosacea-in-vitro
#16
C Borelli, B Becker, S Thude, B Fehrenbacher, D Isermann
BACKGROUND: Over the counter cosmetics sold for local treatment of slight to moderate rosacea often state the claim of actively modulating rosacea pathogenesis. Factors involved in the pathogenesis of this common yet complex skin disorder include kallikrein-related peptidase 5 (KLK5), LL-37, as well as protease-activated receptor 2 (PAR2) and vascular endothelial growth factor (VEGF). OBJECTIVE: The objective was to prove the modulating effect of the cosmetic skin care agent Dermasence Refining Gel (DRG) on factors involved in rosacea pathogenesis...
March 27, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28341953/giant-rhinophyma-a-rare-case-of-total-nasal-obstruction-and-restitutio-ad-integrum
#17
Andreas Wolter, Till Scholz, Jutta Liebau
Rhinophyma is considered the end stage in the development of rosacea, accompanied by hypertrophy of the sebaceous glands, which causes an enlargement of the nose. It is an uncommon condition that often results in both functional and cosmetic impairment. A large variety of surgical and nonsurgical treatments have been published to treat it. Closure is usually obtained by wound granulating in by secondary intention, skin grafting or local flaps. Rarely these lesions can attain a giant size and pose a challenge in surgical treatment...
March 24, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28329606/clinical-applications-of-topical-ivermectin-in-dermatology
#18
Omid Zargari, Nessa Aghazadeh, Fatemeh Moeineddin
Ivermectin (IVM) is a broad-spectrum anti-parasitic drug with significant anti-inflammatory properties. The emergence of treatment resistance to lindane, permethrin, and possibly malathion complicates the global strategy for management of common parasitic skin diseases such as scabies and head lice. In this regard. IVM has been safely and effectively used in the treatment of these common human infestations. In addition, IVM may be useful in inflammatory cutaneous disorders such as papulopustular rosacea where demodex may play a role in pathogenesis...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329576/5-fluorouracil-induced-exacerbation-of-rosacea
#19
Ellen S Haddock, Philip R Cohen
Background Topical 5-fluorouracil (5-FU) is an antineoplastic antimetabolite used for the treatment of actinic keratosis.Purpose A 66-year-old man with erythematotelangiectatic rosacea and biopsy-confirmed actinic keratoses who experienced a rosacea exacerbation after initiating topical 5-FU treatment of his actinic keratoses is described and this adverse event associated with 5-FU is reviewed.Materials and methods Using PubMed.gov the following terms were searched and relevant citations were assessed: rosacea and 5-fluorouracil...
November 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28300926/rosacea-fulminans-unusual-clinical-presentation-of-rosacea
#20
Jessica Castiel Coutinho, Danielle Cristine Westphal, Laís Cruz Lobato, Antônio Pedro Mendes Schettini, Mônica Santos
Rosacea fulminans or pyoderma faciale is a rare cutaneous disorder that usually affects women usually between the ages of 15-46. The disease is characterized by sudden onset of papules, pustules, cysts, and painful coalescing nodules with red-cyanotic centrofacial erythema. Although its etiology remains unknown, hormonal, immunological, and vascular factors have been reported. Early diagnosis and prompt treatment should minimize unsightly scars. We report a case of a 33-year-old female patient treated with traditional doses of doxycycline, with improvement of the lesions and regression of the condition in two months...
September 2016: Anais Brasileiros de Dermatologia
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