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https://www.readbyqxmd.com/read/27893539/comparative-efficacy-of-radiofrequency-and-pulsed-dye-laser-in-the-treatment-of-rosacea
#1
Sue-Jeong Kim, Young Lee, Young-Joon Seo, Jeung-Hoon Lee, Myung Im
BACKGROUND: Laser and light-based therapies have been used successfully in the treatment of rosacea; however, evidence is lacking regarding the efficacy of radiofrequency (RF). OBJECTIVE: This study evaluated the efficacy of RF in the treatment of rosacea compared with pulsed dye laser (PDL). METHODS: Thirty patients with rosacea (erythematotelangiectatic rosacea [ETR], n = 20; papulopustular rosacea [PPR], n = 10) were enrolled in a randomized, controlled, split-face study...
November 23, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27891741/combination-treatment-of-propranolol-minocycline-and-tranexamic-acid-for-effective-control-of-rosacea
#2
Hyun Jung Kwon, Joon Hyuk Suh, Eun Jung Ko, Beom Joon Kim
No abstract text is available yet for this article.
November 27, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27879178/-minocycline-induced-hyperpigmentation-not-uncommon-but-nonetheless-important-to-recognise
#3
P J G M Voets, D Blommaert, R R M C Keijsers, H A C Alkemade
BACKGROUND: Minocycline, a broad-spectrum antibiotic from the group of tetracyclins, is frequently prescribed for acne vulgaris and rosacea. Hyperpigmentation is a relatively common side effect of this drug and can lead to multiple unsightly skin lesions, which are not always reversible. It can take a long period, from a few months to several years, before the lesions have completely vanished. CASE DESCRIPTION: A 24-year-old male was seen in our outpatient clinic because of slowly progressive pigmented lesions on his shins...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27878597/the-sweet-cherry-prunus-avium-flowering-locus-t-gene-is-expressed-during-floral-bud-determination-and-can-promote-flowering-in-a-winter-annual-arabidopsis-accession
#4
Antonia Yarur, Esteban Soto, Gabriel León, Andrea Miyasaka Almeida
FT gene is expressed in leaves and buds and is involved in floral meristem determination and bud development in sweet cherry. In woody fruit perennial trees, floral determination, dormancy and bloom, depends on perception of different environmental and endogenous cues which converge to a systemic signaling gene known as FLOWERING LOCUS T (FT). In long-day flowering plants, FT is expressed in the leaves on long days. The protein travels through the phloem to the shoot apical meristem, where it induces flower determination...
December 2016: Plant Reproduction
https://www.readbyqxmd.com/read/27874885/patient-reported-outcomes-of-azelaic-acid-foam-15-for-patients-with-papulopustular-rosacea-secondary-efficacy-results-from-a-randomized-controlled-double-blind-phase-3-trial
#5
Stephen Tyring, James A Solomon, Gerald Staedtler, Jason P Lott, Richard Nkulikiyinka, Kaweh Shakery
Patient-reported treatment outcomes are important for evaluating the impact of drug therapies on patient experience. A randomized, double-blind, vehicle-controlled, parallel-group, multicenter, phase 3 study was conducted in 961 participants to assess patient perception of efficacy, utility, and effect on quality of life (QOL) of an azelaic acid (AzA) 15% foam formulation for the treatment of papulopustular rosacea (PPR). Secondary end points included patient-reported global assessment of treatment response, global assessment of tolerability, and opinion on cosmetic acceptability and practicability of product use...
October 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27869379/rosacea-management-update-on-general-measures-and-topical-treatment-options
#6
M Schaller, H Schöfer, B Homey, M Hofmann, U Gieler, P Lehmann, T A Luger, T Ruzicka, M Steinhoff
Although there is presently no cure for rosacea, there are several recommended treatment options available to control many of the symptoms and to prevent them from getting worse. In addition to self-help measures like avoidance of trigger factors and proper skin care, rosacea management should include topical medications as one of the first-line choices for patients with erythematous and mild to severe papulopustular rosacea. Since mixed forms of characteristic rosacea symptoms are more common, medical treatment must be symptom-tailored for each individual case and will often involve a combination therapy...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27869377/physical-modalities-for-the-treatment-of-rosacea
#7
Maja A Hofmann, Percy Lehmann
Rosacea is characterised by a wide variety of vascular changes. Apart from telangiectasia and erythema, often so-called flushing occurs. These vascular abnormalities can be targeted with specific light and laser devices. In addition to KTP laser, pulsed dye laser (PDL) and Nd:YAG laser, also intense pulsed light devices (IPLs) are used. The described therapeutic effects include the reduction of vascular abnormalities and even improvement of papulopustular changes. While the KTP laser shows very good results in telangiectasia, the dye laser and IPL devices are used preferably in erythema...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27869374/state-of-the-art-systemic-rosacea-management
#8
M Schaller, H Schöfer, B Homey, U Gieler, P Lehmann, T A Luger, T Ruzicka, M Steinhoff
Based on numerous trials, oral tetracyclines and most commonly their second-generation derivative doxycycline have become the main pillar in systemic rosacea treatment. However, the only preparation that has been approved so far in this setting is 40 mg doxycycline in an anti-inflammatory dosage and with a modified release formulation. With the introduction of this once-daily, non-antibiotic dosing of doxycycline, oral therapy is more commonly prescribed as first-line treatment in moderate to severe papulopustular rosacea...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27861741/rosacea-treatment-update-recommendations-from-the-global-rosacea-consensus-rosco-panel
#9
M Schaller, L Almeida, A Bewley, B Cribier, N Dlova, G Kautz, M Mannis, H Oon, M Rajagopalan, M Steinhoff, D Thiboutot, P Troielli, G Webster, Y Wu, E van Zuuren, J Tan
BACKGROUND: Rosacea is currently treated according to subtypes. As this does not adequately address the patient spectrum of clinical presentation (phenotypes), it has implications for patient management. The ROSacea COnsensus (ROSCO) panel was established to address this issue. OBJECTIVES: To incorporate current best treatment evidence with clinical experience from an international expert panel and establish consensus to improve outcomes for patients with rosacea...
November 12, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27843919/rosacea-management
#10
REVIEW
Manal Abokwidir, Steven R Feldman
BACKGROUND: Rosacea is a chronic inflammatory skin condition associated with four distinct subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular. PURPOSE: To review the different kinds of management for all subtypes. METHODS: We divided rosacea management into three main categories: patient education, skin care, and pharmacological/procedural interventions. RESULTS: Flushing is better prevented rather than treated, by avoiding specific triggers, decreasing transepidermal water loss by moisturizers, and blocking ultraviolet light...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27800249/clinical-findings-follow-up-and-treatment-results-in-patients-with-ocular-rosacea
#11
İlkay Kılıç Müftüoğlu, Yonca Aydın Akova
OBJECTIVES: To report the clinical features, treatment options and complications in patients with ocular rosacea. MATERIALS AND METHODS: The records of 48 eyes of 24 patients with ocular rosacea were retrospectively reviewed. Patients' ocular signs and symptoms were scored between 1 and 4 points according to disease severity; tear film break-up time (BUT) and Schirmer's test results were recorded before and after the treatment. Preservative-free artificial tears, topical antibiotic eye drops/ointments, short-term topical corticosteroids, topical 0...
January 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27797396/domino-doxycycline-40mg-vs-minocycline-100mg-in-the-treatment-of-rosacea-a-randomised-single-blinded-non-inferiority-trial-comparing-efficacy-and-safety
#12
M M D van der Linden, A R van Ratingen, D C van Rappard, S A Nieuwenburg, Ph I Spuls
BACKGROUND: There is lack of evidence for minocycline in the treatment of rosacea. OBJECTIVES: To compare the efficacy and safety of doxycycline 40mg versus minocycline 100mg in papulopustular rosacea. METHODS: In this randomised single centre, 1:1 allocation, assessor blinded, non-inferiority trial, patients with a mild to severe papulopustular rosacea, were randomly allocated to either oral doxycycline 40mg or minocycline 100mg for a 16-week period with 12 weeks of follow up...
October 31, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27769934/polyphenolic-glycoconjugates-from-medical-plants-of-rosaceae-asteraceae-family-protect-human-lymphocytes-against-%C3%AE-radiation-induced-damage
#13
Magdalena Szejk, Tomasz Poplawski, Joanna Sarnik, Izabela Pawlaczyk-Graja, Franciszek Czechowski, Alicja Klaudia Olejnik, Roman Gancarz, Halina Malgorzata Zbikowska
Radioprotective effects of the water-soluble polyphenolic glycoconjugates, isolated from flowers of Sanguisorba officinalis L.(SO) and Erigeron canadensis L.(EC), and from leaves of Fragaria vesca L. (FV) and Rubus plicatus Whe. Et N. E. (RP), against γ-radiation-induced toxicity in human peripheral blood lymphocytes were investigated. Cell treatment with glycoconjugates (1, 5 and 25μg/mL) prior exposure to 10/15Gy radiation resulted in concentration-dependent reduction of DNA damage including oxidative DNA lesions (comet assay), substantial inhibition of lipid peroxidation (TBARS) and restoration of superoxide dismutase and S-glutathione transferase activities...
October 18, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27762482/treatment-of-erythematotelangiectatic-rosacea-with-the-fractionation-of-high-fluence-long-pulsed-595-nm-pulsed-dye-laser
#14
Jin Ok Baek, Hoon Hur, Ha Ryeong Ryu, Jeong Soo Kim, Kyung Real Lee, Yu Ri Kim, Kwang Ho Choi
Various lasers have been used for the treatment of erythematotelangiectatic rosacea (ETR) that does not respond to systemic or topical therapy. The pulsed dye lasers (PDLs) are an effective option for ETR, and the purpuragenic fluence proved to be superior until now. Given that purpura and subsequent possible postinflammatory hyperpigmentation (PIH) are occasionally unbearable in some patients, and several studies using the low nonpurpuragenic fluence were reported. To deliver the sufficient high fluence of a PDL without generating purpura, we designed the fractionation of high fluence using five passes and longer pulse duration (6 milliseconds) of a PDL in succession...
October 20, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27746641/prospective-comparison-of-dual-wavelength-long-pulsed-755-nm-alexandrite-1-064-nm-neodymium-yttrium-aluminum-garnet-laser-versus-585-nm-pulsed-dye-laser-treatment-for-rosacea
#15
Hyun-Min Seo, Jung-In Kim, Han-Saem Kim, Young-Jun Choi, Won-Serk Kim
BACKGROUND: Rosacea treatments including oral/topical medications and laser therapy are numerous but unsatisfactory. OBJECTIVE: To compare the effectiveness of the dual wavelength long-pulsed 755-nm alexandrite/1,064-nm neodymium: yttrium-aluminum-garnet laser (LPAN) with that of 585-nm pulsed dye laser (PDL) for rosacea. METHODS: This was a randomized, single-blinded, comparative study. Full face received four consecutive monthly treatments with LPAN or PDL, followed-up for 6 months after the last treatment...
October 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27721054/in-vitro-and-in-vivo-assessment-of-meadowsweet-filipendula-ulmaria-as-anti-inflammatory-agent
#16
Jelena Katanić, Tatjana Boroja, Vladimir Mihailović, Stefanie Nikles, San-Po Pan, Gvozden Rosić, Dragica Selaković, Jovana Joksimović, Slobodanka Mitrović, Rudolf Bauer
ETHNOPHARMACOLOGICAL RELEVANCE: Meadowsweet (Filipendula ulmaria (L.) Maxim, Rosaceae) has been traditionally used in most European countries for the treatment of inflammatory diseases due to its antipyretic, analgesic, astringent, and anti-rheumatic properties. However, there is little scientific evidence on F. ulmaria anti-inflammatory effects regarding its impact on cyclooxygenases enzymatic activity and in vivo assessment of anti-inflammatory potential. This study aims to reveal the anti-inflammatory activity of methanolic extracts from the aerial parts (FUA) and roots (FUR) of F...
October 6, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27689107/an-ethnobotanical-study-of-medicinal-plants-administered-for-the-treatment-of-hypertension
#17
Babak Baharvand-Ahmadi, Mahmoud Bahmani, Pegah Tajeddini, Mahmoud Rafieian-Kopaei, Nasrollah Naghdi
INTRODUCTION: The incidence of cardiovascular diseases (CVDs) is very high in human societies and their prevention and treatment are the most important priority in many countries. Hypertension makes an important contribution to the development of CVDs. OBJECTIVES: This study aimed to collect the ethno-medicinal knowledge of the traditional healers of Shiraz on medicinal plants used in the treatment of hypertension. MATERIALS AND METHODS: Ethno-medicinal data were collected from September 2012 to July 2013 through direct interview...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27683017/black-veins-a-case-of-minocycline-induced-pigmentation-post-sclerotherapy-and-a-review-of-literature
#18
Phoebe Star, Carolyn Choy, Kurosh Parsi
Minocycline-induced pigmentation (MIP) is an uncommon but well-described adverse effect of oral minocycline treatment. MIP is clinically and histopathologically distinct from post-sclerotherapy pigmentation. We report a case of a patient presenting with blackened skin overlying veins recently treated with endovenous laser and foam sclerotherapy. The patient was a 44-year-old male with systemic sclerosis who commenced minocycline for the treatment of rosacea 5 months prior. Histological examination of the discolored tissue and underlying vein revealed hemosiderin deposition in the dermis and pigmented macrophages within the sub-endothelial layer of the vein wall with a staining pattern consistent with MIP...
September 28, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27672409/improving-treatment-of-erythematotelangiectatic-rosacea-with-laser-and-or-topical-therapy-through-enhanced-discrimination-of-its-clinical-features
#19
REVIEW
Giuseppe Micali, Peter Arne Gerber, Francesco Lacarrubba, Gregor Schäfer
Rosacea is a chronic inflammatory disease that can present with a variety of cutaneous symptoms. Erythematotelangiectatic rosacea is a subtype characterized by flushing (transient erythema), persistent central facial erythema (background erythema), and telangiectasias. The severity of individual symptoms differs in each patient, which can complicate the selection of an appropriate treatment strategy. Evaluation of these specific symptoms has been greatly improved by the routine use of diagnostic tools such as (video) dermatoscopy...
July 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27649118/biphenyl-phytoalexin-in-sorbus-pohuashanensis-suspension-cell-induced-by-yeast-extract
#20
Liangyun Zhou, Jian Yang, Guang Yang, Chuanzhi Kang, Wenjuan Xiao, Chaogeng Lv, Sheng Wang, Jinfu Tang, Lanping Guo
Biphenyls are unique phytoalexins de novo synthesized in plants in response to pathogen attack. These compounds are found in Maloideae, a subfamily of the Rosaceae. The anti-microbial activities of biphenyls have been reported in a number of studies and they appear to represent an important defense strategy against pathogens common in the Maloideae, such as species in Malus, Pyrus, Sorbus, and Chaenomeles. Here, cell suspension cultures of Sorbus pohuashanensis were established to study biphenyl phytoalexins formation after yeast extract (YE) treatment...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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