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Post traumatic osteoarthritis

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https://www.readbyqxmd.com/read/29453795/inflammatory-and-degenerative-phases-resulting-from-anterior-cruciate-rupture-in-a-non-invasive-murine-model-of-post-traumatic-osteoarthritis
#1
Sophie Jane Gilbert, Cleo Selina Bonnet, Paulina Stadnik, Victor Colin Duance, Deborah JaneMason, Emma Jane Blain
Joint injury is the predominant risk factor for post-traumatic osteoarthritis development (PTOA). Several non-invasive mouse models mimicking human PTOA investigate molecular mechanisms of disease development; none have characterised the inflammatory response to this acute traumatic injury. Our aim was to characterise the early inflammatory phase and later degenerative component in our in vivo non-invasive murine model of PTOA induced by anterior cruciate ligament (ACL) rupture. Right knees of 12-week-old C57Bl6 mice were placed in flexion at a 30° offset position and subjected to a single compressive load (12N, 1...
February 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29409817/botulinum-toxin-treatment-of-pain-syndromes-an-evidence-based-review
#2
Yasaman Safarpour, Bahman Jabbari
This review evaluates the existing level of evidence for efficacy of BoNTs in different pain syndromes using the recommended efficacy criteria from the Assessment and Therapeutic Subcommittee of the American Academy of Neurology. There is a level A evidence (effective) for BoNT therapy in post-herpetic neuralgia, trigeminal neuralgia, and posttraumatic neuralgia. There is a level B evidence (probably effective) for diabetic neuropathy, plantar fasciitis, piriformis syndrome, pain associated with total knee arthroplasty, male pelvic pain syndrome, chronic low back pain, male pelvic pain, and neuropathic pain secondary to traumatic spinal cord injury...
January 31, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29393439/role-of-ift88-in-icariin%C3%A2-regulated-maintenance-of-the-chondrocyte-phenotype
#3
Wei Xiang, Jiaming Zhang, Rui Wang, Limei Wang, Shengjie Wang, Yingxing Wu, Yonghui Dong, Fengjing Guo, Tao Xu
Maintenance of the chondrocyte phenotype is crucial for cartilage repair during tissue engineering. Intraflagellar transport protein 88 (IFT88) is an essential component of primary cilia, shuttling signals along the axoneme. The hypothesis of the present study was that IFT88 could exert an important role in icariin‑regulated maintenance of the chondrocyte phenotype. To this end, the effects of icariin on proliferation and differentiation of the chondrogenic cell line, ATDC5, were explored. Icariin‑treated ATDC5 cells and primary chondrocytes expressed IFT88...
January 25, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29377313/sost-sclerostin-improves-post-traumatic-osteoarthritis-and-inhibits-mmp2-3-expression-after-injury
#4
Jiun C Chang, Blaine A Christiansen, Deepa K Murugesh, Aimy Sebastian, Nicholas R Hum, Nicole M Collette, Sarah Hatsell, Aris N Economides, Craig D Blanchette, Gabriela G Loots
Patients with anterior cruciate ligament (ACL) rupture are 2X as likely to develop post traumatic osteoarthritis (PTOA). Annually, there are ∼900,000 knee injuries in the US, which account for ∼12% of all OA cases. PTOA leads to reduced physical activity, deconditioning of the musculoskeletal system and in severe cases, requires joint replacement to restore function. Therefore, treatments that would prevent cartilage degradation post injury would provide attractive alternatives to surgery. Sclerostin (Sost), a Wnt antagonist and a potent negative regulator of bone formation has recently been implicated in regulating chondrocyte function in osteoarthritis (OA)...
January 26, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29323710/blocking-pi3k-akt-signaling-inhibits-bone-sclerosis-in-subchondral-bone-and-attenuates-post-traumatic-osteoarthritis
#5
Chuangxin Lin, Yan Shao, Chun Zeng, Chang Zhao, Hang Fang, Liping Wang, Jianying Pan, Liangliang Liu, Weizhong Qi, Xiaofeng Feng, Hong Qiu, Haiyang Zhang, Yuhui Chen, Hong Wang, Daozhang Cai, Cory J Xian
PI3K/AKT signaling is essential in regulating pathophysiology of osteoarthritis (OA). However, its potential modulatory role in early OA progression has not been investigated yet. Here, a mouse destabilization OA model in the tibia was used to investigate roles of PI3K/AKT signaling in the early subchondral bone changes and OA pathological process. We revealed a significant increase in PI3K/AKT signaling activation which was associated with aberrant bone formation in tibial subchondral bone following destabilizing the medial meniscus (DMM), which was effectively prevented by treatment with PI3K/AKT signaling inhibitor LY294002...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29315787/metabolomic-serum-profiling-after-acl-injury-in-rats-a-pilot-study-implicating-inflammation-and-immune-dysregulation-in-post-traumatic-osteoarthritis
#6
Tristan Maerz, Eric Sherman, Michael Newton, Ali Yilmaz, Praveen Kumar, Stewart F Graham, Kevin C Baker
ACL rupture is a major risk factor for post-traumatic osteoarthritis (PTOA) development. Little information exists on acute systemic metabolic indicators of disease development. 36 female Lewis rats were randomized to Control or noninvasive anterior cruciate ligament rupture (ACLR) and to three post-injury time points: 72 hours, 4 weeks, 10 weeks (n = 6). Serum was collected and analyzed by 1 H nuclear magnetic resonance (NMR) spectroscopy and combined direct injection and liquid chromatography (LC)-mass spectrometry (MS)/MS (DI-MS)...
January 8, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29313319/early-experience-with-a-tapered-titanium-porous-plasma-sprayed-stem-with-updated-design
#7
Antonio G Manocchio, Keith R Berend, Michael J Morris, Joanne B Adams, Adolph V Lombardi
INTRODUCTION: The Taperloc® Complete femoral stem (Zimmer Biomet, Warsaw, Indiana) builds on the widespread clinical success of the original Taperloc design used since 1982. Enhancements to the Complete design include a lowered caput-collum-diaphyseal (CCD) angle from 138° to 133° for improved offset, optimized neck taper with polished neck flats to increase range of motion, reduced distal geometry to improve proximal canal fill, and gradual off-loading that is the goal of tapered geometry...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29308969/social-cognitive-or-learning-theory-use-to-improve-self-efficacy-in-musculoskeletal-rehabilitation-a-systematic-review-and-meta-analysis
#8
Cameron Ghazi, John Nyland, Rumeal Whaley, Thomas Rogers, Jeff Wera, Cameron Henzman
OBJECTIVE: To review the rehabilitation research methodological quality and intervention effectiveness of studies that used social cognitive or learning theory principles to improve self-efficacy in patients with orthopedic or musculoskeletal conditions. DESIGN: A systematic literature review and meta-analysis of peer reviewed studies published in English was performed using the OVID and SPORTDiscus databases. Initial search terms were "social cognitive theory" or "social learning theory" combined with "rehabilitation"...
January 8, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29299491/evaluation-of-radiocapitellar-arthritis-in-patients-with-a-second-radiograph-at-least-2-years-after-nonoperative-treatment-of-an-isolated-radial-head-fracture
#9
Amir R Kachooei, David Ring
Background: To study if patients that have a second radiograph 2 or more years after nonoperative treatment of an isolated radial head fracture have radiocapitellar osteoarthritis (RC OA). Methods: We used the database of 3 academic hospitals in one health system from 1988 to 2013 to find patients with isolated radial head fractures (no associated ligament injury or fracture) that had a second elbow radiograph after more than 2 years from the initial injury. Of 887 patients with isolated radial head fractures, 54 (6%) had an accessible second radiograph for reasons of a second injury (57%), pain (30%), or follow-up visit (13%)...
November 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29284451/synovial-inflammation-plays-a-greater-role-in-post-traumatic-osteoarthritis-compared-to-idiopathic-osteoarthritis-in-the-hartley-guinea-pig-knee
#10
Nathan P Thomas, Wesley J Wu, Braden C Fleming, Fangyuan Wei, Qian Chen, Lei Wei
BACKGROUND: The objective of this study was to evaluate the extent of stromal cell-derived factor-1's (SDF-1) involvement in the pathogenesis of idiopathic versus post-traumatic OA by comparing differences in synovial membrane morphology, SDF-1 synovial fluid (SF) concentrations, and matrix metalloproteinase-13 (MMP-13) SF concentrations. METHODS: Thirty-six 3-month-old Hartley guinea pigs were obtained and divided into 6 groups. Upon sacrifice, India Ink staining was used to evaluate gross morphology, Safranin O/Fast green staining was used to assess cartilage damage, H/E staining was employed to visualize the synovium, and SF samples were obtained for biochemical analyses...
December 29, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29250157/myrtol-improves-post-traumatic-knee-osteoarthritis-by-regulation-of-reactive-oxygen-species-transforming-growth-factor-%C3%AE-1-and-apoptosis-in-a-mouse-model
#11
Liqun Duan, Wenzhi Zhang, Feng Zhang, Haiping Cai
The present study tested whether myrtol improves post-traumatic knee osteoarthritis (PTKO) by regulating the reactive oxygen species (ROS), transforming growth factor β1 (TGF-β1) and apoptosis in a mouse model. PTKO model mice were administered with 150, 300 or 450 mg/kg myrtol for 8 weeks. ELISA analysis was used to measure tumor necrosis factor-α, interleukin-6, malondialdehyde, superoxide dismutase, reactive oxygen species and TGF-β1 levels. Caspase-3 and Bax protein expressions were analyzed using western blot analysis...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29233667/knee-confidence-in-youth-and-young-adults-at-risk-of-post-traumatic-osteoarthritis-3-10-years-following-intra-articular-knee-injury
#12
A M Ezzat, J L Whittaker, C Toomey, P K Doyle-Baker, M Brussoni, C A Emery
OBJECTIVES: To examine differences in knee confidence between individuals with a history of youth sport-related knee injury and uninjured controls. DESIGN: Historical cohort study. METHODS: Participants include 100 individuals who sustained a youth sport-related intra-articular knee injury 3-10 years previously and 100 age-, sex- and sport-matched uninjured controls. Outcomes included: Knee confidence (Knee Osteoarthritis and Outcome Score); fat mass index (FMI; dual-energy X-ray absorptiometry); and weekly physical activity (modified Godin-Shephard Leisure Time Questionnaire)...
November 26, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29221903/discrete-element-analysis-is-a-valid-method-for-computing-joint-contact-stress-in-the-hip-before-and-after-acetabular-fracture
#13
Kevin C Townsend, Holly D Thomas-Aitken, M James Rudert, Andrew M Kern, Michael C Willey, Donald D Anderson, Jessica E Goetz
Evaluation of abnormalities in joint contact stress that develop after inaccurate reduction of an acetabular fracture may provide a potential means for predicting the risk of developing post-traumatic osteoarthritis. Discrete element analysis (DEA) is a computational technique for calculating intra-articular contact stress distributions in a fraction of the time required to obtain the same information using the more commonly employed finite element analysis technique. The goal of this work was to validate the accuracy of DEA-computed contact stress against physical measurements of contact stress made in cadaveric hips using Tekscan sensors...
November 16, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29212625/use-of-tricortical-iliac-crest-strut-autograft-in-comminuted-posterior-wall%C3%A2-acetabular-fractures-a-case-series
#14
Sandeep Gupta, Naveen Mittal, Jagandeep Singh Virk
PURPOSE: The results for fixation of comminuted posterior wall acetabular fractures are not very promising with reported complications in terms of osteoarthritis, nonunion and malunion which subsequently require conversion to total hip arthroplasty. The conversion to total hip arthroplasty is possible in patients over 50 years of age but not in younger patients. So this requires new methods for salvage of the native hip in young patients. METHODS: There were six patients in our series with highly comminuted posterior wall acetabular fractures where the fragments were excised and the gap filled with tricortical anterior iliac-crest strut autograft, fixed with screws and plate...
November 6, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29207792/clinical-evaluation-of-efficacy-and-performance-of-all-poly-tibial-freedom%C3%A2-total-knee-system-for-treating-osteoarthritis-patients-three-year-follow-up-study
#15
Avatar Singh, Kanwar Kulwinder Singh
Introduction: Advancement in technology in terms of design and building materials has made Total Knee Replacement (TKR) a highly effective, safe, and predictable orthopedic procedure. Aim: To review the clinical outcomes for efficacy and performance of Freedom Total Knee System for the management of Osteoarthritis (OA), at a minimum of three years follow up. Materials and Methods: For this retrospective, post-marketing study, clinical data of patients treated with Freedom Total Knee System was retrieved from the clinical records after approval from the Institutional Ethics Committee ...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205258/sustained-intra-cartilage-delivery-of-low-dose-dexamethasone-using-a-cationic-carrier-for-treatment-of-post-traumatic-osteoarthritis
#16
A G Bajpayee, R E De la Vega, M Scheu, N H Varady, I A Yannatos, L A Brown, Y Krishnan, T J Fitzsimons, P Bhattacharya, E H Frank, A J Grodzinsky, R M Porter
Disease-modifying osteoarthritis drugs (DMOADs) should reach their intra-tissue target sites at optimal doses for clinical efficacy. The dense, negatively charged matrix of cartilage poses a major hindrance to the transport of potential therapeutics. In this work, electrostatic interactions were utilised to overcome this challenge and enable higher uptake, full-thickness penetration and enhanced retention of dexamethasone (Dex) inside rabbit cartilage. This was accomplished by using the positively charged glycoprotein avidin as nanocarrier, conjugated to Dex by releasable linkers...
December 5, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/29202567/the-use-of-hyaluronic-acid-in-the-treatment-of-ankle-osteoarthritis-a-review-of-the-evidence
#17
R Papalia, E Albo, F Russo, A Tecame, G Torre, S Sterzi, F Bressi, V Denaro
Ankle osteoarthritis (OA) is a progressive degenerative joint disease that causes ankle pain and functional limitation especially during walking. It tends to involve younger people with high functional request and has often a post-traumatic origin. Symptoms control through conservative treatment is essential to procrastinate as long as possible the need for surgery. Although few data are present in literature about the use of local viscosupplementation in ankle OA, their potential use for ankle OA has been suggested...
December 27, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29191468/malunion-of-post-traumatic-thoracolumbar-fractures
#18
REVIEW
C Mazel, L Ajavon
Thoracolumbar malunion is the result of loss of correction, insufficient correction, or even no correction (both in the frontal and sagittal planes) of a thoracolumbar fracture. The main causes are incorrect assessment of the fracture's complexity (burst fracture), its potential progression to kyphosis, and associated disc or ligament damage. It can also be the result of a poorly conducted initial treatment. The types of malunion have changed over the years because of the introduction of vertebroplasty and kyphoplasty...
November 27, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29189731/differential-effects-of-superoxide-dismutase-mimetics-after-mechanical-overload-of-articular-cartilage
#19
Mitchell C Coleman, Marc J Brouillette, Nicholas S Andresen, Rebecca E Oberley-Deegan, James M Martin
Post-traumatic osteoarthritis can develop as a result of the initial mechanical impact causing the injury and also as a result of chronic changes in mechanical loading of the joint. Aberrant mechanical loading initiates excessive production of reactive oxygen species, oxidative damage, and stress that appears to damage mitochondria in the surviving chondrocytes. To probe the benefits of increasing superoxide removal with small molecular weight superoxide dismutase mimetics under severe loads, we applied both impact and overload injury scenarios to bovine osteochondral explants using characterized mechanical platforms with and without GC4403, MnTE-2-PyP, and MnTnBuOE-2-PyP...
November 30, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29177932/a-computational-algorithm-to-simulate-disorganization-of-collagen-network-in-injured-articular-cartilage
#20
Petri Tanska, Petro Julkunen, Rami K Korhonen
Cartilage defects are a known risk factor for osteoarthritis. Estimation of structural changes in these defects could help us to identify high risk defects and thus to identify patients that are susceptible for the onset and progression of osteoarthritis. Here, we present an algorithm combined with computational modeling to simulate the disorganization of collagen fibril network in injured cartilage. Several potential triggers for collagen disorganization were tested in the algorithm following the assumption that disorganization is dependent on the mechanical stimulus of the tissue...
November 24, 2017: Biomechanics and Modeling in Mechanobiology
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