keyword
MENU ▼
Read by QxMD icon Read
search

Post traumatic osteoarthritis

keyword
https://www.readbyqxmd.com/read/29691435/elf3-contributes-to-cartilage-degradation-in-vivo-in-a-surgical-model-of-post-traumatic-osteoarthritis
#1
Elisabeth B Wondimu, Kirsty L Culley, Justin Quinn, Jun Chang, Cecilia L Dragomir, Darren A Plumb, Mary B Goldring, Miguel Otero
The E-74 like factor 3 (ELF3) is a transcription factor induced by inflammatory factors in various cell types, including chondrocytes. ELF3 levels are elevated in human cartilage from patients with osteoarthritis (OA), and ELF3 contributes to the IL-1β-induced expression of genes encoding Mmp13, Nos2, and Ptgs2/Cox2 in chondrocytes in vitro. Here, we investigated the contribution of ELF3 to cartilage degradation in vivo, using a mouse model of OA. To this end, we generated mouse strains with cartilage-specific Elf3 knockout (Col2Cre:Elf3f/f ) and Comp-driven Tet-off-inducible Elf3 overexpression (TRE-Elf3:Comp-tTA)...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678623/differences-in-subchondral-bone-plate-and-cartilage-thickness-between-women-with-anterior-cruciate-ligament-reconstructions-and-uninjured-controls
#2
Jennifer L Bhatla, Andres Kroker, Sarah L Manske, Carolyn A Emery, Steven K Boyd
OBJECTIVE: Anterior cruciate ligament (ACL) tears increase early onset osteoarthritis (OA) risk leading to cartilage and bone degradation. While the contribution of bone in OA development is unclear, evidence suggests that bone changes accompany cartilage degradation. This study aims to assess if regions with differences in subchondral bone plate thickness have differences in cartilage thickness when comparing ACL reconstructed (ACLR) knees of women ≥5 years post-injury to contralateral and controls with uninjured knees...
April 17, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29675632/factors-affecting-mortality-and-reoperations-in-high-energy-pelvic-fractures
#3
Peyman Bakhshayesh, Lars Weidenhielm, Anders Enocson
AIM: Factors affecting mortality during the first year following high-energy pelvic fractures has not been reported previously. Nor has surgical complications leading to reoperations been reported in a cohort with only high-energy pelvic trauma patients. OBJECTIVES: The aim of this study was to report and analyse factors affecting outcome, in terms of mortality and reoperations, up to 1 year after the injury in patients with a traumatic pelvic ring injury due to a high-energy trauma...
April 19, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29667733/longitudinal-analysis-of-tibiofemoral-cartilage-contact-area-and-position-in-acl-reconstructed-patients
#4
Ellison Chen, Keiko Amano, Valentina Pedoia, Richard B Souza, C Benjamin Ma, Xiaojuan Li
Patients who have suffered ACL injury are more likely to develop early onset post-traumatic osteoarthritis despite reconstruction. The purpose of our study was to evaluate the longitudinal changes in the tibiofemoral cartilage contact area size and location after ACL injury and reconstruction. Thirty-one patients with isolated unilateral ACL injury were followed with T2 weighted Fast Spin Echo, T1ρ and T2 MRI at baseline prior to reconstruction, and 6 months, 1 year, and 2 years after surgery. Areas were delineated in FSE images with an in-house Matlab program using a spline-based semi-automated segmentation algorithm...
April 18, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29667227/effects-of-knockout-of-the-receptor-for-advanced-glycation-end-products-on-bone-mineral-density-and-synovitis-in-mice-with-intra-articular-fractures
#5
Dongrim Seol, Yuki Tochigi, Ashley M Bogner, Ino Song, Douglas C Fredericks, Gail L Kurriger, Sonja M Smith, Jessica E Goetz, Joseph A Buckwalter, James A Martin
Our group employed the mouse closed intra-articular fracture (IAF) model to test the hypothesis that the innate immune system plays a role in initiating synovitis and post-traumatic osteoarthritis (PTOA) in fractured joints. A transgenic strategy featuring knockout of the receptor for advanced glycation end-products (RAGE -/- ) was pursued. The 42 and 84 mJ impacts used to create fractures were in the range previously reported to cause PTOA at 60 days post-fracture. MicroCT (µCT) was used to assess fracture patterns and epiphyseal and metaphyseal bone loss at 30 and 60 days post-fracture...
April 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29601835/photoacoustic-imaging-of-synovial-tissue-hypoxia-in-experimental-post-traumatic-osteoarthritis
#6
REVIEW
Zhongyu Liu, Manting Au, Xuan Wang, Pok-Man Boris Chan, Puxiang Lai, Lei Sun, Yongping Zheng, Limin Rong, Chunyi Wen
OBJECTIVES: This pilot study aimed to investigate the feasibility of non-invasively assessing synovial tissue hypoxia in vivo using photoacoustic (PA) imaging in a post-traumatic osteoarthritis model and explore its correlation with OA severity. METHODS: The three-dimensional vasculature structure and oxygenation level of synovial tissues of destabilization of the medial meniscus (DMM)-induced osteoarthritis (OA) mice were longitudinally monitored using PA imaging...
March 27, 2018: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29600268/healing-of-complete-tear-of-the-anterior-talofibular-ligament-and-early-ankle-stabilization-after-autologous-platelet-rich-plasma-a-case-report-and-literature-review
#7
Mark Wai Wah Lai, Regina Wing Shan Sit
Lateral Ankle sprain (LAS) is a common sports injury associated with recurrent ankle sprain, chronic ankle instability (CAI) and post-traumatic ankle osteoarthritis (PTOA). Platelet Rich Plasma (PRP) has been increasingly used for herapeutic applications in sports-related injuries, and is thought to stimulate tissue healing. We reported a case of LAS with complete tear of anterior talofibular ligament, which showed complete healing of ligament and early ankle stabilization after PRP. The healing is supported by dynamic ultrasound images and magnetic resonance imaging...
March 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29598844/effect-of-bmi-on-outcomes-of-surgical-treatment-for-tibial-plateau-fractures-a-comparative-retrospective-case-series-study
#8
Yaşar Mahsut Dinçel, Ali Öner, Yavuz Arikan, Sever Çaglar, Raşit Özcafer, Mehmet Akif Güleç
PURPOSE: Tibia plateau fracture (TPF) treatment aims at achieving a stable, aligned, mobile, painless knee and preventing post-traumatic osteoarthritis. To achieve this goal, surgeons consider criteria such as patients' characteristics, severity, risk of complications, fracture displacement/depression, degree of soft tissue injury. However, body mass index (BMI) is not considered as a risk factor in literature. Our study was conducted to find out any possible correlation between BMI and functional scores or radiological score separately...
March 2, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29589504/long-term-results-of-the-lateral-resurfacing-elbow-arthroplasty
#9
C E L Watkins, D W Elson, J W K Harrison, J Pooley
Aim The aim of this study was to report the long-term outcome and implant survival of the lateral resurfacing elbow (LRE) arthroplasty in the treatment of elbow arthritis. Patients and Methods We reviewed a consecutive series of 27 patients (30 elbows) who underwent LRE arthroplasty between December 2005 and January 2008. There were 15 women and 12 men, with a mean age of 61 years (25 to 82). The diagnosis was primary hypotrophic osteoarthritis (OA) in 12 patients (14 elbows), post-traumatic osteoarthritis (PTOA) in five (five elbows) and rheumatoid arthritis (RA) in ten patients (11 elbows)...
March 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29575878/solec-spa-worldwide-unique-properties-of-polish-health-resort-in-the-service-of-rural-medicine
#10
Marek L Grabowski, Bożena Kosińska, Józef P Knap
Solec Spa is health resort in south-eastern Poland. Its unique balneorehabilitation significance worldwide is determined by chloride-iodine-sodium water with a high content of hydrogen sulphide. This water, classified as highly mineralized sodium-chloride (seltzer) sulphide, bromide, iodide, boron water, contains naturally approximately 0.9 g/l divalent sulphur compounds, which is the highest concentration noted among the mineral waters of the world. The effectiveness of the Solec waters is proven in: inflammatory and autoimmunological locomotor system diseases, degenerative joint disorders (osteoarthritis), post-traumatic and post-operative orthopedic diseases, skin diseases and allergic disorders...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29575548/evidence-that-mir-146a-attenuates-aging-and-trauma-induced-osteoarthritis-by-inhibiting-notch1-il-6-and-il-1-mediated-catabolism
#11
Ying-Jie Guan, Jing Li, Xu Yang, Shaohua Du, Jing Ding, Yun Gao, Ying Zhang, Kun Yang, Qian Chen
Primary osteoarthritis (OA) is associated with aging, while post-traumatic OA (PTOA) is associated with mechanical injury and inflammation. It is not clear whether the two types of osteoarthritis share common mechanisms. We found that miR-146a, a microRNA-associated with inflammation, is activated by cyclic load in the physiological range but suppressed by mechanical overload in human articular chondrocytes. Furthermore, miR-146a expression is decreased in the OA lesions of human articular cartilage. To understand the role of miR-146a in osteoarthritis, we systemically characterized mice in which miR-146a is either deficient in whole body or overexpressed in chondrogenic cells specifically...
March 24, 2018: Aging Cell
https://www.readbyqxmd.com/read/29575090/gait-mechanics-and-tibiofemoral-loading-in-men-of-the-acl-sports-randomized-control-trial
#12
Jacob J Capin, Ashutosh Khandha, Ryan Zarzycki, Amelia J H Arundale, Melissa L Ziegler, Kurt Manal, Thomas S Buchanan, Lynn Snyder-Mackler
The risk for post-traumatic osteoarthritis is elevated after anterior cruciate ligament reconstruction (ACLR), and may be especially high among individuals with aberrant walking mechanics, such as medial tibiofemoral joint underloading 6 months postoperatively. Rehabilitation training programs have been proposed as one strategy to address aberrant gait mechanics. We developed the anterior cruciate ligament specialized post-operative return-to-sports (ACL-SPORTS) randomized control trial to test the effect of 10 post-operative training sessions consisting of strength, agility, plyometric, and secondary prevention exercises (SAPP) or SAPP plus perturbation (SAPP + PERT) training on gait mechanics after ACLR...
March 25, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29555896/talar-neck-fracture-with-dislocation-combined-with-bimalleolar-ankle-fracture-a-case-report
#13
Ahmad M Radaideh, Ziad A Audat, Abdullah A Saleh
BACKGROUND Fractures of the talus are uncommon injuries that usually involve the talar neck, rather than the talar body. This report is of a rare case of combined left talar neck fracture and adjacent joint dislocation with an ipsilateral bimalleolar ankle fracture. CASE REPORT A 37-year-old man presented with an injury to his left foot following a motor vehicle accident. When he presented to the hospital emergency department, his left foot and ankle were swollen, the overlying skin was intact but badly contused, and there was no neurovascular deficit...
March 20, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29555825/tyrosine-kinase-fyn-promotes-osteoarthritis-by-activating-the-%C3%AE-catenin-pathway
#14
Kai Li, Yue Zhang, Yuwei Zhang, Wenqing Jiang, Junhui Shen, Song Xu, Daozhang Cai, Jie Shen, Bin Huang, Mangmang Li, Qiancheng Song, Yu Jiang, Anling Liu, Xiaochun Bai
OBJECTIVES: To investigate the role of tyrosine kinase Fyn in the development of osteoarthritis (OA) and the underlying mechanisms, and to define whether targeting Fyn could prevent OA in mice. METHODS: Cartilage samples from normal and aged mice were analysed with proteome-wide screening. Fyn expression was examined with immunofluorescence in human and age-dependent or experimental mouse OA cartilage samples. Experimental OA in Fyn-knockout mice was induced by destabilisation of the medial meniscus...
March 19, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29537955/perilunate-injuries-and-dislocations-etiology-diagnosis-and-management
#15
Nicole Montero Lopez, Nader Paksima
Perilunate injuries most commonly occur in high energy trauma situations; however, they are rare and frequently missed. Familiarity with the complex bony and ligamentous anatomy is required to fully understand these complex injury patterns. Careful orthogonal imaging and evaluation is required to ensure timely diagnosis of a perilunate injury. Early recognition and management of acute perilunate injuries has been demonstrated to correlate with better patient outcomes. Delayed treatment of chronic injuries can result in post-traumatic osteoarthritis and carpal collapse requiring salvage interventions...
March 2018: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/29526780/subchondral-bone-microarchitecture-in-acl-reconstructed-knees-of-young-women-a-comparison-with-contralateral-and-uninjured-control-knees
#16
Andres Kroker, Jennifer L Bhatla, Carolyn A Emery, Sarah L Manske, Steven K Boyd
Anterior cruciate ligament (ACL) tears are a common sports-related knee injury that increases the risk of developing post-traumatic osteoarthritis (OA). During OA progression bone microarchitecture changes in the affected knee, however, little is known about bone microarchitecture in knees with early stage OA. The purpose of this study is to investigate in a cohort of females predisposed to develop OA how bone microarchitecture in ACL reconstructed knees differs from uninjured contralateral knees as well as healthy control knees and how this relates to early changes in OA...
March 8, 2018: Bone
https://www.readbyqxmd.com/read/29523117/prevalence-of-and-characteristics-associated-with-insomnia-and-obstructive-sleep-apnea-among-veterans-with-knee-and-hip-osteoarthritis
#17
Shannon Stark Taylor, Jaime M Hughes, Cynthia J Coffman, Amy S Jeffreys, Christi S Ulmer, Eugene Z Oddone, Hayden B Bosworth, William S Yancy, Kelli D Allen
BACKGROUND: Few studies have examined patterns of specific sleep problems among individuals with osteoarthritis (OA). The primary objective of this study was to examine prevalence of symptoms of insomnia and obstructive sleep apnea (OSA) among Veterans with OA. Secondary objectives were to assess proportions of individuals with insomnia and OSA symptoms who may have been undiagnosed and to examine Veterans' characteristics associated with insomnia and OSA symptoms. METHODS: Veterans (n = 300) enrolled in a clinical trial completed the Insomnia Severity Index (ISI) and the Berlin Questionnaire (BQ) at baseline; proportions of participants with symptoms consistent with insomnia and OSA were calculated, using standard cut-offs for ISI and BQ...
March 9, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29471191/peak-knee-biomechanics-and-limb-symmetry-following-unilateral-anterior-cruciate-ligament-reconstruction-associations-of-walking-gait-and-jump-landing-outcomes
#18
Steven J Pfeiffer, J Troy Blackburn, Brittney Luc-Harkey, Matthew S Harkey, Laura E Stanley, Barnett Frank, Darin Padua, Stephen W Marshall, Jeffrey T Spang, Brian Pietrosimone
BACKGROUND: Aberrant walking-gait and jump-landing biomechanics may influence the development of post-traumatic osteoarthritis and increase the risk of a second anterior cruciate ligament injury, respectively. It remains unknown if individuals who demonstrate altered walking-gait biomechanics demonstrate similar altered biomechanics during jump-landing. Our aim was to determine associations in peak knee biomechanics and limb-symmetry indices between walking-gait and jump-landing tasks in individuals with a unilateral anterior cruciate ligament reconstruction...
January 31, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29460983/transcriptional-profiling-of-synovium-in-a-porcine-model-of-early-post-traumatic-osteoarthritis
#19
Jakob T Sieker, Benedikt L Proffen, Kimberly A Waller, Kaitlyn E Chin, Naga Padmini Karamchedu, Matthew R Akelman, Gabriel S Perrone, Ata M Kiapour, Johannes Konrad, Braden C Fleming, Martha M Murray
To determine the transcriptional profile of synovium during the molecular phase of post-traumatic osteoarthritis, anterior cruciate ligament transections (ACL) were performed in 36 Yucatan minipigs. Equal numbers were randomly assigned to no further treatment, ACL reconstruction or repair. Perimeniscal synovium for histopathology and RNA-sequencing was harvested at 1 and 4 weeks post-operatively and from 6 healthy control animals. Microscopic synovitis scores significantly worsened at 1 (p < 0.001) and 4 weeks (p = 0...
February 20, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29453795/inflammatory-and-degenerative-phases-resulting-from-anterior-cruciate-rupture-in-a-non-invasive-murine-model-of-post-traumatic-osteoarthritis
#20
Sophie Jane Gilbert, Cleo Selina Bonnet, Paulina Stadnik, Victor Colin Duance, Deborah JaneMason, Emma Jane Blain
Joint injury is the predominant risk factor for post-traumatic osteoarthritis development (PTOA). Several non-invasive mouse models mimicking human PTOA investigate molecular mechanisms of disease development; none have characterised the inflammatory response to this acute traumatic injury. Our aim was to characterise the early inflammatory phase and later degenerative component in our in vivo non-invasive murine model of PTOA induced by anterior cruciate ligament (ACL) rupture. Right knees of 12-week-old C57Bl6 mice were placed in flexion at a 30° offset position and subjected to a single compressive load (12N, 1...
February 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
keyword
keyword
21107
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"