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Post traumatic osteoarthritis

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https://www.readbyqxmd.com/read/28636254/pirfenidone-reduces-subchondral-bone-loss-and-fibrosis-after-murine-knee-cartilage-injury
#1
Deva D Chan, Jun Li, Wei Luo, Dan N Predescu, Brian J Cole, Anna Plaas
Pirfenidone is an anti-inflammatory and anti-fibrotic drug that has shown efficacy in lung and kidney fibrosis. Because inflammation and fibrosis have been linked to the progression of osteoarthritis, we investigated the effects of oral Pirfenidone in a mouse model of cartilage injury, which results in chronic inflammation and joint-wide fibrosis in mice that lack hyaluronan synthase 1 (Has1(-/-) ) in comparison to wild-type. Femoral cartilage was surgically injured in wild-type and Has1(-/-) mice, and Pirfenidone was administered in food starting after 3 days...
June 21, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28574124/total-hip-arthroplasty-in-young-patients-with-post-traumatic-arthritis-of-the-hip
#2
Ishaan Swarup, Ryan Sutherland, Jayme C Burket, Mark P Figgie
BACKGROUND: Post-traumatic arthritis of the hip is a degenerative condition that commonly affects young patients. In this study, we evaluate long-term implant survival and patient-reported outcomes after primary total hip arthroplasty (THA) in patients aged 35 or younger with post-traumatic arthritis of the hip. METHODS: We conducted a retrospective study with follow-up. A chart review was performed to identify young patients with post-traumatic arthritis of the hip treated with primary THA...
May 23, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28552760/denervation-of-the-wrist%C3%A2-with-two-surgical-incisions-is-it-effective-a-review-of-33-patients-with-an-average-of-41months-follow-up
#3
S Delclaux, F Elia, C Bouvet, C Aprédoaei, M Rongières, P Mansat
The goal of wrist denervation is to decrease pain at the wrist, whether caused by an intra- or extra-articular problem or even when the reason for the pain is unknown. It is an alternative to partial or total arthrodesis and proximal row carpectomy. Our hypothesis was that wrist denervation with a two-incision technique was a reliable and efficient way to treat painful degenerative wrists. Thirty-three patients, 48years old on average, were included in this study. Indications were scapholunate advanced collapse (SLAC) in 18 cases, scaphoid nonunion advanced collapse (SNAC) in 10, distal radius fracture sequelae with advanced radiocarpal osteoarthritis in 4, and post-traumatic ulnocarpal impingement in 1 case...
May 25, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28535749/analysis-of-change-in-gait-in-the-ovine-stifle-normal-injured-and-anterior-cruciate-ligament-reconstructed
#4
B J Heard, J E Beveridge, M Atarod, E J O'Brien, C Rolian, C B Frank, D A Hart, N G Shrive
BACKGROUND: Many patients who undergo anterior cruciate ligament (ACL) reconstructive surgery develop post-traumatic osteoarthritis (PTOA). ACL reconstructive surgery may not fully restore pre-injury joint biomechanics, thereby resulting in further joint damage and contributing to the development of PTOA. In an ovine model of idealized ACL reconstruction (ACL-R), it has been shown that signs of PTOA develop within surgical joints by 20 weeks post-surgery. The aim of the present study was to investigate whether altered kinematics contribute to early PTOA development within ACL-R joints of the ovine injury model by comparing the gait of these surgical animals to the gait of a stable normal control group, and an unstable injury group in which the ACL and medial collateral ligament (MCL) had been transected...
May 23, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28488001/lateral-displacement-sulcus-angle-and-trochlear-angle-are-associated-with-early-patellofemoral-osteoarthritis-following-anterior-cruciate-ligament-reconstruction
#5
Erin M Macri, Adam G Culvenor, Hayden G Morris, Timothy S Whitehead, Trevor G Russell, Karim M Khan, Kay M Crossley
PURPOSE: Patellofemoral osteoarthritis (PFOA) occurs in approximately half of anterior cruciate ligament (ACL)-injured knees within 10-15 years of trauma. Risk factors for post-traumatic PFOA are poorly understood. Patellofemoral alignment and trochlear morphology may be associated with PFOA following ACL reconstruction (ACLR), and understanding these relationships, particularly early in the post-surgical time period, may guide effective early intervention strategies. In this study, patellofemoral alignment and trochlear morphology were investigated in relation to radiographic features of early PFOA 1-year post-ACLR...
May 9, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28484796/fusion-of-the-subtalar-joint-for-post-traumatic-arthrosis-a-study-of-functional-outcomes-and-non-unions
#6
Patrick Ziegler, Jan Friederichs, Sven Hungerer
BACKGROUND: The aim of this prospective cohort study was to quantify the rate of non-unions after arthrodesis of the subtalar joint, to identify risk factors and to evaluate the functional outcome. METHODS: Patients with subtalar fusion from 2000 to 2013 and pre-existing post-traumatic osteoarthritis of the subtalar joint were analysed for risk factors like revision surgery, infection history in the area of operation, obesity, diabetes, cigarette smoking and alcohol abuse...
May 8, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28470440/-fifteen%C3%A2-years-of-the-histopathological-synovitis-score-review-and-further-developments-of%C3%A2-a%C3%A2-diagnostic-score
#7
REVIEW
V Krenn, G Perino, W Rüther, V T Krenn, M Huber, T Hügle, A Najm, S Müller, F Boettner, F Pessler, W Waldstein, J Kriegsmann, T Häupl, S Wienert, M G Krukemeyer, S Sesselmann, R Tikhilov, L Morawietz
The histopathological synovitis score evaluates in a graded approach, as is largely usual for diagnostic histopathological scores, the immunological and inflammatory changes caused by synovitis. A synovitis score of between 1 and ≤ 4 is classified as low-grade (osteoarthritis-related synovitis, post-traumatic synovitis, meniscopathy-related synovitis and synovitis in hemochromatosis). Synovitis scores of between ≥ 5 and 9 are classified as high-grade synovitis (rheumatoid arthritis, psoriatic arthritis, Lyme's arthritis, post-infection/reactive arthritis and peripheral arthritis in Bechterew disease); sensitivity is 61...
May 3, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28442207/tibio-talo-calcaneal-fusion-after-limb-salvage-procedures-a-retrospective-study
#8
Lukas Zak, Gerald E Wozasek
BACKGROUND: The treatment of limb threatening trauma on the distal tibia or hindfoot often results in posttraumatic osteoarthritis requiring tibiotalocalcaneal (TTC) arthrodesis. The purpose of this study was to present a case series of patients undergoing various techniques of joint fusion after bone reconstruction and deformity correction as a salvage procedure. The study should help trauma surgeons making decisions in limb salvage and deformity correction in complex lower leg and foot injuries by presenting options and treatment strategies...
April 15, 2017: Injury
https://www.readbyqxmd.com/read/28436958/local-clearance-of-senescent-cells-attenuates-the-development-of-post-traumatic-osteoarthritis-and-creates-a-pro-regenerative-environment
#9
Ok Hee Jeon, Chaekyu Kim, Remi-Martin Laberge, Marco Demaria, Sona Rathod, Alain P Vasserot, Jae Wook Chung, Do Hun Kim, Yan Poon, Nathaniel David, Darren J Baker, Jan M van Deursen, Judith Campisi, Jennifer H Elisseeff
Senescent cells (SnCs) accumulate in many vertebrate tissues with age and contribute to age-related pathologies, presumably through their secretion of factors contributing to the senescence-associated secretory phenotype (SASP). Removal of SnCs delays several pathologies and increases healthy lifespan. Aging and trauma are risk factors for the development of osteoarthritis (OA), a chronic disease characterized by degeneration of articular cartilage leading to pain and physical disability. Senescent chondrocytes are found in cartilage tissue isolated from patients undergoing joint replacement surgery, yet their role in disease pathogenesis is unknown...
June 2017: Nature Medicine
https://www.readbyqxmd.com/read/28410956/nine-year-outcome-after-anatomic-stemless-shoulder-prosthesis-clinical-and-radiologic-results
#10
Nael Hawi, Petra Magosch, Mark Tauber, Sven Lichtenberg, Peter Habermeyer
BACKGROUND: Several stemless shoulder implants are available on the market, but only a few studies have presented results with sufficient mid- to long-term follow-up. The present study evaluated clinical and radiologic outcomes 9 years after anatomic stemless shoulder replacement. METHODS: This is a prospective cohort study evaluating the stemless shoulder prosthesis since 2005. Anatomic stemless shoulder replacement using a single prosthesis was performed in 49 shoulders; 17 underwent total shoulder replacement, and 32 underwent hemiarthroplasty...
April 11, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28406954/therapeutic-efficacy-of-intra-articular-hyaluronan-derivative-and-platelet-rich-plasma-in-mice-following-axial-tibial-loading
#11
Xin Duan, Linda J Sandell, Nobuaki Chinzei, Nilsson Holguin, Matthew J Silva, Antonella Schiavinato, Muhammad Farooq Rai
OBJECTIVE: To investigate the therapeutic potential of intra-articular hyaluronan-derivative HYADD® 4-G and/or platelet-rich plasma (PRP) in a mouse model of non-invasive joint injury. METHODS: Non-invasive axial tibial loading was used to induce joint injury in 10-week-old C57BL/6J mice (n = 86). Mice underwent a single loading of either 6 Newton (N) or 9N axial tibial compression. HYADD® 4-G was injected intra-articularly at 8 mg/mL or 15 mg/mL either before or after loading with or without PRP...
2017: PloS One
https://www.readbyqxmd.com/read/28391430/why-does-total-elbow-arthroplasty-fail-today-a-systematic-review-of-recent-literature
#12
Ante Prkic, Chantal Welsink, Bertram The, Michel P J van den Bekerom, Denise Eygendaal
BACKGROUND: Total elbow arthroplasty is a relatively uncommon type of arthroplasty, which has undergone several design changes in the past four decades. However, research on improvement requires knowledge of failure mechanisms that can be addressed. Therefore, we conducted a systematic review on modes of failure of total elbow arthroplasty. METHODS: We conducted searches on PubMed/Medline, Embase and Cochrane databases to identify studies describing modes of failure of primary total elbow arthroplasties...
April 9, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28383764/risk-factors-for-radiographic-joint-space-narrowing-and-patient-reported-outcomes-of-post-traumatic-osteoarthritis-after-acl-reconstruction-data-from-the-moon-cohort
#13
Morgan H Jones, Kurt P Spindler
The Multicenter Orthopaedic Outcomes Network (MOON) is an NIH-funded prospective, longitudinal cohort of over 3,500 patients who have undergone anterior cruciate ligament reconstruction (ACLR) by 14 sports medicine surgeons at 7 academic medical centers. Patient reported outcome questionnaires (PRO's) are completed at baseline and multiple timepoints after surgery, and a nested cohort of patients return for radiographs to assess the development of joint space changes. We review the risk factors for worse patient reported outcomes, the predictors of clinically significant symptoms of post-traumatic osteoarthritis (PTOA), and the factors associated with more radiographic joint space narrowing...
April 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28345597/post-traumatic-osteoarthritis-in-mice-following-mechanical-injury-to-the-synovial-joint
#14
Muhammad Farooq Rai, Xin Duan, James D Quirk, Nilsson Holguin, Eric J Schmidt, Nobuaki Chinzei, Matthew J Silva, Linda J Sandell
We investigated the spectrum of lesions characteristic of post-traumatic osteoarthritis (PTOA) across the knee joint in response to mechanical injury. We hypothesized that alteration in knee joint stability in mice reproduces molecular and structural features of PTOA that would suggest potential therapeutic targets in humans. The right knees of eight-week old male mice from two recombinant inbred lines (LGXSM-6 and LGXSM-33) were subjected to axial tibial compression. Three separate loading magnitudes were applied: 6N, 9N, and 12N...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28297745/special-issue-injury-and-post-traumatic-osteoarthritis
#15
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28284669/subchondral-bone-microarchitecture-and-failure-mechanism-under-compression-a-finite-element-study
#16
Fatemeh Malekipour, Denny Oetomo, Peter Vee-Sin Lee
Subchondral bone (SCB) microdamage is commonly observed in traumatic joint injuries and has been strongly associated with post-traumatic osteoarthritis (PTOA). Knowledge of the three-dimensional stress and strain distribution within the SCB tissue helps to understand the mechanism of SCB failure, and may lead to an improved understanding of mechanisms of PTOA initiation, prevention and treatment. In this study, we used high-resolution micro-computed tomography (µCT)-based finite element (FE) modelling of cartilage-bone to evaluate the failure mechanism and the locations of SCB tissue at high-risk of initial failure under compression...
April 11, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28280907/high-prevalence-of-knee-osteoarthritis-at-a-minimum-10-year-follow-up-after-knee-dislocation-surgery
#17
Gilbert Moatshe, Grant J Dornan, Tom Ludvigsen, Sverre Løken, Robert F LaPrade, Lars Engebretsen
PURPOSE: Long-term outcomes and the prevalence of osteoarthritis after surgical treatment of knee dislocations are lacking in the literature. The purpose of this study was to investigate the prevalence of knee osteoarthritis and knee function at a minimum of 10 years after knee dislocation surgery. METHODS: Sixty-five patients surgically treated for knee dislocations at a single level I trauma center between May 1996 and December 2004 were evaluated at a minimum of 10 years...
March 9, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28267190/changes-in-joint-contact-mechanics-in-a-large-quadrupedal-animal-model-after-partial-meniscectomy-and-a-focal-cartilage-injury
#18
David J Heckelsmiller, M James Rudert, Thomas E Baer, Douglas R Pedersen, Douglas C Fredericks, Jessica E Goetz
Acute mechanical damage and the resulting joint contact abnormalities are central to the initiation and progression of post-traumatic osteoarthritis (PTOA). Study of PTOA is typically performed in vivo with replicate animals using artificially induced injury features. The goal of this work was to measure changes in a joint contact stress in the knee of a large quadruped after creation of a clinically realistic overload injury and a focal cartilage defect. Whole-joint overload was achieved by excising a 5-mm wedge of the anterior medial meniscus...
May 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28252005/serum-snornas-as-biomarkers-for-joint-ageing-and-post-traumatic-osteoarthritis
#19
Mandy M F Steinbusch, Yongxiang Fang, Peter I Milner, Peter D Clegg, David A Young, Tim J M Welting, Mandy J Peffers
The development of effective treatments for the age-related disease osteoarthritis and the ability to predict disease progression has been hampered by the lack of biomarkers able to demonstrate the course of the disease. Profiling the expression patterns of small nucleolar RNAs (snoRNAs) in joint ageing and OA may provide diagnostic biomarkers and therapeutic targets. This study determined expression patterns of snoRNAs in joint ageing and OA and examined them as potential biomarkers. Using SnoRNASeq and real-time quantitative PCR (qRT-PCR) we demonstrate snoRNA expression levels in murine ageing and OA joints and serum for the first time...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28251061/total-knee-arthroplasty-and-fractures-of-the-tibial-plateau
#20
REVIEW
Kenneth A Softness, Ryan S Murray, Brian G Evans
Tibial plateau fractures are common injuries that occur in a bimodal age distribution. While there are various treatment options for displaced tibial plateau fractures, the standard of care is open reduction and internal fixation (ORIF). In physiologically young patients with higher demand and better bone quality, ORIF is the preferred method of treating these fractures. However, future total knee arthroplasty (TKA) is a consideration in these patients as post-traumatic osteoarthritis is a common long-term complication of tibial plateau fractures...
February 18, 2017: World Journal of Orthopedics
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