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Post traumatic osteoarthritis

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https://www.readbyqxmd.com/read/29038190/effect-of-autologous-adipose-derived-mesenchymal-stem-cell-therapy-in-the-treatment-of-a-post-traumatic-chondral-defect-of-the-knee
#1
Julien Freitag, Douglas Li, James Wickham, Kiran Shah, Abi Tenen
Isolated chondral defects have a limited capacity to heal and predispose to the development of osteoarthritis. Current surgical management can be unpredictable in outcome. Improved understanding of the action of mesenchymal stem cells (MSCs) has seen renewed interest in their role in cartilage repair. A 26-year-old athlete presented with a post-traumatic, isolated patella chondral defect. The patient underwent an arthroscopy with removal of a chondral loose body. After failure to symptomatically improve 12 months following surgery, the patient received intra-articular autologous adipose-derived mesenchymal stem cell (ADMSC) therapy...
October 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29026147/vascular-endothelial-growth-factor-in-cartilage-development-and-osteoarthritis
#2
Masashi Nagao, John L Hamilton, Ranjan Kc, Agnes D Berendsen, Xuchen Duan, Chan Wook Cheong, Xin Li, Hee-Jeong Im, Bjorn R Olsen
Genome wide studies indicate that vascular endothelial growth factor A (VEGF) is associated with osteoarthritis (OA), and increased VEGF expression correlates with increased disease severity. VEGF is also a chondrocyte survival factor during development and essential for bone formation, skeletal growth and postnatal homeostasis. This raises questions of how the important embryonic and postnatal functions of VEGF can be reconciled with an apparently destructive role in OA. Addressing these questions, we find that VEGF acts as a survival factor in growth plate chondrocytes during development but only up until a few weeks after birth in mice...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28987873/hip-joint-biomechanics-in-those-with-and-without-post-traumatic-knee-osteoarthritis-after-anterior-cruciate-ligament-injury
#3
E Wellsandt, J A Zeni, M J Axe, L Snyder-Mackler
BACKGROUND: Anterior cruciate ligament injury results in altered kinematics and kinetics in the knee and hip joints that persist despite surgical reconstruction and rehabilitation. Abnormal movement patterns and a history of osteoarthritis are risk factors for articular cartilage degeneration in additional joints. The purpose of this study was to determine if hip joint biomechanics early after anterior cruciate ligament injury and reconstruction differ between patients with and without post-traumatic knee osteoarthritis 5years after reconstruction...
October 2, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28965142/improvement-in-the-medial-meniscus-posterior-shift-following-anterior-cruciate-ligament-reconstruction
#4
Hiroto Inoue, Takayuki Furumatsu, Shinichi Miyazawa, Masataka Fujii, Yuya Kodama, Toshifumi Ozaki
PURPOSE: Anterior cruciate ligament (ACL) reconstruction can reduce the risk of developing osteoarthritic knees. The goals of ACL reconstruction are to restore knee stability and reduce post-traumatic meniscal tears and cartilage degradation. A chronic ACL insufficiency frequently results in medial meniscus (MM) injury at the posterior segment. How ACL reconstruction can reduce the deformation of the MM posterior segment remains unclear. In this study, we evaluated the form of the MM posterior segment and anterior tibial translation before and after ACL reconstruction using open magnetic resonance imaging (MRI)...
September 30, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28963163/cemented-total-hip-arthroplasty-following-acetabular-fracture
#5
C E H Scott, D MacDonald, M Moran, T O White, J T Patton, J F Keating
AIMS: To evaluate the outcomes of cemented total hip arthroplasty (THA) following a fracture of the acetabulum, with evaluation of risk factors and comparison with a patient group with no history of fracture. PATIENTS AND METHODS: Between 1992 and 2016, 49 patients (33 male) with mean age of 57 years (25 to 87) underwent cemented THA at a mean of 6.5 years (0.1 to 25) following acetabular fracture. A total of 38 had undergone surgical fixation and 11 had been treated non-operatively; 13 patients died at a mean of 10...
October 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28939032/preoperative-diagnosis-can-predict-conversion-total-knee-arthroplasty-outcomes
#6
David H Ge, Afshin A Anoushiravani, Benjamin S Kester, Jonathan M Vigdorchik, Ran Schwarzkopf
BACKGROUND: Compared to total knee arthroplasty (TKA) for primary osteoarthritis, conversion TKAs in the post-traumatic setting are associated with increased operative times, infection rates, and readmissions. We aim at determining how post-traumatic osteoarthritis and previous knee surgery influence postoperative outcomes in conversion TKA. METHODS: Seventy-two conversion TKA procedures with prior knee trauma at a single institution between April 2012 and 2016 were examined...
August 24, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28919498/accelerated-return-to-sport-after-acl-reconstruction-and-early-knee-osteoarthritis-features-at-1-year-an-exploratory-study
#7
Adam G Culvenor, Brooke E Patterson, Ali Guermazi, Hayden G Morris, Timothy S Whitehead, Kay M Crossley
BACKGROUND: A timely return to competitive sport is a primary goal of anterior cruciate ligament reconstruction (ACLR). It is not known if an accelerated return-to-sport increases the risk of early-onset knee osteoarthritis (KOA). OBJECTIVE: To determine whether an accelerated return-to-sport post-ACLR (i.e., <10 months) is associated with increased odds of early KOA features on MRI 1-year post-surgery, and to evaluate the relationship between an accelerated return-to-sport and early KOA features stratified by type of ACL injury (isolated or concurrent chondral/meniscal injury) and lower-limb function (good or poor)...
September 14, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28919430/role-of-subchondral-bone-properties-and-changes-in-development-of-load-induced-osteoarthritis-in-mice
#8
O O Adebayo, F C Ko, P T Wan, S R Goldring, M B Goldring, T M Wright, M C H van der Meulen
OBJECTIVE: Animal models recapitulating post-traumatic osteoarthritis (OA) suggest that subchondral bone (SCB) properties and remodeling may play major roles in disease initiation and progression. Thus, we investigated the role of SCB properties and its effects on load-induced OA progression by applying a tibial loading model on two distinct mouse strains treated with alendronate (ALN). DESIGN: Cyclic compression was applied to the left tibia of 26-week-old male C57Bl/6 (B6, low bone mass) and FVB (high bone mass) mice...
September 14, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28904358/monitoring-osteoarthritis-progression-using-near-infrared-nir-spectroscopy
#9
Isaac O Afara, Indira Prasadam, Zohreh Arabshahi, Yin Xiao, Adekunle Oloyede
We demonstrate in this study the potential of near infrared (NIR) spectroscopy as a tool for monitoring progression of cartilage degeneration in an animal model. Osteoarthritic degeneration was artificially induced in one joint in laboratory rats, and the animals were sacrificed at four time points: 1, 2, 4, and 6 weeks (3 animals/week). NIR spectra were acquired from both (injured and intact) knees. Subsequently, the joint samples were subjected to histological evaluation and glycosaminoglycan (GAG) content analysis, to assess disease severity based on the Mankin scoring system and to determine proteoglycan loss, respectively...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875272/lars%C3%A2-in-acl-reconstruction-evaluation-of-60-cases-with-5-year-minimum-follow-up
#10
G Bugelli, G Dell'Osso, F Ascione, E Gori, V Bottai, S Giannotti
PURPOSE: The injury of anterior cruciate ligament (ACL) causes joint instability and, in the absence of adequate treatment, progressive joint deterioration, meniscal lesions and development of post-traumatic osteoarthritis. METHODS: The purpose of this study was to evaluate the clinical, functional and radiographic outcomes and complications in a consecutive case series of 60 patients with minimum follow-up of 5 years who underwent an arthroscopic surgery for ACL reconstruction using LARS™ ligament...
September 5, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28871360/the-aes-total-ankle-arthroplasty-analysis-of-failures-and-survivorship-at-ten-years
#11
Alexandre Di Iorio, Anthony Viste, Michel Henry Fessy, Jean Luc Besse
BACKGROUND: AES mobile-bearing total ankle replacement was developed from the Buechel Pappas model. It was withdrawn in 2009, after identification of a higher than expected complication rate. The purpose of the current study was to analyse clinical outcomes, failures and survival of the initial series of 50 AES published in 2009. METHODS: In this single-centre continuous prospective study (2003-2006), 50 AES prostheses were included. Pre-operative osteoarthritis was mainly post-traumatic (50%) and secondary to instability (36%)...
September 4, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28834244/striking-a-new-path-in-reducing-cartilage-breakdown-combination-of-antioxidative-therapy-and-chondroanabolic-stimulation-after-blunt-cartilage-trauma
#12
Jana Riegger, Helga Joos, Hans-Georg Palm, Benedikt Friemert, Heiko Reichel, Anita Ignatius, Rolf E Brenner
Cartilage injury can trigger crucial pathomechanisms, including excessive cell death and expression of matrix-destructive enzymes, which contribute to the progression of a post-traumatic osteoarthritis (PTOA). With the intent to create a novel treatment strategy for alleviating trauma-induced cartilage damage, we complemented a promising antioxidative approach based on cell and chondroprotective N-acetyl cysteine (NAC) by chondroanabolic stimulation. Overall, three potential pro-anabolic growth factors - IGF-1, BMP7 and FGF18 - were tested comparatively with and without NAC in an ex vivo human cartilage trauma-model...
August 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28810618/sivelestat-sodium-hydrate-improves-post-traumatic-knee-osteoarthritis-through-nuclear-factor-%C3%AE%C2%BAb-in-a-rat-model
#13
Xiaofeng Yu, Lijun Zhao, Zhiping Yu, Changzheng Yu, Jianfei Bi, Binglong Sun, Haibo Cong
As a specific inhibitor of neutrophil elastase, sivelestat sodium hydrate has primarily been used in the treatment of acute lung injury caused by various factors since its approval in 2002. Sivelestat sodium hydrate also improves post-traumatic knee osteoarthritis (KOA), although its underlying mechanisms of action have yet to be elucidated. The aim of the current study was to determine if sivelestat sodium hydrate improves post-traumatic KOA through nuclear factor (NF)-κB in a rat model. Treatment with sivelestat sodium hydrate significantly inhibited the induction of structural changes and significantly increased the vertical episode count and ipsilateral static weight bearing of the joint in KOA rats (all P<0...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28808631/painless-swollen-calf-muscles-of-a-75-year-old-patient-caused-by-bilateral-venous-malformations
#14
Roderick S M Piekaar, Eline W Zwitser, Paul P A Hedeman Joosten, Joris A Jansen
A 75-year-old man presented with knee pain due to medial osteoarthritis of the knee in the orthopedic outpatient clinic. Conservative treatment was started with steroid infiltration. Besides his knee complaint reported a bilateral painless swollen calf muscle without traumatic cause, and also without any pain at night, fever or medical illness. On physical examination the soleus muscle had a swollen aspect in both calfs. The skin appeared normal without deformities and the arterial pulsations were intact. An X-ray did not show abnormalities in the tibia...
July 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28768528/safety-tolerability-clinical-and-joint-structural-outcomes-of-a-single-intra-articular-injection-of-allogeneic-mesenchymal-precursor-cells-in-patients-following-anterior-cruciate-ligament-reconstruction-a-controlled-double-blind-randomised-trial
#15
Yuanyuan Wang, Andrew Shimmin, Peter Ghosh, Paul Marks, James Linklater, David Connell, Stephen Hall, Donna Skerrett, Silviu Itescu, Flavia M Cicuttini
BACKGROUND: Few clinical trials have investigated the safety and efficacy of mesenchymal stem cells for the management of post-traumatic osteoarthritis. The objectives of this pilot study were to determine the safety and tolerability and to explore the efficacy of a single intra-articular injection of allogeneic human mesenchymal precursor cells (MPCs) to improve clinical symptoms and retard joint structural deterioration over 24 months in patients following anterior cruciate ligament (ACL) reconstruction...
August 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28741321/-articular-fractures-of-the-distal-femur-comparative-analysis-of-three-surgical-treatments
#16
F Souki-Chmeit, E Zambrano-Sanguinetti, A Sandia-Briceño, A Souki-Chmeit, M Brito-Velásquez
INTRODUCTION: The distal articular femur fracture is a serious injury that for years has been a problem in traumatology. It is often believed that produced varying degrees of permanent disability in the knee and that the fate of the joint was determined by the injury rather than treatment. OBJECTIVES: Present the results of surgical treatment of articular distal femur fractures type C2 with three treatment modalities: dynamic condylar screw (TDC), condylar buttress plate (PSC) and periarticular plate (PPA)...
January 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28735822/conservative-management-of-a-traumatic-meniscal-injury-utilising-osteopathy-and-exercise-rehabilitation-a-case-report
#17
Jack Feehan, Chris Macfarlane, Brett Vaughan
Meniscal injury is one of the most common knee soft tissue injuries, commonly affecting young athletes and an older, degenerative population. Treatment largely depends on the type and extent of the injury with arthroscopic repair or meniscectomy being mainstays. Although non-surgical approaches have been described, there is no published literature regarding a combination of indirect osteopathic techniques and rehabilitation in the management of these injuries. The current case report follows a 20-year-old male presenting with a 5-day history of acute knee pain, following trauma during an Australian Rules Football (AFL) match...
August 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28735021/wisp1-ccn4-aggravates-cartilage-degeneration-in-experimental-osteoarthritis
#18
M H van den Bosch, A B Blom, V Kram, A Maeda, S Sikka, Y Gabet, T M Kilts, W B van den Berg, P L van Lent, P M van der Kraan, M F Young
OBJECTIVE: Increased Wisp1 expression was previously reported in experimental and human osteoarthritis (OA). Moreover, adenoviral overexpression of Wisp1 in naïve mouse knee joints resulted in early OA-like cartilage lesions. Here, we determined how the matricellular protein WISP1 is involved in the pathology that occurs in the complex osteoarthritic environment with aging and experimental OA in wild type (WT) and Wisp1(-/-) mice. METHODS: WT and Wisp1(-/-) mice were aged or experimental OA was induced with intraarticular collagenase injection, destabilization of the medial meniscus (DMM) or anterior cruciate ligament transection (ACLT)...
July 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28730928/feasibility-of-na-18-f-pet-ct-and-mri-for-noninvasive-in-vivo-quantification-of-knee-pathophysiological-bone-metabolism-in-a-canine-model-of-post-traumatic-osteoarthritis
#19
Maria I Menendez, Bianca Hettlich, Lai Wei, Michael V Knopp
PURPOSE: To assess and quantify by molecular imaging knee osseous metabolic changes serially in an in vivo canine model of posttraumatic osteoarthritis (PTOA) of the knee utilizing sodium fluoride (Na(18)F) positron emission tomography (PET)/computed tomography (CT) coregistered with magnetic resonance imaging (MRI). MATERIALS AND METHODS: Sodium fluoride PET imaging of 5 canines was performed prior to anterior cruciate ligament transection (ACLT) and 2 times post-ACLT (3 and 12 weeks)...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28729949/modeling-the-effect-of-blunt-impact-on-mitochondrial-function-in-cartilage-implications-for-development-of-osteoarthritis
#20
Georgi I Kapitanov, Bruce P Ayati, James A Martin
OBJECTIVE: Osteoarthritis (OA) is a disease characterized by degeneration of joint cartilage. It is associated with pain and disability and is the result of either age and activity related joint wear or an injury. Non-invasive treatment options are scarce and prevention and early intervention methods are practically non-existent. The modeling effort presented in this article is constructed based on an emerging biological hypothesis-post-impact oxidative stress leads to cartilage cell apoptosis and hence the degeneration observed with the disease...
2017: PeerJ
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