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Post traumatic osteoarthritis

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https://www.readbyqxmd.com/read/28069163/sub-critical-impact-inhibits-the-lubricating-mechanisms-of-articular-cartilage
#1
Edward D Bonnevie, Michelle L Delco, Devis Galesso, Cynthia Secchieri, Lisa A Fortier, Lawrence J Bonassar
Although post-traumatic osteoarthritis accounts for a significant proportion of all osteoarthritis, the understanding of both biological and mechanical phenomena that lead to cartilage degeneration in the years to decades after trauma is still lacking. In this study, we evaluate how cartilage lubrication is altered after a sub-critical impact (i.e., an impact to the cartilage surface that produces surface cracking but not full thickness fissuring). Through utilizing a Stribeck-like framework, the elastoviscous transition, we evaluated changes to both the innate boundary lubricating ability of cartilage after impact and also the effectiveness of high viscosity lubricants to lower friction after impact...
December 29, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28018086/leukocyte-poor-platelet-rich-plasma-to-treat-degenerative-meniscal-tear-a-case-report
#2
J P Betancourt, W D Murrell
A traumatic and/or degenerative meniscus lesion is thought to be a clinical manifestation of early-onset osteoarthritis (OA), which is a chronic progressive condition that can cause substantial pain and disability. Platelet-rich plasma (PRP) is an emerging treatment option that has been reported to improve healing. Here, we present a case of a 29-year-old woman, with left anterior and medial knee pain, without history of trauma or injury. The patient was managed with leukocyte-poor PRP injections derived from her peripheral blood with high concentrations of platelets, platelet-derived growth factors, and bioactive proteins, with a total follow-up of 30 months...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28005191/central-nervous-system-adaptation-after-ligamentous-injury-a-summary-of-theories-evidence-and-clinical-interpretation
#3
REVIEW
Alan R Needle, Adam S Lepley, Dustin R Grooms
The array of dysfunction occurring after ligamentous injury is tied to long-term clinical impairments in functional performance, joint stability, and health-related quality of life. To appropriately treat individuals, and in an attempt to avoid sequelae such as post-traumatic osteoarthritis, investigators have sought to better establish the etiology of the persistent dysfunction present in patients who have sustained joint ligament injuries to the lower extremities. Recent evidence has suggested that changes within the brain and central nervous system may underlie these functional deficits, with support arising from direct neurophysiologic measures of somatosensory dysfunction, motor system excitability, and plasticity of neural networks...
December 22, 2016: Sports Medicine
https://www.readbyqxmd.com/read/28003668/concurrent-lateral-meniscal-repair-with-anterior-cruciate-ligament-reconstruction-induces-the-extrusion-of-the-lateral-meniscus-assessments-of-magnetic-resonance-images
#4
Naoko Kashihara, Takayuki Furumatsu, Yuya Kodama, Takaaki Tanaka, Toshifumi Ozaki
Concurrent meniscal repair with anterior cruciate ligament (ACL) reconstruction has shown good clinical outcomes, but it has a considerable risk of progressing to post-traumatic osteoarthritis of the knee. Here we investigated postoperative changes in the position of the lateral meniscus (LM) and assessed the short-term clinical results after concurrent LM repair with ACL reconstruction. Twentyseven patients underwent LM repair of a peripheral longitudinal tear concomitant with ACL reconstruction. We evaluated the preoperative and postoperative values of the Lysholm score and anteroposterior instability...
December 2016: Acta Medica Okayama
https://www.readbyqxmd.com/read/27988350/quantitative-proteomics-analysis-of-cartilage-response-to-mechanical-injury-and-cytokine-treatment
#5
Yang Wang, Yang Li, Areej Khabut, Susan Chubinskaya, Alan J Grodzinsky, Patrik Önnerfjord
Mechanical damage at the time of joint injury and the ensuing inflammatory response associated with elevated levels of pro-inflammatory cytokines in the synovial fluid, are reported to contribute to the progression to osteoarthritis after injury. In this exploratory study, we used a targeted proteomics approach to follow the progression of matrix degradation in response to mechanical damage and cytokine treatment of human knee cartilage explants, and thereby to study potential molecular biomarkers. This proteomics approach allowed us to unambiguously identify and quantify multiple peptides and proteins in the cartilage medium and explants upon treatment with ±injurious compression ±cytokines, treatments that mimic the earliest events in post-traumatic OA...
December 15, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27981785/morphological-study-ultrastructural-aspects-of-articular-cartilage-and-sub-chondral-bone-in-patients-affected-by-post-traumatic-shoulder-instability
#6
Paolo Baudi, Fabio Catani, Manuela Rebuzzi, Marzia Ferretti, Alberto Smargiassi, Gabriele Campochiaro, Fabio Serafini, Carla Palumbo
Post-traumatic shoulder instability is a frequent condition in active population, representing one of most disabling pathologies, due to altered balance involving joints. No data are so far available on early ultrastructural osteo-chondral damages, associated with the onset of invalidating pathologies, like osteoarthritis-OA. Biopsies of glenoid articular cartilage and sub-chondral bone were taken from 10 adult patients underwent arthroscopic stabilization. Observations were performed under Transmission Electron Microscopy-TEM in tangential, arcuate and radial layers of the articular cartilage and in the sub-chondral bone...
December 16, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27965139/physiological-exercise-loading-suppresses-post-traumatic-osteoarthritis-progression-via-an-increase-in-bone-morphogenetic-proteins-expression-in-an-experimental-rat-knee-model
#7
H Iijima, A Ito, M Nagai, J Tajino, S Yamaguchi, W Kiyan, A Nakahata, J Zhang, T Wang, T Aoyama, K Nishitani, H Kuroki
OBJECTIVE: To evaluate the dose-response relationship of exercise loading in the cartilage-subchondral bone (SB) unit in surgically-induced post-traumatic osteoarthritis (PTOA) of the knee. DESIGN: Destabilized medial meniscus (DMM) surgery was performed on the right knee of 12-week-old male Wistar rats, and sham surgery was performed on the contralateral knee. Four weeks after the surgery, the animals were subjected to moderate (12 m/min) or intense (21 m/min) treadmill exercises for 30 min/day, 5 days/week for 4 weeks...
December 10, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27917354/results-of-a-hydroxyapatite-coated-femoral-stem-corail-in-chinese-a-minimum-10-year-follow-up
#8
Jianda Xu, Zikang Xie, Jianning Zhao, Yi Gao, Hong Zhao, Libo Peng, Yuxing Qu
BACKGROUND: Due to the adverse effects of cemented hip arthroplasty, uncemented stems with hydroxyapatite (HA) coating reduces these risks and enhanced integration. The concept of an extensive HA coating for the fixation of a tapered femoral stem (Corail(®)) was introduced, which can achieve durable biological fixation and preserve normal periprosthetic bone activity. Here we describe the clinical and radiological outcome in patients with the Corail(®) stem. METHODS: 92 total hip replacements in 81 patients using the Corail(®) stem were followed-up...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27909124/predicting-dissatisfaction-following-total-knee-arthroplasty-in-patients-under-55-years-of-age
#9
C E H Scott, W M Oliver, D MacDonald, F A Wade, M Moran, S J Breusch
AIMS: Risk of revision following total knee arthroplasty (TKA) is higher in patients under 55 years, but little data are reported regarding non-revision outcomes. This study aims to identify predictors of dissatisfaction in these patients. PATIENTS AND METHODS: We prospectively assessed 177 TKAs (157 consecutive patients, 99 women, mean age 50 years; 17 to 54) from 2008 to 2013. Age, gender, implant, indication, body mass index (BMI), social deprivation, range of movement, Kellgren-Lawrence (KL) grade of osteoarthritis (OA) and prior knee surgery were recorded...
December 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27903450/low-energy-impact-of-human-cartilage-predictors-for-microcracking-the-network-of-collagen
#10
B Kaleem, F Maier, H Drissi, D M Pierce
OBJECTIVE: We aimed to determine the minimum mechanical impact to cause microstructural damage in the network of collagen (microcracking) within human cartilage and hypothesized that energies below 0.1 J or 1 mJ/mm(3) would suffice. DESIGN: We completed 108 low-energy impact tests (0.05, 0.07, or 0.09 J; 0.75 or 1.0 m/s(2)) using healthy cartilage specimens from six male donors (30.2 ± 8.8 yrs old). Before and after impact we acquired, imaging the second harmonic generation (SHG), ten images from each specimen (50 μm depth, 5 μm step size), resulting in 2160 images...
November 27, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27900509/conversion-of-hip-fusion-to-total-hip-arthroplasty-clinical-radiological-outcomes-and-complications-in-40-hips
#11
Mustafa Celiktas, Ozkan Kose, Adil Turan, Ferhat Guler, Cagri Ors, Emre Togrul
OBJECTIVE: The purpose of this retrospective study is to report the clinical and radiological outcome of total hip arthroplasty in patients with previous hip arthrodesis. PATIENTS AND METHODS: We retrospectively reviewed 28 (40 hips) prospectively followed patients in whom ankylosed hips were converted to total hip arthroplasty (THA) between 2010 and 2014 in our institution. The average age at the time of the conversion operation was 40.8 ± 9.8 years (range 24-62)...
November 29, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27900304/clinical-outcome-of-design-modifications-to-the-cls-spotorno-stem-in-total-hip-replacement
#12
Angelo Graceffa, Pier Francesco Indelli, Leonardo Latella, Paolo Poli, Alexander Fulco, Massimiliano Marcucci
PURPOSE: historically, the original CLS Spotorno Stem has demonstrated excellent survival. The design of this stem was recently modified, resulting in the introduction of a shorter, modular version (CLS Brevius). The purpose of the current study was to evaluate the functional, radiological and survivorship outcomes of the cementless CLS Brevius Stem in a multi-surgeon, single center, consecutive series study at two years post-surgery. METHODS: the Authors performed 170 total hip arthroplasties in 155 patients using the shorter, triple-taper stem design (CLS Brevius)...
July 2016: Joints
https://www.readbyqxmd.com/read/27857506/short-to-mid-term-results-of-ulna-head-replacement-as-both-a-primary-and-revision-implant
#13
Tobias K A Baring, Ravi Popat, Ali Abdelwahab, Barry Ferris
: We present the results of short- to medium-term follow-up of 10 patients following ulna head replacement. The mean age of patients was 63.2 years (range 48-81 years), with the mean duration of follow-up being 48 months (12-88 months). The indications for the procedure were primary osteoarthritis (n = 3), post-traumatic osteoarthritis (n = 4), failed Darrach's procedure (n = 2) and rheumatoid arthritis (n = 1). Two patients required revision (20%), one for gross aseptic loosening of the stem and another for an initially oversized head...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/27849503/causes-of-primary-total-hip-arthroplasty-in-active-duty-soldiers-are-recurrent-medical-assessments-associated-with-reduced-rates-of-secondary-osteoarthritis-in-this-population
#14
Andreas Grözinger, Andreas Musa, Sascha Gravius, Thomas M Randau, Erwin Kollig
The purpose of this study was to analyze the different causes of symptomatic osteoarthritis (OA) of the hip joint in active duty soldiers requiring a total hip arthroplasty and the hypothesis that soldiers had a reduced prevalence of secondary OA as a result of a selection process that has taken place through multiple medical assessments during their military career. We analyzed patient records from 2006 to 2012 for male patients ≤60 years with OA of the hip and indication for total hip arthroplasty in a military hospital in which civilian patients are also treated...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27843894/linking-cellular-and-mechanical-processes-in-articular-cartilage-lesion-formation-a-mathematical-model
#15
Georgi I Kapitanov, Xiayi Wang, Bruce P Ayati, Marc J Brouillette, James A Martin
Post-traumatic osteoarthritis affects almost 20% of the adult US population. An injurious impact applies a significant amount of physical stress on articular cartilage and can initiate a cascade of biochemical reactions that can lead to the development of osteoarthritis. In our effort to understand the underlying biochemical mechanisms of this debilitating disease, we have constructed a multiscale mathematical model of the process with three components: cellular, chemical, and mechanical. The cellular component describes the different chondrocyte states according to the chemicals these cells release...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27821120/pro-inflammatory-cytokines-and-structural-biomarkers-are-effective-to-categorize-osteoarthritis-phenotype-and-progression-in-standardbred-racehorses-over-five-years-of-racing-career
#16
Andrea Bertuglia, Eleonora Pagliara, Elena Grego, Alessandro Ricci, Nika Brkljaca-Bottegaro
BACKGROUND: Joint impact injuries initiate a progressive articular damage finally leading to post-traumatic osteoarthritis (PTOA). Racehorses represent an ideal, naturally available, animal model of the disease. Standardbred racehorses developing traumatic osteoarthritis of the fetlock joint during the first year of their career were enrolled in our study. Age-matched controls were contemporarily included. Biomarker levels of equine osteoarthritis were measured in serum and synovial fluid (SF) at baseline, and repeated yearly over the next 4 years of training (from T1 to T4)...
November 8, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27813662/matrix-metalloproteinase-activity-and-prostaglandin-e2-are-elevated-in-the-synovial-fluid-of-meniscus-tear-patients
#17
Betty Liu, Adam P Goode, Teralyn E Carter, Gangadhar M Utturkar, Janet L Huebner, Dean C Taylor, Claude T Moorman Iii, William E Garrett, Virginia B Kraus, Farshid Guilak, Louis E DeFrate, Amy L McNulty
PURPOSE: Meniscus tears are a common knee injury and are associated with the development of post-traumatic osteoarthritis (OA). The purpose of this study is to evaluate potential OA mediators in the synovial fluid and serum of meniscus tear subjects compared to those in the synovial fluid of radiographic non-OA control knees. MATERIALS AND METHODS: Sixteen subjects with an isolated unilateral meniscus injury and six subjects who served as reference controls (knee Kellgren-Lawrence grade 0-1) were recruited...
November 4, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27808445/chemokines-and-inflammation-in-osteoarthritis-insights-from-patients-and-animal-models
#18
REVIEW
Carla R Scanzello
Evidence has been building that the pathologic drive for development of osteoarthritis (OA) involves more than simple mechanical "wear and tear." Inflammatory mechanisms play an important role in the tissue response to joint injury, and are involved in development of post-traumatic OA. Inflammation also appears integral to the progression of OA, whether post-traumatic or spontaneous, contributing to the evolution of joint tissue degradation and remodeling as well as joint pain. Both patient-based studies and in vivo models of disease have shed light on a number of inflammatory pathways and mediators that impact various aspects of this disease, both structurally and symptomatically...
November 3, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27796405/-prognostic-assessment-in-private-healthcare-insurance-part-1-risk-of-osteoarthritis
#19
H-T Klemm, A Naumann, G Hofmann, G Spahn
After examining the cause of an accident the medical expert working in the area of private health care insurance under the general accident insurance (AUB) sample conditions must ascertain incapacity within a period of time that has been contractually agreed upon between the parties involved. In addition, this person must also state their position on the question as to whether there may exist any circumstances up to the latest possible point in time in insurance terms that would comprise an adequate prognosis of a future change in the long-term condition...
December 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27778194/intra-articular-injection-of-urinary-bladder-matrix-reduces-osteoarthritis-development
#20
Heather N Jacobs, Sona Rathod, Matthew T Wolf, Jennifer H Elisseeff
Micronized porcine urinary bladder matrix (UBM) is an extracellular matrix biomaterial that has immunomodulatory and pro-regenerative properties. The objective of this study was to assess the ability of UBM to alter disease progression in a mouse model of post-traumatic osteoarthritis (OA). Ten-week-old wild-type C57BL/6 male mice underwent anterior cruciate ligament transection (ACLT) to induce OA. Two weeks after ACLT, UBM (50 mg/mL) or saline was injected into the mouse joint. At 4 and 8 weeks post-ACLT, cartilage integrity was assessed using OARSI scoring of histology, pain was evaluated, and joints were harvested for quantitative RT-PCR analysis of cartilage-specific and inflammatory gene expression...
January 2017: AAPS Journal
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