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Post traumatic osteoarthritis

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https://www.readbyqxmd.com/read/29221903/discrete-element-analysis-is-a-valid-method-for-computing-joint-contact-stress-in-the-hip-before-and-after-acetabular-fracture
#1
Kevin C Townsend, Holly D Thomas-Aitken, M James Rudert, Andrew M Kern, Michael C Willey, Donald D Anderson, Jessica E Goetz
Evaluation of abnormalities in joint contact stress that develop after inaccurate reduction of an acetabular fracture may provide a potential means for predicting the risk of developing post-traumatic osteoarthritis. Discrete element analysis (DEA) is a computational technique for calculating intra-articular contact stress distributions in a fraction of the time required to obtain the same information using the more commonly employed finite element analysis technique. The goal of this work was to validate the accuracy of DEA-computed contact stress against physical measurements of contact stress made in cadaveric hips using Tekscan sensors...
November 16, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29212625/use-of-tricortical-iliac-crest-strut-autograft-in-comminuted-posterior-wall%C3%A2-acetabular-fractures-a-case-series
#2
Sandeep Gupta, Naveen Mittal, Jagandeep Singh Virk
PURPOSE: The results for fixation of comminuted posterior wall acetabular fractures are not very promising with reported complications in terms of osteoarthritis, nonunion and malunion which subsequently require conversion to total hip arthroplasty. The conversion to total hip arthroplasty is possible in patients over 50 years of age but not in younger patients. So this requires new methods for salvage of the native hip in young patients. METHODS: There were six patients in our series with highly comminuted posterior wall acetabular fractures where the fragments were excised and the gap filled with tricortical anterior iliac-crest strut autograft, fixed with screws and plate...
November 6, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29207792/clinical-evaluation-of-efficacy-and-performance-of-all-poly-tibial-freedom%C3%A2-total-knee-system-for-treating-osteoarthritis-patients-three-year-follow-up-study
#3
Avatar Singh, Kanwar Kulwinder Singh
Introduction: Advancement in technology in terms of design and building materials has made Total Knee Replacement (TKR) a highly effective, safe, and predictable orthopedic procedure. Aim: To review the clinical outcomes for efficacy and performance of Freedom Total Knee System for the management of Osteoarthritis (OA), at a minimum of three years follow up. Materials and Methods: For this retrospective, post-marketing study, clinical data of patients treated with Freedom Total Knee System was retrieved from the clinical records after approval from the Institutional Ethics Committee ...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205258/sustained-intra-cartilage-delivery-of-low-dose-dexamethasone-using-a-cationic-carrier-for-treatment-of-post-traumatic-osteoarthritis
#4
A G Bajpayee, R E De la Vega, M Scheu, N H Varady, I A Yannatos, L A Brown, Y Krishnan, T J Fitzsimons, P Bhattacharya, E H Frank, A J Grodzinsky, R M Porter
Disease-modifying osteoarthritis drugs (DMOADs) should reach their intra-tissue target sites at optimal doses for clinical efficacy. The dense, negatively charged matrix of cartilage poses a major hindrance to the transport of potential therapeutics. In this work, electrostatic interactions were utilised to overcome this challenge and enable higher uptake, full-thickness penetration and enhanced retention of dexamethasone (Dex) inside rabbit cartilage. This was accomplished by using the positively charged glycoprotein avidin as nanocarrier, conjugated to Dex by releasable linkers...
December 5, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/29202567/the-use-of-hyaluronic-acid-in-the-treatment-of-ankle-osteoarthritis-a-review-of-the-evidence
#5
R Papalia, E Albo, F Russo, A Tecame, G Torre, S Sterzi, F Bressi, V Denaro
Ankle osteoarthritis (OA) is a progressive degenerative joint disease that causes ankle pain and functional limitation especially during walking. It tends to involve younger people with high functional request and has often a post-traumatic origin. Symptoms control through conservative treatment is essential to procrastinate as long as possible the need for surgery. Although few data are present in literature about the use of local viscosupplementation in ankle OA, their potential use for ankle OA has been suggested...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29191468/malunion-of-post-traumatic-thoracolumbar-fractures
#6
REVIEW
C Mazel, L Ajavon
Thoracolumbar malunion is the result of loss of correction, insufficient correction, or even no correction (both in the frontal and sagittal planes) of a thoracolumbar fracture. The main causes are incorrect assessment of the fracture's complexity (burst fracture), its potential progression to kyphosis, and associated disc or ligament damage. It can also be the result of a poorly conducted initial treatment. The types of malunion have changed over the years because of the introduction of vertebroplasty and kyphoplasty...
November 27, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29189731/differential-effects-of-superoxide-dismutase-mimetics-after-mechanical-overload-of-articular-cartilage
#7
Mitchell C Coleman, Marc J Brouillette, Nicholas S Andresen, Rebecca E Oberley-Deegan, James M Martin
Post-traumatic osteoarthritis can develop as a result of the initial mechanical impact causing the injury and also as a result of chronic changes in mechanical loading of the joint. Aberrant mechanical loading initiates excessive production of reactive oxygen species, oxidative damage, and stress that appears to damage mitochondria in the surviving chondrocytes. To probe the benefits of increasing superoxide removal with small molecular weight superoxide dismutase mimetics under severe loads, we applied both impact and overload injury scenarios to bovine osteochondral explants using characterized mechanical platforms with and without GC4403, MnTE-2-PyP, and MnTnBuOE-2-PyP...
November 30, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29177932/a-computational-algorithm-to-simulate-disorganization-of-collagen-network-in-injured-articular-cartilage
#8
Petri Tanska, Petro Julkunen, Rami K Korhonen
Cartilage defects are a known risk factor for osteoarthritis. Estimation of structural changes in these defects could help us to identify high risk defects and thus to identify patients that are susceptible for the onset and progression of osteoarthritis. Here, we present an algorithm combined with computational modeling to simulate the disorganization of collagen fibril network in injured cartilage. Several potential triggers for collagen disorganization were tested in the algorithm following the assumption that disorganization is dependent on the mechanical stimulus of the tissue...
November 24, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29149841/establishment-of-rat-ankle-post-traumatic-osteoarthritis-model-induced-by-malleolus-fracture
#9
Dawei Liang, Jian Sun, Fangyuan Wei, Jianzhong Zhang, Pengcui Li, Yingke Xu, Xianwen Shang, Jin Deng, Ting Zhao, Lei Wei
BACKGROUND: Malleolar fracture, which is present in 37-53% of human ankle osteoarthritis (OA), is the most common type of fracture in the ankle joint. In spite of this, no rat animal model has been developed for this type of injury to date. Here, we established a rat ankle post-traumatic OA (PTOA) model induced by malleolar fracture; this model will be useful in ankle OA research. METHODS: Two-month-old male Sprague Dawley (SD) rats were randomized into 2 groups (n = 19 per group): 1) malleolus articular fracture, dislocation, and immediate reduction on the right joints and 2) malleolus articular fracture on the right ankle...
November 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29146386/the-risk-of-symptomatic-knee-osteoarthritis-after-arthroscopic-meniscus-repair-vs-partial-meniscectomy-vs-the-general-population
#10
Fredrik Persson, Aleksandra Turkiewicz, Dan Bergkvist, Paul Neuman, Martin Englund
OBJECTIVE: To compare consultation rate for knee osteoarthritis (OA) after meniscus repair, arthroscopic partial meniscectomy (APM), and in general population, respectively. METHOD: We identified patients aged 16-45 years having had meniscus surgery due to traumatic meniscus tear in 1998-2010 in southern Sweden by a healthcare register. Patients were followed from surgery until a diagnosis of knee OA, relocation, death, or December 31(st), 2015. We studied the consultation rate for knee OA compared to the general population...
November 13, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29145965/increased-cytokine-levels-and-histological-changes-in-cartilage-synovial-cells-and-synovial-fluid-after-malleolar-fractures
#11
Alexandre L Godoy-Santos, Lucas Ranzoni, Walcy R Teodoro, Vera Capelozzi, Pedro Giglio, Tulio Diniz Fernandes, Stefan Rammelt
BACKGROUND: Malleolar fractures are among the most common fractures in the human skeleton with a high risk of later development of post-traumatic osteoarthritis (OA). The acute ankle injury initiates a sequence of events potentially leading to progressive articular surface damage resulting from inflammatory changes in cartilage, synovial tissue and synovial fluid. We hypothesised that in the acute phase of ankle fracture, these changes occur at the same time in the different tissues. METHODS: Specimens of chondral tissue, synovial tissue and synovial fluid were collected from 16 patients with acute articular ankle fracture (study group)...
October 2017: Injury
https://www.readbyqxmd.com/read/29111161/effect-of-low-intensity-pulsed-ultrasound-on-joint-injury-and-post-traumatic-osteoarthritis-an-animal-study
#12
Talal Zahoor, Reed Mitchell, Priya Bhasin, Yi Guo, Sharada Paudel, Lew Schon, Zijun Zhang
This study investigated the therapeutic potential of low-intensity pulsed ultrasound (LIPUS) in post-traumatic osteoarthritis (PTOA). Intra-articular fracture of the medial tibial plateau was surgically created in 30 rats. LIPUS was applied to the operated joints either for the first 2 wk (LIPUS1-2 group) or in weeks 4 and 5 after intra-articular fracture (LIPUS4-5 group). In controls, the operated knees were not treated with LIPUS (LIPUS0 group). The rats were monitored with weekly gait analysis and euthanized at week 8...
October 27, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29106758/transcriptomic-analysis-of-synovial-extracellular-rna-following-knee-trauma-a-pilot-study
#13
Anthony J Griswold, Jose Perez, Karen Nuytemans, Thomas Strong, Liyong Wang, Danica D Vance, Hayley Ennis, Marvin K Smith, Thomas M Best, Jeffery M Vance, Margaret A Pericak-Vance, Lee D Kaplan
Traumatic knee injuries often result in damage to articular cartilage and other joint structures. Such trauma is a strong risk factor for the future development and progression of osteoarthritis (OA). The molecular mechanisms and signaling pathways modulating response to knee joint trauma remain unclear. Moreover, investigations of biomarkers influencing responses have been targeted rather than broad, unbiased discovery studies. Herein we characterize the complete complement of extracellular RNA (exRNA) in the synovial fluid of 14 subjects following knee injury...
November 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29103207/complex-tibial-fractures-are-associated-with-lower-social-classes-and-predict-early-exit-from-employment-and-worse-patient-reported-qol-a-prospective-observational-study-of-46-complex-tibial-fractures-treated-with-a-ring-fixator
#14
Rasmus Elsoe, Peter Larsen, Juozas Petruskevicius, Søren Kold
The long-term outcomes following complex fractures of the tibia are reported to carry a risk of knee pain, malalignment, articular injury and post-traumatic osteoarthritis. The main objective of this study was to account for the patient-reported quality of life (QOL) 12 months after ring fixator removal in patients with a complex tibial fracture. Secondary objectives included a review of the socio-economic characteristics of the patient group and the rate of return to work in the study period. A prospective follow-up study was conducted of 60 patients with complex fractures of the tibia treated with ring external fixation...
November 4, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/29100769/arthroscopic-debridement-for-primary-degenerative-osteoarthritis-of-the-elbow-leads-to-significant-improvement-in-range-of-motion-and-clinical-outcomes-a-systematic-review
#15
REVIEW
Kyle R Sochacki, Robert A Jack, Takashi Hirase, Patrick C McCulloch, David M Lintner, Shari R Liberman, Joshua D Harris
PURPOSE: The purpose of this investigation was to determine whether arthroscopic debridement of primary elbow osteoarthritis results in statistically significant and clinically relevant improvement in (1) elbow range of motion and (2) clinical outcomes with (3) low complication and reoperation rates. METHODS: A systematic review was registered with PROSPERO and performed using PRISMA guidelines. Databases were searched for studies that investigated the outcomes of arthroscopic debridement for the treatment of primary osteoarthritis of the elbow in adult human patients...
October 31, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29068480/phlpp-inhibitors-block-pain-and-cartilage-degradation-associated-with-osteoarthritis
#16
Soyun M Hwang, Marina Feigenson, Dana L Begun, Lomeli Carpio Shull, Kirsty L Culley, Miguel Otero, Mary B Goldring, Lauren E Ta, Sanjeev Kakar, Elizabeth W Bradley, Jennifer J Westendorf
Phlpp protein phosphatases are abnormally abundant within human osteoarthritic articular chondrocytes and may contribute to the development of osteoarthritis. Mice lacking Phlpp1 were previously shown to be resistant to post-traumatic osteoarthritis. Here a small molecule with therapeutic properties that inhibits Phlpp1 and Phlpp2 was tested for its ability to slow post-traumatic OA in mice and to stimulate anabolic pathways in human articular cartilage from OA joints. PTOA was induced in male C57Bl/6 mice by surgically destabilizing the meniscus...
October 25, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29062212/early-reduction-of-acetabular-fractures-decreases-the-risk-of-post-traumatic-hip-osteoarthritis
#17
Mario Cahueque, Marcos Martínez, Andrés Cobar, María Bregni
BACKGROUND: Acetabular fractures are complex high-energy injuries. Increasing in recent years with the increased use of high-speed motor vehicles. One of the most important complications of acetabular fracture is the post-traumatic hip osteoarthritis; this complication has been associated to poor fracture reduction, type of fracture and delay in the reduction and fixation of acetabular fracture (Timing surgery). The aims of this study were to determine the incidence of post-traumatic hip osteoarthritis after acetabulum fracture and demonstrate whether the delay surgery is associated to early post-traumatic hip osteoarthritis...
October 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29061493/osteoarthritis-year-in-review-2017-biology
#18
REVIEW
C T Appleton
This Year in Review was derived from a personal selection of articles investigating biological mechanisms of osteoarthritis (OA) and presented at the OARSI World Congress on April 30, 2017. Selected articles were published between the March, 2016 and April, 2017 OARSI meetings. PubMed/MEDLINE searches were performed using the terms "osteoarthritis", "cartilage", "subchondral bone", "synovium", "synovitis", and "ageing". Biomechanical, genetic, genomic, epigenomic, biomarker, clinical, imaging, and tissue engineering studies were excluded since they are covered by other articles in this series...
October 20, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29058227/circulating-levels-of-proinflammatory-mediators-as-potential-biomarkers-of-post-traumatic-knee-osteoarthritis-development
#19
Svetlana B Panina, Igor V Krolevets, Natalia P Milyutina, Alexander B Sagakyants, Igor V Kornienko, Anzhelika A Ananyan, Mikhail A Zabrodin, Andrey A Plotnikov, Valeriy V Vnukov
BACKGROUND: The identification of biomarkers of post-traumatic osteoarthritis (PTOA) progression is of clinical importance. The aims of this study were: (1) to assess the abilities of various soluble proinflammatory mediators in plasma to distinguish patients with knee PTOA from controls; (2) to determine the correlations between the mediators in plasma and those mediators in synovial fluid (SF); and (3) to explore the associations of the mediators with radiographic PTOA severity. MATERIALS AND METHODS: The concentrations of IL-1β, IL-6, IL-18, TNFα, and leptin were measured using ELISA...
October 20, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29038190/effect-of-autologous-adipose-derived-mesenchymal-stem-cell-therapy-in-the-treatment-of-a-post-traumatic-chondral-defect-of-the-knee
#20
Julien Freitag, Douglas Li, James Wickham, Kiran Shah, Abi Tenen
Isolated chondral defects have a limited capacity to heal and predispose to the development of osteoarthritis. Current surgical management can be unpredictable in outcome. Improved understanding of the action of mesenchymal stem cells (MSCs) has seen renewed interest in their role in cartilage repair. A 26-year-old athlete presented with a post-traumatic, isolated patella chondral defect. The patient underwent an arthroscopy with removal of a chondral loose body. After failure to symptomatically improve 12 months following surgery, the patient received intra-articular autologous adipose-derived mesenchymal stem cell (ADMSC) therapy...
October 15, 2017: BMJ Case Reports
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