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https://www.readbyqxmd.com/read/27926932/epsin-family-member-3-and-ribosome-related-genes-are-associated-with-late-metastasis-in-estrogen-receptor-positive-breast-cancer-and-long-term-survival-in-non-small-cell-lung-cancer-using-a-genome-wide-identification-and-validation-strategy
#1
Birte Hellwig, Katrin Madjar, Karolina Edlund, Rosemarie Marchan, Cristina Cadenas, Anne-Sophie Heimes, Katrin Almstedt, Antje Lebrecht, Isabel Sicking, Marco J Battista, Patrick Micke, Marcus Schmidt, Jan G Hengstler, Jörg Rahnenführer
BACKGROUND: In breast cancer, gene signatures that predict the risk of metastasis after surgical tumor resection are mainly indicative of early events. The purpose of this study was to identify genes linked to metastatic recurrence more than three years after surgery. METHODS: Affymetrix HG U133A and Plus 2.0 array datasets with information on metastasis-free, disease-free or overall survival were accessed via public repositories. Time restricted Cox regression models were used to identify genes associated with metastasis during or after the first three years post-surgery (early- and late-type genes)...
2016: PloS One
https://www.readbyqxmd.com/read/27926927/male-circumcision-and-the-epidemic-emergence-of-hiv-2-in-west-africa
#2
João Dinis Sousa, Marina Padrão Temudo, Barry Stephen Hewlett, Ricardo Jorge Camacho, Viktor Müller, Anne-Mieke Vandamme
BACKGROUND: Epidemic HIV-2 (groups A and B) emerged in humans circa 1930-40. Its closest ancestors are SIVsmm infecting sooty mangabeys from southwestern Côte d'Ivoire. The earliest large-scale serological surveys of HIV-2 in West Africa (1985-91) show a patchy spread. Côte d'Ivoire and Guinea-Bissau had the highest prevalence rates by then, and phylogeographical analysis suggests they were the earliest epicenters. Wars and parenteral transmission have been hypothesized to have promoted HIV-2 spread...
2016: PloS One
https://www.readbyqxmd.com/read/27926923/deforestation-impacts-on-bat-functional-diversity-in-tropical-landscapes
#3
Rodrigo García-Morales, Claudia E Moreno, Ernesto I Badano, Iriana Zuria, Jorge Galindo-González, Alberto E Rojas-Martínez, Eva S Ávila-Gómez
Functional diversity is the variability in the functional roles carried out by species within ecosystems. Changes in the environment can affect this component of biodiversity and can, in turn, affect different processes, including some ecosystem services. This study aimed to determine the effect of forest loss on species richness, abundance and functional diversity of Neotropical bats. To this end, we identified six landscapes with increasing loss of forest cover in the Huasteca region of the state of Hidalgo, Mexico...
2016: PloS One
https://www.readbyqxmd.com/read/27926626/frailty-assessed-by-the-forecast-is-a-valid-tool-to-predict-short-term-outcome-after-transcatheter-aortic-valve-replacement
#4
Adrian R Kobe, Alexander Meyer, Hassan Elmubarak, Jörg Kempfert, Jovana Pavicevic, Francesco Maisano, Thomas Walther, Volkmar Falk, Simon H Sündermann
OBJECTIVE: The term frailty is frequently used during decision-making in transcatheter heart valve procedures. Nevertheless, frailty is still measured by eyeballing rather than by using standardized frailty assessments. In a previous study, we developed a frailty score in a cardiac surgical patient population including patients, who underwent transcatheter aortic valve replacement (TAVR). Here, we present the results from the subsequent validation study focusing on the TAVR cohort. METHODS: One hundred thirty patients underwent TAVR...
December 6, 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27926478/bim-deletion-polymorphisms-in-hispanic-patients-with-non-small-cell-lung-cancer-carriers-of-egfr-mutations
#5
Andrés F Cardona, Leonardo Rojas, Beatriz Wills, Oscar Arrieta, Hernán Carranza, Carlos Vargas, Jorge Otero, Luis Corrales-Rodriguez, Claudio Martín, Noemí Reguart, Pilar Archila, July Rodríguez, Mauricio Cuello, Carlos Ortíz, Sandra Franco, Christian Rolfo, Rafael Rosell, On Behalf Of The CLICaP
BACKGROUND: Germline alterations in the proapoptotic protein Bcl-2-like 11 (BIM) can have a crucial role in diverse tumors. To determine the clinical utility of detecting BIM deletion polymorphisms (par4226 bp/ par363 bp) in EGFR positive non-small-cell lung cancer (NSCLC) we examined the outcomes of patients with and without BIM alterations. RESULTS: BIM deletion was present in 14 patients (15.7%). There were no significant differences between patients with and without BIM-del in clinical characteristics or EGFR mutation type; however, those with BIM-del had a worse overall response rate (ORR) to erlotinib (42...
September 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925729/curvature-induced-asymmetric-spin-wave-dispersion
#6
Jorge A Otálora, Ming Yan, Helmut Schultheiss, Riccardo Hertel, Attila Kákay
In magnonics, spin waves are conceived of as electron-charge-free information carriers. Their wave behavior has established them as the key elements to achieve low power consumption, fast operative rates, and good packaging in magnon-based computational technologies. Hence, knowing alternative ways that reveal certain properties of their undulatory motion is an important task. Here, we show using micromagnetic simulations and analytical calculations that spin-wave propagation in ferromagnetic nanotubes is fundamentally different than in thin films...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27925697/prevalence-of-sj%C3%A3-gren-s-syndrome-in-brazilian-patients-infected-with-human-t-cell-lymphotropic-virus
#7
Daniela Assis do Vale, Jorge Casseb, Augusto César Penalva de Oliveira, Ivo Bussoloti Filho, Suzana Cantanhede Orsini Machado de Sousa, Karem López Ortega
BACKGROUND: Human T-lymphotropic virus type I (HTLV-I) is known to be associated with neoplastic and neurodegenerative changes, and it is believed to be associated with various systemic inflammatory diseases, including Sjögren's syndrome (SS). Although HTLV-I infection is endemic in Brazil, there is no information regarding the association between HTLV-I infection and SS in the Brazilian population. The objective of this study was to determine the prevalence of SS in HTLV-I-infected individuals and the prevalence of HTLV-I-infection in individuals diagnosed with SS...
December 7, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27925508/%C3%AE-cyclodextrin-carbon-nanotube-enhanced-sensor-for-ciprofloxacin-detection
#8
Jorge M P J Garrido, Manuel Melle-Franco, Karol Strutyński, Fernanda Borges, Christopher M A Brett, E Manuela P J Garrido
A simple and expedite electrochemical methodology was developed for the determination of ciprofloxacin, based on a glassy carbon (GC) electrode modified by a combination of multi-walled carbon nanotubes (MWCNT) with β-cyclodextrin (β-CD) incorporated in a polyaniline film. The combined use of β-CD and MWCNT in the electrochemical sensor leads to a significant signal improvement. The β-CD/MWCNT modified GC electrode exhibited efficient electrocatalytic behavior in the oxidation of ciprofloxacin with relatively high sensitivity, stability and lifetime...
December 7, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27925291/herbivore-perception-decreases-photosynthetic-carbon-assimilation-and-reduces-stomatal-conductance-by-engaging-12-oxo-phytodienoic-acid-mitogen-activated-protein-kinase-4-and-cytokinin-perception
#9
Ivan D Meza-Canales, Stefan Meldau, Jorge A Zavala, Ian T Baldwin
Herbivory-induced changes in photosynthesis have been documented in many plant species, however the complexity of photosynthetic regulation and analysis has thwarted progress in understanding the mechanism involved, particularly those elicited by herbivore-specific elicitors. Here we analyzed the early photosynthetic gas-exchange responses in Nicotiana attenuata plants after wounding and elicitation with Manduca sexta oral-secretions, and the pathways regulating these responses. Elicitation with M. sexta oral-secretions rapidly decreased photosynthetic carbon-assimilation (AC ) in treated and systemic (untreated, vascularly connected) leaves, which were associated with changes in stomatal conductance, rather than with changes in Rubisco activity and RuBP-turnover...
December 7, 2016: Plant, Cell & Environment
https://www.readbyqxmd.com/read/27925203/the-genetic-landscape-of-breast-carcinomas-with-neuroendocrine-differentiation
#10
Caterina Marchiò, Felipe C Geyer, Charlotte Ky Ng, Salvatore Piscuoglio, Maria R De Filippo, Marco Cupo, Anne M Schultheis, Raymond S Lim, Kathleen A Burke, Elena Guerini-Rocco, Mauro Papotti, Larry Norton, Anna Sapino, Britta Weigelt, Jorge S Reis-Filho
Neuroendocrine breast carcinomas (NBCs) account for 2-5% of all invasive breast cancers and are histologically similar to neuroendocrine tumours from other sites. They typically express oestrogen receptor (ER), are HER2-negative and of luminal subtype. Here we sought to define the mutational profile of NBCs, and to investigate whether NBCs and common forms of luminal (ER+/HER2-) breast cancer display distinct repertoires of somatic mutations. Eighteen ER+/HER2- NBCs, defined as harbouring >50% of tumour cells expressing chromogranin A and/or synaptophysin, and matched normal tissue were microdissected and subjected to massively parallel sequencing targeting all exons of 254 genes most frequently mutated in breast cancer and/or related to DNA repair...
December 7, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27925120/factors-associated-with-the-use-of-motorcycle-helmets-in-two-colombian-cities
#11
Jorge Martín Rodríguez Hernández, Fredy Armindo Camelo Tovar, Liany Katerine Ariza Ruiz
The aim of this study was to identify the prevalence and some characteristics associated with the use of motorcycle helmets in two Colombian cities. The researcher used quantitative and qualitative techniques. The prevalence of the use of a motorcycle helmet among motorcyclists was greater in Ibague (98.1%) than in Valledupar (82.4%); among passengers in the city of Valledupar, it did not reach 2%. Men were 2.1 times more likely to wear helmets than women (IC 95:1.6-2.7). Using qualitative techniques, the factors explaining the reasons for use/non-use of helmets (being hygienic, climatic, esthetic and safety reasons) were identified for Valledupar...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27924808/avian-h11-influenza-virus-isolated-from-domestic-poultry-in-a-colombian-live-animal-market
#12
Pedro Jiménez-Bluhm, Erik A Karlsson, Karl A Ciuoderis, Valerie Cortez, Shauna A Marvin, Christopher Hamilton-West, Stacey Schultz-Cherry, Jorge E Osorio
Live animal markets (LAMs) are an essential source of food and trade in Latin American countries; however, they can also serve as 'hotbeds' for the emergence and potential spillover of avian influenza viruses (AIV). Despite extensive knowledge of AIV in Asian LAMs, little is known about the prevalence South American LAMs. To fill this gap in knowledge, active surveillance was carried out at the major LAM in Medellin, Colombia between February and September 2015. During this period, overall prevalence in the market was 2...
December 7, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27924379/relationship-between-pelvic-floor-muscle-strength-and-sexual-dysfunction-in-postmenopausal-women-a-cross-sectional-study
#13
Maíra de Menezes Franco, Patricia Driusso, Kari Bø, Daniela Cristina Carvalho de Abreu, Lucia Alves da Silva Lara, Ana Carolina Japur de Sá Rosa E Silva, Cristine Homsi Jorge Ferreira
INTRODUCTION AND HYPOTHESIS: The prevalence of sexual dysfunction in postmenopausal women is high. Theoretically pelvic floor muscle (PFM) strength could influence sexual function, but to date there is scant evidence on this topic. The aim of this study was to evaluate the relationship between PFM strength and sexual function in postmenopausal women. The relationship between reported urinary incontinence (UI) and sexual dysfunction was also investigated. METHODS: This was a cross-sectional study including 113 postmenopausal women...
December 6, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27923989/metabolic-control-of-tobacco-pollination-by-sugars-and-invertases
#14
Marc Goetz, Anne Guivarc'h, Jörg Hirsche, Martin Andreas Bauerfeind, María-Cruz González, Tae Kyung Hyun, Seung Hee Eom, Dominique Chriqui, Thomas Engelke, Dominik K Großkinsky, Thomas Roitsch
Pollination in flowering plants is initiated by germination of pollen grains on stigmas followed by fast growth of pollen tubes representing highly energy-consuming processes. The symplastic isolation of pollen grains and tubes requires import of sucrose available in the apoplast. We show that the functional coupling of sucrose cleavage by invertases and uptake of the released hexoses by monosaccharide transporters are critical for pollination in tobacco. Transcript profiling, in situ hybridization and immunolocalization of extracellular invertases and two monosaccharide transporters in vitro and in vivo support the functional coupling in supplying carbohydrates for pollen germination and tube growth evidenced by spatiotemporally coordinated expression...
December 6, 2016: Plant Physiology
https://www.readbyqxmd.com/read/27923464/news-in-multiple-sclerosis-remyelination-as-a-therapeutic-target
#15
Jorge Matías-Guiu, Ulises Gomez-Pinedo, Jordi A Matias-Guiu
No abstract text is available yet for this article.
December 3, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27923345/combined-transcriptome-and-metabolome-analyses-to-understand-the-dynamic-responses-of-rice-plants-to-attack-by-the-rice-stem-borer-chilo-suppressalis-lepidoptera-crambidae
#16
Qingsong Liu, Xingyun Wang, Vered Tzin, Jörg Romeis, Yufa Peng, Yunhe Li
BACKGROUND: Rice (Oryza sativa L.), which is a staple food for more than half of the world's population, is frequently attacked by herbivorous insects, including the rice stem borer, Chilo suppressalis. C. suppressalis substantially reduces rice yields in temperate regions of Asia, but little is known about how rice plants defend themselves against this herbivore at molecular and biochemical level. RESULTS: In the current study, we combined next-generation RNA sequencing and metabolomics techniques to investigate the changes in gene expression and in metabolic processes in rice plants that had been continuously fed by C...
December 7, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/27923324/uncovering-the-in-vivo-source-of-adult-neural-crest-stem-cells
#17
Jorge B Aquino
Some late embryonic and adult postmigratory neural crest-derived cells (NCDCs) from diverse tissues were shown to grow as multipotent neurospheres. Neural crest stem cells (NCSCs) contained in these spheres, were found to give rise not only to neuroectodermal derivatives but also to some of the progeny of the other embryonic germ layers. In this review, evidences regarding the in vivo properties of NCDCs contributing to NCSCs are discussed. Even though in many cases the final prove for the phenotype identity of in vivo cells generating NCSCs is lacking, some evidences suggest that such postmigratory NCDCs would differ from neural crest cells (NCCs)...
December 6, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27923231/congenital-absence-of-the-pericardium-a-systematic-approach-to-diagnosis-and-management
#18
Bo Xu, Jorge Betancor, Craig Asher, Adriana Rosario, Allan Klein
Congenital absence of the pericardium (CAP) is a rare condition. Failure to recognize the clinical features of this condition can lead to incorrect and delayed diagnosis. Limited data are available regarding the optimal approach to diagnose and manage patients with suspected CAP. Due to the rare nature of CAP, this condition can present diagnostic and management dilemmas for clinicians. Using 3 cases of CAP as a framework, a clinically focused review on the diagnosis and management of CAP is presented. Clinicians will be provided with a systematic approach to evaluating patients with suspected CAP, incorporating key history, examination, and multimodality cardiovascular imaging investigations...
December 7, 2016: Cardiology
https://www.readbyqxmd.com/read/27923227/optimal-role-of-the-nephrologist-in-the-intensive-care-unit
#19
D J Askenazi, Michael Heung, Michael J Connor, Rajit K Basu, Jorge Cerdá, Kent Doi, Jay L Koyner, Azra Bihorac, Ladan Golestaneh, Anitha Vijayan, Mark D Okusa, Sarah Faubel
As advances in Critical Care Medicine continue, critically ill patients are surviving despite the severity of their illness. The incidence of acute kidney injury (AKI) has increased, and its impact on clinical outcomes as well as medical expenditures has been established. The role, indications and technological advancements of renal replacement therapy (RRT) have evolved, allowing more effective therapies with less complications. With these changes, Critical Care Nephrology has become an established specialty, and ongoing collaborations between critical care physicians and nephrologist have improved education of multi-disciplinary team members and patient care in the ICU...
December 3, 2016: Blood Purification
https://www.readbyqxmd.com/read/27922951/anatomic-and-ultrasonographic-evaluation-of-the-knee-sensory-innervation-a-cadaveric-study-to-determine-anatomic-targets-in-the-treatment-of-chronic-knee-pain
#20
Jorge M Orduña Valls, Ricardo Vallejo, Pablo López Pais, Eliezer Soto, Daniel Torres Rodríguez, David L Cedeño, Carlos Tornero Tornero, Maximino Quintáns Rodríguez, Aurora Baluja González, Julián Álvarez Escudero
BACKGROUND AND OBJECTIVES: Osteoarthrosis is a main cause of knee pain in the elderly. Pain associated with this condition is often refractory to conservative treatment. Total knee replacement may be the best option for severe pathologies; however, the occurrence of a chronic pain state after knee replacement has been well documented in the literature. The previous descriptions of the genicular nerves have been considered somewhat inaccurate. This innervation is complex and exhibits significant interindividual variability...
December 5, 2016: Regional Anesthesia and Pain Medicine
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