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https://www.readbyqxmd.com/read/28918546/systemic-effects-of-repeated-intraocular-dexamethasone-intravitreal-implant-in-diabetic-patients-a-retrospective-study
#1
Alicia Valverde-Megías, Pilar Cifuentes-Canorea, Jorge Ruiz-Medrano, Pablo Peña-García, Alicia Megías-Fresno, Juan Donate-López, Julián García-Feijoo
INTRODUCTION: The objective of this study is to evaluate the influence of repeated intraocular dexamethasone implant (Ozurdex) injections on metabolic control in type 2 diabetic patients. METHODS: Retrospective study of 165 type 2 diabetic patients starting Ozurdex treatment who received no less than three consecutive injections. Glycated hemoglobin (HbA1c), serum creatinine, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides (TGs) were evaluated during 15 months of follow-up after Ozurdex treatment onset...
September 16, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28918435/infant-avoidance-training-alters-cellular-activation-patterns-in-prefronto-limbic-circuits-during-adult-avoidance-learning-ii-cellular-imaging-of-neurons-expressing-the-activity-regulated-cytoskeleton-associated-protein-arc-arg3-1
#2
Nicole Gröger, Anja Mannewitz, Jörg Bock, Susann Becker, Katja Guttmann, Gerd Poeggel, Katharina Braun
Positive and negative feedback learning is essential to optimize behavioral performance. We used the two-way active avoidance (TWA) task as an experimental paradigm for negative feedback learning with the aim to test the hypothesis that neuronal ensembles activate the activity-regulated cytoskeletal (Arc/Arg3.1) protein during different phases of avoidance learning and during retrieval. A variety of studies in humans and other animals revealed that the ability of aversive feedback learning emerges postnatally...
September 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28918304/haploidentical-transplantation-for-older-patients-with-acute-myeloid-leukemia-and-myelodysplastic-syndrome
#3
Stefan O Ciurea, Mithun V Shah, Rima M Saliba, Sameh Gaballa, Piyanuch Kongtim, Gabriela Rondon, Julianne Chen, Whitney Wallis, Kai Cao, Marina Konopleva, Naval Daver, Jorge Cortes, Farhad Ravandi, Amin Alousi, Sairah Ahmed, Uday Popat, Simrit Parmar, Qaiser Bashir, Oran Betul, Chitra Hosing, Elizabeth J Shpall, Katayoun Rezvani, Issa F Khouri, Partow Kebriaei, Richard E Champlin
Allogeneic stem cell transplant (ASCT) with HLA matched donors is increasingly used for older patients with AML/MDS. It remains unclear if haploidentical transplantation (haploSCT) is a suitable option for older patients with this disease. We analyzed 43 patients with AML/MDS (median age 61 years) who underwent a haploSCT at our institution. All the patients received a fludarabine-melphalan-based reduced-intensity conditioning regimen and post-transplant cyclophosphamide-based GVHD prophylaxis. Except one patient who had early death, the remaining 42 patients (98%) engrafted donor cells...
September 13, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28918132/assessing-precision-bias-and-sigma-metrics-of-53-measurands-of-the-alinity-ci-system
#4
Sten Westgard, Victoria Petrides, Sharon Schneider, Marvin Berman, Jörg Herzogenrath, Anthony Orzechowski
Assay performance is dependent on the accuracy and precision of a given method. These attributes can be combined into an analytical Sigma-metric, providing a simple value for laboratorians to use in evaluating a test method's capability to meet its analytical quality requirements. Sigma-metrics were determined for 37 clinical chemistry assays, 13 immunoassays, and 3 ICT methods on the Alinity ci system. METHODS: Analytical Performance Specifications were defined for the assays, following a rationale of using CLIA goals first, then Ricos Desirable goals when CLIA did not regular the method, and then other sources if the Ricos Desirable goal was unrealistic...
September 13, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28917870/ultra-high-pressure-modified-cellulosic-fibres-with-antimicrobial-properties
#5
Ana M Salgueiro, Mauro D Santos, Jorge A Saraiva, Filipe Almeida, Isabel Sousa, João Tedim, Helena I S Nogueira, Dmitry V Evtuguin
In this work bleached E. globulus kraft pulp was doped with polyhexamethylene biguanide (PHMB) from an aqueous solution or from a suspension of silica capsules (PHMB@silica) by impregnation under atmospheric or ultra-high pressure (UHP) conditions (500MPa). The antimicrobial properties of pulps were evaluated towards gram-negative E. coli and gram-positive L. innocua bacteria. PHMB loads below 500mg per kg of pulp revealed negligible bacteriostatic properties, whereas PHMB loads of ca 3000-4000mg per kg demonstrated bactericidal properties of pulp without significant deterioration of its mechanical strength...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917804/development-and-validation-of-a-maleimide-based-enzyme-linked-immunosorbent-assay-for-the-detection-of-tetrodotoxin-in-oysters-and-mussels
#6
Laia Reverté, Maria Rambla-Alegre, Sandra Leonardo, Carlos Bellés, Katrina Campbell, Christopher T Elliott, Arjen Gerssen, Mirjam D Klijnstra, Jorge Diogène, Mònica Campàs
The recent detection of tetrodotoxins (TTXs) in puffer fish and shellfish in Europe highlights the necessity to monitor the levels of TTXs in seafood by rapid, specific, sensitive and reliable methods in order to protect human consumers. A previous immunoassay for TTX detection in puffer fish, based on the use of self-assembled monolayers (SAMs) for the immobilization of TTX on maleimide plates (mELISA), has been modified and adapted to the analysis of oyster and mussel samples. Changing dithiol for cysteamine-based SAMs enabled reductions in the assay time and cost, while maintaining the sensitivity of the assay...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917464/the-majority-of-patients-presenting-with-vitiligo-have-a-clinical-sign-of-activity
#7
Nader Aboul-Fettouh, Jorge Hinojosa, Andrea Tovar-Garza, Amit G Pandya
No abstract text is available yet for this article.
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28917287/intraoperative-computed-tomography-in-cranial-neurosurgery
#8
REVIEW
Christian Schichor, Nicole Terpolilli, Jun Thorsteinsdottir, Jörg-Christian Tonn
The challenge for treating complex lesions with the aim of minimal surgery-related morbidity has generated an increasing demand for sophisticated intraoperative imaging modalities. Newest generations of intraoperative computed tomography (CT) scanners offer a multitude of hardware and software improvements resulting in higher image quality that further propagates its everyday usage in the interdisciplinary operative setting. This article describes workflow and applicability of intraoperative CT scanning in cranial neurosurgery, in subspecialties like skull base or vascular neurosurgery, and its advantages and limitations...
October 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/28916960/a-novel-approach-using-the-enhanced-view-totally-extraperitoneal-etep-technique-for-laparoscopic-retromuscular-hernia-repair
#9
Igor Belyansky, Jorge Daes, Victor Gheorghe Radu, Ramana Balasubramanian, H Reza Zahiri, Adam S Weltz, Udai S Sibia, Adrian Park, Yuri Novitsky
BACKGROUND: The enhanced-view totally extraperitoneal (eTEP) technique has been previously described for Laparoscopic Inguinal Hernia Repair. We present a novel application of the eTEP access technique for the repair of ventral and incisional hernias. METHODS: Retrospective review of consecutive laparoscopic retromuscular hernia repair cases utilizing the eTEP access approach from five hernia centers between August 2015 and October 2016 was conducted. Patient demographics, hernia characteristics, operative details, perioperative complications, and quality of life outcomes utilizing the Carolina's Comfort Scale (CCS) were included in our data analysis...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28916807/envelope-glycoprotein-mobility-on-hiv-1-particles-depends-on-the-virus-maturation-state
#10
Jakub Chojnacki, Dominic Waithe, Pablo Carravilla, Nerea Huarte, Silvia Galiani, Jörg Enderlein, Christian Eggeling
Human immunodeficiency virus type 1 (HIV-1) assembles as immature particles, which require the proteolytic cleavage of structural polyprotein Gag and the clustering of envelope glycoprotein Env for infectivity. The details of mechanisms underlying Env clustering remain unknown. Here, we determine molecular dynamics of Env on the surface of individual HIV-1 particles using scanning fluorescence correlation spectroscopy on a super-resolution STED microscope. We find that Env undergoes a maturation-induced increase in mobility, highlighting diffusion as one cause for Env clustering...
September 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28916789/whole-body-and-hematopoietic-adam8-deficiency-does-not-influence-advanced-atherosclerotic-lesion-development-despite-its-association-with-human-plaque-progression
#11
Kosta Theodorou, Emiel P C van der Vorst, Marion J Gijbels, Ine M J Wolfs, Mike Jeurissen, Thomas L Theelen, Judith C Sluimer, Erwin Wijnands, Jack P Cleutjens, Yu Li, Yvonne Jansen, Christian Weber, Andreas Ludwig, Jacob F Bentzon, Jörg W Bartsch, Erik A L Biessen, Marjo M P C Donners
Although A Disintegrin And Metalloproteinase 8 (ADAM8) is not crucial for tissue development and homeostasis, it has been implicated in various inflammatory diseases by regulating processes like immune cell recruitment and activation. ADAM8 expression has been associated with human atherosclerosis development and myocardial infarction, however a causal role of ADAM8 in atherosclerosis has not been investigated thus far. In this study, we examined the expression of ADAM8 in early and progressed human atherosclerotic lesions, in which ADAM8 was significantly upregulated in vulnerable lesions...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916716/deregulation-of-microrna-expression-in-purified-t-and-b-lymphocytes-from-patients-with-primary-sj%C3%A3-gren-s-syndrome
#12
Shu-Fang Wang-Renault, Saida Boudaoud, Gaétane Nocturne, Elodie Roche, Nelly Sigrist, Christian Daviaud, Andreas Bugge Tinggaard, Victor Renault, Jean-François Deleuze, Xavier Mariette, Jörg Tost
OBJECTIVE: MicroRNAs (miRNAs) play an important role in the pathogenesis of autoimmune diseases such as primary Sjögren's syndrome (pSS). This study is the first to investigate miRNA expression patterns in purified T and B lymphocytes from patients with pSS using a high-throughput quantitative PCR (qPCR) approach. METHODS: Two independent cohorts of both patients with pSS and controls, one for discovery and one for replication, were included in this study. CD4+ T cells and CD19+ B cells were isolated from peripheral blood mononuclear cells by magnetic microbeads and expression of miRNAs was profiled using the Exiqon Human miRNome panel I analysing 372 miRNAs...
September 15, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28916584/novel-insights-into-the-clinical-phenotype-and-pathophysiology-underlying-low-vwf-levels
#13
Michelle Lavin, Sonia Aguila, Sonja Schneppenheim, Niall Dalton, Kenneth L Jones, Jamie M O'Sullivan, Niamh M O'Connell, Kevin Ryan, Barry White, Mary Byrne, Marie Rafferty, Mairead M Doyle, Margaret Nolan, Roger J S Preston, Ulrich Budde, Paula James, Jorge Di Paola, James S O'Donnell
Critical clinical questions remain unanswered regarding diagnosis and management of patients with Low VWF levels (30-50 IU/dL). To address these questions, the Low VWF Ireland Cohort (LoVIC) study investigated 126 patients registered with Low VWF. Interestingly, despite their marginally reduced plasma VWF levels, ISTH BAT and Condensed MCMDM-1 VWD scores both confirmed significant bleeding phenotypes in the majority of LoVIC patients. For example, among female patients with Low VWF, 77% had ISTH BAT scores ≥6...
September 15, 2017: Blood
https://www.readbyqxmd.com/read/28916444/treating-malaria-new-drugs-for-a-new-era
#14
G Dennis Shanks, Jörg J Möhrle
No abstract text is available yet for this article.
September 12, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28916427/simultaneous-detection-and-differentiation-of-three-potyviridae-viruses-in-sweet-potato-by-a-multiplex-taqman-real-time-rt-pcr-assay
#15
Pingxiu Lan, Fan Li, Jorge Abad, Lingling Pu, Ruhui Li
A multiplex TaqMan real time RT-PCR was developed for detection and differentiation of Sweet potato virus G, Sweet potato latent virus and Sweet potato mild mottle virus in one tube. Amplification and detection of a fluorogenic cytochrome oxidase gene was included as an internal control. The assay was compared with a multiplex RT-PCR developed in the initial study for the detection and differentiation of the three viruses and host 18S rRNA. Primers and/or probes of the two assays were designed from conserved regions of each virus...
September 12, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28916324/in%C3%A2-vitro-investigation-of-the-antimicrobial-effect-of-three-bisphosphonates-against-different-bacterial-strains
#16
Michael A Ermer, Simon C Kottmann, Jörg-Elard Otten, Annette Wittmer, Philipp Poxleitner, Klaus Pelz
PURPOSE: Since the first descriptions of medication-related osteonecrosis of the jaw (MRONJ) in 2003, the pathogenesis has remained unanswered. Recent histomorphometric studies have found several microorganisms, including Actinomyces, Bacillus, Fusobacterium, Staphylococcus, Streptococcus, Selenomonas, Treponema, and Candida albicans in necrotic bone. Polymerase chain reaction studies have recently confirmed the occurrence of 48 genera. Only a few studies have examined the antimicrobial effect of bisphosphonates (BPs)...
August 31, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28916046/inflammatory-response-and-long-term-behavioral-assessment-after-neonatal-co2-pneumothorax-study-in-a-rodent-model
#17
Alice Miranda, Susana Roque, Cláudia Serre-Miranda, José Miguel Pêgo, Jorge Correia-Pinto
BACKGROUND: Carbon-dioxide (CO2)-pneumothorax during minimally invasive surgery induces well-known metabolic changes. However, little is known about its impact on the central nervous system. The aim of this work is to evaluate the acute impact of CO2-pneumothorax over central cytokine response and its long-term effect on animal behavior. METHODS: This is an experimental study where neonatal Sprague-Dawley rats are submitted to CO2-pneumothorax. Peripheral and central cytokine response was evaluated 24h after insufflation, and peripheral immune cell phenotyping was evaluated 24h and 4weeks post-insufflation...
August 24, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28915947/immunosensor-array-platforms-based-on-self-assembled-dithiols-for-the-electrochemical-detection-of-tetrodotoxins-in-puffer-fish
#18
Laia Reverté, Katrina Campbell, Maria Rambla-Alegre, Christopher T Elliott, Jorge Diogène, Mònica Campàs
The recent detection of tetrodotoxins (TTXs) in European fish and shellfish has emphasized the urgent need to develop specific, selective, rapid and easy-to-use methods for their detection to assess the potential risk posed to human health. For this purpose, a dithiol self-assembled monolayer (SAM)-based immunoassay previously performed on maleimide plates (mELISA) has been adapted to gold electrode arrays for the development of an electrochemical immunosensor for TTX. The electrochemical SAM-based immunosensor designed herein, provided an oriented, stable and spaced sensing platform for the determination of TTX, attaining a limit of detection of 2...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915869/frequency-and-genotypes-of-chlamydia-trachomatis-in-patients-attending-the-obstetrics-and-gynecology-clinics-in-jalisco-mexico-and-correlation-with-sociodemographic-behavioral-and-biological-factors
#19
Néstor Casillas-Vega, Rayo Morfín-Otero, Santos García, Jorge Llaca-Díaz, Eduardo Rodríguez-Noriega, Adrián Camacho-Ortiz, Ma de la Merced Ayala-Castellanos, Héctor J Maldonado-Garza, Jesús Ancer-Rodríguez, Guadalupe Gallegos-Ávila, Alberto Niderhauser-García, Elvira Garza-González
BACKGROUND: Chlamydia trachomatis is the causative agent of the most common bacterial sexually transmitted infection worldwide. The aim of this study was to investigate the frequency and genotypes of C. trachomatis in patients attending an obstetrics and gynecology clinic in Jalisco, Mexico and correlates them with sociodemographic, behavioral, and biological factors. METHODS: C. trachomatis detection was performed in endocervical samples from 662 patients by direct fluorescence assay (DFA) and two PCR assays that amplified the phospholipase D endonuclease superfamily protein (PLDESP) and OmpA genes...
September 15, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28915523/-biologic-reconstruction-of-full-sized-cartilage-defects-of-the-hip-a-guideline-from-the-dgou-group-clinical-tissue-regeneration-and-the-hip-committee-of-the-aga
#20
Stefan Fickert, Matthias Aurich, Dirk Albrecht, Peter Angele, Lorenz Büchler, Michael Dienst, Christoph Erggelet, Jürgen Fritz, Christoph Gebhart, Hans Gollwitzer, Moritz Kindler, Christoph Lampert, Henning Madry, Gregor Möckel, Phillip Niemeyer, Jörg Schröder, Christian Sobau, Gunter Spahn, Wolfgang Zinser, Stefan Landgraeber
Background Symptomatic pre-arthritic deformities such as femoroacetabular impingement (FAI) or hip dysplasia often lead to localised cartilage defects and subsequently to osteoarthritis. The present review of the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU) and the hip committee of the AGA (German speaking Society for Arthroscopy and Joint Surgery) provides an overview of current knowledge of the diagnosis and surgical treatment of cartilage defects, in order to infer appropriate therapy recommendations for the hip...
September 15, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
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