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https://www.readbyqxmd.com/read/28431450/-livestock-associated-methicillin-resistant-staphylococcus-aureus-epidemiological-data-from-an-orthopaedic-department-in-north-west-germany
#1
Gerrit Steffen Maier, Fritz Thorey, Kristina Kolbow, Djordje Lazovic, Markus Lühmann, Jörg Ohnsorge, Uwe Maus
Background MRSA represents a considerable health threat to orthopaedic patients. Throughout the last decade, livestock-associated MRSA emerged increasingly in livestock all over Europe. LA-MRSA broke the species barrier, colonizing and causing infections in humans. Nevertheless, to date there are no studies concerning livestock-associated MRSA and orthopaedic patients. Therefore, we aimed to investigate the prevalence of LA-MRSA in a regional orthopaedic department localized in an area with high-density livestock...
April 21, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28431247/the-ubiquitin-ligase-chip-integrates-proteostasis-and-aging-by-regulation-of-insulin-receptor-turnover
#2
Riga Tawo, Wojciech Pokrzywa, Éva Kevei, Melek E Akyuz, Vishnu Balaji, Svenja Adrian, Jörg Höhfeld, Thorsten Hoppe
Aging is attended by a progressive decline in protein homeostasis (proteostasis), aggravating the risk for protein aggregation diseases. To understand the coordination between proteome imbalance and longevity, we addressed the mechanistic role of the quality-control ubiquitin ligase CHIP, which is a key regulator of proteostasis. We observed that CHIP deficiency leads to increased levels of the insulin receptor (INSR) and reduced lifespan of worms and flies. The membrane-bound INSR regulates the insulin and IGF1 signaling (IIS) pathway and thereby defines metabolism and aging...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28431006/regulation-of-oxidized-platelet-lipidome-implications-for-coronary-artery-disease
#3
Madhumita Chatterjee, Dominik Rath, Jörg Schlotterbeck, Johannes Rheinlaender, Britta Walker-Allgaier, Nada Alnaggar, Monika Zdanyte, Iris Müller, Oliver Borst, Tobias Geisler, Tilman E Schäffer, Michael Lämmerhofer, Meinrad Gawaz
Aims: Hyperlipidaemia enhances susceptibility to thrombosis, while platelet oxidixed LDL (oxLDL) binding in acute coronary syndrome (ACS) correlates with activation status. This study explores the platelet lipidome in symptomatic coronary artery disease (CAD) patients and the functional consequences of the chemokine CXCL12 and its receptors CXCR-4/-7 on lipid uptake in platelets. Methods and results: Platelet-oxLDL detected by flow cytometry was enhanced (P = 0...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28429845/following-nature-s-roadmap-folding-factors-from-plasma-cells-led-to-improvements-in-antibody-secretion-in-s-cerevisiae
#4
Essi V Koskela, Jorg C de Ruijter, Alexander D Frey
Therapeutic protein production in yeast is a reality in industry with an untapped potential to expand to more complex proteins, such as full-length antibodies. Despite multiple numerous engineering approaches, cellular limitations are preventing the use of Saccharomyces cerevisiae as the titers of recombinant antibodies are currently not competitive. Instead of a host specific approach, we demonstrate the possibility of adopting the features from native producers of antibodies, plasma cells, to improve antibody production in yeast...
April 21, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28429744/a-forest-of-sub-1-5-nm-wide-single-walled-carbon-nanotubes-over-an-engineered-alumina-support
#5
Ning Yang, Meng Li, Jörg Patscheider, Seul Ki Youn, Hyung Gyu Park
A precise control of the dimension of carbon nanotubes (CNTs) in their vertical array could enable many promising applications in various fields. Here, we demonstrate the growth of vertically aligned, single-walled CNTs (VA-SWCNTs) with diameters in the sub-1.5-nm range (0.98 ± 0.24 nm), by engineering a catalyst support layer of alumina via thermal annealing followed by ion beam treatment. We find out that the ion beam bombardment on the alumina allows the growth of ultra-narrow nanotubes, whereas the thermal annealing promotes the vertical alignment at the expense of enlarged diameters; in an optimal combination, these two effects can cooperate to produce the ultra-narrow VA-SWCNTs...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429319/biochemistry-and-physiology-of-heavy-metal-resistance-and-accumulation-in-euglena
#6
Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez, Ricardo Jasso-Chávez, Emma Saavedra, Jorge D García-García
Free-living microorganisms may become suitable models for removal of heavy metals from polluted water bodies, sediments, and soils by using and enhancing their metal accumulating abilities. The available research data indicate that protists of the genus Euglena are a highly promising group of microorganisms to be used in bio-remediation of heavy metal-polluted aerobic and anaerobic acidic aquatic environments. This chapter analyzes the variety of biochemical mechanisms evolved in E. gracilis to resist, accumulate and remove heavy metals from the environment, being the most relevant those involving (1) adsorption to the external cell pellicle; (2) intracellular binding by glutathione and glutathione polymers, and their further compartmentalization as heavy metal-complexes into chloroplasts and mitochondria; (3) polyphosphate biosynthesis; and (4) secretion of organic acids...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28429194/photobiomodulation-therapy-associated-with-treadmill-training-in-the-oxidative-stress-in-a-collagen-induced-arthritis-model
#7
Solange Almeida Dos Santos, Marcia Ataize Dos Santos Vieira, Maira Cécilia Brandão Simões, Andrey Jorge Serra, Ernesto Cesar Leal-Junior, Paulo de Tarso Camillo de Carvalho
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by chronic and systemic inflammation, which leads to the destruction of the cartilage and bone and affects tissues in multiple joints. Oxidative stress has been implicated with regards to involvement in various disease conditions, such as diabetes mellitus and neurodegenerative, respiratory, cardiovascular, and RA diseases. In vivo experimental studies using photobiomodulation therapy (PBMT) have shown positive effects in reducing lipid peroxidation and in increasing antioxidant activity...
April 21, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28429178/sleep-habits-fatigue-and-sleepiness-in-chiclayo-peru-s-bus-drivers
#8
Fátima Deza-Becerra, Jorge Rey de Castro, Carol Gonzales-Gonzales, Franco Ernesto León-Jiménez, Jorge Osada-Liy, Edmundo Rosales-Mayor
OBJECTIVE: The objectives of the study are to describe sleep habits, fatigue, and sleepiness in Chiclayo's (Peru) bus drivers and explore their relation with traffic accidents. MATERIAL AND METHODS: This is a descriptive cross-sectional study with a non-probability consecutive sampling. The sample size was 126 drivers. Sleepiness was evaluated using the Epworth Sleepiness Scale and sleep hygiene with validated questionnaires. We used a history of traffic accident or a near-traffic accident as an independent variable and applied chi-squared, t, and Mann-Whitney U tests to evaluate initial associations, which were later tested with a multivariate analysis...
April 21, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28428873/a-maize-landrace-that-emits-defense-volatiles-in-response-to%C3%A2-herbivore-eggs-possesses-a-strongly-inducible-terpene-synthase-gene
#9
Amanuel Tamiru, Toby J A Bruce, Annett Richter, Christine M Woodcock, Charles A O Midega, Jörg Degenhardt, Segenet Kelemu, John A Pickett, Zeyaur R Khan
Maize (Zea mays) emits volatile terpenes in response to insect feeding and egg deposition to defend itself against harmful pests. However, maize cultivars differ strongly in their ability to produce the defense signal. To further understand the agroecological role and underlying genetic mechanisms for variation in terpene emission among maize cultivars, we studied the production of an important signaling component (E)-caryophyllene in a South American maize landrace Braz1006 possessing stemborer Chilo partellus egg inducible defense trait, in comparison with the European maize line Delprim and North American inbred line B73...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28428767/social-cognitive-training-improves-emotional-processing-and-reduces-aggressive-attitudes-in-ex-combatants
#10
Sandra Trujillo, Natalia Trujillo, Jose D Lopez, Diana Gomez, Stella Valencia, Jorge Rendon, David A Pineda, Mario A Parra
Emotional processing (EP) is a complex cognitive function necessary to successfully adjust to social environments where we need to interpret and respond to cues that convey threat or reward signals. Ex-combatants have consistently shown atypical EP as well as poor social interactions. Available reintegration programs aim to facilitate the re-adaptation of ex-combatants to their communities. However, they do not incorporate actions to improve EP and to enhance cognitive-emotional regulation. The present study was aimed at evaluating the usefulness of an intervention focused on Social Cognitive Training (SCT), which was designed to equip ex-combatants enrolled in the Social Reintegration Route with EP and social cognition skills...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28428356/biological-variation-estimates-obtained-from-91-healthy-study-participants-for-9-enzymes-in-serum
#11
Anna Carobene, Thomas Røraas, Una Ørvim Sølvik, Marit Sverresdotter Sylte, Sverre Sandberg, Elena Guerra, Irene Marino, Niels Jonker, Gerhard Barla, William A Bartlett, Pilar Fernandez-Calle, Jorge Díaz-Garzón, Francesca Tosato, Mario Plebani, Abdurrahman Coŝkun, Mustafa Serteser, Ibrahim Unsal, Ferruccio Ceriotti
BACKGROUND: We sought to develop estimates of biological variation (BV) for 9 enzymes in blood serum as part of the European Biological Variation Study. METHODS: Ninety-one healthy study participants (38 male and 53 female, 21-69 years old) were phlebotomized in each of 10 consecutive weeks at 6 European laboratories. The same preanalytical sample-handling protocol was followed at each center before transport to San Raffaele Hospital, Milan, Italy, for analysis...
April 20, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28428018/visual-analytics-dashboard-to-explore-the-relationship-of-unscheduled-treatment-interruptions-and-variations-in-airway-management-for-children-undergoing-external-beam-radiation-therapy
#12
Pandora Chua, Christine Hill-Kayser, Luis M Ahumada, Ali Jalal, Allan F Simpao, Arul M Lingappan, Abbas Jawad, Mohamed A Rehman, Jorge A Gálvez
No abstract text is available yet for this article.
January 20, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28427866/effect-of-amyloid-%C3%AE-25-35-in-hyperglycemic-and-hyperinsulinemic-rats-effects-on-phosphorylation-and-o-glcnacylation-of-tau-protein
#13
Liliana Lozano, Jorge Guevara, Tony Lefebvre, Ivan Ramos-Martinez, Daniel Limón, Alfonso Díaz, Eduarda Cerón, Edgar Zenteno
Aggregation of the amyloid beta (Aβ) peptide and hyperphosphorylation of tau protein, which are markers of Alzheimer's disease (AD), have been reported also in diabetes mellitus (DM). One regulator of tau phosphorylation is O-GlcNAcylation, whereas for hyperphosphorylation it could be GSK3beta, which is activated in hyperglycemic conditions. With this in mind, both O-GlcNAcylation and phosphorylation of tau protein were evaluated in the brain of rats with streptozotocin (STZ)-induced hyperglycemia and hyperinsulinemia and treated with the Aß25-35 peptide in the hippocampal region CA1...
April 6, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28427790/exercise-and-ckd-skeletal-muscle-dysfunction-and-practical-application-of-exercise-to-prevent-and-treat-physical-impairments-in-ckd
#14
Baback Roshanravan, Jorge Gamboa, Kenneth Wilund
Patients with chronic kidney disease experience substantial loss of muscle mass, weakness, and poor physical performance. As kidney disease progresses, skeletal muscle dysfunction forms a common pathway for mobility limitation, loss of functional independence, and vulnerability to disease complications. Screening for those at high risk for mobility disability by self-reported and objective measures of function is an essential first step in developing an interdisciplinary approach to treatment that includes rehabilitative therapies and counseling on physical activity...
April 18, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28427657/tube-reactors-as-a-novel-ultrasonication-system-for-trouble-free-treatment-of-sludges
#15
Konrad Koch, Thomas Lippert, Natalia Hauck Sabadini, Jörg E Drewes
The performance of a novel low-maintenance tube reactor for ultrasonic treatment of sludge has been evaluated. The effects of sonication on the release of soluble chemical oxygen demand (sCOD) and anaerobic digestibility of raw and digested sewage sludge as well as agricultural sludge were studied. Results suggest that solubilization and digestibility is dependent on both type of sludge and the energy input. Digested and raw sludge showed high degree of solubilization, however, methane production was only increased for digested sludge...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427649/hydrodynamic-cavitation-in-combination-with-the-ozone-hydrogen-peroxide-and-the-uv-based-advanced-oxidation-processes-for-the-removal-of-natural-organic-matter-from-drinking-water
#16
Matej Čehovin, Alojz Medic, Jens Scheideler, Jörg Mielcke, Achim Ried, Boris Kompare, Andreja Žgajnar Gotvajn
Natural organic matter in drinking water is causing concern especially due to the formation of disinfection by-products (DBPs) by chlorine, as these are proven to have adverse health effects on consumers. In this research, humic acid was used as a source of dissolved organic carbon (DOC) in drinking water (up to 3mgL(-1)). The efficiency of DOC removal was studied by applying O3, H2O2/O3, H2O2/UV and O3/UV advanced oxidation processes (AOPs) alone and combined with hybrid hydrodynamic cavitation (HC), generated by an orifice plate, as this technology recently shows promising potential for the treatment of water, containing recalcitrant organic substances...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427533/influence-of-high-hydrostatic-pressure-technology-on-wine-chemical-and-sensorial-characteristics-potentialities-and-drawbacks
#17
Cláudia Nunes, Mickael C Santos, Jorge A Saraiva, Sílvia M Rocha, Manuel A Coimbra
During last years, scientific research on high hydrostatic pressure (HHP) as a nonthermal processing technology for preservation or aging of wine has increased substantially. HHP between 200 and 500MPa is able to inactivate bacteria and yeasts in red and white wines, suggesting that it may be used for wine preservation. However, these treatments have been shown to promote changes on sensorial and physicochemical characteristics in both red and white wines, not immediately in the first month, but along storage...
2017: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/28427506/recent-advances-in-genitourinary-tumors-a-review-focused-on-biology-and-systemic-treatment
#18
REVIEW
Aránzazu González Del Alba, José Ángel Arranz, Javier Puente, María José Méndez-Vidal, Enrique Gallardo, Enrique Grande, Begoña Pérez-Valderrama, Enrique González-Billalabeitia, Martín Lázaro-Quintela, Álvaro Pinto, Nuria Lainez, Josep M Piulats, Emilio Esteban, José Pablo Maroto Rey, Jorge A García, Cristina Suárez
Updated information published up to 2016 regarding major advances in renal cancer, bladder cancer, and prostate cancer is here presented. Based on an ever better understanding of the genetic and molecular alterations that govern the initial pathogenic mechanisms of tumor oncogenesis, an improvement in the characterization and treatment of urologic tumors has been achieved in the past year. According to the Cancer Genome Atlas (ATLAS) project, alterations in the MET pathway are characteristics of type 1 papillary renal cell carcinomas, and activation of NRF2-ARE pathway is associated with the biologically distinct type 2...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28427292/chemical-analyses-and-in-vitro-and-in-vivo-toxicity-of-fruit-methanol-extract-of-sechium-edule-var-nigrum-spinosum
#19
Itzen Aguiñiga-Sánchez, Jorge Cadena-Íñiguez, Edelmiro Santiago-Osorio, Guadalupe Gómez-García, Víctor Manuel Mendoza-Núñez, Juana Rosado-Pérez, Mirna Ruíz-Ramos, Víctor Manuel Cisneros-Solano, Edgar Ledesma-Martínez, Angel de Jesus Delgado-Bordonave, Ramón Marcos Soto-Hernández
CONTEXT: Sechium edule (Jacq.) Sw. (Cucurbitaceae) is used in ethnomedicine, but the diversity of the varietal groups of this species has not often been considered. This is important because we previously reported that different variety of species exhibit different activities across different tumor cell lines. OBJECTIVE: This study investigates the chemical composition and biological activities of extracts obtained from S. edule var. nigrum spinosum. MATERIALS AND METHODS: The leukemia P388 cell line and mononuclear bone marrow cells (MNCBMs) were treated with the extract at a concentration ranging from 40 to 2370 μg/mL for cytotoxicity and viability assays...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28427150/senoptosis-non-lethal-dna-cleavage-as-a-route-to-deep-senescence
#20
Maja Studencka, Jörg Schaber
DNA-damage-induced apoptosis and cellular senescence are perceived as two distinct cell fates. We found that after ionizing radiation (IR)-induced DNA damage the majority (up to 70 %) of senescent human diploid fibroblasts (HDFs) were subjected to controlled cleavage of DNA, resulting in the establishment of a viable and stable sub-G1 population, i.e. deeply senescent cells. We show that in senescent HDFs this DNA cleavage is triggered by modest loss of the mitochondrial membrane potential, which is not sufficient to activate caspases, but strong enough to release mitochondrial endonuclease G (EndoG)...
February 25, 2017: Oncotarget
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