keyword
https://read.qxmd.com/read/38456228/lncrna-lucat1-promotes-glioblastoma-progression-by-enhancing-hif1%C3%AE-activity
#21
JOURNAL ARTICLE
Haidong Huang, Hariti Shah, Jing Hao, Jianhong Lin, Richard A Prayson, Liangqi Xie, Shideng Bao, Abhishek A Chakraborty, Eckhard Jankowsky, Jianjun Zhao, Jennifer S Yu
BACKGROUND: Hypoxia is associated with poor prognosis in many cancers including glioblastoma (GBM). Glioma stem-like cells (GSCs) often reside in hypoxic regions and serve as reservoirs for disease progression. Long non-coding RNAs (lncRNAs) have been implicated in GBM. However, the lncRNAs that modulate GSC adaptations to hypoxia are poorly understood. Identification of these lncRNAs may provide new therapeutic strategies to target GSCs under hypoxia. METHODS: lncRNAs induced by hypoxia in GSCs were identified by RNAseq...
March 8, 2024: Neuro-oncology
https://read.qxmd.com/read/38452695/effectively-%C3%AE-terpineol-suppresses-glioblastoma-aggressive-behavior-and-downregulates-kdelc2-expression
#22
JOURNAL ARTICLE
Jong-Shiaw Jin, Jung-Mao Chou, Wen-Chiuan Tsai, Ying-Chuan Chen, Ying Chen, Jiann-Ruey Ong, Yu-Ling Tsai
BACKGROUND: Glioblastoma (GBM) is notorious for the aggressive behaviors and easily results in chemo-resistance. Studies have shown that the use of herbal medicines as treatments for GBM as limited by the blood-brain barrier (BBB) and glioma stem cells. PURPOSE: The aim of this study was to investigate the relationship between GBM suppression and α-terpineol, the monoterpenoid alcohol derived from Eucalyptus glubulus and Pinus merkusii. STUDY DESIGN: Using serial in-vitro and in-vivo studies to confirm the mechanism of α-terpineol on down-regulating GBM development...
February 23, 2024: Phytomedicine
https://read.qxmd.com/read/38438773/cdkn2a-promoter-methylation-enhances-self-renewal-of-glioblastoma-stem-cells-and-confers-resistance-to-carmustine
#23
JOURNAL ARTICLE
Jing Wang, Yan-Feng Xi, Qi Zhao, Jiang-Hong Guo, Zhen Zhang, Mao-Bai Zhang, Jiang Chang, Yue-Qin Wu, Wen Su
BACKGROUND: Glioblastoma, a highly aggressive form of brain cancer, poses significant challenges due to its resistance to therapy and high recurrence rates. This study aimed to investigate the expression and functional implications of CDKN2A, a key tumor suppressor gene, in glioblastoma cells, building upon the existing background of knowledge in this field. METHOD: Quantitative reverse transcription PCR (qRT-PCR) analysis was performed to evaluate CDKN2A expression in U87 glioblastoma cells compared to normal human astrocytes (NHA)...
March 5, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38438091/fpr1-a-critical-gatekeeper-of-the-heart-and-brain
#24
REVIEW
Ziyin Zhangsun, Yushu Dong, Jiayou Tang, Zhenxiao Jin, Wangrui Lei, Changyu Wang, Ying Cheng, Baoying Wang, Yang Yang, Huadong Zhao
G protein-coupled receptors (GPCRs) are currently the most widely focused drug targets in the clinic, exerting their biological functions by binding to chemicals and activating a series of intracellular signaling pathways. Formyl-peptide receptor 1 (FPR1) has a typical seven-transmembrane structure of GPCRs and can be stimulated by a large number of endogenous or exogenous ligands with different chemical properties, the first of which was identified as formyl-methionine-leucyl-phenylalanine (fMLF). Through receptor-ligand interactions, FPR1 is involved in inflammatory response, immune cell recruitment, and cellular signaling regulation in key cell types, including neutrophils, neural stem cells (NSCs), and microglia...
March 2, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38431436/intratumoral-il-12-delivery-via-mesenchymal-stem-cells-combined-with-pd-1-blockade-leads-to-long-term-antitumor-immunity-in-a-mouse-glioblastoma-model
#25
JOURNAL ARTICLE
Junseong Park, Soon A Park, Yoon-Seob Kim, Dokyeong Kim, Sun Shin, Sug Hyung Lee, Sin-Soo Jeun, Yeun-Jun Chung, Stephen Ahn
BACKGROUND: Although PD-1 blockade is effective for treating several types of cancer, the efficacy of this agent in glioblastoma is largely limited. To overcome non-responders and the immunosuppressive tumor microenvironment, combinational immunotherapeutic strategies with anti-PD-1 need to be considered. Here, we developed IL-12-secreting mesenchymal stem cells (MSC_IL-12) with glioblastoma tropism and evaluated the therapeutic effects of anti-PD-1, MSC_IL-12, and their combination against glioblastoma...
November 6, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38425276/mesenchymal-stem-cells-reduce-long-term-cognitive-deficits-and-attenuate-myelin-disintegration-and-microglia-activation-following-repetitive-traumatic-brain-injury
#26
JOURNAL ARTICLE
Lan-Wan Wang, Chung-Ching Chio, Chien-Ming Chao, Pi-Yu Chao, Mao-Tsun Lin, Ching-Ping Chang, Hung-Jung Lin
The underlying mechanisms for the beneficial effects exerted by bone marrow-mesenchymal stem cells (BM-MSCs) in treating repetitive traumatic brain injury (rTBI)-induced long-term sensorimotor/cognitive impairments are not fully elucidated. Herein, we aimed to explore whether BM-MSCs therapy protects against rTBI-induced long-term neurobehavioral disorders in rats via normalizing white matter integrity and gray matter microglial response. Rats were subjected to repeated mild lateral fluid percussion on day 0 and day 3...
2024: Science Progress
https://read.qxmd.com/read/38419943/mir-128-3p%C3%A2-a-gray-eminence-of-the-human-central-nervous-system
#27
REVIEW
Klaudia Kiel, Sylwia Katarzyna Król, Agnieszka Bronisz, Jakub Godlewski
MicroRNA-128-3p (miR-128-3p) is a versatile molecule with multiple functions in the physiopathology of the human central nervous system. Perturbations of miR-128-3p, which is enriched in the brain, contribute to a plethora of neurodegenerative disorders, brain injuries, and malignancies, as this miRNA is a crucial regulator of gene expression in the brain, playing an essential role in the maintenance and function of cells stemming from neuronal lineage. However, the differential expression of miR-128-3p in pathologies underscores the importance of the balance between its high and low levels...
March 12, 2024: Molecular Therapy. Nucleic Acids
https://read.qxmd.com/read/38418476/creb5-promotes-the-proliferation-and-self-renewal-ability-of-glioma-stem-cells
#28
JOURNAL ARTICLE
Hyun-Jin Kim, Hye-Min Jeon, Don Carlo Batara, Seongsoo Lee, Suk Jun Lee, Jinlong Yin, Sang-Ik Park, Minha Park, Jong Bae Seo, Jinik Hwang, Young Joon Oh, Sung-Suk Suh, Sung-Hak Kim
Glioblastoma multiforme (GBM) is the most fatal form of brain cancer in humans, with a dismal prognosis and a median overall survival rate of less than 15 months upon diagnosis. Glioma stem cells (GSCs), have recently been identified as key contributors in both tumor initiation and therapeutic resistance in GBM. Both public dataset analysis and direct differentiation experiments on GSCs have demonstrated that CREB5 is more highly expressed in undifferentiated GSCs than in differentiated GSCs. Additionally, gene silencing by short hairpin RNA (shRNA) of CREB5 has prevented the proliferation and self-renewal ability of GSCs in vitro and decreased their tumor forming ability in vivo...
February 28, 2024: Cell Death Discovery
https://read.qxmd.com/read/38417064/lymphatic-endothelial-like-cells-in-the-glioblastoma-tumor-niche-drive-metabolic-alterations-that-promote-stem-cell-proliferation-and-survival
#29
JOURNAL ARTICLE
Reilly L Kidwell, Manish K Aghi
No abstract text is available yet for this article.
February 28, 2024: Neuro-oncology
https://read.qxmd.com/read/38413460/deep-learning-glioma-grading-with-the-tumor-microenvironment-analysis-protocol-for-comprehensive-learning-discovering-and-quantifying-microenvironmental-features
#30
JOURNAL ARTICLE
M Pytlarz, K Wojnicki, P Pilanc, B Kaminska, A Crimi
Gliomas are primary brain tumors that arise from neural stem cells, or glial precursors. Diagnosis of glioma is based on histological evaluation of pathological cell features and molecular markers. Gliomas are infiltrated by myeloid cells that accumulate preferentially in malignant tumors, and their abundance inversely correlates with survival, which is of interest for cancer immunotherapies. To avoid time-consuming and laborious manual examination of images, a deep learning approach for automatic multiclass classification of tumor grades was proposed...
February 27, 2024: J Imaging Inform Med
https://read.qxmd.com/read/38405180/bulk-rna-sequencing-reveals-the-comprehensive-genetic-characteristics-of-human-cord-blood-derived-natural-killer-cells
#31
JOURNAL ARTICLE
Takayuki Morimoto, Tsutomu Nakazawa, Ryosuke Maeoka, Ryosuke Matsuda, Mitsutoshi Nakamura, Fumihiko Nishimura, Shuichi Yamada, Ichiro Nakagawa, Young-Soo Park, Takahiro Tsujimura
INTRODUCTION: Innate immune cells are important in tumor immunotherapy. Natural killer cells (NKCs) are also categorized as innate immune cells and can control tumor growth and metastatic spread. Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. NKC-based immunotherapy is a promising treatment strategy against GBM. We previously reported a feeder-free expansion system that yielded large-scale highly purified and cytotoxic NKCs derived from human cord blood (CB)...
March 2024: Regenerative Therapy
https://read.qxmd.com/read/38404687/pbx1-a-tale-of-two-seasons-key-roles-during-development-and-in-cancer
#32
REVIEW
Laura Crisafulli, Matteo Brindisi, Mirko Giuseppe Liturri, Cristina Sobacchi, Francesca Ficara
Pre-B cell leukemia factor 1 (PBX1) is a Three Aminoacid Loop Extension (TALE) homeodomain-containing transcription factor playing crucial roles in organ pattering during embryogenesis, through the formation of nuclear complexes with other TALE class and/or homeobox proteins to regulate target genes. Its contribution to the development of several organs has been elucidated mainly through the study of murine knockout models. A crucial role for human development has been recently highlighted through the discovery of different de novo pathogenic PBX1 variants in children affected by developmental defects...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38398118/m-6-a-mrna-modifications-in-glioblastoma-emerging-prognostic-biomarkers-and-therapeutic-targets
#33
REVIEW
Gloria S Xie, Hope T Richard
Glioblastoma, the most common and aggressive primary brain tumor, is highly invasive and neurologically destructive. The mean survival for glioblastoma patients is approximately 15 months and there is no effective therapy to significantly increase survival times to date. The development of effective therapy including mechanism-based therapies is urgently needed. At a molecular biology level, N6-methyladenine (m6 A) mRNA modification is the most abundant posttranscriptional RNA modification in mammals. Recent studies have shown that m6 A mRNA modifications affect cell survival, cell proliferation, invasion, and immune evasion of glioblastoma...
February 9, 2024: Cancers
https://read.qxmd.com/read/38396925/lysine-methylation-dependent-proteolysis-by-the-malignant-brain-tumor-mbt-domain-proteins
#34
REVIEW
Hong Sun, Hui Zhang
Lysine methylation is a major post-translational protein modification that occurs in both histones and non-histone proteins. Emerging studies show that the methylated lysine residues in non-histone proteins provide a proteolytic signal for ubiquitin-dependent proteolysis. The SET7 (SETD7) methyltransferase specifically transfers a methyl group from S-Adenosyl methionine to a specific lysine residue located in a methylation degron motif of a protein substrate to mark the methylated protein for ubiquitin-dependent proteolysis...
February 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38396911/involvement-of-mitochondria-in-the-selective-response-to-microsecond-pulsed-electric-fields-on-healthy-and-cancer-stem-cells-in-the-brain
#35
JOURNAL ARTICLE
Arianna Casciati, Anna Rita Taddei, Elena Rampazzo, Luca Persano, Giampietro Viola, Alice Cani, Silvia Bresolin, Vincenzo Cesi, Francesca Antonelli, Mariateresa Mancuso, Caterina Merla, Mirella Tanori
In the last few years, pulsed electric fields have emerged as promising clinical tools for tumor treatments. This study highlights the distinct impact of a specific pulsed electric field protocol, PEF-5 (0.3 MV/m, 40 μs, 5 pulses), on astrocytes (NHA) and medulloblastoma (D283) and glioblastoma (U87 NS) cancer stem-like cells (CSCs). We pursued this goal by performing ultrastructural analyses corroborated by molecular/omics approaches to understand the vulnerability or resistance mechanisms triggered by PEF-5 exposure in the different cell types...
February 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38394444/cancer-stem-cell-hypothesis-2-0-in-glioblastoma-where-are-we-now-and-where-are-we-going
#36
JOURNAL ARTICLE
Anthony R Sloan, Daniel J Silver, Sam Kint, Marco Gallo, Justin D Lathia
Over the past 2 decades, the cancer stem cell (CSC) hypothesis has provided insight into many malignant tumors, including glioblastoma (GBM). Cancer stem cells have been identified in patient-derived tumors and in some mouse models, allowing for a deeper understanding of cellular and molecular mechanisms underlying GBM growth and therapeutic resistance. The CSC hypothesis has been the cornerstone of cellular heterogeneity, providing a conceptual and technical framework to explain this longstanding phenotype in GBM...
February 23, 2024: Neuro-oncology
https://read.qxmd.com/read/38393450/effects-of-bone-marrow-mesenchymal-stem-cell-derived-exosomes-in-central-nervous-system-diseases
#37
REVIEW
Miao Chai, Gang Su, Wei Chen, Juan Gao, Qionghui Wu, Jinyang Song, Zhenchang Zhang
Central nervous system (CNS) diseases are one of the diseases that threaten human health. The delivery of drugs targeting the CNS has always been a significant challenge; the blood-brain barrier (BBB) is the main obstacle that must be overcome. The rise of bone marrow mesenchymal stem cell (BMSC) therapy has brought hope for the treatment of CNS diseases. However, the problems of low homing rate, susceptibility differentiation into astrocytes, immune rejection, and formation of iatrogenic tumors of transplanted BMSCs limit their clinical application...
February 23, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38392188/-oct4-expression-in-gliomas-is-dependent-on-cell-metabolism
#38
JOURNAL ARTICLE
Andrey Volnitskiy, Konstantin Shabalin, Rimma Pantina, Elena Varfolomeeva, Roman Kovalev, Vladimir Burdakov, Svetlana Emelianova, Luiza Garaeva, Alexander Yakimov, Marina Sogoyan, Michael Filatov, Andrey L Konevega, Tatiana Shtam
The OCT4 transcription factor is necessary to maintain cell stemness in the early stages of embryogenesis and is involved in the formation of induced pluripotent stem cells, but its role in oncogenesis is not yet entirely clear. In this work, OCT4 expression was investigated in malignant gliomas. Twenty glioma cell lines and a sample of normal adult brain tissue were used. OCT4 expression was found in all studied glioma cell lines but was not detected in normal adult brain tissue. For one of these lines, OCT4 knockdown caused tumor cell death...
January 25, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38383496/smarca4-loss-and-mutated-%C3%AE-catenin-induce-proliferative-lesions-in-the-murine-embryonic-cerebellum
#39
JOURNAL ARTICLE
Carolin Göbel, Melanie Schoof, Dörthe Holdhof, Michael Spohn, Ulrich Schüller
Almost all medulloblastomas (MB) of the Wingless/Int-1 (WNT) type are characterized by hotspot mutations in CTNNB1, and mouse models have convincingly demonstrated the tumor-initiating role of these mutations. Additional alterations in SMARCA4 are detected in around 20% of WNT MB, but their functional role is mostly unknown. We therefore amended previously described Blbp-cre::Ctnnb1(ex3)fl/wt mice by the introduction of floxed Smarca4 alleles. Unexpectedly, mutated and thereby stabilized β-catenin on its own induced severe developmental phenotypes in male and female Blbp-cre::Ctnnb1(ex3)fl/wt mice in our hands, including a thinned cerebral cortex, hydrocephalus, missing cerebellar layering, and cell accumulations in the brain stem and cerebellum...
February 21, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38377560/discovery-of-novel-n-anthracen-9-ylmethyl-benzamide-derivatives-as-znf207-inhibitors-promising-in-treating-glioma
#40
JOURNAL ARTICLE
Menghan Zhang, Yushi Ding, Mengkang Gao, Xiaolin Lu, Jun Tan, Fei Yu, Congying Gu, Lujun Gu, Xiameng Ren, Chenyan Hao, Liqin Ming, Kang Xu, Wenhao Mao, Yuqing Jin, Min Zhang, Linjun You, Zhanbo Wang, Yuanyuan Sun, Jingwei Jiang, Yong Yang, Dayong Zhang, Xinying Tang
Targeting tumor stemness is an innovative approach to cancer treatment. Zinc Finger Protein 207 (ZNF207) is a promising target for weakening the stemness of glioma cells. Here, a series of novel N -(anthracen-9-ylmethyl) benzamide derivatives against ZNF207 were rationally designed and synthesized. The inhibitory activity was evaluated, and their structure-activity relationships were summarized. Among them, C16 exhibited the most potent inhibitory activity, as evidenced by its IC50 values ranging from 0.5-2...
February 20, 2024: Journal of Medicinal Chemistry
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