Martin M Jendryka, Uwe Lewin, Bastiaan van der Veen, Sampath K T Kapanaiah, Vivien Prex, Daniel Strahnen, Thomas Akam, Birgit Liss, Anton Pekcec, Wiebke Nissen, Dennis Kätzel
The anterior cingulate cortex (ACC) has been implicated in attention deficit hyperactivity disorder (ADHD). More specifically, an appropriate balance of excitatory and inhibitory activity in the ACC may be critical for the control of impulsivity, hyperactivity, and sustained attention which are centrally affected in ADHD. Hence, pharmacological augmentation of parvalbumin- (PV) or somatostatin-positive (Sst) inhibitory ACC interneurons could be a potential treatment strategy. We, therefore, tested whether stimulation of Gq -protein-coupled receptors (Gq PCRs) in these interneurons could improve attention or impulsivity assessed with the 5-choice-serial reaction-time task in male mice...
July 5, 2023: Translational Psychiatry