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https://www.readbyqxmd.com/read/28739248/the-protective-effect-of-hydrogen-sulfide-h2s-on-traumatic-brain-injury-tbi-induced-memory-deficits-in-rats
#1
Seyed Asaad Karimi, Narges Hosseinmardi, Mahyar Janahmadi, Mohammad Sayyah, Razieh Hajisoltani
Traumatic brain injury (TBI), as an expanding public health epidemic, is a common cause of death among youth. TBI is associated with cognitive deficits and memory impairment. Hydrogen sulfide (H2S), a novel gaseous mediator, has been recognized as an important neuromodulator and neuroprotective agent in the central nervous system. In the present study the potential neuroprotective role of sodium hydrosulfide (NaHS), an H2S donor on TBI induced memory deficit in a rat model of controlled cortical impact (CCI) injury was investigated...
July 21, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28738059/predicting-diabetes-mellitus-using-smote-and-ensemble-machine-learning-approach-the-henry-ford-exercise-testing-fit-project
#2
Manal Alghamdi, Mouaz Al-Mallah, Steven Keteyian, Clinton Brawner, Jonathan Ehrman, Sherif Sakr
Machine learning is becoming a popular and important approach in the field of medical research. In this study, we investigate the relative performance of various machine learning methods such as Decision Tree, Naïve Bayes, Logistic Regression, Logistic Model Tree and Random Forests for predicting incident diabetes using medical records of cardiorespiratory fitness. In addition, we apply different techniques to uncover potential predictors of diabetes. This FIT project study used data of 32,555 patients who are free of any known coronary artery disease or heart failure who underwent clinician-referred exercise treadmill stress testing at Henry Ford Health Systems between 1991 and 2009 and had a complete 5-year follow-up...
2017: PloS One
https://www.readbyqxmd.com/read/28733273/whatsapp-messenger-as-an-adjunctive-tool-for-telemedicine-an-overview
#3
Vincenzo Giordano, Hilton Koch, Alexandre Godoy-Santos, William Dias Belangero, Robinson Esteves Santos Pires, Pedro Labronici
BACKGROUND: The advent of telemedicine has allowed physicians to deliver medical treatment to patients from a distance. Mobile apps such as WhatsApp Messenger, an instant messaging service, came as a novel concept in all fields of social life, including medicine. The use of instant messaging services has been shown to improve communication within medical teams by providing means for quick teleconsultation, information sharing, and starting treatment as soon as possible. OBJECTIVE: The aim of this study was to perform a comprehensive systematic review of present literature on the use of the WhatsApp Messenger app as an adjunctive health care tool for medical doctors...
July 21, 2017: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/28731306/historical-view-on-lead-guidelines-and-regulations
#4
Hana R Pohl, Susan Z Ingber, Henry G Abadin
Lead has been used in many commodities for centuries. As a result, human exposure has occurred through the production and use of these lead-containing products. For example, leaded gasoline, lead-based paint, and lead solder/pipes in water distribution systems have been important in terms of exposure potential to the general population. Worker exposures occur in various industrial activities such as lead smelting and refining, battery manufacturing, steel welding or cutting operations, printing, and construction...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28731294/the-bioinorganic-chemistry-of-lead-in-the-context-of-its-toxicity
#5
Wolfgang Maret
Owing to its abundance on earth and its multiple uses by humans, lead (Pb) is a major toxicant that has threatened human health for millennia and continues to do so. There is no safe level of exposure, necessitating a nuanced approach to its control in the food we consume, the water we drink, and the air we breathe. Turnover in soft tissues is within days. In contrast, lead accumulates in bone and turns over with a half-life of about 30 years, though it can be mobilized from bone under physiological and pathophysiological conditions of bone resorption...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28730825/the-implication-of-ampa-receptor-in-synaptic-plasticity-impairment-and-intellectual-disability-in-fragile-x-syndrome
#6
G-R Cheng, X-Y Li, Y-D Xiang, D Liu, S M McClintock, Y Zeng
Fragile X syndrome (FXS) is the most frequently inherited form of intellectual disability and prevalent single-gene cause of autism. A priority of FXS research is to determine the molecular mechanisms underlying the cognitive and social functioning impairments in humans and the FXS mouse model. Glutamate ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors (AMPARs) mediate a majority of fast excitatory neurotransmission in the central nervous system and are critically important for nearly all aspects of brain function, including neuronal development, synaptic plasticity, and learning and memory...
July 18, 2017: Physiological Research
https://www.readbyqxmd.com/read/28730508/quality-improvement-initiatives-in-inflammatory-bowel-disease
#7
REVIEW
Sameer K Berry, Corey A Siegel, Gil Y Melmed
PURPOSE OF REVIEW: This article serves as an overview of several quality improvement initiatives in inflammatory bowel disease (IBD). RECENT FINDINGS: IBD is associated with significant variation in care, suggesting poor quality of care. There have been several efforts to improve the quality of care for patients with IBD. Quality improvement (QI) initiatives in IBD are intended to be patient-centric, improve outcomes for individuals and populations, and reduce costs-all consistent with "the triple aim" put forth by the Institute for Healthcare Improvement (IHI)...
August 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28729710/learning-a-health-knowledge-graph-from-electronic-medical-records
#8
Maya Rotmensch, Yoni Halpern, Abdulhakim Tlimat, Steven Horng, David Sontag
Demand for clinical decision support systems in medicine and self-diagnostic symptom checkers has substantially increased in recent years. Existing platforms rely on knowledge bases manually compiled through a labor-intensive process or automatically derived using simple pairwise statistics. This study explored an automated process to learn high quality knowledge bases linking diseases and symptoms directly from electronic medical records. Medical concepts were extracted from 273,174 de-identified patient records and maximum likelihood estimation of three probabilistic models was used to automatically construct knowledge graphs: logistic regression, naive Bayes classifier and a Bayesian network using noisy OR gates...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729234/mobile-phone-supported-physiotherapy-for-frozen-shoulder-feasibility-assessment-based-on-a-usability-study
#9
Thomas Stütz, Gerlinde Emsenhuber, Daniela Huber, Michael Domhardt, Martin Tiefengrabner, Gertie Janneke Oostingh, Ulrike Fötschl, Nicholas Matis, Simon Ginzinger
BACKGROUND: Patients with frozen shoulder show limited shoulder mobility often accompanied by pain. Common treatment methods include physiotherapy, pain medication, administration of corticosteroids, and surgical capsulotomy. Frozen shoulder often lasts from months to years and mostly affects persons in the age group of 40 to 70 years. It severely reduces the quality of life and the ability to work. OBJECTIVE: The objective of this study was to evaluate the feasibility of a mobile health (mHealth) intervention that supports patients affected by "stage two" frozen shoulder...
July 20, 2017: JMIR Rehabil Assist Technol
https://www.readbyqxmd.com/read/28727640/no-seasonal-changes-in-cognitive-functioning-among-high-school-football-athletes-implementation-of-a-novel-electrophysiological-measure-and-standard-clinical-measures
#10
Steven P Broglio, Richelle Williams, Ashley Rettmann, Brandon Moore, James T Eckner, Sean Meehan
OBJECTIVE: To evaluate neuroelectric and cognitive function relative to a season of football participation. Cognitive and neuroelectric function declines are hypothesized to be present in football athletes. DESIGN: Observational. SETTING: Athletic fields and research laboratory. PATIENTS (OR PARTICIPANTS): Seventy-seven high school athletes (15.9 + 0.9 years, 178.6 + 7.2 cm, 74.4 + 14.7 kg, and 0.8 + 0.8 self-reported concussions) participating in football (n = 46) and noncontact sports (n = 31)...
July 14, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28727546/a-formative-evaluation-of-a-diabetes-prevention-program-using-the-re-aim-framework-in-a-learning-health-care-system-utah-2013-2015
#11
Kimberly D Brunisholz, Jaewhan Kim, Lucy A Savitz, Mia Hashibe, Lisa H Gren, Sharon Hamilton, Kelly Huynh, Elizabeth A Joy
INTRODUCTION: Evaluation of interventions can help to close the gap between research and practice but seldom takes place during implementation. Using the RE-AIM framework, we conducted a formative evaluation of the first year of the Intermountain Healthcare Diabetes Prevention Program (DPP). METHODS: Adult patients who met the criteria for prediabetes (HbA1c of 5.70%-6.49% or fasting plasma glucose of 100-125 mg/dL) were attributed to a primary care provider from August 1, 2013, through July 31, 2014...
July 20, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28726269/previous-physical-exercise-alters-hepatic-profile-of-oxidative-inflammatory-status-and-limits-the-secondary-brain-damage-induced-by-severe-tbi-in-rats
#12
Mauro Robson Torres de Castro, Ana Paula de Oliveira Ferreira, Guilherme Lago Busanello, Luís Roberto Hart da Silva, Mauro Eduardo Porto da Silveira Junior, Fernando Fiorin, Gabriela Arrifano, Maria Elena Crespo López, Rômulo Pillon Barcelos, María J Cuevas, Guilherme Bresciani, Javier González-Gallego, Michele Rechia Fighera, Luiz Fernando Freire Royes
Although systemic responses have been described after traumatic brain injury (TBI), little is known regarding potential interactions between brain and peripheral organs after neuronal injury. In this sense, we decided to investigate whether peripheral oxidative/inflammatory response contributes to the neuronal dysfunction after TBI as well as prophylactic role of exercise training. Animals were submitted to fluid percussion injury (FPI) after 6 weeks of swimming training. Previous exercise training increased mRNA expression of X receptor alpha (LXR-α), ATP-binding cassette transporter (ABCA1), and decreased inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α) and interleukin (IL)-6 expression per se in liver...
July 20, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28725785/pathology-course-director-perspectives-of-a-recent-lcme-experience-preparation-in-an-integrated-curriculum-with-the-revised-standards
#13
Barbara E C Knollmann-Ritschel, Eric Suarez, William Gilliland, Richard Conran, Arnyce Pock
Preparation for a Liaison Committee of Medical Education (LCME) accreditation site visit is a daunting task for any medical school, particularly for medical schools that have adopted integrated curricula. The LCME accreditation is the standard that all US and Canadian allopathic medical schools must meet in order for the school to award the degree of medical doctor. The Uniformed Services University of the Health Sciences (USU) recently underwent a full-scale LCME accreditation visit that was conducted under the newly revised LCME standards and elements...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28724682/from-the-memphis-model-to-the-north-carolina-way-lessons-learned-from-emerging-health-system-and-faith-community-partnerships
#14
Teresa Cutts, Gary Gunderson, Dean Carter, Melanie Childers, Phillip Long, Lisa Marisiddaiah, Helen Milleson, Dennis Stamper, Annika Archie, Jeremy Moseley, Emily Viverette, Bobby Baker
National health care policy has encouraged health systems to develop community partnerships designed to decrease costs and readmissions, particularly for underserved populations. This commentary describes and compares the Congregational Health Network's Memphis Model to early local efforts at clinical-faith community partnerships in North Carolina, which we call "The North Carolina Way." Necessary components for building robust health system and congregational partnerships to address social determinants of health and impact health care utilization include partnership growth, allocation of health system resources, community trust, and time...
July 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28724672/accountable-care-communities-moving-from-health-care-delivery-systems-to-systems-of-health
#15
Berkeley Yorkery
Research has shown that individuals' health outcomes often have more to do with the conditions in which they live, learn, work, and age than the medical care they receive. However, traditional health care is not designed to address the social, behavioral, and economic factors (eg, housing, transportation, access to healthy food, education, and health behaviors) that impact health outcomes. Accountable care communities are showing that it is possible to design systems that are successful at both addressing social and economic factors and improving population health...
July 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28724472/appraisal-of-the-preparedness-of-midwives-and-nurses-in-bahrain-to-conduct-early-screening-for-zika-virus-infection-in-pregnant-women
#16
Asokan G V, Mariam Mohammed Baqer Nama, Feryal Juma Salman, Zainab Habib Ali AlGhareeb, Ali Moosa Almoosawi, Ridha Abdulla Al Hammam, Muyssar Sabri Awadhalla
OBJECTIVE: To appraise the awareness and knowledge levels of midwives and nurses concerning early screening for Zika virus (ZIKV) infection among pregnant women attending health care facilities in Bahrain. METHODS: This was a cross-sectional, purposely chosen study of Bahraini and expatriate midwives, nurses, and supervisors employed in gynecology/obstetrics and labor wards of Salmanya hospital, a maternity hospital, 4 private hospitals, and health centers in Bahrain...
July 20, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28724154/mapping-residency-global-health-experiences-to-the-acgme-family-medicine-milestones
#17
Maureen O Grissom, Tochi Iroku-Malize, Rita Peila, Marco Perez, Neubert Philippe
BACKGROUND AND OBJECTIVES: Global health (GH) experiences are a unique part of family medicine (FM) training that offer an opportunity for residents to demonstrate development across a multitude of the milestones recently implemented by the Accreditation Council for Graduate Medical Education (ACGME). The GH experience presents an opportunity for resident development, and including a component of written reflection can provide tangible evidence of development in areas that can be difficult to assess...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28724020/the-home-care-teaching-and-learning-process-in-undergraduate-health-care-degree-courses
#18
Ana Paula Hermann, Maria Ribeiro Lacerda, Mariluci Alves Maftum, Elizabeth Bernardino, Ana Lúcia Schaefer Ferreira de Mello
Home care, one of the services provided by the health system, requires health practitioners who are capable of understanding its specificities. This study aimed to build a substantive theory that describes experiences of home care teaching and learning during undergraduate degree courses in nursing, pharmacy, medicine, nutrition, dentistry and occupational therapy. A qualitative analysis was performed using the grounded theory approach based on the results of 63 semistructured interviews conducted with final year students, professors who taught subjects related to home care, and recent graduates working with home care, all participants in the above courses...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28723244/evaluation-of-the-national-health-service-nhs-direct-pilot-telehealth-program-cost-effectiveness-analysis
#19
Malcolm Clarke, Joanna Fursse, Nancy Connolly, Urvashi Sharma, Russell Jones
OBJECTIVE: To evaluate the cost-effectiveness of a pilot telehealth program applied to a wide population of patients with chronic obstructive pulmonary disease (COPD). DESIGN: Vital signs data were transmitted from the home of the patient on a daily basis using a patient monitoring system for review by community nurse to assist decisions on management. SETTING: Community services for patients diagnosed with COPD. PARTICIPANTS: Two Primary Care Trusts (PCTs) enrolled 321 patients diagnosed with COPD into the telehealth program...
July 18, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28722621/health-care-access-during-the-ebola-virus-epidemic-in-liberia
#20
Patricia A McQuilkin, Kanagasabai Udhayashankar, Michelle Niescierenko, Louise Maranda
The Ebola virus disease (EVD) epidemic, which began in West Africa in December 2013, claimed more than 11,000 lives, with more than 4,800 of these deaths occurring in Liberia. The epidemic had an additional effect of paralyzing the health-care systems in affected countries, which led to even greater mortality and morbidity. Little is known about the impact that the epidemic had on the provision of basic health care. During the period from March to May 2015, we undertook a nationwide, community-based survey to learn more about health-care access during the EVD epidemic in Liberia...
July 10, 2017: American Journal of Tropical Medicine and Hygiene
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