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https://www.readbyqxmd.com/read/29901152/estrogen%C3%A2-related-receptor-%C3%AE-promotes-the-migration-and-metastasis-of-endometrial-cancer-cells-by-targeting-s100a4
#1
Teng Hua, Xiaoxiao Wang, Shuqi Chi, Yan Liu, Dilu Feng, Yingchao Zhao, Hongbo Wang
S100 calcium binding protein A4 (S100A4) is a well‑established tumor metastasis mediator in various malignancies, including endometrial cancer (EC). However, the regulatory mechanism underlying S100A4 expression remains elusive. In the present study, by analyzing public datasets and clinical samples, we found that estrogen‑related receptor γ (ERRγ) was upregulated and positively correlated with S100A4 transcription in EC. ERRγ knockdown inhibited S100A4 expression and promoted the expression of its downstream target E‑cadherin, and vice versa...
June 4, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29888756/estrogen-related-receptors-mediate-the-adaptive-response-of-brown-adipose-tissue-to-adrenergic-stimulation
#2
Erin L Brown, Bethany C Hazen, Elodie Eury, Jean-Sébastien Wattez, Marin L Gantner, Verena Albert, Sarah Chau, Manuel Sanchez-Alavez, Bruno Conti, Anastasia Kralli
Adrenergic stimulation of brown adipose tissue (BAT) induces acute and long-term responses. The acute adrenergic response activates thermogenesis by uncoupling oxidative phosphorylation and enabling increased substrate oxidation. Long-term, adrenergic signaling remodels BAT, inducing adaptive transcriptional changes that expand thermogenic capacity. Here, we show that the estrogen-related receptors alpha and gamma (ERRα, ERRγ) are collectively critical effectors of adrenergically stimulated transcriptional reprogramming of BAT...
April 27, 2018: iScience
https://www.readbyqxmd.com/read/29862528/estrogen-related-receptor-alpha-triggers-the-proliferation-and-migration-of-human-non-small-cell-lung-cancer-via-interleukin-6
#3
Jing Zhang, Xiangqian Guan, Naixin Liang, Shanqing Li
Human non-small cell lung cancer (NSCLC) is one of the leading causes of cancer deaths worldwide. Estrogenic signals have been suggested to be important for the growth and metastasis of NSCLC cells. Our present data showed that estrogen-related receptor alpha (ERRα), while not ERRβ or ERRγ, was significantly elevated in NSCLC cell lines as compared with that in normal bronchial epithelial cell line BEAS-2B. The expression of ERRα in clinical NSCLC tissues was significantly greater than that in their matched normal adjacent tissues...
June 3, 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29781387/estrogen-related-receptor-alpha-triggers-the-migration-and-invasion-of-endometrial-cancer-cells-via-up-regulation-of-tgfb1
#4
Xiumin Huang, Xuelian Wang, Jing Shang, Zhiqin Zhaang, Binbin Cui, Yanzhen Lin, Ying Yang, Youyi Song, Shengnan Yu, Junjie Xia
Estrogenic signals have been suggested to be important for the tumorigenesis and progression of endometrial cancer (EC) cells. Our present data showed that estrogen related receptor alpha (ERRα), while not ERRβ or ERRγ, was significantly elevated in EC cells and tissues when compared to their controls. Targeted inhibition of ERRα by siRNA or its inverse agonist XCT-790 can suppress the migration and invasion of EC cells. Both si-ERRα and XCT-790 decreased the expression of transforming growth factor-beta (TGF-β)...
May 21, 2018: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/29735694/genomic-integration-of-err%C3%AE-hnf1%C3%AE-regulates-renal-bioenergetics-and-prevents-chronic-kidney-disease
#5
Juanjuan Zhao, Katherine Lupino, Benjamin J Wilkins, Chengxiang Qiu, Jian Liu, Yasuhiro Omura, Amanda L Allred, Caitlin McDonald, Katalin Susztak, Grant D Barish, Liming Pei
Mitochondrial dysfunction is increasingly recognized as a critical determinant of both hereditary and acquired kidney diseases. However, it remains poorly understood how mitochondrial metabolism is regulated to support normal kidney function and how its dysregulation contributes to kidney disease. Here, we show that the nuclear receptor estrogen-related receptor gamma (ERRγ) and hepatocyte nuclear factor 1 beta (HNF1β) link renal mitochondrial and reabsorptive functions through coordinated epigenomic programs...
May 22, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29619877/the-estrogen-related-receptors-in-metabolism-and-cancer-newer-insights
#6
Harmit S Ranhotra
The eukaryotic nuclear receptors (NRs) super-family of transcriptional factors include the estrogen-related receptors (ERRs) that have diverse roles in control of cellular energy balance, general metabolism, growth and development, immunity etc. Mouse knock-out models of specific ERR isoforms (ERRα, ERRβ and ERRγ) exhibit defects in several phenotypic traits. Newer findings indicate important roles of ERRs in the regulation of brown adipocyte tissue mitochondrial oxidative functions as well as metabolic control in association with hypoxia-inducible factors during cellular hypoxic state...
April 2018: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/29548571/design-synthesis-and-evaluation-of-simple-phenol-amides-as-err%C3%AE-agonists
#7
Hua Lin, Christelle Doebelin, Rémi Patouret, Ruben D Garcia-Ordonez, M R Chang, Venkatasubramanian Dharmarajan, Claudia Ruiz Bayona, Michael D Cameron, Patrick R Griffin, Theodore M Kamenecka
Herein we report the design and synthesis of a series of simple phenol amide ERRγ agonists based on a hydrazone lead molecule. Our structure activity relationship studies in this series revealed the phenol portion of the molecule to be required for activity. Attempts to replace the hydrazone with more suitable chemotypes led to a simple amide as a viable alternative. Differential hydrogen-deuterium exchange experiments were used to help understand the structural basis for binding to ERRγ and aid in the development of more potent ligands...
May 1, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29539415/err%C3%AE-preserves-brown-fat-innate-thermogenic-activity
#8
Maryam Ahmadian, Sihao Liu, Shannon M Reilly, Nasun Hah, Weiwei Fan, Eiji Yoshihara, Pooja Jha, C Daniel De Magalhaes Filho, Sandra Jacinto, Andrew V Gomez, Yang Dai, Ruth T Yu, Christopher Liddle, Annette R Atkins, Johan Auwerx, Alan R Saltiel, Michael Downes, Ronald M Evans
Brown adipose tissue (BAT) adaptively transfers energy from glucose and fat into heat by inducing a gene network that uncouples mitochondrial electron transport. However, the innate transcription factors that enable the rapid adaptive response of BAT are unclear. Here, we identify estrogen-related receptor gamma (ERRγ) as a critical factor for maintaining BAT identity. ERRγ is selectively expressed in BAT versus WAT, in which, in the absence of PGC1α, it drives a signature transcriptional network of thermogenic and oxidative genes in the basal (i...
March 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29514081/err%C3%AE-promotes-angiogenesis-mitochondrial-biogenesis-and-oxidative-remodeling-in-pgc1%C3%AE-%C3%AE-deficient-muscle
#9
Weiwei Fan, Nanhai He, Chun Shi Lin, Zong Wei, Nasun Hah, Wanda Waizenegger, Ming-Xiao He, Christopher Liddle, Ruth T Yu, Annette R Atkins, Michael Downes, Ronald M Evans
PGC1α is a pleiotropic co-factor that affects angiogenesis, mitochondrial biogenesis, and oxidative muscle remodeling via its association with multiple transcription factors, including the master oxidative nuclear receptor ERRγ. To decipher their epistatic relationship, we explored ERRγ gain of function in muscle-specific PGC1α/β double-knockout (PKO) mice. ERRγ-driven transcriptional reprogramming largely rescues muscle damage and improves muscle function in PKO mice, inducing mitochondrial biogenesis, antioxidant defense, angiogenesis, and a glycolytic-to-oxidative fiber-type transformation independent of PGC1α/β...
March 6, 2018: Cell Reports
https://www.readbyqxmd.com/read/29505923/mir-204-5p-regulates-c2c12-myoblast-differentiation-by-targeting-mef2c-and-err%C3%AE
#10
Xiao Cheng, Jingjing Du, Linyuan Shen, Zhendong Tan, Dongmei Jiang, Anan Jiang, Qiang Li, Guoqing Tang, Yanzhi Jiang, Jinyong Wang, Xuewei Li, Shunhua Zhang, Li Zhu
Myogenic differentiation, which occurs in the process of muscle development, is a highly ordered process. Increasing evidence indicates that microRNAs (miRNAs) are important regulators in myogenic processes. In this study, we found that miR-204-5p expression gradually decreased when myoblasts were induced to differentiate. Our results suggested that miR-204-5p blunted myoblast differentiation, which was accompanied with a decreased proportion of myosin heavy chain (MyHC)-positive cells in myoblasts with augmented expression of miR-204-5p...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29428396/concerns-related-to-ed-mediated-effects-of-bisphenol-a-and-their-regulatory-consideration
#11
REVIEW
François Pouzaud, Morgane Thierry-Mieg, Karen Burga, Lauranne Vérines-Jouin, Karine Fiore, Claire Beausoleil, Cécile Michel, Christophe Rousselle, Elodie Pasquier
The extensive database on BPA provides strong evidence of its adverse effects on reproductive, neurobehavioural, metabolic functions and mammary gland. Disruption of estrogenic pathway is central in the mediation of these effects although other modes of action may be involved. BPA has a weak affinity for ERα/β but interaction with extranuclearly located pathways activated by estrogens such as ERRγ and GPER reveals how BPA can act at low doses. The effects are observed later in life after developmental exposure and are associated with pathologies of major societal concern in terms of severity, incidence, impact on quality of life, burden on public health system...
February 8, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29366446/estrogen-related-receptor-%C3%AE-is-a-novel-catabolic-regulator-of-osteoarthritis-pathogenesis
#12
Young-Ok Son, Jang-Soo Chun
Osteoarthritis (OA) is the most common form of arthritis and is a leading cause of disability with a large socioeconomic cost. OA is a whole-joint disease characterized by cartilage destruction, synovial inflammation, osteophyte formation, and subchondral bone sclerosis. To date, however, no effective disease-modifying therapies for OA have been developed. The estrogen-related receptors (ERRs), a family of orphan nuclear receptor transcription factors, are composed of ERRα, ERRβ, and ERRγ, which play diverse biological functions such as cellular energy metabolism...
April 2018: BMB Reports
https://www.readbyqxmd.com/read/29360794/estrogen-and-androgen-blockade-for-advanced-prostate-cancer-in-the-era-of-precision-medicine
#13
REVIEW
Tetsuya Fujimura, Kenichi Takayama, Satoru Takahashi, Satoshi Inoue
Androgen deprivation therapy (ADT) has been widely prescribed for patients with advanced prostate cancer (PC) to control key signaling pathways via androgen receptor (AR) and AR-collaborative transcriptional factors; however, PC gradually acquires a lethal phenotype and results in castration-resistant PC (CRPC) during ADT. Therefore, new therapeutic strategies are required in clinical practice. In addition, ARs; estrogen receptors (ERs; ERα and ERβ); and estrogen-related receptors (ERRs; ERRα, ERRβ, and ERRγ) have been reported to be involved in the development or regulation of PC...
January 23, 2018: Cancers
https://www.readbyqxmd.com/read/29345032/mirna-320a-inhibits-trophoblast-cell-invasion-by-targeting-estrogen-related-receptor-gamma
#14
Tian Gao, Mou Deng, Qian Wang
AIM: MicroRNAs (miRs) play an essential role in the modulation of trophoblast function. We explored miR-320a expression in the human placenta. In addition, we report the promising effect and target functional loop of miR-320a in trophoblasts. METHODS: MiR-320a expression was investigated in both pre-eclamptic and healthy placenta tissues by quantitative real time-polymerase chain reaction to determine how miR-320a affected invasion, proliferation and migration in trophoblasts...
January 18, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29247173/estrogen-related-receptor-%C3%AE-causes-osteoarthritis-by-upregulating-extracellular-matrix-degrading-enzymes
#15
Young-Ok Son, Seulki Park, Ji-Sun Kwak, Yoonkyung Won, Wan-Su Choi, Jinseol Rhee, Churl-Hong Chun, Je-Hwang Ryu, Don-Kyu Kim, Hueng-Sik Choi, Jang-Soo Chun
The estrogen-related receptor (ERR) family of orphan nuclear receptor is composed of ERRα, ERRβ, and ERRγ, which are known to regulate various isoform-specific functions under normal and pathophysiological conditions. Here, we investigate the involvement of ERRs in the pathogenesis of osteoarthritis (OA) in mice. Among ERR family members, ERRγ is markedly upregulated in cartilage from human OA patients and various mouse models of OA. Adenovirus-mediated overexpression of ERRγ in mouse knee joint or transgenic expression of ERRγ in cartilage leads to OA...
December 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/29246124/transcriptome-analysis-of-genes-associated-with-breast-cancer-cell-motility-in-response-to-artemisinin-treatment
#16
Kanchan Kumari, Sunita Keshari, Debomita Sengupta, Surendra C Sabat, Sandip K Mishra
BACKGROUND: Well-known anti-malarial drug artemisinin exhibits potent anti-cancerous activities. In-vivo and in-vitro studies showed its anti-tumor and immunomodulatory properties signifying it as a potent drug candidate for study. The studies of mechanisms of cell movement are relevant which can be understood by knowing the involvement of genes in an effect of a drug. Although cytotoxicity and anti-proliferative activity of artemisinin is evident, the genes participating in its anti-migratory and reduced invasive effect are not well studied...
December 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29061011/-the-role-of-estrogen-related-receptor-%C3%AE-and-atp-dependent-k-channel-kcnj1-in-renal-ischemia-reperfusion-injury
#17
Z M Wu, Q Yang, Z Y Li, D Chen, L J Jiang, X D Li, S L Chen, Z W Liu
Objective: To investigate the correlation between estrogen related-receptorγ (ERRγ) and ATP-dependent K(+) channel Kcnj1 in renal ischemia-reperfusion injury and its possible role in regulating ischemic preconditioning. Methods: The expression of ERRγ in kidney tissues was detected by immunohistochemistry. The expressions of ERRγ and Kcnj1 in human renal tubular epithelial cells (HK-2) under hypoxia (1% O(2)) were detected by RT-PCR. The ERRγ-deficient heterozygous mice model and the ERRγ-deficient completely mice model were established...
October 17, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28993941/il-8-is-involved-in-estrogen-related-receptor-%C3%AE-regulated-proliferation-and-migration-of-colorectal-cancer-cells
#18
Sijuan Ding, Zhaohui Tang, Yongjun Jiang, Honglin Huang, Pengfei Luo, Bohua Qing, Siyuan Zhang, Ruoting Tang
BACKGROUND AND AIMS: Studies revealed that estrogenic signals were involved in the development of colorectal cancer (CRC), while the roles of estrogen related receptor (ERR) on the progression of CRC have not been well illustrated. Its roles on the development of CRC were investigated. METHODS: The expression of ERRα/β/γ in CRC cells were measured. The effects of ERRα on cell proliferation, migration and expression of cytokines were investigated accordingly...
December 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28882502/design-and-synthesis-of-benzoacridines-as-estrogenic-and-anti-estrogenic-agents
#19
Kohei Torikai, Rintaro Koga, Xiaohui Liu, Kaoru Umehara, Tatsuya Kitano, Kenji Watanabe, Tohru Oishi, Hiroshi Noguchi, Yasuyuki Shimohigashi
Estrogens play undisputedly important physiological roles, but lifetime exposure to estrogens has also been linked to the development of breast cancer. Moreover, imbalanced estrogen levels have been associated with various symptoms such as osteoporosis and menopausal disorders. For the improvement of such estrogen imbalances, estrogenic reagents with regulatory properties have shown promising potential. Herein, we report the construction of a 12-arylbenzoacridine library via a diversity-oriented strategy that furnished non-toxic estrogenic and anti-estrogenic agents...
October 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28820402/does-signaling-of-estrogen-related-receptors-affect-structure-and-function-of-bank-vole-leydig-cells
#20
P Pawlicki, A Milon, M Zarzycka, J Galas, W Tworzydlo, A Kaminska, L Pardyak, K Lesniak, A Pacwa, B Bilinska, E Gorowska-Wojtowicz, M Kotula-Balak
To get a deeper insight into the function of estrogen-related receptors (ERRs) and dissect underlying mechanism in Leydig cells, ERRs (type α, β and γ) were blocked or activated in testes of adult bank voles (Myodes glareolus) which show seasonal changes in the intratesticular sex hormones level. Both actively reproducing animals (long day conditions; LD) and those with regression of the reproductive system (short day conditions; SD) received intraperitoneal injections of selective ERRα antagonist 3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide (XCT 790) or selective ERRβ/ERRγ agonist N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine (DY131) (50 μ/kg bw; six doses every other day)...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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