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https://www.readbyqxmd.com/read/28525844/the-discovery-of-novel-potent-err-alpha-inverse-agonists-for-the-treatment-of-triple-negative-breast-cancer
#1
Yongli Du, Lianhua Song, Liudi Zhang, Hao Ling, Yanhui Zhang, Haifei Chen, Huijie Qi, Xiaojin Shi, Qunyi Li
The estrogen-related receptor α (ERRα) is an orphan receptor and a novel target for solid tumor therapy, conceivably through effects on the regulation of tumor cell energy metabolism associated with energy stress within solid tumor micro environments. Here we describe the discovery of novel potent inverse agonists of ERRα. In vitro, compound 11 potently inhibits ERRα's transcriptional activity by preventing endogenous PGC-1α and ERRα binding and suppresses the proliferation of different human cancer cell lines and the migration of breast cancer cells (MDA-MB-231)...
April 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28512482/effect-of-field-of-view-on-detection-of-external-root-resorption-in-cone-beam-computed-tomography
#2
(no author information available yet)
INTRODUCTION: Conventional methods for diagnosis of external root resorption (ERR) are based on clinical findings and x-ray observations which are not appropriate for early diagnosis. The present study assessed the effect of different sizes and field of views (FOVs) in the diagnosis of simulated external root resorption by cone-beam computed tomography (CBCT). METHODS AND MATERIALS: In this diagnostic in vitro trial, 100 human extracted mandibular central incisors were collected and marked in 3 apical, middle and coronal areas...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28510140/nuclear-receptors-ecr-usp-e75-dhr3-and-err-regulate-transcription-of-ecdysone-cascade-genes
#3
M Yu Mazina, E V Kocheryzhkina, J V Nikolenko, A N Krasnov, S G Georgieva, N E Vorobyeva
We found that an increase in the expression level of E75, DHR3, and ERR increases the degree of activation of dhr3 and hr4 genes in Drosophila S2 cells. We also detected a repressing effect of these nuclear receptors on the basal transcription level of these genes. This is the first study to show the ability of nuclear receptors E75, DHR3, and ERR to function as activators or repressors depending on external conditions. We also confirmed the existence of the interaction of all studied nuclear receptors with the promoters of dhr3 and hr4 genes of the ecdysone cascade in vivo...
March 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28504525/introspection-of-subjective-feelings-is-sensitive-and-specific
#4
Laurence Questienne, Jean-Philippe van Dijck, Wim Gevers
Conversely to behaviorist ideas, recent studies suggest that introspection can be accurate and reliable. However, an unresolved question is whether people are able to report specific aspects of their phenomenal experience, or whether they report more general nonspecific experiences. To address this question, we investigated the sensitivity and validity of our introspection for different types of conflict. Taking advantage of the congruency sequence effect, we dissociated response conflict while keeping visual conflict unchanged in a Stroop and in a priming task...
May 15, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28501000/combination-of-a-biodegradable-three-dimensional-3d-printed-cage-for-mechanical-support-and-nanofibrous-membranes-for-sustainable-release-of-antimicrobial-agents-for-treating-the-femoral-metaphyseal-comminuted-fracture
#5
Ying-Chao Chou, Demei Lee, Tzu-Min Chang, Yung-Heng Hsu, Yi-Hsun Yu, Err-Cheng Chan, Shih-Jung Liu
The aim of this study was to develop a biodegradable three-dimensional-printed polylactide (PLA) cage for promoting bony fixation and an antibiotics-embedded poly(d,l)-lactide-co-glycolide (PLGA) nanofibrous membrane for infectious prophylaxis during treating the comminuted metaphyseal fracture in a rabbit femoral model. The in vitro studies included measuring the mechanical properties of the 3D printed cage and determining release activities of vancomycin and ceftazidime from the nanofibers. The in vivo study included comparisons of rabbits of the femoral metaphyseal comminuted fracture treated with or without the combined biodegradable polymers...
May 2, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28486311/free-living-amoebae-keratitis
#6
Antonio Pinna, Tiziana Porcu, Francesco Boscia, Antonella Cano, Giuseppe Erre, Antonella Mattana
PURPOSE: To describe the diagnostic and clinical features and treatment results in 43 consecutive patients with microbiologically proven free-living amoebae (FLA) keratitis. METHODS: In this hospital-based, prospective case series, corneal scrapings from 43 patients with presumed amoebic keratitis were plated on nonnutrient agar. Amoebic isolates were identified morphologically and by the polymerase chain reaction. All patients with culture-proven FLA keratitis were treated with polyhexamethylene biguanide (PHMB) 0...
May 8, 2017: Cornea
https://www.readbyqxmd.com/read/28481037/regional-quantification-of-myocardial-mechanics-in-rat-using-3d-cine-dense-cardiovascular-magnetic-resonance
#7
Xiaoyan Zhang, Zhan-Qiu Liu, Dara Singh, Gregory J Wehner, David K Powell, Kenneth S Campbell, Brandon K Fornwalt, Jonathan F Wenk
Rat models have assumed an increasingly important role in cardiac research. However, a detailed profile of regional cardiac mechanics, such as strains and torsion, is lacking for rats. We hypothesized that healthy rat left ventricles (LVs) exhibit regional differences in cardiac mechanics, which are part of normal function. In this study, images of the LV were obtained with 3D cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance in 10 healthy rats. To evaluate regional cardiac mechanics, the LV was divided into basal, mid-ventricular, and apical regions...
May 8, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28455959/ovol2-antagonizes-tgf-%C3%AE-signaling-to-regulate-epithelial-to-mesenchymal-transition-during-mammary-tumor-metastasis
#8
Rong-Si Wu, Jing-Jing Hong, Jia-Fa Wu, Shen Yan, Di Wu, Na Liu, Qing-Feng Liu, Qiu-Wan Wu, Yuan-Yuan Xie, Yun-Jia Liu, Zhong-Zheng Zheng, Err-Cheng Chan, Zhi-Ming Zhang, Bo-An Li
Great progress has been achieved in the study of the role of TGF-β signaling in triggering epithelial-mesenchymal transition (EMT) in a variety of cancers; however, the regulation of TGF-β signaling during EMT in mammary tumor metastasis has not been completely defined. In the present study, we demonstrated that OVOL2, a zinc finger transcription factor, inhibits TGF-β signaling-induced EMT in mouse and human mammary tumor cells, as well as in mouse tumor models. Data from the Oncomine databases indicated a strong negative relationship between OVOL2 expression and breast cancer progression...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28449672/compressed-sensing-mri-via-fast-linearized-preconditioned-alternating-direction-method-of-multipliers
#9
Shanshan Chen, Hongwei Du, Linna Wu, Jiaquan Jin, Bensheng Qiu
BACKGROUND: The challenge of reconstructing a sparse medical magnetic resonance image based on compressed sensing from undersampled k-space data has been investigated within recent years. As total variation (TV) performs well in preserving edge, one type of approach considers TV-regularization as a sparse structure to solve a convex optimization problem. Nevertheless, this convex optimization problem is both nonlinear and nonsmooth, and thus difficult to handle, especially for a large-scale problem...
April 27, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28449330/exploring-the-experience-of-nurse-practitioners-who-have-committed-medical-errors-a-phenomenological-approach
#10
Romuald Delacroix
BACKGROUND AND PURPOSE: To explore the experience of committing medical error from the perspective of nurse practitioners (NPs). Overall, the purpose of the study is to discern NPs' behaviors, perceptions, and coping mechanisms in response to having made a medical error. METHODS: Qualitative research based on two face-to-face audio-recorded semistructured interviews with 10 NPs who had made medical errors in practice. The analysis was guided by concepts in phenomenology...
April 27, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28445559/association-of-us-centers-for-medicare-and-medicaid-services-hospital-30-day-risk-standardized-readmission-metric-with-care-quality-and-outcomes-after-acute-myocardial-infarction-findings-from-the-national-cardiovascular-data-registry-acute-coronary-treatment
#11
Ambarish Pandey, Harsh Golwala, Hurst M Hall, Tracy Y Wang, Di Lu, Ying Xian, Karen Chiswell, Karen E Joynt, Abhinav Goyal, Sandeep R Das, Dharam Kumbhani, Howard Julien, Gregg C Fonarow, James A de Lemos
Importance: The US Centers for Medicare and Medicaid Services Hospital Readmissions Reduction Program penalizes hospitals with higher-than-expected risk-adjusted 30-day readmission rates (excess readmission ratio [ERR] > 1) after acute myocardial infarction (MI). However, the association of ERR with MI care processes and outcomes are not well established. Objective: To evaluate the association between ERR for MI with in-hospital process of care measures and 1-year clinical outcomes...
April 26, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28442644/prediction-of-both-electrical-and-mechanical-reverse-remodeling-on-acute-electrocardiogram-changes-after-cardiac-resynchronization-therapy
#12
Chien-Ming Cheng, Chieh-Shou Su, Pesus Chou, Ying-Chieh Liao, Chi-Yen Wang, Jian-Rong Zhang, Yu-Cheng Hsieh, Tsu-Juey Wu, Yu-Wei Chen, Chi-Jen Weng, Keng-Hao Chang, Weihua Zhou, Guang-Uei Hung, Jin-Long Huang, Kenichi Nakajima
BACKGROUND: The development of both electrical reverse remodeling and mechanical reverse remodeling (ERR+MRR) after cardiac resynchronization therapy (CRT) implantation could reduce the incidence of lethal arrhythmia, hence the prediction of ERR+MRR is clinically important.Methods and Results:Eighty-three patients (54 male; 67±12 years old) with CRT >6 months were enrolled. ERR was defined as baseline intrinsic QRS duration (iQRSd) shortening ≥10 ms in lead II on ECG after CRT, and MRR as improvement in LVEF ≥25% on echocardiography after CRT...
April 22, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28421857/risk-of-solid-cancer-in-low-dose-rate-radiation-epidemiological-studies-and-the-dose-rate-effectiveness-factor
#13
Roy Shore, Linda Walsh, Tamara Azizova, Werner Rühm
PURPOSE: Estimated radiation risks used for radiation protection purposes have been based primarily on the Life Span Study (LSS) of atomic bomb survivors who received brief exposures at high dose rates, many with high doses. Information is needed regarding radiation risks from low dose-rate (LDR) exposures to low linear-energy-transfer (low-LET) radiation. We conducted a meta-analysis of LDR epidemiologic studies that provide dose-response estimates of total solid cancer risk in adulthood in comparison to corresponding LSS risks, in order to estimate a dose rate effectiveness factor (DREF)...
April 19, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28406375/who-dares-who-errs-disentangling-cognitive-and-motivational-roots-of-age-differences-in-decisions-under-risk
#14
Thorsten Pachur, Rui Mata, Ralph Hertwig
We separate for the first time the roles of cognitive and motivational factors in shaping age differences in decision making under risk. Younger and older adults completed gain, loss, and mixed-domain choice problems as well as measures of cognitive functioning and affect. The older adults' decision quality was lower than the younger adults' in the loss domain, and this age difference was attributable to the older adults' lower cognitive abilities. In addition, the older adults chose the more risky option more often than the younger adults in the gain and mixed domains; this difference in risk aversion was attributable to less pronounced negative affect among the older adults...
April 2017: Psychological Science
https://www.readbyqxmd.com/read/28392861/reported-exercise-related-respiratory-symptoms-and-exercise-induced-bronchoconstriction-in-asthmatic-children
#15
Demet Inci, Refoel Guggenheim, Derya Ufuk Altintas, Johannes H Wildhaber, Alexander Moeller
BACKGROUND: Unlimited physical activity is one of the key issues of asthma control and management. We investigated how reliable reported exercise-related respiratory symptoms (ERRS) are in predicting exercise-induced bronchoconstriction (EIB) in asthmatic children. METHODS: In this prospective study, 179 asthmatic children aged 7 - 15 years were asked for specific questions on respiratory symptoms related to exercise and allocated into two groups according to whether they complained about symptoms...
May 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28387560/clinical-evaluation-of-the-concussed-athlete-a-view-from-the-sideline
#16
Margot Putukian
CONTEXT: The sideline assessment of concussion is challenging, given its variable presentations, the limited sensitivity and specificity of sideline assessment tools, and how the presentation of the injury evolves over time. In addition, the diagnostic process, as well as the tools used to assess and manage concussion, continue to progress as research and what we know about concussion advance. This paper focuses on the initial assessment on the sideline by reviewing the concussion-evaluation literature, drawing from clinical experience to emphasize a standardized approach, and underscoring the importance of both familiarity with the athlete and clinical judgment...
March 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28385154/efficacy-of-praziquantel-on-schistosoma-haematobium-and-re-infection-rates-among-school-going-children-in-the-ndumo-area-of-umkhanyakude-district-kwazulu-natal-south-africa
#17
Muhubiri Kabuyaya, Moses John Chimbari, Tawanda Manyangadze, Samson Mukaratirwa
BACKGROUND: Despite its low cure rates and possible resistance, praziquantel (PZQ) is the only drug available for schistosomiasis treatment. Hence, monitoring its efficacy is crucial. This study assessed the efficacy of PZQ, determined re-infection and incidence rates of Schistosoma haematobium infection among school-going children in the Ndumo area, KwaZulu-Natal. METHODS: A cohort of 320 school-going children (10 - 15 years) in 10 primary schools was screened for S...
April 7, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28370607/evidence-for-a-role-of-oestrogen-receptor-related-receptor-in-the-regulation-of-male-sexual-behaviour-in-the-moth-agrotis-ipsilon
#18
F Bozzolan, N Durand, E Demondion, T Bourgeois, E Gassias, S Debernard
The oestrogen receptor-related receptors (ERRs) are orphan nuclear receptors that were originally identified on the basis of their close homology to the oestrogen receptors. The three mammalian ERR genes participate in the regulation of vital physiological processes including reproduction, development and metabolic homeostasis. Although unique ERRs have been found in insects, data on the function and regulation of these receptors remain sparse. In the present study, a 2095-bp full-length cDNA encoding an ERR, termed AiERR, was isolated from males of the moth Agrotis ipsilon and deposited in the GenBank database under the accession number KT944662...
March 29, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/28369141/correction-of-confidence-intervals-in-excess-relative-risk-models-using-monte-carlo-dosimetry-systems-with-shared-errors
#19
Zhuo Zhang, Dale L Preston, Mikhail Sokolnikov, Bruce A Napier, Marina Degteva, Brian Moroz, Vadim Vostrotin, Elena Shiskina, Alan Birchall, Daniel O Stram
In epidemiological studies, exposures of interest are often measured with uncertainties, which may be independent or correlated. Independent errors can often be characterized relatively easily while correlated measurement errors have shared and hierarchical components that complicate the description of their structure. For some important studies, Monte Carlo dosimetry systems that provide multiple realizations of exposure estimates have been used to represent such complex error structures. While the effects of independent measurement errors on parameter estimation and methods to correct these effects have been studied comprehensively in the epidemiological literature, the literature on the effects of correlated errors, and associated correction methods is much more sparse...
2017: PloS One
https://www.readbyqxmd.com/read/28350475/occupational-radiation-exposure-and-deaths-from-malignant-intracranial-neoplasms-of-the-brain-and-cns-in-u-s-radiologic-technologists-1983-2012
#20
Cari M Kitahara, Martha S Linet, Stephen Balter, Donald L Miller, Preetha Rajaraman, Elizabeth K Cahoon, Raquel Velazquez-Kronen, Steven L Simon, Mark P Little, Michele M Doody, Bruce H Alexander, Dale L Preston
OBJECTIVE: Childhood exposure to acute, high-dose radiation has consistently been associated with risk of benign and malignant intracranial tumors of the brain and CNS, but data on risks of adulthood exposure to protracted, low-to-moderate doses of radiation are limited. In a large cohort of radiologic technologists, we quantified the association between protracted, low-to-moderate doses of radiation and malignant intracranial tumor mortality. MATERIALS AND METHODS: The study population included 83,655 female and 26,642 male U...
March 28, 2017: AJR. American Journal of Roentgenology
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