keyword
https://read.qxmd.com/read/36624847/ppar%C3%AE-and-c-ebp%C3%AE-response-to-acute-cold-stress-in-brown-adipose-tissue
#21
JOURNAL ARTICLE
Kin H Lau, Althea N Waldhart, Holly Dykstra, Tracey Avequin, Ning Wu
Brown adipose tissue (BAT) has the ability to burn calories as heat. Utilizing BAT thermogenesis is thus an attractive way to combat obesity. However, the transcriptional network resulting in the lipid synthesis to oxidation shift during thermogenesis is not completely understood. Here, we report the regulation of two master regulators of adipogenesis, peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα), during acute cold stress in BAT. We found PPARγ dissociates from DNA in a fifth of its binding sites and these include Cebpa enhancers, leading to decreased C/EBPα expression...
January 20, 2023: IScience
https://read.qxmd.com/read/36583689/innately-expressed-estrogen-related-receptors-in-the-skeletal-muscle-are-indispensable-for-exercise-fitness
#22
JOURNAL ARTICLE
Danesh H Sopariwala, Andrea S Rios, Guangsheng Pei, Anirban Roy, Meiricris Tomaz da Silva, Hao Thi Thu Nguyen, Addison Saley, Rachel Van Drunen, Anastasia Kralli, Kristin Mahan, Zhongming Zhao, Ashok Kumar, Vihang A Narkar
Transcriptional determinants in the skeletal muscle that govern exercise capacity, while poorly defined, could provide molecular insights into how exercise improves fitness. Here, we have elucidated the role of nuclear receptors, estrogen-related receptor alpha and gamma (ERRα/γ) in regulating myofibrillar composition, contractility, and exercise capacity in skeletal muscle. We used muscle-specific single or double (DKO) ERRα/γ knockout mice to investigate the effect of ERRα/γ deletion on muscle and exercise parameters...
February 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/36542664/err2-and-err3-promote-the-development-of-gamma-motor-neuron-functional-properties-required-for-proprioceptive-movement-control
#23
JOURNAL ARTICLE
Mudassar N Khan, Pitchaiah Cherukuri, Francesco Negro, Ashish Rajput, Piotr Fabrowski, Vikas Bansal, Camille Lancelin, Tsung-I Lee, Yehan Bian, William P Mayer, Turgay Akay, Daniel Müller, Stefan Bonn, Dario Farina, Till Marquardt
The ability of terrestrial vertebrates to effectively move on land is integrally linked to the diversification of motor neurons into types that generate muscle force (alpha motor neurons) and types that modulate muscle proprioception, a task that in mammals is chiefly mediated by gamma motor neurons. The diversification of motor neurons into alpha and gamma types and their respective contributions to movement control have been firmly established in the past 7 decades, while recent studies identified gene expression signatures linked to both motor neuron types...
December 21, 2022: PLoS Biology
https://read.qxmd.com/read/36534970/err%C3%AE-attenuates-vascular-inflammation-via-enhanced-nf%C3%AE%C2%BAb-degradation-pathway
#24
JOURNAL ARTICLE
Hiroyasu Yamamoto, Yuya Tanaka, Miho Sawada, Shinji Kihara
We have previously reported that β-aminoisobutyric acid (BAIBA), a muscle-derived exercise mimetic, had anti-inflammatory and reactive oxygen species (ROS) scavenging effects in vascular endothelial cells through the enhanced expression of peroxisome proliferator-activated receptor gamma coactivator-1β (PGC-1β). Although BAIBA also increased the expression of estrogen-related receptor α (ERRα), the roles of ERRα in vascular endothelial cells have yet to be fully elucidated...
December 19, 2022: Endocrinology
https://read.qxmd.com/read/36326926/incidence-risks-for-subtypes-of-heart-diseases-in-a-russian-cohort-of-mayak-production-association-nuclear-workers
#25
JOURNAL ARTICLE
Tamara V Azizova, Maria V Bannikova, Ksenia V Briks, Evgeniya S Grigoryeva, Nobuyuki Hamada
Heart diseases are one of the main causes of death. The incidence risks were assessed for various types of heart diseases (HDs) in a cohort of Russian nuclear workers of the Mayak Production Association (PA) who had been chronically occupationally exposed to external gamma and/ or internal alpha radiation. The study cohort included all workers (22,377 individuals) who had been hired at the Mayak PA during 1948-1982 and followed up until 31 December 2018. The mean gamma-absorbed dose to the liver (standard deviation) was 0...
November 3, 2022: Radiation and Environmental Biophysics
https://read.qxmd.com/read/35671754/the-risk-of-cancer-following-high-and-very-high-doses-of-ionising-radiation
#26
JOURNAL ARTICLE
Richard Wakeford, Michael Hauptmann
It is established that moderate-to-high doses of ionising radiation increase the risk of subsequent cancer in the exposed individual, but the question arises as to the risk of cancer from higher doses, such as those delivered during radiotherapy, accidents, or deliberate acts of malice. In general, the cumulative dose received during a course of radiation treatment is sufficiently high that it would kill a person if delivered as a single dose to the whole body, but therapeutic doses are carefully fractionated and high/very high doses are generally limited to a small tissue volume under controlled conditions...
June 17, 2022: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://read.qxmd.com/read/35457139/flying-without-a-net-space-radiation-cancer-risk-predictions-without-a-gamma-ray-basis
#27
JOURNAL ARTICLE
Francis A Cucinotta
The biological effects of high linear energy transfer (LET) radiation show both a qualitative and quantitative difference when compared to low-LET radiation. However, models used to estimate risks ignore qualitative differences and involve extensive use of gamma-ray data, including low-LET radiation epidemiology, quality factors (QF), and dose and dose-rate effectiveness factors (DDREF). We consider a risk prediction that avoids gamma-ray data by formulating a track structure model of excess relative risk (ERR) with parameters estimated from animal studies using high-LET radiation...
April 13, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35452522/extended-analysis-of-solid-cancer-incidence-among-the-nuclear-industry-workers-in-the-uk-1955-2011
#28
JOURNAL ARTICLE
Nezahat Hunter, Richard G E Haylock, Michael Gillies, Wei Zhang
Radiation worker studies provide direct estimates of cancer risk after protracted low-dose exposures to external X-ray and gamma-ray irradiations. The National Registry for Radiation Workers (NRRW) started in 1976 and has become the largest epidemiological program of research on nuclear workers in the UK. Here, we report on the relationship between solid cancer incidence and external radiation at the low-dose levels in 172,452 NRRW cohort members of whom (90%) were men. This study is based on 5.25 million person-years of follow-up from 1955 through the end of 2011...
April 22, 2022: Radiation Research
https://read.qxmd.com/read/35023506/mortality-from-various-diseases-of-the-circulatory-system-in-the-russian-mayak-nuclear-worker-cohort-1948-2018
#29
JOURNAL ARTICLE
Tamara V Azizova, Maria V Bannikova, Evgenia S Grigoryeva, Ksenia Briks, Nobuyuki Hamada
The paper reports on findings of the study of mortality from diseases of circulatory system (DCS) in Russian nuclear workers of the Mayak Production Association (22,377 individuals with 25.4% of females) who were hired at the facility in 1948-1982 and followed up until end-2018. Using the AMFIT module of EPICURE software, relative risks and excess relative risks per unit absorbed dose (ERR/Gy) for the entire Mayak cohort, the subcohort of workers who were residents of the dormitory town of Ozyorsk and the subcohort of migrants from Ozyorsk were calculated based on maximum likelihood...
January 13, 2022: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://read.qxmd.com/read/34669562/mortality-from-leukemia-cancer-and-heart-disease-among-u-s-nuclear-power-plant-workers-1957-2011
#30
JOURNAL ARTICLE
John D Boice, Sarah S Cohen, Michael T Mumma, Derek A Hagemeyer, Heidi Chen, Ashley P Golden, R Craig Yoder, Lawrence T Dauer
BACKGROUND: The aim of the Million Person Study (MPS) of Low Dose Health Effects is to examine the level of radiation risk for chronic exposures received gradually over time and not acutely as was the case for the Japanese atomic bomb survivors. Nuclear power plant (NPP) workers comprise nearly 15 percent of the MPS. Leukemia, selected cancers, Parkinson's disease, ischemic heart disease (IHD) and other causes of death are evaluated. METHODS AND MATERIAL: The U...
October 20, 2021: International Journal of Radiation Biology
https://read.qxmd.com/read/34648866/estrogen-related-receptor-alpha-err%C3%AE-is-required-for-pgc-1%C3%AE-dependent-gene-expression-in-the-mouse-brain
#31
JOURNAL ARTICLE
L J McMeekin, K L Joyce, L M Jenkins, B M Bohannon, K D Patel, A S Bohannon, A Patel, S N Fox, M S Simmons, J J Day, A Kralli, D K Crossman, R M Cowell
Deficiency in peroxisome proliferator-activated receptor gamma coactivator 1-alpha. (PGC-1α) expression or function is implicated in numerous neurological and psychiatric disorders. PGC-1α is required for the expression of genes involved in synchronous neurotransmitter release, axonal integrity, and metabolism, especially in parvalbumin-positive interneurons. As a transcriptional coactivator, PGC-1α requires transcription factors to specify cell-type-specific gene programs; while much is known about these factors in peripheral tissues, it is unclear if PGC-1α utilizes these same factors in neurons...
December 15, 2021: Neuroscience
https://read.qxmd.com/read/34161930/overview-of-epidemiological-studies-of-nuclear-workers-opportunities-expectations-and-limitations
#32
JOURNAL ARTICLE
Richard Wakeford
Epidemiological studies of those exposed occupationally to ionising radiation offer an important opportunity to directly check the assumptions underlying the international system of radiological protection against low-level radiation exposures. Recent nuclear worker studies, notably the International Nuclear Workers Study (INWORKS) and studies of the Mayak workforce in Russia, provide powerful investigations of a wide range of cumulative photon doses received at a low dose-rate over protracted periods, and broadly confirm radiation-related excess risks of leukaemia and solid cancers at around the levels predicted by standard risk models derived mainly from the experience of the Japanese atomic-bomb survivors acutely exposed principally to gamma radiation...
June 23, 2021: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://read.qxmd.com/read/34029594/perm1-promotes-cardiomyocyte-mitochondrial-biogenesis-and-protects-against-hypoxia-reoxygenation-induced-damage-in-mice
#33
JOURNAL ARTICLE
Yoshitake Cho, Shizuko Tachibana, Kayla Lam, Yoh Arita, Shamim Khosrowjerdi, Oliver Zhang, Alex Liang, Ruixia Li, Aleksander Andreyev, Anne N Murphy, Robert S Ross
Normal contractile function of the heart depends on a constant and reliable production of ATP by cardiomyocytes. Dysregulation of cardiac energy metabolism can result in immature heart development and disrupt the ability of the adult myocardium to adapt to stress, potentially leading to heart failure. Further, restoration of abnormal mitochondrial function can have beneficial effects on cardiac dysfunction. Previously, we identified a novel protein termed Perm1 (PGC-1 and ERR induced regulator, muscle 1) that is enriched in skeletal and cardiac-muscle mitochondria and transcriptionally regulated by PGC-1 (Peroxisome proliferator-activated receptor gamma coactivator 1) and ERR (Estrogen-related receptor)...
May 21, 2021: Journal of Biological Chemistry
https://read.qxmd.com/read/33668521/long-term-effects-of-very-low-dose-particle-radiation-on-gene-expression-in-the-heart-degenerative-disease-risks
#34
JOURNAL ARTICLE
Venkata Naga Srikanth Garikipati, Arsen Arakelyan, Eleanor A Blakely, Polly Y Chang, May M Truongcao, Maria Cimini, Vandana Malaredy, Anamika Bajpai, Sankar Addya, Malik Bisserier, Agnieszka Brojakowska, Abrisham Eskandari, Mary K Khlgatian, Lahouaria Hadri, Kenneth M Fish, Raj Kishore, David A Goukassian
Compared to low doses of gamma irradiation (γ-IR), high-charge-and-energy (HZE) particle IR may have different biological response thresholds in cardiac tissue at lower doses, and these effects may be IR type and dose dependent. Three- to four-month-old female CB6F1/Hsd mice were exposed once to one of four different doses of the following types of radiation: γ-IR 137 Cs (40-160 cGy, 0.662 MeV), 14 Si-IR (4-32 cGy, 260 MeV/n), or 22 Ti-IR (3-26 cGy, 1 GeV/n). At 16 months post-exposure, animals were sacrificed and hearts were harvested and archived as part of the NASA Space Radiation Tissue Sharing Forum...
February 13, 2021: Cells
https://read.qxmd.com/read/33612179/cancer-incidence-risks-above-and-below-1-gy-for-radiation-protection-in-space
#35
JOURNAL ARTICLE
Luana Hafner, Linda Walsh, Uwe Schneider
The risk assessment quantities called lifetime attributable risk (LAR) and risk of exposure-induced cancer (REIC) are used to calculate the cumulative cancer incidence risks for astronauts, attributable to radiation exposure accumulated during long term lunar and Mars missions. These risk quantities are based on the most recently published epidemiological data on the Life Span Study (LSS) of Japanese A-bomb survivors, who were exposed to γ-rays and neutrons. In order to analyze the impact of a different neutron RBE on the risk quantities, a model for the neutron relative biological effectiveness (RBE) relative to gammas in the LSS is developed based on an older dataset with less follow-up time...
February 2021: Life Sciences in Space Research
https://read.qxmd.com/read/33471905/lung-cancer-in-the-mayak-workers-cohort-risk-estimation-and-uncertainty-analysis
#36
JOURNAL ARTICLE
Daniel O Stram, Mikhail Sokolnikov, Bruce A Napier, Vadim V Vostrotin, Alexander Efimov, Dale L Preston
The workers at the Mayak nuclear facility near Ozyorsk, Russia are a primary source of information about exposure to radiation at low-dose rates, since they were subject to protracted exposures to external gamma rays and to internal exposures from plutonium inhalation. Here we re-examine lung cancer mortality rates and assess the effects of external gamma and internal plutonium exposures using recently developed Monte Carlo dosimetry systems. Using individual lagged mean annual lung doses computed from the dose realizations, we fit excess relative risk (ERR) models to the lung cancer mortality data for the Mayak Workers Cohort using risk-modeling software...
January 20, 2021: Radiation Research
https://read.qxmd.com/read/33389049/risk-of-skin-cancer-by-histological-type-in-a-cohort-of-workers-chronically-exposed-to-ionizing-radiation
#37
JOURNAL ARTICLE
Tamara V Azizova, Maria V Bannikova, Evgeniya S Grigoryeva, Valentina L Rybkina
The incidence risk of non-melanoma skin cancer (NMSC), in particular basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), was investigated in a cohort of workers of the Russian nuclear facility, the Mayak Production Association (PA), who had been occupationally exposed to low dose-rate ionizing radiation over prolonged periods. The study cohort included all workers who had been hired at the enterprise in 1948-1982 and followed up to 31.12.2018 (22,377 individuals, 25% of females). The mean cumulative skin absorbed dose of external gamma-ray exposure was 0...
January 3, 2021: Radiation and Environmental Biophysics
https://read.qxmd.com/read/32294114/risk-of-stomach-cancer-incidence-in-a-cohort-of-mayak-pa-workers-occupationally-exposed-to-ionizing-radiation
#38
JOURNAL ARTICLE
Galina V Zhuntova, Tamara V Azizova, Evgeniya S Grigoryeva
Stomach cancer is a widespread health condition associated with environmental and genetic factors. Contribution of ionizing radiation to stomach cancer etiology is not sufficiently studied. This study was aimed to assess an association of the stomach cancer incidence risk with doses from occupational radiation exposure in a cohort of workers hired at main Mayak production association facilities in 1948-1982 taking into account non-radiation factors including digestive disorders. The study cohort comprised 22,377 individuals and by 31...
2020: PloS One
https://read.qxmd.com/read/31730422/standardized-siegesbeckia-orientalis-l-extract-increases-exercise-endurance-through-stimulation-of-mitochondrial-biogenesis
#39
JOURNAL ARTICLE
Mi-Bo Kim, Changhee Kim, Jae-Kwan Hwang
Siegesbeckia orientalis has been reported to exhibit anti-allergic, anti-infertility, anti-inflammatory, anti-rheumatic, and immunosuppressive activities. However, there are very few studies describing its stimulatory effects on exercise capacity. This study elucidated whether S. orientalis extract (SOE) standardized to kirenol content can enhance exercise endurance by increasing mitochondrial biogenesis. SOE significantly improved the running distance and time in mice fed normal diet (ND) and high-fat diet (HFD)...
November 2019: Journal of Medicinal Food
https://read.qxmd.com/read/31589602/dynamic-enhancers-control-skeletal-muscle-identity-and-reprogramming
#40
JOURNAL ARTICLE
Krithika Ramachandran, Madhavi D Senagolage, Meredith A Sommars, Christopher R Futtner, Yasuhiro Omura, Amanda L Allred, Grant D Barish
Skeletal muscles consist of fibers of differing metabolic activities and contractility, which become remodeled in response to chronic exercise, but the epigenomic basis for muscle identity and adaptation remains poorly understood. Here, we used chromatin immunoprecipitation sequencing of dimethylated histone 3 lysine 4 and acetylated histone 3 lysine 27 as well as transposase-accessible chromatin profiling to dissect cis-regulatory networks across muscle groups. We demonstrate that in vivo enhancers specify muscles in accordance with myofiber composition, show little resemblance to cultured myotube enhancers, and identify glycolytic and oxidative muscle-specific regulators...
October 2019: PLoS Biology
keyword
keyword
21078
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.