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Respiratory medicine

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https://www.readbyqxmd.com/read/29933248/multivariate-assessment-of-the-central-cardiorespiratory-network-structure-in-neuropathological-disease
#1
Steffen Schulz, Jens Haueisen, Karl-Juergen Bär, Andreas Voss

 The new interdisciplinary field of network physiology is getting more and more into the focus of interest in medicine. The autonomic nervous system (ANS) dysfunction is well described in schizophrenia (SZO). However, the linear and nonlinear coupling between the ANS and central nervous system (CNS) is only partly addressed until now. This coupling can be assumed as a feedback-feedforward network, reacting with flexible and adaptive responses to internal and external factors.
 Approach:
 For the first time, in this study, we investigated linear and nonlinear short-term central-cardiorespiratory couplings of 17 patients suffering from paranoid schizophrenia (SZO) in comparison to 17 age-gender matched healthy subjects (CON) analyzing heart rate (HR), respiration (RESP) and the power of frontal EEG activity (PEEG)...
June 22, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29933014/new-insights-on-the-anti-inflammatory-potential-and-safety-profile-of-thymus-carnosus-and-thymus-camphoratus-essential-oils-and-their-main-compounds
#2
Mónica Zuzarte, Jorge M Alves-Silva, Melissa Alves, Carlos Cavaleiro, Lígia Salgueiro, Maria Teresa Cruz
ETHNOPHARMACOLOGICAL RELEVANCE: Thymus camphoratus and T. carnosus are widely used in Portugal for the treatment of inflammatory-related conditions, such as inflammation of the respiratory tract, being the later also used as an antitussive. AIM OF THE STUDY: Bearing in mind the lack of scientific studies focused on the pharmacological activity of Thymus camphoratus and T. carnosus, this work was designed to validate the anti-inflammatory properties ascribed to these traditional species and concomitantly to unveil both the putative molecular mechanisms behind their bioactivity as well as the safety profile of their essential oils and major compounds...
June 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29932044/optimization-of-antimicrobial-treatment-to-minimize-resistance-selection
#3
Luca Guardabassi, Mike Apley, John Elmerdahl Olsen, Pierre-Louis Toutain, Scott Weese
Optimization of antimicrobial treatment is a cornerstone in the fight against antimicrobial resistance. Various national and international authorities and professional veterinary and farming associations have released generic guidelines on prudent antimicrobial use in animals. However, these generic guidelines need to be translated into a set of animal species- and disease-specific practice recommendations. This article focuses on prevention of antimicrobial resistance and its complex relationship with treatment efficacy, highlighting key situations where the current antimicrobial drug products, treatment recommendations, and practices may be insufficient to minimize antimicrobial selection...
May 2018: Microbiology Spectrum
https://www.readbyqxmd.com/read/29929519/prescription-patterns-of-traditional-chinese-medicine-amongst-taiwanese-children-a-population-based-cohort-study
#4
Hwey-Fang Liang, Yao-Hsu Yang, Pau-Chung Chen, Hsing-Chun Kuo, Chia-Hao Chang, Ying-Hsiang Wang, Kuang-Ming Wu
BACKGROUND: Traditional Chinese medicine (TCM) has been used by Chinese patients and in many other countries worldwide. However, epidemiological reports and prescription patterns on children are few. METHODS: A cohort of 178,617 children aged 18 and under from one million randomly sampled cases of the National Health Insurance Research Database was analyzed for TCM prescription patterns. SAS 9.1 was applied and descriptive medicine utilization patterns were presented...
June 22, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29929357/bee-venom-stimulation-into-lung-meridian-acupoint-reduces-inflammation-in-a-mouse-model-of-carrageenan-induced-pleurisy-an-alternative-therapeutic-approach-for-the-respiratory-inflammatory-disease
#5
Hoon-Seong Choi, Suk-Yun Kang, Dae-Hyun Roh, Sheu-Ran Choi, Yeonhee Ryu, Jang-Hern Lee
Respiratory inflammation is frequent and fatal pathologic state encountered in veterinary medicine. Although diluted bee venom (dBV) has potent anti-inflammatory effects, the clinical use of dBV is limited to several chronic inflammatory diseases. The present study was designed to propose the acupoint treatment of dBV as a novel therapeutic strategy for respiratory inflammatory disease. Experimental pleurisy was induced by injection of carrageenan into left pleural space in mouse. dBV was injected into a specific lung meridian acupoint (LU-5) or into arbitrary non-acupoint located near the midline of the back in mouse...
June 21, 2018: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29928982/heterogeneity-and-the-origins-of-asthma
#6
REVIEW
Rebecca Scherzer, Mitchell H Grayson
OBJECTIVE: It is a well-known fact that there is significant heterogeneity in the origins of asthma in adults and children. This article examines the roots of asthma across the ages including atopy, the role of the microbiome and viral infections, along with comorbidities/confounders such as obesity, aspirin-exacerbated respiratory disease (AERD), neutrophilic asthma, cigarette smoking and the possibility of an asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome. DATA SOURCES: Data was taken from various scientific search engines including PubMed and Science Direct databases...
June 18, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29925128/-comparative-study-on-deep-venous-thrombosis-onset-in-hospitalized-patients-with-different-underlying-diseases
#7
M L Sun, X H Wang, J Huang, J Wang, Y Wang
Objective: To improve the understanding of deep venous thrombosis (DVT), the present study was conducted to investigate the difference of DVT onset in hospitalized patients with different underlying diseases. Methods: This is a single-center retrospective study from Beijing Shijitan Hospital. Clinical data from hospital onset DVT patients from 2007 to 2016 were collected. DVT was confirmed with compression ultrasonography (CUS), color Doppler flow imaging (CDFI), CT venography (CTV), magnetic resonance venography (MRV), lower extremities radionuclide venography(RDV) or conventional venography (CV)...
June 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29924044/pulmonary-hemangioma-mimicking-bronchiectasis-a-case-report
#8
Wei Li, Tong Xin, Yuxin Hu, Peng Gao, Mo Chen, Jie Zhang
RATIONALE: Pulmonary hemangioma is a rare thoracic condition that can lead to hemoptysis. Here we report a case that presented with lumen dilatation suggestive of bronchiectasis on high-resolution computed tomography (CT) and was misdiagnosed as bronchiectasis for more than 10 years. PATIENT CONCERNS: A 41-year-old female patient was admitted to the Department of Respiratory Medicine due to hemoptysis. DIAGNOSES: The patient was misdiagnosed as having bronchiectasis for more than 10 years...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923972/rapid-detection-of-mycoplasma-pneumoniae-by-loop-mediated-isothermal-amplification-assay
#9
Xin Yuan, Changqing Bai, Qian Cui, Han Zhang, Jing Yuan, Kaiwen Niu, Yuzhong Feng, Xin Jin, Puyuan Li, Huiying Liu
To improve the diagnosis and treatment of Mycoplasma pneumoniae (Mp) infection and reduce the misuse of antibiotics, we sought to establish a loop-mediated isothermal amplification (LAMP) assay for rapid detection of Mp.Six primers specific for the Mp P1 gene were designed, and the LAMP method was used to rapidly detect Mp. The sensitivity of the LAMP method was determined by serial dilution of the standard Mp strain FH (standard strains of Mycoplasma pneumoniae). Specificity was assessed with 17 common pathogenic microorganisms in the respiratory tract...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29922730/non-invasive-ventilation-in-the-ed-whom-when-how
#10
REVIEW
Erkan Göksu, Deniz Kılıç, Süleyman İbze
As emergency physicians, we encounter patients suffering from either hypoxemic and/or hypercarbic respiratory problems on a daily basis. A stepwise approach to solving this problem seems logical from an emergency medicine perspective. Current literature supports the notion that NIV decreases endotracheal intubation rates and, mortality in select patient populations. The key to the success of NIV is patient cooperation and support for the care givers. In this narrative review, non-invasive ventilation (NIV) is discussed in terms of modes of delivery, interface and patient selection, as well as practical considerations...
June 2018: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29920955/nimotuzumab-combined-with-chemotherapy-as-first-line-treatment-for-advanced-lung-squamous-cell-carcinoma
#11
Xiaoyan Si, Shafei Wu, Hanping Wang, Xiaotong Zhang, Mengzhao Wang, Xuan Zeng, Li Zhang
BACKGROUND: This study was conducted to evaluate the efficacy and safety of nimotuzumab combined with chemotherapy as first-line therapy in advanced lung squamous cell carcinoma (LSCC), and to explore predictive biomarkers of the efficacy of nimotuzumab. METHODS: A retrospective study was conducted of patients with advanced LSCC administered nimotuzumab combined with chemotherapy as first-line therapy from June 2012 to December 2016 at the Department of Respiratory Medicine, Peking Union Medical College Hospital...
June 19, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29916581/-immunological-mechanisms-of-allergic-diseases
#12
Enrico Maggi
OBJECTIVES: In the last decades the knowledge on pathogenetic mechanisms of allergic diseases extraordinarily improved with relevant clinical outputs. From the '90yrs we know that Th2 cells are essential for allergic inflammation, since they produce type 2 cytokines, recognise allergens, induce IgE switch on B cells and recruit mastcells and eosinophils into tissues for maintaining the flogosis. METHODS: Recently a new subset of innate immunity (ILC2) have been shown to amplify the allergic inflammation...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29915536/use-of-submicron-vaterite-particles-serves-as-an-effective-delivery-vehicle-to-the-respiratory-portion-of-the-lung
#13
Olga Gusliakova, Elena N Atochina-Vasserman, Olga Sindeeva, Sergey Sindeev, Sergey Pinyaev, Nikolay Pyataev, Viktor Revin, Gleb B Sukhorukov, Dmitry Gorin, Andrew J Gow
Nano- and microencapsulation has proven to be a useful technique for the construction of drug delivery vehicles for use in vascular medicine. However, the possibility of using these techniques within the lung as an inhalation delivery mechanism has not been previously considered. A critical element of particle delivery to the lung is the degree of penetrance that can be achieved with respect to the airway tree. In this study we examined the effectiveness of near infrared (NIR) dye (Cy7) labeled calcium carbonate (vaterite) particles of 3...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29913300/the-genus-pterocaulon-asteraceae-a-review-on-traditional-medicinal-uses-chemical-constituents-and-biological-properties
#14
REVIEW
Bruna Medeiros-Neves, Helder Ferreira Teixeira, Gilsane Lino von Poser
ETHNOPHARMACOLOGICAL RELEVANCE: Species of the genus Pterocaulon (Asteraceae) are used in different parts of the world for mainly to treat skin and liver diseases, as well as disorders of the respiratory system, among others. AIM OF THE STUDY: This review aims to discuss the present state of the art concerning the ethnobotanical uses, secondary metabolites and biological effects of Pterocaulon species and their chemical components. MATERIALS AND METHODS: The available information on the genus Pterocaulon was gathered from scientific databases (Web of Science, Pubmed, ScienceDirect, Scopus, ChemSpider, SciFinder ACS Publications, Wiley Online Library)...
June 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29912110/understanding-macrophages-in-acute-respiratory-distress-syndrome-from-pathophysiology-to-precision-medicine
#15
Jean-Michel Constantin, Thomas Godet, Matthieu Jabaudon
No abstract text is available yet for this article.
July 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29910741/physiology-and-pathophysiology-in-ultra-marathon-running
#16
REVIEW
Beat Knechtle, Pantelis T Nikolaidis
In this overview, we summarize the findings of the literature with regards to physiology and pathophysiology of ultra-marathon running. The number of ultra-marathon races and the number of official finishers considerably increased in the last decades especially due to the increased number of female and age-group runners. A typical ultra-marathoner is male, married, well-educated, and ~45 years old. Female ultra-marathoners account for ~20% of the total number of finishers. Ultra-marathoners are older and have a larger weekly training volume, but run more slowly during training compared to marathoners...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29904594/towards-precision-medicine-the-application-of-omics-technologies-in-asthma-management
#17
Chiara Scelfo, Carla Galeone, Francesca Bertolini, Marco Caminati, Patrizia Ruggiero, Nicola Facciolongo, Francesco Menzella
Asthma is a chronic obstructive respiratory disease characterised by bronchial inflammation. Its biological and clinical features have been widely explored and a number of pharmacological treatments are currently available. Currently several aspects of asthma pathophysiological background remain unclear, and this is crucial for the traditional asthma phenotype approach as well as for new endotype definition. In this scenario, the identification of new molecular and clinical biomarkers may be helpful in order to better understand the disease, define specific diagnostic tools and highlight relevant novel targets for pharmacology treatments...
2018: F1000Research
https://www.readbyqxmd.com/read/29903754/review-of-the-british-thoracic-society-winter-meeting-2017-6-8-december-2017-london-uk
#18
Aran Singanayagam, Hannah V Woodcock, Philip L Molyneaux, Gisli Jenkins
This article reviews the British Thoracic Society Winter Meeting 2017 and summarises the new developments in scientific and clinical research across the breadth of respiratory medicine. The article discusses a number of symposia and selected abstract presentations from the meeting.
June 14, 2018: Thorax
https://www.readbyqxmd.com/read/29903607/improvement-of-physical-activity-in-chronic-obstructive-pulmonary-disease-by-pulmonary-rehabilitation-and-pharmacological-treatment
#19
REVIEW
Takanobu Shioya, Susumu Sato, Masahiro Iwakura, Hitomi Takahashi, Yoshino Terui, Sachiko Uemura, Masahiro Satake
Physical activity (PA) is defined as bodily movement produced by skeletal muscles with energy expenditure beyond resting levels. PA is closely related to reduced morbidity and mortality in chronic obstructive pulmonary disease (COPD). Self-report questionnaires are often subject to recall bias, correlating poorly with objectively qualified PA, and do not provide an accurate estimate of free-living energy expenditure. PA may be objectively evaluated by newly developed tri-axial accelerometers by quantifying steps or body movements over a period of time...
June 11, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29903008/immunomodulatory-properties-of-quercetin-3-o-%C3%AE-l-rhamnopyranoside-from-rapanea-melanophloeos-against-influenza-a-virus
#20
Parvaneh Mehrbod, Muna Ali Abdalla, Fatemeh Fotouhi, Masoumeh Heidarzadeh, Abimbola O Aro, Jacobus N Eloff, Lyndy J McGaw, Folorunso O Fasina
BACKGROUND: Influenza infection is a major public health threat. The role of influenza A virus-induced inflammatory response in severe cases of this disease is widely recognized. Drug resistance and side effects of chemical treatments have been observed, resulting in increased interest in alternative use of herbal medications for prophylaxis against this infection. The South African medicinal plant, Rapanea melanophloeos (RM) (L.) Mez of the family Myrsinaceae was selected owing to its traditional use for the treatment of several diseases such as respiratory ailments and also previous preliminary studies of anti-influenza activity of its methanolic extract...
June 15, 2018: BMC Complementary and Alternative Medicine
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