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https://www.readbyqxmd.com/read/29474356/management-of-severe-strongyloidiasis-attended-at-reference-centers-in-spain
#1
Angela Martinez-Perez, Silvia Roure Díez, Moncef Belhasen-Garcia, Diego Torrús-Tendero, Jose Luis Perez-Arellano, Teresa Cabezas, Cristina Soler, Marta Díaz-Menéndez, Miriam Navarro, Begoña Treviño, Fernando Salvador-Vélez
INTRODUCTION: Strongyloides stercoralis is a globally distributed nematode that causes diverse clinical symptoms in humans. Spain, once considered an endemic country, has experienced a recent increase in imported cases. The introduction of serology helps diagnosis and is currently replacing microbiological techniques in some settings, but its sensitivity is variable and can be low in immunocompromised patients. Diagnosis can only be confirmed by identification of larvae. Often, this "gold standard" can only be achieved in severe cases, such as disseminated S...
February 23, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29473978/distinction-between-rhinovirus-induced-acute-asthma-and-asthma-augmented-influenza-infection
#2
George V Guibas, Maria Tsolia, Ioannis Christodoulou, Fotini Stripeli, Zoi Sakkou, Nikolaos G Papadopoulos
BACKGROUND: Rhinovirus (RV) is an established trigger of asthma attacks, whereas such a link is less consistent for influenza virus (IFV). OBJECTIVE: In the context of precision medicine, we hypothesized that IFV infection may cause a condition essentially different from RV, and we investigated this by evaluating clinical characteristics of RV/IFV-positive and -negative children with respiratory symptoms and/or fever. METHODS: 1207 children, 6-months to 13-years old, hospitalized for flu-like illness were recruited in this cross-sectional study...
February 23, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29471085/houttuynia-cordata-polysaccharides-ameliorate-pneumonia-severity-and-intestinal-injury-in-mice-with-influenza-virus-infection
#3
Haiyan Zhu, Xiaoxiao Lu, Lijun Ling, Hong Li, Yingye Ou, Xunlong Shi, Yan Lu, Yunyi Zhang, Daofeng Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Hottuynia cordata is an important traditional Chinese medicine for the treatment of respiratory diseases including bacterial and viral infections. Polysaccharides isolated from Houttuynia cordata (HCP), as its main ingredients, have been demonstrated to ameliorate the LPS-induced acute lung injury in mice. The study aimed to determine the protective effects of HCP on multiple organ injury in influenza A virus (IAV) H1N1 infected mice and its primary mechanisms in anti-inflammation and immune regulation...
February 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29468052/prevalence-of-staphylococcus-spp-nasal-colonization-among-doctors-of-podiatric-medicine-and-associated-risk-factors-in-spain
#4
Sheila de Benito, Luis Alou, Ricardo Becerro-de-Bengoa-Vallejo, Marta Elena Losa-Iglesias, María Luisa Gómez-Lus, Luis Collado, David Sevillano
Background: This study aimed to estimate the prevalence of methicillin-susceptible and -resistant Staphylococcus aureus (MSSA and MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) nasopharyngeal carriage among Doctors of Podiatric Medicine (Podiatrists) and to determine the potential risk factors. Methods: A cross-sectional study was carried out in 2016-2017 among 239 podiatrists in Spain. The presence of MSSA, MRSA, and MRSE was determined by microbiological analysis of nasal exudate and antimicrobial susceptibility was determined...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29458701/impact-of-arterial-stiffness-on-watchpat-variables-in-patients-with-obstructive-sleep-apnea
#5
Taku Kinoshita, Misuzu Yahaba, Jiro Terada, Takuma Matsumura, Yoriko Sakurai, Kengo Nagashima, Seiichiro Sakao, Koichiro Tatsumi
STUDY OBJECTIVES: The WatchPAT is a wrist-worn portable device that creates integration data regarding peripheral arterial tone (PAT), oxyhemoglobin saturation, heart rate, and actigraphy to diagnose or screen for obstructive sleep apnea (OSA). Previous studies have demonstrated the efficacy and validity of respiratory variables measured by the WatchPAT compared to those using polysomnography (PSG). However, the effects of arterial stiffness or atherosclerosis on WatchPAT parameters remain to be elucidated...
February 13, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29458696/characterization-of-respiratory-events-in-obstructive-sleep-apnea-using-suprasternal-pressure-monitoring
#6
Martin Glos, AbdelKebir Sabil, Katharina Sophie Jelavic, Christoph Schöbel, Ingo Fietze, Thomas Penzel
STUDY OBJECTIVES: In obstructive sleep apnea (OSA) esophageal pressure (Pes) is the gold standard for measurement of respiratory effort, and respiratory inductance plethysmography (RIP) is considered an accepted measurement technique. However, the use of RIP could lead to limited accuracy in certain cases and therefore suprasternal pressure (SSP) monitoring might improve the reliability of OSA diagnosis. We aimed to use SSP for the visual characterization of respiratory events in adults and compared results to those obtained by RIP from polysomnography (PSG)...
February 13, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29456676/-cordyceps-sinensis-inhibits-airway-remodeling-in-rats-with-chronic-obstructive-pulmonary-disease
#7
Lei Yang, Xingai Jiao, Jinxiang Wu, Jiping Zhao, Tian Liu, Jianfeng Xu, Xiaohui Ma, Liuzao Cao, Lin Liu, Yahui Liu, Jingyu Chi, Minfang Zou, Shuo Li, Jiawei Xu, Liang Dong
Cordyceps sinensis is a traditional Chinese herbal medicine that has been used for centuries in Asia as a tonic to soothe the lung for the treatment of respiratory diseases. The aim of the present study was to determine the effects of C. sinensi s on airway remodeling in chronic obstructive pulmonary disease (COPD) and investigate the underlying molecular mechanisms. Rats with COPD were orally administered C. sinensis at low, moderate or high doses (2.5, 5 or 7.5 g/kg/day, respectively) for 12 weeks. Airway tissue histopathology, lung inflammation and airway remodeling were evaluated...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29454509/group-c-strep-mediastinitis-a-case-report
#8
Joseph G Kotora, Eric J Schmieler, Christian S McEvoy, Stephen L Noble
This case is significant to the practice of emergency medicine because it represents the development of an uncommon and potentially fatal mediastinal infection from a commonly encountered and appropriately treated community respiratory pathogen. Most published reports on mediastinitis are those that are status-post cardiothoracic surgery. In our report, we discuss a case of a healthy, young individual who developed this morbid entity from extension of a simple respiratory infection where Group C Streptococcus has been isolated as the causative organism, which to our knowledge has not been previously reported...
February 3, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29452743/medication-wasted-contents-and-costs-of-medicines-ending-up-in-household-garbage
#9
Sabine Vogler, Roger H P F de Rooij
BACKGROUND: Despite potentially considerable implications for public health, the environment and public funds, medicine waste is an under-researched topic. This study aims to analyse medicines drawn from household garbage in Vienna (Austria) and to assess possible financial implications for public payers. METHODS: Four pharmaceutical waste samples collected by the Vienna Municipal Waste Department between April 2015 and January 2016 were investigated with regard to their content...
February 10, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29451901/the-novel-antibiotic-rhodomyrtone-traps-membrane-proteins-in-vesicles-with-increased-fluidity
#10
Dennapa Saeloh, Varomyalin Tipmanee, Kin Ki Jim, Marien P Dekker, Wilbert Bitter, Supayang P Voravuthikunchai, Michaela Wenzel, Leendert W Hamoen
The acylphloroglucinol rhodomyrtone is a promising new antibiotic isolated from the rose myrtle Rhodomyrtus tomentosa, a plant used in Asian traditional medicine. While many studies have demonstrated its antibacterial potential in a variety of clinical applications, very little is known about the mechanism of action of rhodomyrtone. Preceding studies have been focused on intracellular targets, but no specific intracellular protein could be confirmed as main target. Using live cell, high-resolution, and electron microscopy we demonstrate that rhodomyrtone causes large membrane invaginations with a dramatic increase in fluidity, which attract a broad range of membrane proteins...
February 16, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29451444/survival-and-prognostic-factors-in-cats-with-restrictive-cardiomyopathy-a-review-of-90-cases
#11
Chiara Locatelli, Danitza Pradelli, Giulia Campo, Ilaria Spalla, Alice Savarese, Paola G Brambilla, Claudio Bussadori
Objectives Large studies focusing on restrictive cardiomyopathy (RCM) in the cat are scarce. The aims of this retrospective study were to describe epidemiological characteristics and to analyse prognostic factors affecting survival in cats with RCM. Methods The clinical archives of the Gran Sasso Veterinary Clinic (Milan, Italy) and of the cardiology unit of the Department of Veterinary Medicine (University of Milan, Italy) from 1997-2015 were reviewed for all cats diagnosed with RCM based on an echocardiographic examination (left atrial/bi-atrial enlargement, normal left ventricle wall thickness, normal or mildly decreased systolic function and restrictive left ventricle filling pattern with pulsed Doppler echocardiography)...
February 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29447055/advanced-microengineered-lung-models-for-translational-drug-discovery
#12
Brian F Niemeyer, Peng Zhao, Rubin M Tuder, Kambez H Benam
Lung diseases impose a significant socioeconomic burden and are a leading cause of morbidity and mortality worldwide. Moreover, respiratory medicine, unlike several other therapeutic areas, faces a disappointingly low number of new approved therapies. This is partly due to lack of reliable in vitro or in vivo models that can reproduce organ-level complexity and pathophysiological responses of human lung. Here, we examine new opportunities in application of recently emerged organ-on-chip technology to model human lung alveolus and small airway in preclinical drug development and biomarker discovery...
February 1, 2018: SLAS Discovery
https://www.readbyqxmd.com/read/29443448/an-intraneural-electrode-for-bioelectronic-medicines-for-treatment-of-hypertension
#13
Cristian Sevcencu, Thomas N Nielsen, Johannes J Struijk
OBJECTIVES: As the left vagus nerve (LVN) mediates a baroreflex blood pressure (BP) decrease, LVN stimulation (LVNS) could be a therapy for hypertension. Moreover, LVNS could elegantly be adjusted to the patient's actual BP and physical activity by using the neural information about BP and respiration extractable from LVN. However, unselective LVNS will trigger undesirable side-effects and therefore we here investigated the feasibility of using an intraneural electrode for extracting BP and respiration markers from the LVN and for selective LVNS...
February 14, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29442380/marketing-medicines-charting-the-rise-of-modern-therapeutics-through-a-systematic-review-of-adverts-in-uk-medical-journals-1950-1980
#14
REVIEW
A Richard Green, Peter M Haddad, Jeffrey K Aronson
AIMS: To examine how pharmaceutical products that were first marketed between 1950 and 1980 were promoted to physicians through advertisements and briefly review advertising regulations and accuracy of the advertisements in the light of modern knowledge. METHODS: We systematically reviewed advertisements promoting drugs for specific therapeutic areas, namely central nervous system disorders (anxiety and sleep disorders, depression, psychoses, and Parkinson's disease), respiratory disorders, cardiovascular disorders, and gastrointestinal disorders...
February 14, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29439264/innate-immunity-of-the-lung-from-basic-mechanisms-to-translational-medicine
#15
Dominik Hartl, Rabindra Tirouvanziam, Julie Laval, Catherine M Greene, David Habiel, Lokesh Sharma, Ali Önder Yildirim, Charles S Dela Cruz, Cory M Hogaboam
The respiratory tract is faced daily with 10,000 L of inhaled air. While the majority of air contains harmless environmental components, the pulmonary immune system also has to cope with harmful microbial or sterile threats and react rapidly to protect the host at this intimate barrier zone. The airways are endowed with a broad armamentarium of cellular and humoral host defense mechanisms, most of which belong to the innate arm of the immune system. The complex interplay between resident and infiltrating immune cells and secreted innate immune proteins shapes the outcome of host-pathogen, host-allergen, and host-particle interactions within the mucosal airway compartment...
February 13, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29436567/asthma-prevalence-among-adults-in-saudi-arabia
#16
Mohammed O Al Ghobain, Saleh S Algazlan, Talal M Oreibi
OBJECTIVES: To investigate asthma prevalence and to measure asthma symptoms among Saudi adults in Riyadh, Kingdom of Saudi Arabia. METHODS: A cross-sectional survey using the European Community Respiratory Health Survey (ECRHS)questionnaire carried out between April and June 2016, among male and female Saudi nationals aged 20-44 years living in Riyadh. Disproportionate cluster sampling method was used. Asthma was defined based on answering "yes" to any of the following: Have you had wheezing when you did not have a cold in the last 12 months? Have you been told by a physician to have asthma? Are you taking medicine for asthma? RESULTS: A total of 2,405 participants completed the survey...
February 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29436404/from-systems-biology-to-p4-medicine-applications-in-respiratory-medicine
#17
Guillaume Noell, Rosa Faner, Alvar Agustí
Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the potential to understand these emergent properties holistically. It stems from advancements in medical diagnostics, "omics" data and bioinformatic computing power. It paves the way forward towards "P4 medicine" (predictive, preventive, personalised and participatory), which seeks to better intervene preventively to preserve health or therapeutically to cure diseases...
March 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29433729/revolution-in-respiratory-medicine
#18
EDITORIAL
Ali I Musani
No abstract text is available yet for this article.
March 2018: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/29431136/how-patients-experiences-of-respiratory-tract-infections-affect-healthcare-seeking-and-antibiotic-use-insights-from-a-cross-sectional-survey-in-rural-anhui-china
#19
Mengjie Diao, Xingrong Shen, Jing Cheng, Jing Chai, Rui Feng, Panpan Zhang, Rongyao Zhou, Helen Lambert, Debin Wang
OBJECTIVE: To investigate the occurrence of reported respiratory tract infection (RTI) symptoms and their effects on use of self and professional care among patients in the community. DESIGN: A cross-sectional retrospective household survey. SETTING: 12 administrative villages from rural Anhui, China. PARTICIPANTS: 2160 rural adult residents aged ≥18 years registered as rural residents and actually living in the sampled villages when this study was conducted...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29428578/treatment-practices-of-households-and-antibiotic-dispensing-in-medicine-outlets-in-developing-countries-the-case-of-ghana
#20
Mary-Anne Ahiabu, Pascal Magnussen, Ib Christian Bygbjerg, Britt Pinkowski Tersbøl
INTRODUCTION: Antibiotic resistance, associated with inappropriate drug use, is a global public health threat. The pharmaceutical sectors in developing countries are poorly regulated leading to antibiotic sales and use without a prescription. The study documents the treatment of acute illnesses in households and the antibiotic dispensing practices of medicine sales outlets in Eastern region, Ghana. METHOD: Twice-weekly illness recall visits were made to 12 households in three rural communities over eight consecutive weeks...
February 7, 2018: Research in Social & Administrative Pharmacy: RSAP
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