keyword
https://read.qxmd.com/read/38508770/the-interaction-effect-of-dietary-selenium-intake-and-the-il10-rs1800871-polymorphism-on-the-risk-of-colorectal-cancer-a-case%C3%A2-control-study-in-korea
#21
JOURNAL ARTICLE
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
The importance of selenium in human health has received much attention due to its antioxidant properties when it is consumed at an appropriate level. However, the existing evidence is limited to obtain an effective conclusion for colorectal cancer (CRC). Notably, an adequate intake of selenium was reported for Koreans. Furthermore, cytokine secretion and immune function may be affected by dietary selenium. Our study aimed to explore whether selenium potentially reduces CRC risk and whether the IL10 rs1800871 polymorphism has an effect on this association...
March 21, 2024: British Journal of Nutrition
https://read.qxmd.com/read/38508282/one-pot-sustainable-synthesis-of-glucosylglycerate-from-starch-and-glycerol-through-artificial-in-vitro-enzymatic-cascade
#22
JOURNAL ARTICLE
Juanjuan Liu, Mengfei Ren, Haoran Ma, Huilin Zhang, Xinyu Cui, Runyuan Kang, Xinming Feng, Dongdong Meng
Glucosylglycerate (R-2-O-α-D-glucopyranosyl-glycerate, GG) is a negatively charged compatible solution with versatile functions. Here, an artificial in vitro enzymatic cascade was designed to feasibly and sustainably produce GG from affordable starch and glycerol. First, Spirochaeta thermophila glucosylglycerate phosphorylase (GGP) was carefully selected because of its excellent heterologous expression, specific activity, and thermostability. The optimized two-enzyme cascade, consisting of alpha-glucan phosphorylase (αGP) and GGP, achieved a remarkable 81 % conversion rate from maltodextrin and D-glycerate...
March 18, 2024: Bioresource Technology
https://read.qxmd.com/read/38507036/the-effect-of-polymorphisms-and-other-biomarkers-on-infliximab-exposure-in-paediatric-inflammatory-bowel-disease-development-of-a-population-pharmacokinetic-model
#23
JOURNAL ARTICLE
Susana Clemente-Bautista, Iñaki F Trocóniz, Óscar Segarra-Cantón, Sara Salvador-Marín, Carlos J Parramón-Teixidó, Marina Álvarez-Beltrán, Luís A López-Fernández, Helena Colom, Maria J Cabañas-Poy, Maria Q Gorgas-Torner, Marta Miarons
BACKGROUND: Therapeutic drug monitoring (TDM) of infliximab has been shown to be a effective strategy for inflammatory bowel disease (IBD). Population pharmacokinetic (PopPK) modeling can predict trough concentrations for individualized dosing. OBJECTIVE: The aim of this study was to develop a PopPK model of infliximab in a paediatric population with IBD, assessing the effect of single nucleotide polymorphisms (SNPs) and other biomarkers on infliximab clearance...
March 20, 2024: Paediatric Drugs
https://read.qxmd.com/read/38506871/-non-ige-mediated-food-allergy
#24
JOURNAL ARTICLE
María Isabel Rojo Gutiérrez, Diego Ballesteros González, Ana Karen Ortiz Durán
Food allergy is an immune response to proteins in food. It usually affects 8% of children and 2% of adults in Western countries. Non-IgE-mediated food allergy mainly affects the gastrointestinal tract. Gastrointestinal food allergies are classified, by their underlying pathogenesis, as: IgE-mediated, non-IgE-mediated, or mixed. The symptoms of patients with food protein-induced allergic proctocolitis originate from local inflammation of the distal colon, which causes hematochezia in neonates. It can affect the entire gastrointestinal tract and cause symptoms of intractable emesis, with subsequent metabolic disorders and hypovolemic shock...
December 31, 2023: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://read.qxmd.com/read/38506744/estimate-gaps-of-montreal-protocol-regulated-potent-greenhouse-gas-hfc-152a-emissions-in-china-have-been-explained
#25
JOURNAL ARTICLE
Qianna Du, Bowei Li, Mengyue Ma, Bo Yao, Xuekun Fang
1,1-Difluoroethane (HFC-152a) is a hydrofluorocarbon regulated by the Montreal Protocol, and its emissions in China are of concern as China will regulate HFC-152a in 2024. However, no observation-inferred top-down estimates were undertaken after 2017, and substantial gaps existed among previous estimates of China's HFC-152a emissions. Using the atmospheric observations and inverse modeling, this study reveals China's HFC-152a emissions of 9.4 ± 1.7 Gg/yr (gigagrams per year), 10.6 ± 1.8 Gg/yr, and 9...
March 20, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38506378/association-of-the-esr1-rs9340799-olr1-rs3736234-lipc-rs2070895-vdr-rs2228570-and-cetp-rs708272-polymorphisms-with-risk-of-coronary-artery-disease-in-iranian-patients
#26
JOURNAL ARTICLE
Zahra Miri Karam, Abolfazl Yari, Atefeh Najmadini, Nima Norouzi Khorasani, Rezvan Attari, Saeideh Jafarinejad-Farsangi, Mohammad Ali Miri Karam, Hamid Najafipour, Kolsoum Saeidi
BACKGROUND: Coronary artery disease (CAD) is a devastating illness and a leading cause of death worldwide, primarily caused by atherosclerosis resulting from a genetic-environmental interaction. This study aimed to investigate the relationship between the ESR1 (rs9340799), OLR1 (rs3736234), LIPC (rs2070895), VDR (rs2228570), and CETP (rs708272) polymorphisms, lipid profile parameters, and CAD risk in a southeast Iranian population. METHODS: A total of 400 subjects (200 CAD patients with hyperlipidemia and 200 healthy controls) were enrolled in this case-control study...
March 20, 2024: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/38504781/association-study-of-the-polymorphisms-rs2228611-of-the-dnmt1-gene-and-rs1569686-of-the-dnmt3b-gene-with-bladder-cancer-development-in-a-sample-of-the-algerian-population
#27
JOURNAL ARTICLE
Zohra Touala-Chaila, Rym-Khadidja Abderrahmane, Slimane Kerroumi, Mostefa-Jamel Yousfi, Djebaria-Naima Meroufel, Abdallah Boudjema
Bladder cancer (BC) is a multifactorial disease with a poorly understood main cause. In this study, we aimed to evaluate the effect of the polymorphisms rs2228611 of the DNMT1 gene and rs1569686 of the DNMT3B gene on the susceptibility to develop Bladder Cancer in the Algerian population. A case-control study design was adopted, with DNA samples of 114 BC patients and 123 healthy controls. We found that the rs2228611 of the DNMT1 gene was strongly associated with an increased risk of BC development under genetic models: Codominant AG vs ...
2024: Molecular Biology Research Communications
https://read.qxmd.com/read/38504663/valuation-of-livestock-population-and-national-feed-security-to-enhance-livestock-productivity-in-ethiopia
#28
JOURNAL ARTICLE
Regasa Begna, Worku Masho
BACKGROUND: Feed is a major input in the livestock industry and covers about 60%-70% of the total cost of producing meat, milk and eggs. Inadequate feed supply in terms of quality and quantity leads to lower production performance in livestock. However, the development of an appropriate livestock production strategy through efficient utilization of existing feed resources could raise the production and per capita consumption of livestock products. Efficiency of feed resource utilization can be measured as the ratio between input to production activities and output (e...
May 2024: Veterinary Medicine and Science
https://read.qxmd.com/read/38503053/evaluation-of-different-substance-combinations-in-a-multiple-session-mesotherapy-protocol-for-the-management-of-osteoarthritis-in-dogs-a-retrospective-study
#29
JOURNAL ARTICLE
João C Alves, Ana Santos, Pilar Lafuente
OBJECTIVE: To describe the effect of different substance combinations administered through mesotherapy in dogs with hip osteoarthritis. ANIMALS: 104 dogs. METHODS: In this retrospective study, 4 groups (dogs treated with a combination of lidocaine, piroxicam, and thiocolchicoside [MG]; dogs treated with lidocaine, piroxicam, and Traumeel [TG]; dogs treated with lidocaine, piroxicam, and glucosamine [GG]; and dogs treated with the same combination as in MG combined with a photobiomodulation session [MPG]) were set...
March 19, 2024: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/38502043/association-between-pemt-rs7946-and-blood-pressure-levels-in-chinese-adolescents
#30
JOURNAL ARTICLE
Guo Ming Su, Qi Wei Guo, Yi Lin Shen, Jia Jing Cai, Xu Chen, Jia Lin, Ding Zhi Fang
OBJECTIVES: This study was to explore blood pressure levels in Chinese adolescents with different genotypes of phosphatidylethanolamine N-methyltransferase (PEMT) gene (PEMT) rs7946, as well as effects of dietary intake on blood pressure levels with different genders and different genotypes of PEMT rs7946. METHODS: PEMT rs7946 genotypes were identified by PCR-restriction fragment length polymorphism and verified by DNA sequencing. Blood pressure was measured using a standard mercury sphygmomanometer...
March 18, 2024: Blood Pressure Monitoring
https://read.qxmd.com/read/38498419/belowground-response-of-a-bahiagrass-pasture-to-long-term-elevated-co-2-and-soil-fertility-management
#31
JOURNAL ARTICLE
G Brett Runion, Stephen A Prior, H Allen Torbert
Effects of rising atmospheric CO2 concentration [CO2 ] on pastures and grazing lands are beginning to be researched, but these important systems remain understudied compared to other agronomic and forest ecosystems. Therefore, we conducted a long-term (2005-2015) study of bahiagrass ( Paspalum notatum Flüggé) response to elevated [CO2 ] and fertility management. The study was conducted at the USDA-ARS, National Soil Dynamics Laboratory open-top field chamber facility, Auburn, AL. A newly established bahiagrass pasture was exposed to either ambient or elevated (ambient + 200 µmol mol-1 ) [CO2 ]...
February 8, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38497230/role-of-raptor-gene-variants-in-hypertension-influence-on-blood-pressure-independent-of-salt-intake-in-white-population
#32
JOURNAL ARTICLE
Hayat Aljaibeji, Mahyar Heydarpour, Ana Maria Stanton, Jonathan S Williams, Luminita H Pojoga, Jose R Romero, Gordon H Williams
BACKGROUND: The mTOR (mechanistic target of rapamycin) is an essential regulator of fundamental biological processes. mTOR forms 2 distinct complexes, mTORC1 (mTOR complex 1) when it binds with RAPTOR (Regulatory-associated Protein of mTOR) and mTORC2 (mTOR complex 2) when it associates with RICTOR (Rapamycin-insesitive companion of mTOR). Due to the previous link between the mTOR pathway, aldosterone, and blood pressure (BP), we anticipated that variants in the mTOR complex might be associated with salt-sensitive BP...
March 18, 2024: Hypertension
https://read.qxmd.com/read/38497131/individual-irinotecan-therapy-under-the-guidance-of-pre-treated-ugt1a1-6-genotyping-in-gastric-cancer
#33
JOURNAL ARTICLE
Huifang Lv, Caiyun Nie, Yunduan He, Beibei Chen, Yingjun Liu, Junling Zhang, Xiaobing Chen
Background: Severe delayed diarrhea and hematological toxicity limit the use of irinotecan. Uridine diphosphate glucuronosyltransferase 1A1 ( UGT1A1 ) is a critical enzyme in irinotecan metabolism. The study aims to investigate the safety and efficacy of irinotecan under the guidance of the pre-treatment UGT1A1 genotype in the second-line treatment of gastric cancer. Methods: This study involved 110 patients. Irinotecan was injected intravenously every 3 weeks, and the dose of irinotecan was determined by polymorphism of the UGT1A1 gene, which was divided into three groups (125 mg/m2 : GG type; 100 mg/m2 : GA type; 75 mg/m2 : AA type)...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38496879/meta-analysis-investigating-the-impact-of-the-lepr-rs1137101-a-g-polymorphism-on-obesity-risk-in-asian-and-caucasian-ethnicities
#34
JOURNAL ARTICLE
Dilara Akhter Supti, Farzana Akter, Md Imranur Rahman, Md Adnan Munim, Mahafujul Islam Quadery Tonmoy, Rabia Jahan Tarin, Sumaiya Afroz, Hasan Al Reza, Roksana Yeasmin, Mohammad Rahanur Alam, Md Shahadat Hossain
Obesity is a chronic condition which is identified by the buildup of excess body fat caused by a combination of various factors, including genetic predisposition and lifestyle choices. rs1137101 (A > G) polymorphism in the CHR1 domain of LEPR protein linked to different diseases including obesity. Nevertheless, the connection between this polymorphism and the likelihood of developing obesity has not been determined definitively. Therefore, a meta-analysis was conducted to assess the relationship between rs1137101 and the risk of obesity...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496859/association-of-ox40l-gene-polymorphism-with-multiple-sclerosis-in-iranians
#35
JOURNAL ARTICLE
Abdolreza Sotoodeh Jahromi, Saiedeh Erfanian, Abazar Roustazadeh
INTRODUCTION: The exact etiology of multiple sclerosis is unknown but recent studies indicated a link between tumor necrosis factor superfamily member 4 and the disease. Polymorphisms located in the regulatory region of the gene may affect its phenotype. Hence, we aimed to investigate the association of promoter polymorphisms of the gene with multiple sclerosis and also to estimate the frequency of haplotypes in the patients and healthy subjects. METHODS: Two hundred age- and sex-matched subjects including 100 patients and 100 healthy subjects were investigated in the study...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38495489/impact-of-linc00312-gene-polymorphism-coupled-with-habitual-risks-on-buccal-mucosa-cancer
#36
JOURNAL ARTICLE
Hui-Ting Hsu, Yen-Ting Lu, Yi-Tzu Chen, Ming-Tai Hsing, Chun-Wen Su, Shih-Chi Su, Chiao-Wen Lin, Shun-Fa Yang
Oral squamous cell carcinoma (OSCC) is a prevalent and lethal malignancy with a diverse etiology. LINC00312 is a long intergenic non-coding RNA that functions as a signal hub to regulate the progression and treatment of head and neck cancer. The aim of this study was to evaluate the effect of LINC00312 single nucleotide polymorphisms (SNPs) on the development of oral cancer. Two LINC00312 SNPs, namely rs12497104 and rs164966, were investigated among 469 male patients with cancer of buccal mucosa and 1194 gender- and age-matched controls...
2024: Journal of Cancer
https://read.qxmd.com/read/38494589/ikzf1-rs4132601-and-rs11978267-gene-polymorphisms-and-paediatric-systemic-lupus-erythematosus-relation-to-lupus-nephritis
#37
JOURNAL ARTICLE
Youssef M Mosaad, Ayman Hammad, Amany Shouma, Mohamed Darwish, Enas M Hammad, Rehab Ar Sallam, Noha T ELTantawi, Heba A Abdel-Azeem, Laila F Youssef, Noha T Abou El-Khier, Iman M Fawzy, Mona Alwasify
The demographic factors, the socioeconomic status and the ethnicity of populations are important players that determine the incidence, the prevalence and the spectrum of systemic lupus erythematosus (SLE) clinical presentations in different populations. Therefore, the purpose of the present research was to investigate the possible association between the Ikaros family zinc finger 1 gene (IKZF1) rs4132601 and rs11978267 single nucleotide polymorphisms (SNPs) and SLE susceptibility and clinical presentations including lupus nephritis (LN) among Egyptian paediatric patients...
March 17, 2024: International Journal of Immunogenetics
https://read.qxmd.com/read/38494379/does-overgrading-on-targeted-biopsy-of-magnetic-resonance-imaging-visible-lesions-in-prostate-cancer-lead-to-overtreatment
#38
JOURNAL ARTICLE
Michael Baboudjian, Romain Diamand, Alessandro Uleri, Jean-Baptiste Beauval, Alae Touzani, Jean-Baptiste Roche, Vito Lacetera, Thierry Roumeguère, Giuseppe Simone, Daniel Benamran, Alexandre Fourcade, Bastien Gondran-Tellier, Gaelle Fiard, Alexandre Peltier, Guillaume Ploussard
BACKGROUND AND OBJECTIVE: Targeted biopsy of the index prostate cancer (PCa) lesion on multiparametric magnetic resonance imaging (MRI) is effective in reducing the risk of overdiagnosis of indolent PCa. However, it remains to be determined whether MRI-targeted biopsy can lead to a stage shift via overgrading of the index lesion by focusing only on the highest-grade component, and to a subsequent risk of overtreatment. Our aim was to assess whether overgrading on MRI-targeted biopsy may lead to overtreatment, using radical prostatectomy (RP) specimens as the reference standard...
March 16, 2024: European Urology
https://read.qxmd.com/read/38494341/express-the-relationship-of-the-methylation-status-and-polymorphism-of-glucocorticoid-receptor-gene-nr3c1-with-attempted-suicide-or-non-suicidal-self-injury-patients-in-schizophrenia
#39
JOURNAL ARTICLE
Yasemin Oyaci, Yusuf Ezel Yildirim, Hasan Mervan Aytac, Sacide Pehlivan, Pinar Cetinay Aydin
We aim to investigate the methylation of NR3C1 gene promotor and NR3C1 BclI polymorphism in schizophrenia (SCZ) patients with attempted suicide or non-suicidal self-injury (NSSI). A sample of 112 patients with SCZ were included in the study. SCID-I was used to confirm the diagnosis according to DSM-IV-TR criteria. The patients were evaluated by data forms that had sociodemographic, suicidal behavior, and NSSI information. Methylation-specific PCR was used to identify the methylation of the NR3C1 gene. The analysis of the BclI polymorphism of the NR3C1 gene was evaluated by using the PCR-RFLP...
March 17, 2024: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/38493072/performance-of-a-region-of-interest-based-algorithm-in-diagnosing-international-society-of-urological-pathology-grade-group-%C3%A2-2-prostate-cancer-on-the-mri-first-database-cad-first-study
#40
JOURNAL ARTICLE
Thibaut Couchoux, Tristan Jaouen, Christelle Melodelima-Gonindard, Pierre Baseilhac, Arthur Branchu, Nicolas Arfi, Richard Aziza, Nicolas Barry Delongchamps, Franck Bladou, Flavie Bratan, Serge Brunelle, Pierre Colin, Jean-Michel Correas, François Cornud, Jean-Luc Descotes, Pascal Eschwege, Gaelle Fiard, Bénédicte Guillaume, Rémi Grange, Nicolas Grenier, Hervé Lang, Frédéric Lefèvre, Bernard Malavaud, Clément Marcelin, Paul C Moldovan, Nicolas Mottet, Pierre Mozer, Eric Potiron, Daniel Portalez, Philippe Puech, Raphaele Renard-Penna, Matthieu Roumiguié, Catherine Roy, Marc-Olivier Timsit, Thibault Tricard, Arnauld Villers, Jochen Walz, Sabine Debeer, Adeline Mansuy, Florence Mège-Lechevallier, Myriam Decaussin-Petrucci, Lionel Badet, Marc Colombel, Alain Ruffion, Sébastien Crouzet, Muriel Rabilloud, Rémi Souchon, Olivier Rouvière
BACKGROUND AND OBJECTIVE: Prostate multiparametric magnetic resonance imaging (MRI) shows high sensitivity for International Society of Urological Pathology grade group (GG) ≥2 cancers. Many artificial intelligence algorithms have shown promising results in diagnosing clinically significant prostate cancer on MRI. To assess a region-of-interest-based machine-learning algorithm aimed at characterising GG ≥2 prostate cancer on multiparametric MRI. METHODS: The lesions targeted at biopsy in the MRI-FIRST dataset were retrospectively delineated and assessed using a previously developed algorithm...
March 15, 2024: European Urology Oncology
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